FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8112, 152 aa 1>>>pF1KB8112 152 - 152 aa - 152 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.2393+/-0.000308; mu= 12.0381+/- 0.019 mean_var=66.4452+/-13.214, 0's: 0 Z-trim(117.2): 127 B-trim: 74 in 1/55 Lambda= 0.157341 statistics sampled from 28930 (29074) to 28930 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.736), E-opt: 0.2 (0.341), width: 16 Scan time: 4.110 The best scores are: opt bits E(85289) NP_003339 (OMIM: 603679) ubiquitin-conjugating enz ( 152) 1019 239.5 1.6e-63 NP_054895 (OMIM: 610538,616435) ubiquitin-conjugat ( 197) 464 113.6 1.7e-25 NP_003330 (OMIM: 602962) ubiquitin-conjugating enz ( 147) 460 112.6 2.4e-25 NP_871621 (OMIM: 602963) ubiquitin-conjugating enz ( 148) 459 112.4 2.9e-25 NP_871617 (OMIM: 602963) ubiquitin-conjugating enz ( 147) 456 111.7 4.6e-25 NP_871616 (OMIM: 602963) ubiquitin-conjugating enz ( 147) 456 111.7 4.6e-25 NP_871618 (OMIM: 602963) ubiquitin-conjugating enz ( 147) 456 111.7 4.6e-25 NP_871615 (OMIM: 602963) ubiquitin-conjugating enz ( 147) 456 111.7 4.6e-25 NP_871620 (OMIM: 602963) ubiquitin-conjugating enz ( 147) 456 111.7 4.6e-25 NP_003331 (OMIM: 602963) ubiquitin-conjugating enz ( 147) 456 111.7 4.6e-25 NP_871619 (OMIM: 602963) ubiquitin-conjugating enz ( 147) 456 111.7 4.6e-25 NP_003329 (OMIM: 602961) ubiquitin-conjugating enz ( 147) 453 111.0 7.4e-25 NP_871622 (OMIM: 602963) ubiquitin-conjugating enz ( 149) 444 109.0 3.1e-24 NP_005330 (OMIM: 602846) ubiquitin-conjugating enz ( 200) 444 109.0 3.9e-24 XP_016865309 (OMIM: 602962) PREDICTED: ubiquitin-c ( 173) 443 108.8 4.1e-24 NP_862821 (OMIM: 602962) ubiquitin-conjugating enz ( 118) 432 106.2 1.7e-23 NP_001287724 (OMIM: 602963) ubiquitin-conjugating ( 118) 427 105.0 3.7e-23 XP_016864073 (OMIM: 602963) PREDICTED: ubiquitin-c ( 118) 427 105.0 3.7e-23 NP_003332 (OMIM: 602916) ubiquitin-conjugating enz ( 193) 429 105.6 4e-23 NP_001189405 (OMIM: 602916) ubiquitin-conjugating ( 160) 426 104.9 5.5e-23 NP_689866 (OMIM: 602163) ubiquitin-conjugating enz ( 201) 427 105.2 5.7e-23 XP_005265489 (OMIM: 602163) PREDICTED: ubiquitin-c ( 201) 427 105.2 5.7e-23 NP_003327 (OMIM: 300860,312180) ubiquitin-conjugat ( 152) 425 104.6 6.2e-23 NP_001265484 (OMIM: 604151) ubiquitin-conjugating ( 207) 426 105.0 6.8e-23 NP_001265483 (OMIM: 604151) ubiquitin-conjugating ( 207) 426 105.0 6.8e-23 NP_006348 (OMIM: 604151) ubiquitin-conjugating enz ( 207) 426 105.0 6.8e-23 NP_872619 (OMIM: 604151) ubiquitin-conjugating enz ( 207) 426 105.0 6.8e-23 XP_005246301 (OMIM: 604151) PREDICTED: ubiquitin-c ( 207) 426 105.0 6.8e-23 NP_003328 (OMIM: 179095) ubiquitin-conjugating enz ( 152) 423 104.2 8.5e-23 XP_016872098 (OMIM: 602961) PREDICTED: ubiquitin-c ( 110) 417 102.7 1.7e-22 NP_001297255 (OMIM: 610538,616435) ubiquitin-conju ( 167) 419 103.3 1.7e-22 NP_001191809 (OMIM: 602961) ubiquitin-conjugating ( 109) 400 98.9 2.4e-21 NP_001104582 (OMIM: 602846) ubiquitin-conjugating ( 157) 397 98.3 5.2e-21 NP_872607 (OMIM: 602916) ubiquitin-conjugating enz ( 176) 393 97.4 1.1e-20 NP_055316 (OMIM: 610309) ubiquitin-conjugating enz ( 222) 372 92.7 3.5e-19 NP_008950 (OMIM: 605574) ubiquitin-conjugating enz ( 179) 366 91.3 7.6e-19 NP_001269090 (OMIM: 300860,312180) ubiquitin-conju ( 119) 354 88.5 3.6e-18 NP_861517 (OMIM: 605574) ubiquitin-conjugating enz ( 140) 352 88.1 5.6e-18 XP_005265490 (OMIM: 602163) PREDICTED: ubiquitin-c ( 189) 342 85.9 3.5e-17 XP_005265488 (OMIM: 602916) PREDICTED: ubiquitin-c ( 167) 334 84.0 1.1e-16 NP_003338 (OMIM: 603721) ubiquitin-conjugating enz ( 154) 333 83.8 1.2e-16 NP_861516 (OMIM: 605574) ubiquitin-conjugating enz ( 150) 326 82.2 3.6e-16 NP_001243284 (OMIM: 603721) ubiquitin-conjugating ( 212) 320 80.9 1.2e-15 XP_011525054 (OMIM: 610309) PREDICTED: ubiquitin-c ( 162) 315 79.7 2.1e-15 NP_001104583 (OMIM: 602846) ubiquitin-conjugating ( 149) 307 77.9 7.1e-15 NP_001243285 (OMIM: 603721) ubiquitin-conjugating ( 122) 303 76.9 1.1e-14 NP_004214 (OMIM: 603890) ubiquitin/ISG15-conjugati ( 153) 297 75.6 3.5e-14 NP_919236 (OMIM: 601661) SUMO-conjugating enzyme U ( 158) 295 75.1 4.9e-14 XP_016879129 (OMIM: 601661) PREDICTED: SUMO-conjug ( 158) 295 75.1 4.9e-14 NP_003336 (OMIM: 601661) SUMO-conjugating enzyme U ( 158) 295 75.1 4.9e-14 >>NP_003339 (OMIM: 603679) ubiquitin-conjugating enzyme (152 aa) initn: 1019 init1: 1019 opt: 1019 Z-score: 1261.4 bits: 239.5 E(85289): 1.6e-63 Smith-Waterman score: 1019; 100.0% identity (100.0% similar) in 152 aa overlap (1-152:1-152) 10 20 30 40 50 60 pF1KB8 MAGLPRRIIKETQRLLAEPVPGIKAEPDESNARYFHVVIAGPQDSPFEGGTFKLELFLPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 MAGLPRRIIKETQRLLAEPVPGIKAEPDESNARYFHVVIAGPQDSPFEGGTFKLELFLPE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 EYPMAAPKVRFMTKIYHPNVDKLGRICLDILKDKWSPALQIRTVLLSIQALLSAPNPDDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 EYPMAAPKVRFMTKIYHPNVDKLGRICLDILKDKWSPALQIRTVLLSIQALLSAPNPDDP 70 80 90 100 110 120 130 140 150 pF1KB8 LANDVAEQWKTNEAQAIETARAWTRLYAMNNI :::::::::::::::::::::::::::::::: NP_003 LANDVAEQWKTNEAQAIETARAWTRLYAMNNI 130 