FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8101, 447 aa 1>>>pF1KB8101 447 - 447 aa - 447 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.4771+/-0.00103; mu= 16.4588+/- 0.062 mean_var=62.8857+/-12.529, 0's: 0 Z-trim(102.6): 23 B-trim: 50 in 2/47 Lambda= 0.161733 statistics sampled from 7000 (7012) to 7000 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.58), E-opt: 0.2 (0.215), width: 16 Scan time: 2.750 The best scores are: opt bits E(32554) CCDS35452.1 GDI1 gene_id:2664|Hs108|chrX ( 447) 2986 705.7 2.3e-203 CCDS7071.1 GDI2 gene_id:2665|Hs108|chr10 ( 445) 2642 625.5 3.3e-179 CCDS44352.1 GDI2 gene_id:2665|Hs108|chr10 ( 400) 1864 443.9 1.3e-124 CCDS31073.1 CHML gene_id:1122|Hs108|chr1 ( 656) 435 110.6 4.9e-24 CCDS14454.1 CHM gene_id:1121|Hs108|chrX ( 653) 399 102.2 1.7e-21 >>CCDS35452.1 GDI1 gene_id:2664|Hs108|chrX (447 aa) initn: 2986 init1: 2986 opt: 2986 Z-score: 3764.5 bits: 705.7 E(32554): 2.3e-203 Smith-Waterman score: 2986; 100.0% identity (100.0% similar) in 447 aa overlap (1-447:1-447) 10 20 30 40 50 60 pF1KB8 MDEEYDVIVLGTGLTECILSGIMSVNGKKVLHMDRNPYYGGESSSITPLEELYKRFQLLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS35 MDEEYDVIVLGTGLTECILSGIMSVNGKKVLHMDRNPYYGGESSSITPLEELYKRFQLLE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 GPPESMGRGRDWNVDLIPKFLMANGQLVKMLLYTEVTRYLDFKVVEGSFVYKGGKIYKVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS35 GPPESMGRGRDWNVDLIPKFLMANGQLVKMLLYTEVTRYLDFKVVEGSFVYKGGKIYKVP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 STETEALASNLMGMFEKRRFRKFLVFVANFDENDPKTFEGVDPQTTSMRDVYRKFDLGQD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS35 STETEALASNLMGMFEKRRFRKFLVFVANFDENDPKTFEGVDPQTTSMRDVYRKFDLGQD 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 VIDFTGHALALYRTDDYLDQPCLETVNRIKLYSESLARYGKSPYLYPLYGLGELPQGFAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS35 VIDFTGHALALYRTDDYLDQPCLETVNRIKLYSESLARYGKSPYLYPLYGLGELPQGFAR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 LSAIYGGTYMLNKPVDDIIMENGKVVGVKSEGEVARCKQLICDPSYIPDRVRKAGQVIRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS35 LSAIYGGTYMLNKPVDDIIMENGKVVGVKSEGEVARCKQLICDPSYIPDRVRKAGQVIRI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 ICILSHPIKNTNDANSCQIIIPQNQVNRKSDIYVCMISYAHNVAAQGKYIAIASTTVETT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS35 ICILSHPIKNTNDANSCQIIIPQNQVNRKSDIYVCMISYAHNVAAQGKYIAIASTTVETT 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 DPEKEVEPALELLEPIDQKFVAISDLYEPIDDGCESQVFCSCSYDATTHFETTCNDIKDI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS35 DPEKEVEPALELLEPIDQKFVAISDLYEPIDDGCESQVFCSCSYDATTHFETTCNDIKDI 370 380 