FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8122, 214 aa 1>>>pF1KB8122 214 - 214 aa - 214 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 9.0466+/-0.000351; mu= -2.1529+/- 0.022 mean_var=236.6351+/-46.782, 0's: 0 Z-trim(121.9): 20 B-trim: 320 in 1/55 Lambda= 0.083375 statistics sampled from 39073 (39093) to 39073 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.781), E-opt: 0.2 (0.458), width: 16 Scan time: 5.830 The best scores are: opt bits E(85289) NP_877724 (OMIM: 608073) nucleoplasmin-2 isoform 1 ( 214) 1380 177.9 1.1e-44 XP_016868438 (OMIM: 608073) PREDICTED: nucleoplasm ( 214) 1380 177.9 1.1e-44 XP_011542664 (OMIM: 608073) PREDICTED: nucleoplasm ( 214) 1380 177.9 1.1e-44 XP_016868437 (OMIM: 608073) PREDICTED: nucleoplasm ( 214) 1380 177.9 1.1e-44 NP_001273609 (OMIM: 608073) nucleoplasmin-2 isofor ( 214) 1380 177.9 1.1e-44 XP_011542665 (OMIM: 608073) PREDICTED: nucleoplasm ( 214) 1380 177.9 1.1e-44 XP_011542662 (OMIM: 608073) PREDICTED: nucleoplasm ( 289) 1268 164.5 1.6e-40 XP_011542666 (OMIM: 608073) PREDICTED: nucleoplasm ( 156) 994 131.3 8.4e-31 NP_001273610 (OMIM: 608073) nucleoplasmin-2 isofor ( 136) 804 108.4 5.8e-24 XP_016868439 (OMIM: 608073) PREDICTED: nucleoplasm ( 172) 789 106.7 2.4e-23 XP_016868436 (OMIM: 608073) PREDICTED: nucleoplasm ( 247) 789 106.8 3.2e-23 NP_008924 (OMIM: 606456) nucleoplasmin-3 [Homo sap ( 178) 304 48.4 9e-06 XP_005265977 (OMIM: 164040) PREDICTED: nucleophosm ( 230) 257 42.8 0.00055 NP_954654 (OMIM: 164040) nucleophosmin isoform 2 [ ( 265) 257 42.8 0.00061 NP_001032827 (OMIM: 164040) nucleophosmin isoform ( 259) 255 42.6 0.00071 NP_002511 (OMIM: 164040) nucleophosmin isoform 1 [ ( 294) 255 42.6 0.00078 >>NP_877724 (OMIM: 608073) nucleoplasmin-2 isoform 1 [Ho (214 aa) initn: 1380 init1: 1380 opt: 1380 Z-score: 923.0 bits: 177.9 E(85289): 1.1e-44 Smith-Waterman score: 1380; 100.0% identity (100.0% similar) in 214 aa overlap (1-214:1-214) 10 20 30 40 50 60 pF1KB8 MNLSSASSTEEKAVTTVLWGCELSQERRTWTFRPQLEGKQSCRLLLHTICLGEKAKEEMH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_877 MNLSSASSTEEKAVTTVLWGCELSQERRTWTFRPQLEGKQSCRLLLHTICLGEKAKEEMH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 RVEILPPANQEDKKMQPVTIASLQASVLPMVSMVGVQLSPPVTFQLRAGSGPVFLSGQER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_877 RVEILPPANQEDKKMQPVTIASLQASVLPMVSMVGVQLSPPVTFQLRAGSGPVFLSGQER 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 YEASDLTWEEEEEEEGEEEEEEEEDDEDEDADISLEEQSPVKQVKRLVPQKQASVAKKKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_877 YEASDLTWEEEEEEEGEEEEEEEEDDEDEDADISLEEQSPVKQVKRLVPQKQASVAKKKK 130 140 150 160 170 180 190 200 210 pF1KB8 LEKEEEEIRASVRDKSPVKKAKATARAKKPGFKK :::::::::::::::::::::::::::::::::: NP_877 LEKEEEEIRASVRDKSPVKKAKATARAKKPGFKK 190 200 210 >>XP_016868438 (OMIM: 608073) PREDICTED: nucleoplasmin-2 (214 aa) initn: 1380 init1: 1380 opt: 1380 Z-score: 923.0 bits: 177.9 E(85289): 1.1e-44 Smith-Waterman score: 1380; 100.0% identity (100.0% similar) in 214 aa overlap (1-214:1-214) 