140 150 >>NP_054895 (OMIM: 610538,616435) ubiquitin-conjugating (197 aa) initn: 437 init1: 294 opt: 464 Z-score: 578.9 bits: 113.6 E(85289): 1.7e-25 Smith-Waterman score: 464; 45.9% identity (71.9% similar) in 146 aa overlap (7-148:6-151) 10 20 30 40 50 60 pF1KB8 MAGLPRRIIKETQRLLAEPVPGIKAEPDESNARYFHVVIAGPQDSPFEGGTFKLELFLPE :. .: . : .:: ::: :... ... : : ..:.: :.::::...:: NP_054 MQRASRLKRELHMLATEPPPGITCWQDKDQMDDLRAQILGGANTPYEKGVFKLEVIIPE 10 20 30 40 50 70 80 90 100 110 pF1KB8 EYPMAAPKVRFMTKIYHPNVDKLGRICLDILK----DKWSPALQIRTVLLSIQALLSAPN .::. :..::.: :::::.:. ::::::.:: : :.:.: ::: ::: :.: :: NP_054 RYPFEPPQIRFLTPIYHPNIDSAGRICLDVLKLPPKGAWRPSLNIATVLTSIQLLMSEPN 60 70 80 90 100 110 120 130 140 150 pF1KB8 PDDPLANDVAEQWKTNEAQAIETARAWTRLYAMNNI ::::: :.. ..: :. ...:: ::. .: NP_054 PDDPLMADISSEFKYNKPAFLKNARQWTEKHARQKQKADEEEMLDNLPEAGDSRVHNSTQ 120 130 140 150 160 170 NP_054 KRKASQLVGIEKKFHPDV 180 190 >>NP_003330 (OMIM: 602962) ubiquitin-conjugating enzyme (147 aa) initn: 460 init1: 460 opt: 460 Z-score: 575.9 bits: 112.6 E(85289): 2.4e-25 Smith-Waterman score: 460; 47.2% identity (72.9% similar) in 144 aa overlap (6-149:4-147) 10 20 30 40 50 60 pF1KB8 MAGLPRRIIKETQRLLAEPVPGIKAEPDESNARYFHVVIAGPQDSPFEGGTFKLELFLPE .:: :: . : .: .: : .. .....: ::.:::..::.: : . .: NP_003 MALKRIHKELNDLARDPPAQCSAGPVGDDMFHWQATIMGPNDSPYQGGVFFLTIHFPT 10 20 30 40 50 70 80 90 100 110 120 pF1KB8 EYPMAAPKVRFMTKIYHPNVDKLGRICLDILKDKWSPALQIRTVLLSIQALLSAPNPDDP .::. ::: : :.:::::... : ::::::...::::: : ::::: .:: :::::: NP_003 DYPFKPPKVAFTTRIYHPNINSNGSICLDILRSQWSPALTISKVLLSICSLLCDPNPDDP 60 70 80 90 100 110 130 140 150 pF1KB8 LANDVAEQWKTNEAQAIETARAWTRLYAMNNI :. ..:. .::.. . . :: ::. ::: NP_003 LVPEIARIYKTDREKYNRIAREWTQKYAM 120 130 140 >>NP_871621 (OMIM: 602963) ubiquitin-conjugating enzyme (148 aa) initn: 459 init1: 459 opt: 459 Z-score: 574.6 bits: 112.4 E(85289): 2.9e-25 Smith-Waterman score: 459; 47.2% identity (72.9% similar) in 144 aa overlap (6-149:4-147) 10 20 30 40 50 60 pF1KB8 MAGLPRRIIKETQRLLAEPVPGIKAEPDESNARYFHVVIAGPQDSPFEGGTFKLELFLPE .:: :: . : .: .: : .. .....: ::.:::..::.: : . .: NP_871 MALKRINKELSDLARDPPAQCSAGPVGDDMFHWQATIMGPNDSPYQGGVFFLTIHFPT 10 20 30 40 50 70 80 90 100 110 120 pF1KB8 EYPMAAPKVRFMTKIYHPNVDKLGRICLDILKDKWSPALQIRTVLLSIQALLSAPNPDDP .::. ::: : :.:::::... : ::::::...::::: : ::::: .:: :::::: NP_871 DYPFKPPKVAFTTRIYHPNINSNGSICLDILRSQWSPALTISKVLLSICSLLCDPNPDDP 60 70 80 90 100 110 130 140 150 pF1KB8 LANDVAEQWKTNEAQAIETARAWTRLYAMNNI :. ..:. .::.. . . :: ::. ::: NP_871 LVPEIARIYKTDRDKYNRLAREWTEKYAML 120 130 140 >>NP_871617 (OMIM: 602963) ubiquitin-conjugating enzyme (147 aa) initn: 456 init1: 456 opt: 456 Z-score: 571.0 bits: 111.7 E(85289): 4.6e-25 Smith-Waterman score: 456; 46.5% identity (72.9% similar) in 144 aa overlap (6-149:4-147) 10 20 30 40 50 60 pF1KB8 MAGLPRRIIKETQRLLAEPVPGIKAEPDESNARYFHVVIAGPQDSPFEGGTFKLELFLPE .:: :: . : .: .: : .. .....: ::.:::..::.: : . .: NP_871 MALKRINKELSDLARDPPAQCSAGPVGDDMFHWQATIMGPNDSPYQGGVFFLTIHFPT 10 20 30 40 50 70 80 90 100 110 120 pF1KB8 EYPMAAPKVRFMTKIYHPNVDKLGRICLDILKDKWSPALQIRTVLLSIQALLSAPNPDDP .::. ::: : :.:::::... : ::::::...::::: : ::::: .:: :::::: NP_871 DYPFKPPKVAFTTRIYHPNINSNGSICLDILRSQWSPALTISKVLLSICSLLCDPNPDDP 60 70 80 90 100 110 130 140 150 pF1KB8 LANDVAEQWKTNEAQAIETARAWTRLYAMNNI :. ..:. .::.. . . .: ::. ::: NP_871 LVPEIARIYKTDRDKYNRISREWTQKYAM 120 130 140 >>NP_871616 (OMIM: 602963) ubiquitin-conjugating enzyme (147 aa) initn: 456 init1: 456 opt: 456 Z-score: 571.0 bits: 111.7 E(85289): 4.6e-25 Smith-Waterman score: 456; 46.5% identity (72.9% similar) in 144 aa overlap (6-149:4-147) 10 20 30 40 50 60 pF1KB8 MAGLPRRIIKETQRLLAEPVPGIKAEPDESNARYFHVVIAGPQDSPFEGGTFKLELFLPE .:: :: . : .: .: : .. .....: ::.:::..::.: : . .: NP_871 MALKRINKELSDLARDPPAQCSAGPVGDDMFHWQATIMGPNDSPYQGGVFFLTIHFPT 10 20 30 40 50 70 80 90 100 110 120 pF1KB8 EYPMAAPKVRFMTKIYHPNVDKLGRICLDILKDKWSPALQIRTVLLSIQALLSAPNPDDP .::. ::: : :.:::::... : ::::::...::::: : ::::: .:: :::::: NP_871 DYPFKPPKVAFTTRIYHPNINSNGSICLDILRSQWSPALTISKVLLSICSLLCDPNPDDP 60 70 80 90 100 110 130 140 150 pF1KB8 LANDVAEQWKTNEAQAIETARAWTRLYAMNNI :. ..:. .::.. . . .: ::. ::: NP_871 LVPEIARIYKTDRDKYNRISREWTQKYAM 120 130 140 >>NP_871618 (OMIM: 602963) ubiquitin-conjugating enzyme (147 aa) initn: 456 init1: 456 opt: 456 Z-score: 571.0 bits: 111.7 E(85289): 4.6e-25 Smith-Waterman score: 456; 46.5% identity (72.9% similar) in 144 aa overlap (6-149:4-147) 10 20 30 40 50 60 pF1KB8 MAGLPRRIIKETQRLLAEPVPGIKAEPDESNARYFHVVIAGPQDSPFEGGTFKLELFLPE .:: :: . : .: .: : .. .....: ::.:::..::.: : . .: NP_871 MALKRINKELSDLARDPPAQCSAGPVGDDMFHWQATIMGPNDSPYQGGVFFLTIHFPT 10 20 30 40 50 70 80 90 100 110 120 pF1KB8 EYPMAAPKVRFMTKIYHPNVDKLGRICLDILKDKWSPALQIRTVLLSIQALLSAPNPDDP .::. ::: : :.:::::... : ::::::...::::: : ::::: .:: :::::: NP_871 DYPFKPPKVAFTTRIYHPNINSNGSICLDILRSQWSPALTISKVLLSICSLLCDPNPDDP 60 70 80 90 100 110 130 140 150 pF1KB8 LANDVAEQWKTNEAQAIETARAWTRLYAMNNI :. ..:. .::.. . . .: ::. ::: NP_871 LVPEIARIYKTDRDKYNRISREWTQKYAM 120 130 140 >>NP_871615 (OMIM: 602963) ubiquitin-conjugating enzyme (147 aa) initn: 456 init1: 456 opt: 456 