FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB7920, 346 aa 1>>>pF1KB7920 346 - 346 aa - 346 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.4607+/-0.000437; mu= 14.8831+/- 0.027 mean_var=59.9211+/-11.671, 0's: 0 Z-trim(109.7): 12 B-trim: 18 in 1/51 Lambda= 0.165685 statistics sampled from 17910 (17915) to 17910 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.59), E-opt: 0.2 (0.21), width: 16 Scan time: 7.310 The best scores are: opt bits E(85289) NP_976035 (OMIM: 248390,610060,616494) DNA-directe ( 346) 2292 556.6 2.8e-158 XP_011513302 (OMIM: 248390,610060,616494) PREDICTE ( 307) 2040 496.4 3.4e-140 NP_001305805 (OMIM: 248390,610060,616494) DNA-dire ( 342) 2040 496.4 3.8e-140 NP_116558 (OMIM: 180663) DNA-directed RNA polymera ( 275) 344 91.0 3.4e-18 >>NP_976035 (OMIM: 248390,610060,616494) DNA-directed RN (346 aa) initn: 2292 init1: 2292 opt: 2292 Z-score: 2962.6 bits: 556.6 E(85289): 2.8e-158 Smith-Waterman score: 2292; 100.0% identity (100.0% similar) in 346 aa overlap (1-346:1-346) 10 20 30 40 50 60 pF1KB7 MAASQAVEEMRSRVVLGEFGVRNVHTTDFPGNYSGYDDAWDQDRFEKNFRVDVVHMDENS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_976 MAASQAVEEMRSRVVLGEFGVRNVHTTDFPGNYSGYDDAWDQDRFEKNFRVDVVHMDENS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 LEFDMVGIDAAIANAFRRILLAEVPTMAVEKVLVYNNTSIVQDEILAHRLGLIPIHADPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_976 LEFDMVGIDAAIANAFRRILLAEVPTMAVEKVLVYNNTSIVQDEILAHRLGLIPIHADPR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 LFEYRNQGDEEGTEIDTLQFRLQVRCTRNPHAAKDSSDPNELYVNHKVYTRHMTWIPLGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_976 LFEYRNQGDEEGTEIDTLQFRLQVRCTRNPHAAKDSSDPNELYVNHKVYTRHMTWIPLGN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 QADLFPEGTIRPVHDDILIAQLRPGQEIDLLMHCVKGIGKDHAKFSPVATASYRLLPDIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_976 QADLFPEGTIRPVHDDILIAQLRPGQEIDLLMHCVKGIGKDHAKFSPVATASYRLLPDIT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 LLEPVEGEAAEELSRCFSPGVIEVQEVQGKKVARVANPRLDTFSREIFRNEKLKKVVRLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_976 LLEPVEGEAAEELSRCFSPGVIEVQEVQGKKVARVANPRLDTFSREIFRNEKLKKVVRLA 250 260 270 280 290 300 310 320 330 340 pF1KB7 RVRDHYIFSVESTGVLPPDVLVSEAIKVLMGKCRRFLDELDAVQMD :::::::::::::::::::::::::::::::::::::::::::::: NP_976 RVRDHYIFSVESTGVLPPDVLVSEAIKVLMGKCRRFLDELDAVQMD 310 320 330 340 >>XP_011513302 (OMIM: 248390,610060,616494) PREDICTED: D (307 aa) initn: 2040 init1: 2040 opt: 2040 Z-score: 2637.9 bits: 496.4 E(85289): 3.4e-140 Smith-Waterman score: 2040; 100.0% identity (100.0% similar) in 307 aa overlap (1-307:1-307) 10 20 30 40 50 60 pF1KB7 MAASQAVEEMRSRVVLGEFGVRNVHTTDFPGNYSGYDDAWDQDRFEKNFRVDVVHMDENS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MAASQAVEEMRSRVVLGEFGVRNVHTTDFPGNYSGYDDAWDQDRFEKNFRVDVVHMDENS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 LEFDMVGIDAAIANAFRRILLAEVPTMAVEKVLVYNNTSIVQDEILAHRLGLIPIHADPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LEFDMVGIDAAIANAFRRILLAEVPTMAVEKVLVYNNTSIVQDEILAHRLGLIPIHADPR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 LFEYRNQGDEEGTEIDTLQFRLQVRCTRNPHAAKDSSDPNELYVNHKVYTRHMTWIPLGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LFEYRNQGDEEGTEIDTLQFRLQVRCTRNPHAAKDSSDPNELYVNHKVYTRHMTWIPLGN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 