FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8106, 177 aa 1>>>pF1KB8106 177 - 177 aa - 177 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.0434+/-0.000396; mu= 8.0019+/- 0.024 mean_var=56.6243+/-11.230, 0's: 0 Z-trim(110.8): 31 B-trim: 0 in 0/55 Lambda= 0.170440 statistics sampled from 19144 (19173) to 19144 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.599), E-opt: 0.2 (0.225), width: 16 Scan time: 3.950 The best scores are: opt bits E(85289) NP_057141 (OMIM: 615472) coatomer subunit zeta-1 i ( 177) 1113 281.9 3.6e-76 NP_001258665 (OMIM: 615472) coatomer subunit zeta- ( 185) 1081 274.1 8.8e-74 XP_016874486 (OMIM: 615472) PREDICTED: coatomer su ( 180) 937 238.7 3.9e-63 NP_001258663 (OMIM: 615472) coatomer subunit zeta- ( 154) 935 238.2 4.7e-63 NP_001258664 (OMIM: 615472) coatomer subunit zeta- ( 160) 920 234.5 6.2e-62 NP_057513 (OMIM: 615526) coatomer subunit zeta-2 [ ( 210) 859 219.5 2.7e-57 XP_011523176 (OMIM: 615526) PREDICTED: coatomer su ( 184) 508 133.2 2.3e-31 NP_005820 (OMIM: 602416) AP-3 complex subunit sigm ( 193) 166 49.1 4.9e-06 XP_016864513 (OMIM: 601507) PREDICTED: AP-3 comple ( 262) 165 48.8 8e-06 XP_011541438 (OMIM: 601507) PREDICTED: AP-3 comple ( 262) 165 48.8 8e-06 NP_001034658 (OMIM: 615781,616106) AP-1 complex su ( 154) 160 47.6 1.1e-05 NP_001305022 (OMIM: 601507) AP-3 complex subunit s ( 162) 159 47.4 1.4e-05 NP_001275 (OMIM: 601507) AP-3 complex subunit sigm ( 193) 154 46.1 3.8e-05 NP_001259000 (OMIM: 300629) AP-1 complex subunit s ( 160) 123 38.5 0.0062 XP_011543901 (OMIM: 300629) PREDICTED: AP-1 comple ( 202) 123 38.5 0.0078 XP_016885414 (OMIM: 300629) PREDICTED: AP-1 comple ( 202) 123 38.5 0.0078 NP_003907 (OMIM: 300629) AP-1 complex subunit sigm ( 157) 121 38.0 0.0085 >>NP_057141 (OMIM: 615472) coatomer subunit zeta-1 isofo (177 aa) initn: 1113 init1: 1113 opt: 1113 Z-score: 1488.5 bits: 281.9 E(85289): 3.6e-76 Smith-Waterman score: 1113; 100.0% identity (100.0% similar) in 177 aa overlap (1-177:1-177) 10 20 30 40 50 60 pF1KB8 MEALILEPSLYTVKAILILDNDGDRLFAKYYDDTYPSVKEQKAFEKNIFNKTHRTDSEIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 MEALILEPSLYTVKAILILDNDGDRLFAKYYDDTYPSVKEQKAFEKNIFNKTHRTDSEIA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 LLEGLTVVYKSSIDLYFYVIGSSYENELMLMAVLNCLFDSLSQMLRKNVEKRALLENMEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 LLEGLTVVYKSSIDLYFYVIGSSYENELMLMAVLNCLFDSLSQMLRKNVEKRALLENMEG 70 80 90 100 110 120 130 140 150 160 170 pF1KB8 LFLAVDEIVDGGVILESDPQQVVHRVALRGEDVPLTEQTVSQVLQSAKEQIKWSLLR ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 LFLAVDEIVDGGVILESDPQQVVHRVALRGEDVPLTEQTVSQVLQSAKEQIKWSLLR 130 140 150 160 170 >>NP_001258665 (OMIM: 615472) coatomer subunit zeta-1 is (185 aa) initn: 1080 init1: 1080 opt: 1081 Z-score: 1445.6 bits: 274.1 E(85289): 8.8e-74 