FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8101, 447 aa 1>>>pF1KB8101 447 - 447 aa - 447 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.2393+/-0.000455; mu= 17.7572+/- 0.028 mean_var=65.8199+/-12.959, 0's: 0 Z-trim(109.0): 37 B-trim: 0 in 0/53 Lambda= 0.158087 statistics sampled from 17089 (17115) to 17089 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.566), E-opt: 0.2 (0.201), width: 16 Scan time: 6.180 The best scores are: opt bits E(85289) NP_001484 (OMIM: 300104,300849) rab GDP dissociati ( 447) 2986 690.4 2.5e-198 NP_001485 (OMIM: 600767) rab GDP dissociation inhi ( 445) 2642 612.0 1e-174 XP_016871560 (OMIM: 600767) PREDICTED: rab GDP dis ( 423) 2507 581.2 1.8e-165 NP_001108628 (OMIM: 600767) rab GDP dissociation i ( 400) 1864 434.5 2.4e-121 NP_001812 (OMIM: 118825) rab proteins geranylgeran ( 656) 435 108.7 4.7e-23 XP_016884732 (OMIM: 300390,303100) PREDICTED: rab ( 505) 399 100.4 1.1e-20 XP_016884735 (OMIM: 300390,303100) PREDICTED: rab ( 505) 399 100.4 1.1e-20 NP_001307888 (OMIM: 300390,303100) rab proteins ge ( 505) 399 100.4 1.1e-20 XP_016884734 (OMIM: 300390,303100) PREDICTED: rab ( 505) 399 100.4 1.1e-20 XP_016884733 (OMIM: 300390,303100) PREDICTED: rab ( 505) 399 100.4 1.1e-20 XP_016884731 (OMIM: 300390,303100) PREDICTED: rab ( 602) 399 100.5 1.3e-20 NP_000381 (OMIM: 300390,303100) rab proteins geran ( 653) 399 100.5 1.4e-20 NP_001138886 (OMIM: 300390,303100) rab proteins ge ( 110) 154 44.2 0.00021 >>NP_001484 (OMIM: 300104,300849) rab GDP dissociation i (447 aa) initn: 2986 init1: 2986 opt: 2986 Z-score: 3681.8 bits: 690.4 E(85289): 2.5e-198 Smith-Waterman score: 2986; 100.0% identity (100.0% similar) in 447 aa overlap (1-447:1-447) 10 20 30 40 50 60 pF1KB8 MDEEYDVIVLGTGLTECILSGIMSVNGKKVLHMDRNPYYGGESSSITPLEELYKRFQLLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MDEEYDVIVLGTGLTECILSGIMSVNGKKVLHMDRNPYYGGESSSITPLEELYKRFQLLE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 GPPESMGRGRDWNVDLIPKFLMANGQLVKMLLYTEVTRYLDFKVVEGSFVYKGGKIYKVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GPPESMGRGRDWNVDLIPKFLMANGQLVKMLLYTEVTRYLDFKVVEGSFVYKGGKIYKVP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 STETEALASNLMGMFEKRRFRKFLVFVANFDENDPKTFEGVDPQTTSMRDVYRKFDLGQD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 STETEALASNLMGMFEKRRFRKFLVFVANFDENDPKTFEGVDPQTTSMRDVYRKFDLGQD 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 VIDFTGHALALYRTDDYLDQPCLETVNRIKLYSESLARYGKSPYLYPLYGLGELPQGFAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VIDFTGHALALYRTDDYLDQPCLETVNRIKLYSESLARYGKSPYLYPLYGLGELPQGFAR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 