QADLFPEGTIRPVHDDILIAQLRPGQEIDLLMHCVKGIGKDHAKFSPVATASYRLLPDIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QADLFPEGTIRPVHDDILIAQLRPGQEIDLLMHCVKGIGKDHAKFSPVATASYRLLPDIT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 LLEPVEGEAAEELSRCFSPGVIEVQEVQGKKVARVANPRLDTFSREIFRNEKLKKVVRLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LLEPVEGEAAEELSRCFSPGVIEVQEVQGKKVARVANPRLDTFSREIFRNEKLKKVVRLA 250 260 270 280 290 300 310 320 330 340 pF1KB7 RVRDHYIFSVESTGVLPPDVLVSEAIKVLMGKCRRFLDELDAVQMD ::::::: XP_011 RVRDHYI >>NP_001305805 (OMIM: 248390,610060,616494) DNA-directed (342 aa) initn: 2040 init1: 2040 opt: 2040 Z-score: 2637.1 bits: 496.4 E(85289): 3.8e-140 Smith-Waterman score: 2040; 100.0% identity (100.0% similar) in 307 aa overlap (1-307:1-307) 10 20 30 40 50 60 pF1KB7 MAASQAVEEMRSRVVLGEFGVRNVHTTDFPGNYSGYDDAWDQDRFEKNFRVDVVHMDENS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAASQAVEEMRSRVVLGEFGVRNVHTTDFPGNYSGYDDAWDQDRFEKNFRVDVVHMDENS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 LEFDMVGIDAAIANAFRRILLAEVPTMAVEKVLVYNNTSIVQDEILAHRLGLIPIHADPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LEFDMVGIDAAIANAFRRILLAEVPTMAVEKVLVYNNTSIVQDEILAHRLGLIPIHADPR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 LFEYRNQGDEEGTEIDTLQFRLQVRCTRNPHAAKDSSDPNELYVNHKVYTRHMTWIPLGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LFEYRNQGDEEGTEIDTLQFRLQVRCTRNPHAAKDSSDPNELYVNHKVYTRHMTWIPLGN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 QADLFPEGTIRPVHDDILIAQLRPGQEIDLLMHCVKGIGKDHAKFSPVATASYRLLPDIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QADLFPEGTIRPVHDDILIAQLRPGQEIDLLMHCVKGIGKDHAKFSPVATASYRLLPDIT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 LLEPVEGEAAEELSRCFSPGVIEVQEVQGKKVARVANPRLDTFSREIFRNEKLKKVVRLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLEPVEGEAAEELSRCFSPGVIEVQEVQGKKVARVANPRLDTFSREIFRNEKLKKVVRLA 250 260 270 280 290 300 310 320 330 340 pF1KB7 RVRDHYIFSVESTGVLPPDVLVSEAIKVLMGKCRRFLDELDAVQMD ::::::: NP_001 RVRDHYICKKDLLAAVAHTCNPSTLGGQGEWITGSRERDHPG 310 320 330 340 >>NP_116558 (OMIM: 180663) DNA-directed RNA polymerase I (275 aa) initn: 354 init1: 185 opt: 344 Z-score: 447.7 bits: 91.0 E(85289): 3.4e-18 Smith-Waterman score: 344; 32.7% identity (64.9% similar) in 205 aa overlap (51-251:9-202) 30 40 50 60 70 80 pF1KB7 VRNVHTTDFPGNYSGYDDAWDQDRFEKNFRVDVVHMDENSLEFDMVGIDAAIANAFRRIL : .... .....: . . : :.::..::.. NP_116 MPYANQPTVRITELTDENVKFIIENTDLAVANSIRRVF 10 20 30 90 100 110 120 130 pF1KB7 LAEVPTMAVEKVLVYNNTSIVQDEILAHRLGLIPIHADP---RLFEYRNQGDEEGTEIDT .:::: .:.. : . :.:...::..::::::::. .: .: :. :: . NP_116 IAEVPIIAIDWVQIDANSSVLHDEFIAHRLGLIPLISDDIVDKLQYSRDCTCEEFCPECS 40 50 60 70 80 90 140 150 160 170 180 190 pF1KB7 LQFRLQVRCTRNPHAAKDSSDPNELYVNHKVYTRHMTWIPLGNQA-DLFPEGTIRPVHDD ..: :.::: : .. .. . . . .: ::. .. : :. .. .:: NP_116 VEFTLDVRC--NEDQTRHVTSRDLISNSPRV-------IPVTSRNRDNDPNDYVE--QDD 100 110 120 130 140 200 210 220 230 240 250 pF1KB7 ILIAQLRPGQEIDLLMHCVKGIGKDHAKFSPVATASYRLLPDITLLEPVEGEAAEELSRC :::..:: :::. : . ::.::.:::..:.: .... :: .: . : . : NP_116 ILIVKLRKGQELRLRAYAKKGFGKEHAKWNPTAGVAFEYDPDNALRHTVYPKPEEWPKSE 150 160 170 180 190 200 260 270 280 290 300 310 pF1KB7 FSPGVIEVQEVQGKKVARVANPRLDTFSREIFRNEKLKKVVRLARVRDHYIFSVESTGVL NP_116 YSELDEDESQAPYDPNGKPERFYYNVESCGSLRPETIVLSALSGLKKKLSDLQTQLSHEI 210 220 230 240 250 260 346 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 14:37:52 2016 done: Sat Nov 5 14:37:53 2016 Total Scan time: 7.310 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]