FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB7985, 431 aa 1>>>pF1KB7985 431 - 431 aa - 431 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 10.0312+/-0.000401; mu= -4.6248+/- 0.025 mean_var=249.1894+/-51.791, 0's: 0 Z-trim(120.5): 25 B-trim: 368 in 2/53 Lambda= 0.081247 statistics sampled from 35751 (35776) to 35751 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.755), E-opt: 0.2 (0.419), width: 16 Scan time: 9.550 The best scores are: opt bits E(85289) NP_001027451 (OMIM: 107580,113620) transcription f ( 431) 2929 356.3 8.6e-98 NP_001035890 (OMIM: 107580,113620) transcription f ( 433) 2872 349.6 8.9e-96 NP_003211 (OMIM: 107580,113620) transcription fact ( 437) 2872 349.6 9e-96 XP_006715238 (OMIM: 107580,113620) PREDICTED: tran ( 482) 2872 349.7 9.7e-96 XP_016866721 (OMIM: 107580,113620) PREDICTED: tran ( 519) 2872 349.7 1e-95 XP_011513135 (OMIM: 107580,113620) PREDICTED: tran ( 387) 2384 292.4 1.3e-78 XP_011513139 (OMIM: 169100,601601,617035) PREDICTE ( 469) 2046 252.8 1.3e-66 XP_016866723 (OMIM: 169100,601601,617035) PREDICTE ( 503) 2046 252.9 1.4e-66 XP_016866722 (OMIM: 169100,601601,617035) PREDICTE ( 515) 2046 252.9 1.4e-66 NP_003212 (OMIM: 169100,601601,617035) transcripti ( 460) 2000 247.4 5.5e-65 NP_848643 (OMIM: 614428) transcription factor AP-2 ( 442) 1539 193.4 9.8e-49 NP_003213 (OMIM: 601602) transcription factor AP-2 ( 450) 1468 185.1 3.2e-46 XP_016866724 (OMIM: 169100,601601,617035) PREDICTE ( 307) 1405 177.6 3.9e-44 NP_758438 (OMIM: 610161) transcription factor AP-2 ( 452) 1181 151.4 4.3e-36 XP_016856628 (OMIM: 614428) PREDICTED: transcripti ( 356) 1082 139.8 1.1e-32 >>NP_001027451 (OMIM: 107580,113620) transcription facto (431 aa) initn: 2929 init1: 2929 opt: 2929 Z-score: 1876.6 bits: 356.3 E(85289): 8.6e-98 Smith-Waterman score: 2929; 100.0% identity (100.0% similar) in 431 aa overlap (1-431:1-431) 10 20 30 40 50 60 pF1KB7 MLVHSFSAMDRHDGTSNGTARLPQLGTVGQSPYTSAPPLSHTPNADFQPPYFPPPYQPIY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MLVHSFSAMDRHDGTSNGTARLPQLGTVGQSPYTSAPPLSHTPNADFQPPYFPPPYQPIY 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 PQSQDPYSHVNDPYSLNPLHAQPQPQHPGWPGQRQSQESGLLHTHRGLPHQLSGLDPRRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PQSQDPYSHVNDPYSLNPLHAQPQPQHPGWPGQRQSQESGLLHTHRGLPHQLSGLDPRRD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 YRRHEDLLHGPHALSSGLGDLSIHSLPHAIEEVPHVEDPGINIPDQTVIKKGPVSLSKSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YRRHEDLLHGPHALSSGLGDLSIHSLPHAIEEVPHVEDPGINIPDQTVIKKGPVSLSKSN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 