FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB7973, 214 aa 1>>>pF1KB7973 214 - 214 aa - 214 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.4976+/-0.000366; mu= 9.2724+/- 0.023 mean_var=124.3826+/-24.919, 0's: 0 Z-trim(116.8): 76 B-trim: 1283 in 1/50 Lambda= 0.114999 statistics sampled from 28250 (28332) to 28250 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.706), E-opt: 0.2 (0.332), width: 16 Scan time: 6.050 The best scores are: opt bits E(85289) NP_937848 (OMIM: 602976) max-like protein X isofor ( 214) 1422 246.5 2.4e-65 XP_016880480 (OMIM: 602976) PREDICTED: max-like pr ( 268) 1322 230.0 2.8e-60 NP_937847 (OMIM: 602976) max-like protein X isofor ( 244) 1237 215.9 4.7e-56 NP_733752 (OMIM: 602976) max-like protein X isofor ( 298) 1237 215.9 5.4e-56 XP_006719355 (OMIM: 608090) PREDICTED: MLX-interac ( 920) 229 49.1 2.8e-05 NP_055753 (OMIM: 608090) MLX-interacting protein [ ( 919) 224 48.3 4.9e-05 XP_006719357 (OMIM: 608090) PREDICTED: MLX-interac ( 567) 204 44.8 0.00034 XP_006719353 (OMIM: 608090) PREDICTED: MLX-interac ( 960) 204 45.0 0.00051 XP_006719354 (OMIM: 608090) PREDICTED: MLX-interac ( 959) 199 44.1 0.0009 >>NP_937848 (OMIM: 602976) max-like protein X isoform al (214 aa) initn: 1422 init1: 1422 opt: 1422 Z-score: 1294.0 bits: 246.5 E(85289): 2.4e-65 Smith-Waterman score: 1422; 100.0% identity (100.0% similar) in 214 aa overlap (1-214:1-214) 10 20 30 40 50 60 pF1KB7 MTEPGASPEDPWVKVEYAYSDNSLDPDDEDSDYHQEAYKESYKDRRRRAHTQAEQKRRDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_937 MTEPGASPEDPWVKVEYAYSDNSLDPDDEDSDYHQEAYKESYKDRRRRAHTQAEQKRRDA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 IKRGYDDLQTIVPTCQQQDFSIGSQKLSKAIVLQKTIDYIQFLHKEKKKQEEEVSTLRKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_937 IKRGYDDLQTIVPTCQQQDFSIGSQKLSKAIVLQKTIDYIQFLHKEKKKQEEEVSTLRKD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 VTALKIMKVNYEQIVKAHQDNPHEGEDQVSDQVKFNVFQGIMDSLFQSFNASISVASFQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_937 VTALKIMKVNYEQIVKAHQDNPHEGEDQVSDQVKFNVFQGIMDSLFQSFNASISVASFQE 130 140 150 160 170 180 190 200 210 pF1KB7 LSACVFSWIEEHCKPQTLREIVIGVLHQLKNQLY :::::::::::::::::::::::::::::::::: NP_937 LSACVFSWIEEHCKPQTLREIVIGVLHQLKNQLY 190 200 210 >>XP_016880480 (OMIM: 602976) PREDICTED: max-like protei (268 aa) initn: 1322 init1: 1322 opt: 1322 