FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB7927, 200 aa 1>>>pF1KB7927 200 - 200 aa - 200 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.8578+/-0.000312; mu= 16.5197+/- 0.020 mean_var=67.4803+/-13.548, 0's: 0 Z-trim(116.6): 136 B-trim: 0 in 0/53 Lambda= 0.156130 statistics sampled from 27738 (27876) to 27738 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.707), E-opt: 0.2 (0.327), width: 16 Scan time: 6.190 The best scores are: opt bits E(85289) NP_005330 (OMIM: 602846) ubiquitin-conjugating enz ( 200) 1310 303.3 1.7e-82 NP_001104582 (OMIM: 602846) ubiquitin-conjugating ( 157) 873 204.8 6.1e-53 NP_001104583 (OMIM: 602846) ubiquitin-conjugating ( 149) 836 196.4 1.9e-50 NP_001299576 (OMIM: 602846) ubiquitin-conjugating ( 97) 622 148.1 4.4e-36 NP_001299577 (OMIM: 602846) ubiquitin-conjugating ( 97) 622 148.1 4.4e-36 NP_001299575 (OMIM: 602846) ubiquitin-conjugating ( 139) 477 115.5 3.9e-26 NP_003339 (OMIM: 603679) ubiquitin-conjugating enz ( 152) 444 108.1 7.3e-24 NP_003329 (OMIM: 602961) ubiquitin-conjugating enz ( 147) 405 99.3 3.1e-21 NP_003330 (OMIM: 602962) ubiquitin-conjugating enz ( 147) 405 99.3 3.1e-21 NP_871621 (OMIM: 602963) ubiquitin-conjugating enz ( 148) 400 98.2 6.9e-21 NP_003331 (OMIM: 602963) ubiquitin-conjugating enz ( 147) 397 97.5 1.1e-20 NP_871615 (OMIM: 602963) ubiquitin-conjugating enz ( 147) 397 97.5 1.1e-20 NP_871619 (OMIM: 602963) ubiquitin-conjugating enz ( 147) 397 97.5 1.1e-20 NP_871618 (OMIM: 602963) ubiquitin-conjugating enz ( 147) 397 97.5 1.1e-20 NP_871617 (OMIM: 602963) ubiquitin-conjugating enz ( 147) 397 97.5 1.1e-20 NP_871616 (OMIM: 602963) ubiquitin-conjugating enz ( 147) 397 97.5 1.1e-20 NP_871620 (OMIM: 602963) ubiquitin-conjugating enz ( 147) 397 97.5 1.1e-20 XP_016865309 (OMIM: 602962) PREDICTED: ubiquitin-c ( 173) 387 95.3 5.9e-20 NP_862821 (OMIM: 602962) ubiquitin-conjugating enz ( 118) 383 94.3 8.2e-20 XP_016872098 (OMIM: 602961) PREDICTED: ubiquitin-c ( 110) 382 94.1 9.1e-20 NP_871622 (OMIM: 602963) ubiquitin-conjugating enz ( 149) 380 93.7 1.6e-19 NP_054895 (OMIM: 610538,616435) ubiquitin-conjugat ( 197) 381 94.0 1.7e-19 NP_001287724 (OMIM: 602963) ubiquitin-conjugating ( 118) 375 92.5 2.9e-19 XP_016864073 (OMIM: 602963) PREDICTED: ubiquitin-c ( 118) 375 92.5 2.9e-19 NP_001191809 (OMIM: 602961) ubiquitin-conjugating ( 109) 364 90.0 1.5e-18 NP_689866 (OMIM: 602163) ubiquitin-conjugating enz ( 201) 366 90.7 1.8e-18 XP_005265489 (OMIM: 602163) PREDICTED: ubiquitin-c ( 201) 366 90.7 1.8e-18 NP_001297255 (OMIM: 610538,616435) ubiquitin-conju ( 167) 364 90.1 2.1e-18 XP_005246301 (OMIM: 604151) PREDICTED: ubiquitin-c ( 207) 365 