FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB7821, 536 aa 1>>>pF1KB7821 536 - 536 aa - 536 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.8195+/-0.0011; mu= 6.5692+/- 0.066 mean_var=125.1048+/-24.966, 0's: 0 Z-trim(106.6): 34 B-trim: 63 in 1/51 Lambda= 0.114667 statistics sampled from 9049 (9072) to 9049 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.635), E-opt: 0.2 (0.279), width: 16 Scan time: 2.830 The best scores are: opt bits E(32554) CCDS5124.1 HSF2 gene_id:3298|Hs108|chr6 ( 536) 3453 582.8 3.3e-166 CCDS47470.1 HSF2 gene_id:3298|Hs108|chr6 ( 518) 2554 434.1 1.9e-121 CCDS6419.1 HSF1 gene_id:3297|Hs108|chr8 ( 529) 837 150.1 6.2e-36 CCDS42175.1 HSF4 gene_id:3299|Hs108|chr16 ( 492) 670 122.4 1.2e-27 CCDS45510.1 HSF4 gene_id:3299|Hs108|chr16 ( 462) 649 118.9 1.3e-26 >>CCDS5124.1 HSF2 gene_id:3298|Hs108|chr6 (536 aa) initn: 3453 init1: 3453 opt: 3453 Z-score: 3097.3 bits: 582.8 E(32554): 3.3e-166 Smith-Waterman score: 3453; 100.0% identity (100.0% similar) in 536 aa overlap (1-536:1-536) 10 20 30 40 50 60 pF1KB7 MKQSSNVPAFLSKLWTLVEETHTNEFITWSQNGQSFLVLDEQRFAKEILPKYFKHNNMAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS51 MKQSSNVPAFLSKLWTLVEETHTNEFITWSQNGQSFLVLDEQRFAKEILPKYFKHNNMAS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 FVRQLNMYGFRKVVHIDSGIVKQERDGPVEFQHPYFKQGQDDLLENIKRKVSSSKPEENK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS51 FVRQLNMYGFRKVVHIDSGIVKQERDGPVEFQHPYFKQGQDDLLENIKRKVSSSKPEENK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 IRQEDLTKIISSAQKVQIKQETIESRLSELKSENESLWKEVSELRAKHAQQQQVIRKIVQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS51 IRQEDLTKIISSAQKVQIKQETIESRLSELKSENESLWKEVSELRAKHAQQQQVIRKIVQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 FIVTLVQNNQLVSLKRKRPLLLNTNGAQKKNLFQHIVKEPTDNHHHKVPHSRTEGLKPRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS51 FIVTLVQNNQLVSLKRKRPLLLNTNGAQKKNLFQHIVKEPTDNHHHKVPHSRTEGLKPRE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 RISDDIIIYDVTDDNADEENIPVIPETNEDVISDPSNCSQYPDIVIVEDDNEDEYAPVIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS51 RISDDIIIYDVTDDNADEENIPVIPETNEDVISDPSNCSQYPDIVIVEDDNEDEYAPVIQ 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB7 SGEQNEPARESLSSGSDGSSPLMSSAVQLNGSSSLTSEDPVTMMDSILNDNINLLGKVEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS51 SGEQNEPARESLSSGSDGSSPLMSSAVQLNGSSSLTSEDPVTMMDSILNDNINLLGKVEL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB7 LDYLDSIDCSLEDFQAMLSGRQFSIDPDLLVDLFTSSVQMNPTDYINNTKSENKGLETTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS51 LDYLDSIDCSLEDFQAMLSGRQFSIDPDLLVDLFTSSVQMNPTDYINNTKSENKGLETTK 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB7 NNVVQPVSEEGRKSKSKPDKQLIQYTAFPLLAFLDGNPASSVEQASTTASSEVLSSVDKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS51 