390 400 410 420 430 440 pF1KB8 YKRMAGTAFDFENMKRKQNDVFGEAEQ ::::::::::::::::::::::::::: CCDS35 YKRMAGTAFDFENMKRKQNDVFGEAEQ 430 440 >>CCDS7071.1 GDI2 gene_id:2665|Hs108|chr10 (445 aa) initn: 2642 init1: 2642 opt: 2642 Z-score: 3330.7 bits: 625.5 E(32554): 3.3e-179 Smith-Waterman score: 2642; 86.5% identity (96.8% similar) in 444 aa overlap (1-444:1-444) 10 20 30 40 50 60 pF1KB8 MDEEYDVIVLGTGLTECILSGIMSVNGKKVLHMDRNPYYGGESSSITPLEELYKRFQLLE :.:::::::::::::::::::::::::::::::::::::::::.::::::.:::::.. CCDS70 MNEEYDVIVLGTGLTECILSGIMSVNGKKVLHMDRNPYYGGESASITPLEDLYKRFKIPG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 GPPESMGRGRDWNVDLIPKFLMANGQLVKMLLYTEVTRYLDFKVVEGSFVYKGGKIYKVP .:::::::::::::::::::::::::::::::::::::::::::.::::::::::::::: CCDS70 SPPESMGRGRDWNVDLIPKFLMANGQLVKMLLYTEVTRYLDFKVTEGSFVYKGGKIYKVP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 STETEALASNLMGMFEKRRFRKFLVFVANFDENDPKTFEGVDPQTTSMRDVYRKFDLGQD :::.:::::.:::.:::::::::::.::::::.::.::::.::. :.:::::.::::::: CCDS70 STEAEALASSLMGLFEKRRFRKFLVYVANFDEKDPRTFEGIDPKKTTMRDVYKKFDLGQD 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 VIDFTGHALALYRTDDYLDQPCLETVNRIKLYSESLARYGKSPYLYPLYGLGELPQGFAR :::::::::::::::::::::: ::.:::::::::::::::::::::::::::::::::: CCDS70 VIDFTGHALALYRTDDYLDQPCYETINRIKLYSESLARYGKSPYLYPLYGLGELPQGFAR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 LSAIYGGTYMLNKPVDDIIMENGKVVGVKSEGEVARCKQLICDPSYIPDRVRKAGQVIRI ::::::::::::::...::..::::.:::::::.::::::::::::. :::.:.:::::. CCDS70 LSAIYGGTYMLNKPIEEIIVQNGKVIGVKSEGEIARCKQLICDPSYVKDRVEKVGQVIRV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 ICILSHPIKNTNDANSCQIIIPQNQVNRKSDIYVCMISYAHNVAAQGKYIAIASTTVETT ::::::::::::::::::::::::::::::::::::::.:::::::::::::.:::::: CCDS70 ICILSHPIKNTNDANSCQIIIPQNQVNRKSDIYVCMISFAHNVAAQGKYIAIVSTTVETK 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 DPEKEVEPALELLEPIDQKFVAISDLYEPIDDGCESQVFCSCSYDATTHFETTCNDIKDI .::::..:::::::::.::::.:::: : : : :::.: : .:::::::::::.:::.: CCDS70 EPEKEIRPALELLEPIEQKFVSISDLLVPKDLGTESQIFISRTYDATTHFETTCDDIKNI 370 380 390 400 410 420 430 440 pF1KB8 YKRMAGTAFDFENMKRKQNDVFGEAEQ ::::.:. ::::.::::.::..:: CCDS70 YKRMTGSEFDFEEMKRKKNDIYGED 430 440 >>CCDS44352.1 GDI2 gene_id:2665|Hs108|chr10 (400 aa) initn: 1862 init1: 1862 opt: 1864 Z-score: 2350.4 bits: 443.9 E(32554): 1.3e-124 Smith-Waterman score: 2281; 77.0% identity (86.7% similar) in 444 aa overlap (1-444:1-399) 10 20 30 40 50 60 pF1KB8 MDEEYDVIVLGTGLTECILSGIMSVNGKKVLHMDRNPYYGGESSSITPLEELYKRFQLLE :.:::::::::::::::::::::::::::::::::::::::::.::::::.:::::.. CCDS44 MNEEYDVIVLGTGLTECILSGIMSVNGKKVLHMDRNPYYGGESASITPLEDLYKRFKIPG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 