SNAVSAIPINKDNLFGGVVNPNEVFCSVPGRLSLLSSTSKYKVTVAEVQRRLSPPECLNA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SNAVSAIPINKDNLFGGVVNPNEVFCSVPGRLSLLSSTSKYKVTVAEVQRRLSPPECLNA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 SLLGGVLRRAKSKNGGRSLREKLDKIGLNLPAGRRKAANVTLLTSLVEGEAVHLARDFGY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SLLGGVLRRAKSKNGGRSLREKLDKIGLNLPAGRRKAANVTLLTSLVEGEAVHLARDFGY 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB7 VCETEFPAKAVAEFLNRQHSDPNEQVTRKNMLLATKQICKEFTDLLAQDRSPLGNSRPNP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VCETEFPAKAVAEFLNRQHSDPNEQVTRKNMLLATKQICKEFTDLLAQDRSPLGNSRPNP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB7 ILEPGIQSCLTHFNLISHGFGSPAVCAAVTALQNYLTEALKAMDKMYLSNNPNSHTDNNA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ILEPGIQSCLTHFNLISHGFGSPAVCAAVTALQNYLTEALKAMDKMYLSNNPNSHTDNNA 370 380 390 400 410 420 430 pF1KB7 KSSDKEEKHRK ::::::::::: NP_001 KSSDKEEKHRK 430 >>NP_001035890 (OMIM: 107580,113620) transcription facto (433 aa) initn: 2872 init1: 2872 opt: 2872 Z-score: 1840.5 bits: 349.6 E(85289): 8.9e-96 Smith-Waterman score: 2872; 100.0% identity (100.0% similar) in 422 aa overlap (10-431:12-433) 10 20 30 40 50 pF1KB7 MLVHSFSAMDRHDGTSNGTARLPQLGTVGQSPYTSAPPLSHTPNADFQPPYFPPPYQP ::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSILAKMGDWQDRHDGTSNGTARLPQLGTVGQSPYTSAPPLSHTPNADFQPPYFPPPYQP 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB7 IYPQSQDPYSHVNDPYSLNPLHAQPQPQHPGWPGQRQSQESGLLHTHRGLPHQLSGLDPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IYPQSQDPYSHVNDPYSLNPLHAQPQPQHPGWPGQRQSQESGLLHTHRGLPHQLSGLDPR 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB7 RDYRRHEDLLHGPHALSSGLGDLSIHSLPHAIEEVPHVEDPGINIPDQTVIKKGPVSLSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RDYRRHEDLLHGPHALSSGLGDLSIHSLPHAIEEVPHVEDPGINIPDQTVIKKGPVSLSK 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB7 SNSNAVSAIPINKDNLFGGVVNPNEVFCSVPGRLSLLSSTSKYKVTVAEVQRRLSPPECL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SNSNAVSAIPINKDNLFGGVVNPNEVFCSVPGRLSLLSSTSKYKVTVAEVQRRLSPPECL 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB7 NASLLGGVLRRAKSKNGGRSLREKLDKIGLNLPAGRRKAANVTLLTSLVEGEAVHLARDF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NASLLGGVLRRAKSKNGGRSLREKLDKIGLNLPAGRRKAANVTLLTSLVEGEAVHLARDF 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB7 GYVCETEFPAKAVAEFLNRQHSDPNEQVTRKNMLLATKQICKEFTDLLAQDRSPLGNSRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GYVCETEFPAKAVAEFLNRQHSDPNEQVTRKNMLLATKQICKEFTDLLAQDRSPLGNSRP 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB7 NPILEPGIQSCLTHFNLISHGFGSPAVCAAVTALQNYLTEALKAMDKMYLSNNPNSHTDN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NPILEPGIQSCLTHFNLISHGFGSPAVCAAVTALQNYLTEALKAMDKMYLSNNPNSHTDN 370 380 390 