FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB7948, 375 aa 1>>>pF1KB7948 375 - 375 aa - 375 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.1543+/-0.000376; mu= 17.2424+/- 0.024 mean_var=235.3791+/-52.656, 0's: 0 Z-trim(119.7): 406 B-trim: 1783 in 1/57 Lambda= 0.083597 statistics sampled from 33520 (34068) to 33520 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.734), E-opt: 0.2 (0.399), width: 16 Scan time: 8.730 The best scores are: opt bits E(85289) NP_003243 (OMIM: 603413) nucleolysin TIAR isoform ( 375) 2624 329.2 9.2e-90 NP_001310898 (OMIM: 603413) nucleolysin TIAR isofo ( 336) 2359 297.2 3.7e-80 NP_001310899 (OMIM: 603413) nucleolysin TIAR isofo ( 353) 2341 295.1 1.7e-79 NP_001029097 (OMIM: 603413) nucleolysin TIAR isofo ( 392) 2341 295.1 1.8e-79 NP_001310897 (OMIM: 603413) nucleolysin TIAR isofo ( 360) 2311 291.5 2.1e-78 XP_005264584 (OMIM: 603518,604454) PREDICTED: nucl ( 374) 2043 259.2 1.1e-68 NP_071320 (OMIM: 603518,604454) nucleolysin TIA-1 ( 375) 2041 258.9 1.4e-68 XP_016860279 (OMIM: 603518,604454) PREDICTED: nucl ( 338) 1829 233.3 6.4e-61 NP_001310896 (OMIM: 603413) nucleolysin TIAR isofo ( 252) 1794 228.9 1e-59 NP_001310893 (OMIM: 603413) nucleolysin TIAR isofo ( 252) 1794 228.9 1e-59 XP_016872095 (OMIM: 603413) PREDICTED: nucleolysin ( 252) 1794 228.9 1e-59 NP_001310894 (OMIM: 603413) nucleolysin TIAR isofo ( 252) 1794 228.9 1e-59 XP_016860280 (OMIM: 603518,604454) PREDICTED: nucl ( 310) 1686 216.0 9.5e-56 XP_011531379 (OMIM: 603518,604454) PREDICTED: nucl ( 385) 1518 195.9 1.3e-49 XP_005264585 (OMIM: 603518,604454) PREDICTED: nucl ( 321) 1516 195.5 1.4e-49 XP_016860278 (OMIM: 603518,604454) PREDICTED: nucl ( 349) 1516 195.6 1.5e-49 NP_071505 (OMIM: 603518,604454) nucleolysin TIA-1 ( 386) 1516 195.6 1.6e-49 XP_005264588 (OMIM: 603518,604454) PREDICTED: nucl ( 285) 1508 194.5 2.6e-49 XP_016860284 (OMIM: 603518,604454) PREDICTED: nucl ( 285) 1508 194.5 2.6e-49 XP_016860283 (OMIM: 603518,604454) PREDICTED: nucl ( 286) 1320 171.8 1.8e-42 XP_016860282 (OMIM: 603518,604454) PREDICTED: nucl ( 286) 1320 171.8 1.8e-42 XP_016860281 (OMIM: 603518,604454) PREDICTED: nucl ( 286) 1320 171.8 1.8e-42 XP_011531383 (OMIM: 603518,604454) PREDICTED: nucl ( 286) 1320 171.8 1.8e-42 XP_011531384 (OMIM: 603518,604454) PREDICTED: nucl ( 286) 1320 171.8 1.8e-42 XP_011531380 (OMIM: 603518,604454) PREDICTED: nucl ( 286) 1320 171.8 1.8e-42 XP_016860287 (OMIM: 603518,604454) PREDICTED: nucl ( 246) 1276 166.4 6.5e-41 XP_016860286 (OMIM: 603518,604454) PREDICTED: nucl ( 246) 1276 166.4 6.5e-41 