FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB7943, 377 aa 1>>>pF1KB7943 377 - 377 aa - 377 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.1242+/-0.00036; mu= 7.9764+/- 0.023 mean_var=269.6296+/-54.409, 0's: 0 Z-trim(123.2): 212 B-trim: 37 in 1/54 Lambda= 0.078107 statistics sampled from 42408 (42679) to 42408 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.804), E-opt: 0.2 (0.5), width: 16 Scan time: 10.780 The best scores are: opt bits E(85289) NP_757379 (OMIM: 607410) diencephalon/mesencephalo ( 377) 2509 295.3 1.5e-79 XP_011538970 (OMIM: 607410) PREDICTED: diencephalo ( 377) 2509 295.3 1.5e-79 XP_016855778 (OMIM: 607410) PREDICTED: diencephalo ( 377) 2509 295.3 1.5e-79 NP_671725 (OMIM: 607410) diencephalon/mesencephalo ( 382) 2489 293.1 7.2e-79 NP_000545 (OMIM: 120970,268000,602225,613829) cone ( 299) 358 52.8 1.2e-06 NP_005020 (OMIM: 107250,602669,610623) pituitary h ( 302) 338 50.6 5.7e-06 NP_005160 (OMIM: 602078,602753) paired mesoderm ho ( 284) 324 49.0 1.6e-05 NP_006483 (OMIM: 136760,606014) homeobox protein a ( 343) 323 49.0 2e-05 NP_878314 (OMIM: 142993,610092,610093) visual syst ( 361) 323 49.0 2.1e-05 NP_003915 (OMIM: 209880,603851,613013) paired meso ( 314) 319 48.5 2.6e-05 NP_852126 (OMIM: 122880,148820,193500,268220,60659 ( 403) 318 48.5 3.3e-05 NP_852125 (OMIM: 122880,148820,193500,268220,60659 ( 407) 318 48.5 3.3e-05 NP_001263380 (OMIM: 606701) dorsal root ganglia ho ( 263) 314 47.8 3.4e-05 NP_055377 (OMIM: 600036) homeobox protein OTX1 [Ho ( 354) 316 48.2 3.5e-05 NP_001186699 (OMIM: 600036) homeobox protein OTX1 ( 354) 316 48.2 3.5e-05 NP_852122 (OMIM: 122880,148820,193500,268220,60659 ( 479) 318 48.6 3.7e-05 NP_001120838 (OMIM: 122880,148820,193500,268220,60 ( 483) 318 48.6 3.7e-05 NP_852123 (OMIM: 122880,148820,193500,268220,60659 ( 484) 318 48.6 3.7e-05 NP_620689 (OMIM: 300004,300215,300382,300419,30835 ( 562) 319 48.8 3.7e-05 NP_852124 (OMIM: 122880,148820,193500,268220,60659 ( 505) 318 48.6 3.8e-05 NP_068745 (OMIM: 605420,609597,613451,615529) home ( 411) 314 48.0 4.5e-05 NP_001257452 (OMIM: 600037,610125,613986) homeobox ( 289) 311 47.5 4.6e-05 NP_001257453 (OMIM: 600037,610125,613986) homeobox ( 289) 311 47.5 4.6e-05 NP_758840 (OMIM: 600037,610125,613986) homeobox pr ( 289) 311 47.5 4.6e-05 XP_011537084 (OMIM: 601527,613456) PREDICTED: ALX ( 231) 304 46.6 6.9e-05 NP_055403 (OMIM: 122000,148300,605020,614195) visu ( 365) 307 47.2 7.3e-05 NP_008833 (OMIM: 167420,202650) paired mesoderm ho ( 217) 302 46.4 7.7e-05 XP_016870292 (OMIM: 604675) PREDICTED: paired meso ( 193) 300 46.1 8.4e-05 NP_008913 (OMIM: 601527,613456) ALX homeobox prote ( 326) 304 46.8 8.6e-05 NP_057391 (OMIM: 604675) paired