LSAIYGGTYMLNKPVDDIIMENGKVVGVKSEGEVARCKQLICDPSYIPDRVRKAGQVIRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LSAIYGGTYMLNKPVDDIIMENGKVVGVKSEGEVARCKQLICDPSYIPDRVRKAGQVIRI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 ICILSHPIKNTNDANSCQIIIPQNQVNRKSDIYVCMISYAHNVAAQGKYIAIASTTVETT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ICILSHPIKNTNDANSCQIIIPQNQVNRKSDIYVCMISYAHNVAAQGKYIAIASTTVETT 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 DPEKEVEPALELLEPIDQKFVAISDLYEPIDDGCESQVFCSCSYDATTHFETTCNDIKDI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DPEKEVEPALELLEPIDQKFVAISDLYEPIDDGCESQVFCSCSYDATTHFETTCNDIKDI 370 380 390 400 410 420 430 440 pF1KB8 YKRMAGTAFDFENMKRKQNDVFGEAEQ ::::::::::::::::::::::::::: NP_001 YKRMAGTAFDFENMKRKQNDVFGEAEQ 430 440 >>NP_001485 (OMIM: 600767) rab GDP dissociation inhibito (445 aa) initn: 2642 init1: 2642 opt: 2642 Z-score: 3257.8 bits: 612.0 E(85289): 1e-174 Smith-Waterman score: 2642; 86.5% identity (96.8% similar) in 444 aa overlap (1-444:1-444) 10 20 30 40 50 60 pF1KB8 MDEEYDVIVLGTGLTECILSGIMSVNGKKVLHMDRNPYYGGESSSITPLEELYKRFQLLE :.:::::::::::::::::::::::::::::::::::::::::.::::::.:::::.. NP_001 MNEEYDVIVLGTGLTECILSGIMSVNGKKVLHMDRNPYYGGESASITPLEDLYKRFKIPG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 GPPESMGRGRDWNVDLIPKFLMANGQLVKMLLYTEVTRYLDFKVVEGSFVYKGGKIYKVP .:::::::::::::::::::::::::::::::::::::::::::.::::::::::::::: NP_001 SPPESMGRGRDWNVDLIPKFLMANGQLVKMLLYTEVTRYLDFKVTEGSFVYKGGKIYKVP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 STETEALASNLMGMFEKRRFRKFLVFVANFDENDPKTFEGVDPQTTSMRDVYRKFDLGQD :::.:::::.:::.:::::::::::.::::::.::.::::.::. :.:::::.::::::: NP_001 STEAEALASSLMGLFEKRRFRKFLVYVANFDEKDPRTFEGIDPKKTTMRDVYKKFDLGQD 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 VIDFTGHALALYRTDDYLDQPCLETVNRIKLYSESLARYGKSPYLYPLYGLGELPQGFAR :::::::::::::::::::::: ::.:::::::::::::::::::::::::::::::::: NP_001 VIDFTGHALALYRTDDYLDQPCYETINRIKLYSESLARYGKSPYLYPLYGLGELPQGFAR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 LSAIYGGTYMLNKPVDDIIMENGKVVGVKSEGEVARCKQLICDPSYIPDRVRKAGQVIRI ::::::::::::::...::..::::.:::::::.::::::::::::. :::.:.:::::. NP_001 LSAIYGGTYMLNKPIEEIIVQNGKVIGVKSEGEIARCKQLICDPSYVKDRVEKVGQVIRV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 ICILSHPIKNTNDANSCQIIIPQNQVNRKSDIYVCMISYAHNVAAQGKYIAIASTTVETT ::::::::::::::::::::::::::::::::::::::.:::::::::::::.:::::: NP_001 ICILSHPIKNTNDANSCQIIIPQNQVNRKSDIYVCMISFAHNVAAQGKYIAIVSTTVETK 