FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8110, 180 aa 1>>>pF1KB8110 180 - 180 aa - 180 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.2865+/-0.000268; mu= 6.3226+/- 0.017 mean_var=165.9977+/-34.257, 0's: 0 Z-trim(125.0): 19 B-trim: 756 in 1/55 Lambda= 0.099546 statistics sampled from 47742 (47762) to 47742 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.856), E-opt: 0.2 (0.56), width: 16 Scan time: 5.570 The best scores are: opt bits E(85289) NP_001191013 (OMIM: 600613) neuroblastoma suppress ( 181) 1312 198.7 4.2e-51 NP_001265093 (OMIM: 600613) neuroblastoma suppress ( 181) 1312 198.7 4.2e-51 NP_001191014 (OMIM: 600613) neuroblastoma suppress ( 181) 1312 198.7 4.2e-51 NP_001265094 (OMIM: 600613) neuroblastoma suppress ( 181) 1312 198.7 4.2e-51 NP_005371 (OMIM: 600613) neuroblastoma suppressor ( 181) 1312 198.7 4.2e-51 NP_001265095 (OMIM: 600613) neuroblastoma suppress ( 181) 1312 198.7 4.2e-51 NP_001191015 (OMIM: 600613) neuroblastoma suppress ( 215) 1312 198.8 4.7e-51 NP_877421 (OMIM: 600613) neuroblastoma suppressor ( 216) 1312 198.8 4.7e-51 XP_011542551 (OMIM: 608832) PREDICTED: gremlin-2 i ( 168) 249 46.0 3.6e-05 NP_071914 (OMIM: 608832) gremlin-2 precursor [Homo ( 168) 249 46.0 3.6e-05 XP_005273283 (OMIM: 608832) PREDICTED: gremlin-2 i ( 186) 249 46.1 3.8e-05 NP_001178252 (OMIM: 603054) gremlin-1 isoform 2 pr ( 143) 231 43.4 0.00019 NP_001178251 (OMIM: 603054) gremlin-1 isoform 3 [H ( 114) 219 41.6 0.00053 NP_037504 (OMIM: 603054) gremlin-1 isoform 1 precu ( 184) 219 41.8 0.00075 XP_016877566 (OMIM: 603054) PREDICTED: gremlin-1 i ( 221) 219 41.8 0.00086 XP_005254358 (OMIM: 603054) PREDICTED: gremlin-1 i ( 240) 219 41.9 0.00091 >>NP_001191013 (OMIM: 600613) neuroblastoma suppressor o (181 aa) initn: 1312 init1: 1312 opt: 1312 Z-score: 1038.5 bits: 198.7 E(85289): 4.2e-51 Smith-Waterman score: 1312; 100.0% identity (100.0% similar) in 180 aa overlap (1-180:2-181) 10 20 30 40 50 pF1KB8 MLRVLVGAVLPAMLLAAPPPINKLALFPDKSAWCEAKNITQIVGHSGCEAKSIQNRACL ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MMLRVLVGAVLPAMLLAAPPPINKLALFPDKSAWCEAKNITQIVGHSGCEAKSIQNRACL 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB8 GQCFSYSVPNTFPQSTESLVHCDSCMPAQSMWEIVTLECPGHEEVPRVDKLVEKILHCSC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GQCFSYSVPNTFPQSTESLVHCDSCMPAQSMWEIVTLECPGHEEVPRVDKLVEKILHCSC 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB8 QACGKEPSHEGLSVYVQGEDGPGSQPGTHPHPHPHPHPGGQTPEPEDPPGAPHTEEEGAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QACGKEPSHEGLSVYVQGEDGPGSQPGTHPHPHPHPHPGGQTPEPEDPPGAPHTEEEGAE 130 140 150 160 170 180 180 pF1KB8 D : NP_001 D >>NP_001265093 (OMIM: 600613) neuroblastoma suppressor o (181 aa) initn: 1312 init1: 1312 opt: 1312 Z-score: 1038.5 bits: 198.7 E(85289): 