FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8003, 163 aa 1>>>pF1KB8003 163 - 163 aa - 163 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.6336+/-0.000294; mu= 11.3737+/- 0.018 mean_var=88.0988+/-17.722, 0's: 0 Z-trim(119.7): 116 B-trim: 1599 in 1/54 Lambda= 0.136644 statistics sampled from 33870 (34043) to 33870 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.769), E-opt: 0.2 (0.399), width: 16 Scan time: 4.640 The best scores are: opt bits E(85289) NP_006212 (OMIM: 601052) peptidyl-prolyl cis-trans ( 163) 1096 225.0 4.2e-59 XP_011526370 (OMIM: 601052) PREDICTED: peptidyl-pr ( 168) 962 198.6 3.8e-51 NP_006214 (OMIM: 300252) peptidyl-prolyl cis-trans ( 156) 190 46.4 2.3e-05 XP_011527381 (OMIM: 606409,613385) PREDICTED: E3 u ( 692) 155 40.0 0.0088 XP_005260627 (OMIM: 606409,613385) PREDICTED: E3 u ( 692) 155 40.0 0.0088 XP_016883580 (OMIM: 606409,613385) PREDICTED: E3 u ( 752) 155 40.0 0.0094 NP_001244067 (OMIM: 606409,613385) E3 ubiquitin-pr ( 752) 155 40.0 0.0094 >>NP_006212 (OMIM: 601052) peptidyl-prolyl cis-trans iso (163 aa) initn: 1096 init1: 1096 opt: 1096 Z-score: 1182.2 bits: 225.0 E(85289): 4.2e-59 Smith-Waterman score: 1096; 100.0% identity (100.0% similar) in 163 aa overlap (1-163:1-163) 10 20 30 40 50 60 pF1KB8 MADEEKLPPGWEKRMSRSSGRVYYFNHITNASQWERPSGNSSSGGKNGQGEPARVRCSHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 MADEEKLPPGWEKRMSRSSGRVYYFNHITNASQWERPSGNSSSGGKNGQGEPARVRCSHL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 LVKHSQSRRPSSWRQEKITRTKEEALELINGYIQKIKSGEEDFESLASQFSDCSSAKARG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 LVKHSQSRRPSSWRQEKITRTKEEALELINGYIQKIKSGEEDFESLASQFSDCSSAKARG 70 80 90 100 110 120 130 140 150 160 pF1KB8 DLGAFSRGQMQKPFEDASFALRTGEMSGPVFTDSGIHIILRTE ::::::::::::::::::::::::::::::::::::::::::: NP_006 DLGAFSRGQMQKPFEDASFALRTGEMSGPVFTDSGIHIILRTE 130 140 150 160 >>XP_011526370 (OMIM: 601052) PREDICTED: peptidyl-prolyl (168 aa) initn: 962 init1: 962 opt: 962 Z-score: 1039.2 bits: 198.6 E(85289): 3.8e-51 Smith-Waterman score: 962; 100.0% identity (100.0% similar) in 144 aa overlap (20-163:25-168) 10 20 30 40 50 pF1KB8 MADEEKLPPGWEKRMSRSSGRVYYFNHITNASQWERPSGNSSSGGKNGQGEPARV :::::::::::::::::::::::::::::::::::: XP_011 MQKVRTPRPREDISHLNPDSDLNPGRVYYFNHITNASQWERPSGNSSSGGKNGQGEPARV 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB8 