XP_016860285 (OMIM: 603518,604454) PREDICTED: nucl ( 246) 1276 166.4 6.5e-41 XP_016860288 (OMIM: 603518,604454) PREDICTED: nucl ( 246) 1276 166.4 6.5e-41 XP_016860289 (OMIM: 603518,604454) PREDICTED: nucl ( 246) 1276 166.4 6.5e-41 NP_112241 (OMIM: 604680) polyadenylate-binding pro ( 631) 441 66.3 2.2e-10 NP_005372 (OMIM: 164035) nucleolin [Homo sapiens] ( 710) 261 44.7 0.00079 XP_016881347 (OMIM: 612679) PREDICTED: CUGBP Elav- ( 456) 247 42.7 0.002 XP_016871044 (OMIM: 602538) PREDICTED: CUGBP Elav- ( 356) 241 41.8 0.003 XP_016872614 (OMIM: 601074) PREDICTED: CUGBP Elav- ( 486) 235 41.3 0.0057 XP_016872613 (OMIM: 601074) PREDICTED: CUGBP Elav- ( 486) 235 41.3 0.0057 XP_016872618 (OMIM: 601074) PREDICTED: CUGBP Elav- ( 486) 235 41.3 0.0057 XP_016872619 (OMIM: 601074) PREDICTED: CUGBP Elav- ( 486) 235 41.3 0.0057 XP_016872615 (OMIM: 601074) PREDICTED: CUGBP Elav- ( 486) 235 41.3 0.0057 XP_016872621 (OMIM: 601074) PREDICTED: CUGBP Elav- ( 486) 235 41.3 0.0057 NP_001020767 (OMIM: 601074) CUGBP Elav-like family ( 486) 235 41.3 0.0057 XP_016872620 (OMIM: 601074) PREDICTED: CUGBP Elav- ( 486) 235 41.3 0.0057 XP_016872617 (OMIM: 601074) PREDICTED: CUGBP Elav- ( 486) 235 41.3 0.0057 XP_016872616 (OMIM: 601074) PREDICTED: CUGBP Elav- ( 486) 235 41.3 0.0057 XP_016872604 (OMIM: 601074) PREDICTED: CUGBP Elav- ( 487) 235 41.3 0.0057 XP_011518158 (OMIM: 601074) PREDICTED: CUGBP Elav- ( 487) 235 41.3 0.0057 XP_016872609 (OMIM: 601074) PREDICTED: CUGBP Elav- ( 487) 235 41.3 0.0057 XP_011518157 (OMIM: 601074) PREDICTED: CUGBP Elav- ( 487) 235 41.3 0.0057 XP_011518159 (OMIM: 601074) PREDICTED: CUGBP Elav- ( 487) 235 41.3 0.0057 XP_011518160 (OMIM: 601074) PREDICTED: CUGBP Elav- ( 487) 235 41.3 0.0057 >>NP_003243 (OMIM: 603413) nucleolysin TIAR isoform 1 [H (375 aa) initn: 2624 init1: 2624 opt: 2624 Z-score: 1732.5 bits: 329.2 E(85289): 9.2e-90 Smith-Waterman score: 2624; 100.0% identity (100.0% similar) in 375 aa overlap (1-375:1-375) 10 20 30 40 50 60 pF1KB7 MMEDDGQPRTLYVGNLSRDVTEVLILQLFSQIGPCKSCKMITEHTSNDPYCFVEFYEHRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 MMEDDGQPRTLYVGNLSRDVTEVLILQLFSQIGPCKSCKMITEHTSNDPYCFVEFYEHRD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 AAAALAAMNGRKILGKEVKVNWATTPSSQKKDTSNHFHVFVGDLSPEITTEDIKSAFAPF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 AAAALAAMNGRKILGKEVKVNWATTPSSQKKDTSNHFHVFVGDLSPEITTEDIKSAFAPF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 GKISDARVVKDMATGKSKGYGFVSFYNKLDAENAIVHMGGQWLGGRQIRTNWATRKPPAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 