4.2e-51 Smith-Waterman score: 1312; 100.0% identity (100.0% similar) in 180 aa overlap (1-180:2-181) 10 20 30 40 50 pF1KB8 MLRVLVGAVLPAMLLAAPPPINKLALFPDKSAWCEAKNITQIVGHSGCEAKSIQNRACL ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MMLRVLVGAVLPAMLLAAPPPINKLALFPDKSAWCEAKNITQIVGHSGCEAKSIQNRACL 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB8 GQCFSYSVPNTFPQSTESLVHCDSCMPAQSMWEIVTLECPGHEEVPRVDKLVEKILHCSC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GQCFSYSVPNTFPQSTESLVHCDSCMPAQSMWEIVTLECPGHEEVPRVDKLVEKILHCSC 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB8 QACGKEPSHEGLSVYVQGEDGPGSQPGTHPHPHPHPHPGGQTPEPEDPPGAPHTEEEGAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QACGKEPSHEGLSVYVQGEDGPGSQPGTHPHPHPHPHPGGQTPEPEDPPGAPHTEEEGAE 130 140 150 160 170 180 180 pF1KB8 D : NP_001 D >>NP_001191014 (OMIM: 600613) neuroblastoma suppressor o (181 aa) initn: 1312 init1: 1312 opt: 1312 Z-score: 1038.5 bits: 198.7 E(85289): 4.2e-51 Smith-Waterman score: 1312; 100.0% identity (100.0% similar) in 180 aa overlap (1-180:2-181) 10 20 30 40 50 pF1KB8 MLRVLVGAVLPAMLLAAPPPINKLALFPDKSAWCEAKNITQIVGHSGCEAKSIQNRACL ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MMLRVLVGAVLPAMLLAAPPPINKLALFPDKSAWCEAKNITQIVGHSGCEAKSIQNRACL 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB8 GQCFSYSVPNTFPQSTESLVHCDSCMPAQSMWEIVTLECPGHEEVPRVDKLVEKILHCSC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GQCFSYSVPNTFPQSTESLVHCDSCMPAQSMWEIVTLECPGHEEVPRVDKLVEKILHCSC 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB8 QACGKEPSHEGLSVYVQGEDGPGSQPGTHPHPHPHPHPGGQTPEPEDPPGAPHTEEEGAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QACGKEPSHEGLSVYVQGEDGPGSQPGTHPHPHPHPHPGGQTPEPEDPPGAPHTEEEGAE 130 140 150 160 170 180 180 pF1KB8 D : NP_001 D >>NP_001265094 (OMIM: 600613) neuroblastoma suppressor o (181 aa) initn: 1312 init1: 1312 opt: 1312 Z-score: 1038.5 bits: 198.7 E(85289): 4.2e-51 Smith-Waterman score: 1312; 100.0% identity (100.0% similar) in 180 aa overlap (1-180:2-181) 10 20 30 40 50 pF1KB8 MLRVLVGAVLPAMLLAAPPPINKLALFPDKSAWCEAKNITQIVGHSGCEAKSIQNRACL ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MMLRVLVGAVLPAMLLAAPPPINKLALFPDKSAWCEAKNITQIVGHSGCEAKSIQNRACL 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB8 GQCFSYSVPNTFPQSTESLVHCDSCMPAQSMWEIVTLECPGHEEVPRVDKLVEKILHCSC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GQCFSYSVPNTFPQSTESLVHCDSCMPAQSMWEIVTLECPGHEEVPRVDKLVEKILHCSC 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB8 QACGKEPSHEGLSVYVQGEDGPGSQPGTHPHPHPHPHPGGQTPEPEDPPGAPHTEEEGAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QACGKEPSHEGLSVYVQGEDGPGSQPGTHPHPHPHPHPGGQTPEPEDPPGAPHTEEEGAE 130 140 150 160 170 180 180 pF1KB8 D : NP_001 D >>NP_005371 (OMIM: 600613) neuroblastoma suppressor of t (181 aa) initn: 1312 