NNVVQPVSEEGRKSKSKPDKQLIQYTAFPLLAFLDGNPASSVEQASTTASSEVLSSVDKP 430 440 450 460 470 480 490 500 510 520 530 pF1KB7 IEVDELLDSSLDPEPTQSKLVRLEPLTEAEASEATLFYLCELAPAPLDSDMPLLDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS51 IEVDELLDSSLDPEPTQSKLVRLEPLTEAEASEATLFYLCELAPAPLDSDMPLLDS 490 500 510 520 530 >>CCDS47470.1 HSF2 gene_id:3298|Hs108|chr6 (518 aa) initn: 3324 init1: 2548 opt: 2554 Z-score: 2293.8 bits: 434.1 E(32554): 1.9e-121 Smith-Waterman score: 3292; 96.6% identity (96.6% similar) in 536 aa overlap (1-536:1-518) 10 20 30 40 50 60 pF1KB7 MKQSSNVPAFLSKLWTLVEETHTNEFITWSQNGQSFLVLDEQRFAKEILPKYFKHNNMAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 MKQSSNVPAFLSKLWTLVEETHTNEFITWSQNGQSFLVLDEQRFAKEILPKYFKHNNMAS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 FVRQLNMYGFRKVVHIDSGIVKQERDGPVEFQHPYFKQGQDDLLENIKRKVSSSKPEENK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 FVRQLNMYGFRKVVHIDSGIVKQERDGPVEFQHPYFKQGQDDLLENIKRKVSSSKPEENK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 IRQEDLTKIISSAQKVQIKQETIESRLSELKSENESLWKEVSELRAKHAQQQQVIRKIVQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 IRQEDLTKIISSAQKVQIKQETIESRLSELKSENESLWKEVSELRAKHAQQQQVIRKIVQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 FIVTLVQNNQLVSLKRKRPLLLNTNGAQKKNLFQHIVKEPTDNHHHKVPHSRTEGLKPRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 FIVTLVQNNQLVSLKRKRPLLLNTNGAQKKNLFQHIVKEPTDNHHHKVPHSRTEGLKPRE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 RISDDIIIYDVTDDNADEENIPVIPETNEDVISDPSNCSQYPDIVIVEDDNEDEYAPVIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 RISDDIIIYDVTDDNADEENIPVIPETNEDVISDPSNCSQYPDIVIVEDDNEDEYAPVIQ 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB7 SGEQNEPARESLSSGSDGSSPLMSSAVQLNGSSSLTSEDPVTMMDSILNDNINLLGKVEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 SGEQNEPARESLSSGSDGSSPLMSSAVQLNGSSSLTSEDPVTMMDSILNDNINLLGKVEL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB7 LDYLDSIDCSLEDFQAMLSGRQFSIDPDLLVDLFTSSVQMNPTDYINNTKSENKGLETTK :::::::::::::::::::::::::::::::: :::::::::: CCDS47 LDYLDSIDCSLEDFQAMLSGRQFSIDPDLLVD------------------SENKGLETTK 370 380 390 400 430 440 450 460 470 480 pF1KB7 NNVVQPVSEEGRKSKSKPDKQLIQYTAFPLLAFLDGNPASSVEQASTTASSEVLSSVDKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 NNVVQPVSEEGRKSKSKPDKQLIQYTAFPLLAFLDGNPASSVEQASTTASSEVLSSVDKP 410 420 430 440 450 460 490 500 510 520 530 pF1KB7 IEVDELLDSSLDPEPTQSKLVRLEPLTEAEASEATLFYLCELAPAPLDSDMPLLDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 IEVDELLDSSLDPEPTQSKLVRLEPLTEAEASEATLFYLCELAPAPLDSDMPLLDS 470 480 490 500 510 >>CCDS6419.1 HSF1 gene_id:3297|Hs108|chr8 (529 aa) initn: 706 init1: 493 opt: 837 Z-score: 758.6 bits: 150.1 E(32554): 6.2e-36 Smith-Waterman score: 1009; 39.7% identity (65.7% similar) in 478 aa overlap (5-457:13-480) 10 