Smith-Waterman score: 1081; 97.2% identity (98.3% similar) in 177 aa overlap (1-177:9-185) 10 20 30 40 50 pF1KB8 MEALILEPSLYTVKAILILDNDGDRLFAKYYDDTYPSVKEQKAFEKNIFNKT : . . :::::::::::::::::::::::::::::::::::::::::::::: NP_001 MGGFRTEGMFVSLQEPSLYTVKAILILDNDGDRLFAKYYDDTYPSVKEQKAFEKNIFNKT 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB8 HRTDSEIALLEGLTVVYKSSIDLYFYVIGSSYENELMLMAVLNCLFDSLSQMLRKNVEKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HRTDSEIALLEGLTVVYKSSIDLYFYVIGSSYENELMLMAVLNCLFDSLSQMLRKNVEKR 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB8 ALLENMEGLFLAVDEIVDGGVILESDPQQVVHRVALRGEDVPLTEQTVSQVLQSAKEQIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ALLENMEGLFLAVDEIVDGGVILESDPQQVVHRVALRGEDVPLTEQTVSQVLQSAKEQIK 130 140 150 160 170 180 pF1KB8 WSLLR ::::: NP_001 WSLLR >>XP_016874486 (OMIM: 615472) PREDICTED: coatomer subuni (180 aa) initn: 937 init1: 937 opt: 937 Z-score: 1254.5 bits: 238.7 E(85289): 3.9e-63 Smith-Waterman score: 937; 100.0% identity (100.0% similar) in 149 aa overlap (1-149:1-149) 10 20 30 40 50 60 pF1KB8 MEALILEPSLYTVKAILILDNDGDRLFAKYYDDTYPSVKEQKAFEKNIFNKTHRTDSEIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MEALILEPSLYTVKAILILDNDGDRLFAKYYDDTYPSVKEQKAFEKNIFNKTHRTDSEIA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 LLEGLTVVYKSSIDLYFYVIGSSYENELMLMAVLNCLFDSLSQMLRKNVEKRALLENMEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LLEGLTVVYKSSIDLYFYVIGSSYENELMLMAVLNCLFDSLSQMLRKNVEKRALLENMEG 70 80 90 100 110 120 130 140 150 160 170 pF1KB8 LFLAVDEIVDGGVILESDPQQVVHRVALRGEDVPLTEQTVSQVLQSAKEQIKWSLLR ::::::::::::::::::::::::::::: XP_016 LFLAVDEIVDGGVILESDPQQVVHRVALRVSKNVFLCIPASIHKHPPEPDLLDVSSSWGS 130 140 150 160 170 180 >>NP_001258663 (OMIM: 615472) coatomer subunit zeta-1 is (154 aa) initn: 954 init1: 935 opt: 935 Z-score: 1253.1 bits: 238.2 E(85289): 4.7e-63 Smith-Waterman score: 935; 100.0% identity (100.0% similar) in 148 aa overlap (30-177:7-154) 10 20 30 40 50 60 pF1KB8 MEALILEPSLYTVKAILILDNDGDRLFAKYYDDTYPSVKEQKAFEKNIFNKTHRTDSEIA ::::::::::::::::::::::::::::::: NP_001 MEALILYYDDTYPSVKEQKAFEKNIFNKTHRTDSEIA 10 20 30 70 80 90 100 110 120 pF1KB8 LLEGLTVVYKSSIDLYFYVIGSSYENELMLMAVLNCLFDSLSQMLRKNVEKRALLENMEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLEGLTVVYKSSIDLYFYVIGSSYENELMLMAVLNCLFDSLSQMLRKNVEKRALLENMEG 40 50 60 70 80 90 130 140 150 160 170 pF1KB8 LFLAVDEIVDGGVILESDPQQVVHRVALRGEDVPLTEQTVSQVLQSAKEQIKWSLLR ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LFLAVDEIVDGGVILESDPQQVVHRVALRGEDVPLTEQTVSQVLQSAKEQIKWSLLR 100 110 120 130 140 150 >>NP_001258664 (OMIM: 615472) coatomer subunit zeta-1 is (160 aa) initn: 920 init1: 920 opt: 920 Z-score: 1232.8 bits: 234.5 E(85289): 6.2e-62 Smith-Waterman score: 965; 90.4% identity (90.4% similar) in 177 aa overlap (1-177:1-160) 10 20 30 40 50 60 pF1KB8 