GKISDARVVKDMATGKSKGYGFVSFYNKLDAENAIVHMGGQWLGGRQIRTNWATRKPPAP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 KSTQENNTKQLRFEDVVNQSSPKNCTVYCGGIASGLTDQLMRQTFSPFGQIMEIRVFPEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 KSTQENNTKQLRFEDVVNQSSPKNCTVYCGGIASGLTDQLMRQTFSPFGQIMEIRVFPEK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 GYSFVRFSTHESAAHAIVSVNGTTIEGHVVKCYWGKESPDMTKNFQQVDYSQWGQWSQVY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 GYSFVRFSTHESAAHAIVSVNGTTIEGHVVKCYWGKESPDMTKNFQQVDYSQWGQWSQVY 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB7 GNPQQYGQYMANGWQVPPYGVYGQPWNQQGFGVDQSPSAAWMGGFGAQPPQGQAPPPVIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 GNPQQYGQYMANGWQVPPYGVYGQPWNQQGFGVDQSPSAAWMGGFGAQPPQGQAPPPVIP 310 320 330 340 350 360 370 pF1KB7 PPNQAGYGMASYQTQ ::::::::::::::: NP_003 PPNQAGYGMASYQTQ 370 >>NP_001310898 (OMIM: 603413) nucleolysin TIAR isoform 5 (336 aa) initn: 2359 init1: 2359 opt: 2359 Z-score: 1560.2 bits: 297.2 E(85289): 3.7e-80 Smith-Waterman score: 2359; 100.0% identity (100.0% similar) in 336 aa overlap (40-375:1-336) 10 20 30 40 50 60 pF1KB7 TLYVGNLSRDVTEVLILQLFSQIGPCKSCKMITEHTSNDPYCFVEFYEHRDAAAALAAMN :::::::::::::::::::::::::::::: NP_001 MITEHTSNDPYCFVEFYEHRDAAAALAAMN 10 20 30 70 80 90 100 110 120 pF1KB7 GRKILGKEVKVNWATTPSSQKKDTSNHFHVFVGDLSPEITTEDIKSAFAPFGKISDARVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GRKILGKEVKVNWATTPSSQKKDTSNHFHVFVGDLSPEITTEDIKSAFAPFGKISDARVV 40 50 60 70 80 90 130 140 150 160 170 180 pF1KB7 KDMATGKSKGYGFVSFYNKLDAENAIVHMGGQWLGGRQIRTNWATRKPPAPKSTQENNTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KDMATGKSKGYGFVSFYNKLDAENAIVHMGGQWLGGRQIRTNWATRKPPAPKSTQENNTK 100 110 120 130 140 150 190 200 210 220 230 240 pF1KB7 QLRFEDVVNQSSPKNCTVYCGGIASGLTDQLMRQTFSPFGQIMEIRVFPEKGYSFVRFST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QLRFEDVVNQSSPKNCTVYCGGIASGLTDQLMRQTFSPFGQIMEIRVFPEKGYSFVRFST 160 170 180 190 200 210 250 260 270 280 290 300 pF1KB7 HESAAHAIVSVNGTTIEGHVVKCYWGKESPDMTKNFQQVDYSQWGQWSQVYGNPQQYGQY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HESAAHAIVSVNGTTIEGHVVKCYWGKESPDMTKNFQQVDYSQWGQWSQVYGNPQQYGQY 220 230 240 250 260 270 310 320 330 340 350 360 pF1KB7 MANGWQVPPYGVYGQPWNQQGFGVDQSPSAAWMGGFGAQPPQGQAPPPVIPPPNQAGYGM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MANGWQVPPYGVYGQPWNQQGFGVDQSPSAAWMGGFGAQPPQGQAPPPVIPPPNQAGYGM 280 290 300 310 320 330 370 pF1KB7 ASYQTQ :::::: NP_001 ASYQTQ >>NP_001310899 (OMIM: 603413) nucleolysin TIAR isoform 6 (353 aa) initn: 2341 init1: 2341 opt: 2341 Z-score: 1548.3 bits: 295.1 