GPPESMGRGRDWNVDLIPKFLMANGQLVKMLLYTEVTRYLDFKVVEGSFVYKGGKIYKVP .:::::::::::::::::::::::: CCDS44 SPPESMGRGRDWNVDLIPKFLMANG----------------------------------- 70 80 130 140 150 160 170 180 pF1KB8 STETEALASNLMGMFEKRRFRKFLVFVANFDENDPKTFEGVDPQTTSMRDVYRKFDLGQD :::.:::::::::::.::::::.::.::::.::. :.:::::.::::::: CCDS44 ----------LMGLFEKRRFRKFLVYVANFDEKDPRTFEGIDPKKTTMRDVYKKFDLGQD 90 100 110 120 130 190 200 210 220 230 240 pF1KB8 VIDFTGHALALYRTDDYLDQPCLETVNRIKLYSESLARYGKSPYLYPLYGLGELPQGFAR :::::::::::::::::::::: ::.:::::::::::::::::::::::::::::::::: CCDS44 VIDFTGHALALYRTDDYLDQPCYETINRIKLYSESLARYGKSPYLYPLYGLGELPQGFAR 140 150 160 170 180 190 250 260 270 280 290 300 pF1KB8 LSAIYGGTYMLNKPVDDIIMENGKVVGVKSEGEVARCKQLICDPSYIPDRVRKAGQVIRI ::::::::::::::...::..::::.:::::::.::::::::::::. :::.:.:::::. CCDS44 LSAIYGGTYMLNKPIEEIIVQNGKVIGVKSEGEIARCKQLICDPSYVKDRVEKVGQVIRV 200 210 220 230 240 250 310 320 330 340 350 360 pF1KB8 ICILSHPIKNTNDANSCQIIIPQNQVNRKSDIYVCMISYAHNVAAQGKYIAIASTTVETT ::::::::::::::::::::::::::::::::::::::.:::::::::::::.:::::: CCDS44 ICILSHPIKNTNDANSCQIIIPQNQVNRKSDIYVCMISFAHNVAAQGKYIAIVSTTVETK 260 270 280 290 300 310 370 380 390 400 410 420 pF1KB8 DPEKEVEPALELLEPIDQKFVAISDLYEPIDDGCESQVFCSCSYDATTHFETTCNDIKDI .::::..:::::::::.::::.:::: : : : :::.: : .:::::::::::.:::.: CCDS44 EPEKEIRPALELLEPIEQKFVSISDLLVPKDLGTESQIFISRTYDATTHFETTCDDIKNI 320 330 340 350 360 370 430 440 pF1KB8 YKRMAGTAFDFENMKRKQNDVFGEAEQ ::::.:. ::::.::::.::..:: CCDS44 YKRMTGSEFDFEEMKRKKNDIYGED 380 390 400 >>CCDS31073.1 CHML gene_id:1122|Hs108|chr1 (656 aa) initn: 456 init1: 213 opt: 435 Z-score: 545.0 bits: 110.6 E(32554): 4.9e-24 Smith-Waterman score: 435; 25.1% identity (60.4% similar) in 331 aa overlap (69-389:226-546) 40 50 60 70 80 90 pF1KB8 YGGESSSITPLEELYKRFQLLEGPPESMGRGRDWNVDLIPKFLMANGQLVKMLLYTEVTR :: .:.::. :.:...: :. .:. ..:.: CCDS31 GDKDESKSTVEDKADEPIRNRITYSQIVKEGRRFNIDLVSKLLYSQGLLIDLLIKSDVSR 200 210 220 230 240 250 100 110 120 130 140 150 pF1KB8 YLDFKVVEGSFVYKGGKIYKVPSTETEALASNLMGMFEKRRFRKFLVFVANFDENDPKTF :..:: : .... ::. .:: ...... :. . : ::: . :::.: ..... : . CCDS31 YVEFKNVTRILAFREGKVEQVPCSRADVFNSKELTMVEKRMLMKFLTFCLEYEQH-PDEY 260 270 280 290 300 310 160 170 180 190 200 210 pF1KB8 EGVDPQTTSMRDVYRKFDLGQDVIDFTGHALALYRTDDYLDQPC--LETVNRIKLYSESL .. . :. . . : .. :. :..:. .. : .. .: : . . : CCDS31 QAF--RQCSFSEYLKTKKLTPNLQHFVLHSIAMTS-----ESSCTTIDGLNATKNFLQCL 320 330 340 350 360 220 230 240 250 260 270 pF1KB8 ARYGKSPYLYPLYGLGELPQGFARLSAIYGGTYMLNKPVDDIIM--ENGKVVGVKSE-GE .:.:..:.:.:::: ::.:::: :. :..:: : : . :. ... :.:. .. .. :. CCDS31 GRFGNTPFLFPLYGQGEIPQGFCRMCAVFGGIYCLRHKVQCFVVDKESGRCKAIIDHFGQ 370 380 