400 410 420 420 430 pF1KB7 NAKSSDKEEKHRK ::::::::::::: NP_001 NAKSSDKEEKHRK 430 >>NP_003211 (OMIM: 107580,113620) transcription factor A (437 aa) initn: 2872 init1: 2872 opt: 2872 Z-score: 1840.4 bits: 349.6 E(85289): 9e-96 Smith-Waterman score: 2872; 100.0% identity (100.0% similar) in 422 aa overlap (10-431:16-437) 10 20 30 40 50 pF1KB7 MLVHSFSAMDRHDGTSNGTARLPQLGTVGQSPYTSAPPLSHTPNADFQPPYFPP ::::::::::::::::::::::::::::::::::::::::::::: NP_003 MLWKLTDNIKYEDCEDRHDGTSNGTARLPQLGTVGQSPYTSAPPLSHTPNADFQPPYFPP 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB7 PYQPIYPQSQDPYSHVNDPYSLNPLHAQPQPQHPGWPGQRQSQESGLLHTHRGLPHQLSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 PYQPIYPQSQDPYSHVNDPYSLNPLHAQPQPQHPGWPGQRQSQESGLLHTHRGLPHQLSG 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB7 LDPRRDYRRHEDLLHGPHALSSGLGDLSIHSLPHAIEEVPHVEDPGINIPDQTVIKKGPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 LDPRRDYRRHEDLLHGPHALSSGLGDLSIHSLPHAIEEVPHVEDPGINIPDQTVIKKGPV 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB7 SLSKSNSNAVSAIPINKDNLFGGVVNPNEVFCSVPGRLSLLSSTSKYKVTVAEVQRRLSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 SLSKSNSNAVSAIPINKDNLFGGVVNPNEVFCSVPGRLSLLSSTSKYKVTVAEVQRRLSP 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB7 PECLNASLLGGVLRRAKSKNGGRSLREKLDKIGLNLPAGRRKAANVTLLTSLVEGEAVHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 PECLNASLLGGVLRRAKSKNGGRSLREKLDKIGLNLPAGRRKAANVTLLTSLVEGEAVHL 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB7 ARDFGYVCETEFPAKAVAEFLNRQHSDPNEQVTRKNMLLATKQICKEFTDLLAQDRSPLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 ARDFGYVCETEFPAKAVAEFLNRQHSDPNEQVTRKNMLLATKQICKEFTDLLAQDRSPLG 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB7 NSRPNPILEPGIQSCLTHFNLISHGFGSPAVCAAVTALQNYLTEALKAMDKMYLSNNPNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 NSRPNPILEPGIQSCLTHFNLISHGFGSPAVCAAVTALQNYLTEALKAMDKMYLSNNPNS 370 380 390 400 410 420 420 430 pF1KB7 HTDNNAKSSDKEEKHRK ::::::::::::::::: NP_003 HTDNNAKSSDKEEKHRK 430 >>XP_006715238 (OMIM: 107580,113620) PREDICTED: transcri (482 aa) initn: 2872 init1: 2872 opt: 2872 Z-score: 1839.8 bits: 349.7 E(85289): 9.7e-96 Smith-Waterman score: 2872; 100.0% identity (100.0% similar) in 422 aa overlap (10-431:61-482) 10 20 30 pF1KB7 MLVHSFSAMDRHDGTSNGTARLPQLGTVGQSPYTSAPPL :::::::::::::::::::::::::::::: XP_006 SACRAESPTSARTRSQAAPTRYARPPLHPEDRHDGTSNGTARLPQLGTVGQSPYTSAPPL 40 50 60 70 80 90 40 50 60 70 80 90 pF1KB7 SHTPNADFQPPYFPPPYQPIYPQSQDPYSHVNDPYSLNPLHAQPQPQHPGWPGQRQSQES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SHTPNADFQPPYFPPPYQPIYPQSQDPYSHVNDPYSLNPLHAQPQPQHPGWPGQRQSQES 100 110 120 130 140 150 100 110 120 130 140 150 pF1KB7 