FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB7841, 504 aa 1>>>pF1KB7841 504 - 504 aa - 504 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.3728+/-0.000392; mu= 9.2007+/- 0.025 mean_var=128.0934+/-25.715, 0's: 0 Z-trim(115.8): 28 B-trim: 293 in 1/57 Lambda= 0.113321 statistics sampled from 26479 (26507) to 26479 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.674), E-opt: 0.2 (0.311), width: 16 Scan time: 9.040 The best scores are: opt bits E(85289) NP_001121632 (OMIM: 609784) upstream-binding prote ( 504) 3376 563.4 5.4e-160 NP_005644 (OMIM: 189889) alpha-globin transcriptio ( 502) 2517 423.0 1e-117 NP_001166923 (OMIM: 189889) alpha-globin transcrip ( 501) 2500 420.2 7e-117 NP_001121633 (OMIM: 609784) upstream-binding prote ( 540) 1867 316.7 1.1e-85 NP_055332 (OMIM: 609784) upstream-binding protein ( 540) 1867 316.7 1.1e-85 XP_016859391 (OMIM: 609785) PREDICTED: transcripti ( 406) 1863 316.0 1.3e-85 NP_055368 (OMIM: 609785) transcription factor CP2- ( 479) 1854 314.6 4.2e-85 XP_016859393 (OMIM: 609785) PREDICTED: transcripti ( 273) 1399 240.0 6.4e-63 XP_016859394 (OMIM: 609785) PREDICTED: transcripti ( 273) 1391 238.7 1.6e-62 NP_001166924 (OMIM: 189889) alpha-globin transcrip ( 450) 1099 191.1 5.7e-48 XP_016859392 (OMIM: 609785) PREDICTED: transcripti ( 274) 790 140.5 6.1e-33 XP_016859390 (OMIM: 609786) PREDICTED: grainyhead- ( 467) 385 74.4 8.1e-13 XP_005246216 (OMIM: 609786) PREDICTED: grainyhead- ( 429) 383 74.0 9.5e-13 NP_937825 (OMIM: 609786) grainyhead-like protein 1 ( 618) 385 74.5 1e-12 XP_016859389 (OMIM: 609786) PREDICTED: grainyhead- ( 479) 360 70.3 1.4e-11 XP_006711947 (OMIM: 609786) PREDICTED: grainyhead- ( 441) 358 70.0 1.6e-11 XP_011508645 (OMIM: 609786) PREDICTED: grainyhead- ( 583) 360 70.4 1.7e-11 XP_006711945 (OMIM: 609786) PREDICTED: grainyhead- ( 630) 360 70.4 1.8e-11 XP_011540172 (OMIM: 606713,608317) PREDICTED: grai ( 509) 351 68.9 4.1e-11 NP_001181939 (OMIM: 606713,608317) grainyhead-like ( 556) 351 68.9 4.4e-11 XP_011540171 (OMIM: 606713,608317) PREDICTED: grai ( 556) 351 68.9 4.4e-11 NP_937816 (OMIM: 606713,608317) grainyhead-like pr ( 602) 351 68.9 4.7e-11 NP_067003 (OMIM: 606713,608317) grainyhead-like pr ( 607) 351 68.9 4.7e-11 NP_937817 (OMIM: 606713,608317) grainyhead-like pr ( 626) 351 68.9 4.9e-11 XP_011515609 (OMIM: 608576,608641,616029) PREDICTE ( 591) 343 67.6 1.1e-10 NP_001317522 (OMIM: 608576,608641,616029) grainyhe ( 609) 343 67.6 1.2e-10 XP_011515608 (OMIM: 608576,608641,616029) PREDICTE ( 609) 343 67.6 1.2e-10 NP_079191 (OMIM: 608576,608641,616029) grainyhead- ( 625) 343 67.6 1.2e-10 >>NP_001121632 (OMIM: 609784) upstream-binding protein 1 (504 aa) initn: 3376 init1: 3376 opt: 3376 Z-score: 2993.3 bits: 563.4 E(85289): 5.4e-160 Smith-Waterman score: 3376; 100.0% identity (100.0% similar) in 504 aa overlap (1-504:1-504) 10 20 30 40 50 60 pF1KB7 