MEALILEPSLYTVKAILILDNDGDRLFAKYYDDTYPSVKEQKAFEKNIFNKTHRTDSEIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MEALILEPSLYTVKAILILDNDGDRLFAKYYDDTYPSVKEQKAFEKNIFNKTHRTDSEIA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 LLEGLTVVYKSSIDLYFYVIGSSYENELMLMAVLNCLFDSLSQMLRKNVEKRALLENMEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLEGLTVVYKSSIDLYFYVIGSSYENELMLMAVLNCLFDSLSQMLRKNVEKRALLENMEG 70 80 90 100 110 120 130 140 150 160 170 pF1KB8 LFLAVDEIVDGGVILESDPQQVVHRVALRGEDVPLTEQTVSQVLQSAKEQIKWSLLR :::::::::::::::::::::::::: :::::::::::::: NP_001 LFLAVDEIVDGGVILESDPQQVVHRV-----------------LQSAKEQIKWSLLR 130 140 150 160 >>NP_057513 (OMIM: 615526) coatomer subunit zeta-2 [Homo (210 aa) initn: 873 init1: 859 opt: 859 Z-score: 1149.6 bits: 219.5 E(85289): 2.7e-57 Smith-Waterman score: 859; 74.9% identity (94.7% similar) in 171 aa overlap (7-177:40-210) 10 20 30 pF1KB8 MEALILEPSLYTVKAILILDNDGDRLFAKYYDDTYP ::::::.::..:::::: ::.:::::::.: NP_057 PHPGEGAAAAQAGGPAPPARAGEPSGLRLQEPSLYTIKAVFILDNDGRRLLAKYYDDTFP 10 20 30 40 50 60 40 50 60 70 80 90 pF1KB8 SVKEQKAFEKNIFNKTHRTDSEIALLEGLTVVYKSSIDLYFYVIGSSYENELMLMAVLNC :.::: .::::.:::: ::.::::.. :.:.:::.::::..::.:::::::::::.::.: NP_057 SMKEQMVFEKNVFNKTSRTESEIAFFGGMTIVYKNSIDLFLYVVGSSYENELMLMSVLTC 70 80 90 100 110 120 100 110 120 130 140 150 pF1KB8 LFDSLSQMLRKNVEKRALLENMEGLFLAVDEIVDGGVILESDPQQVVHRVALRGEDVPLT ::.::..::::::::: :::::.: ::..:::::::::::::::::...: .:..: :: NP_057 LFESLNHMLRKNVEKRWLLENMDGAFLVLDEIVDGGVILESDPQQVIQKVNFRADDGGLT 130 140 150 160 170 180 160 170 pF1KB8 EQTVSQVLQSAKEQIKWSLLR ::.:.:::::::::::::::. NP_057 EQSVAQVLQSAKEQIKWSLLK 190 200 210 >>XP_011523176 (OMIM: 615526) PREDICTED: coatomer subuni (184 aa) initn: 718 init1: 503 opt: 508 Z-score: 684.2 bits: 133.2 E(85289): 2.3e-31 Smith-Waterman score: 656; 62.0% identity (80.7% similar) in 171 aa overlap (7-177:40-184) 10 20 30 pF1KB8 MEALILEPSLYTVKAILILDNDGDRLFAKYYDDTYP ::::::.::..:::::: ::.:::::::.: XP_011 PHPGEGAAAAQAGGPAPPARAGEPSGLRLQEPSLYTIKAVFILDNDGRRLLAKYYDDTFP 10 20 30 40 50 60 40 50 60 70 80 90 pF1KB8 SVKEQKAFEKNIFNKTHRTDSEIALLEGLTVVYKSSIDLYFYVIGSSYENELMLMAVLNC :.::: .::::.:::: ::.::::.. :.:.:::.::::..::.:::::::::::.::.: XP_011 SMKEQMVFEKNVFNKTSRTESEIAFFGGMTIVYKNSIDLFLYVVGSSYENELMLMSVLTC 70 80 90 100 110 120 100 110 120 130 140 150 pF1KB8 LFDSLSQMLRKNVEKRALLENMEGLFLAVDEIVDGGVILESDPQQVVHRVALRGEDVPLT ::.::..:: .::::::::::...: .:..: :: XP_011 LFESLNHML--------------------------SVILESDPQQVIQKVNFRADDGGLT 130 140 150 160 160 170 pF1KB8 EQTVSQVLQSAKEQIKWSLLR ::.:.:::::::::::::::. XP_011 EQSVAQVLQSAKEQIKWSLLK 170 180 >>NP_005820 (OMIM: 602416) AP-3 complex subunit sigma-2 (193 aa) initn: 107 init1: 74 opt: 166 Z-score: 229.3 bits: 49.1 E(85289): 4.9e-06 Smith-Waterman score: 166; 23.2% identity (62.0% similar) in 142 aa overlap (13-146:2-141) 10 20 30 40 