FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB7820, 599 aa 1>>>pF1KB7820 599 - 599 aa - 599 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 9.2761+/-0.000897; mu= 1.0276+/- 0.054 mean_var=189.2893+/-38.095, 0's: 0 Z-trim(113.1): 25 B-trim: 3 in 1/52 Lambda= 0.093220 statistics sampled from 13793 (13814) to 13793 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.749), E-opt: 0.2 (0.424), width: 16 Scan time: 3.090 The best scores are: opt bits E(32554) CCDS14455.1 DACH2 gene_id:117154|Hs108|chrX ( 599) 3929 540.8 1.8e-153 CCDS55457.1 DACH2 gene_id:117154|Hs108|chrX ( 432) 2810 390.3 2.8e-108 CCDS48140.1 DACH2 gene_id:117154|Hs108|chrX ( 571) 2649 368.7 1.2e-101 CCDS41899.1 DACH1 gene_id:1602|Hs108|chr13 ( 706) 943 139.3 1.6e-32 >>CCDS14455.1 DACH2 gene_id:117154|Hs108|chrX (599 aa) initn: 3929 init1: 3929 opt: 3929 Z-score: 2868.6 bits: 540.8 E(32554): 1.8e-153 Smith-Waterman score: 3929; 100.0% identity (100.0% similar) in 599 aa overlap (1-599:1-599) 10 20 30 40 50 60 pF1KB7 MAVSASPVISATSSGAGVPGGLFRAEPLYSTPREPPRLTPNMINSFVVNNHSNSAGGGGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS14 MAVSASPVISATSSGAGVPGGLFRAEPLYSTPREPPRLTPNMINSFVVNNHSNSAGGGGR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 GNTNTNECRMVDMHGMKVASFLMDGQELICLPQVFDLFLKHLVGGLHTVYTKLKRLDISP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS14 GNTNTNECRMVDMHGMKVASFLMDGQELICLPQVFDLFLKHLVGGLHTVYTKLKRLDISP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 VVCTVEQVRILRGLGAIQPGVNRCKLITRKDFETLFTDCTNARRKRQMTRKQAVNSSRPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS14 VVCTVEQVRILRGLGAIQPGVNRCKLITRKDFETLFTDCTNARRKRQMTRKQAVNSSRPG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 RPPKRSLGVLQENARLLTHAVPGLLSPGLITPTGITAAAMAEAMKLQKMKLMAMNTLQGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS14 RPPKRSLGVLQENARLLTHAVPGLLSPGLITPTGITAAAMAEAMKLQKMKLMAMNTLQGN 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 GSQNGTESEPDDLNSNTGGSESSWDKDKMQSPFAAPGPQHGIAHAALAGQPGIGGAPTLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS14 GSQNGTESEPDDLNSNTGGSESSWDKDKMQSPFAAPGPQHGIAHAALAGQPGIGGAPTLN 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB7 PLQQNHLLTNRLDLPFMMMPHPLLPVSLPPASVAMAMNQMNHLNTIANMAAAAQIHSPLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS14 PLQQNHLLTNRLDLPFMMMPHPLLPVSLPPASVAMAMNQMNHLNTIANMAAAAQIHSPLS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB7 RAGTSVIKERIPESPSPAPSLEENHRPGSQTSSHTSSSVSSSPSQMDHHLERMEEVPVQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS14 RAGTSVIKERIPESPSPAPSLEENHRPGSQTSSHTSSSVSSSPSQMDHHLERMEEVPVQI 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB7 