mesoderm homeobox ( 253) 300 46.2 0.0001 NP_001191327 (OMIM: 137600,180500,180550,601542,60 ( 317) 300 46.3 0.00012 NP_001191326 (OMIM: 137600,180500,180550,601542,60 ( 317) 300 46.3 0.00012 NP_700475 (OMIM: 137600,180500,180550,601542,60422 ( 317) 300 46.3 0.00012 NP_039236 (OMIM: 167410,268220) paired box protein ( 518) 303 46.9 0.00012 XP_016883326 (OMIM: 122000,148300,605020,614195) P ( 280) 298 46.0 0.00012 NP_002575 (OMIM: 167410,268220) paired box protein ( 520) 303 46.9 0.00012 NP_001257454 (OMIM: 600037,610125,613986) homeobox ( 297) 298 46.1 0.00013 NP_068374 (OMIM: 600037,610125,613986) homeobox pr ( 297) 298 46.1 0.00013 NP_001243201 (OMIM: 122000,148300,605020,614195) v ( 301) 298 46.1 0.00013 XP_006711451 (OMIM: 167420,202650) PREDICTED: pair ( 198) 294 45.4 0.00014 NP_073207 (OMIM: 167420,202650) paired mesoderm ho ( 245) 294 45.5 0.00016 XP_011530329 (OMIM: 137600,180500,180550,601542,60 ( 271) 294 45.6 0.00017 NP_001191328 (OMIM: 137600,180500,180550,601542,60 ( 271) 294 45.6 0.00017 NP_700476 (OMIM: 137600,180500,180550,601542,60422 ( 271) 294 45.6 0.00017 NP_001128726 (OMIM: 167410,268220) paired box prot ( 505) 299 46.5 0.00017 NP_000316 (OMIM: 137600,180500,180550,601542,60422 ( 324) 294 45.7 0.00019 NP_038463 (OMIM: 601881,611038) retinal homeobox p ( 346) 293 45.6 0.00021 NP_001297090 (OMIM: 106210,120430,136520,148190,16 ( 286) 291 45.3 0.00022 NP_001297089 (OMIM: 106210,120430,136520,148190,16 ( 286) 291 45.3 0.00022 NP_002644 (OMIM: 119800,186550,602149) pituitary h ( 314) 290 45.2 0.00025 >>NP_757379 (OMIM: 607410) diencephalon/mesencephalon ho (377 aa) initn: 2509 init1: 2509 opt: 2509 Z-score: 1549.2 bits: 295.3 E(85289): 1.5e-79 Smith-Waterman score: 2509; 100.0% identity (100.0% similar) in 377 aa overlap (1-377:1-377) 10 20 30 40 50 60 pF1KB7 MQHYGVNGYSLHAMNSLSAMYNLHQQAAQQAQHAPDYRPSVHALTLAERLADIILEARYG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_757 MQHYGVNGYSLHAMNSLSAMYNLHQQAAQQAQHAPDYRPSVHALTLAERLADIILEARYG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 SQHRKQRRSRTAFTAQQLEALEKTFQKTHYPDVVMRERLAMCTNLPEARVQVWFKNRRAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_757 SQHRKQRRSRTAFTAQQLEALEKTFQKTHYPDVVMRERLAMCTNLPEARVQVWFKNRRAK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 FRKKQRSLQKEQLQKQKEAEGSHGEGKAEAPTPDTQLDTEQPPRLPGSDPPAELHLSLSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_757 FRKKQRSLQKEQLQKQKEAEGSHGEGKAEAPTPDTQLDTEQPPRLPGSDPPAELHLSLSE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 QSASESAPEDQPDREEDPRAGAEDPKAEKSPGADSKGLGCKRGSPKADSPGSLTITPVAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_757 QSASESAPEDQPDREEDPRAGAEDPKAEKSPGADSKGLGCKRGSPKADSPGSLTITPVAP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 