FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB7944, 246 aa 1>>>pF1KB7944 246 - 246 aa - 246 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.9475+/-0.000304; mu= 5.0952+/- 0.019 mean_var=210.4999+/-41.855, 0's: 0 Z-trim(123.9): 11 B-trim: 50 in 1/55 Lambda= 0.088399 statistics sampled from 44436 (44447) to 44436 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.821), E-opt: 0.2 (0.521), width: 16 Scan time: 7.950 The best scores are: opt bits E(85289) NP_005577 (OMIM: 604971) myoD family inhibitor iso ( 246) 1801 241.1 1.3e-63 NP_001287735 (OMIM: 604971) myoD family inhibitor ( 246) 1801 241.1 1.3e-63 NP_001287733 (OMIM: 604971) myoD family inhibitor ( 246) 1801 241.1 1.3e-63 XP_005249174 (OMIM: 604971) PREDICTED: myoD family ( 229) 1622 218.3 9.6e-57 XP_011512927 (OMIM: 604971) PREDICTED: myoD family ( 229) 1622 218.3 9.6e-57 XP_016866356 (OMIM: 604971) PREDICTED: myoD family ( 186) 1397 189.5 3.6e-48 NP_001287734 (OMIM: 604971) myoD family inhibitor ( 185) 1211 165.7 4.9e-41 XP_011512928 (OMIM: 604971) PREDICTED: myoD family ( 185) 1211 165.7 4.9e-41 NP_001159817 (OMIM: 614511) myoD family inhibitor ( 246) 611 89.4 6.5e-18 NP_951038 (OMIM: 614511) myoD family inhibitor dom ( 355) 611 89.5 8.5e-18 >>NP_005577 (OMIM: 604971) myoD family inhibitor isoform (246 aa) initn: 1801 init1: 1801 opt: 1801 Z-score: 1262.7 bits: 241.1 E(85289): 1.3e-63 Smith-Waterman score: 1801; 100.0% identity (100.0% similar) in 246 aa overlap (1-246:1-246) 10 20 30 40 50 60 pF1KB7 MYQVSGQRPSGCDAPYGAPSAAPGPAQTLSLLPGLEVVTGSTHPAEAAPEEGSLEEAATP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MYQVSGQRPSGCDAPYGAPSAAPGPAQTLSLLPGLEVVTGSTHPAEAAPEEGSLEEAATP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 MPQGNGPGIPQGLDSTDLDVPTEAVTCQPQGNPLGCTPLLPNDSGHPSELGGTRRAGNGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MPQGNGPGIPQGLDSTDLDVPTEAVTCQPQGNPLGCTPLLPNDSGHPSELGGTRRAGNGA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 LGGPKAHRKLQTHPSLASQGSKKSKSSSKSTTSQIPLQAQEDCCVHCILSCLFCEFLTLC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 LGGPKAHRKLQTHPSLASQGSKKSKSSSKSTTSQIPLQAQEDCCVHCILSCLFCEFLTLC 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 NIVLDCATCGSCSSEDSCLCCCCCGSGECADCDLPCDLDCGILDACCESADCLEICMECC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 NIVLDCATCGSCSSEDSCLCCCCCGSGECADCDLPCDLDCGILDACCESADCLEICMECC 190 200 210 220 230 240 pF1KB7 GLCFSS :::::: NP_005 GLCFSS >>NP_001287735 (OMIM: 604971) myoD family inhibitor isof (246 aa) initn: 1801 init1: 1801 opt: 1801 Z-score: 1262.7 bits: 241.1 E(85289): 1.3e-63 Smith-Waterman score: 1801; 