50 60 pF1KB8 MEALILEPSLYTVKAILILDNDGDRLFAKYYDDTYPSVKEQKAFEKNIFNKTHRTDSEIA ..:::...: : ....:. .: .:. .... .: :. NP_005 MIQAILVFNNHGKPRLVRFYQ-RFPEEIQQQIVRETFHLVLKRDDNICN 10 20 30 40 70 80 90 100 110 pF1KB8 LLEGLTVV--------YKSSIDLYFYVIGSSYENELMLMAVLNCLFDSLSQMLRKNVEKR .::: ... :. ::: .: :.:: .. ... . ..:.. . .:: . NP_005 FLEGGSLIGGSDYKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCF-ENVCEL 50 60 70 80 90 100 120 130 140 150 160 170 pF1KB8 ALLENMEGLFLAVDEIVDGGVILESDPQQVVHRVALRGEDVPLTEQTVSQVLQSAKEQIK :. .:. . ..:.: ::..::.. ...: .. NP_005 DLIFHMDKVHYILQEVVMGGMVLETNMNEIVAQIEAQNRLEKSEGGLSAAPARAVSAVKN 110 120 130 140 150 160 pF1KB8 WSLLR NP_005 INLPEIPRNINIGDLNIKVPNLSQFV 170 180 190 >>XP_016864513 (OMIM: 601507) PREDICTED: AP-3 complex su (262 aa) initn: 151 init1: 71 opt: 165 Z-score: 225.6 bits: 48.8 E(85289): 8e-06 Smith-Waterman score: 165; 22.9% identity (60.6% similar) in 170 aa overlap (8-169:97-260) 10 20 30 pF1KB8 MEALILEPSLYTVKAILILDNDGDRLFAKYYDDTYPS :. .:::::..: : ..:.:. : XP_016 GGGWGRIAGEITRRGSRARPRPGPQCPPGRPGTAMIKAILIFNNHGKPRLSKFYQP-YSE 70 80 90 100 110 120 40 50 60 70 80 pF1KB8 VKEQKAFEKNIFNKTHRTDSEIALLEG-LTV-------VYKSSIDLYFYVIGSSYENELM .:. ..... ..: .. .::: : . .:. ::: .: :.:: XP_016 DTQQQIIRETFHLVSKRDENVCNFLEGGLLIGGSDNKLIYRHYATLYFVFCVDSSESELG 130 140 150 160 170 180 90 100 110 120 130 140 pF1KB8 LMAVLNCLFDSLSQMLRKNVEKRALLENMEGLFLAVDEIVDGGVILESDPQQVVHRVALR .. ... . ..:.. . .:: . :. ... . . :.: ::..::.. ...: .. . XP_016 ILDLIQVFVETLDKCF-ENVCELDLIFHVDKVHNILAEMVMGGMVLETNMNEIVTQIDAQ 190 200 210 220 230 240 150 160 170 pF1KB8 GEDVPLTEQTVSQVLQSAKEQIKWSLLR .. :.. . ..:: .. XP_016 NK----LEKSETFIFQSPRQDR 250 260 >>XP_011541438 (OMIM: 601507) PREDICTED: AP-3 complex su (262 aa) initn: 151 init1: 71 opt: 165 Z-score: 225.6 bits: 48.8 E(85289): 8e-06 Smith-Waterman score: 165; 22.9% identity (60.6% similar) in 170 aa overlap (8-169:97-260) 10 20 30 pF1KB8 MEALILEPSLYTVKAILILDNDGDRLFAKYYDDTYPS :. .:::::..: : ..:.:. : XP_011 GGGWGRIAGEITRRGSRARPRPGPQCPPGRPGTAMIKAILIFNNHGKPRLSKFYQP-YSE 70 80 90 100 110 120 40 50 60 70 80 pF1KB8 VKEQKAFEKNIFNKTHRTDSEIALLEG-LTV-------VYKSSIDLYFYVIGSSYENELM .:. ..... ..: .. .::: : . .:. ::: .: :.:: XP_011 DTQQQIIRETFHLVSKRDENVCNFLEGGLLIGGSDNKLIYRHYATLYFVFCVDSSESELG 130 140 150 160 170 180 90 100 110 120 130 140 pF1KB8 LMAVLNCLFDSLSQMLRKNVEKRALLENMEGLFLAVDEIVDGGVILESDPQQVVHRVALR .. ... . ..:.. . .:: . :. ... . . :.: ::..::.. ...: .. . XP_011 ILDLIQVFVETLDKCF-ENVCELDLIFHVDKVHNILAEMVMGGMVLETNMNEIVTQIDAQ 190 200 210 220 230 240 150 160 170 pF1KB8 GEDVPLTEQTVSQVLQSAKEQIKWSLLR .. :.. . ..:: .. XP_011 NK----LEKSETFIFQSPRQDR 250 260 177 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 09:32:35 2016 done: Fri Nov 4 09:32:35 2016 Total Scan time: 3.950 Total Display time: -0.020 Function used was FASTA [36.3.4 Apr, 2011]