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 DPEKEVEPALELLEPIDQKFVAISDLYEPIDDGCESQVFCSCSYDATTHFETTCNDIKDI .::::..:::::::::.::::.:::: : : : :::.: : .:::::::::::.:::.: NP_001 EPEKEIRPALELLEPIEQKFVSISDLLVPKDLGTESQIFISRTYDATTHFETTCDDIKNI 370 380 390 400 410 420 430 440 pF1KB8 YKRMAGTAFDFENMKRKQNDVFGEAEQ ::::.:. ::::.::::.::..:: NP_001 YKRMTGSEFDFEEMKRKKNDIYGED 430 440 >>XP_016871560 (OMIM: 600767) PREDICTED: rab GDP dissoci (423 aa) initn: 2507 init1: 2507 opt: 2507 Z-score: 3091.7 bits: 581.2 E(85289): 1.8e-165 Smith-Waterman score: 2507; 86.0% identity (96.7% similar) in 422 aa overlap (23-444:1-422) 10 20 30 40 50 60 pF1KB8 MDEEYDVIVLGTGLTECILSGIMSVNGKKVLHMDRNPYYGGESSSITPLEELYKRFQLLE :::::::::::::::::::::.::::::.:::::.. XP_016 MSVNGKKVLHMDRNPYYGGESASITPLEDLYKRFKIPG 10 20 30 70 80 90 100 110 120 pF1KB8 GPPESMGRGRDWNVDLIPKFLMANGQLVKMLLYTEVTRYLDFKVVEGSFVYKGGKIYKVP .:::::::::::::::::::::::::::::::::::::::::::.::::::::::::::: XP_016 SPPESMGRGRDWNVDLIPKFLMANGQLVKMLLYTEVTRYLDFKVTEGSFVYKGGKIYKVP 40 50 60 70 80 90 130 140 150 160 170 180 pF1KB8 STETEALASNLMGMFEKRRFRKFLVFVANFDENDPKTFEGVDPQTTSMRDVYRKFDLGQD :::.:::::.:::.:::::::::::.::::::.::.::::.::. :.:::::.::::::: XP_016 STEAEALASSLMGLFEKRRFRKFLVYVANFDEKDPRTFEGIDPKKTTMRDVYKKFDLGQD 100 110 120 130 140 150 190 200 210 220 230 240 pF1KB8 VIDFTGHALALYRTDDYLDQPCLETVNRIKLYSESLARYGKSPYLYPLYGLGELPQGFAR :::::::::::::::::::::: ::.:::::::::::::::::::::::::::::::::: XP_016 VIDFTGHALALYRTDDYLDQPCYETINRIKLYSESLARYGKSPYLYPLYGLGELPQGFAR 160 170 180 190 200 210 250 260 270 280 290 300 pF1KB8 LSAIYGGTYMLNKPVDDIIMENGKVVGVKSEGEVARCKQLICDPSYIPDRVRKAGQVIRI ::::::::::::::...::..::::.:::::::.::::::::::::. :::.:.:::::. XP_016 LSAIYGGTYMLNKPIEEIIVQNGKVIGVKSEGEIARCKQLICDPSYVKDRVEKVGQVIRV 220 230 240 250 260 270 310 320 330 340 350 360 pF1KB8 ICILSHPIKNTNDANSCQIIIPQNQVNRKSDIYVCMISYAHNVAAQGKYIAIASTTVETT ::::::::::::::::::::::::::::::::::::::.:::::::::::::.:::::: XP_016 ICILSHPIKNTNDANSCQIIIPQNQVNRKSDIYVCMISFAHNVAAQGKYIAIVSTTVETK 280 290 300 310 320 330 370 380 390 400 410 420 pF1KB8 DPEKEVEPALELLEPIDQKFVAISDLYEPIDDGCESQVFCSCSYDATTHFETTCNDIKDI .::::..:::::::::.::::.:::: : : : :::.: : .:::::::::::.:::.: XP_016 EPEKEIRPALELLEPIEQKFVSISDLLVPKDLGTESQIFISRTYDATTHFETTCDDIKNI 340 350 360 370 380 390 430 440 pF1KB8 YKRMAGTAFDFENMKRKQNDVFGEAEQ ::::.:. ::::.::::.::..:: XP_016 YKRMTGSEFDFEEMKRKKNDIYGED 400 410 420 >>NP_001108628 (OMIM: 600767) rab GDP dissociation inhib (400 aa) initn: 1862 init1: 1862 opt: 1864 Z-score: 2299.5 bits: 434.5 E(85289): 2.4e-121 Smith-Waterman score: 2281; 77.0% identity (86.7% similar) in 444 aa overlap (1-444:1-399) 10 20 30 40 50 60 pF1KB8 MDEEYDVIVLGTGLTECILSGIMSVNGKKVLHMDRNPYYGGESSSITPLEELYKRFQLLE :.:::::::::::::::::::::::::::::::::::::::::.::::::.:::::.. NP_001 MNEEYDVIVLGTGLTECILSGIMSVNGKKVLHMDRNPYYGGESASITPLEDLYKRFKIPG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 GPPESMGRGRDWNVDLIPKFLMANGQLVKMLLYTEVTRYLDFKVVEGSFVYKGGKIYKVP .:::::::::::::::::::::::: NP_001 SPPESMGRGRDWNVDLIPKFLMANG----------------------------------- 70 80 130 140 150 160 170 180 pF1KB8 STETEALASNLMGMFEKRRFRKFLVFVANFDENDPKTFEGVDPQTTSMRDVYRKFDLGQD :::.:::::::::::.::::::.::.::::.::. :.:::::.::::::: NP_001 ----------LMGLFEKRRFRKFLVYVANFDEKDPRTFEGIDPKKTTMRDVYKKFDLGQD 90 100 110 120 130 190 200 210 220 230 240 pF1KB8 VIDFTGHALALYRTDDYLDQPCLETVNRIKLYSESLARYGKSPYLYPLYGLGELPQGFAR :::::::::::::::::::::: ::.:::::::::::::::::::::::::::::::::: NP_001 VIDFTGHALALYRTDDYLDQPCYETINRIKLYSESLARYGKSPYLYPLYGLGELPQGFAR 140 150 160 170 180 190 250 260 270 280 290 300 pF1KB8 LSAIYGGTYMLNKPVDDIIMENGKVVGVKSEGEVARCKQLICDPSYIPDRVRKAGQVIRI ::::::::::::::...::..::::.:::::::.::::::::::::. :::.:.:::::. NP_001 LSAIYGGTYMLNKPIEEIIVQNGKVIGVKSEGEIARCKQLICDPSYVKDRVEKVGQVIRV 200 210 220 230 240 250 310 320 330 340 350 360 pF1KB8 ICILSHPIKNTNDANSCQIIIPQNQVNRKSDIYVCMISYAHNVAAQGKYIAIASTTVETT ::::::::::::::::::::::::::::::::::::::.:::::::::::::.:::::: NP_001 ICILSHPIKNTNDANSCQIIIPQNQVNRKSDIYVCMISFAHNVAAQGKYIAIVSTTVETK 260 270 280 290 300 310 370 380 390 400 410 420 pF1KB8 DPEKEVEPALELLEPIDQKFVAISDLYEPIDDGCESQVFCSCSYDATTHFETTCNDIKDI .::::..:::::::::.::::.:::: : : : :::.: : .:::::::::::.:::.: NP_001 EPEKEIRPALELLEPIEQKFVSISDLLVPKDLGTESQIFISRTYDATTHFETTCDDIKNI 320 330 340 350 360 370 430 440 pF1KB8 YKRMAGTAFDFENMKRKQNDVFGEAEQ ::::.:. ::::.::::.::..:: NP_001 YKRMTGSEFDFEEMKRKKNDIYGED 380 390 400 >>NP_001812 (OMIM: 118825) rab proteins geranylgeranyltr (656 aa) initn: 456 init1: 213 opt: 435 Z-score: 534.9 bits: 108.7 E(85289): 4.7e-23 Smith-Waterman score: 435; 25.1% identity (60.4% similar) in 331 aa overlap (69-389:226-546) 40 50 60 70 80 90 pF1KB8 YGGESSSITPLEELYKRFQLLEGPPESMGRGRDWNVDLIPKFLMANGQLVKMLLYTEVTR :: .:.::. :.:...: :. .:. ..:.: NP_001 GDKDESKSTVEDKADEPIRNRITYSQIVKEGRRFNIDLVSKLLYSQGLLIDLLIKSDVSR 200 210 220 230 240 250 100 110 120 130 140 150 pF1KB8 YLDFKVVEGSFVYKGGKIYKVPSTETEALASNLMGMFEKRRFRKFLVFVANFDENDPKTF :..:: : .... ::. .:: ...... :. . : ::: . :::.: ..... : . NP_001 YVEFKNVTRILAFREGKVEQVPCSRADVFNSKELTMVEKRMLMKFLTFCLEYEQH-PDEY 260 270 280 290 300 310 160 170 180 190 200 210 pF1KB8 EGVDPQTTSMRDVYRKFDLGQDVIDFTGHALALYRTDDYLDQPC--LETVNRIKLYSESL .. . :. . . : .. :. :..:. .. : .. .: : . . : NP_001 QAF--RQCSFSEYLKTKKLTPNLQHFVLHSIAMTS-----ESSCTTIDGLNATKNFLQCL 320 330 340 350 360 220 230 240 250 260 270 pF1KB8 ARYGKSPYLYPLYGLGELPQGFARLSAIYGGTYMLNKPVDDIIM--ENGKVVGVKSE-GE .:.:..:.:.:::: ::.:::: :. :..:: : : . :. ... :.:. .. .. :. NP_001 GRFGNTPFLFPLYGQGEIPQGFCRMCAVFGGIYCLRHKVQCFVVDKESGRCKAIIDHFGQ 370 380 390 400 410 420 280 290 300 310 320 pF1KB8 VARCKQLICDPSYIPDRV---RKAGQVIRIICILSHPIKNTN-DANSCQIIIPQNQVNRK : .: . ::. ... . :. : . : .. : .:. : .. .:.: . . NP_001 RINAKYFIVEDSYLSEETCSNVQYKQISRAVLITDQSILKTDLDQQTSILIVPPAEPG-A 430 440 450 460 470 480 330 340 350 360 370 380 pF1KB8 SDIYVCMISYAHNVAAQGKYIAIASTTVETTDPEKEVEPALE-LLEPIDQKFVAISDLYE . : . . . . :. . : . ....: ... :. : . . .: . NP_001 CAVRVTELCSSTMTCMKDTYL-VHLTCSSSKTAREDLESVVKKLFTPYTETEINEEELTK 490 500 510 520 530 540 390 400 410 420 430 440 pF1KB8 PIDDGCESQVFCSCSYDATTHFETTCNDIKDIYKRMAGTAFDFENMKRKQNDVFGEAEQ : NP_001 PRLLWALYFNMRDSSGISRSSYNGLPSNVYVCSGPDCGLGNEHAVKQAETLFQEIFPTEE 550 560 570 580 590 600 >>XP_016884732 (OMIM: 300390,303100) PREDICTED: rab prot (505 aa) initn: 362 init1: 203 opt: 399 Z-score: 492.2 bits: 100.4 E(85289): 1.1e-20 Smith-Waterman score: 399; 26.0% identity (59.9% similar) in 327 aa overlap (69-386:76-386) 40 50 60 70 80 90 pF1KB8 YGGESSSITPLEELYKRFQLLEGPPESMGRGRDWNVDLIPKFLMANGQLVKMLLYTEVTR :: .:.::. :.:.. : :. .:. ..:.: XP_016 EDMSENVPIAEDTTEQPKKNRITYSQIIKEGRRFNIDLVSKLLYSRGLLIDLLIKSNVSR 50 60 70 80 90 100 100 110 120 130 140 150 pF1KB8 YLDFKVVEGSFVYKGGKIYKVPSTETEALASNLMGMFEKRRFRKFLVFVANFDENDPKTF : .:: . .... :.. .:: ...... :. . : ::: . :::.: .. :. : . XP_016 YAEFKNITRILAFREGRVEQVPCSRADVFNSKQLTMVEKRMLMKFLTFCMEY-EKYPDEY 110 120 130 140 150 160 160 170 180 190 200 210 pF1KB8 EGVDPQTTSMRDVYRKFDLGQDVIDFTGHALALYRTDDYLDQPCLETVNRIKLYSESLAR .: . : . . . : .. .. :..:. . . .. .. : . . :.: XP_016 KGYEEIT--FYEYLKTQKLTPNLQYIVMHSIAM---TSETASSTIDGLKATKNFLHCLGR 170 180 190 200 210 220 230 240 250 260 270 pF1KB8 YGKSPYLYPLYGLGELPQGFARLSAIYGGTYMLNKPVDDIIM--ENGKVVGVKSE-GEVA ::..:.:.:::: ::::: : :. :..:: : : . :. ... :. : .. .. :. XP_016 YGNTPFLFPLYGQGELPQCFCRMCAVFGGIYCLRHSVQCLVVDKESRKCKAIIDQFGQRI 220 230 240 250 260 270 280 290 300 310 320 330 pF1KB8 RCKQLICDPSYIPD----RVRKAGQVIRIICILSHPIKNTNDANSCQII-IPQNQVNRKS .... . ::.:. :: . :. : . : .. . .:.. .. .:. .: .. . . XP_016 ISEHFLVEDSYFPENMCSRV-QYRQISRAVLITDRSVLKTDSDQQISILTVPAEEPGTFA 280 290 300 310 320 330 340 350 360 370 380 pF1KB8 DIYVCMISYAHNVAAQGKYIAIASTTVETTDPEKEVEPALELLEPIDQK-FVAISDLYEP . : . . . .: :.. . : : : : :: . :: :: ... XP_016 -VRVIELCSSTMTCMKGTYLVHLTCTSSKT--------AREDLESVVQKLFVPYTEMEIE 340 350 360 370 380 390 400 410 420 430 440 pF1KB8 IDDGCESQVFCSCSYDATTHFETTCNDIKDIYKRMAGTAFDFENMKRKQNDVFGEAEQ XP_016 NEQVEKPRILWALYFNMRDSSDISRSCYNDLPSNVYVCSGPDCGLGNDNAVKQAETLFQE 390 400 410 420 430 440 >>XP_016884735 (OMIM: 300390,303100) PREDICTED: rab prot (505 aa) initn: 362 init1: 203 opt: 399 Z-score: 492.2 bits: 100.4 E(85289): 1.1e-20 Smith-Waterman score: 399; 26.0% identity (59.9% similar) in 327 aa overlap (69-386:76-386) 40 50 60 70 80 90 pF1KB8 YGGESSSITPLEELYKRFQLLEGPPESMGRGRDWNVDLIPKFLMANGQLVKMLLYTEVTR :: .:.::. :.:.. : :. .:. ..:.: XP_016 EDMSENVPIAEDTTEQPKKNRITYSQIIKEGRRFNIDLVSKLLYSRGLLIDLLIKSNVSR 50 60 70 80 90 100 100 110 120 130 140 150 pF1KB8 YLDFKVVEGSFVYKGGKIYKVPSTETEALASNLMGMFEKRRFRKFLVFVANFDENDPKTF : .:: . .... :.. .:: ...... :. . : ::: . :::.: .. :. : . XP_016 YAEFKNITRILAFREGRVEQVPCSRADVFNSKQLTMVEKRMLMKFLTFCMEY-EKYPDEY 110 120 130 140 150 160 160 170 180 190 200 210 pF1KB8 EGVDPQTTSMRDVYRKFDLGQDVIDFTGHALALYRTDDYLDQPCLETVNRIKLYSESLAR .: . : . . . : .. .. :..:. . . .. .. : . . :.: XP_016 KGYEEIT--FYEYLKTQKLTPNLQYIVMHSIAM---TSETASSTIDGLKATKNFLHCLGR 170 180 190 200 210 220 230 240 250 260 270 pF1KB8 YGKSPYLYPLYGLGELPQGFARLSAIYGGTYMLNKPVDDIIM--ENGKVVGVKSE-GEVA ::..:.:.:::: ::::: : :. :..:: : : . :. ... :. : .. .. :. XP_016 YGNTPFLFPLYGQGELPQCFCRMCAVFGGIYCLRHSVQCLVVDKESRKCKAIIDQFGQRI 220 230 240 250 260 270 280 290 300 310 320 330 pF1KB8 RCKQLICDPSYIPD----RVRKAGQVIRIICILSHPIKNTNDANSCQII-IPQNQVNRKS .... . ::.:. :: . :. : . : .. . .:.. .. .:. .: .. . . XP_016 ISEHFLVEDSYFPENMCSRV-QYRQISRAVLITDRSVLKTDSDQQISILTVPAEEPGTFA 280 290 300 310 320 330 340 350 360 370 380 pF1KB8 DIYVCMISYAHNVAAQGKYIAIASTTVETTDPEKEVEPALELLEPIDQK-FVAISDLYEP . : . . . .: :.. . : : : : :: . :: :: ... XP_016 -VRVIELCSSTMTCMKGTYLVHLTCTSSKT--------AREDLESVVQKLFVPYTEMEIE 340 350 360 370 380 390 400 410 420 430 440 pF1KB8 IDDGCESQVFCSCSYDATTHFETTCNDIKDIYKRMAGTAFDFENMKRKQNDVFGEAEQ XP_016 NEQVEKPRILWALYFNMRDSSDISRSCYNDLPSNVYVCSGPDCGLGNDNAVKQAETLFQE 390 400 410 420 430 440 >>NP_001307888 (OMIM: 300390,303100) rab proteins gerany (505 aa) initn: 362 init1: 203 opt: 399 Z-score: 492.2 bits: 100.4 E(85289): 1.1e-20 Smith-Waterman score: 399; 26.0% identity (59.9% similar) in 327 aa overlap (69-386:76-386) 40 50 60 70 80 90 pF1KB8 YGGESSSITPLEELYKRFQLLEGPPESMGRGRDWNVDLIPKFLMANGQLVKMLLYTEVTR :: .:.::. :.:.. : :. .:. ..:.: NP_001 EDMSENVPIAEDTTEQPKKNRITYSQIIKEGRRFNIDLVSKLLYSRGLLIDLLIKSNVSR 50 60 70 80 90 100 100 110 120 130 140 150 pF1KB8 