E(85289): 1.7e-79 Smith-Waterman score: 2341; 99.1% identity (99.7% similar) in 335 aa overlap (41-375:19-353) 20 30 40 50 60 70 pF1KB7 LYVGNLSRDVTEVLILQLFSQIGPCKSCKMITEHTSNDPYCFVEFYEHRDAAAALAAMNG . .::::::::::::::::::::::::::: NP_001 MITEQPDSRRVNSSVGFSVLQHTSNDPYCFVEFYEHRDAAAALAAMNG 10 20 30 40 80 90 100 110 120 130 pF1KB7 RKILGKEVKVNWATTPSSQKKDTSNHFHVFVGDLSPEITTEDIKSAFAPFGKISDARVVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RKILGKEVKVNWATTPSSQKKDTSNHFHVFVGDLSPEITTEDIKSAFAPFGKISDARVVK 50 60 70 80 90 100 140 150 160 170 180 190 pF1KB7 DMATGKSKGYGFVSFYNKLDAENAIVHMGGQWLGGRQIRTNWATRKPPAPKSTQENNTKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DMATGKSKGYGFVSFYNKLDAENAIVHMGGQWLGGRQIRTNWATRKPPAPKSTQENNTKQ 110 120 130 140 150 160 200 210 220 230 240 250 pF1KB7 LRFEDVVNQSSPKNCTVYCGGIASGLTDQLMRQTFSPFGQIMEIRVFPEKGYSFVRFSTH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LRFEDVVNQSSPKNCTVYCGGIASGLTDQLMRQTFSPFGQIMEIRVFPEKGYSFVRFSTH 170 180 190 200 210 220 260 270 280 290 300 310 pF1KB7 ESAAHAIVSVNGTTIEGHVVKCYWGKESPDMTKNFQQVDYSQWGQWSQVYGNPQQYGQYM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ESAAHAIVSVNGTTIEGHVVKCYWGKESPDMTKNFQQVDYSQWGQWSQVYGNPQQYGQYM 230 240 250 260 270 280 320 330 340 350 360 370 pF1KB7 ANGWQVPPYGVYGQPWNQQGFGVDQSPSAAWMGGFGAQPPQGQAPPPVIPPPNQAGYGMA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ANGWQVPPYGVYGQPWNQQGFGVDQSPSAAWMGGFGAQPPQGQAPPPVIPPPNQAGYGMA 290 300 310 320 330 340 pF1KB7 SYQTQ ::::: NP_001 SYQTQ 350 >>NP_001029097 (OMIM: 603413) nucleolysin TIAR isoform 2 (392 aa) initn: 2341 init1: 2341 opt: 2341 Z-score: 1547.8 bits: 295.1 E(85289): 1.8e-79 Smith-Waterman score: 2580; 95.7% identity (95.7% similar) in 392 aa overlap (1-375:1-392) 10 20 30 40 pF1KB7 MMEDDGQPRTLYVGNLSRDVTEVLILQLFSQIGPCKSCKMITE----------------- ::::::::::::::::::::::::::::::::::::::::::: NP_001 MMEDDGQPRTLYVGNLSRDVTEVLILQLFSQIGPCKSCKMITEQPDSRRVNSSVGFSVLQ 10 20 30 40 50 60 50 60 70 80 90 100 pF1KB7 HTSNDPYCFVEFYEHRDAAAALAAMNGRKILGKEVKVNWATTPSSQKKDTSNHFHVFVGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HTSNDPYCFVEFYEHRDAAAALAAMNGRKILGKEVKVNWATTPSSQKKDTSNHFHVFVGD 70 80 90 100 110 120 110 120 130 140 150 160 pF1KB7 LSPEITTEDIKSAFAPFGKISDARVVKDMATGKSKGYGFVSFYNKLDAENAIVHMGGQWL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LSPEITTEDIKSAFAPFGKISDARVVKDMATGKSKGYGFVSFYNKLDAENAIVHMGGQWL 130 140 150 160 170 180 170 180 190 200 210 220 pF1KB7 GGRQIRTNWATRKPPAPKSTQENNTKQLRFEDVVNQSSPKNCTVYCGGIASGLTDQLMRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GGRQIRTNWATRKPPAPKSTQENNTKQLRFEDVVNQSSPKNCTVYCGGIASGLTDQLMRQ 