init1: 1312 opt: 1312 Z-score: 1038.5 bits: 198.7 E(85289): 4.2e-51 Smith-Waterman score: 1312; 100.0% identity (100.0% similar) in 180 aa overlap (1-180:2-181) 10 20 30 40 50 pF1KB8 MLRVLVGAVLPAMLLAAPPPINKLALFPDKSAWCEAKNITQIVGHSGCEAKSIQNRACL ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MMLRVLVGAVLPAMLLAAPPPINKLALFPDKSAWCEAKNITQIVGHSGCEAKSIQNRACL 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB8 GQCFSYSVPNTFPQSTESLVHCDSCMPAQSMWEIVTLECPGHEEVPRVDKLVEKILHCSC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 GQCFSYSVPNTFPQSTESLVHCDSCMPAQSMWEIVTLECPGHEEVPRVDKLVEKILHCSC 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB8 QACGKEPSHEGLSVYVQGEDGPGSQPGTHPHPHPHPHPGGQTPEPEDPPGAPHTEEEGAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 QACGKEPSHEGLSVYVQGEDGPGSQPGTHPHPHPHPHPGGQTPEPEDPPGAPHTEEEGAE 130 140 150 160 170 180 180 pF1KB8 D : NP_005 D >>NP_001265095 (OMIM: 600613) neuroblastoma suppressor o (181 aa) initn: 1312 init1: 1312 opt: 1312 Z-score: 1038.5 bits: 198.7 E(85289): 4.2e-51 Smith-Waterman score: 1312; 100.0% identity (100.0% similar) in 180 aa overlap (1-180:2-181) 10 20 30 40 50 pF1KB8 MLRVLVGAVLPAMLLAAPPPINKLALFPDKSAWCEAKNITQIVGHSGCEAKSIQNRACL ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MMLRVLVGAVLPAMLLAAPPPINKLALFPDKSAWCEAKNITQIVGHSGCEAKSIQNRACL 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB8 GQCFSYSVPNTFPQSTESLVHCDSCMPAQSMWEIVTLECPGHEEVPRVDKLVEKILHCSC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GQCFSYSVPNTFPQSTESLVHCDSCMPAQSMWEIVTLECPGHEEVPRVDKLVEKILHCSC 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB8 QACGKEPSHEGLSVYVQGEDGPGSQPGTHPHPHPHPHPGGQTPEPEDPPGAPHTEEEGAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QACGKEPSHEGLSVYVQGEDGPGSQPGTHPHPHPHPHPGGQTPEPEDPPGAPHTEEEGAE 130 140 150 160 170 180 180 pF1KB8 D : NP_001 D >>NP_001191015 (OMIM: 600613) neuroblastoma suppressor o (215 aa) initn: 1312 init1: 1312 opt: 1312 Z-score: 1037.6 bits: 198.8 E(85289): 4.7e-51 Smith-Waterman score: 1312; 100.0% identity (100.0% similar) in 180 aa overlap (1-180:36-215) 10 20 30 pF1KB8 MLRVLVGAVLPAMLLAAPPPINKLALFPDK :::::::::::::::::::::::::::::: NP_001 LQQLISMDLFWRLFFVCGQEGLRALEATGMMLRVLVGAVLPAMLLAAPPPINKLALFPDK 10 20 30 40 50 60 40 50 60 70 80 90 pF1KB8 SAWCEAKNITQIVGHSGCEAKSIQNRACLGQCFSYSVPNTFPQSTESLVHCDSCMPAQSM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SAWCEAKNITQIVGHSGCEAKSIQNRACLGQCFSYSVPNTFPQSTESLVHCDSCMPAQSM 70 80 90 100 110 120 100 110 120 130 140 150 pF1KB8 WEIVTLECPGHEEVPRVDKLVEKILHCSCQACGKEPSHEGLSVYVQGEDGPGSQPGTHPH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 WEIVTLECPGHEEVPRVDKLVEKILHCSCQACGKEPSHEGLSVYVQGEDGPGSQPGTHPH 130 140 150 160 170 180 160 170 180 pF1KB8 PHPHPHPGGQTPEPEDPPGAPHTEEEGAED :::::::::::::::::::::::::::::: NP_001 PHPHPHPGGQTPEPEDPPGAPHTEEEGAED 