GLLHTHRGLPHQLSGLDPRRDYRRHEDLLHGPHALSSGLGDLSIHSLPHAIEEVPHVEDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GLLHTHRGLPHQLSGLDPRRDYRRHEDLLHGPHALSSGLGDLSIHSLPHAIEEVPHVEDP 160 170 180 190 200 210 160 170 180 190 200 210 pF1KB7 GINIPDQTVIKKGPVSLSKSNSNAVSAIPINKDNLFGGVVNPNEVFCSVPGRLSLLSSTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GINIPDQTVIKKGPVSLSKSNSNAVSAIPINKDNLFGGVVNPNEVFCSVPGRLSLLSSTS 220 230 240 250 260 270 220 230 240 250 260 270 pF1KB7 KYKVTVAEVQRRLSPPECLNASLLGGVLRRAKSKNGGRSLREKLDKIGLNLPAGRRKAAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 KYKVTVAEVQRRLSPPECLNASLLGGVLRRAKSKNGGRSLREKLDKIGLNLPAGRRKAAN 280 290 300 310 320 330 280 290 300 310 320 330 pF1KB7 VTLLTSLVEGEAVHLARDFGYVCETEFPAKAVAEFLNRQHSDPNEQVTRKNMLLATKQIC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VTLLTSLVEGEAVHLARDFGYVCETEFPAKAVAEFLNRQHSDPNEQVTRKNMLLATKQIC 340 350 360 370 380 390 340 350 360 370 380 390 pF1KB7 KEFTDLLAQDRSPLGNSRPNPILEPGIQSCLTHFNLISHGFGSPAVCAAVTALQNYLTEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 KEFTDLLAQDRSPLGNSRPNPILEPGIQSCLTHFNLISHGFGSPAVCAAVTALQNYLTEA 400 410 420 430 440 450 400 410 420 430 pF1KB7 LKAMDKMYLSNNPNSHTDNNAKSSDKEEKHRK :::::::::::::::::::::::::::::::: XP_006 LKAMDKMYLSNNPNSHTDNNAKSSDKEEKHRK 460 470 480 >>XP_016866721 (OMIM: 107580,113620) PREDICTED: transcri (519 aa) initn: 2872 init1: 2872 opt: 2872 Z-score: 1839.3 bits: 349.7 E(85289): 1e-95 Smith-Waterman score: 2872; 100.0% identity (100.0% similar) in 422 aa overlap (10-431:98-519) 10 20 30 pF1KB7 MLVHSFSAMDRHDGTSNGTARLPQLGTVGQSPYTSAPPL :::::::::::::::::::::::::::::: XP_016 LCGAGTAAGGVNSWASAHASAGSNPALYDQDRHDGTSNGTARLPQLGTVGQSPYTSAPPL 70 80 90 100 110 120 40 50 60 70 80 90 pF1KB7 SHTPNADFQPPYFPPPYQPIYPQSQDPYSHVNDPYSLNPLHAQPQPQHPGWPGQRQSQES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SHTPNADFQPPYFPPPYQPIYPQSQDPYSHVNDPYSLNPLHAQPQPQHPGWPGQRQSQES 130 140 150 160 170 180 100 110 120 130 140 150 pF1KB7 GLLHTHRGLPHQLSGLDPRRDYRRHEDLLHGPHALSSGLGDLSIHSLPHAIEEVPHVEDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GLLHTHRGLPHQLSGLDPRRDYRRHEDLLHGPHALSSGLGDLSIHSLPHAIEEVPHVEDP 190 200 210 220 230 240 160 170 180 190 200 210 pF1KB7 GINIPDQTVIKKGPVSLSKSNSNAVSAIPINKDNLFGGVVNPNEVFCSVPGRLSLLSSTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GINIPDQTVIKKGPVSLSKSNSNAVSAIPINKDNLFGGVVNPNEVFCSVPGRLSLLSSTS 250 260 270 280 290 300 220 230 240 250 260 270 pF1KB7 KYKVTVAEVQRRLSPPECLNASLLGGVLRRAKSKNGGRSLREKLDKIGLNLPAGRRKAAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KYKVTVAEVQRRLSPPECLNASLLGGVLRRAKSKNGGRSLREKLDKIGLNLPAGRRKAAN 310 320 330 340 350 360 280 290 300 310 320 330 pF1KB7 