10 20 30 40 50 60 pF1KB8 MNLSSASSTEEKAVTTVLWGCELSQERRTWTFRPQLEGKQSCRLLLHTICLGEKAKEEMH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MNLSSASSTEEKAVTTVLWGCELSQERRTWTFRPQLEGKQSCRLLLHTICLGEKAKEEMH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 RVEILPPANQEDKKMQPVTIASLQASVLPMVSMVGVQLSPPVTFQLRAGSGPVFLSGQER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RVEILPPANQEDKKMQPVTIASLQASVLPMVSMVGVQLSPPVTFQLRAGSGPVFLSGQER 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 YEASDLTWEEEEEEEGEEEEEEEEDDEDEDADISLEEQSPVKQVKRLVPQKQASVAKKKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YEASDLTWEEEEEEEGEEEEEEEEDDEDEDADISLEEQSPVKQVKRLVPQKQASVAKKKK 130 140 150 160 170 180 190 200 210 pF1KB8 LEKEEEEIRASVRDKSPVKKAKATARAKKPGFKK :::::::::::::::::::::::::::::::::: XP_016 LEKEEEEIRASVRDKSPVKKAKATARAKKPGFKK 190 200 210 >>XP_011542664 (OMIM: 608073) PREDICTED: nucleoplasmin-2 (214 aa) initn: 1380 init1: 1380 opt: 1380 Z-score: 923.0 bits: 177.9 E(85289): 1.1e-44 Smith-Waterman score: 1380; 100.0% identity (100.0% similar) in 214 aa overlap (1-214:1-214) 10 20 30 40 50 60 pF1KB8 MNLSSASSTEEKAVTTVLWGCELSQERRTWTFRPQLEGKQSCRLLLHTICLGEKAKEEMH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MNLSSASSTEEKAVTTVLWGCELSQERRTWTFRPQLEGKQSCRLLLHTICLGEKAKEEMH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 RVEILPPANQEDKKMQPVTIASLQASVLPMVSMVGVQLSPPVTFQLRAGSGPVFLSGQER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RVEILPPANQEDKKMQPVTIASLQASVLPMVSMVGVQLSPPVTFQLRAGSGPVFLSGQER 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 YEASDLTWEEEEEEEGEEEEEEEEDDEDEDADISLEEQSPVKQVKRLVPQKQASVAKKKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YEASDLTWEEEEEEEGEEEEEEEEDDEDEDADISLEEQSPVKQVKRLVPQKQASVAKKKK 130 140 150 160 170 180 190 200 210 pF1KB8 LEKEEEEIRASVRDKSPVKKAKATARAKKPGFKK :::::::::::::::::::::::::::::::::: XP_011 LEKEEEEIRASVRDKSPVKKAKATARAKKPGFKK 190 200 210 >>XP_016868437 (OMIM: 608073) PREDICTED: nucleoplasmin-2 (214 aa) initn: 1380 init1: 1380 opt: 1380 Z-score: 923.0 bits: 177.9 E(85289): 1.1e-44 Smith-Waterman score: 1380; 100.0% identity (100.0% similar) in 214 aa overlap (1-214:1-214) 10 20 30 40 50 60 pF1KB8 MNLSSASSTEEKAVTTVLWGCELSQERRTWTFRPQLEGKQSCRLLLHTICLGEKAKEEMH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MNLSSASSTEEKAVTTVLWGCELSQERRTWTFRPQLEGKQSCRLLLHTICLGEKAKEEMH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 RVEILPPANQEDKKMQPVTIASLQASVLPMVSMVGVQLSPPVTFQLRAGSGPVFLSGQER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RVEILPPANQEDKKMQPVTIASLQASVLPMVSMVGVQLSPPVTFQLRAGSGPVFLSGQER 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 YEASDLTWEEEEEEEGEEEEEEEEDDEDEDADISLEEQSPVKQVKRLVPQKQASVAKKKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YEASDLTWEEEEEEEGEEEEEEEEDDEDEDADISLEEQSPVKQVKRLVPQKQASVAKKKK 130 140 150 160 170 180 190 200 210 pF1KB8 LEKEEEEIRASVRDKSPVKKAKATARAKKPGFKK :::::::::::::::::::::::::::::::::: XP_016 LEKEEEEIRASVRDKSPVKKAKATARAKKPGFKK 190 200 210 >>NP_001273609 (OMIM: 608073) nucleoplasmin-2 isoform 1 (214 aa) initn: 