190 200 210 220 230 240 230 240 250 260 270 280 pF1KB7 TFSPFGQIMEIRVFPEKGYSFVRFSTHESAAHAIVSVNGTTIEGHVVKCYWGKESPDMTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TFSPFGQIMEIRVFPEKGYSFVRFSTHESAAHAIVSVNGTTIEGHVVKCYWGKESPDMTK 250 260 270 280 290 300 290 300 310 320 330 340 pF1KB7 NFQQVDYSQWGQWSQVYGNPQQYGQYMANGWQVPPYGVYGQPWNQQGFGVDQSPSAAWMG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NFQQVDYSQWGQWSQVYGNPQQYGQYMANGWQVPPYGVYGQPWNQQGFGVDQSPSAAWMG 310 320 330 340 350 360 350 360 370 pF1KB7 GFGAQPPQGQAPPPVIPPPNQAGYGMASYQTQ :::::::::::::::::::::::::::::::: NP_001 GFGAQPPQGQAPPPVIPPPNQAGYGMASYQTQ 370 380 390 >>NP_001310897 (OMIM: 603413) nucleolysin TIAR isoform 4 (360 aa) initn: 2321 init1: 2028 opt: 2311 Z-score: 1528.6 bits: 291.5 E(85289): 2.1e-78 Smith-Waterman score: 2311; 96.8% identity (97.7% similar) in 342 aa overlap (41-375:19-360) 20 30 40 50 60 70 pF1KB7 LYVGNLSRDVTEVLILQLFSQIGPCKSCKMITEHTSNDPYCFVEFYEHRDAAAALAAMNG . .::::::::::::::::::::::::::: NP_001 MITEQPDSRRVNSSVGFSVLQHTSNDPYCFVEFYEHRDAAAALAAMNG 10 20 30 40 80 90 100 110 120 130 pF1KB7 RKILGKEVKVNWATTPSSQKKDTSNHFHVFVGDLSPEITTEDIKSAFAPFGKISDARVVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RKILGKEVKVNWATTPSSQKKDTSNHFHVFVGDLSPEITTEDIKSAFAPFGKISDARVVK 50 60 70 80 90 100 140 150 160 170 180 190 pF1KB7 DMATGKSKGYGFVSFYNKLDAENAIVHMGGQWLGGRQIRTNWATRKPPAPKSTQENNTKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DMATGKSKGYGFVSFYNKLDAENAIVHMGGQWLGGRQIRTNWATRKPPAPKSTQENNTKQ 110 120 130 140 150 160 200 210 220 230 240 250 pF1KB7 LRFEDVVNQSSPKNCTVYCGGIASGLTDQLMRQTFSPFGQIMEIRVFPEKGYSFVRFSTH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LRFEDVVNQSSPKNCTVYCGGIASGLTDQLMRQTFSPFGQIMEIRVFPEKGYSFVRFSTH 170 180 190 200 210 220 260 270 280 290 300 310 pF1KB7 ESAAHAIVSVNGTTIEGHVVKCYWGKESPDMTKNFQQVDYSQWGQWSQVYGNPQQYGQYM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ESAAHAIVSVNGTTIEGHVVKCYWGKESPDMTKNFQQVDYSQWGQWSQVYGNPQQYGQYM 230 240 250 260 270 280 320 330 340 350 360 pF1KB7 ANGWQVPPYGVYGQPWNQQGFGVD-------QSPSAAWMGGFGAQPPQGQAPPPVIPPPN :::::::::::::::::::::::. ::::::::::::::::::::::::::::: NP_001 ANGWQVPPYGVYGQPWNQQGFGVEFFLFLPSQSPSAAWMGGFGAQPPQGQAPPPVIPPPN 290 300 310 320 330 340 370 pF1KB7 QAGYGMASYQTQ :::::::::::: NP_001 QAGYGMASYQTQ 350 360 >>XP_005264584 (OMIM: 603518,604454) PREDICTED: nucleoly (374 aa) initn: 1977 init1: 1690 opt: 2043 Z-score: 1353.8 bits: 259.2 E(85289): 1.1e-68 Smith-Waterman score: 2043; 79.7% identity (90.2% similar) in 379 aa overlap (2-375:1-374) 10 20 30 40 50 60 pF1KB7 