VTLLTSLVEGEAVHLARDFGYVCETEFPAKAVAEFLNRQHSDPNEQVTRKNMLLATKQIC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VTLLTSLVEGEAVHLARDFGYVCETEFPAKAVAEFLNRQHSDPNEQVTRKNMLLATKQIC 370 380 390 400 410 420 340 350 360 370 380 390 pF1KB7 KEFTDLLAQDRSPLGNSRPNPILEPGIQSCLTHFNLISHGFGSPAVCAAVTALQNYLTEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KEFTDLLAQDRSPLGNSRPNPILEPGIQSCLTHFNLISHGFGSPAVCAAVTALQNYLTEA 430 440 450 460 470 480 400 410 420 430 pF1KB7 LKAMDKMYLSNNPNSHTDNNAKSSDKEEKHRK :::::::::::::::::::::::::::::::: XP_016 LKAMDKMYLSNNPNSHTDNNAKSSDKEEKHRK 490 500 510 >>XP_011513135 (OMIM: 107580,113620) PREDICTED: transcri (387 aa) initn: 2384 init1: 2384 opt: 2384 Z-score: 1532.1 bits: 292.4 E(85289): 1.3e-78 Smith-Waterman score: 2384; 100.0% identity (100.0% similar) in 356 aa overlap (76-431:32-387) 50 60 70 80 90 100 pF1KB7 DFQPPYFPPPYQPIYPQSQDPYSHVNDPYSLNPLHAQPQPQHPGWPGQRQSQESGLLHTH :::::::::::::::::::::::::::::: XP_011 RRQVATQLFMTRTVTTAPATGRHGCPSWALLNPLHAQPQPQHPGWPGQRQSQESGLLHTH 10 20 30 40 50 60 110 120 130 140 150 160 pF1KB7 RGLPHQLSGLDPRRDYRRHEDLLHGPHALSSGLGDLSIHSLPHAIEEVPHVEDPGINIPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RGLPHQLSGLDPRRDYRRHEDLLHGPHALSSGLGDLSIHSLPHAIEEVPHVEDPGINIPD 70 80 90 100 110 120 170 180 190 200 210 220 pF1KB7 QTVIKKGPVSLSKSNSNAVSAIPINKDNLFGGVVNPNEVFCSVPGRLSLLSSTSKYKVTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QTVIKKGPVSLSKSNSNAVSAIPINKDNLFGGVVNPNEVFCSVPGRLSLLSSTSKYKVTV 130 140 150 160 170 180 230 240 250 260 270 280 pF1KB7 AEVQRRLSPPECLNASLLGGVLRRAKSKNGGRSLREKLDKIGLNLPAGRRKAANVTLLTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AEVQRRLSPPECLNASLLGGVLRRAKSKNGGRSLREKLDKIGLNLPAGRRKAANVTLLTS 190 200 210 220 230 240 290 300 310 320 330 340 pF1KB7 LVEGEAVHLARDFGYVCETEFPAKAVAEFLNRQHSDPNEQVTRKNMLLATKQICKEFTDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LVEGEAVHLARDFGYVCETEFPAKAVAEFLNRQHSDPNEQVTRKNMLLATKQICKEFTDL 250 260 270 280 290 300 350 360 370 380 390 400 pF1KB7 LAQDRSPLGNSRPNPILEPGIQSCLTHFNLISHGFGSPAVCAAVTALQNYLTEALKAMDK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LAQDRSPLGNSRPNPILEPGIQSCLTHFNLISHGFGSPAVCAAVTALQNYLTEALKAMDK 310 320 330 340 350 360 410 420 430 pF1KB7 MYLSNNPNSHTDNNAKSSDKEEKHRK :::::::::::::::::::::::::: XP_011 MYLSNNPNSHTDNNAKSSDKEEKHRK 370 380 >>XP_011513139 (OMIM: 169100,601601,617035) PREDICTED: t (469 aa) initn: 1966 init1: 1259 opt: 2046 Z-score: 1316.7 bits: 252.8 E(85289): 1.3e-66 Smith-Waterman score: 2063; 71.8% identity (87.1% similar) in 451 aa overlap (1-431:28-469) 10 20 30 pF1KB7 MLVHSFSAMDRHDGTSNGTARLPQLGTVGQSPY ::::..:.::::::. . ..:: :::.:.:.:: XP_011 MHSPPRDQAAIMLWKLVENVKYEDIYEMLVHTYSSMDRHDGVPSHSSRLSQLGSVSQGPY 10 20 30 40 50 60 40 50 60 70 80 90 pF1KB7 TSAPPLSHTPNADFQPPYFPPPYQPI-YPQSQDPYSHVNDPYSLNPLHAQPQPQHPGWPG .:::::::::..:::::::::::::. : ::::::::::::::::::: ::: ::: : : XP_011 SSAPPLSHTPSSDFQPPYFPPPYQPLPYHQSQDPYSHVNDPYSLNPLH-QPQ-QHP-W-G 70 80 90 100 110 100 110 120 130 140 pF1KB7 QRQSQESG-----LLHTHRGLPHQLSGLDPRRDY---RRHEDLLHGPH-ALSSGLGD-LS ::: :: : :: :. ::::::::::: :: . :::. : .:..:.:: :: XP_011 QRQRQEVGSEAGSLLPQPRAALPQLSGLDPRRDYHSVRRPDVLLHSAHHGLDAGMGDSLS 120 130 140 150 160 170 150 160 170 180 190 pF1KB7 IHSLPH-AIEEVPHVEDP---GINIPDQTVIKKGPVSLSKSNSNAVSAIPINKDNLFGGV .:.: : ..:.: ::: :.:. ::.:::: :: ..:... .:::...::. XP_011 LHGLGHPGMEDVQSVEDANNSGMNLLDQSVIKKVPVP-----PKSVTSLMMNKDGFLGGM 180 190 200 210 220 230 200 210 220 230 240 250 pF1KB7 -VNPNEVFCSVPGRLSLLSSTSKYKVTVAEVQRRLSPPECLNASLLGGVLRRAKSKNGGR :: .:::::::::::::::::::::::.::::::::::::::::::::::::::::::: XP_011 SVNTGEVFCSVPGRLSLLSSTSKYKVTVGEVQRRLSPPECLNASLLGGVLRRAKSKNGGR 240 250 260 270 280 290 260 270 280 290 300 310 pF1KB7 SLREKLDKIGLNLPAGRRKAANVTLLTSLVEGEAVHLARDFGYVCETEFPAKAVAEFLNR ::::.:.::::::::::::::::::::::::::::::::::::.::::::::::.:.::: XP_011 SLRERLEKIGLNLPAGRRKAANVTLLTSLVEGEAVHLARDFGYICETEFPAKAVSEYLNR 300 310 320 330 340 350 320 330 340 350 360 370 pF1KB7 QHSDPNEQVTRKNMLLATKQICKEFTDLLAQDRSPLGNSRPNPILEPGIQSCLTHFNLIS ::.::.. .::::::::::.::::::::::::.:.:::::.::::::::::::::.::. XP_011 QHTDPSDLHSRKNMLLATKQLCKEFTDLLAQDRTPIGNSRPSPILEPGIQSCLTHFSLIT 360 370 380 390 400 410 380 390 400 410 420 430 pF1KB7 HGFGSPAVCAAVTALQNYLTEALKAMDKMYLSNNP-NSHTDNN---AKSSDKEEKHRK ::::.::.:::.::::::::::::.::::.:.:. : ::... .:..:::::::: XP_011 HGFGAPAICAALTALQNYLTEALKGMDKMFLNNTTTNRHTSGEGPGSKTGDKEEKHRK 420 430 440 450 460 >>XP_016866723 (OMIM: 169100,601601,617035) PREDICTED: t (503 aa) initn: 1942 init1: 1259 opt: 2046 Z-score: 1316.3 bits: 252.9 E(85289): 1.4e-66 Smith-Waterman score: 2063; 71.8% identity (87.1% similar) in 451 aa overlap (1-431:62-503) 10 20 30 pF1KB7 MLVHSFSAMDRHDGTSNGTARLPQLGTVGQ ::::..:.::::::. . ..:: :::.:.: XP_016 SGSLWRMSSTKISMSTQGDQVLRIREVSLQMLVHTYSSMDRHDGVPSHSSRLSQLGSVSQ 40 50 60 70 80 90 40 50 60 70 80 pF1KB7 SPYTSAPPLSHTPNADFQPPYFPPPYQPI-YPQSQDPYSHVNDPYSLNPLHAQPQPQHPG .::.:::::::::..:::::::::::::. : ::::::::::::::::::: ::: ::: XP_016 GPYSSAPPLSHTPSSDFQPPYFPPPYQPLPYHQSQDPYSHVNDPYSLNPLH-QPQ-QHP- 100 110 120 130 140 90 100 110 120 130 140 pF1KB7 WPGQRQSQESG-----LLHTHRGLPHQLSGLDPRRDY---RRHEDLLHGPH-ALSSGLGD : :::: :: : :: :. ::::::::::: :: . :::. : .:..:.:: XP_016 W-GQRQRQEVGSEAGSLLPQPRAALPQLSGLDPRRDYHSVRRPDVLLHSAHHGLDAGMGD 150 160 170 180 190 200 150 160 170 180 190 pF1KB7 -LSIHSLPH-AIEEVPHVEDP---GINIPDQTVIKKGPVSLSKSNSNAVSAIPINKDNLF ::.:.: : ..:.: ::: :.:. ::.:::: :: ..:... .:::... XP_016 SLSLHGLGHPGMEDVQSVEDANNSGMNLLDQSVIKKVPVP-----PKSVTSLMMNKDGFL 210 220 230 