390 400 410 420 280 290 300 310 320 pF1KB8 VARCKQLICDPSYIPDRV---RKAGQVIRIICILSHPIKNTN-DANSCQIIIPQNQVNRK : .: . ::. ... . :. : . : .. : .:. : .. .:.: . . CCDS31 RINAKYFIVEDSYLSEETCSNVQYKQISRAVLITDQSILKTDLDQQTSILIVPPAEPG-A 430 440 450 460 470 480 330 340 350 360 370 380 pF1KB8 SDIYVCMISYAHNVAAQGKYIAIASTTVETTDPEKEVEPALE-LLEPIDQKFVAISDLYE . : . . . . :. . : . ....: ... :. : . . .: . CCDS31 CAVRVTELCSSTMTCMKDTYL-VHLTCSSSKTAREDLESVVKKLFTPYTETEINEEELTK 490 500 510 520 530 540 390 400 410 420 430 440 pF1KB8 PIDDGCESQVFCSCSYDATTHFETTCNDIKDIYKRMAGTAFDFENMKRKQNDVFGEAEQ : CCDS31 PRLLWALYFNMRDSSGISRSSYNGLPSNVYVCSGPDCGLGNEHAVKQAETLFQEIFPTEE 550 560 570 580 590 600 >>CCDS14454.1 CHM gene_id:1121|Hs108|chrX (653 aa) initn: 498 init1: 203 opt: 399 Z-score: 499.6 bits: 102.2 E(32554): 1.7e-21 Smith-Waterman score: 399; 26.0% identity (59.9% similar) in 327 aa overlap (69-386:224-534) 40 50 60 70 80 90 pF1KB8 YGGESSSITPLEELYKRFQLLEGPPESMGRGRDWNVDLIPKFLMANGQLVKMLLYTEVTR :: .:.::. :.:.. : :. .:. ..:.: CCDS14 EDMSENVPIAEDTTEQPKKNRITYSQIIKEGRRFNIDLVSKLLYSRGLLIDLLIKSNVSR 200 210 220 230 240 250 100 110 120 130 140 150 pF1KB8 YLDFKVVEGSFVYKGGKIYKVPSTETEALASNLMGMFEKRRFRKFLVFVANFDENDPKTF : .:: . .... :.. .:: ...... :. . : ::: . :::.: .. :. : . CCDS14 YAEFKNITRILAFREGRVEQVPCSRADVFNSKQLTMVEKRMLMKFLTFCMEY-EKYPDEY 260 270 280 290 300 310 160 170 180 190 200 210 pF1KB8 EGVDPQTTSMRDVYRKFDLGQDVIDFTGHALALYRTDDYLDQPCLETVNRIKLYSESLAR .: . : . . . : .. .. :..:. . . .. .. : . . :.: CCDS14 KGYEEIT--FYEYLKTQKLTPNLQYIVMHSIAM---TSETASSTIDGLKATKNFLHCLGR 320 330 340 350 360 220 230 240 250 260 270 pF1KB8 YGKSPYLYPLYGLGELPQGFARLSAIYGGTYMLNKPVDDIIM--ENGKVVGVKSE-GEVA ::..:.:.:::: ::::: : :. :..:: : : . :. ... :. : .. .. :. CCDS14 YGNTPFLFPLYGQGELPQCFCRMCAVFGGIYCLRHSVQCLVVDKESRKCKAIIDQFGQRI 370 380 390 400 410 420 280 290 300 310 320 330 pF1KB8 RCKQLICDPSYIPD----RVRKAGQVIRIICILSHPIKNTNDANSCQII-IPQNQVNRKS .... . ::.:. :: . :. : . : .. . .:.. .. .:. .: .. . . CCDS14 ISEHFLVEDSYFPENMCSRV-QYRQISRAVLITDRSVLKTDSDQQISILTVPAEEPGTFA 430 440 450 460 470 480 340 350 360 370 380 pF1KB8 DIYVCMISYAHNVAAQGKYIAIASTTVETTDPEKEVEPALELLEPIDQK-FVAISDLYEP . : . . . .: :.. . : : : : :: . :: :: ... CCDS14 -VRVIELCSSTMTCMKGTYLVHLTCTSSKT--------AREDLESVVQKLFVPYTEMEIE 490 500 510 520 530 390 400 410 420 430 440 pF1KB8 IDDGCESQVFCSCSYDATTHFETTCNDIKDIYKRMAGTAFDFENMKRKQNDVFGEAEQ CCDS14 NEQVEKPRILWALYFNMRDSSDISRSCYNDLPSNVYVCSGPDCGLGNDNAVKQAETLFQE 540 550 560 570 580 590 447 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 09:28:17 2016 done: Fri Nov 4 09:28:18 2016 Total Scan time: 2.750 Total Display time: 0.020 Function used was FASTA [36.3.4 Apr, 2011]