90.4 2.1e-18 NP_001265484 (OMIM: 604151) ubiquitin-conjugating ( 207) 365 90.4 2.1e-18 NP_001265483 (OMIM: 604151) ubiquitin-conjugating ( 207) 365 90.4 2.1e-18 NP_872619 (OMIM: 604151) ubiquitin-conjugating enz ( 207) 365 90.4 2.1e-18 NP_006348 (OMIM: 604151) ubiquitin-conjugating enz ( 207) 365 90.4 2.1e-18 NP_003332 (OMIM: 602916) ubiquitin-conjugating enz ( 193) 363 90.0 2.7e-18 NP_001189405 (OMIM: 602916) ubiquitin-conjugating ( 160) 359 89.0 4.4e-18 NP_872607 (OMIM: 602916) ubiquitin-conjugating enz ( 176) 358 88.8 5.5e-18 NP_055316 (OMIM: 610309) ubiquitin-conjugating enz ( 222) 320 80.3 2.5e-15 NP_003327 (OMIM: 300860,312180) ubiquitin-conjugat ( 152) 317 79.5 3e-15 NP_003328 (OMIM: 179095) ubiquitin-conjugating enz ( 152) 316 79.3 3.5e-15 NP_003335 (OMIM: 601082) ubiquitin-conjugating enz ( 183) 315 79.1 4.7e-15 XP_005265490 (OMIM: 602163) PREDICTED: ubiquitin-c ( 189) 314 78.9 5.6e-15 NP_008950 (OMIM: 605574) ubiquitin-conjugating enz ( 179) 309 77.8 1.2e-14 NP_861517 (OMIM: 605574) ubiquitin-conjugating enz ( 140) 307 77.2 1.3e-14 NP_001269090 (OMIM: 300860,312180) ubiquitin-conju ( 119) 301 75.8 3e-14 NP_003338 (OMIM: 603721) ubiquitin-conjugating enz ( 154) 296 74.8 8e-14 XP_005265488 (OMIM: 602916) PREDICTED: ubiquitin-c ( 167) 296 74.8 8.5e-14 NP_861516 (OMIM: 605574) ubiquitin-conjugating enz ( 150) 286 72.5 3.7e-13 NP_001243284 (OMIM: 603721) ubiquitin-conjugating ( 212) 282 71.8 9.1e-13 XP_016879129 (OMIM: 601661) PREDICTED: SUMO-conjug ( 158) 264 67.6 1.2e-11 NP_003336 (OMIM: 601661) SUMO-conjugating enzyme U ( 158) 264 67.6 1.2e-11 >>NP_005330 (OMIM: 602846) ubiquitin-conjugating enzyme (200 aa) initn: 1310 init1: 1310 opt: 1310 Z-score: 1602.0 bits: 303.3 E(85289): 1.7e-82 Smith-Waterman score: 1310; 100.0% identity (100.0% similar) in 200 aa overlap (1-200:1-200) 10 20 30 40 50 60 pF1KB7 MANIAVQRIKREFKEVLKSEETSKNQIKVDLVDENFTELRGEIAGPPDTPYEGGRYQLEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MANIAVQRIKREFKEVLKSEETSKNQIKVDLVDENFTELRGEIAGPPDTPYEGGRYQLEI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 KIPETYPFNPPKVRFITKIWHPNISSVTGAICLDILKDQWAAAMTLRTVLLSLQALLAAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 KIPETYPFNPPKVRFITKIWHPNISSVTGAICLDILKDQWAAAMTLRTVLLSLQALLAAA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 EPDDPQDAVVANQYKQNPEMFKQTARLWAHVYAGAPVSSPEYTKKIENLCAMGFDRNAVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 EPDDPQDAVVANQYKQNPEMFKQTARLWAHVYAGAPVSSPEYTKKIENLCAMGFDRNAVI 130 140 150 160 170 180 190 200 pF1KB7 VALSSKSWDVETATELLLSN :::::::::::::::::::: NP_005 VALSSKSWDVETATELLLSN 190 200 >>NP_001104582 (OMIM: 602846) ubiquitin-conjugating