FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB7926, 350 aa 1>>>pF1KB7926 350 - 350 aa - 350 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 9.7567+/-0.000321; mu= -0.2823+/- 0.020 mean_var=299.3390+/-60.365, 0's: 0 Z-trim(125.3): 11 B-trim: 262 in 2/56 Lambda= 0.074130 statistics sampled from 48638 (48649) to 48638 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.836), E-opt: 0.2 (0.57), width: 16 Scan time: 10.320 The best scores are: opt bits E(85289) NP_001011663 (OMIM: 607816) polycomb group RING fi ( 350) 2353 264.1 3.3e-70 NP_115530 (OMIM: 607816) polycomb group RING finge ( 275) 1264 147.5 3.1e-35 NP_116062 (OMIM: 610231) polycomb group RING finge ( 259) 524 68.4 2e-11 NP_005171 (OMIM: 164831) polycomb complex protein ( 326) 482 64.0 5.3e-10 XP_005257698 (OMIM: 600346) PREDICTED: polycomb gr ( 344) 476 63.4 8.7e-10 NP_009075 (OMIM: 600346) polycomb group RING finge ( 344) 476 63.4 8.7e-10 XP_016880505 (OMIM: 600346) PREDICTED: polycomb gr ( 344) 476 63.4 8.7e-10 XP_005257697 (OMIM: 600346) PREDICTED: polycomb gr ( 344) 476 63.4 8.7e-10 XP_005257699 (OMIM: 600346) PREDICTED: polycomb gr ( 344) 476 63.4 8.7e-10 >>NP_001011663 (OMIM: 607816) polycomb group RING finger (350 aa) initn: 2353 init1: 2353 opt: 2353 Z-score: 1381.5 bits: 264.1 E(85289): 3.3e-70 Smith-Waterman score: 2353; 100.0% identity (100.0% similar) in 350 aa overlap (1-350:1-350) 10 20 30 40 50 60 pF1KB7 MEGVAVVTAGSVGAAKTEGAAALPPPPPVSPPALTPAPAAGEEGPAPLSETGAPGCSGSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MEGVAVVTAGSVGAAKTEGAAALPPPPPVSPPALTPAPAAGEEGPAPLSETGAPGCSGSR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 PPELEPERSLGRFRGRFEDEDEELEEEEELEEEEEEEEEDMSHFSLRLEGGRQDSEDEEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PPELEPERSLGRFRGRFEDEDEELEEEEELEEEEEEEEEDMSHFSLRLEGGRQDSEDEEE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 RLINLSELTPYILCSICKGYLIDATTITECLHTFCKSCIVRHFYYSNRCPKCNIVVHQTQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RLINLSELTPYILCSICKGYLIDATTITECLHTFCKSCIVRHFYYSNRCPKCNIVVHQTQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 PLYNIRLDRQLQDIVYKLVINLEEREKKQMHDFYKERGLEVPKPAVPQPVPSSKGRSKKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PLYNIRLDRQLQDIVYKLVINLEEREKKQMHDFYKERGLEVPKPAVPQPVPSSKGRSKKV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 LESVFRIPPELDMSLLLEFIGANEGTGHFKPLEKKFVRVSGEATIGHVEKFLRRKMGLDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LESVFRIPPELDMSLLLEFIGANEGTGHFKPLEKKFVRVSGEATIGHVEKFLRRKMGLDP 250 260 270 280 290 300 310 320 330 340 350 pF1KB7 ACQVDIICGDHLLEQYQTLREIRRAIGDAAMQDGLLVLHYGLVVSPLKIT :::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ACQVDIICGDHLLEQYQTLREIRRAIGDAAMQDGLLVLHYGLVVSPLKIT 310 320 330 340 350 >>NP_115530 (OMIM: 607816) polycomb group RING finger pr (275 aa) initn: 1264 init1: 1264 opt: 1264 Z-score: 753.4 bits: 147.5 E(85289): 3.1e-35 Smith-Waterman score: 1695; 78.3% identity (78.6% similar) in 350 aa overlap (1-350:1-275) 10 20 30 40 50 60 pF1KB7 MEGVAVVTAGSVGAAKTEGAAALPPPPPVSPPALTPAPAAGEEGPAPLSETGAPGCSGSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 MEGVAVVTAGSVGAAKTEGAAALPPPPPVSPPALTPAPAAGEEGPAPLSETGAPGCSGSR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 PPELEPERSLGRFRGRFEDEDEELEEEEELEEEEEEEEEDMSHFSLRLEGGRQDSEDEEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 PPELEPERSLGRFRGRFEDEDEELEEEEELEEEEEEEEEDMSHFSLRLEGGRQDSEDEEE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 RLINLSELTPYILCSICKGYLIDATTITECLHTFCKSCIVRHFYYSNRCPKCNIVVHQTQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 RLINLSELTPYILCSICKGYLIDATTITECLHTFCKSCIVRHFYYSNRCPKCNIVVHQTQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 PLYNIRLDRQLQDIVYKLVINLEEREKKQMHDFYKERGLEVPKPAVPQPVPSSKGRSKKV ::::: NP_115 PLYNI------------------------------------------------------- 250 260 270 280 290 300 pF1KB7 LESVFRIPPELDMSLLLEFIGANEGTGHFKPLEKKFVRVSGEATIGHVEKFLRRKMGLDP .::::::::::::::::::::::::::::::::::::::: NP_115 --------------------SANEGTGHFKPLEKKFVRVSGEATIGHVEKFLRRKMGLDP 190 200 210 220 310 320 330 340 350 pF1KB7 ACQVDIICGDHLLEQYQTLREIRRAIGDAAMQDGLLVLHYGLVVSPLKIT :::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 ACQVDIICGDHLLEQYQTLREIRRAIGDAAMQDGLLVLHYGLVVSPLKIT 230 240 250 260 270 >>NP_116062 (OMIM: 610231) polycomb group RING finger pr (259 aa) initn: 443 init1: 443 opt: 524 Z-score: 326.1 bits: 68.4 E(85289): 2e-11 Smith-Waterman score: 524; 38.9% identity (74.4% similar) in 211 aa overlap (117-322:30-236) 90 100 110 120 130 140 pF1KB7 EEELEEEEEEEEEDMSHFSLRLEGGRQDSEDEEERLINLSELTPYILCSICKGYLIDATT .::: .....:. .:.: .: ::..:::: NP_116 MASPQGGQIAIAMRLRNQLQSVYKMDPLRNEEEVRVKIKDLNEHIVCCLCAGYFVDATT 10 20 30 40 50 150 160 170 180 190 200 pF1KB7 ITECLHTFCKSCIVRHFYYSNRCPKCNIVVHQTQPLYNIRLDRQLQDIVYKLVINLEERE ::::::::::::::... :. :: ::: .:.:::: :..::: .:::::::: .:.. : NP_116 ITECLHTFCKSCIVKYLQTSKYCPMCNIKIHETQPLLNLKLDRVMQDIVYKLVPGLQDSE 60 70 80 90 100 110 210 220 230 240 250 260 pF1KB7 KKQMHDFYKERGLE-VPKPAVPQPVPSSKGRSKKVLES----VFRIPPELDMSLLLEFIG .:....::. :::. : .:. .:. :. : . .. .: .:. : :: .. NP_116 EKRIREFYQSRGLDRVTQPTGEEPALSNLGLPFSSFDHSKAHYYRYDEQLN--LCLERLS 120 130 140 150 160 170 270 280 290 300 310 320 pF1KB7 ANEGTGHFKPLEKKFVRVSGEATIGHVEKFLRRKMGLDPACQVDIICGDHLLEQYQTLRE ... .. . :..:.:: : .: . :... : ... :.: .:... ...: ...:... NP_116 SGKDKNK-SVLQNKYVRCSVRAEVRHLRRVLCHRLMLNPQ-HVQLLFDNEVLPDHMTMKQ 180 190 200 210 220 230 330 340 350 pF1KB7 IRRAIGDAAMQDGLLVLHYGLVVSPLKIT : NP_116 IWLSRWFGKPSPLLLQYSVKEKRR 240 250 >>NP_005171 (OMIM: 164831) polycomb complex protein BMI- (326 aa) initn: 494 init1: 393 opt: 482 Z-score: 300.5 bits: 64.0 E(85289): 5.3e-10 Smith-Waterman score: 482; 39.2% identity (66.5% similar) in 209 aa overlap (123-322:7-209) 100 110 120 130 140 150 pF1KB7 EEEEEEEDMSHFSLRLEGGRQDSEDEEERLINLSELTPYILCSICKGYLIDATTITECLH :...::.:...: .: ::.:::::: :::: NP_005 MHRTTRIKITELNPHLMCVLCGGYFIDATTIIECLH 10 20 30 160 170 180 190 200 210 pF1KB7 TFCKSCIVRHFYYSNRCPKCNIVVHQTQPLYNIRLDRQLQDIVYKLVINLEEREKKQMHD .:::.::::.. :. :: :.. ::.:.:: ::: :. ::::::::: .: . : :. .: NP_005 SFCKTCIVRYLETSKYCPICDVQVHKTRPLLNIRSDKTLQDIVYKLVPGLFKNEMKRRRD 40 50 60 70 80 90 220 230 240 250 260 pF1KB7 FYKERGLEVPKPAVPQPVPSSKGRSKKVLESVFRIPPELDMSLLLEFIGANE-----GTG :: . .:.. :.. :.. . :. : . .:: .::. :. . NP_005 FY------AAHPSADAANGSNEDRGEVADEDKRIITDDEIISLSIEFFDQNRLDRKVNKD 100 110 120 130 140 150 270 280 290 300 310 320 pF1KB7 HFKPLE----KKFVRVSGEATIGHVEKFLRRKMGLDPACQVDIICGDHLLEQYQTLREIR . : : :...: . :. :..:::: :: . . :.:.. .. :..: :: .: NP_005 KEKSKEEVNDKRYLRCPAAMTVMHLRKFLRSKMDIPNTFQIDVMYEEEPLKDYYTLMDIA 160 170 180 190 200 210 330 340 350 pF1KB7 RAIGDAAMQDGLLVLHYGLVVSPLKIT NP_005 YIYTWRRNGPLPLKYRVRPTCKRMKISHQRDGLTNAGELESDSGSDKANSPAGGIPSTSS 220 230 240 250 260 270 >>XP_005257698 (OMIM: 600346) PREDICTED: polycomb group (344 aa) initn: 448 init1: 387 opt: 476 Z-score: 296.7 bits: 63.4 E(85289): 8.7e-10 Smith-Waterman score: 476; 38.4% identity (64.9% similar) in 211 aa overlap (123-322:7-211) 100 110 120 130 140 150 pF1KB7 EEEEEEEDMSHFSLRLEGGRQDSEDEEERLINLSELTPYILCSICKGYLIDATTITECLH :...::.:...:..: ::.::::::.:::: XP_005 MHRTTRIKITELNPHLMCALCGGYFIDATTIVECLH 10 20 30 160 170 180 190 200 210 pF1KB7 TFCKSCIVRHFYYSNRCPKCNIVVHQTQPLYNIRLDRQLQDIVYKLVINLEEREKKQMHD .:::.::::.. .. :: :.. ::.:.:: .:: :. ::::::::: .: . : :. .: XP_005 SFCKTCIVRYLETNKYCPMCDVQVHKTRPLLSIRSDKTLQDIVYKLVPGLFKDEMKRRRD 40 50 60 70 80 90 220 230 240 250 260 270 pF1KB7 FYKERGLEVPKPAVPQPVPSSKGRSKKVLESVFRIPPELDMSLLLEFI-GANEGTGHFKP :: . : . : :.. :.. . . . . .:: .:: :: . . : XP_005 FY------AAYPLTEVPNGSNEDRGEVLEQEKGALSDDEIVSLSIEFYEGARDRDEKKGP 100 110 120 130 140 150 280 290 300 310 320 pF1KB7 LEK----------KFVRVSGEATIGHVEKFLRRKMGLDPACQVDIICGDHLLEQYQTLRE ::. .:.: . :. :. :::: :: . .:... :. :..: :: . XP_005 LENGDGDKEKTGVRFLRCPAAMTVMHLAKFLRNKMDVPSKYKVEVLYEDEPLKEYYTLMD 160 170 180 190 200 210 330 340 350 pF1KB7 IRRAIGDAAMQDGLLVLHYGLVVSPLKIT : XP_005 IAYIYPWRRNGPLPLKYRVQPACKRLTLATVPTPSEGTNTSGASECESVSDKAPSPATLP 220 230 240 250 260 270 >>NP_009075 (OMIM: 600346) polycomb group RING finger pr (344 aa) initn: 448 init1: 387 opt: 476 Z-score: 296.7 bits: 63.4 E(85289): 8.7e-10 Smith-Waterman score: 476; 38.4% identity (64.9% similar) in 211 aa overlap (123-322:7-211) 100 110 120 130 140 150 pF1KB7 EEEEEEEDMSHFSLRLEGGRQDSEDEEERLINLSELTPYILCSICKGYLIDATTITECLH :...::.:...:..: ::.::::::.:::: NP_009 MHRTTRIKITELNPHLMCALCGGYFIDATTIVECLH 10 20 30 160 170 180 190 200 210 pF1KB7 TFCKSCIVRHFYYSNRCPKCNIVVHQTQPLYNIRLDRQLQDIVYKLVINLEEREKKQMHD .:::.::::.. .. :: :.. ::.:.:: .:: :. ::::::::: .: . : :. .: NP_009 SFCKTCIVRYLETNKYCPMCDVQVHKTRPLLSIRSDKTLQDIVYKLVPGLFKDEMKRRRD 40 50 60 70 80 90 220 230 240 250 260 270 pF1KB7 FYKERGLEVPKPAVPQPVPSSKGRSKKVLESVFRIPPELDMSLLLEFI-GANEGTGHFKP :: . : . : :.. :.. . . . . .:: .:: :: . . : NP_009 FY------AAYPLTEVPNGSNEDRGEVLEQEKGALSDDEIVSLSIEFYEGARDRDEKKGP 100 110 120 130 140 150 280 290 300 310 320 pF1KB7 LEK----------KFVRVSGEATIGHVEKFLRRKMGLDPACQVDIICGDHLLEQYQTLRE ::. .:.: . :. :. :::: :: . .:... :. :..: :: . NP_009 LENGDGDKEKTGVRFLRCPAAMTVMHLAKFLRNKMDVPSKYKVEVLYEDEPLKEYYTLMD 160 170 180 190 200 210 330 340 350 pF1KB7 IRRAIGDAAMQDGLLVLHYGLVVSPLKIT : NP_009 IAYIYPWRRNGPLPLKYRVQPACKRLTLATVPTPSEGTNTSGASECESVSDKAPSPATLP 220 230 240 250 260 270 >>XP_016880505 (OMIM: 600346) PREDICTED: polycomb group (344 aa) initn: 448 init1: 387 opt: 476 Z-score: 296.7 bits: 63.4 E(85289): 8.7e-10 Smith-Waterman score: 476; 38.4% identity (64.9% similar) in 211 aa overlap (123-322:7-211) 100 110 120 130 140 150 pF1KB7 EEEEEEEDMSHFSLRLEGGRQDSEDEEERLINLSELTPYILCSICKGYLIDATTITECLH :...::.:...:..: ::.::::::.:::: XP_016 MHRTTRIKITELNPHLMCALCGGYFIDATTIVECLH 10 20 30 160 170 180 190 200 210 pF1KB7 TFCKSCIVRHFYYSNRCPKCNIVVHQTQPLYNIRLDRQLQDIVYKLVINLEEREKKQMHD .:::.::::.. .. :: :.. ::.:.:: .:: :. ::::::::: .: . : :. .: XP_016 SFCKTCIVRYLETNKYCPMCDVQVHKTRPLLSIRSDKTLQDIVYKLVPGLFKDEMKRRRD 40 50 60 70 80 90 220 230 240 250 260 270 pF1KB7 FYKERGLEVPKPAVPQPVPSSKGRSKKVLESVFRIPPELDMSLLLEFI-GANEGTGHFKP :: . : . : :.. :.. . . . . .:: .:: :: . . : XP_016 FY------AAYPLTEVPNGSNEDRGEVLEQEKGALSDDEIVSLSIEFYEGARDRDEKKGP 100 110 120 130 140 150 280 290 300 310 320 pF1KB7 LEK----------KFVRVSGEATIGHVEKFLRRKMGLDPACQVDIICGDHLLEQYQTLRE ::. .:.: . :. :. :::: :: . .:... :. :..: :: . XP_016 LENGDGDKEKTGVRFLRCPAAMTVMHLAKFLRNKMDVPSKYKVEVLYEDEPLKEYYTLMD 160 170 180 190 200 210 330 340 350 pF1KB7 IRRAIGDAAMQDGLLVLHYGLVVSPLKIT : XP_016 IAYIYPWRRNGPLPLKYRVQPACKRLTLATVPTPSEGTNTSGASECESVSDKAPSPATLP 220 230 240 250 260 270 >>XP_005257697 (OMIM: 600346) PREDICTED: polycomb group (344 aa) initn: 448 init1: 387 opt: 476 Z-score: 296.7 bits: 63.4 E(85289): 8.7e-10 Smith-Waterman score: 476; 38.4% identity (64.9% similar) in 211 aa overlap (123-322:7-211) 100 110 120 130 140 150 pF1KB7 EEEEEEEDMSHFSLRLEGGRQDSEDEEERLINLSELTPYILCSICKGYLIDATTITECLH :...::.:...:..: ::.::::::.:::: XP_005 MHRTTRIKITELNPHLMCALCGGYFIDATTIVECLH 10 20 30 160 170 180 190 200 210 pF1KB7 TFCKSCIVRHFYYSNRCPKCNIVVHQTQPLYNIRLDRQLQDIVYKLVINLEEREKKQMHD .:::.::::.. .. :: :.. ::.:.:: .:: :. ::::::::: .: . : :. .: XP_005 SFCKTCIVRYLETNKYCPMCDVQVHKTRPLLSIRSDKTLQDIVYKLVPGLFKDEMKRRRD 40 50 60 70 80 90 220 230 240 250 260 270 pF1KB7 FYKERGLEVPKPAVPQPVPSSKGRSKKVLESVFRIPPELDMSLLLEFI-GANEGTGHFKP :: . : . : :.. :.. . . . . .:: .:: :: . . : XP_005 FY------AAYPLTEVPNGSNEDRGEVLEQEKGALSDDEIVSLSIEFYEGARDRDEKKGP 100 110 120 130 140 150 280 290 300 310 320 pF1KB7 LEK----------KFVRVSGEATIGHVEKFLRRKMGLDPACQVDIICGDHLLEQYQTLRE ::. .:.: . :. :. :::: :: . .:... :. :..: :: . XP_005 LENGDGDKEKTGVRFLRCPAAMTVMHLAKFLRNKMDVPSKYKVEVLYEDEPLKEYYTLMD 160 170 180 190 200 210 330 340 350 pF1KB7 IRRAIGDAAMQDGLLVLHYGLVVSPLKIT : XP_005 IAYIYPWRRNGPLPLKYRVQPACKRLTLATVPTPSEGTNTSGASECESVSDKAPSPATLP 220 230 240 250 260 270 >>XP_005257699 (OMIM: 600346) PREDICTED: polycomb group (344 aa) initn: 448 init1: 387 opt: 476 Z-score: 296.7 bits: 63.4 E(85289): 8.7e-10 Smith-Waterman score: 476; 38.4% identity (64.9% similar) in 211 aa overlap (123-322:7-211) 100 110 120 130 140 150 pF1KB7 EEEEEEEDMSHFSLRLEGGRQDSEDEEERLINLSELTPYILCSICKGYLIDATTITECLH :...::.:...:..: ::.::::::.:::: XP_005 MHRTTRIKITELNPHLMCALCGGYFIDATTIVECLH 10 20 30 160 170 180 190 200 210 pF1KB7 TFCKSCIVRHFYYSNRCPKCNIVVHQTQPLYNIRLDRQLQDIVYKLVINLEEREKKQMHD .:::.::::.. .. :: :.. ::.:.:: .:: :. ::::::::: .: . : :. .: XP_005 SFCKTCIVRYLETNKYCPMCDVQVHKTRPLLSIRSDKTLQDIVYKLVPGLFKDEMKRRRD 40 50 60 70 80 90 220 230 240 250 260 270 pF1KB7 FYKERGLEVPKPAVPQPVPSSKGRSKKVLESVFRIPPELDMSLLLEFI-GANEGTGHFKP :: . : . : :.. :.. . . . . .:: .:: :: . . : XP_005 FY------AAYPLTEVPNGSNEDRGEVLEQEKGALSDDEIVSLSIEFYEGARDRDEKKGP 100 110 120 130 140 150 280 290 300 310 320 pF1KB7 LEK----------KFVRVSGEATIGHVEKFLRRKMGLDPACQVDIICGDHLLEQYQTLRE ::. .:.: . :. :. :::: :: . .:... :. :..: :: . XP_005 LENGDGDKEKTGVRFLRCPAAMTVMHLAKFLRNKMDVPSKYKVEVLYEDEPLKEYYTLMD 160 170 180 190 200 210 330 340 350 pF1KB7 IRRAIGDAAMQDGLLVLHYGLVVSPLKIT : XP_005 IAYIYPWRRNGPLPLKYRVQPACKRLTLATVPTPSEGTNTSGASECESVSDKAPSPATLP 220 230 240 250 260 270 350 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 19:49:18 2016 done: Sat Nov 5 19:49:19 2016 Total Scan time: 10.320 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]