PIMKSPLDKIQLTPGQALPAGFPGPFIFADSLSSVETLLTNIQGLLKVALDNARIQEKQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS14 PIMKSPLDKIQLTPGQALPAGFPGPFIFADSLSSVETLLTNIQGLLKVALDNARIQEKQI 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB7 QQEKKELRLELYREREIRENLERQLAVELQSRTTMQKRLKKEKKTKRKLQEALEFESKRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS14 QQEKKELRLELYREREIRENLERQLAVELQSRTTMQKRLKKEKKTKRKLQEALEFESKRR 490 500 510 520 530 540 550 560 570 580 590 pF1KB7 EQVEQALKQATTSDSGLRMLKDTGIPDIEIENNGTPHDSAAMQGGNYYCLEMAQQLYSA ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS14 EQVEQALKQATTSDSGLRMLKDTGIPDIEIENNGTPHDSAAMQGGNYYCLEMAQQLYSA 550 560 570 580 590 >>CCDS55457.1 DACH2 gene_id:117154|Hs108|chrX (432 aa) initn: 2810 init1: 2810 opt: 2810 Z-score: 2057.4 bits: 390.3 E(32554): 2.8e-108 Smith-Waterman score: 2810; 100.0% identity (100.0% similar) in 432 aa overlap (168-599:1-432) 140 150 160 170 180 190 pF1KB7 QPGVNRCKLITRKDFETLFTDCTNARRKRQMTRKQAVNSSRPGRPPKRSLGVLQENARLL :::::::::::::::::::::::::::::: CCDS55 MTRKQAVNSSRPGRPPKRSLGVLQENARLL 10 20 30 200 210 220 230 240 250 pF1KB7 THAVPGLLSPGLITPTGITAAAMAEAMKLQKMKLMAMNTLQGNGSQNGTESEPDDLNSNT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 THAVPGLLSPGLITPTGITAAAMAEAMKLQKMKLMAMNTLQGNGSQNGTESEPDDLNSNT 40 50 60 70 80 90 260 270 280 290 300 310 pF1KB7 GGSESSWDKDKMQSPFAAPGPQHGIAHAALAGQPGIGGAPTLNPLQQNHLLTNRLDLPFM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 GGSESSWDKDKMQSPFAAPGPQHGIAHAALAGQPGIGGAPTLNPLQQNHLLTNRLDLPFM 100 110 120 130 140 150 320 330 340 350 360 370 pF1KB7 MMPHPLLPVSLPPASVAMAMNQMNHLNTIANMAAAAQIHSPLSRAGTSVIKERIPESPSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 MMPHPLLPVSLPPASVAMAMNQMNHLNTIANMAAAAQIHSPLSRAGTSVIKERIPESPSP 160 170 180 190 200 210 380 390 400 410 420 430 pF1KB7 APSLEENHRPGSQTSSHTSSSVSSSPSQMDHHLERMEEVPVQIPIMKSPLDKIQLTPGQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 APSLEENHRPGSQTSSHTSSSVSSSPSQMDHHLERMEEVPVQIPIMKSPLDKIQLTPGQA 220 230 240 250 260 270 440 450 460 470 480 490 pF1KB7 LPAGFPGPFIFADSLSSVETLLTNIQGLLKVALDNARIQEKQIQQEKKELRLELYREREI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 LPAGFPGPFIFADSLSSVETLLTNIQGLLKVALDNARIQEKQIQQEKKELRLELYREREI 280 290 300 310 320 330 500 510 520 530 540 550 pF1KB7 RENLERQLAVELQSRTTMQKRLKKEKKTKRKLQEALEFESKRREQVEQALKQATTSDSGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 RENLERQLAVELQSRTTMQKRLKKEKKTKRKLQEALEFESKRREQVEQALKQATTSDSGL 340 350 360 370 380 390 560 570 580 590 pF1KB7 RMLKDTGIPDIEIENNGTPHDSAAMQGGNYYCLEMAQQLYSA :::::::::::::::::::::::::::::::::::::::::: CCDS55 RMLKDTGIPDIEIENNGTPHDSAAMQGGNYYCLEMAQQLYSA 400 410 420 430 >>CCDS48140.1 DACH2 gene_id:117154|Hs108|chrX (571 aa) initn: 2649 init1: 2649 opt: 2649 