MAWVLKMDEVIESGLVHDFDASLSGIGQELGAGAYSMSDVLALPIFKQEDSSLPLDGETE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAWVLKMDEVIESGLVHDFDASLSGIGQELGAGAYSMSDVLALPIFKQEDSSLPLDGETE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 HPPFQYVMCAATSPAVKLHDETLTYLNQGQSYEIRMLDNRKMGDMPEINGKLVKSIIRVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HPPFQYVMCAATSPAVKLHDETLTYLNQGQSYEIRMLDNRKMGDMPEINGKLVKSIIRVV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 FHDRRLQYTEHQQLEGWKWNRPGDRLLDLDIPMSVGIIDTRTNPSQLNAVEFLWDPAKRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FHDRRLQYTEHQQLEGWKWNRPGDRLLDLDIPMSVGIIDTRTNPSQLNAVEFLWDPAKRT 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 SAFIQVHCISTEFTPRKHGGEKGVPFRIQVDTFKQNENGEYTDHLHSASCQIKVFKPKGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SAFIQVHCISTEFTPRKHGGEKGVPFRIQVDTFKQNENGEYTDHLHSASCQIKVFKPKGA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 DRKQKTDREKMEKRTAHEKEKYQPSYDTTILTECSPWPDAPTAYVNNSPSPAPTFTSPQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DRKQKTDREKMEKRTAHEKEKYQPSYDTTILTECSPWPDAPTAYVNNSPSPAPTFTSPQQ 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB7 STCSVPDSNSSSPNHQGDGASQTSGEQIQPSATIQETQQWLLKNRFSSYTRLFSNFSGAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 STCSVPDSNSSSPNHQGDGASQTSGEQIQPSATIQETQQWLLKNRFSSYTRLFSNFSGAD 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB7 LLKLTKEDLVQICGAADGIRLYNSLKSRSVRPRLTIYVCREQPSSTVLQGQQQAASSASE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLKLTKEDLVQICGAADGIRLYNSLKSRSVRPRLTIYVCREQPSSTVLQGQQQAASSASE 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB7 NGSGAPYVYHAIYLEEMIASEVARKLALVFNIPLHQINQVYRQGPTGIHILVSDQMVQNF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NGSGAPYVYHAIYLEEMIASEVARKLALVFNIPLHQINQVYRQGPTGIHILVSDQMVQNF 430 440 450 460 470 480 490 500 pF1KB7 QDESCFLFSTVKAESSDGIHIILK :::::::::::::::::::::::: NP_001 QDESCFLFSTVKAESSDGIHIILK 490 500 >>NP_005644 (OMIM: 189889) alpha-globin transcription fa (502 aa) initn: 2124 init1: 1693 opt: 2517 Z-score: 2234.4 bits: 423.0 E(85289): 1e-117 Smith-Waterman score: 2517; 73.3% identity (90.4% similar) in 509 aa overlap (1-504:1-502) 10 20 30 40 50 pF1KB7 MAWVLKM---DEVIESGLVHDFDASLSGIGQELGAGAYSMSDVLALPIFKQEDSSLPLDG :::.::. :::::::::.::::::::::::::::::::::::::::::::.:::: :. NP_005 MAWALKLPLADEVIESGLVQDFDASLSGIGQELGAGAYSMSDVLALPIFKQEESSLPPDN 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB7 ETEHPPFQYVMCAATSPAVKLHDETLTYLNQGQSYEIRMLDNRKMGDMPEINGKLVKSII :.. :::::.:::::::::::::::::::::::::::::::::.:..:::::::::::. NP_005 ENKILPFQYVLCAATSPAVKLHDETLTYLNQGQSYEIRMLDNRKLGELPEINGKLVKSIF 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB7 RVVFHDRRLQYTEHQQLEGWKWNRPGDRLLDLDIPMSVGIIDTRTNPSQLNAVEFLWDPA ::::::::::::::::::::.:::::::.::.:::::::::: :.::.:::.:::::::: NP_005 RVVFHDRRLQYTEHQQLEGWRWNRPGDRILDIDIPMSVGIIDPRANPTQLNTVEFLWDPA 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB7 KRTSAFIQVHCISTEFTPRKHGGEKGVPFRIQVDTFKQNENGEYTDHLHSASCQIKVFKP ::::.:::::::::::: ::::::::::::.:.::::.:::::::.:::::::::::::: NP_005 