20 30 40 50 pF1KB7 MKQSSNVPAFLSKLWTLVEETHTNEFITWSQNGQSFLVLDEQRFAKEILPKY :::::::.:::::: . :. .: :: .:.:: :.:. .::::.:::: CCDS64 MDLPVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLPKY 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB7 FKHNNMASFVRQLNMYGFRKVVHIDSG-IVKQERDGPVEFQHPYFKQGQDDLLENIKRKV ::::::::::::::::::::::::..: .:: ::: .::::: : .::..::::::::: CCDS64 FKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDD-TEFQHPCFLRGQEQLLENIKRKV 70 80 90 100 110 120 130 140 150 160 pF1KB7 SSS---KPEENKIRQEDLTKIISSAQKVQIKQETIESRLSELKSENESLWKEVSELRAKH .: : :. ::::...::.....: .. ::: ..:.: .: :::.::.::. :: :: CCDS64 TSVSTLKSEDIKIRQDSVTKLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKH 120 130 140 150 160 170 170 180 190 200 210 220 pF1KB7 AQQQQVIRKIVQFIVTLVQNNQLVSLKRKRPLLLNTNGAQK---KNLFQHIVKEPTDNHH ::::.:. :..::...:::.:.....::: ::.:: .:. . : : ... . CCDS64 AQQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLNDSGSAHSMPKYSRQFSLEHVHGSGP 180 190 200 210 220 230 230 240 250 260 270 280 pF1KB7 HKVP---HSRTEGLKPRERISDDIIIYDVTDDNADEENIPVIPETNEDVISDPSNCSQYP ...: .: . : :. :: :.: : :. : .. : :. : CCDS64 YSAPSPAYSSSSLYAPDAVASSGPIISDIT------ELAPASPMASPGGSIDERPLSSSP 240 250 260 270 280 290 290 300 310 320 330 pF1KB7 DIVIVEDDNEDEYAPVIQSGEQNEPAR-ESLSSGS---DG----SSPLMSSAVQLNGSSS . . :. .: .. . ..:. ..: : . :. : : .:.. :. . . CCDS64 LVRVKEEPPSPPQSPRVEEASPGRPSSVDTLLSPTALIDSILRESEPAPASVTALTDARG 300 310 320 330 340 350 340 350 360 370 380 pF1KB7 LT-------SEDPVTMMDSILNDNINLLGKVELLDYLDSIDCSLEDFQAMLSGRQFSIDP : : :.. .. : .. : : :: :.::..: .:...:.:::.. ::.: CCDS64 HTDTEGRPPSPPPTSTPEKCL--SVACLDKNELSDHLDAMDSNLDNLQTMLSSHGFSVDT 360 370 380 390 400 410 390 400 410 420 430 440 pF1KB7 DLLVDLFTSSVQMNPTDYINNTKSENKGLETTKNNVVQPVSEEGRKSKSKPDKQLIQYTA . :.:::. :: . : . . : ... . : :...:. :::..::: CCDS64 SALLDLFSPSVTV-PDMSLPDLDSSLASIQELLSPQEPPRPPEAENSSPDSGKQLVHYTA 420 430 440 450 460 470 450 460 470 480 490 500 pF1KB7 FPLLAFLDGNPASSVEQASTTASSEVLSSVDKPIEVDELLDSSLDPEPTQSKLVRLEPLT ::. . :. CCDS64 QPLFLLDPGSVDTGSNDLPVLFELGEGSYFSEGDGFAEDPTISLLTGSEPPKAKDPTVS 480 490 500 510 520 >>CCDS42175.1 HSF4 gene_id:3299|Hs108|chr16 (492 aa) initn: 674 init1: 625 opt: 670 Z-score: 609.8 bits: 122.4 E(32554): 1.2e-27 Smith-Waterman score: 670; 34.4% identity (63.1% similar) in 404 aa overlap (5-399:15-403) 10 20 30 40 50 pF1KB7 MKQSSNVPAFLSKLWTLVEETHTNEFITWSQNGQSFLVLDEQRFAKEILP : :::::.:::.:: . :...: :: .: :::: :..:::::.:: CCDS42 MQEAPAALPTEPGPSPVPAFLGKLWALVGDPGTDHLIRWSPSGTSFLVSDQSRFAKEVLP 10 20 30 40 50 60 60 70 80 90 100 pF1KB7 KYFKHNNMASFVRQLNMYGFRKVVHIDSG-IVKQERDGPVEFQHPYFKQGQDDLLENIKR .::::.:::::::::::::::::: :..: ... ::: :::::: : .:...::: ..: CCDS42 QYFKHSNMASFVRQLNMYGFRKVVSIEQGGLLRPERDH-VEFQHPSFVRGREQLLERVRR 70 80 90 100 110 110 120 130 140 150 160 pF1KB7 