GGGLLGPSHSYSSSPLSLFRLQEQFRQHMAATNNLVHYSSFEVGGPAPAAAAAAAAVPYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_757 GGGLLGPSHSYSSSPLSLFRLQEQFRQHMAATNNLVHYSSFEVGGPAPAAAAAAAAVPYL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB7 GVNMAPLGSLHCQSYYQSLSAAAAAHQGVWGSPLLPAPPAGLAPASATLNSKTTSIENLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_757 GVNMAPLGSLHCQSYYQSLSAAAAAHQGVWGSPLLPAPPAGLAPASATLNSKTTSIENLR 310 320 330 340 350 360 370 pF1KB7 LRAKQHAASLGLDTLPN ::::::::::::::::: NP_757 LRAKQHAASLGLDTLPN 370 >>XP_011538970 (OMIM: 607410) PREDICTED: diencephalon/me (377 aa) initn: 2509 init1: 2509 opt: 2509 Z-score: 1549.2 bits: 295.3 E(85289): 1.5e-79 Smith-Waterman score: 2509; 100.0% identity (100.0% similar) in 377 aa overlap (1-377:1-377) 10 20 30 40 50 60 pF1KB7 MQHYGVNGYSLHAMNSLSAMYNLHQQAAQQAQHAPDYRPSVHALTLAERLADIILEARYG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MQHYGVNGYSLHAMNSLSAMYNLHQQAAQQAQHAPDYRPSVHALTLAERLADIILEARYG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 SQHRKQRRSRTAFTAQQLEALEKTFQKTHYPDVVMRERLAMCTNLPEARVQVWFKNRRAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SQHRKQRRSRTAFTAQQLEALEKTFQKTHYPDVVMRERLAMCTNLPEARVQVWFKNRRAK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 FRKKQRSLQKEQLQKQKEAEGSHGEGKAEAPTPDTQLDTEQPPRLPGSDPPAELHLSLSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FRKKQRSLQKEQLQKQKEAEGSHGEGKAEAPTPDTQLDTEQPPRLPGSDPPAELHLSLSE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 QSASESAPEDQPDREEDPRAGAEDPKAEKSPGADSKGLGCKRGSPKADSPGSLTITPVAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QSASESAPEDQPDREEDPRAGAEDPKAEKSPGADSKGLGCKRGSPKADSPGSLTITPVAP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 GGGLLGPSHSYSSSPLSLFRLQEQFRQHMAATNNLVHYSSFEVGGPAPAAAAAAAAVPYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GGGLLGPSHSYSSSPLSLFRLQEQFRQHMAATNNLVHYSSFEVGGPAPAAAAAAAAVPYL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB7 GVNMAPLGSLHCQSYYQSLSAAAAAHQGVWGSPLLPAPPAGLAPASATLNSKTTSIENLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GVNMAPLGSLHCQSYYQSLSAAAAAHQGVWGSPLLPAPPAGLAPASATLNSKTTSIENLR 310 320 330 340 350 360 370 pF1KB7 LRAKQHAASLGLDTLPN ::::::::::::::::: XP_011 LRAKQHAASLGLDTLPN 370 >>XP_016855778 (OMIM: 607410) PREDICTED: diencephalon/me (377 aa) initn: 2509 init1: 2509 opt: 2509 Z-score: 1549.2 bits: 295.3 E(85289): 1.5e-79 Smith-Waterman score: 2509; 100.0% identity (100.0% similar) in 377 aa overlap (1-377:1-377) 10 20 30 40 50 60 pF1KB7 MQHYGVNGYSLHAMNSLSAMYNLHQQAAQQAQHAPDYRPSVHALTLAERLADIILEARYG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MQHYGVNGYSLHAMNSLSAMYNLHQQAAQQAQHAPDYRPSVHALTLAERLADIILEARYG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 