enzy (157 aa) initn: 870 init1: 870 opt: 873 Z-score: 1071.4 bits: 204.8 E(85289): 6.1e-53 Smith-Waterman score: 914; 78.5% identity (78.5% similar) in 200 aa overlap (1-200:1-157) 10 20 30 40 50 60 pF1KB7 MANIAVQRIKREFKEVLKSEETSKNQIKVDLVDENFTELRGEIAGPPDTPYEGGRYQLEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MANIAVQRIKREFKEVLKSEETSKNQIKVDLVDENFTELRGEIAGPPDTPYEGGRYQLEI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 KIPETYPFNPPKVRFITKIWHPNISSVTGAICLDILKDQWAAAMTLRTVLLSLQALLAAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KIPETYPFNPPKVRFITKIWHPNISSVTGAICLDILKDQWAAAMTLRTVLLSLQALLAAA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 EPDDPQDAVVANQYKQNPEMFKQTARLWAHVYAGAPVSSPEYTKKIENLCAMGFDRNAVI ::::::::::::: :::: NP_001 EPDDPQDAVVANQ-------------------------------------------NAVI 130 190 200 pF1KB7 VALSSKSWDVETATELLLSN :::::::::::::::::::: NP_001 VALSSKSWDVETATELLLSN 140 150 >>NP_001104583 (OMIM: 602846) ubiquitin-conjugating enzy (149 aa) initn: 836 init1: 836 opt: 836 Z-score: 1026.7 bits: 196.4 E(85289): 1.9e-50 Smith-Waterman score: 848; 74.5% identity (74.5% similar) in 200 aa overlap (1-200:1-149) 10 20 30 40 50 60 pF1KB7 MANIAVQRIKREFKEVLKSEETSKNQIKVDLVDENFTELRGEIAGPPDTPYEGGRYQLEI ::::::::::::::::::::: NP_001 MANIAVQRIKREFKEVLKSEE--------------------------------------- 10 20 70 80 90 100 110 120 pF1KB7 KIPETYPFNPPKVRFITKIWHPNISSVTGAICLDILKDQWAAAMTLRTVLLSLQALLAAA :::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ------------VRFITKIWHPNISSVTGAICLDILKDQWAAAMTLRTVLLSLQALLAAA 30 40 50 60 130 140 150 160 170 180 pF1KB7 EPDDPQDAVVANQYKQNPEMFKQTARLWAHVYAGAPVSSPEYTKKIENLCAMGFDRNAVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EPDDPQDAVVANQYKQNPEMFKQTARLWAHVYAGAPVSSPEYTKKIENLCAMGFDRNAVI 70 80 90 100 110 120 190 200 pF1KB7 VALSSKSWDVETATELLLSN :::::::::::::::::::: NP_001 VALSSKSWDVETATELLLSN 130 140 >>NP_001299576 (OMIM: 602846) ubiquitin-conjugating enzy (97 aa) initn: 622 init1: 622 opt: 622 Z-score: 768.7 bits: 148.1 E(85289): 4.4e-36 Smith-Waterman score: 622; 100.0% identity (100.0% similar) in 97 aa overlap (104-200:1-97) 80 90 100 110 120 130 pF1KB7 RFITKIWHPNISSVTGAICLDILKDQWAAAMTLRTVLLSLQALLAAAEPDDPQDAVVANQ :::::::::::::::::::::::::::::: NP_001 MTLRTVLLSLQALLAAAEPDDPQDAVVANQ 10 20 30 140 150 160 170 180 190 pF1KB7 YKQNPEMFKQTARLWAHVYAGAPVSSPEYTKKIENLCAMGFDRNAVIVALSSKSWDVETA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YKQNPEMFKQTARLWAHVYAGAPVSSPEYTKKIENLCAMGFDRNAVIVALSSKSWDVETA 40 50 60 70 80 90 200 pF1KB7 TELLLSN ::::::: NP_001 TELLLSN >>NP_001299577 (OMIM: 602846) ubiquitin-conjugating enzy (97 aa) initn: 622 init1: 622 opt: 622 Z-score: 768.7 bits: 