Z-score: 571.0 bits: 111.7 E(85289): 4.6e-25 Smith-Waterman score: 456; 46.5% identity (72.9% similar) in 144 aa overlap (6-149:4-147) 10 20 30 40 50 60 pF1KB8 MAGLPRRIIKETQRLLAEPVPGIKAEPDESNARYFHVVIAGPQDSPFEGGTFKLELFLPE .:: :: . : .: .: : .. .....: ::.:::..::.: : . .: NP_871 MALKRINKELSDLARDPPAQCSAGPVGDDMFHWQATIMGPNDSPYQGGVFFLTIHFPT 10 20 30 40 50 70 80 90 100 110 120 pF1KB8 EYPMAAPKVRFMTKIYHPNVDKLGRICLDILKDKWSPALQIRTVLLSIQALLSAPNPDDP .::. ::: : :.:::::... : ::::::...::::: : ::::: .:: :::::: NP_871 DYPFKPPKVAFTTRIYHPNINSNGSICLDILRSQWSPALTISKVLLSICSLLCDPNPDDP 60 70 80 90 100 110 130 140 150 pF1KB8 LANDVAEQWKTNEAQAIETARAWTRLYAMNNI :. ..:. .::.. . . .: ::. ::: NP_871 LVPEIARIYKTDRDKYNRISREWTQKYAM 120 130 140 >>NP_871620 (OMIM: 602963) ubiquitin-conjugating enzyme (147 aa) initn: 456 init1: 456 opt: 456 Z-score: 571.0 bits: 111.7 E(85289): 4.6e-25 Smith-Waterman score: 456; 46.5% identity (72.9% similar) in 144 aa overlap (6-149:4-147) 10 20 30 40 50 60 pF1KB8 MAGLPRRIIKETQRLLAEPVPGIKAEPDESNARYFHVVIAGPQDSPFEGGTFKLELFLPE .:: :: . : .: .: : .. .....: ::.:::..::.: : . .: NP_871 MALKRINKELSDLARDPPAQCSAGPVGDDMFHWQATIMGPNDSPYQGGVFFLTIHFPT 10 20 30 40 50 70 80 90 100 110 120 pF1KB8 EYPMAAPKVRFMTKIYHPNVDKLGRICLDILKDKWSPALQIRTVLLSIQALLSAPNPDDP .::. ::: : :.:::::... : ::::::...::::: : ::::: .:: :::::: NP_871 DYPFKPPKVAFTTRIYHPNINSNGSICLDILRSQWSPALTISKVLLSICSLLCDPNPDDP 60 70 80 90 100 110 130 140 150 pF1KB8 LANDVAEQWKTNEAQAIETARAWTRLYAMNNI :. ..:. .::.. . . .: ::. ::: NP_871 LVPEIARIYKTDRDKYNRISREWTQKYAM 120 130 140 >>NP_003331 (OMIM: 602963) ubiquitin-conjugating enzyme (147 aa) initn: 456 init1: 456 opt: 456 Z-score: 571.0 bits: 111.7 E(85289): 4.6e-25 Smith-Waterman score: 456; 46.5% identity (72.9% similar) in 144 aa overlap (6-149:4-147) 10 20 30 40 50 60 pF1KB8 MAGLPRRIIKETQRLLAEPVPGIKAEPDESNARYFHVVIAGPQDSPFEGGTFKLELFLPE .:: :: . : .: .: : .. .....: ::.:::..::.: : . .: NP_003 MALKRINKELSDLARDPPAQCSAGPVGDDMFHWQATIMGPNDSPYQGGVFFLTIHFPT 10 20 30 40 50 70 80 90 100 110 120 pF1KB8 EYPMAAPKVRFMTKIYHPNVDKLGRICLDILKDKWSPALQIRTVLLSIQALLSAPNPDDP .::. ::: : :.:::::... : ::::::...::::: : ::::: .:: :::::: NP_003 DYPFKPPKVAFTTRIYHPNINSNGSICLDILRSQWSPALTISKVLLSICSLLCDPNPDDP 60 70 80 90 100 110 130 140 150 pF1KB8 LANDVAEQWKTNEAQAIETARAWTRLYAMNNI :. ..:. .::.. . . .: ::. ::: NP_003 LVPEIARIYKTDRDKYNRISREWTQKYAM 120 130 140 152 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 09:37:54 2016 done: Fri Nov 4 09:37:54 2016 Total Scan time: 4.110 Total Display time: -0.030 Function used was FASTA [36.3.4 Apr, 2011]