SQHRKQRRSRTAFTAQQLEALEKTFQKTHYPDVVMRERLAMCTNLPEARVQVWFKNRRAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SQHRKQRRSRTAFTAQQLEALEKTFQKTHYPDVVMRERLAMCTNLPEARVQVWFKNRRAK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 FRKKQRSLQKEQLQKQKEAEGSHGEGKAEAPTPDTQLDTEQPPRLPGSDPPAELHLSLSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FRKKQRSLQKEQLQKQKEAEGSHGEGKAEAPTPDTQLDTEQPPRLPGSDPPAELHLSLSE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 QSASESAPEDQPDREEDPRAGAEDPKAEKSPGADSKGLGCKRGSPKADSPGSLTITPVAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QSASESAPEDQPDREEDPRAGAEDPKAEKSPGADSKGLGCKRGSPKADSPGSLTITPVAP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 GGGLLGPSHSYSSSPLSLFRLQEQFRQHMAATNNLVHYSSFEVGGPAPAAAAAAAAVPYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GGGLLGPSHSYSSSPLSLFRLQEQFRQHMAATNNLVHYSSFEVGGPAPAAAAAAAAVPYL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB7 GVNMAPLGSLHCQSYYQSLSAAAAAHQGVWGSPLLPAPPAGLAPASATLNSKTTSIENLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GVNMAPLGSLHCQSYYQSLSAAAAAHQGVWGSPLLPAPPAGLAPASATLNSKTTSIENLR 310 320 330 340 350 360 370 pF1KB7 LRAKQHAASLGLDTLPN ::::::::::::::::: XP_016 LRAKQHAASLGLDTLPN 370 >>NP_671725 (OMIM: 607410) diencephalon/mesencephalon ho (382 aa) initn: 2495 init1: 2169 opt: 2489 Z-score: 1536.9 bits: 293.1 E(85289): 7.2e-79 Smith-Waterman score: 2489; 98.7% identity (98.7% similar) in 382 aa overlap (1-377:1-382) 10 20 30 40 50 pF1KB7 MQHYGVNGYSLHAMNSLSAMYNLHQQAAQQAQHAPDYRPSVHALTLAERLA-----DIIL ::::::::::::::::::::::::::::::::::::::::::::::::::: :::: NP_671 MQHYGVNGYSLHAMNSLSAMYNLHQQAAQQAQHAPDYRPSVHALTLAERLAGCTFQDIIL 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB7 EARYGSQHRKQRRSRTAFTAQQLEALEKTFQKTHYPDVVMRERLAMCTNLPEARVQVWFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_671 EARYGSQHRKQRRSRTAFTAQQLEALEKTFQKTHYPDVVMRERLAMCTNLPEARVQVWFK 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB7 NRRAKFRKKQRSLQKEQLQKQKEAEGSHGEGKAEAPTPDTQLDTEQPPRLPGSDPPAELH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_671 NRRAKFRKKQRSLQKEQLQKQKEAEGSHGEGKAEAPTPDTQLDTEQPPRLPGSDPPAELH 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB7 LSLSEQSASESAPEDQPDREEDPRAGAEDPKAEKSPGADSKGLGCKRGSPKADSPGSLTI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_671 LSLSEQSASESAPEDQPDREEDPRAGAEDPKAEKSPGADSKGLGCKRGSPKADSPGSLTI 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB7 TPVAPGGGLLGPSHSYSSSPLSLFRLQEQFRQHMAATNNLVHYSSFEVGGPAPAAAAAAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_671 TPVAPGGGLLGPSHSYSSSPLSLFRLQEQFRQHMAATNNLVHYSSFEVGGPAPAAAAAAA 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB7 