FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB7958, 396 aa 1>>>pF1KB7958 396 - 396 aa - 396 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.7591+/-0.000444; mu= 14.5612+/- 0.027 mean_var=119.1035+/-25.680, 0's: 0 Z-trim(111.6): 229 B-trim: 494 in 1/53 Lambda= 0.117520 statistics sampled from 19910 (20219) to 19910 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.606), E-opt: 0.2 (0.237), width: 16 Scan time: 8.230 The best scores are: opt bits E(85289) NP_000073 (OMIM: 216400,609412,614621) DNA excisio ( 396) 2691 468.1 1.6e-131 NP_001007234 (OMIM: 216400,609412,614621) DNA exci ( 338) 2314 404.1 2.6e-112 NP_001277214 (OMIM: 216400,609412,614621) DNA exci ( 243) 1617 285.8 7.7e-77 NP_001007235 (OMIM: 216400,609412,614621) DNA exci ( 205) 1246 222.8 5.9e-58 NP_056441 (OMIM: 610091) WD repeat and SOCS box-co ( 421) 237 52.1 3e-06 NP_599027 (OMIM: 610091) WD repeat and SOCS box-co ( 275) 229 50.5 5.8e-06 XP_016879922 (OMIM: 610091) PREDICTED: WD repeat a ( 383) 212 47.8 5.3e-05 NP_001309195 (OMIM: 607795,615922) U4/U6 small nuc ( 279) 207 46.8 7.7e-05 NP_001309196 (OMIM: 607795,615922) U4/U6 small nuc ( 279) 207 46.8 7.7e-05 NP_001231855 (OMIM: 607795,615922) U4/U6 small nuc ( 521) 207 47.1 0.00012 NP_004688 (OMIM: 607795,615922) U4/U6 small nuclea ( 522) 207 47.1 0.00012 XP_011510137 (OMIM: 612173) PREDICTED: sperm-assoc ( 323) 198 45.3 0.00025 XP_016860390 (OMIM: 612173) PREDICTED: sperm-assoc ( 323) 198 45.3 0.00025 XP_016860391 (OMIM: 612173) PREDICTED: sperm-assoc ( 323) 198 45.3 0.00025 XP_016860389 (OMIM: 612173) PREDICTED: sperm-assoc ( 323) 198 45.3 0.00025 NP_001308124 (OMIM: 270710,602342,608628,616944) F ( 427) 199 45.6 0.00026 XP_016860387 (OMIM: 612173) PREDICTED: sperm-assoc ( 390) 198 45.4 0.00028 XP_006713809 (OMIM: 270710,602342,608628,616944) P ( 514) 199 45.7 0.0003 XP_011511444 (OMIM: 270710,602342,608628,616944) P ( 514) 199 45.7 0.0003 XP_005247832 (OMIM: 270710,602342,608628,616944) P ( 514) 199 45.7 0.0003 NP_001308122 (OMIM: 270710,602342,608628,616944) F ( 514) 199 45.7 0.0003 NP_001308123 (OMIM: 270710,602342,608628,616944) F ( 514) 199 45.7 0.0003 XP_011511443 (OMIM: 270710,602342,608628,616944) P ( 514) 199 45.7 0.0003 NP_078941 (OMIM: 270710,602342,608628,616944) F-bo ( 514) 199 45.7 0.0003 XP_016862674 (OMIM: 270710,602342,608628,616944) P ( 514) 199 45.7 0.0003 XP_011511445 (OMIM: 270710,602342,608628,616944) P ( 514) 199 45.7 0.0003 XP_016860386 (OMIM: 612173) PREDICTED: sperm-assoc ( 512) 198 45.5 0.00034 XP_016860385 (OMIM: 612173) PREDICTED: sperm-assoc ( 512) 198 45.5 0.00034 XP_011510124 (OMIM: 612173) PREDICTED: sperm-assoc ( 528) 198 45.6 0.00034 XP_011510125 (OMIM: 612173) PREDICTED: sperm-assoc ( 528) 198 45.6 0.00034 XP_011510123 (OMIM: 612173) PREDICTED: sperm-assoc ( 537) 198 45.6 0.00035 XP_011509771 (OMIM: 616620) PREDICTED: ribosome bi ( 285) 194 44.6 0.00036 XP_011510121 (OMIM: 612173) PREDICTED: sperm-assoc ( 577) 198 45.6 0.00036 XP_011510116 (OMIM: 612173) PREDICTED: sperm-assoc ( 600) 198 45.6 0.00037 NP_078808 (OMIM: 612173) sperm-associated antigen ( 631) 198 45.6 0.00039 NP_060726 (OMIM: 616620) ribosome biogenesis prote ( 423) 194 44.8 0.00047 NP_001132939 (OMIM: 300196) F-box-like/WD repeat-c ( 526) 189 44.0 0.00099 XP_011543873 (OMIM: 300196) PREDICTED: F-box-like/ ( 526) 189 44.0 0.00099 NP_001132940 (OMIM: 300196) F-box-like/WD repeat-c ( 526) 189 44.0 0.00099 NP_005638 (OMIM: 300196) F-box-like/WD repeat-cont ( 577) 189 44.1 0.001 NP_001132938 (OMIM: 300196) F-box-like/WD repeat-c ( 577) 189 44.1 0.001 XP_016885576 (OMIM: 400033) PREDICTED: F-box-like/ ( 540) 185 43.4 0.0016 XP_016885575 (OMIM: 400033) PREDICTED: F-box-like/ ( 577) 185 43.4 0.0017 XP_011510120 (OMIM: 612173) PREDICTED: sperm-assoc ( 577) 185 43.4 0.0017 XP_011510119 (OMIM: 612173) PREDICTED: sperm-assoc ( 582) 185 43.4 0.0017 XP_011510117 (OMIM: 612173) PREDICTED: sperm-assoc ( 592) 185 43.4 0.0017 XP_011510118 (OMIM: 612173) PREDICTED: sperm-assoc ( 592) 185 43.4 0.0017 NP_150600 (OMIM: 400033) F-box-like/WD repeat-cont ( 522) 181 42.7 0.0025 NP_599021 (OMIM: 400033) F-box-like/WD repeat-cont ( 522) 181 42.7 0.0025 NP_599020 (OMIM: 400033) F-box-like/WD repeat-cont ( 522) 181 42.7 0.0025 >>NP_000073 (OMIM: 216400,609412,614621) DNA excision re (396 aa) initn: 2691 init1: 2691 opt: 2691 Z-score: 2482.1 bits: 468.1 E(85289): 1.6e-131 Smith-Waterman score: 2691; 100.0% identity (100.0% similar) in 396 aa overlap (1-396:1-396) 10 20 30 40 50 60 pF1KB7 MLGFLSARQTGLEDPLRLRRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MLGFLSARQTGLEDPLRLRRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYML 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 SGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 SGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 DKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 DKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSH 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 ILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 ILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 NTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 NTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB7 CGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 CGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILA 310 320 330 340 350 360 370 380 390 pF1KB7 WVPSLYEPVPDDDETTTKSQLNPAFEDAWSSSDEEG :::::::::::::::::::::::::::::::::::: NP_000 WVPSLYEPVPDDDETTTKSQLNPAFEDAWSSSDEEG 370 380 390 >>NP_001007234 (OMIM: 216400,609412,614621) DNA excision (338 aa) initn: 2314 init1: 2314 opt: 2314 Z-score: 2137.5 bits: 404.1 E(85289): 2.6e-112 Smith-Waterman score: 2314; 100.0% identity (100.0% similar) in 338 aa overlap (59-396:1-338) 30 40 50 60 70 80 pF1KB7 GLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVC :::::::::::::::::::::::::::::: NP_001 MLSGGSDGVIVLYDLENSSRQSYYTCKAVC 10 20 30 90 100 110 120 130 140 pF1KB7 SIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHH 40 50 60 70 80 90 150 160 170 180 190 200 pF1KB7 MSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASAD 100 110 120 130 140 150 210 220 230 240 250 260 pF1KB7 SRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNR 160 170 180 190 200 210 270 280 290 300 310 320 pF1KB7 MRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQIT 220 230 240 250 260 270 330 340 350 360 370 380 pF1KB7 MLKGHYKTVDCCVFQSNFQELYSGSRDCNILAWVPSLYEPVPDDDETTTKSQLNPAFEDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MLKGHYKTVDCCVFQSNFQELYSGSRDCNILAWVPSLYEPVPDDDETTTKSQLNPAFEDA 