100.0% identity (100.0% similar) in 246 aa overlap (1-246:1-246) 10 20 30 40 50 60 pF1KB7 MYQVSGQRPSGCDAPYGAPSAAPGPAQTLSLLPGLEVVTGSTHPAEAAPEEGSLEEAATP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MYQVSGQRPSGCDAPYGAPSAAPGPAQTLSLLPGLEVVTGSTHPAEAAPEEGSLEEAATP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 MPQGNGPGIPQGLDSTDLDVPTEAVTCQPQGNPLGCTPLLPNDSGHPSELGGTRRAGNGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MPQGNGPGIPQGLDSTDLDVPTEAVTCQPQGNPLGCTPLLPNDSGHPSELGGTRRAGNGA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 LGGPKAHRKLQTHPSLASQGSKKSKSSSKSTTSQIPLQAQEDCCVHCILSCLFCEFLTLC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LGGPKAHRKLQTHPSLASQGSKKSKSSSKSTTSQIPLQAQEDCCVHCILSCLFCEFLTLC 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 NIVLDCATCGSCSSEDSCLCCCCCGSGECADCDLPCDLDCGILDACCESADCLEICMECC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NIVLDCATCGSCSSEDSCLCCCCCGSGECADCDLPCDLDCGILDACCESADCLEICMECC 190 200 210 220 230 240 pF1KB7 GLCFSS :::::: NP_001 GLCFSS >>NP_001287733 (OMIM: 604971) myoD family inhibitor isof (246 aa) initn: 1801 init1: 1801 opt: 1801 Z-score: 1262.7 bits: 241.1 E(85289): 1.3e-63 Smith-Waterman score: 1801; 100.0% identity (100.0% similar) in 246 aa overlap (1-246:1-246) 10 20 30 40 50 60 pF1KB7 MYQVSGQRPSGCDAPYGAPSAAPGPAQTLSLLPGLEVVTGSTHPAEAAPEEGSLEEAATP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MYQVSGQRPSGCDAPYGAPSAAPGPAQTLSLLPGLEVVTGSTHPAEAAPEEGSLEEAATP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 MPQGNGPGIPQGLDSTDLDVPTEAVTCQPQGNPLGCTPLLPNDSGHPSELGGTRRAGNGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MPQGNGPGIPQGLDSTDLDVPTEAVTCQPQGNPLGCTPLLPNDSGHPSELGGTRRAGNGA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 LGGPKAHRKLQTHPSLASQGSKKSKSSSKSTTSQIPLQAQEDCCVHCILSCLFCEFLTLC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LGGPKAHRKLQTHPSLASQGSKKSKSSSKSTTSQIPLQAQEDCCVHCILSCLFCEFLTLC 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 NIVLDCATCGSCSSEDSCLCCCCCGSGECADCDLPCDLDCGILDACCESADCLEICMECC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NIVLDCATCGSCSSEDSCLCCCCCGSGECADCDLPCDLDCGILDACCESADCLEICMECC 190 200 210 220 230 240 pF1KB7 GLCFSS :::::: NP_001 GLCFSS >>XP_005249174 (OMIM: 604971) PREDICTED: myoD family inh (229 aa) initn: 1614 init1: 1614 opt: 1622 Z-score: 1139.8 bits: 218.3 E(85289): 9.6e-57 Smith-Waterman score: 1622; 98.2% identity (98.2% similar) in 228 aa overlap (19-246:3-229) 10 20 30 40 50 60 pF1KB7 MYQVSGQRPSGCDAPYGAPSAAPGPAQTLSLLPGLEVVTGSTHPAEAAPEEGSLEEAATP : : : ::::::::::::::::::::::::::::::::::: XP_005 MEPPAQPR-AQTLSLLPGLEVVTGSTHPAEAAPEEGSLEEAATP 10 20 