KRTSVFIQVHCISTEFTMRKHGGEKGVPFRVQIDTFKENENGEYTEHLHSASCQIKVFKP 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB7 KGADRKQKTDREKMEKRTAHEKEKYQPSYDTTILTECSPWPDAPTAYVNNSPSPAPTFTS :::::::::::::::::: ::::::::::.:::::::::::. .::::::::. :.: NP_005 KGADRKQKTDREKMEKRTPHEKEKYQPSYETTILTECSPWPE--ITYVNNSPSPG--FNS 250 260 270 280 290 300 310 320 330 340 350 pF1KB7 PQQSTCSVPDSNSSSPNHQGDGASQTSGEQIQPSATIQETQQWLLKNRFSSYTRLFSNFS ..:. :. ..:.: :::: . .. ... :..: ::.:::: .::::..::::.::: NP_005 -SHSSFSLGEGNGS-PNHQPEPPPPVT-DNLLPTTTPQEAQQWLHRNRFSTFTRLFTNFS 300 310 320 330 340 350 360 370 380 390 400 410 pF1KB7 GADLLKLTKEDLVQICGAADGIRLYNSLKSRSVRPRLTIYVCREQPSSTVLQGQQQAASS ::::::::..:..:::: ::::::.:.::.: ::::::::::.:. . : ::: .. NP_005 GADLLKLTRDDVIQICGPADGIRLFNALKGRMVRPRLTIYVCQESLQLREQQQQQQQQQQ 360 370 380 390 400 410 420 430 440 450 460 470 pF1KB7 ASENG--SGAPYVYHAIYLEEMIASEVARKLALVFNIPLHQINQVYRQGPTGIHILVSDQ :.: .:. .:::::::::. : :...:.: .:.: ::.:.:.:::::::.:.::. NP_005 KHEDGDSNGTFFVYHAIYLEELTAVELTEKIAQLFSISPCQISQIYKQGPTGIHVLISDE 420 430 440 450 460 470 480 490 500 pF1KB7 MVQNFQDESCFLFSTVKAESSDGIHIILK :.::::.:.::...:.:::..:. ::::: NP_005 MIQNFQEEACFILDTMKAETNDSYHIILK 480 490 500 >>NP_001166923 (OMIM: 189889) alpha-globin transcription (501 aa) initn: 2457 init1: 1693 opt: 2500 Z-score: 2219.4 bits: 420.2 E(85289): 7e-117 Smith-Waterman score: 2500; 73.1% identity (90.2% similar) in 509 aa overlap (1-504:1-501) 10 20 30 40 50 pF1KB7 MAWVLKM---DEVIESGLVHDFDASLSGIGQELGAGAYSMSDVLALPIFKQEDSSLPLDG :::.::. :::::::::.::::::::::::::::::::::::::::::::.:::: :. NP_001 MAWALKLPLADEVIESGLVQDFDASLSGIGQELGAGAYSMSDVLALPIFKQEESSLPPDN 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB7 ETEHPPFQYVMCAATSPAVKLHDETLTYLNQGQSYEIRMLDNRKMGDMPEINGKLVKSII :.. :::::.:::::::::::::::::::::::::::::::::.:..:::::::::::. NP_001 ENKILPFQYVLCAATSPAVKLHDETLTYLNQGQSYEIRMLDNRKLGELPEINGKLVKSIF 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB7 RVVFHDRRLQYTEHQQLEGWKWNRPGDRLLDLDIPMSVGIIDTRTNPSQLNAVEFLWDPA ::::::::::::::::::::.:::::::.::.:::::::::: :.::.:::.:::::::: NP_001 RVVFHDRRLQYTEHQQLEGWRWNRPGDRILDIDIPMSVGIIDPRANPTQLNTVEFLWDPA 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB7 KRTSAFIQVHCISTEFTPRKHGGEKGVPFRIQVDTFKQNENGEYTDHLHSASCQIKVFKP ::::.:::::::::::: ::::::::::::.:.::::.:::::::.:::::::::::::: NP_001 KRTSVFIQVHCISTEFTMRKHGGEKGVPFRVQIDTFKENENGEYTEHLHSASCQIKVFKP 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB7 KGADRKQKTDREKMEKRTAHEKEKYQPSYDTTILTECSPWPDAPTAYVNNSPSPAPTFTS :::::::::::::::::: ::::::::::.:::::::::::. .::::::::. :.: NP_001 KGADRKQKTDREKMEKRTPHEKEKYQPSYETTILTECSPWPE--ITYVNNSPSPG--FNS 250 260 270 280 290 300 310 320 330 340 350 pF1KB7 PQQSTCSVPDSNSSSPNHQGDGASQTSGEQIQPSATIQETQQWLLKNRFSSYTRLFSNFS ..:. :. ..:.: :::: . .. ... :..: ::.:::: .::::..::::.::: NP_001 -SHSSFSLGEGNGS-PNHQPEPPPPVT-DNLLPTTTPQEAQQWLHRNRFSTFTRLFTNFS 300 310 320 330 340 350 360 370 380 390 400 410 pF1KB7 