MMEDDGQPRTLYVGNLSRDVTEVLILQLFSQIGPCKSCKMITEHTSNDPYCFVEFYEHRD :::. .:.:::::::::::::.:::::::::::::.:::: . ..:::::::::.::: XP_005 MEDE-MPKTLYVGNLSRDVTEALILQLFSQIGPCKNCKMIMDTAGNDPYCFVEFHEHRH 10 20 30 40 50 70 80 90 100 110 120 pF1KB7 AAAALAAMNGRKILGKEVKVNWATTPSSQKKDTSNHFHVFVGDLSPEITTEDIKSAFAPF :::::::::::::.::::::::::::::::::::::::::::::::::::::::.::::: XP_005 AAAALAAMNGRKIMGKEVKVNWATTPSSQKKDTSNHFHVFVGDLSPEITTEDIKAAFAPF 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB7 GKISDARVVKDMATGKSKGYGFVSFYNKLDAENAIVHMGGQWLGGRQIRTNWATRKPPAP :.:::::::::::::::::::::::.:: :::::: .::::::::::::::::::::::: XP_005 GRISDARVVKDMATGKSKGYGFVSFFNKWDAENAIQQMGGQWLGGRQIRTNWATRKPPAP 120 130 140 150 160 170 190 200 210 220 230 240 pF1KB7 KSTQENNTKQLRFEDVVNQSSPKNCTVYCGGIASGLTDQLMRQTFSPFGQIMEIRVFPEK ::: :.::::: ...:::::::.::::::::..::::.::::::::::::::::::::.: XP_005 KSTYESNTKQLSYDEVVNQSSPSNCTVYCGGVTSGLTEQLMRQTFSPFGQIMEIRVFPDK 180 190 200 210 220 230 250 260 270 280 290 pF1KB7 GYSFVRFSTHESAAHAIVSVNGTTIEGHVVKCYWGKESPDMTKNFQQ--VDYSQ-WGQWS :::::::..::::::::::::::::::::::::::::. :: . :: . : : .:::. XP_005 GYSFVRFNSHESAAHAIVSVNGTTIEGHVVKCYWGKETLDMINPVQQNQIGYPQPYGQWG 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB7 QVYGNPQQYGQYMANGWQVPPYGVYGQPWNQQGFGVDQSPSAAWMG-GFGAQPPQGQAPP : ::: :: :::: :::::: ::.::: ::::::. :: :: ::: ..:.:::::: XP_005 QWYGNAQQIGQYMPNGWQVPAYGMYGQAWNQQGFNQTQS-SAPWMGPNYGVQPPQGQNGS 300 310 320 330 340 350 360 370 pF1KB7 PVIPPPNQ-AGYGMASYQTQ . ::: .:: .:.:.:: XP_005 ML---PNQPSGYRVAGYETQ 360 370 >>NP_071320 (OMIM: 603518,604454) nucleolysin TIA-1 isof (375 aa) initn: 1977 init1: 1690 opt: 2041 Z-score: 1352.5 bits: 258.9 E(85289): 1.4e-68 Smith-Waterman score: 2041; 79.5% identity (90.0% similar) in 380 aa overlap (2-375:1-375) 10 20 30 40 50 60 pF1KB7 MMEDDGQPRTLYVGNLSRDVTEVLILQLFSQIGPCKSCKMITEHTSNDPYCFVEFYEHRD :::. .:.:::::::::::::.:::::::::::::.:::: . ..:::::::::.::: NP_071 MEDE-MPKTLYVGNLSRDVTEALILQLFSQIGPCKNCKMIMDTAGNDPYCFVEFHEHRH 10 20 30 40 50 70 80 90 100 110 120 pF1KB7 AAAALAAMNGRKILGKEVKVNWATTPSSQKKDTSNHFHVFVGDLSPEITTEDIKSAFAPF :::::::::::::.::::::::::::::::::::::::::::::::::::::::.::::: NP_071 AAAALAAMNGRKIMGKEVKVNWATTPSSQKKDTSNHFHVFVGDLSPEITTEDIKAAFAPF 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB7 GKISDARVVKDMATGKSKGYGFVSFYNKLDAENAIVHMGGQWLGGRQIRTNWATRKPPAP :.:::::::::::::::::::::::.:: :::::: .::::::::::::::::::::::: NP_071 GRISDARVVKDMATGKSKGYGFVSFFNKWDAENAIQQMGGQWLGGRQIRTNWATRKPPAP 120 130 140 150 160 170 190 200 210 220 230 240 pF1KB7 KSTQENNTKQLRFEDVVNQSSPKNCTVYCGGIASGLTDQLMRQTFSPFGQIMEIRVFPEK ::: :.::::: ...:::::::.::::::::..::::.::::::::::::::::::::.: NP_071 KSTYESNTKQLSYDEVVNQSSPSNCTVYCGGVTSGLTEQLMRQTFSPFGQIMEIRVFPDK 180 190 200 210 220 230 250 260 270 280 290 pF1KB7 GYSFVRFSTHESAAHAIVSVNGTTIEGHVVKCYWGKESPDMTKNFQQ---VDYSQ-WGQW :::::::..::::::::::::::::::::::::::::. :: . :: . : : .::: NP_071 GYSFVRFNSHESAAHAIVSVNGTTIEGHVVKCYWGKETLDMINPVQQQNQIGYPQPYGQW 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB7 SQVYGNPQQYGQYMANGWQVPPYGVYGQPWNQQGFGVDQSPSAAWMG-GFGAQPPQGQAP .: ::: :: :::: :::::: ::.::: ::::::. :: :: ::: ..:.:::::: NP_071 GQWYGNAQQIGQYMPNGWQVPAYGMYGQAWNQQGFNQTQS-SAPWMGPNYGVQPPQGQNG 300 310 320 330 340 350 360 370 pF1KB7 PPVIPPPNQ-AGYGMASYQTQ . ::: .:: .:.:.:: NP_071 SML---PNQPSGYRVAGYETQ 360 370 >>XP_016860279 (OMIM: 603518,604454) PREDICTED: nucleoly (338 aa) initn: 1769 init1: 1482 opt: 1829 Z-score: 1214.7 bits: 233.3 E(85289): 6.4e-61 Smith-Waterman score: 1829; 78.9% identity (89.2% similar) in 342 aa overlap (40-375:1-338) 10 20 30 40 50 60 pF1KB7 TLYVGNLSRDVTEVLILQLFSQIGPCKSCKMITEHTSNDPYCFVEFYEHRDAAAALAAMN :: . ..:::::::::.::: ::::::::: XP_016 MIMDTAGNDPYCFVEFHEHRHAAAALAAMN 10 20 30 70 80 90 100 110 120 pF1KB7 GRKILGKEVKVNWATTPSSQKKDTSNHFHVFVGDLSPEITTEDIKSAFAPFGKISDARVV ::::.::::::::::::::::::::::::::::::::::::::::.::::::.::::::: XP_016 GRKIMGKEVKVNWATTPSSQKKDTSNHFHVFVGDLSPEITTEDIKAAFAPFGRISDARVV 40 50 60 70 80 90 130 140 150 160 170 180 pF1KB7 KDMATGKSKGYGFVSFYNKLDAENAIVHMGGQWLGGRQIRTNWATRKPPAPKSTQENNTK ::::::::::::::::.:: :::::: .:::::::::::::::::::::::::: :.::: XP_016 KDMATGKSKGYGFVSFFNKWDAENAIQQMGGQWLGGRQIRTNWATRKPPAPKSTYESNTK 100 110 120 130 140 150 190 200 210 220 230 240 pF1KB7 QLRFEDVVNQSSPKNCTVYCGGIASGLTDQLMRQTFSPFGQIMEIRVFPEKGYSFVRFST :: ...:::::::.::::::::..::::.::::::::::::::::::::.::::::::.. XP_016 QLSYDEVVNQSSPSNCTVYCGGVTSGLTEQLMRQTFSPFGQIMEIRVFPDKGYSFVRFNS 160 170 180 190 200 210 250 260 270 280 290 300 pF1KB7 HESAAHAIVSVNGTTIEGHVVKCYWGKESPDMTKNFQQ---VDYSQ-WGQWSQVYGNPQQ ::::::::::::::::::::::::::::. :: . :: . : : .:::.: ::: :: XP_016 HESAAHAIVSVNGTTIEGHVVKCYWGKETLDMINPVQQQNQIGYPQPYGQWGQWYGNAQQ 220 230 240 250 260 270 310 320 330 340 350 360 pF1KB7 YGQYMANGWQVPPYGVYGQPWNQQGFGVDQSPSAAWMG-GFGAQPPQGQAPPPVIPPPNQ :::: :::::: ::.::: ::::::. :: :: ::: ..:.:::::: . ::: XP_016 IGQYMPNGWQVPAYGMYGQAWNQQGFNQTQS-SAPWMGPNYGVQPPQGQNGSML---PNQ 280 290 300 310 320 370 pF1KB7 -AGYGMASYQTQ .:: .:.:.:: XP_016 PSGYRVAGYETQ 330 >>NP_001310896 (OMIM: 603413) nucleolysin TIAR isoform 3 (252 aa) initn: 1794 init1: 1794 opt: 1794 Z-score: 1193.1 bits: 228.9 E(85289): 1e-59 Smith-Waterman score: 1794; 