Z-score: 1203.1 bits: 230.0 E(85289): 2.8e-60 Smith-Waterman score: 1322; 100.0% identity (100.0% similar) in 201 aa overlap (14-214:68-268) 10 20 30 40 pF1KB7 MTEPGASPEDPWVKVEYAYSDNSLDPDDEDSDYHQEAYKESYK :::::::::::::::::::::::::::::: XP_016 RRGASLLSPKSPTLSVPRGCREDSSHPACAKVEYAYSDNSLDPDDEDSDYHQEAYKESYK 40 50 60 70 80 90 50 60 70 80 90 100 pF1KB7 DRRRRAHTQAEQKRRDAIKRGYDDLQTIVPTCQQQDFSIGSQKLSKAIVLQKTIDYIQFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DRRRRAHTQAEQKRRDAIKRGYDDLQTIVPTCQQQDFSIGSQKLSKAIVLQKTIDYIQFL 100 110 120 130 140 150 110 120 130 140 150 160 pF1KB7 HKEKKKQEEEVSTLRKDVTALKIMKVNYEQIVKAHQDNPHEGEDQVSDQVKFNVFQGIMD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HKEKKKQEEEVSTLRKDVTALKIMKVNYEQIVKAHQDNPHEGEDQVSDQVKFNVFQGIMD 160 170 180 190 200 210 170 180 190 200 210 pF1KB7 SLFQSFNASISVASFQELSACVFSWIEEHCKPQTLREIVIGVLHQLKNQLY ::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SLFQSFNASISVASFQELSACVFSWIEEHCKPQTLREIVIGVLHQLKNQLY 220 230 240 250 260 >>NP_937847 (OMIM: 602976) max-like protein X isoform be (244 aa) initn: 1237 init1: 1237 opt: 1237 Z-score: 1127.4 bits: 215.9 E(85289): 4.7e-56 Smith-Waterman score: 1352; 87.7% identity (87.7% similar) in 244 aa overlap (1-214:1-244) 10 20 30 pF1KB7 MTEPGASPEDPWVKVEYAYSDNSLDP------------------------------DDED :::::::::::::::::::::::::: :::: NP_937 MTEPGASPEDPWVKVEYAYSDNSLDPGLFVESTRKGSVVSRANSIGSTSASSVPNTDDED 10 20 30 40 50 60 40 50 60 70 80 90 pF1KB7 SDYHQEAYKESYKDRRRRAHTQAEQKRRDAIKRGYDDLQTIVPTCQQQDFSIGSQKLSKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_937 SDYHQEAYKESYKDRRRRAHTQAEQKRRDAIKRGYDDLQTIVPTCQQQDFSIGSQKLSKA 70 80 90 100 110 120 100 110 120 130 140 150 pF1KB7 IVLQKTIDYIQFLHKEKKKQEEEVSTLRKDVTALKIMKVNYEQIVKAHQDNPHEGEDQVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_937 IVLQKTIDYIQFLHKEKKKQEEEVSTLRKDVTALKIMKVNYEQIVKAHQDNPHEGEDQVS 130 140 150 160 170 180 160 170 180 190 200 210 pF1KB7 DQVKFNVFQGIMDSLFQSFNASISVASFQELSACVFSWIEEHCKPQTLREIVIGVLHQLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_937 DQVKFNVFQGIMDSLFQSFNASISVASFQELSACVFSWIEEHCKPQTLREIVIGVLHQLK 190 200 210 220 230 240 pF1KB7 NQLY :::: NP_937 NQLY >>NP_733752 (OMIM: 602976) max-like protein X isoform ga (298 aa) initn: 1329 init1: 1237 opt: 1237 Z-score: 1126.2 bits: 215.9 E(85289): 5.4e-56 Smith-Waterman score: 1252; 87.0% identity (87.0% similar) in 231 aa overlap (14-214:68-298) 10 20 pF1KB7 MTEPGASPEDPWVKVEYAYSDNSLDP----------------- ::::::::::::: NP_733 RRGASLLSPKSPTLSVPRGCREDSSHPACAKVEYAYSDNSLDPGLFVESTRKGSVVSRAN 40 50 60 70 80 90 30 40 50 60 70 pF1KB7 -------------DDEDSDYHQEAYKESYKDRRRRAHTQAEQKRRDAIKRGYDDLQTIVP ::::::::::::::::::::::::::::::::::::::::::::::: NP_733 SIGSTSASSVPNTDDEDSDYHQEAYKESYKDRRRRAHTQAEQKRRDAIKRGYDDLQTIVP 100 110 120 130 140 150 80 90 100 110 120 130 pF1KB7 TCQQQDFSIGSQKLSKAIVLQKTIDYIQFLHKEKKKQEEEVSTLRKDVTALKIMKVNYEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_733 TCQQQDFSIGSQKLSKAIVLQKTIDYIQFLHKEKKKQEEEVSTLRKDVTALKIMKVNYEQ 160 170 180 190 200 210 140 150 160 170 180 190 pF1KB7 IVKAHQDNPHEGEDQVSDQVKFNVFQGIMDSLFQSFNASISVASFQELSACVFSWIEEHC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_733 IVKAHQDNPHEGEDQVSDQVKFNVFQGIMDSLFQSFNASISVASFQELSACVFSWIEEHC 220 230 240 250 260 270 200 210 pF1KB7 KPQTLREIVIGVLHQLKNQLY ::::::::::::::::::::: NP_733 KPQTLREIVIGVLHQLKNQLY 280 290 >>XP_006719355 (OMIM: 608090) PREDICTED: MLX-interacting (920 aa) initn: 360 init1: 155 opt: 229 Z-score: 215.9 bits: 49.1 E(85289): 2.8e-05 Smith-Waterman score: 289; 29.9% identity (62.3% similar) in 204 aa overlap (20-209:695-889) 10 20 30 40 pF1KB7 MTEPGASPEDPWVKVEYAYSDNSLDPDDEDSDYHQEAYKESYKDRRRRA : . .:... : . . :. :. XP_006 LHGGSPQVTVTGPSRDCPNSGQASPCASEQSPSPQSPQNNCSGKSDPKNVAALKQNRQMK 670 680 690 700 710 720 50 60 70 80 90 100 pF1KB7 HTQAEQKRRDAIKRGYDDLQTIVPTCQQQDFSIGSQKLSKAIVLQKTIDYIQFLHKEKKK : .:::::: :: .: :.... : .:. :.::.::::..:: :..:. . XP_006 HISAEQKRRFNIKMCFDMLNSLI--------SNNSKLTSHAITLQKTVEYITKLQQERGQ 730 740 750 760 770 110 120 130 140 150 pF1KB7 QEEEVSTLRKDVTALKIMKVNYEQIVKA------HQDNPHEGEDQVSDQVK--------F ..::. ::... :. .. .:.. : ... : .:. .. :: : XP_006 MQEEARRLREEIEELNATIISCQQLLPATGVPVTRRQFDHM-KDMFDEYVKTRTLQNWKF 780 790 800 810 820 830 160 170 180 190 200 210 pF1KB7 NVFQGIMDSLFQSFNASISVASFQELSACVFSWIEEHCKPQTLREIVIGVLHQLKNQLY .:. :. ::.::.. .:..:..:: ..::...::. :: .:...:.:: XP_006 WIFSIIIKPLFESFKGMVSTSSLEELHRTALSWLDQHCSLPILRPMVLSTLRQLSTSTSI 840 850 860 870 880 890 XP_006 LTDPAQLPEQASKAVTRIGKRLGES 900 910 920 >>NP_055753 (OMIM: 608090) MLX-interacting protein [Homo (919 aa) initn: 355 init1: 155 opt: 224 Z-score: 211.4 bits: 48.3 E(85289): 4.9e-05 Smith-Waterman score: 284; 29.9% identity (62.7% similar) in 