GADLLKLTKEDLVQICGAADGIRLYNSLKSRSVRPRLTIYVCREQPSSTVLQGQQQAASS ::::::::..:..:::: ::::::.:.::.: ::::::::::.:. . : ::: .. NP_001 GADLLKLTRDDVIQICGPADGIRLFNALKGRMVRPRLTIYVCQESLQLREQQQQQQQQQQ 360 370 380 390 400 410 420 430 440 450 460 470 pF1KB7 ASENG--SGAPYVYHAIYLEEMIASEVARKLALVFNIPLHQINQVYRQGPTGIHILVSDQ :.: .:. .:::::::::. : :...:.: .:.: ::.:.:.:::::::.:.::. NP_001 KHEDGDSNGTFFVYHAIYLEELTAVELTEKIAQLFSISPCQISQIYKQGPTGIHVLISDE 420 430 440 450 460 470 480 490 500 pF1KB7 MVQNFQDESCFLFSTVKAESSDGIHIILK :.::::.:.::...:.: :..:. ::::: NP_001 MIQNFQEEACFILDTMK-ETNDSYHIILK 480 490 500 >>NP_001121633 (OMIM: 609784) upstream-binding protein 1 (540 aa) initn: 3362 init1: 1847 opt: 1867 Z-score: 1659.6 bits: 316.7 E(85289): 1.1e-85 Smith-Waterman score: 3273; 93.3% identity (93.3% similar) in 536 aa overlap (1-500:1-536) 10 20 30 40 50 60 pF1KB7 MAWVLKMDEVIESGLVHDFDASLSGIGQELGAGAYSMSDVLALPIFKQEDSSLPLDGETE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAWVLKMDEVIESGLVHDFDASLSGIGQELGAGAYSMSDVLALPIFKQEDSSLPLDGETE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 HPPFQYVMCAATSPAVKLHDETLTYLNQGQSYEIRMLDNRKMGDMPEINGKLVKSIIRVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HPPFQYVMCAATSPAVKLHDETLTYLNQGQSYEIRMLDNRKMGDMPEINGKLVKSIIRVV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 FHDRRLQYTEHQQLEGWKWNRPGDRLLDLDIPMSVGIIDTRTNPSQLNAVEFLWDPAKRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FHDRRLQYTEHQQLEGWKWNRPGDRLLDLDIPMSVGIIDTRTNPSQLNAVEFLWDPAKRT 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 SAFIQVHCISTEFTPRKHGGEKGVPFRIQVDTFKQNENGEYTDHLHSASCQIKVFKPKGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SAFIQVHCISTEFTPRKHGGEKGVPFRIQVDTFKQNENGEYTDHLHSASCQIKVFKPKGA 190 200 210 220 230 240 250 260 270 pF1KB7 DRKQKTDREKMEKRTAHEKEKYQPSYDTTILTE--------------------------- ::::::::::::::::::::::::::::::::: NP_001 DRKQKTDREKMEKRTAHEKEKYQPSYDTTILTEMRLEPIIEDAVEHEQKKSSKRTLPADY 250 260 270 280 290 300 280 290 300 310 320 pF1KB7 ---------CSPWPDAPTAYVNNSPSPAPTFTSPQQSTCSVPDSNSSSPNHQGDGASQTS ::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GDSLAKRGSCSPWPDAPTAYVNNSPSPAPTFTSPQQSTCSVPDSNSSSPNHQGDGASQTS 310 320 330 340 350 360 330 340 350 360 370 380 pF1KB7 GEQIQPSATIQETQQWLLKNRFSSYTRLFSNFSGADLLKLTKEDLVQICGAADGIRLYNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GEQIQPSATIQETQQWLLKNRFSSYTRLFSNFSGADLLKLTKEDLVQICGAADGIRLYNS 370 380 390 400 410 420 390 400 410 420 430 440 pF1KB7 LKSRSVRPRLTIYVCREQPSSTVLQGQQQAASSASENGSGAPYVYHAIYLEEMIASEVAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LKSRSVRPRLTIYVCREQPSSTVLQGQQQAASSASENGSGAPYVYHAIYLEEMIASEVAR 430 440 450 460 470 480 450 460 470 480 490 500 pF1KB7 KLALVFNIPLHQINQVYRQGPTGIHILVSDQMVQNFQDESCFLFSTVKAESSDGIHIILK :::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KLALVFNIPLHQINQVYRQGPTGIHILVSDQMVQNFQDESCFLFSTVKAESSDGIHIILK 490 500 510 520 530 540 >>NP_055332 (OMIM: 609784) upstream-binding protein 1 is (540 aa) initn: 3362 init1: 