FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB7921, 181 aa 1>>>pF1KB7921 181 - 181 aa - 181 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.6584+/-0.000326; mu= 7.9201+/- 0.021 mean_var=141.4260+/-27.870, 0's: 0 Z-trim(120.3): 110 B-trim: 1124 in 1/60 Lambda= 0.107847 statistics sampled from 35244 (35393) to 35244 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.77), E-opt: 0.2 (0.415), width: 16 Scan time: 6.430 The best scores are: opt bits E(85289) XP_011507881 (OMIM: 603148) PREDICTED: cyclic AMP- ( 181) 1171 192.7 2.8e-49 XP_005273203 (OMIM: 603148) PREDICTED: cyclic AMP- ( 181) 1171 192.7 2.8e-49 NP_001665 (OMIM: 603148) cyclic AMP-dependent tran ( 181) 1171 192.7 2.8e-49 NP_001025458 (OMIM: 603148) cyclic AMP-dependent t ( 181) 1171 192.7 2.8e-49 NP_001193413 (OMIM: 603148) cyclic AMP-dependent t ( 124) 785 132.5 2.5e-31 NP_001193417 (OMIM: 603148) cyclic AMP-dependent t ( 124) 785 132.5 2.5e-31 NP_001035709 (OMIM: 603148) cyclic AMP-dependent t ( 135) 756 128.0 6.2e-30 NP_001193415 (OMIM: 603148) cyclic AMP-dependent t ( 106) 478 84.6 5.4e-17 XP_016876460 (OMIM: 608657) PREDICTED: jun dimeriz ( 206) 437 78.5 7.3e-15 XP_016876461 (OMIM: 608657) PREDICTED: jun dimeriz ( 174) 435 78.1 8e-15 NP_001128521 (OMIM: 608657) jun dimerization prote ( 174) 435 78.1 8e-15 NP_569736 (OMIM: 608657) jun dimerization protein ( 163) 430 77.3 1.3e-14 XP_005267389 (OMIM: 608657) PREDICTED: jun dimeriz ( 163) 430 77.3 1.3e-14 XP_016876463 (OMIM: 608657) PREDICTED: jun dimeriz ( 163) 430 77.3 1.3e-14 NP_001128520 (OMIM: 608657) jun dimerization prote ( 163) 430 77.3 1.3e-14 NP_001128519 (OMIM: 608657) jun dimerization prote ( 163) 430 77.3 1.3e-14 XP_016876462 (OMIM: 608657) PREDICTED: jun dimeriz ( 163) 430 77.3 1.3e-14 XP_016876464 (OMIM: 608657) PREDICTED: jun dimeriz ( 163) 430 77.3 1.3e-14 NP_001287785 (OMIM: 136515) fos-related antigen 1 ( 205) 279 53.9 1.8e-07 NP_005429 (OMIM: 136515) fos-related antigen 1 iso ( 271) 279 54.1 2.2e-07 XP_016859226 (OMIM: 601575) PREDICTED: fos-related ( 287) 278 53.9 2.6e-07 NP_005244 (OMIM: 601575) fos-related antigen 2 [Ho ( 326) 278 54.0 2.8e-07 XP_005258748 (OMIM: 164772) PREDICTED: protein fos ( 237) 274 53.2 3.5e-07 NP_006723 (OMIM: 164772) protein fosB isoform 1 [H ( 338) 274 53.4 4.5e-07 NP_005243 (OMIM: 164810) proto-oncogene c-Fos [Hom ( 380) 260 51.2 2.2e-06 NP_006390 (OMIM: 612476) basic leucine zipper tran ( 125) 208 42.7 0.00027 NP_061134 (OMIM: 612470) basic leucine zipper tran ( 127) 199 41.3 0.00072 NP_001243022 (OMIM: 123811) cyclic AMP-dependent t ( 374) 183 39.3 0.0088 NP_001243021 (OMIM: 123811) cyclic AMP-dependent t ( 447) 184 39.5 0.009 NP_001243020 (OMIM: 123811) cyclic AMP-dependent t ( 487) 184 39.5 0.0096 NP_001243019 (OMIM: 123811) cyclic AMP-dependent t ( 505) 184 39.5 0.0098 NP_001871 (OMIM: 123811) cyclic AMP-dependent tran ( 505) 184 39.5 0.0098 >>XP_011507881 (OMIM: 603148) PREDICTED: cyclic AMP-depe (181 aa) initn: 