280 290 300 310 320 330 390 pF1KB7 WSSSDEEG :::::::: NP_001 WSSSDEEG >>NP_001277214 (OMIM: 216400,609412,614621) DNA excision (243 aa) initn: 1617 init1: 1617 opt: 1617 Z-score: 1500.6 bits: 285.8 E(85289): 7.7e-77 Smith-Waterman score: 1617; 98.7% identity (100.0% similar) in 238 aa overlap (159-396:6-243) 130 140 150 160 170 180 pF1KB7 TNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQE ...::::::::::::::::::::::::::: NP_001 MGYKYITIGTRGPKVQLCDLKSGSCSHILQGHRQE 10 20 30 190 200 210 220 230 240 pF1KB7 ILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKV 40 50 60 70 80 90 250 260 270 280 290 300 pF1KB7 NGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFV 100 110 120 130 140 150 310 320 330 340 350 360 pF1KB7 FVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAWVPSLYEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAWVPSLYEP 160 170 180 190 200 210 370 380 390 pF1KB7 VPDDDETTTKSQLNPAFEDAWSSSDEEG :::::::::::::::::::::::::::: NP_001 VPDDDETTTKSQLNPAFEDAWSSSDEEG 220 230 240 >>NP_001007235 (OMIM: 216400,609412,614621) DNA excision (205 aa) initn: 1246 init1: 1246 opt: 1246 Z-score: 1161.5 bits: 222.8 E(85289): 5.9e-58 Smith-Waterman score: 1246; 100.0% identity (100.0% similar) in 184 aa overlap (1-184:1-184) 10 20 30 40 50 60 pF1KB7 MLGFLSARQTGLEDPLRLRRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MLGFLSARQTGLEDPLRLRRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYML 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 SGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 DKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSH 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 ILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESA :::: NP_001 ILQGIFILFQTATTLSKRFNKKKRY 190 200 >>NP_056441 (OMIM: 610091) WD repeat and SOCS box-contai (421 aa) initn: 216 init1: 75 opt: 237 Z-score: 233.2 bits: 52.1 E(85289): 3e-06 Smith-Waterman score: 237; 28.7% identity (59.7% similar) in 216 aa overlap (63-272:137-338) 40 50 60 70 80 90 pF1KB7 NKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSY--YTCKAVCSI :.: ... :.:. . . :: : . .. NP_056 GDIVWSLAFGSSVPEKQSRCVNIEWHRFRFGQDQLLLATGLNNGRIKIWDVYTGKLLLNL 110 120 130 140 150 160 100 110 120 130 140 pF1KB7 GRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDT----NTLQTADVFNFEETVYS :: .: :. . . : . ...:.: ::::.::: : ... . . .. ::: NP_056 -VDHTEV----VRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKV--LRGHQNWVYS 170 180 190 200 210 150 160 170 180 190 200 pF1KB7 HHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATAS .:: :. : .::. . : : .. . . . :.::.....: ..:: .::::: NP_056 CAFSPDSSMLC--SVGA-SKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPD-GALLATAS 220 230 240 250 260 270 210 220 230 240 250 260 pF1KB7 ADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTD :.:: .:: . .: .. : . :. :.. : .. :. ::::. ... : NP_056 YDTRVYIWDPH--NGDILMEFGHLFPPPTPIF-AGGANDRWVRSVSFSHDGLHVASLADD 280 290 300 310 320 330 270 280 290 300 310 320 pF1KB7 NRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQ . .:.: NP_056 KMVRFWRIDEDYPVQVAPLSNGLCCAFSTDGSVLAAGTHDGSVYFWATPRQVPSLQHLCR 340 350 360 370 380 390 >>NP_599027 (OMIM: 610091) WD repeat and SOCS box-contai (275 aa) initn: 218 init1: 75 opt: 229 Z-score: 228.1 bits: 