AVPYLGVNMAPLGSLHCQSYYQSLSAAAAAHQGVWGSPLLPAPPAGLAPASATLNSKTTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_671 AVPYLGVNMAPLGSLHCQSYYQSLSAAAAAHQGVWGSPLLPAPPAGLAPASATLNSKTTS 310 320 330 340 350 360 360 370 pF1KB7 IENLRLRAKQHAASLGLDTLPN :::::::::::::::::::::: NP_671 IENLRLRAKQHAASLGLDTLPN 370 380 >>NP_000545 (OMIM: 120970,268000,602225,613829) cone-rod (299 aa) initn: 360 init1: 298 opt: 358 Z-score: 240.4 bits: 52.8 E(85289): 1.2e-06 Smith-Waterman score: 398; 39.3% identity (58.8% similar) in 257 aa overlap (31-257:3-254) 10 20 30 40 50 pF1KB7 MQHYGVNGYSLHAMNSLSAMYNLHQQAAQQAQHAPDYRPSVHALTLAERLADIILEAR-Y : : . ::.::.:. .:.. .: : NP_000 MMAYMNPGPHYSVNALALSGPSVDLMHQAVPY 10 20 30 60 70 80 90 100 110 pF1KB7 GSQHRKQRRSRTAFTAQQLEALEKTFQKTHYPDVVMRERLAMCTNLPEARVQVWFKNRRA : ::::: ::.:: .::: :: : ::.:::: ::..:. ::::.::::::::::: NP_000 PSAPRKQRRERTTFTRSQLEELEALFAKTQYPDVYAREEVALKINLPESRVQVWFKNRRA 40 50 60 70 80 90 120 130 140 150 160 pF1KB7 KFRKKQRSLQKEQLQKQK-EAEGSHGEGKA-EAPTPDTQL--------DTEQPPRLPG-S : :. ::. ::.: : .:.. .. :: .: :.:.. :. .:: ::: : NP_000 KCRQ-QRQQQKQQQQPPGGQAKARPAKRKAGTSPRPSTDVCPDPLGISDSYSPP-LPGPS 100 110 120 130 140 150 170 180 190 200 210 pF1KB7 DPPAELHLSLSEQS-ASESA-PEDQ--------PDREEDPRAGA--------EDPKAEKS :. ..: : :::: :: : :. : : . .:.: : NP_000 GSPTTAVATVSIWSPASESPLPEAQRAGLVASGPSLTSAPYAMTYAPASAFCSSPSAYGS 160 170 180 190 200 210 220 230 240 250 260 270 pF1KB7 PGADSKGLGCKRGSPKADSPGSLTITPVAPGGGLLGPSHSYSSSPLSLFRLQEQFRQHMA :.. .:: :: . . :. ...:.. : .::: . : . :: NP_000 PSSYFSGLD-PYLSPMVPQLGGPALSPLS--GPSVGPSLAQSPTSLSGQSYGAYSPVDSL 220 230 240 250 260 280 290 300 310 320 330 pF1KB7 ATNNLVHYSSFEVGGPAPAAAAAAAAVPYLGVNMAPLGSLHCQSYYQSLSAAAAAHQGVW NP_000 EFKDPTGTWKFTYNPMDPLDYKDQSAWKFQIL 270 280 290 >>NP_005020 (OMIM: 107250,602669,610623) pituitary homeo (302 aa) initn: 447 init1: 305 opt: 338 Z-score: 228.1 bits: 50.6 E(85289): 5.7e-06 Smith-Waterman score: 348; 34.4% identity (56.7% similar) in 247 aa overlap (60-290:56-289) 30 40 50 60 70 80 pF1KB7 QAQHAPDYRPSVHALTLAERLADIILEARYGSQHRKQRRSRTAFTAQQLEALEKTFQKTH :: ..::::.:: ::.:::. :: :::... NP_005 PQLPEHGCKGQEHSDSEKASASLPGGSPEDGSLKKKQRRQRTHFTSQQLQELEATFQRNR 30 40 50 60 70 80 90 100 110 120 130 140 pF1KB7 YPDVVMRERLAMCTNLPEARVQVWFKNRRAKFRKKQRSLQKEQLQKQKEAEGSHGEGKAE :::. ::..:. ::: ::::.:::::::::.::..:: : : . . : . : NP_005 YPDMSTREEIAVWTNLTEARVRVWFKNRRAKWRKRERSQQAELCKGSFAAPLGGLVPPYE 90 100 110 120 130 140 150 160 170 180 190 200 pF1KB7 APTPDTQLDTEQPPRLPGSDPPAELHLSLSEQSASESAPEDQPDREEDPRAGAED--PKA : . . : : . : : . .. .:.. . .:: : . : . :.: NP_005 EVYPGYSYGNWPPKAL--APPLAAKTFPFAFNSVNVGPLASQP-VFSPPSSIAASMVPSA 150 160 170 180 190 200 210 220 230 240 250 pF1KB7 EKSPGADS-----KGLGCKRGSPKADSPGSLTITPVA-PGGGLLGPSHSYSSSPL----- .::. .::: :.: . .:.... :. : .. . . . .::: NP_005 AAAPGTVPGPGALQGLG---GGPPGLAPAAVSSGAVSCPYASAAAAAAAAASSPYVYRDP 210 220 230 240 250 260 270 280 290 300 310 pF1KB7 ---SLFRLQEQFRQHMAATNNLVHYSSFEVGGPAPAAAAAAAAVPYLGVNMAPLGSLHCQ :: :. . .:: . . :: :: ::: NP_005 CNSSLASLRLKAKQHASFSYPAVH-------GPPPAANLSPCQYAVERPV 260 270 280 290 300 320 330 340 350 360 370 pF1KB7 SYYQSLSAAAAAHQGVWGSPLLPAPPAGLAPASATLNSKTTSIENLRLRAKQHAASLGLD >>NP_005160 (OMIM: 602078,602753) paired mesoderm homeob (284 aa) initn: 323 init1: 292 opt: 324 Z-score: 219.9 bits: 49.0 E(85289): 1.6e-05 Smith-Waterman score: 334; 38.2% identity (61.8% similar) in 186 aa overlap (62-234:86-265) 40 50 60 70 80 90 pF1KB7 QHAPDYRPSVHALTLAERLADIILEARYGSQHRKQRRSRTAFTAQQLEALEKTFQKTHYP ..::::: ::.::. ::. ::..: .:::: NP_005 NCALGALRDHQPAPYSAVPYKFFPEPSGLHEKRKQRRIRTTFTSAQLKELERVFAETHYP 60 70 80 90 100 110 100 110 120 130 140 pF1KB7 DVVMRERLAMCTNLPEARVQVWFKNRRAKFRKKQRSLQKEQLQ-----KQKEAEGSHGEG :. ::.::. .: ::::::::.::::::::..:. . . :. ::. : . NP_005 DIYTREELALKIDLTEARVQVWFQNRRAKFRKQERAASAKGAAGAAGAKKGEARCSSEDD 120 130 140 150 160 170 150 160 170 180 190 pF1KB7 KAE----APTPDTQLDTEQPPRLPG-SDP---PAELHLSLSEQSASESAPEDQPDREEDP .. .::::. . :: :: ..: :. : ..:. :. .: :: . NP_005 DSKESTCSPTPDSTASLPPPPA-PGLASPRLSPSPLPVALG--SGPGPGPGPQPLKGAL- 180 190 200 210 220 230 200 210 220 230 240 250 pF1KB7 RAGAEDPKAEKSPGADSKGLGCKRGSPKADSPGSLTITPVAPGGGLLGPSHSYSSSPLSL ::. . .::: . : : .: ..:: .. NP_005 WAGVAGGGG-GGPGAGAAEL-LKAWQPAESGPGPFSGVLSSFHRKPGPALKTNLF 240 250 260 270 280 260 270 280 290 300 310 pF1KB7 FRLQEQFRQHMAATNNLVHYSSFEVGGPAPAAAAAAAAVPYLGVNMAPLGSLHCQSYYQS >>NP_006483 (OMIM: 136760,606014) homeobox protein arist (343 aa) initn: 333 init1: 284 opt: 323 Z-score: 218.4 bits: 49.0 E(85289): 2e-05 Smith-Waterman score: 323; 38.2% identity (55.5% similar) in 220 aa overlap (40-244:131-339) 10 20 30 40 50 60 pF1KB7 SLHAMNSLSAMYNLHQQAAQQAQHAPDYRPSVHALTLAERLADIILEARYGSQHRKQRRS :.: : :. : : . :. : :.::. NP_006 ASFPQLPLDCRGGPRDGPSNLQGSPGPCLASLH-LPLSPGLPDSMELAKNKS---KKRRN 110 120 130 140 150 70 80 90 100 110 120 pF1KB7 RTAFTAQQLEALEKTFQKTHYPDVVMRERLAMCTNLPEARVQVWFKNRRAKFRKKQRSLQ ::.:.. ::: :::.::::::::: ::.::. :.: ::::::::.:::::.::..: NP_006 RTTFSTFQLEELEKVFQKTHYPDVYAREQLALRTDLTEARVQVWFQNRRAKWRKRER--- 160 170 180 190 200 210 130 140 150 160 170 180 pF1KB7 KEQLQKQKEAEGSHGEGKAEAPTPDTQLDTEQPPRL---PGSDPPAELHLSLSEQSASES : .:... . . : :. . : ::: :. : : : NP_006 ---YGKIQEGRNPFTAAYDISVLPRTDSHPQLQNSLWASPGSGSPGGPCLVSPEGIPSPC 220 230 240 250 260 270 190 200 210 220 230 pF1KB7 -APEDQPDREEDPRAGAEDPKAEKSPGADS-KG----LGCKRGSPKAD----SPG--SLT .: ..: :. :.: . :: : .: :: . :..: ::. :: NP_006 MSPYSHPHGSVAGFMGVPAPSAAH-PGIYSIHGFPPTLGGHSFEPSSDGDYKSPSLVSLR 