KVSSSKPEENKIRQEDLTKIISSAQKVQIKQETIESRLSELKSENESLWKEVSELRAKHA :: . . .... : ::: .... .: .. ::. :.:: ::...:: ::.:: :: .:. CCDS42 KVPALRGDDGRWRPEDLGRLLGEVQALRGVQESTEARLRELRQQNEILWREVVTLRQSHG 120 130 140 150 160 170 170 180 190 200 210 220 pF1KB7 QQQQVIRKIVQFIVTLVQNNQL-VSLKRKRPLLLNTNGAQKKNLFQHIVKEP----TDNH ::..:: :..: . .: . .. ::: :.:. ... . : : . CCDS42 QQHRVIGKLIQCLFGPLQAGPSNAGGKRKLSLMLDEGSSCPTPAKFNTCPLPGALLQDPY 180 190 200 210 220 230 230 240 250 260 270 280 pF1KB7 HHKVPHSRTE-GLKPRERISDDIIIYDVTDDNADEENIPVIPETNEDVISDPSNCSQYPD . : .:. ::.:.. . :: :. .:. . :: .. .: :. . CCDS42 FIQSPLPETNLGLSPHR--ARGPIISDIPEDSPS-------PEGTR--LSPSSDGRREKG 240 250 260 270 280 290 300 310 320 330 340 pF1KB7 IVIVEDDNEDEYAPVIQSGEQNEPARESLSSGSDGSSPLMSSAVQLNGSSSLTSEDPVTM ....... . . ..: : . .. . :. . :.:..:.. : : . CCDS42 LALLKEEPASPGGDG-EAGLALAPNECDFCVTAPPPLPVAVVQAILEGKGSFSPEGPRNA 290 300 310 320 330 340 350 360 370 380 390 400 pF1KB7 MDSILNDNINLLGKVELLDYLDSIDCSLEDF--QAMLSGRQFSIDPDLLVDLFTSSVQMN .. .: .. . : :.: : : :.. .:. : :..: .:.. :.: CCDS42 QQPEPGDPREIPDRGPL--GLESGDRSPESLLPPMLLQPPQESVEPAGPLDVLGPSLQGR 350 360 370 380 390 400 410 420 430 440 450 460 pF1KB7 PTDYINNTKSENKGLETTKNNVVQPVSEEGRKSKSKPDKQLIQYTAFPLLAFLDGNPASS CCDS42 EWTLMDLDMELSLMQPLVPERGEPELAVKGLNSPSPGKDPTLGAPLLLDVQAALGGPALG 410 420 430 440 450 460 >>CCDS45510.1 HSF4 gene_id:3299|Hs108|chr16 (462 aa) initn: 649 init1: 625 opt: 649 Z-score: 591.4 bits: 118.9 E(32554): 1.3e-26 Smith-Waterman score: 649; 50.7% identity (78.1% similar) in 201 aa overlap (5-203:15-214) 10 20 30 40 50 pF1KB7 MKQSSNVPAFLSKLWTLVEETHTNEFITWSQNGQSFLVLDEQRFAKEILP : :::::.:::.:: . :...: :: .: :::: :..:::::.:: CCDS45 MQEAPAALPTEPGPSPVPAFLGKLWALVGDPGTDHLIRWSPSGTSFLVSDQSRFAKEVLP 10 20 30 40 50 60 60 70 80 90 100 pF1KB7 KYFKHNNMASFVRQLNMYGFRKVVHIDSG-IVKQERDGPVEFQHPYFKQGQDDLLENIKR .::::.:::::::::::::::::: :..: ... ::: :::::: : .:...::: ..: CCDS45 QYFKHSNMASFVRQLNMYGFRKVVSIEQGGLLRPERDH-VEFQHPSFVRGREQLLERVRR 70 80 90 100 110 110 120 130 140 150 160 pF1KB7 KVSSSKPEENKIRQEDLTKIISSAQKVQIKQETIESRLSELKSENESLWKEVSELRAKHA :: . . .... : ::: .... .: .. ::. :.:: ::...:: ::.:: :: .:. CCDS45 KVPALRGDDGRWRPEDLGRLLGEVQALRGVQESTEARLRELRQQNEILWREVVTLRQSHG 120 130 140 150 160 170 170 180 190 200 210 220 pF1KB7 QQQQVIRKIVQFIVTLVQNNQL-VSLKRKRPLLLNTNGAQKKNLFQHIVKEPTDNHHHKV ::..:: :..: . .: . .. ::: :.:. CCDS45 QQHRVIGKLIQCLFGPLQAGPSNAGGKRKLSLMLDEGSSCPTPAKFNTCPLPGALLQDPY 180 190 200 210 220 230 230 240 250 260 270 280 pF1KB7 PHSRTEGLKPRERISDDIIIYDVTDDNADEENIPVIPETNEDVISDPSNCSQYPDIVIVE CCDS45 FIQSPSTYSLSQRQIWALALTGPGAPSSLTSQKTLHPLRGPGFLPPVMAGAPPPLPVAVV 240 250 260 270 280 290 536 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 22:26:24 2016 done: Fri Nov 4 22:26:25 2016 Total Scan time: 2.830 Total Display time: 0.020 Function used was FASTA [36.3.4 Apr, 2011]