100.0% identity (100.0% similar) in 251 aa overlap (125-375:2-252) 100 110 120 130 140 150 pF1KB7 NHFHVFVGDLSPEITTEDIKSAFAPFGKISDARVVKDMATGKSKGYGFVSFYNKLDAENA :::::::::::::::::::::::::::::: NP_001 MDARVVKDMATGKSKGYGFVSFYNKLDAENA 10 20 30 160 170 180 190 200 210 pF1KB7 IVHMGGQWLGGRQIRTNWATRKPPAPKSTQENNTKQLRFEDVVNQSSPKNCTVYCGGIAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IVHMGGQWLGGRQIRTNWATRKPPAPKSTQENNTKQLRFEDVVNQSSPKNCTVYCGGIAS 40 50 60 70 80 90 220 230 240 250 260 270 pF1KB7 GLTDQLMRQTFSPFGQIMEIRVFPEKGYSFVRFSTHESAAHAIVSVNGTTIEGHVVKCYW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GLTDQLMRQTFSPFGQIMEIRVFPEKGYSFVRFSTHESAAHAIVSVNGTTIEGHVVKCYW 100 110 120 130 140 150 280 290 300 310 320 330 pF1KB7 GKESPDMTKNFQQVDYSQWGQWSQVYGNPQQYGQYMANGWQVPPYGVYGQPWNQQGFGVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GKESPDMTKNFQQVDYSQWGQWSQVYGNPQQYGQYMANGWQVPPYGVYGQPWNQQGFGVD 160 170 180 190 200 210 340 350 360 370 pF1KB7 QSPSAAWMGGFGAQPPQGQAPPPVIPPPNQAGYGMASYQTQ ::::::::::::::::::::::::::::::::::::::::: NP_001 QSPSAAWMGGFGAQPPQGQAPPPVIPPPNQAGYGMASYQTQ 220 230 240 250 >>NP_001310893 (OMIM: 603413) nucleolysin TIAR isoform 3 (252 aa) initn: 1794 init1: 1794 opt: 1794 Z-score: 1193.1 bits: 228.9 E(85289): 1e-59 Smith-Waterman score: 1794; 100.0% identity (100.0% similar) in 251 aa overlap (125-375:2-252) 100 110 120 130 140 150 pF1KB7 NHFHVFVGDLSPEITTEDIKSAFAPFGKISDARVVKDMATGKSKGYGFVSFYNKLDAENA :::::::::::::::::::::::::::::: NP_001 MDARVVKDMATGKSKGYGFVSFYNKLDAENA 10 20 30 160 170 180 190 200 210 pF1KB7 IVHMGGQWLGGRQIRTNWATRKPPAPKSTQENNTKQLRFEDVVNQSSPKNCTVYCGGIAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IVHMGGQWLGGRQIRTNWATRKPPAPKSTQENNTKQLRFEDVVNQSSPKNCTVYCGGIAS 40 50 60 70 80 90 220 230 240 250 260 270 pF1KB7 GLTDQLMRQTFSPFGQIMEIRVFPEKGYSFVRFSTHESAAHAIVSVNGTTIEGHVVKCYW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GLTDQLMRQTFSPFGQIMEIRVFPEKGYSFVRFSTHESAAHAIVSVNGTTIEGHVVKCYW 100 110 120 130 140 150 280 290 300 310 320 330 pF1KB7 GKESPDMTKNFQQVDYSQWGQWSQVYGNPQQYGQYMANGWQVPPYGVYGQPWNQQGFGVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GKESPDMTKNFQQVDYSQWGQWSQVYGNPQQYGQYMANGWQVPPYGVYGQPWNQQGFGVD 160 170 180 190 200 210 340 350 360 370 pF1KB7 QSPSAAWMGGFGAQPPQGQAPPPVIPPPNQAGYGMASYQTQ ::::::::::::::::::::::::::::::::::::::::: NP_001 QSPSAAWMGGFGAQPPQGQAPPPVIPPPNQAGYGMASYQTQ 220 230 240 250 375 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 10:14:36 2016 done: Sat Nov 5 10:14:37 2016 Total Scan time: 8.730 Total Display time: 0.040 Function used was FASTA [36.3.4 Apr, 2011]