204 aa overlap (20-209:695-888) 10 20 30 40 pF1KB7 MTEPGASPEDPWVKVEYAYSDNSLDPDDEDSDYHQEAYKESYKDRRRRA : . .:... : . . :.:. . NP_055 LHGGSPQVTVTGPSRDCPNSGQASPCASEQSPSPQSPQNNCSGKSDPKNVAALKNRQMK- 670 680 690 700 710 720 50 60 70 80 90 100 pF1KB7 HTQAEQKRRDAIKRGYDDLQTIVPTCQQQDFSIGSQKLSKAIVLQKTIDYIQFLHKEKKK : .:::::: :: .: :.... : .:. :.::.::::..:: :..:. . NP_055 HISAEQKRRFNIKMCFDMLNSLI--------SNNSKLTSHAITLQKTVEYITKLQQERGQ 730 740 750 760 770 110 120 130 140 150 pF1KB7 QEEEVSTLRKDVTALKIMKVNYEQIVKA------HQDNPHEGEDQVSDQVK--------F ..::. ::... :. .. .:.. : ... : .:. .. :: : NP_055 MQEEARRLREEIEELNATIISCQQLLPATGVPVTRRQFDHM-KDMFDEYVKTRTLQNWKF 780 790 800 810 820 830 160 170 180 190 200 210 pF1KB7 NVFQGIMDSLFQSFNASISVASFQELSACVFSWIEEHCKPQTLREIVIGVLHQLKNQLY .:. :. ::.::.. .:..:..:: ..::...::. :: .:...:.:: NP_055 WIFSIIIKPLFESFKGMVSTSSLEELHRTALSWLDQHCSLPILRPMVLSTLRQLSTSTSI 840 850 860 870 880 890 NP_055 LTDPAQLPEQASKAVTRIGKRLGES 900 910 >>XP_006719357 (OMIM: 608090) PREDICTED: MLX-interacting (567 aa) initn: 301 init1: 130 opt: 204 Z-score: 196.3 bits: 44.8 E(85289): 0.00034 Smith-Waterman score: 264; 29.4% identity (60.8% similar) in 194 aa overlap (20-199:302-486) 10 20 30 40 pF1KB7 MTEPGASPEDPWVKVEYAYSDNSLDPDDEDSDYHQEAYKESYKDRRRRA : . .:... : . . :. :. XP_006 LHGGSPQVTVTGPSRDCPNSGQASPCASEQSPSPQSPQNNCSGKSDPKNVAALKQNRQMK 280 290 300 310 320 330 50 60 70 80 90 100 pF1KB7 HTQAEQKRRDAIKRGYDDLQTIVPTCQQQDFSIGSQKLSKAIVLQKTIDYIQFLHKEKKK : .:::::: :: .: :.... : .:. :.::.::::..:: :..:. . XP_006 HISAEQKRRFNIKMCFDMLNSLI--------SNNSKLTSHAITLQKTVEYITKLQQERGQ 340 350 360 370 380 110 120 130 140 150 pF1KB7 QEEEVSTLRKDVTALKIMKVNYEQIVKA------HQDNPHEGEDQVSDQVK--------F ..::. ::... :. .. .:.. : ... : .:. .. :: : XP_006 MQEEARRLREEIEELNATIISCQQLLPATGVPVTRRQFDHM-KDMFDEYVKTRTLQNWKF 390 400 410 420 430 440 160 170 180 190 200 210 pF1KB7 NVFQGIMDSLFQSFNASISVASFQELSACVFSWIEEHCKPQTLREIVIGVLHQLKNQLY .:. :. ::.::.. .:..:..:: ..::...::. :: XP_006 WIFSIIIKPLFESFKGMVSTSSLEELHRTALSWLDQHCSLPILRPSYRSLISEQLAAPWH 450 460 470 480 490 500 XP_006 QEQHRMLHLRQLLDLGRLLEAEGGIEHAAAAEHLHLHPHRPGTAARAGVQGCHQDWQEIG 510 520 530 540 550 560 >>XP_006719353 (OMIM: 608090) PREDICTED: MLX-interacting (960 aa) initn: 335 init1: 130 opt: 204 Z-score: 193.2 bits: 45.0 E(85289): 0.00051 Smith-Waterman score: 264; 29.4% identity (60.8% similar) in 194 aa