RCSHLLVKHSQSRRPSSWRQEKITRTKEEALELINGYIQKIKSGEEDFESLASQFSDCSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RCSHLLVKHSQSRRPSSWRQEKITRTKEEALELINGYIQKIKSGEEDFESLASQFSDCSS 70 80 90 100 110 120 120 130 140 150 160 pF1KB8 AKARGDLGAFSRGQMQKPFEDASFALRTGEMSGPVFTDSGIHIILRTE :::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AKARGDLGAFSRGQMQKPFEDASFALRTGEMSGPVFTDSGIHIILRTE 130 140 150 160 >>NP_006214 (OMIM: 300252) peptidyl-prolyl cis-trans iso (156 aa) initn: 210 init1: 127 opt: 190 Z-score: 217.2 bits: 46.4 E(85289): 2.3e-05 Smith-Waterman score: 190; 36.2% identity (62.3% similar) in 130 aa overlap (37-160:28-151) 10 20 30 40 50 60 pF1KB8 LPPGWEKRMSRSSGRVYYFNHITNASQWERPSGNSSSGGKNGQGEPARVRCSHLLVKHSQ :.:.:.:: : :.: : : :..: NP_006 MPMAGLLKGLVRQLERFSVQQQASKMPPKGKSGSG-KAGKGGAA--SGSDSADKKAQ 10 20 30 40 50 70 80 90 100 110 120 pF1KB8 SRRPSSWRQEKITRTKEEALELINGYIQKIKSGEEDFESLASQFSDCSSAKARGDLGAFS . . .. :. . : : ..:.::: . :. .:.:.:. ..:. :::: .. NP_006 GPKGGG-NAVKVRHILCEKHGKIMEAMEKLKSGMR-FNEVAAQYSE-DKARQGGDLGWMT 60 70 80 90 100 110 130 140 150 160 pF1KB8 RGQMQKPFEDASFALRTGEMSGPVFTDS------GIHIILRTE ::.: ::..:.::: .. :. ::::: : :::. NP_006 RGSMVGPFQEAAFALPVSGMDKPVFTDPPVKTKFGYHIIMVEGRK 120 130 140 150 >>XP_011527381 (OMIM: 606409,613385) PREDICTED: E3 ubiqu (692 aa) initn: 208 init1: 94 opt: 155 Z-score: 170.9 bits: 40.0 E(85289): 0.0088 Smith-Waterman score: 155; 31.8% identity (59.1% similar) in 110 aa overlap (7-111:229-332) 10 20 30 pF1KB8 MADEEKLPPGWEKRMSRSSGRVYYFNHITNASQWER :::::::: . :.::::. :: : .::: XP_011 AMQQFNQRFIYGNQDLFATSQSKEFDPLGPLPPGWEKR-TDSNGRVYFVNHNTRITQWED 200 210 220 230 240 250 40 50 60 70 80 90 pF1KB8 PSGNSSSGGKN-GQGEPARVRCSHLLVKHSQSRRPSSWRQEKITRTKEEALELING---- : .... . : .: : . . ...:: ... . :: . ::. :: XP_011 PRSQGQLNEKPLPEGWEMRFTVDGIPYFVDHNRRTTTYIDP---RTGKSALD--NGPQIA 260 270 280 290 300 310 100 110 120 130 140 150 pF1KB8 YIQKIKSGEEDFESLASQFSDCSSAKARGDLGAFSRGQMQKPFEDASFALRTGEMSGPVF :.. .:. . :. .:.. XP_011 YVRDFKAKVQYFRFWCQQLAMPQHIKITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIFPG 320 330 340 350 360 370 >>XP_005260627 (OMIM: 606409,613385) PREDICTED: E3 ubiqu (692 aa) initn: 208 init1: 94 opt: 155 Z-score: 170.9 bits: 40.0 E(85289): 0.0088 Smith-Waterman score: 155; 31.8% identity (59.1% similar) in 110 aa overlap (7-111:229-332) 10 20 30 pF1KB8 MADEEKLPPGWEKRMSRSSGRVYYFNHITNASQWER :::::::: . :.::::. :: : .::: XP_005 AMQQFNQRFIYGNQDLFATSQSKEFDPLGPLPPGWEKR-TDSNGRVYFVNHNTRITQWED 