148.1 E(85289): 4.4e-36 Smith-Waterman score: 622; 100.0% identity (100.0% similar) in 97 aa overlap (104-200:1-97) 80 90 100 110 120 130 pF1KB7 RFITKIWHPNISSVTGAICLDILKDQWAAAMTLRTVLLSLQALLAAAEPDDPQDAVVANQ :::::::::::::::::::::::::::::: NP_001 MTLRTVLLSLQALLAAAEPDDPQDAVVANQ 10 20 30 140 150 160 170 180 190 pF1KB7 YKQNPEMFKQTARLWAHVYAGAPVSSPEYTKKIENLCAMGFDRNAVIVALSSKSWDVETA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YKQNPEMFKQTARLWAHVYAGAPVSSPEYTKKIENLCAMGFDRNAVIVALSSKSWDVETA 40 50 60 70 80 90 200 pF1KB7 TELLLSN ::::::: NP_001 TELLLSN >>NP_001299575 (OMIM: 602846) ubiquitin-conjugating enzy (139 aa) initn: 497 init1: 477 opt: 477 Z-score: 590.1 bits: 115.5 E(85289): 3.9e-26 Smith-Waterman score: 783; 69.5% identity (69.5% similar) in 200 aa overlap (1-200:1-139) 10 20 30 40 50 60 pF1KB7 MANIAVQRIKREFKEVLKSEETSKNQIKVDLVDENFTELRGEIAGPPDTPYEGGRYQLEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MANIAVQRIKREFKEVLKSEETSKNQIKVDLVDENFTELRGEIAGPPDTPYEGGRYQLEI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 KIPETYPFNPPKVRFITKIWHPNISSVTGAICLDILKDQWAAAMTLRTVLLSLQALLAAA :::::::::::: NP_001 KIPETYPFNPPK------------------------------------------------ 70 130 140 150 160 170 180 pF1KB7 EPDDPQDAVVANQYKQNPEMFKQTARLWAHVYAGAPVSSPEYTKKIENLCAMGFDRNAVI ::::::::::::::::::::::::::::::::::::::::::::::: NP_001 -------------YKQNPEMFKQTARLWAHVYAGAPVSSPEYTKKIENLCAMGFDRNAVI 80 90 100 110 190 200 pF1KB7 VALSSKSWDVETATELLLSN :::::::::::::::::::: NP_001 VALSSKSWDVETATELLLSN 120 130 >>NP_003339 (OMIM: 603679) ubiquitin-conjugating enzyme (152 aa) initn: 439 init1: 244 opt: 444 Z-score: 549.4 bits: 108.1 E(85289): 7.3e-24 Smith-Waterman score: 444; 47.9% identity (72.9% similar) in 144 aa overlap (10-153:6-148) 10 20 30 40 50 60 pF1KB7 MANIAVQRIKREFKEVLKSEETSKNQIKVDLVDENFTELRGEIAGPPDTPYEGGRYQLEI .: .::. . ::.. . : .. :::: :.:.::: ..::. NP_003 MAGLPRRIIKETQRLLAEPVPGIKAEPDESNARYFHVVIAGPQDSPFEGGTFKLEL 10 20 30 40 50 70 80 90 100 110 120 pF1KB7 KIPETYPFNPPKVRFITKIWHPNISSVTGAICLDILKDQWAAAMTLRTVLLSLQALLAAA .:: ::. :::::.:::.:::.... : ::::::::.:. :. .::::::.::::.: NP_003 FLPEEYPMAAPKVRFMTKIYHPNVDKL-GRICLDILKDKWSPALQIRTVLLSIQALLSAP 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB7 EPDDPQDAVVANQYKQNPEMFKQTARLWAHVYAGAPVSSPEYTKKIENLCAMGFDRNAVI .:::: ::.:.: : . .::: :...:: NP_003 NPDDPLANDVAEQWKTNEAQAIETARAWTRLYAMNNI 120 130 140 150 190 200 pF1KB7 VALSSKSWDVETATELLLSN >>NP_003329 (OMIM: 602961) ubiquitin-conjugating enzyme (147 aa) initn: 392 init1: 205 opt: 405 Z-score: 502.1 bits: 99.3 E(85289): 3.1e-21 Smith-Waterman score: 405; 40.0% identity (73.3% similar) in 150 aa overlap (4-153:1-146) 10 20 30 40 50 