190 200 210 >>NP_877421 (OMIM: 600613) neuroblastoma suppressor of t (216 aa) initn: 1312 init1: 1312 opt: 1312 Z-score: 1037.5 bits: 198.8 E(85289): 4.7e-51 Smith-Waterman score: 1312; 100.0% identity (100.0% similar) in 180 aa overlap (1-180:37-216) 10 20 30 pF1KB8 MLRVLVGAVLPAMLLAAPPPINKLALFPDK :::::::::::::::::::::::::::::: NP_877 SQTSRAVSIWKFPAKLGKTHGHRALEATGMMLRVLVGAVLPAMLLAAPPPINKLALFPDK 10 20 30 40 50 60 40 50 60 70 80 90 pF1KB8 SAWCEAKNITQIVGHSGCEAKSIQNRACLGQCFSYSVPNTFPQSTESLVHCDSCMPAQSM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_877 SAWCEAKNITQIVGHSGCEAKSIQNRACLGQCFSYSVPNTFPQSTESLVHCDSCMPAQSM 70 80 90 100 110 120 100 110 120 130 140 150 pF1KB8 WEIVTLECPGHEEVPRVDKLVEKILHCSCQACGKEPSHEGLSVYVQGEDGPGSQPGTHPH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_877 WEIVTLECPGHEEVPRVDKLVEKILHCSCQACGKEPSHEGLSVYVQGEDGPGSQPGTHPH 130 140 150 160 170 180 160 170 180 pF1KB8 PHPHPHPGGQTPEPEDPPGAPHTEEEGAED :::::::::::::::::::::::::::::: NP_877 PHPHPHPGGQTPEPEDPPGAPHTEEEGAED 190 200 210 >>XP_011542551 (OMIM: 608832) PREDICTED: gremlin-2 isofo (168 aa) initn: 231 init1: 217 opt: 249 Z-score: 213.9 bits: 46.0 E(85289): 3.6e-05 Smith-Waterman score: 249; 35.9% identity (62.0% similar) in 92 aa overlap (30-121:69-159) 10 20 30 40 50 pF1KB8 MLRVLVGAVLPAMLLAAPPPINKLALFPDKSAWCEAKNITQIVGHSGCEAKSIQNRACL :: ::... . : :.. ::....: :: : XP_011 SNNSERWQHQIKEVLASSQEALVVTERKYLKSDWCKTQPLRQTVSEEGCRSRTILNRFCY 40 50 60 70 80 90 60 70 80 90 100 110 pF1KB8 GQCFSYSVPNTFPQSTESLVHCDSCMPAQSMWEIVTLECPGHEEVPRVDKLVEKILHCSC ::: :. .: . ::. : : : . .: ::::: . :. : ..:. .: : XP_011 GQCNSFYIPRHVKKEEESFQSCAFCKPQRVTSVLVELECPGLDPPFRLKK-IQKVKQCRC 100 110 120 130 140 150 120 130 140 150 160 170 pF1KB8 QACGKEPSHEGLSVYVQGEDGPGSQPGTHPHPHPHPHPGGQTPEPEDPPGAPHTEEEGAE .. XP_011 MSVNLSDSDKQ 160 >>NP_071914 (OMIM: 608832) gremlin-2 precursor [Homo sap (168 aa) initn: 231 init1: 217 opt: 249 Z-score: 213.9 bits: 46.0 E(85289): 3.6e-05 Smith-Waterman score: 249; 35.9% identity (62.0% similar) in 92 aa overlap (30-121:69-159) 10 20 30 40 50 pF1KB8 MLRVLVGAVLPAMLLAAPPPINKLALFPDKSAWCEAKNITQIVGHSGCEAKSIQNRACL :: ::... . : :.. ::....: :: : NP_071 SNNSERWQHQIKEVLASSQEALVVTERKYLKSDWCKTQPLRQTVSEEGCRSRTILNRFCY 40 50 60 70 80 90 60 70 80 90 100 110 pF1KB8 GQCFSYSVPNTFPQSTESLVHCDSCMPAQSMWEIVTLECPGHEEVPRVDKLVEKILHCSC ::: :. .: . ::. : : : . .: ::::: . :. : ..:. .: : NP_071 GQCNSFYIPRHVKKEEESFQSCAFCKPQRVTSVLVELECPGLDPPFRLKK-IQKVKQCRC 100 110 120 130 140 150 120 130 140 150 160 170 pF1KB8 QACGKEPSHEGLSVYVQGEDGPGSQPGTHPHPHPHPHPGGQTPEPEDPPGAPHTEEEGAE .. NP_071 MSVNLSDSDKQ 160 180 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 09:36:01 2016 done: Fri Nov 4 09:36:02 2016 Total Scan time: 5.570 Total Display time: -0.020 Function used was FASTA [36.3.4 Apr, 2011]