YLDFKVVEGSFVYKGGKIYKVPSTETEALASNLMGMFEKRRFRKFLVFVANFDENDPKTF : .:: . .... :.. .:: ...... :. . : ::: . :::.: .. :. : . NP_001 YAEFKNITRILAFREGRVEQVPCSRADVFNSKQLTMVEKRMLMKFLTFCMEY-EKYPDEY 110 120 130 140 150 160 160 170 180 190 200 210 pF1KB8 EGVDPQTTSMRDVYRKFDLGQDVIDFTGHALALYRTDDYLDQPCLETVNRIKLYSESLAR .: . : . . . : .. .. :..:. . . .. .. : . . :.: NP_001 KGYEEIT--FYEYLKTQKLTPNLQYIVMHSIAM---TSETASSTIDGLKATKNFLHCLGR 170 180 190 200 210 220 230 240 250 260 270 pF1KB8 YGKSPYLYPLYGLGELPQGFARLSAIYGGTYMLNKPVDDIIM--ENGKVVGVKSE-GEVA ::..:.:.:::: ::::: : :. :..:: : : . :. ... :. : .. .. :. NP_001 YGNTPFLFPLYGQGELPQCFCRMCAVFGGIYCLRHSVQCLVVDKESRKCKAIIDQFGQRI 220 230 240 250 260 270 280 290 300 310 320 330 pF1KB8 RCKQLICDPSYIPD----RVRKAGQVIRIICILSHPIKNTNDANSCQII-IPQNQVNRKS .... . ::.:. :: . :. : . : .. . .:.. .. .:. .: .. . . NP_001 ISEHFLVEDSYFPENMCSRV-QYRQISRAVLITDRSVLKTDSDQQISILTVPAEEPGTFA 280 290 300 310 320 330 340 350 360 370 380 pF1KB8 DIYVCMISYAHNVAAQGKYIAIASTTVETTDPEKEVEPALELLEPIDQK-FVAISDLYEP . : . . . .: :.. . : : : : :: . :: :: ... NP_001 -VRVIELCSSTMTCMKGTYLVHLTCTSSKT--------AREDLESVVQKLFVPYTEMEIE 340 350 360 370 380 390 400 410 420 430 440 pF1KB8 IDDGCESQVFCSCSYDATTHFETTCNDIKDIYKRMAGTAFDFENMKRKQNDVFGEAEQ NP_001 NEQVEKPRILWALYFNMRDSSDISRSCYNDLPSNVYVCSGPDCGLGNDNAVKQAETLFQE 390 400 410 420 430 440 >>XP_016884734 (OMIM: 300390,303100) PREDICTED: rab prot (505 aa) initn: 362 init1: 203 opt: 399 Z-score: 492.2 bits: 100.4 E(85289): 1.1e-20 Smith-Waterman score: 399; 26.0% identity (59.9% similar) in 327 aa overlap (69-386:76-386) 40 50 60 70 80 90 pF1KB8 YGGESSSITPLEELYKRFQLLEGPPESMGRGRDWNVDLIPKFLMANGQLVKMLLYTEVTR :: .:.::. :.:.. : :. .:. ..:.: XP_016 EDMSENVPIAEDTTEQPKKNRITYSQIIKEGRRFNIDLVSKLLYSRGLLIDLLIKSNVSR 50 60 70 80 90 100 100 110 120 130 140 150 pF1KB8 YLDFKVVEGSFVYKGGKIYKVPSTETEALASNLMGMFEKRRFRKFLVFVANFDENDPKTF : .:: . .... :.. .:: ...... :. . : ::: . :::.: .. :. : . XP_016 YAEFKNITRILAFREGRVEQVPCSRADVFNSKQLTMVEKRMLMKFLTFCMEY-EKYPDEY 110 120 130 140 150 160 160 170 180 190 200 210 pF1KB8 EGVDPQTTSMRDVYRKFDLGQDVIDFTGHALALYRTDDYLDQPCLETVNRIKLYSESLAR .: . : . . . : .. .. :..:. . . .. .. : . . :.: XP_016 KGYEEIT--FYEYLKTQKLTPNLQYIVMHSIAM---TSETASSTIDGLKATKNFLHCLGR 170 180 190 200 210 220 230 240 250 260 270 pF1KB8 YGKSPYLYPLYGLGELPQGFARLSAIYGGTYMLNKPVDDIIM--ENGKVVGVKSE-GEVA ::..:.:.:::: ::::: : :. :..:: : : . :. ... :. : .. .. :. XP_016 YGNTPFLFPLYGQGELPQCFCRMCAVFGGIYCLRHSVQCLVVDKESRKCKAIIDQFGQRI 220 230 240 250 260 270 280 290 300 310 320 330 pF1KB8 RCKQLICDPSYIPD----RVRKAGQVIRIICILSHPIKNTNDANSCQII-IPQNQVNRKS .... . ::.:. :: . :. : . : .. . .:.. .. .:. .: .. . . XP_016 ISEHFLVEDSYFPENMCSRV-QYRQISRAVLITDRSVLKTDSDQQISILTVPAEEPGTFA 280 290 300 310 320 330 340 350 360 370 380 pF1KB8 DIYVCMISYAHNVAAQGKYIAIASTTVETTDPEKEVEPALELLEPIDQK-FVAISDLYEP . : . . . .: :.. . : : : : :: . :: :: ... XP_016 -VRVIELCSSTMTCMKGTYLVHLTCTSSKT--------AREDLESVVQKLFVPYTEMEIE 340 350 360 370 380 390 400 410 420 430 440 pF1KB8 IDDGCESQVFCSCSYDATTHFETTCNDIKDIYKRMAGTAFDFENMKRKQNDVFGEAEQ XP_016 NEQVEKPRILWALYFNMRDSSDISRSCYNDLPSNVYVCSGPDCGLGNDNAVKQAETLFQE 390 400 410 420 430 440 >>XP_016884733 (OMIM: 300390,303100) PREDICTED: rab prot (505 aa) initn: 362 init1: 203 opt: 399 Z-score: 492.2 bits: 100.4 E(85289): 1.1e-20 Smith-Waterman score: 399; 26.0% identity (59.9% similar) in 327 aa overlap (69-386:76-386) 40 50 60 70 80 90 pF1KB8 YGGESSSITPLEELYKRFQLLEGPPESMGRGRDWNVDLIPKFLMANGQLVKMLLYTEVTR :: .:.::. :.:.. : :. .:. ..:.: XP_016 EDMSENVPIAEDTTEQPKKNRITYSQIIKEGRRFNIDLVSKLLYSRGLLIDLLIKSNVSR 50 60 70 80 90 100 100 110 120 130 140 150 pF1KB8 YLDFKVVEGSFVYKGGKIYKVPSTETEALASNLMGMFEKRRFRKFLVFVANFDENDPKTF : .:: . .... :.. .:: ...... :. . : ::: . :::.: .. :. : . XP_016 YAEFKNITRILAFREGRVEQVPCSRADVFNSKQLTMVEKRMLMKFLTFCMEY-EKYPDEY 110 120 130 140 150 160 160 170 180 190 200 210 pF1KB8 EGVDPQTTSMRDVYRKFDLGQDVIDFTGHALALYRTDDYLDQPCLETVNRIKLYSESLAR .: . : . . . : .. .. :..:. . . .. .. : . . :.: XP_016 KGYEEIT--FYEYLKTQKLTPNLQYIVMHSIAM---TSETASSTIDGLKATKNFLHCLGR 170 180 190 200 210 220 230 240 250 260 270 pF1KB8 YGKSPYLYPLYGLGELPQGFARLSAIYGGTYMLNKPVDDIIM--ENGKVVGVKSE-GEVA ::..:.:.:::: ::::: : :. :..:: : : . :. ... :. : .. .. :. XP_016 YGNTPFLFPLYGQGELPQCFCRMCAVFGGIYCLRHSVQCLVVDKESRKCKAIIDQFGQRI 220 230 240 250 260 270 280 290 300 310 320 330 pF1KB8 RCKQLICDPSYIPD----RVRKAGQVIRIICILSHPIKNTNDANSCQII-IPQNQVNRKS .... . ::.:. :: . :. : . : .. . .:.. .. .:. .: .. . . XP_016 ISEHFLVEDSYFPENMCSRV-QYRQISRAVLITDRSVLKTDSDQQISILTVPAEEPGTFA 280 290 300 310 320 330 340 350 360 370 380 pF1KB8 DIYVCMISYAHNVAAQGKYIAIASTTVETTDPEKEVEPALELLEPIDQK-FVAISDLYEP . : . . . .: :.. . : : : : :: . :: :: ... XP_016 -VRVIELCSSTMTCMKGTYLVHLTCTSSKT--------AREDLESVVQKLFVPYTEMEIE 340 350 360 370 380 390 400 410 420 430 440 pF1KB8 IDDGCESQVFCSCSYDATTHFETTCNDIKDIYKRMAGTAFDFENMKRKQNDVFGEAEQ XP_016 NEQVEKPRILWALYFNMRDSSDISRSCYNDLPSNVYVCSGPDCGLGNDNAVKQAETLFQE 390 400 410 420 430 440 447 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 09:28:18 2016 done: Fri Nov 4 09:28:19 2016 Total Scan time: 6.180 Total Display time: 0.040 Function used was FASTA [36.3.4 Apr, 2011]