200 210 220 230 240 250 40 50 60 70 80 90 pF1KB8 PSGNSSSGGKN-GQGEPARVRCSHLLVKHSQSRRPSSWRQEKITRTKEEALELING---- : .... . : .: : . . ...:: ... . :: . ::. :: XP_005 PRSQGQLNEKPLPEGWEMRFTVDGIPYFVDHNRRTTTYIDP---RTGKSALD--NGPQIA 260 270 280 290 300 310 100 110 120 130 140 150 pF1KB8 YIQKIKSGEEDFESLASQFSDCSSAKARGDLGAFSRGQMQKPFEDASFALRTGEMSGPVF :.. .:. . :. .:.. XP_005 YVRDFKAKVQYFRFWCQQLAMPQHIKITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIFPG 320 330 340 350 360 370 >>XP_016883580 (OMIM: 606409,613385) PREDICTED: E3 ubiqu (752 aa) initn: 208 init1: 94 opt: 155 Z-score: 170.4 bits: 40.0 E(85289): 0.0094 Smith-Waterman score: 155; 31.8% identity (59.1% similar) in 110 aa overlap (7-111:289-392) 10 20 30 pF1KB8 MADEEKLPPGWEKRMSRSSGRVYYFNHITNASQWER :::::::: . :.::::. :: : .::: XP_016 AMQQFNQRFIYGNQDLFATSQSKEFDPLGPLPPGWEKR-TDSNGRVYFVNHNTRITQWED 260 270 280 290 300 310 40 50 60 70 80 90 pF1KB8 PSGNSSSGGKN-GQGEPARVRCSHLLVKHSQSRRPSSWRQEKITRTKEEALELING---- : .... . : .: : . . ...:: ... . :: . ::. :: XP_016 PRSQGQLNEKPLPEGWEMRFTVDGIPYFVDHNRRTTTYIDP---RTGKSALD--NGPQIA 320 330 340 350 360 370 100 110 120 130 140 150 pF1KB8 YIQKIKSGEEDFESLASQFSDCSSAKARGDLGAFSRGQMQKPFEDASFALRTGEMSGPVF :.. .:. . :. .:.. XP_016 YVRDFKAKVQYFRFWCQQLAMPQHIKITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIFPG 380 390 400 410 420 430 >>NP_001244067 (OMIM: 606409,613385) E3 ubiquitin-protei (752 aa) initn: 208 init1: 94 opt: 155 Z-score: 170.4 bits: 40.0 E(85289): 0.0094 Smith-Waterman score: 155; 31.8% identity (59.1% similar) in 110 aa overlap (7-111:289-392) 10 20 30 pF1KB8 MADEEKLPPGWEKRMSRSSGRVYYFNHITNASQWER :::::::: . :.::::. :: : .::: NP_001 AMQQFNQRFIYGNQDLFATSQSKEFDPLGPLPPGWEKR-TDSNGRVYFVNHNTRITQWED 260 270 280 290 300 310 40 50 60 70 80 90 pF1KB8 PSGNSSSGGKN-GQGEPARVRCSHLLVKHSQSRRPSSWRQEKITRTKEEALELING---- : .... . : .: : . . ...:: ... . :: . ::. :: NP_001 PRSQGQLNEKPLPEGWEMRFTVDGIPYFVDHNRRTTTYIDP---RTGKSALD--NGPQIA 320 330 340 350 360 370 100 110 120 130 140 150 pF1KB8 YIQKIKSGEEDFESLASQFSDCSSAKARGDLGAFSRGQMQKPFEDASFALRTGEMSGPVF :.. .:. . :. .:.. NP_001 YVRDFKAKVQYFRFWCQQLAMPQHIKITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIFPG 380 390 400 410 420 430 163 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Wed Nov 2 23:12:25 2016 done: Wed Nov 2 23:12:26 2016 Total Scan time: 4.640 Total Display time: -0.020 Function used was FASTA [36.3.4 Apr, 2011]