Z-score: 1938.5 bits: 368.7 E(32554): 1.2e-101 Smith-Waterman score: 3698; 97.8% identity (97.8% similar) in 583 aa overlap (1-583:1-570) 10 20 30 40 50 60 pF1KB7 MAVSASPVISATSSGAGVPGGLFRAEPLYSTPREPPRLTPNMINSFVVNNHSNSAGGGGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS48 MAVSASPVISATSSGAGVPGGLFRAEPLYSTPREPPRLTPNMINSFVVNNHSNSAGGGGR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 GNTNTNECRMVDMHGMKVASFLMDGQELICLPQVFDLFLKHLVGGLHTVYTKLKRLDISP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS48 GNTNTNECRMVDMHGMKVASFLMDGQELICLPQVFDLFLKHLVGGLHTVYTKLKRLDISP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 VVCTVEQVRILRGLGAIQPGVNRCKLITRKDFETLFTDCTNARRKRQMTRKQAVNSSRPG :::::::::::::::::::::::::::::::::::::::::: ::::: CCDS48 VVCTVEQVRILRGLGAIQPGVNRCKLITRKDFETLFTDCTNA-------------SSRPG 130 140 150 160 190 200 210 220 230 240 pF1KB7 RPPKRSLGVLQENARLLTHAVPGLLSPGLITPTGITAAAMAEAMKLQKMKLMAMNTLQGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS48 RPPKRSLGVLQENARLLTHAVPGLLSPGLITPTGITAAAMAEAMKLQKMKLMAMNTLQGN 170 180 190 200 210 220 250 260 270 280 290 300 pF1KB7 GSQNGTESEPDDLNSNTGGSESSWDKDKMQSPFAAPGPQHGIAHAALAGQPGIGGAPTLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS48 GSQNGTESEPDDLNSNTGGSESSWDKDKMQSPFAAPGPQHGIAHAALAGQPGIGGAPTLN 230 240 250 260 270 280 310 320 330 340 350 360 pF1KB7 PLQQNHLLTNRLDLPFMMMPHPLLPVSLPPASVAMAMNQMNHLNTIANMAAAAQIHSPLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS48 PLQQNHLLTNRLDLPFMMMPHPLLPVSLPPASVAMAMNQMNHLNTIANMAAAAQIHSPLS 290 300 310 320 330 340 370 380 390 400 410 420 pF1KB7 RAGTSVIKERIPESPSPAPSLEENHRPGSQTSSHTSSSVSSSPSQMDHHLERMEEVPVQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS48 RAGTSVIKERIPESPSPAPSLEENHRPGSQTSSHTSSSVSSSPSQMDHHLERMEEVPVQI 350 360 370 380 390 400 430 440 450 460 470 480 pF1KB7 PIMKSPLDKIQLTPGQALPAGFPGPFIFADSLSSVETLLTNIQGLLKVALDNARIQEKQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS48 PIMKSPLDKIQLTPGQALPAGFPGPFIFADSLSSVETLLTNIQGLLKVALDNARIQEKQI 410 420 430 440 450 460 490 500 510 520 530 540 pF1KB7 QQEKKELRLELYREREIRENLERQLAVELQSRTTMQKRLKKEKKTKRKLQEALEFESKRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS48 QQEKKELRLELYREREIRENLERQLAVELQSRTTMQKRLKKEKKTKRKLQEALEFESKRR 470 480 490 500 510 520 550 560 570 580 590 pF1KB7 EQVEQALKQATTSDSGLRMLKDTGIPDIEIENNGTPHDSAAMQGGNYYCLEMAQQLYSA ::::::::::::::::::::::::::::::::::::::::::: CCDS48 EQVEQALKQATTSDSGLRMLKDTGIPDIEIENNGTPHDSAAMQA 530 540 550 560 570 >>CCDS41899.1 DACH1 gene_id:1602|Hs108|chr13 (706 aa) initn: 1787 init1: 577 opt: 943 Z-score: 697.1 bits: 139.3 E(32554): 1.6e-32 Smith-Waterman score: 1821; 51.2% identity (68.6% similar) in 643 aa overlap (4-588:148-699) 10 20 30 pF1KB7 