1847 opt: 1867 Z-score: 1659.6 bits: 316.7 E(85289): 1.1e-85 Smith-Waterman score: 3273; 93.3% identity (93.3% similar) in 536 aa overlap (1-500:1-536) 10 20 30 40 50 60 pF1KB7 MAWVLKMDEVIESGLVHDFDASLSGIGQELGAGAYSMSDVLALPIFKQEDSSLPLDGETE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 MAWVLKMDEVIESGLVHDFDASLSGIGQELGAGAYSMSDVLALPIFKQEDSSLPLDGETE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 HPPFQYVMCAATSPAVKLHDETLTYLNQGQSYEIRMLDNRKMGDMPEINGKLVKSIIRVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 HPPFQYVMCAATSPAVKLHDETLTYLNQGQSYEIRMLDNRKMGDMPEINGKLVKSIIRVV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 FHDRRLQYTEHQQLEGWKWNRPGDRLLDLDIPMSVGIIDTRTNPSQLNAVEFLWDPAKRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 FHDRRLQYTEHQQLEGWKWNRPGDRLLDLDIPMSVGIIDTRTNPSQLNAVEFLWDPAKRT 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 SAFIQVHCISTEFTPRKHGGEKGVPFRIQVDTFKQNENGEYTDHLHSASCQIKVFKPKGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 SAFIQVHCISTEFTPRKHGGEKGVPFRIQVDTFKQNENGEYTDHLHSASCQIKVFKPKGA 190 200 210 220 230 240 250 260 270 pF1KB7 DRKQKTDREKMEKRTAHEKEKYQPSYDTTILTE--------------------------- ::::::::::::::::::::::::::::::::: NP_055 DRKQKTDREKMEKRTAHEKEKYQPSYDTTILTEMRLEPIIEDAVEHEQKKSSKRTLPADY 250 260 270 280 290 300 280 290 300 310 320 pF1KB7 ---------CSPWPDAPTAYVNNSPSPAPTFTSPQQSTCSVPDSNSSSPNHQGDGASQTS ::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 GDSLAKRGSCSPWPDAPTAYVNNSPSPAPTFTSPQQSTCSVPDSNSSSPNHQGDGASQTS 310 320 330 340 350 360 330 340 350 360 370 380 pF1KB7 GEQIQPSATIQETQQWLLKNRFSSYTRLFSNFSGADLLKLTKEDLVQICGAADGIRLYNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 GEQIQPSATIQETQQWLLKNRFSSYTRLFSNFSGADLLKLTKEDLVQICGAADGIRLYNS 370 380 390 400 410 420 390 400 410 420 430 440 pF1KB7 LKSRSVRPRLTIYVCREQPSSTVLQGQQQAASSASENGSGAPYVYHAIYLEEMIASEVAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 LKSRSVRPRLTIYVCREQPSSTVLQGQQQAASSASENGSGAPYVYHAIYLEEMIASEVAR 430 440 450 460 470 480 450 460 470 480 490 500 pF1KB7 KLALVFNIPLHQINQVYRQGPTGIHILVSDQMVQNFQDESCFLFSTVKAESSDGIHIILK :::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 KLALVFNIPLHQINQVYRQGPTGIHILVSDQMVQNFQDESCFLFSTVKAESSDGIHIILK 490 500 510 520 530 540 >>XP_016859391 (OMIM: 609785) PREDICTED: transcription f (406 aa) initn: 1850 init1: 1446 opt: 1863 Z-score: 1657.9 bits: 316.0 E(85289): 1.3e-85 Smith-Waterman score: 1863; 69.4% identity (90.1% similar) in 395 aa overlap (32-425:16-402) 10 20 30 40 50 60 pF1KB7 AWVLKMDEVIESGLVHDFDASLSGIGQELGAGAYSMSDVLALPIFKQEDSSLPLDGETEH .:.: . :::::::::::. .: ..:.. XP_016 MLFWHTQPEHYNQHNSGSY-LRDVLALPIFKQEEPQLSPENEARL 10 20 30 40 70 80 90 100 110 120 pF1KB7 PPFQYVMCAATSPAVKLHDETLTYLNQGQSYEIRMLDNRKMGDMPEINGKLVKSIIRVVF ::.:::.:::::::::::.:::::::::::::::.:.:::.::. ..: : ::::::::: XP_016 PPLQYVLCAATSPAVKLHEETLTYLNQGQSYEIRLLENRKLGDFQDLNTKYVKSIIRVVF 50 60 70 80 90 100 130 140 150 160 170 180 pF1KB7 HDRRLQYTEHQQLEGWKWNRPGDRLLDLDIPMSVGIIDTRTNPSQLNAVEFLWDPAKRTS ::::::::::::::::.:.:::::.::.:::.::::.: :..:.::::::::::::::.: XP_016 HDRRLQYTEHQQLEGWRWSRPGDRILDIDIPLSVGILDPRASPTQLNAVEFLWDPAKRAS 110 120 130 140 150 160 190 200 210 220 230 240 pF1KB7 AFIQVHCISTEFTPRKHGGEKGVPFRIQVDTFKQNENGEYTDHLHSASCQIKVFKPKGAD ::::::::::::::::::::::::::.:.::::::::::::.:::::::::::::::::: XP_016 AFIQVHCISTEFTPRKHGGEKGVPFRVQIDTFKQNENGEYTEHLHSASCQIKVFKPKGAD 170 180 190 200 210 220 250 260 270 280 290 300 pF1KB7 RKQKTDREKMEKRTAHEKEKYQPSYDTTILTECSPWPDAPTAY-VNNSPSPAPTFTSPQQ :::::::::::::::.:::::::::.::::::::::::. :: ::..:::. . :: XP_016 RKQKTDREKMEKRTAQEKEKYQPSYETTILTECSPWPDV--AYQVNSAPSPSYN-GSP-- 230 240 250 260 270 310 320 330 340 350 360 pF1KB7 STCSVPDSNSSSPNHQGDGASQTSGEQIQPSATIQETQQWLLKNRFSSYTRLFSNFSGAD .. .. ..:.: :.: . : ...... :::.::..:::: .::::.. :::..::::: XP_016 NSFGLGEGNAS-PTHPVE-ALPVGSDHLLPSASIQDAQQWLHRNRFSQFCRLFASFSGAD 280 290 300 310 320 330 370 380 390 400 410 420 pF1KB7 LLKLTKEDLVQICGAADGIRLYNSLKSRSVRPRLTIYVCREQPSSTVLQGQQQAASSASE :::....::::::: ::::::.:..:.:.:::..:::::.: .. : :.. .:. :. XP_016 LLKMSRDDLVQICGPADGIRLFNAIKGRNVRPKMTIYVCQELEQNRVPLQQKRDGSGDSN 340 350 360 370 380 390 430 440 450 460 470 480 pF1KB7 NGSGAPYVYHAIYLEEMIASEVARKLALVFNIPLHQINQVYRQGPTGIHILVSDQMVQNF ..:: XP_016 LSDGAELPR 400 >>NP_055368 (OMIM: 609785) transcription factor CP2-like (479 aa) initn: 2156 init1: 1446 opt: 1854 Z-score: 1648.9 bits: 314.6 E(85289): 4.2e-85 Smith-Waterman score: 2176; 68.1% identity (89.2% similar) in 474 aa overlap (32-504:16-476) 10 20 30 40 50 60 pF1KB7 AWVLKMDEVIESGLVHDFDASLSGIGQELGAGAYSMSDVLALPIFKQEDSSLPLDGETEH .:.: . :::::::::::. .: ..:.. NP_055 MLFWHTQPEHYNQHNSGSY-LRDVLALPIFKQEEPQLSPENEARL 10 20 30 40 70 80 90 100 110 120 pF1KB7 PPFQYVMCAATSPAVKLHDETLTYLNQGQSYEIRMLDNRKMGDMPEINGKLVKSIIRVVF ::.:::.:::::::::::.:::::::::::::::.:.:::.::. ..: : ::::::::: NP_055 PPLQYVLCAATSPAVKLHEETLTYLNQGQSYEIRLLENRKLGDFQDLNTKYVKSIIRVVF 50 60 70 80 90 100 130 140 150 160 170 180 pF1KB7 HDRRLQYTEHQQLEGWKWNRPGDRLLDLDIPMSVGIIDTRTNPSQLNAVEFLWDPAKRTS ::::::::::::::::.:.:::::.::.:::.::::.: :..:.::::::::::::::.: NP_055 HDRRLQYTEHQQLEGWRWSRPGDRILDIDIPLSVGILDPRASPTQLNAVEFLWDPAKRAS 110 120 130 140 150 160 190 200 210 220 230 240 pF1KB7 AFIQVHCISTEFTPRKHGGEKGVPFRIQVDTFKQNENGEYTDHLHSASCQIKVFKPKGAD ::::::::::::::::::::::::::.:.::::::::::::.:::::::::::::::::: NP_055 AFIQVHCISTEFTPRKHGGEKGVPFRVQIDTFKQNENGEYTEHLHSASCQIKVFKPKGAD 170 180 190 200 210 220 250 260 270 280 290 300 pF1KB7 RKQKTDREKMEKRTAHEKEKYQPSYDTTILTECSPWPDAPTAY-VNNSPSPAPTFTSPQQ :::::::::::::::.:::::::::.:::::::::::: .:: ::..:::. . :: NP_055 RKQKTDREKMEKRTAQEKEKYQPSYETTILTECSPWPD--VAYQVNSAPSPSYN-GSP-- 230 240 250 260 270 310 320 330 340 350 360 pF1KB7 STCSVPDSNSSSPNHQGDGASQTSGEQIQPSATIQETQQWLLKNRFSSYTRLFSNFSGAD .. .. ..:.: :.: . : ...... :::.::..:::: .::::.. :::..::::: NP_055 NSFGLGEGNAS-PTHPVE-ALPVGSDHLLPSASIQDAQQWLHRNRFSQFCRLFASFSGAD 280 290 300 310 320 330 370 380 390 400 410 420 pF1KB7 