30 40 70 80 90 100 110 120 pF1KB7 MPQGNGPGIPQGLDSTDLDVPTEAVTCQPQGNPLGCTPLLPNDSGHPSELGGTRRAGNGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MPQGNGPGIPQGLDSTDLDVPTEAVTCQPQGNPLGCTPLLPNDSGHPSELGGTRRAGNGA 50 60 70 80 90 100 130 140 150 160 170 180 pF1KB7 LGGPKAHRKLQTHPSLASQGSKKSKSSSKSTTSQIPLQAQEDCCVHCILSCLFCEFLTLC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LGGPKAHRKLQTHPSLASQGSKKSKSSSKSTTSQIPLQAQEDCCVHCILSCLFCEFLTLC 110 120 130 140 150 160 190 200 210 220 230 240 pF1KB7 NIVLDCATCGSCSSEDSCLCCCCCGSGECADCDLPCDLDCGILDACCESADCLEICMECC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NIVLDCATCGSCSSEDSCLCCCCCGSGECADCDLPCDLDCGILDACCESADCLEICMECC 170 180 190 200 210 220 pF1KB7 GLCFSS :::::: XP_005 GLCFSS >>XP_011512927 (OMIM: 604971) PREDICTED: myoD family inh (229 aa) initn: 1614 init1: 1614 opt: 1622 Z-score: 1139.8 bits: 218.3 E(85289): 9.6e-57 Smith-Waterman score: 1622; 98.2% identity (98.2% similar) in 228 aa overlap (19-246:3-229) 10 20 30 40 50 60 pF1KB7 MYQVSGQRPSGCDAPYGAPSAAPGPAQTLSLLPGLEVVTGSTHPAEAAPEEGSLEEAATP : : : ::::::::::::::::::::::::::::::::::: XP_011 MEPPAQPR-AQTLSLLPGLEVVTGSTHPAEAAPEEGSLEEAATP 10 20 30 40 70 80 90 100 110 120 pF1KB7 MPQGNGPGIPQGLDSTDLDVPTEAVTCQPQGNPLGCTPLLPNDSGHPSELGGTRRAGNGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MPQGNGPGIPQGLDSTDLDVPTEAVTCQPQGNPLGCTPLLPNDSGHPSELGGTRRAGNGA 50 60 70 80 90 100 130 140 150 160 170 180 pF1KB7 LGGPKAHRKLQTHPSLASQGSKKSKSSSKSTTSQIPLQAQEDCCVHCILSCLFCEFLTLC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LGGPKAHRKLQTHPSLASQGSKKSKSSSKSTTSQIPLQAQEDCCVHCILSCLFCEFLTLC 110 120 130 140 150 160 190 200 210 220 230 240 pF1KB7 NIVLDCATCGSCSSEDSCLCCCCCGSGECADCDLPCDLDCGILDACCESADCLEICMECC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NIVLDCATCGSCSSEDSCLCCCCCGSGECADCDLPCDLDCGILDACCESADCLEICMECC 170 180 190 200 210 220 pF1KB7 GLCFSS :::::: XP_011 GLCFSS >>XP_016866356 (OMIM: 604971) PREDICTED: myoD family inh (186 aa) initn: 1397 init1: 1397 opt: 1397 Z-score: 985.8 bits: 189.5 E(85289): 3.6e-48 Smith-Waterman score: 1397; 100.0% identity (100.0% similar) in 186 aa overlap (61-246:1-186) 40 50 60 70 80 90 pF1KB7 LLPGLEVVTGSTHPAEAAPEEGSLEEAATPMPQGNGPGIPQGLDSTDLDVPTEAVTCQPQ :::::::::::::::::::::::::::::: XP_016 MPQGNGPGIPQGLDSTDLDVPTEAVTCQPQ 10 20 30 100 110 120 130 140 150 pF1KB7 GNPLGCTPLLPNDSGHPSELGGTRRAGNGALGGPKAHRKLQTHPSLASQGSKKSKSSSKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GNPLGCTPLLPNDSGHPSELGGTRRAGNGALGGPKAHRKLQTHPSLASQGSKKSKSSSKS 40 50 60 70 80 90 160 170 180 190 200 210 pF1KB7 