1171 init1: 1171 opt: 1171 Z-score: 1005.8 bits: 192.7 E(85289): 2.8e-49 Smith-Waterman score: 1171; 100.0% identity (100.0% similar) in 181 aa overlap (1-181:1-181) 10 20 30 40 50 60 pF1KB7 MMLQHPGQVSASEVSASAIVPCLSPPGSLVFEDFANLTPFVKEELRFAIQNKHLCHRMSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MMLQHPGQVSASEVSASAIVPCLSPPGSLVFEDFANLTPFVKEELRFAIQNKHLCHRMSS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 ALESVTVSDRPLGVSITKAEVAPEEDERKKRRRERNKIAAAKCRNKKKEKTECLQKESEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ALESVTVSDRPLGVSITKAEVAPEEDERKKRRRERNKIAAAKCRNKKKEKTECLQKESEK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 LESVNAELKAQIEELKNEKQHLIYMLNLHRPTCIVRAQNGRTPEDERNLFIQQIKEGTLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LESVNAELKAQIEELKNEKQHLIYMLNLHRPTCIVRAQNGRTPEDERNLFIQQIKEGTLQ 130 140 150 160 170 180 pF1KB7 S : XP_011 S >>XP_005273203 (OMIM: 603148) PREDICTED: cyclic AMP-depe (181 aa) initn: 1171 init1: 1171 opt: 1171 Z-score: 1005.8 bits: 192.7 E(85289): 2.8e-49 Smith-Waterman score: 1171; 100.0% identity (100.0% similar) in 181 aa overlap (1-181:1-181) 10 20 30 40 50 60 pF1KB7 MMLQHPGQVSASEVSASAIVPCLSPPGSLVFEDFANLTPFVKEELRFAIQNKHLCHRMSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MMLQHPGQVSASEVSASAIVPCLSPPGSLVFEDFANLTPFVKEELRFAIQNKHLCHRMSS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 ALESVTVSDRPLGVSITKAEVAPEEDERKKRRRERNKIAAAKCRNKKKEKTECLQKESEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ALESVTVSDRPLGVSITKAEVAPEEDERKKRRRERNKIAAAKCRNKKKEKTECLQKESEK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 LESVNAELKAQIEELKNEKQHLIYMLNLHRPTCIVRAQNGRTPEDERNLFIQQIKEGTLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LESVNAELKAQIEELKNEKQHLIYMLNLHRPTCIVRAQNGRTPEDERNLFIQQIKEGTLQ 130 140 150 160 170 180 pF1KB7 S : XP_005 S >>NP_001665 (OMIM: 603148) cyclic AMP-dependent transcri (181 aa) initn: 1171 init1: 1171 opt: 1171 Z-score: 1005.8 bits: 192.7 E(85289): 2.8e-49 Smith-Waterman score: 1171; 100.0% identity (100.0% similar) in 181 aa overlap (1-181:1-181) 10 20 30 40 50 60 pF1KB7 MMLQHPGQVSASEVSASAIVPCLSPPGSLVFEDFANLTPFVKEELRFAIQNKHLCHRMSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MMLQHPGQVSASEVSASAIVPCLSPPGSLVFEDFANLTPFVKEELRFAIQNKHLCHRMSS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 ALESVTVSDRPLGVSITKAEVAPEEDERKKRRRERNKIAAAKCRNKKKEKTECLQKESEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ALESVTVSDRPLGVSITKAEVAPEEDERKKRRRERNKIAAAKCRNKKKEKTECLQKESEK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 LESVNAELKAQIEELKNEKQHLIYMLNLHRPTCIVRAQNGRTPEDERNLFIQQIKEGTLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LESVNAELKAQIEELKNEKQHLIYMLNLHRPTCIVRAQNGRTPEDERNLFIQQIKEGTLQ 130 140 150 160 170 180 pF1KB7 S : NP_001 S >>NP_001025458 (OMIM: 603148) cyclic AMP-dependent trans (181 aa) initn: 1171 init1: 1171 opt: 1171 Z-score: 1005.8 bits: 192.7 E(85289): 2.8e-49 Smith-Waterman score: 1171; 100.0% identity (100.0% similar) in 181 aa overlap (1-181:1-181) 10 20 30 40 50 60 pF1KB7 MMLQHPGQVSASEVSASAIVPCLSPPGSLVFEDFANLTPFVKEELRFAIQNKHLCHRMSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MMLQHPGQVSASEVSASAIVPCLSPPGSLVFEDFANLTPFVKEELRFAIQNKHLCHRMSS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 ALESVTVSDRPLGVSITKAEVAPEEDERKKRRRERNKIAAAKCRNKKKEKTECLQKESEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ALESVTVSDRPLGVSITKAEVAPEEDERKKRRRERNKIAAAKCRNKKKEKTECLQKESEK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 LESVNAELKAQIEELKNEKQHLIYMLNLHRPTCIVRAQNGRTPEDERNLFIQQIKEGTLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LESVNAELKAQIEELKNEKQHLIYMLNLHRPTCIVRAQNGRTPEDERNLFIQQIKEGTLQ 130 140 150 160 170 180 pF1KB7 S : NP_001 S >>NP_001193413 (OMIM: 603148) cyclic AMP-dependent trans (124 aa) initn: 785 init1: 785 opt: 785 Z-score: 683.3 bits: 132.5 E(85289): 2.5e-31 Smith-Waterman score: 785; 100.0% identity (100.0% similar) in 124 aa overlap (58-181:1-124) 30 40 50 60 70 80 pF1KB7 SLVFEDFANLTPFVKEELRFAIQNKHLCHRMSSALESVTVSDRPLGVSITKAEVAPEEDE :::::::::::::::::::::::::::::: NP_001 MSSALESVTVSDRPLGVSITKAEVAPEEDE 10 20 30 90 100 110 120 130 140 pF1KB7 RKKRRRERNKIAAAKCRNKKKEKTECLQKESEKLESVNAELKAQIEELKNEKQHLIYMLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RKKRRRERNKIAAAKCRNKKKEKTECLQKESEKLESVNAELKAQIEELKNEKQHLIYMLN 40 50 60 70 80 90 150 160 170 180 pF1KB7 LHRPTCIVRAQNGRTPEDERNLFIQQIKEGTLQS :::::::::::::::::::::::::::::::::: NP_001 LHRPTCIVRAQNGRTPEDERNLFIQQIKEGTLQS 100 110 120 >>NP_001193417 (OMIM: 603148) cyclic AMP-dependent trans (124 aa) initn: 785 init1: 785 opt: 785 Z-score: 683.3 bits: 132.5 E(85289): 2.5e-31 Smith-Waterman score: 785; 100.0% identity (100.0% similar) in 124 aa overlap (58-181:1-124) 30 40 50 60 70 80 pF1KB7 SLVFEDFANLTPFVKEELRFAIQNKHLCHRMSSALESVTVSDRPLGVSITKAEVAPEEDE :::::::::::::::::::::::::::::: NP_001 MSSALESVTVSDRPLGVSITKAEVAPEEDE 10 20 30 90 100 110 120 130 140 pF1KB7 RKKRRRERNKIAAAKCRNKKKEKTECLQKESEKLESVNAELKAQIEELKNEKQHLIYMLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RKKRRRERNKIAAAKCRNKKKEKTECLQKESEKLESVNAELKAQIEELKNEKQHLIYMLN 40 50 60 70 80 90 150 160 170 180 pF1KB7 LHRPTCIVRAQNGRTPEDERNLFIQQIKEGTLQS :::::::::::::::::::::::::::::::::: NP_001 LHRPTCIVRAQNGRTPEDERNLFIQQIKEGTLQS 100 110 120 >>NP_001035709 (OMIM: 603148) cyclic AMP-dependent trans (135 aa) initn: 756 init1: 756 opt: 756 Z-score: 658.4 bits: 128.0 E(85289): 6.2e-30 Smith-Waterman score: 756; 100.0% identity (100.0% similar) in 116 aa overlap (1-116:1-116) 10 20 30 40 50 60 pF1KB7 MMLQHPGQVSASEVSASAIVPCLSPPGSLVFEDFANLTPFVKEELRFAIQNKHLCHRMSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MMLQHPGQVSASEVSASAIVPCLSPPGSLVFEDFANLTPFVKEELRFAIQNKHLCHRMSS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 ALESVTVSDRPLGVSITKAEVAPEEDERKKRRRERNKIAAAKCRNKKKEKTECLQKESEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ALESVTVSDRPLGVSITKAEVAPEEDERKKRRRERNKIAAAKCRNKKKEKTECLQKLPRP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 