LLKLTKEDLVQICGAADGIRLYNSLKSRSVRPRLTIYVCREQPSSTVLQGQQQAASSASE :::....::::::: ::::::.:..:.:.:::..:::::.: .. : ::. .:.. NP_055 LLKMSRDDLVQICGPADGIRLFNAIKGRNVRPKMTIYVCQELEQNRV-PLQQKRDGSGDS 340 350 360 370 380 390 430 440 450 460 470 480 pF1KB7 NGSGAPYVYHAIYLEEMIASEVARKLALVFNIPLHQINQVYRQGPTGIHILVSDQMVQNF : : :::::.:::. . :. .:.: ...: ..:..::::::::::..::..::::: NP_055 NLS----VYHAIFLEELTTLELIEKIANLYSISPQHIHRVYRQGPTGIHVVVSNEMVQNF 400 410 420 430 440 450 490 500 pF1KB7 QDESCFLFSTVKAESSDGIHIILK ::::::..::.::::.:: ::::: NP_055 QDESCFVLSTIKAESNDGYHIILKCGL 460 470 >>XP_016859393 (OMIM: 609785) PREDICTED: transcription f (273 aa) initn: 1417 init1: 1389 opt: 1399 Z-score: 1250.5 bits: 240.0 E(85289): 6.4e-63 Smith-Waterman score: 1399; 79.3% identity (92.6% similar) in 256 aa overlap (32-279:16-270) 10 20 30 40 50 60 pF1KB7 AWVLKMDEVIESGLVHDFDASLSGIGQELGAGAYSMSDVLALPIFKQEDSSLPLDGETEH .:.: . :::::::::::. .: ..:.. XP_016 MLFWHTQPEHYNQHNSGSY-LRDVLALPIFKQEEPQLSPENEARL 10 20 30 40 70 80 90 100 110 120 pF1KB7 PPFQYVMCAATSPAVKLHDETLTYLNQGQSYEIRMLDNRKMGDMPEINGKLVKSIIRVVF ::.:::.:::::::::::.:::::::::::::::.:.:::.::. ..: : ::::::::: XP_016 PPLQYVLCAATSPAVKLHEETLTYLNQGQSYEIRLLENRKLGDFQDLNTKYVKSIIRVVF 50 60 70 80 90 100 130 140 150 160 170 180 pF1KB7 HDRRLQYTEHQQLEGWKWNRPGDRLLDLDIPMSVGIIDTRTNPSQLNAVEFLWDPAKRTS ::::::::::::::::.:.:::::.::.:::.::::.: :..:.::::::::::::::.: XP_016 HDRRLQYTEHQQLEGWRWSRPGDRILDIDIPLSVGILDPRASPTQLNAVEFLWDPAKRAS 110 120 130 140 150 160 190 200 210 220 230 240 pF1KB7 AFIQVHCISTEFTPRKHGGEKGVPFRIQVDTFKQNENGEYTDHLHSASCQIKVFKPKGAD ::::::::::::::::::::::::::.:.::::::::::::.:::::::::::::::::: XP_016 AFIQVHCISTEFTPRKHGGEKGVPFRVQIDTFKQNENGEYTEHLHSASCQIKVFKPKGAD 170 180 190 200 210 220 250 260 270 280 290 pF1KB7 RKQKTDREKMEKRTAHEKEKYQPSYDTTILTE----CS----PWPDAPTAYVNNSPSPAP :::::::::::::::.:::::::::.:::::: :: :: . XP_016 RKQKTDREKMEKRTAQEKEKYQPSYETTILTEPQPLCSSADCPWEERSW 230 240 250 260 270 300 310 320 330 340 350 pF1KB7 TFTSPQQSTCSVPDSNSSSPNHQGDGASQTSGEQIQPSATIQETQQWLLKNRFSSYTRLF >>XP_016859394 (OMIM: 609785) PREDICTED: transcription f (273 aa) initn: 1385 init1: 1385 opt: 1391 Z-score: 1243.5 bits: 238.7 E(85289): 1.6e-62 Smith-Waterman score: 1391; 82.2% identity (95.9% similar) in 242 aa overlap (32-273:16-256) 10 20 30 40 50 60 pF1KB7 AWVLKMDEVIESGLVHDFDASLSGIGQELGAGAYSMSDVLALPIFKQEDSSLPLDGETEH .:.: . :::::::::::. .: ..:.. XP_016 MLFWHTQPEHYNQHNSGSY-LRDVLALPIFKQEEPQLSPENEARL 10 20 30 40 70 80 90 100 110 120 pF1KB7 PPFQYVMCAATSPAVKLHDETLTYLNQGQSYEIRMLDNRKMGDMPEINGKLVKSIIRVVF ::.:::.:::::::::::.:::::::::::::::.:.:::.::. ..: : ::::::::: XP_016 PPLQYVLCAATSPAVKLHEETLTYLNQGQSYEIRLLENRKLGDFQDLNTKYVKSIIRVVF 50 60 70 80 90 100 130 140 150 160 170 180 pF1KB7 HDRRLQYTEHQQLEGWKWNRPGDRLLDLDIPMSVGIIDTRTNPSQLNAVEFLWDPAKRTS ::::::::::::::::.:.:::::.::.:::.::::.: :..:.::::::::::::::.: XP_016 HDRRLQYTEHQQLEGWRWSRPGDRILDIDIPLSVGILDPRASPTQLNAVEFLWDPAKRAS 110 120 130 140 150 160 190 200 210 220 230 240 pF1KB7 