1380 init1: 1380 opt: 1380 Z-score: 923.0 bits: 177.9 E(85289): 1.1e-44 Smith-Waterman score: 1380; 100.0% identity (100.0% similar) in 214 aa overlap (1-214:1-214) 10 20 30 40 50 60 pF1KB8 MNLSSASSTEEKAVTTVLWGCELSQERRTWTFRPQLEGKQSCRLLLHTICLGEKAKEEMH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MNLSSASSTEEKAVTTVLWGCELSQERRTWTFRPQLEGKQSCRLLLHTICLGEKAKEEMH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 RVEILPPANQEDKKMQPVTIASLQASVLPMVSMVGVQLSPPVTFQLRAGSGPVFLSGQER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RVEILPPANQEDKKMQPVTIASLQASVLPMVSMVGVQLSPPVTFQLRAGSGPVFLSGQER 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 YEASDLTWEEEEEEEGEEEEEEEEDDEDEDADISLEEQSPVKQVKRLVPQKQASVAKKKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YEASDLTWEEEEEEEGEEEEEEEEDDEDEDADISLEEQSPVKQVKRLVPQKQASVAKKKK 130 140 150 160 170 180 190 200 210 pF1KB8 LEKEEEEIRASVRDKSPVKKAKATARAKKPGFKK :::::::::::::::::::::::::::::::::: NP_001 LEKEEEEIRASVRDKSPVKKAKATARAKKPGFKK 190 200 210 >>XP_011542665 (OMIM: 608073) PREDICTED: nucleoplasmin-2 (214 aa) initn: 1380 init1: 1380 opt: 1380 Z-score: 923.0 bits: 177.9 E(85289): 1.1e-44 Smith-Waterman score: 1380; 100.0% identity (100.0% similar) in 214 aa overlap (1-214:1-214) 10 20 30 40 50 60 pF1KB8 MNLSSASSTEEKAVTTVLWGCELSQERRTWTFRPQLEGKQSCRLLLHTICLGEKAKEEMH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MNLSSASSTEEKAVTTVLWGCELSQERRTWTFRPQLEGKQSCRLLLHTICLGEKAKEEMH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 RVEILPPANQEDKKMQPVTIASLQASVLPMVSMVGVQLSPPVTFQLRAGSGPVFLSGQER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RVEILPPANQEDKKMQPVTIASLQASVLPMVSMVGVQLSPPVTFQLRAGSGPVFLSGQER 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 YEASDLTWEEEEEEEGEEEEEEEEDDEDEDADISLEEQSPVKQVKRLVPQKQASVAKKKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YEASDLTWEEEEEEEGEEEEEEEEDDEDEDADISLEEQSPVKQVKRLVPQKQASVAKKKK 130 140 150 160 170 180 190 200 210 pF1KB8 LEKEEEEIRASVRDKSPVKKAKATARAKKPGFKK :::::::::::::::::::::::::::::::::: XP_011 LEKEEEEIRASVRDKSPVKKAKATARAKKPGFKK 190 200 210 >>XP_011542662 (OMIM: 608073) PREDICTED: nucleoplasmin-2 (289 aa) initn: 1268 init1: 1268 opt: 1268 Z-score: 848.4 bits: 164.5 E(85289): 1.6e-40 Smith-Waterman score: 1268; 100.0% identity (100.0% similar) in 195 aa overlap (20-214:95-289) 10 20 30 40 pF1KB8 MNLSSASSTEEKAVTTVLWGCELSQERRTWTFRPQLEGKQSCRLLLHTI :::::::::::::::::::::::::::::: XP_011 PPGSPPHPTCPLRLSAGDLTVLETGLARSHGCELSQERRTWTFRPQLEGKQSCRLLLHTI 70 80 90 100 110 120 50 60 70 80 90 100 pF1KB8 CLGEKAKEEMHRVEILPPANQEDKKMQPVTIASLQASVLPMVSMVGVQLSPPVTFQLRAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CLGEKAKEEMHRVEILPPANQEDKKMQPVTIASLQASVLPMVSMVGVQLSPPVTFQLRAG 130 140 150 160 170 180 110 120 130 140 150 160 pF1KB8 SGPVFLSGQERYEASDLTWEEEEEEEGEEEEEEEEDDEDEDADISLEEQSPVKQVKRLVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SGPVFLSGQERYEASDLTWEEEEEEEGEEEEEEEEDDEDEDADISLEEQSPVKQVKRLVP 190 200 210 220 230 240 170 180 190 200 210 pF1KB8 QKQASVAKKKKLEKEEEEIRASVRDKSPVKKAKATARAKKPGFKK ::::::::::::::::::::::::::::::::::::::::::::: XP_011 QKQASVAKKKKLEKEEEEIRASVRDKSPVKKAKATARAKKPGFKK 250 260 270 280 >>XP_011542666 (OMIM: 608073) PREDICTED: nucleoplasmin-2 (156 aa) initn: 994 init1: 994 opt: 994 Z-score: 674.0 bits: 131.3 E(85289): 8.4e-31 Smith-Waterman score: 994; 100.0% identity (100.0% similar) in 156 aa overlap (59-214:1-156) 30 40 50 60 70 80 pF1KB8 TWTFRPQLEGKQSCRLLLHTICLGEKAKEEMHRVEILPPANQEDKKMQPVTIASLQASVL :::::::::::::::::::::::::::::: XP_011 MHRVEILPPANQEDKKMQPVTIASLQASVL 10 20 30 90 100 110 120 130 140 pF1KB8 PMVSMVGVQLSPPVTFQLRAGSGPVFLSGQERYEASDLTWEEEEEEEGEEEEEEEEDDED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PMVSMVGVQLSPPVTFQLRAGSGPVFLSGQERYEASDLTWEEEEEEEGEEEEEEEEDDED 40 50 60 70 80 90 150 160 170 180 190 200 pF1KB8 EDADISLEEQSPVKQVKRLVPQKQASVAKKKKLEKEEEEIRASVRDKSPVKKAKATARAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EDADISLEEQSPVKQVKRLVPQKQASVAKKKKLEKEEEEIRASVRDKSPVKKAKATARAK 100 110 120 130 140 150 210 pF1KB8 KPGFKK :::::: XP_011 KPGFKK >>NP_001273610 (OMIM: 608073) nucleoplasmin-2 isoform 2 (136 aa) initn: 804 init1: 804 opt: 804 Z-score: 551.2 bits: 108.4 E(85289): 5.8e-24 Smith-Waterman score: 804; 100.0% identity (100.0% similar) in 122 aa overlap (1-122:1-122) 10 20 30 40 50 60 pF1KB8 MNLSSASSTEEKAVTTVLWGCELSQERRTWTFRPQLEGKQSCRLLLHTICLGEKAKEEMH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MNLSSASSTEEKAVTTVLWGCELSQERRTWTFRPQLEGKQSCRLLLHTICLGEKAKEEMH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 RVEILPPANQEDKKMQPVTIASLQASVLPMVSMVGVQLSPPVTFQLRAGSGPVFLSGQER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RVEILPPANQEDKKMQPVTIASLQASVLPMVSMVGVQLSPPVTFQLRAGSGPVFLSGQER 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 YEASDLTWEEEEEEEGEEEEEEEEDDEDEDADISLEEQSPVKQVKRLVPQKQASVAKKKK :: NP_001 YEKKAGKRRRGNKSQR 130 >>XP_016868439 (OMIM: 608073) PREDICTED: nucleoplasmin-2 (172 aa) initn: 789 init1: 789 opt: 789 Z-score: 540.1 bits: 106.7 E(85289): 2.4e-23 Smith-Waterman score: 1012; 80.4% identity (80.4% similar) in 214 aa overlap (1-214:1-172) 10 20 30 40 50 60 pF1KB8 MNLSSASSTEEKAVTTVLWGCELSQERRTWTFRPQLEGKQSCRLLLHTICLGEKAKEEMH :::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MNLSSASSTEEKAVTTVLWGCELSQERRTWTFRPQLEGKQSCRLLLHT------------ 10 20 30 40 70 80 90 100 110 120 pF1KB8 RVEILPPANQEDKKMQPVTIASLQASVLPMVSMVGVQLSPPVTFQLRAGSGPVFLSGQER :::::::::::::::::::::::::::::: XP_016 ------------------------------VSMVGVQLSPPVTFQLRAGSGPVFLSGQER 50 60 70 130 140 150 160 170 180 pF1KB8 YEASDLTWEEEEEEEGEEEEEEEEDDEDEDADISLEEQSPVKQVKRLVPQKQASVAKKKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YEASDLTWEEEEEEEGEEEEEEEEDDEDEDADISLEEQSPVKQVKRLVPQKQASVAKKKK 80 90 100 110 120 130 190 200 210 pF1KB8 LEKEEEEIRASVRDKSPVKKAKATARAKKPGFKK :::::::::::::::::::::::::::::::::: XP_016 LEKEEEEIRASVRDKSPVKKAKATARAKKPGFKK 140 150 160 170 214 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 09:43:59 2016 done: Fri Nov 4 09:44:00 2016 Total Scan time: 5.830 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]