LESVNAELKAQIEELKNEKQHLIYMLNLHRPTCIVRAQNGRTPEDERNLFIQQIKEGTLQ NP_001 FWVQKTCIWAVDSCK 130 >>NP_001193415 (OMIM: 603148) cyclic AMP-dependent trans (106 aa) initn: 478 init1: 478 opt: 478 Z-score: 426.0 bits: 84.6 E(85289): 5.4e-17 Smith-Waterman score: 496; 75.0% identity (75.0% similar) in 116 aa overlap (1-116:1-87) 10 20 30 40 50 60 pF1KB7 MMLQHPGQVSASEVSASAIVPCLSPPGSLVFEDFANLTPFVKEELRFAIQNKHLCHRMSS ::::::::::::: :::::::::::::::::: NP_001 MMLQHPGQVSASE-----------------------------EELRFAIQNKHLCHRMSS 10 20 30 70 80 90 100 110 120 pF1KB7 ALESVTVSDRPLGVSITKAEVAPEEDERKKRRRERNKIAAAKCRNKKKEKTECLQKESEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ALESVTVSDRPLGVSITKAEVAPEEDERKKRRRERNKIAAAKCRNKKKEKTECLQKLPRP 40 50 60 70 80 90 130 140 150 160 170 180 pF1KB7 LESVNAELKAQIEELKNEKQHLIYMLNLHRPTCIVRAQNGRTPEDERNLFIQQIKEGTLQ NP_001 FWVQKTCIWAVDSCK 100 >>XP_016876460 (OMIM: 608657) PREDICTED: jun dimerizatio (206 aa) initn: 550 init1: 419 opt: 437 Z-score: 387.8 bits: 78.5 E(85289): 7.3e-15 Smith-Waterman score: 445; 48.8% identity (73.3% similar) in 172 aa overlap (6-176:46-205) 10 20 30 pF1KB7 MMLQHPGQVSASEVSASAIVPCLSPPGSLVFEDFA :::. :..... : :.: .: XP_016 PMDIRSSLFCQIHLSPWEETGWPATPPAMMPGQIPDPSVTTGSL-PGLGPLTGL------ 20 30 40 50 60 40 50 60 70 80 90 pF1KB7 NLTPFVKEELRFA-IQNKHLCHRMSSALESVTVSDRPLGVSITKAEVAPEEDERKKRRRE . .. :::..: :.: :: : .. :: : :.:. ::.::.::::: XP_016 PSSALTVEELKYADIRNLGAMIAPLHFLE-VKLGKRPQPV---KSEL-DEEEERRKRRRE 70 80 90 100 110 120 100 110 120 130 140 150 pF1KB7 RNKIAAAKCRNKKKEKTECLQKESEKLESVNAELKAQIEELKNEKQHLIYMLNLHRPTCI .::.:::.:::::::.:: ::.:::.:: .:::::.::::::.:.:.:: ::: :::::: XP_016 KNKVAAARCRNKKKERTEFLQRESERLELMNAELKTQIEELKQERQQLILMLNRHRPTCI 130 140 150 160 170 180 160 170 180 pF1KB7 VRAQNGRTPEDERNLFIQQIKEGTLQS ::... .:::.: : ...:... XP_016 VRTDSVKTPESEGNPLLEQLEKK 190 200 >>XP_016876461 (OMIM: 608657) PREDICTED: jun dimerizatio (174 aa) initn: 550 init1: 419 opt: 435 Z-score: 387.1 bits: 78.1 E(85289): 8e-15 Smith-Waterman score: 445; 48.8% identity (73.3% similar) in 172 aa overlap (6-176:14-173) 10 20 30 40 50 pF1KB7 MMLQHPGQVSASEVSASAIVPCLSPPGSLVFEDFANLTPFVKEELRFA-IQN :::. :..... : :.: .: . .. :::..: :.: XP_016 MVAGWPATPPAMMPGQIPDPSVTTGSL-PGLGPLTGL------PSSALTVEELKYADIRN 10 20 30 40 50 60 70 80 90 100 110 pF1KB7 KHLCHRMSSALESVTVSDRPLGVSITKAEVAPEEDERKKRRRERNKIAAAKCRNKKKEKT :: : .. :: : :.:. ::.::.:::::.::.:::.:::::::.: XP_016 LGAMIAPLHFLE-VKLGKRPQPV---KSEL-DEEEERRKRRREKNKVAAARCRNKKKERT 60 70 80 90 100 120 130 140 150 160 170 pF1KB7 ECLQKESEKLESVNAELKAQIEELKNEKQHLIYMLNLHRPTCIVRAQNGRTPEDERNLFI : ::.:::.:: .:::::.::::::.:.:.:: ::: ::::::::... .:::.: : .. XP_016 EFLQRESERLELMNAELKTQIEELKQERQQLILMLNRHRPTCIVRTDSVKTPESEGNPLL 110 120 130 140 150 160 180 pF1KB7 QQIKEGTLQS .:... XP_016 EQLEKK 170 181 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 14:38:26 2016 done: Sat Nov 5 14:38:27 2016 Total Scan time: 6.430 Total Display time: -0.030 Function used was FASTA [36.3.4 Apr, 2011]