TTSQIPLQAQEDCCVHCILSCLFCEFLTLCNIVLDCATCGSCSSEDSCLCCCCCGSGECA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TTSQIPLQAQEDCCVHCILSCLFCEFLTLCNIVLDCATCGSCSSEDSCLCCCCCGSGECA 100 110 120 130 140 150 220 230 240 pF1KB7 DCDLPCDLDCGILDACCESADCLEICMECCGLCFSS :::::::::::::::::::::::::::::::::::: XP_016 DCDLPCDLDCGILDACCESADCLEICMECCGLCFSS 160 170 180 >>NP_001287734 (OMIM: 604971) myoD family inhibitor isof (185 aa) initn: 1204 init1: 1204 opt: 1211 Z-score: 857.7 bits: 165.7 E(85289): 4.9e-41 Smith-Waterman score: 1259; 74.8% identity (75.2% similar) in 246 aa overlap (1-246:1-185) 10 20 30 40 50 60 pF1KB7 MYQVSGQRPSGCDAPYGAPSAAPGPAQTLSLLPGLEVVTGSTHPAEAAPEEGSLEEAATP :::::::::::::::::::::::::.: NP_001 MYQVSGQRPSGCDAPYGAPSAAPGPGQ--------------------------------- 10 20 70 80 90 100 110 120 pF1KB7 MPQGNGPGIPQGLDSTDLDVPTEAVTCQPQGNPLGCTPLLPNDSGHPSELGGTRRAGNGA :::::::::::::::::::::::::::::::: NP_001 ----------------------------PQGNPLGCTPLLPNDSGHPSELGGTRRAGNGA 30 40 50 130 140 150 160 170 180 pF1KB7 LGGPKAHRKLQTHPSLASQGSKKSKSSSKSTTSQIPLQAQEDCCVHCILSCLFCEFLTLC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LGGPKAHRKLQTHPSLASQGSKKSKSSSKSTTSQIPLQAQEDCCVHCILSCLFCEFLTLC 60 70 80 90 100 110 190 200 210 220 230 240 pF1KB7 NIVLDCATCGSCSSEDSCLCCCCCGSGECADCDLPCDLDCGILDACCESADCLEICMECC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NIVLDCATCGSCSSEDSCLCCCCCGSGECADCDLPCDLDCGILDACCESADCLEICMECC 120 130 140 150 160 170 pF1KB7 GLCFSS :::::: NP_001 GLCFSS 180 >>XP_011512928 (OMIM: 604971) PREDICTED: myoD family inh (185 aa) initn: 1204 init1: 1204 opt: 1211 Z-score: 857.7 bits: 165.7 E(85289): 4.9e-41 Smith-Waterman score: 1259; 74.8% identity (75.2% similar) in 246 aa overlap (1-246:1-185) 10 20 30 40 50 60 pF1KB7 MYQVSGQRPSGCDAPYGAPSAAPGPAQTLSLLPGLEVVTGSTHPAEAAPEEGSLEEAATP :::::::::::::::::::::::::.: XP_011 MYQVSGQRPSGCDAPYGAPSAAPGPGQ--------------------------------- 10 20 70 80 90 100 110 120 pF1KB7 MPQGNGPGIPQGLDSTDLDVPTEAVTCQPQGNPLGCTPLLPNDSGHPSELGGTRRAGNGA :::::::::::::::::::::::::::::::: XP_011 ----------------------------PQGNPLGCTPLLPNDSGHPSELGGTRRAGNGA 30 40 50 130 140 150 160 170 180 pF1KB7 LGGPKAHRKLQTHPSLASQGSKKSKSSSKSTTSQIPLQAQEDCCVHCILSCLFCEFLTLC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LGGPKAHRKLQTHPSLASQGSKKSKSSSKSTTSQIPLQAQEDCCVHCILSCLFCEFLTLC 60 70 80 90 100 110 190 200 210 220 230 240 pF1KB7 NIVLDCATCGSCSSEDSCLCCCCCGSGECADCDLPCDLDCGILDACCESADCLEICMECC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NIVLDCATCGSCSSEDSCLCCCCCGSGECADCDLPCDLDCGILDACCESADCLEICMECC 120 130 140 150 160 170 pF1KB7 GLCFSS :::::: XP_011 GLCFSS 180 >>NP_001159817 (OMIM: 614511) myoD family inhibitor doma (246 aa) initn: 705 init1: 341 opt: 611 