AFIQVHCISTEFTPRKHGGEKGVPFRIQVDTFKQNENGEYTDHLHSASCQIKVFKPKGAD ::::::::::::::::::::::::::.:.::::::::::::.:::::::::::::::::: XP_016 AFIQVHCISTEFTPRKHGGEKGVPFRVQIDTFKQNENGEYTEHLHSASCQIKVFKPKGAD 170 180 190 200 210 220 250 260 270 280 290 300 pF1KB7 RKQKTDREKMEKRTAHEKEKYQPSYDTTILTECSPWPDAPTAYVNNSPSPAPTFTSPQQS :::::::::::::::.:::::::::.:::::: XP_016 RKQKTDREKMEKRTAQEKEKYQPSYETTILTEEAQRDPLGTSLAPGVTY 230 240 250 260 270 310 320 330 340 350 360 pF1KB7 TCSVPDSNSSSPNHQGDGASQTSGEQIQPSATIQETQQWLLKNRFSSYTRLFSNFSGADL >>NP_001166924 (OMIM: 189889) alpha-globin transcription (450 aa) initn: 1850 init1: 1074 opt: 1099 Z-score: 982.2 bits: 191.1 E(85289): 5.7e-48 Smith-Waterman score: 2057; 64.0% identity (80.4% similar) in 509 aa overlap (1-504:1-450) 10 20 30 40 50 pF1KB7 MAWVLKM---DEVIESGLVHDFDASLSGIGQELGAGAYSMSDVLALPIFKQEDSSLPLDG :::.::. :::::::::.::::::::::::::::::::::::::::::::.:::: :. NP_001 MAWALKLPLADEVIESGLVQDFDASLSGIGQELGAGAYSMSDVLALPIFKQEESSLPPDN 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB7 ETEHPPFQYVMCAATSPAVKLHDETLTYLNQGQSYEIRMLDNRKMGDMPEINGKLVKSII :.. :::::.:::::::::::::::::::::::::::::::::.:..:::::::::::. NP_001 ENKILPFQYVLCAATSPAVKLHDETLTYLNQGQSYEIRMLDNRKLGELPEINGKLVKSIF 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB7 RVVFHDRRLQYTEHQQLEGWKWNRPGDRLLDLDIPMSVGIIDTRTNPSQLNAVEFLWDPA ::::::::::::::::::::.:::::::.::.:::::::::: :.::.:::.:::::::: NP_001 RVVFHDRRLQYTEHQQLEGWRWNRPGDRILDIDIPMSVGIIDPRANPTQLNTVEFLWDPA 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB7 KRTSAFIQVHCISTEFTPRKHGGEKGVPFRIQVDTFKQNENGEYTDHLHSASCQIKVFKP ::::.::: : NP_001 KRTSVFIQ---------------------------------------------------P 240 250 260 270 280 290 pF1KB7 KGADRKQKTDREKMEKRTAHEKEKYQPSYDTTILTECSPWPDAPTAYVNNSPSPAPTFTS :::::::::::::::::: ::::::::::.:::::::::::. .::::::::. :.: NP_001 KGADRKQKTDREKMEKRTPHEKEKYQPSYETTILTECSPWPE--ITYVNNSPSPG--FNS 190 200 210 220 230 240 300 310 320 330 340 350 pF1KB7 PQQSTCSVPDSNSSSPNHQGDGASQTSGEQIQPSATIQETQQWLLKNRFSSYTRLFSNFS ..:. :. ..:.: :::: . .. ... :..: ::.:::: .::::..::::.::: NP_001 -SHSSFSLGEGNGS-PNHQPEPPPPVT-DNLLPTTTPQEAQQWLHRNRFSTFTRLFTNFS 250 260 270 280 290 300 360 370 380 390 400 410 pF1KB7 GADLLKLTKEDLVQICGAADGIRLYNSLKSRSVRPRLTIYVCREQPSSTVLQGQQQAASS ::::::::..:..:::: ::::::.:.::.: ::::::::::.:. . : ::: .. NP_001 GADLLKLTRDDVIQICGPADGIRLFNALKGRMVRPRLTIYVCQESLQLREQQQQQQQQQQ 310 320 330 340 350 360 420 430 440 450 460 470 pF1KB7 ASENG--SGAPYVYHAIYLEEMIASEVARKLALVFNIPLHQINQVYRQGPTGIHILVSDQ :.: .:. .:::::::::. : :...:.: .:.: ::.:.:.:::::::.:.::. NP_001 KHEDGDSNGTFFVYHAIYLEELTAVELTEKIAQLFSISPCQISQIYKQGPTGIHVLISDE 370 380 390 400 410 420 480 490 500 pF1KB7 MVQNFQDESCFLFSTVKAESSDGIHIILK :.::::.:.::...:.: :..:. ::::: NP_001 MIQNFQEEACFILDTMK-ETNDSYHIILK 430 440 450 504 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 09:52:07 2016 done: Sat Nov 5 09:52:08 2016 Total Scan time: 9.040 Total Display time: 0.070 Function used was FASTA [36.3.4 Apr, 2011]