60 pF1KB7 MANIAVQRIKREFKEVLKSEETSKNQIKVDLVDENFTELRGEIAGPPDTPYEGGRYQLEI .:..::..:.... .. . . .. : ... . .. : ::::. :.:: . : . NP_003 MALKRIQKELSDLQRDPPA---HCSAGPVGDDLFHWQATIMGPPDSAYQGGVFFLTV 10 20 30 40 50 70 80 90 100 110 120 pF1KB7 KIPETYPFNPPKVRFITKIWHPNISSVTGAICLDILKDQWAAAMTLRTVLLSLQALLAAA ..: :::.:::. : :::.::::.: .:.::::::..::. :.:. ::::. .:: NP_003 HFPTDYPFKPPKIAFTTKIYHPNINS-NGSICLDILRSQWSPALTVSKVLLSICSLLCDP 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB7 EPDDPQDAVVANQYKQNPEMFKQTARLWAHVYAGAPVSSPEYTKKIENLCAMGFDRNAVI .:::: .:. ::.. : ... :: :.. :: NP_003 NPDDPLVPDIAQIYKSDKEKYNRHAREWTQKYAM 120 130 140 190 200 pF1KB7 VALSSKSWDVETATELLLSN >>NP_003330 (OMIM: 602962) ubiquitin-conjugating enzyme (147 aa) initn: 393 init1: 207 opt: 405 Z-score: 502.1 bits: 99.3 E(85289): 3.1e-21 Smith-Waterman score: 405; 41.3% identity (72.0% similar) in 150 aa overlap (4-153:1-146) 10 20 30 40 50 60 pF1KB7 MANIAVQRIKREFKEVLKSEETSKNQIKVDLVDENFTELRGEIAGPPDTPYEGGRYQLEI .:..::..:.... .. . : .. : ... . .. : :: :.::.:: . : : NP_003 MALKRIHKELNDLARDPPA---QCSAGPVGDDMFHWQATIMGPNDSPYQGGVFFLTI 10 20 30 40 50 70 80 90 100 110 120 pF1KB7 KIPETYPFNPPKVRFITKIWHPNISSVTGAICLDILKDQWAAAMTLRTVLLSLQALLAAA ..: :::.:::: : :.:.::::.: .:.::::::..::. :.:. ::::. .:: NP_003 HFPTDYPFKPPKVAFTTRIYHPNINS-NGSICLDILRSQWSPALTISKVLLSICSLLCDP 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB7 EPDDPQDAVVANQYKQNPEMFKQTARLWAHVYAGAPVSSPEYTKKIENLCAMGFDRNAVI .:::: .: :: . : ... :: :.. :: NP_003 NPDDPLVPEIARIYKTDREKYNRIAREWTQKYAM 120 130 140 190 200 pF1KB7 VALSSKSWDVETATELLLSN >>NP_871621 (OMIM: 602963) ubiquitin-conjugating enzyme (148 aa) initn: 386 init1: 205 opt: 400 Z-score: 496.0 bits: 98.2 E(85289): 6.9e-21 Smith-Waterman score: 400; 40.7% identity (72.0% similar) in 150 aa overlap (4-153:1-146) 10 20 30 40 50 60 pF1KB7 MANIAVQRIKREFKEVLKSEETSKNQIKVDLVDENFTELRGEIAGPPDTPYEGGRYQLEI .:..::..:.... .. . : .. : ... . .. : :: :.::.:: . : : NP_871 MALKRINKELSDLARDPPA---QCSAGPVGDDMFHWQATIMGPNDSPYQGGVFFLTI 10 20 30 40 50 70 80 90 100 110 120 pF1KB7 KIPETYPFNPPKVRFITKIWHPNISSVTGAICLDILKDQWAAAMTLRTVLLSLQALLAAA ..: :::.:::: : :.:.::::.: .:.::::::..::. :.:. ::::. .:: NP_871 HFPTDYPFKPPKVAFTTRIYHPNINS-NGSICLDILRSQWSPALTISKVLLSICSLLCDP 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB7 EPDDPQDAVVANQYKQNPEMFKQTARLWAHVYAGAPVSSPEYTKKIENLCAMGFDRNAVI .:::: .: :: . . ... :: :.. :: NP_871 NPDDPLVPEIARIYKTDRDKYNRLAREWTEKYAML 120 130 140 190 200 pF1KB7 VALSSKSWDVETATELLLSN 200 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 14:39:04 2016 done: Sat Nov 5 14:39:05 2016 Total Scan time: 6.190 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]