240 250 260 200 210 220 230 240 250 pF1KB7 GGV-VNPNEVFCSVPGRLSLLSSTSKYKVTVAEVQRRLSPPECLNASLLGGVLRRAKSKN ::. :: .:::::::::::::::::::::::.:::::::::::::::::::::::::::: XP_016 GGMSVNTGEVFCSVPGRLSLLSSTSKYKVTVGEVQRRLSPPECLNASLLGGVLRRAKSKN 270 280 290 300 310 320 260 270 280 290 300 310 pF1KB7 GGRSLREKLDKIGLNLPAGRRKAANVTLLTSLVEGEAVHLARDFGYVCETEFPAKAVAEF :::::::.:.::::::::::::::::::::::::::::::::::::.::::::::::.:. XP_016 GGRSLRERLEKIGLNLPAGRRKAANVTLLTSLVEGEAVHLARDFGYICETEFPAKAVSEY 330 340 350 360 370 380 320 330 340 350 360 370 pF1KB7 LNRQHSDPNEQVTRKNMLLATKQICKEFTDLLAQDRSPLGNSRPNPILEPGIQSCLTHFN :::::.::.. .::::::::::.::::::::::::.:.:::::.::::::::::::::. XP_016 LNRQHTDPSDLHSRKNMLLATKQLCKEFTDLLAQDRTPIGNSRPSPILEPGIQSCLTHFS 390 400 410 420 430 440 380 390 400 410 420 430 pF1KB7 LISHGFGSPAVCAAVTALQNYLTEALKAMDKMYLSNNP-NSHTDNN---AKSSDKEEKHR ::.::::.::.:::.::::::::::::.::::.:.:. : ::... .:..::::::: XP_016 LITHGFGAPAICAALTALQNYLTEALKGMDKMFLNNTTTNRHTSGEGPGSKTGDKEEKHR 450 460 470 480 490 500 pF1KB7 K : XP_016 K >>XP_016866722 (OMIM: 169100,601601,617035) PREDICTED: t (515 aa) initn: 1942 init1: 1259 opt: 2046 Z-score: 1316.1 bits: 252.9 E(85289): 1.4e-66 Smith-Waterman score: 2063; 71.8% identity (87.1% similar) in 451 aa overlap (1-431:74-515) 10 20 30 pF1KB7 MLVHSFSAMDRHDGTSNGTARLPQLGTVGQ ::::..:.::::::. . ..:: :::.:.: XP_016 SGSLWRMSSTKISMSTQGDQVLRIREVSLQMLVHTYSSMDRHDGVPSHSSRLSQLGSVSQ 50 60 70 80 90 100 40 50 60 70 80 pF1KB7 SPYTSAPPLSHTPNADFQPPYFPPPYQPI-YPQSQDPYSHVNDPYSLNPLHAQPQPQHPG .::.:::::::::..:::::::::::::. : ::::::::::::::::::: ::: ::: XP_016 GPYSSAPPLSHTPSSDFQPPYFPPPYQPLPYHQSQDPYSHVNDPYSLNPLH-QPQ-QHP- 110 120 130 140 150 160 90 100 110 120 130 140 pF1KB7 WPGQRQSQESG-----LLHTHRGLPHQLSGLDPRRDY---RRHEDLLHGPH-ALSSGLGD : :::: :: : :: :. ::::::::::: :: . :::. : .:..:.:: XP_016 W-GQRQRQEVGSEAGSLLPQPRAALPQLSGLDPRRDYHSVRRPDVLLHSAHHGLDAGMGD 170 180 190 200 210 150 160 170 180 190 pF1KB7 -LSIHSLPH-AIEEVPHVEDP---GINIPDQTVIKKGPVSLSKSNSNAVSAIPINKDNLF ::.:.: : ..:.: ::: :.:. ::.:::: :: ..:... .:::... XP_016 SLSLHGLGHPGMEDVQSVEDANNSGMNLLDQSVIKKVPVP-----PKSVTSLMMNKDGFL 220 230 240 250 260 270 200 210 220 230 240 250 pF1KB7 GGV-VNPNEVFCSVPGRLSLLSSTSKYKVTVAEVQRRLSPPECLNASLLGGVLRRAKSKN ::. :: .:::::::::::::::::::::::.:::::::::::::::::::::::::::: XP_016 GGMSVNTGEVFCSVPGRLSLLSSTSKYKVTVGEVQRRLSPPECLNASLLGGVLRRAKSKN 280 290 300 310 320 330 260 270 280 290 300 310 pF1KB7 GGRSLREKLDKIGLNLPAGRRKAANVTLLTSLVEGEAVHLARDFGYVCETEFPAKAVAEF :::::::.:.::::::::::::::::::::::::::::::::::::.::::::::::.:. XP_016 GGRSLRERLEKIGLNLPAGRRKAANVTLLTSLVEGEAVHLARDFGYICETEFPAKAVSEY 340 350 360 370 380 390 320 330 340 350 360 370 pF1KB7 LNRQHSDPNEQVTRKNMLLATKQICKEFTDLLAQDRSPLGNSRPNPILEPGIQSCLTHFN :::::.::.. .::::::::::.::::::::::::.:.:::::.::::::::::::::. XP_016 LNRQHTDPSDLHSRKNMLLATKQLCKEFTDLLAQDRTPIGNSRPSPILEPGIQSCLTHFS 400 410 420 430 440 450 380 390 400 410 420 430 pF1KB7 LISHGFGSPAVCAAVTALQNYLTEALKAMDKMYLSNNP-NSHTDNN---AKSSDKEEKHR ::.::::.::.:::.::::::::::::.::::.:.:. : ::... .:..::::::: XP_016 LITHGFGAPAICAALTALQNYLTEALKGMDKMFLNNTTTNRHTSGEGPGSKTGDKEEKHR 460 470 480 490 500 510 pF1KB7 K : XP_016 K >>NP_003212 (OMIM: 169100,601601,617035) transcription f (460 aa) initn: 1920 init1: 1259 opt: 2000 Z-score: 1287.7 bits: 247.4 E(85289): 5.5e-65 Smith-Waterman score: 2017; 71.9% identity (86.9% similar) in 442 aa overlap (10-431:28-460) 10 20 30 40 pF1KB7 MLVHSFSAMDRHDGTSNGTARLPQLGTVGQSPYTSAPPLSHT :::::. . ..:: :::.:.:.::.:::::::: NP_003 MHSPPRDQAAIMLWKLVENVKYEDIYEDRHDGVPSHSSRLSQLGSVSQGPYSSAPPLSHT 10 20 30 40 50 60 50 60 70 80 90 100 pF1KB7 PNADFQPPYFPPPYQPI-YPQSQDPYSHVNDPYSLNPLHAQPQPQHPGWPGQRQSQESG- :..:::::::::::::. : ::::::::::::::::::: ::: ::: : :::: :: : NP_003 PSSDFQPPYFPPPYQPLPYHQSQDPYSHVNDPYSLNPLH-QPQ-QHP-W-GQRQRQEVGS 70 80 90 100 110 110 120 130 140 150 pF1KB7 ----LLHTHRGLPHQLSGLDPRRDY---RRHEDLLHGPH-ALSSGLGD-LSIHSLPH-AI :: :. ::::::::::: :: . :::. : .:..:.:: ::.:.: : .. NP_003 EAGSLLPQPRAALPQLSGLDPRRDYHSVRRPDVLLHSAHHGLDAGMGDSLSLHGLGHPGM 120 130 140 150 160 170 160 170 180 190 200 pF1KB7 EEVPHVEDP---GINIPDQTVIKKGPVSLSKSNSNAVSAIPINKDNLFGGV-VNPNEVFC :.: ::: :.:. ::.:::: :: ..:... .:::...::. :: .:::: NP_003 EDVQSVEDANNSGMNLLDQSVIKKVPVP-----PKSVTSLMMNKDGFLGGMSVNTGEVFC 180 190 200 210 220 230 210 220 230 240 250 260 pF1KB7 SVPGRLSLLSSTSKYKVTVAEVQRRLSPPECLNASLLGGVLRRAKSKNGGRSLREKLDKI :::::::::::::::::::.:::::::::::::::::::::::::::::::::::.:.:: NP_003 SVPGRLSLLSSTSKYKVTVGEVQRRLSPPECLNASLLGGVLRRAKSKNGGRSLRERLEKI 240 250 260 270 280 290 270 280 290 300 310 320 pF1KB7 GLNLPAGRRKAANVTLLTSLVEGEAVHLARDFGYVCETEFPAKAVAEFLNRQHSDPNEQV ::::::::::::::::::::::::::::::::::.::::::::::.:.:::::.::.. NP_003 GLNLPAGRRKAANVTLLTSLVEGEAVHLARDFGYICETEFPAKAVSEYLNRQHTDPSDLH 300 310 320 330 340 350 330 340 350 360 370 380 pF1KB7 TRKNMLLATKQICKEFTDLLAQDRSPLGNSRPNPILEPGIQSCLTHFNLISHGFGSPAVC .::::::::::.::::::::::::.:.:::::.::::::::::::::.::.::::.::.: NP_003 SRKNMLLATKQLCKEFTDLLAQDRTPIGNSRPSPILEPGIQSCLTHFSLITHGFGAPAIC 360 370 380 390 400 410 390 400 410 420 430 pF1KB7 AAVTALQNYLTEALKAMDKMYLSNNP-NSHTDNN---AKSSDKEEKHRK ::.::::::::::::.::::.:.:. : ::... .:..:::::::: NP_003 AALTALQNYLTEALKGMDKMFLNNTTTNRHTSGEGPGSKTGDKEEKHRK 420 430 440 450 460 431 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 21:28:16 2016 done: Sat Nov 5 21:28:17 2016 Total Scan time: 9.550 Total Display time: 0.060 Function used was FASTA [36.3.4 Apr, 2011]