MAVSASPVISATSSGAGVPGGLFRAEPLYSTPR :.: :..::... : . ..:.:::: CCDS41 GGGGISAGGGVASSTPINASTGSSSSSSSSSSSSSSSSSSSSSSSSCGPLPGKPVYSTPS 120 130 140 150 160 170 40 50 60 70 80 90 pF1KB7 EPPRLTPNMINSFVVNNHSNSAGGGGRGNTNTNECRMVDMHGMKVASFLMDGQELICLPQ : . ::. .:::.:::..: ::::: ..: ::::::: CCDS41 -PVENTPQ-----------------------NNECKMVDLRGAKVASFTVEGCELICLPQ 180 190 200 210 100 110 120 130 140 150 pF1KB7 VFDLFLKHLVGGLHTVYTKLKRLDISPVVCTVEQVRILRGLGAIQPGVNRCKLITRKDFE .::::::::::::::::::::::.:.::::.:::::::::::::::::::::::.::::: CCDS41 AFDLFLKHLVGGLHTVYTKLKRLEITPVVCNVEQVRILRGLGAIQPGVNRCKLISRKDFE 220 230 240 250 260 270 160 170 180 190 200 210 pF1KB7 TLFTDCTNARRKRQMTRKQAVNSSRPGRPPKRSLGVLQ-ENARLLTHAVPGLLSPGLITP ::..::::: ::::::::::. .: . ::.... :.::::.:::.: : CCDS41 TLYNDCTNA-------------SSRPGRPPKRTQSVTSPENSHIMPHSVPGLMSPGIIPP 280 290 300 310 320 220 230 240 250 260 pF1KB7 TGITAAA----------MAEAMKLQKMKLMAMNTLQGNGSQNGTESEPDDLNSNTGGSES ::.:::: .:::::..:.:: ::.. .....:.:..:: :.::..: CCDS41 TGLTAAAAAAAAATNAAIAEAMKVKKIKLEAMSNYHASNNQHGADSENGDMNSSVG---- 330 340 350 360 370 270 280 290 300 310 320 pF1KB7 SWDKDKMQSPFAAPGPQHGIAHAALAGQPGIGGAPTLNPLQQNHLLTNRLDLPFMMMPHP :.::::::::: CCDS41 -------------------------------------------------LELPFMMMPHP 380 330 340 350 360 370 380 pF1KB7 LLPVSLPPASVAMAMNQMNHLNTIANMAAAAQIHSPLSRAGTSVIKERIPESPSPAPSLE :.:::::::::.:::.:::::.::::::::::..:: ::. :::::::.:.::::::::: CCDS41 LIPVSLPPASVTMAMSQMNHLSTIANMAAAAQVQSPPSRVETSVIKERVPDSPSPAPSLE 390 400 410 420 430 440 390 400 pF1KB7 ENHRPGSQTSSHTSSSVSSSPSQ------------------------------------- :..::::. ::: ::::::::.. CCDS41 EGRRPGSHPSSHRSSSVSSSPARTESSSDRIPVHQNGLSMNQMLMGLSPNVLPGPKEGDL 450 460 470 480 490 500 410 420 430 440 450 pF1KB7 ----MDHHLERM----EEVPVQIPIMKSPLDKIQLTP-GQALPAGFPGPFIFADSLSSVE : :. .:: .:.:.. : .. :::..:: :: :: :::.::.: :.:::.: CCDS41 AGHDMGHESKRMHIEKDETPLSTPTARDSLDKLSLTGHGQPLPPGFPSPFLFPDGLSSIE 510 520 530 540 550 560 460 470 480 490 500 510 pF1KB7 TLLTNIQGLLKVALDNARIQEKQIQQEKKELRLELYREREIRENLERQLAVELQSRTTMQ :::::::::::::.:::: ::::.: :: ::.... ::::.::.::.:::.: ..:. .: CCDS41 TLLTNIQGLLKVAIDNARAQEKQVQLEKTELKMDFLRERELRETLEKQLAMEQKNRAIVQ 570 580 590 600 610 620 520 530 540 550 560 570 pF1KB7 KRLKKEKKTKRKLQEALEFESKRREQVEQALKQATTSDSGLRMLKDTGIPDIEIENNGTP ::::::::.:::::::::::.:::::.::.::::...:: ::.:.:. :.:: . .: CCDS41 KRLKKEKKAKRKLQEALEFETKRREQAEQTLKQAASTDS-LRVLNDSLTPEIEADRSGGR 630 640 650 660 670 680 580 590 pF1KB7 HDSA-AMQGGNYYCLEMAQQLYSA :. ..: : : CCDS41 TDAERTIQDGRLYLKTTVMY 690 700 599 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 09:50:43 2016 done: Sat Nov 5 09:50:44 2016 Total Scan time: 3.090 Total Display time: 0.020 Function used was FASTA [36.3.4 Apr, 2011]