50.5 E(85289): 5.8e-06 Smith-Waterman score: 229; 29.9% identity (60.3% similar) in 184 aa overlap (93-272:22-192) 70 80 90 100 110 120 pF1KB7 GSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDK :: .: :. . . : . ...:.: :: NP_599 MASFPPRVNEKEIGKLLLNLVDHTEV----VRDLTFAPDGSLILVSASRDK 10 20 30 40 130 140 150 160 170 pF1KB7 TLKVWDT----NTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSC ::.::: : ... . . .. ::: .:: :. : .::. . : : .. . . NP_599 TLRVWDLKDDGNMMKV--LRGHQNWVYSCAFSPDSSMLC--SVGA-SKAVFLWNMDKYTM 50 60 70 80 90 100 180 190 200 210 220 230 pF1KB7 SHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVE . :.::.....: ..:: .::::: :.:: .:: . .: .. : . NP_599 IRKLEGHHHDVVACDFSPD-GALLATASYDTRVYIWDPH--NGDILMEFGHLFPPPTPIF 110 120 130 140 150 240 250 260 270 280 290 pF1KB7 SANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFT :. :.. : .. :. ::::. ... :. .:.: NP_599 -AGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQVAPLSNGLCCAFSTDGS 160 170 180 190 200 210 300 310 320 330 340 350 pF1KB7 VSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNI NP_599 VLAAGTHDGSVYFWATPRQVPSLQHLCRMSIRRVMPTQEVQELPIPSKLLEFLSYRI 220 230 240 250 260 270 >>XP_016879922 (OMIM: 610091) PREDICTED: WD repeat and S (383 aa) initn: 168 init1: 75 opt: 212 Z-score: 210.7 bits: 47.8 E(85289): 5.3e-05 Smith-Waterman score: 212; 28.5% identity (58.8% similar) in 221 aa overlap (63-274:137-342) 40 50 60 70 80 90 pF1KB7 NKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSY--YTCKAVCSI :.: ... :.:. . . :: : . .. XP_016 GDIVWSLAFGSSVPEKQSRCVNIEWHRFRFGQDQLLLATGLNNGRIKIWDVYTGKLLLNL 110 120 130 140 150 160 100 110 120 130 140 pF1KB7 GRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDT----NTLQTADVFNFEETVYS :: .: :. . . : . ...:.: ::::.::: : ... . . .. ::: XP_016 -VDHTEV----VRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKV--LRGHQNWVYS 170 180 190 200 210 150 160 170 180 190 200 pF1KB7 HHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATAS .:: :. : .::. . : : .. . . . :.::.....: ..:: .::::: XP_016 CAFSPDSSMLC--SVGA-SKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPD-GALLATAS 220 230 240 250 260 270 210 220 230 240 250 260 pF1KB7 ADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLC--FTSDGLHLLTVG :.:: .:: . .. : .. . . :. . :::: :..:: .:..: XP_016 YDTRVYIWDPHNGD---ILMEFGMVRFWRIDEDYPVQVAPLSNGLCCAFSTDG-SVLAAG 280 290 300 310 320 330 270 280 290 300 310 320 pF1KB7 T-DNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYS : :. . .: . XP_016 THDGSVYFWATPRQVPSLQHLCRMSIRRVMPTQEVQELPIPSKLLEFLSYRI 340 350 360 370 380 >>NP_001309195 (OMIM: 607795,615922) U4/U6 small nuclear (279 aa) initn: 207 init1: 89 opt: 207 Z-score: 207.8 bits: 46.8 E(85289): 7.7e-05 Smith-Waterman score: 235; 27.9% identity (54.8% similar) in 219 aa overlap (89-272:66-276) 60 70 80 90 100 110 pF1KB7 MLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHP--DV--HRYSVETVQWYPHDTGM :. :.: :. : : :.:.: .: NP_001 IVFHPKSTVSLDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHP--SGR 40 50 60 70 80 90 120 130 140 150 160 170 pF1KB7 FTSSS-FDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKV--QLC : ... .:.. ..:: :.. . . .: .: . .. .. .:: : . .. NP_001 FLGTTCYDRSWRLWD---LEAQEEILHQEG-HSMGVYDIAFHQDGSLAGTGGLDAFGRVW 100 110 120 130 140 180 190 