overlap (20-199:695-879) 10 20 30 40 pF1KB7 MTEPGASPEDPWVKVEYAYSDNSLDPDDEDSDYHQEAYKESYKDRRRRA : . .:... : . . :. :. XP_006 LHGGSPQVTVTGPSRDCPNSGQASPCASEQSPSPQSPQNNCSGKSDPKNVAALKQNRQMK 670 680 690 700 710 720 50 60 70 80 90 100 pF1KB7 HTQAEQKRRDAIKRGYDDLQTIVPTCQQQDFSIGSQKLSKAIVLQKTIDYIQFLHKEKKK : .:::::: :: .: :.... : .:. :.::.::::..:: :..:. . XP_006 HISAEQKRRFNIKMCFDMLNSLI--------SNNSKLTSHAITLQKTVEYITKLQQERGQ 730 740 750 760 770 110 120 130 140 150 pF1KB7 QEEEVSTLRKDVTALKIMKVNYEQIVKA------HQDNPHEGEDQVSDQVK--------F ..::. ::... :. .. .:.. : ... : .:. .. :: : XP_006 MQEEARRLREEIEELNATIISCQQLLPATGVPVTRRQFDHM-KDMFDEYVKTRTLQNWKF 780 790 800 810 820 830 160 170 180 190 200 210 pF1KB7 NVFQGIMDSLFQSFNASISVASFQELSACVFSWIEEHCKPQTLREIVIGVLHQLKNQLY .:. :. ::.::.. .:..:..:: ..::...::. :: XP_006 WIFSIIIKPLFESFKGMVSTSSLEELHRTALSWLDQHCSLPILRPSYRSLISEQLAAPWH 840 850 860 870 880 890 XP_006 QEQHRMLHLRQLLDLGRLLEAEGGIEHAAAAEHLHLHPHRPGTAARAGVQGCHQDWQEIG 900 910 920 930 940 950 >>XP_006719354 (OMIM: 608090) PREDICTED: MLX-interacting (959 aa) initn: 330 init1: 130 opt: 199 Z-score: 188.7 bits: 44.1 E(85289): 0.0009 Smith-Waterman score: 259; 29.4% identity (61.3% similar) in 194 aa overlap (20-199:695-878) 10 20 30 40 pF1KB7 MTEPGASPEDPWVKVEYAYSDNSLDPDDEDSDYHQEAYKESYKDRRRRA : . .:... : . . :.:. . XP_006 LHGGSPQVTVTGPSRDCPNSGQASPCASEQSPSPQSPQNNCSGKSDPKNVAALKNRQMK- 670 680 690 700 710 720 50 60 70 80 90 100 pF1KB7 HTQAEQKRRDAIKRGYDDLQTIVPTCQQQDFSIGSQKLSKAIVLQKTIDYIQFLHKEKKK : .:::::: :: .: :.... : .:. :.::.::::..:: :..:. . XP_006 HISAEQKRRFNIKMCFDMLNSLI--------SNNSKLTSHAITLQKTVEYITKLQQERGQ 730 740 750 760 770 110 120 130 140 150 pF1KB7 QEEEVSTLRKDVTALKIMKVNYEQIVKA------HQDNPHEGEDQVSDQVK--------F ..::. ::... :. .. .:.. : ... : .:. .. :: : XP_006 MQEEARRLREEIEELNATIISCQQLLPATGVPVTRRQFDHM-KDMFDEYVKTRTLQNWKF 780 790 800 810 820 830 160 170 180 190 200 210 pF1KB7 NVFQGIMDSLFQSFNASISVASFQELSACVFSWIEEHCKPQTLREIVIGVLHQLKNQLY .:. :. ::.::.. .:..:..:: ..::...::. :: XP_006 WIFSIIIKPLFESFKGMVSTSSLEELHRTALSWLDQHCSLPILRPSYRSLISEQLAAPWH 840 850 860 870 880 890 XP_006 QEQHRMLHLRQLLDLGRLLEAEGGIEHAAAAEHLHLHPHRPGTAARAGVQGCHQDWQEIG 900 910 920 930 940 950 214 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 14:47:58 2016 done: Sat Nov 5 14:47:59 2016 Total Scan time: 6.050 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]