280 290 300 310 320 240 250 260 270 280 290 pF1KB7 ITPVAPGGGLLGPSHSYSSSPLSLFRLQEQFRQHMAATNNLVHYSSFEVGGPAPAAAAAA . : : : : NP_006 VKPKEPPGLLNWTT 330 340 >>NP_878314 (OMIM: 142993,610092,610093) visual system h (361 aa) initn: 310 init1: 289 opt: 323 Z-score: 218.1 bits: 49.0 E(85289): 2.1e-05 Smith-Waterman score: 323; 35.9% identity (64.7% similar) in 156 aa overlap (61-215:143-294) 40 50 60 70 80 90 pF1KB7 AQHAPDYRPSVHALTLAERLADIILEARYGSQHRKQRRSRTAFTAQQLEALEKTFQKTHY ...::.:: :: ::. ::: :::.:...:: NP_878 GPLDTSQTASSDSEDVSSSDRKMSKSALNQTKKRKKRRHRTIFTSYQLEELEKAFNEAHY 120 130 140 150 160 170 100 110 120 130 140 pF1KB7 PDVVMRERLAMCTNLPEARVQVWFKNRRAKFRKKQRSLQKEQLQKQKEAEGSHGEG-KAE ::: :: ::: :.::: :.::::.:::::.::... . ... . : .: . NP_878 PDVYAREMLAMKTELPEDRIQVWFQNRRAKWRKREKCWGRSSVMAEY---GLYGAMVRHS 180 190 200 210 220 150 160 170 180 190 200 pF1KB7 APTPDTQLDTEQPPRLPGSDPPAELHLSLSEQSASESAPEDQPDREEDPRAGAEDPKAEK : :.. : . . . . : . : ..:.::. . . .:. :. . . :. NP_878 IPLPESILKSAKDGIMDSCAPWLLGMHKKSLEAAAESGRKPEGERQALPKLDKME-QDER 230 240 250 260 270 280 210 220 230 240 250 260 pF1KB7 SPGADSKGLGCKRGSPKADSPGSLTITPVAPGGGLLGPSHSYSSSPLSLFRLQEQFRQHM .: :.. NP_878 GPDAQAAISQEELRENSIAVLRAKAQEHSTKVLGTVSGPDSLARSTEKPEEEEAMDEDRP 290 300 310 320 330 340 >>NP_003915 (OMIM: 209880,603851,613013) paired mesoderm (314 aa) initn: 354 init1: 305 opt: 319 Z-score: 216.4 bits: 48.5 E(85289): 2.6e-05 Smith-Waterman score: 322; 31.0% identity (59.9% similar) in 197 aa overlap (61-255:93-277) 40 50 60 70 80 90 pF1KB7 AQHAPDYRPSVHALTLAERLADIILEARYGSQHRKQRRSRTAFTAQQLEALEKTFQKTHY ...::::: ::.::. ::. ::..: .::: NP_003 GSCSLGTLRDHQSSPYAAVPYKLFTDHGGLNEKRKQRRIRTTFTSAQLKELERVFAETHY 70 80 90 100 110 120 100 110 120 130 140 150 pF1KB7 PDVVMRERLAMCTNLPEARVQVWFKNRRAKFRKKQRSLQKEQLQKQKEAEGSHGEGKAEA ::. ::.::. .: ::::::::.::::::::..:. .. . :...... . NP_003 PDIYTREELALKIDLTEARVQVWFQNRRAKFRKQERAAAAAAAAAKNGSSGKKSDSSRDD 130 140 150 160 170 180 160 170 180 190 200 210 pF1KB7 PTPDTQLDTEQPPRLPGSDPPAELHLSLSEQSASESAPEDQPDREEDPRAGAEDPKAEKS . ... . :: .: . . ... .: : :: : . NP_003 ESKEAKSTDPDSTGGPGPNPNPTPSCGANGGGGGGPSPAGAP--------GAAGPG---G 190 200 210 220 230 220 230 240 250 260 pF1KB7 PGADSKGLGCKRGSPKADSPGSLTITPVAPGG--GLLGPSHSYSSSPLSLFRLQEQFRQH ::.. : : .. : . .. . . .: :: . ::..... .: NP_003 PGGEP-GKGGAAAAAAAAAAAAAAAAAAAAGGLAAAGGPGQGWAPGPGPITSIPDSLGGP 240 250 260 270 280 290 270 280 290 300 310 320 pF1KB7 MAATNNLVHYSSFEVGGPAPAAAAAAAAVPYLGVNMAPLGSLHCQSYYQSLSAAAAAHQG NP_003 FASVLSSLQRPNGAKAALVKSSMF 300 310 377 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 16:27:12 2016 done: Sat Nov 5 16:27:13 2016 Total Scan time: 10.780 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]