200 210 220 230 pF1KB7 DLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHN- ::..: : .:.:: .:: ....:: : .::.:.:. :.::.:. :. :. :. NP_001 DLRTGRCIMFLEGHLKEIYGINFSPN-GYHIATGSGDNTCKVWDLRQRR-CVYTIPAHQN 150 160 170 180 190 200 240 250 260 pF1KB7 ---GKKSQAVESA--------NTA----------------HNGKVNGLCFTSDGLHLLTV : : . ... ::: :.::: :: ..::: . : NP_001 LVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATC 210 220 230 240 250 260 270 280 290 300 310 320 pF1KB7 GTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYS . : ..:: NP_001 SYDRTFKLWMAE 270 >>NP_001309196 (OMIM: 607795,615922) U4/U6 small nuclear (279 aa) initn: 207 init1: 89 opt: 207 Z-score: 207.8 bits: 46.8 E(85289): 7.7e-05 Smith-Waterman score: 235; 27.9% identity (54.8% similar) in 219 aa overlap (89-272:66-276) 60 70 80 90 100 110 pF1KB7 MLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHP--DV--HRYSVETVQWYPHDTGM :. :.: :. : : :.:.: .: NP_001 IVFHPKSTVSLDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHP--SGR 40 50 60 70 80 90 120 130 140 150 160 170 pF1KB7 FTSSS-FDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKV--QLC : ... .:.. ..:: :.. . . .: .: . .. .. .:: : . .. NP_001 FLGTTCYDRSWRLWD---LEAQEEILHQEG-HSMGVYDIAFHQDGSLAGTGGLDAFGRVW 100 110 120 130 140 180 190 200 210 220 230 pF1KB7 DLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHN- ::..: : .:.:: .:: ....:: : .::.:.:. :.::.:. :. :. :. NP_001 DLRTGRCIMFLEGHLKEIYGINFSPN-GYHIATGSGDNTCKVWDLRQRR-CVYTIPAHQN 150 160 170 180 190 200 240 250 260 pF1KB7 ---GKKSQAVESA--------NTA----------------HNGKVNGLCFTSDGLHLLTV : : . ... ::: :.::: :: ..::: . : NP_001 LVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATC 210 220 230 240 250 260 270 280 290 300 310 320 pF1KB7 GTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYS . : ..:: NP_001 SYDRTFKLWMAE 270 >>NP_001231855 (OMIM: 607795,615922) U4/U6 small nuclear (521 aa) initn: 207 init1: 89 opt: 207 Z-score: 204.5 bits: 47.1 E(85289): 0.00012 Smith-Waterman score: 235; 27.9% identity (54.8% similar) in 219 aa overlap (89-272:308-518) 60 70 80 90 100 110 pF1KB7 MLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHP--DV--HRYSVETVQWYPHDTGM :. :.: :. : : :.:.: .: NP_001 IVFHPKSTVSLDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHP--SGR 280 290 300 310 320 330 120 130 140 150 160 170 pF1KB7 FTSSS-FDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKV--QLC : ... .:.. ..:: :.. . . .: .: . .. .. .:: : . .. NP_001 FLGTTCYDRSWRLWD---LEAQEEILHQEG-HSMGVYDIAFHQDGSLAGTGGLDAFGRVW 340 350 360 370 380 390 180 190 200 210 220 230 pF1KB7 DLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHN- ::..: : .:.:: .:: ....:: : .::.:.:. :.::.:. :. :. :. NP_001 DLRTGRCIMFLEGHLKEIYGINFSPN-GYHIATGSGDNTCKVWDLRQRR-CVYTIPAHQN 400 410 420 430 440 240 250 260 pF1KB7 ---GKKSQAVESA--------NTA----------------HNGKVNGLCFTSDGLHLLTV : : . ... ::: :.::: :: ..::: . : NP_001 LVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATC 450 460 470 480 490 500 270 280 290 300 310 320 pF1KB7 GTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYS . : ..:: NP_001 SYDRTFKLWMAE 510 520 396 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 14:45:32 2016 done: Sat Nov 5 14:45:33 2016 Total Scan time: 8.230 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]