Z-score: 442.5 bits: 89.4 E(85289): 6.5e-18 Smith-Waterman score: 613; 43.4% identity (61.7% similar) in 256 aa overlap (17-246:3-246) 10 20 30 40 50 pF1KB7 MYQVSGQRPSGCDAPYGAPSA-APGPA--QTLSLLPGLEVVTGSTHPAEAAPEEGSLEEA :: : ::::. : .. : .. ::: :.. .. . :. NP_001 MSGAGEALAPGPVGPQRVAEAGGGQL--GST--AQGKCDKDNTEKD 10 20 30 40 60 70 80 90 100 pF1KB7 ATPMPQGNGPGIPQG--LDSTDLDVPT--EAVTCQPQGNP-LGCTPLLPND-------SG : :... . .: :.. :. : . ::: : : . .:. .: NP_001 IT---QATNSHFTHGEMQDQSIWGNPSDGELIRTQPQRLPQLQTSAQVPSGEEIGKIKNG 50 60 70 80 90 110 120 130 140 150 pF1KB7 HPSELGGTR--------RAGNGALGGP---KAHRKLQTHPSLASQGSKKSKSSSKSTTSQ : . .:. : : :..: : :::.:. :. :. ::::: .. . :: NP_001 HTGLSNGNGIHHGAKHGSADNRKLSAPVSQKMHRKIQSSLSVNSDISKKSKVNA--VFSQ 100 110 120 130 140 150 160 170 180 190 200 210 pF1KB7 IPLQAQEDCCVHCILSCLFCEFLTLCNIVLDCATCGSCSSEDSCLCCCCCGSGECADCDL .. :::::::::.:::::::::::::: :.:: :.:: ::::::. ::. NP_001 KTGSSPEDCCVHCILACLFCEFLTLCNIVLGQASCGICTSE---ACCCCCGDEMGDDCNC 160 170 180 190 200 210 220 230 240 pF1KB7 PCDLDCGILDACCESADCLEICMECCGLCFSS :::.::::.::::::.:::::::::::.:: : NP_001 PCDMDCGIMDACCESSDCLEICMECCGICFPS 220 230 240 >>NP_951038 (OMIM: 614511) myoD family inhibitor domain- (355 aa) initn: 705 init1: 341 opt: 611 Z-score: 440.5 bits: 89.5 E(85289): 8.5e-18 Smith-Waterman score: 615; 42.5% identity (61.2% similar) in 268 aa overlap (5-246:105-355) 10 20 30 pF1KB7 MYQVSGQRPSGCDAPYGAPSA-APGPA--QTLSL :..:: . :: : ::::. : .. NP_951 AVSSLHPAPHSPSSVRPAGRRARRQRRGAGSAERPMS-----GAGEALAPGPVGPQRVAE 80 90 100 110 120 40 50 60 70 80 pF1KB7 LPGLEVVTGSTHPAEAAPEEGSLEEAATPMPQGNGPGIPQG--LDSTDLDVPT--EAVTC : .. ::: :.. .. . :. : :... . .: :.. :. : . NP_951 AGGGQL--GST--AQGKCDKDNTEKDIT---QATNSHFTHGEMQDQSIWGNPSDGELIRT 130 140 150 160 170 180 90 100 110 120 pF1KB7 QPQGNP-LGCTPLLPND-------SGHPSELGGTR--------RAGNGALGGP---KAHR ::: : : . .:. .:: . .:. : : :..: : :: NP_951 QPQRLPQLQTSAQVPSGEEIGKIKNGHTGLSNGNGIHHGAKHGSADNRKLSAPVSQKMHR 190 200 210 220 230 240 130 140 150 160 170 180 pF1KB7 KLQTHPSLASQGSKKSKSSSKSTTSQIPLQAQEDCCVHCILSCLFCEFLTLCNIVLDCAT :.:. :. :. ::::: . .. :: .. :::::::::.:::::::::::::: :. NP_951 KIQSSLSVNSDISKKSKVN--AVFSQKTGSSPEDCCVHCILACLFCEFLTLCNIVLGQAS 250 260 270 280 290 300 190 200 210 220 230 240 pF1KB7 CGSCSSEDSCLCCCCCGSGECADCDLPCDLDCGILDACCESADCLEICMECCGLCFSS :: :.:: ::::::. ::. :::.::::.::::::.:::::::::::.:: : NP_951 CGICTSEA---CCCCCGDEMGDDCNCPCDMDCGIMDACCESSDCLEICMECCGICFPS 310 320 330 340 350 246 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 14:42:42 2016 done: Sat Nov 5 14:42:43 2016 Total Scan time: 7.950 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]