FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8123, 517 aa 1>>>pF1KB8123 517 - 517 aa - 517 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.9971+/-0.000546; mu= 9.1018+/- 0.033 mean_var=158.1272+/-32.914, 0's: 0 Z-trim(111.4): 289 B-trim: 495 in 2/52 Lambda= 0.101993 statistics sampled from 19581 (19998) to 19581 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.601), E-opt: 0.2 (0.234), width: 16 Scan time: 7.790 The best scores are: opt bits E(85289) NP_061840 (OMIM: 608714) gamma-1-syntrophin isofor ( 517) 3483 525.7 1.3e-148 XP_016869069 (OMIM: 608714) PREDICTED: gamma-1-syn ( 517) 3483 525.7 1.3e-148 XP_016869068 (OMIM: 608714) PREDICTED: gamma-1-syn ( 517) 3483 525.7 1.3e-148 NP_001308702 (OMIM: 608714) gamma-1-syntrophin iso ( 517) 3483 525.7 1.3e-148 NP_001274742 (OMIM: 608714) gamma-1-syntrophin iso ( 517) 3483 525.7 1.3e-148 XP_011515850 (OMIM: 608714) PREDICTED: gamma-1-syn ( 472) 3112 471.1 3.3e-132 NP_001274743 (OMIM: 608714) gamma-1-syntrophin iso ( 480) 2915 442.1 1.8e-123 NP_001308706 (OMIM: 608714) gamma-1-syntrophin iso ( 435) 2913 441.7 2e-123 NP_001308705 (OMIM: 608714) gamma-1-syntrophin iso ( 435) 2913 441.7 2e-123 NP_001308704 (OMIM: 608714) gamma-1-syntrophin iso ( 435) 2913 441.7 2e-123 NP_001308707 (OMIM: 608714) gamma-1-syntrophin iso ( 435) 2913 441.7 2e-123 XP_016869071 (OMIM: 608714) PREDICTED: gamma-1-syn ( 304) 1831 282.4 1.3e-75 XP_016869070 (OMIM: 608714) PREDICTED: gamma-1-syn ( 316) 1831 282.4 1.4e-75 XP_016859855 (OMIM: 608715) PREDICTED: gamma-2-syn ( 436) 1115 177.2 8.9e-44 XP_016859854 (OMIM: 608715) PREDICTED: gamma-2-syn ( 437) 1115 177.2 8.9e-44 XP_016859851 (OMIM: 608715) PREDICTED: gamma-2-syn ( 537) 1115 177.3 1e-43 XP_016859857 (OMIM: 608715) PREDICTED: gamma-2-syn ( 349) 1029 164.4 4.9e-40 XP_016859859 (OMIM: 608715) PREDICTED: gamma-2-syn ( 337) 1028 164.3 5.3e-40 XP_016859858 (OMIM: 608715) PREDICTED: gamma-2-syn ( 345) 1028 164.3 5.4e-40 XP_016859861 (OMIM: 608715) PREDICTED: gamma-2-syn ( 317) 914 147.5 5.7e-35 XP_016859860 (OMIM: 608715) PREDICTED: gamma-2-syn ( 317) 914 147.5 5.7e-35 XP_016859863 (OMIM: 608715) PREDICTED: gamma-2-syn ( 270) 669 111.4 3.6e-24 XP_016859862 (OMIM: 608715) PREDICTED: gamma-2-syn ( 314) 637 106.7 1e-22 XP_016859856 (OMIM: 608715) PREDICTED: gamma-2-syn ( 426) 637 106.8 1.3e-22 XP_011508668 (OMIM: 608715) PREDICTED: gamma-2-syn ( 426) 637 106.8 1.3e-22 XP_016859853 (OMIM: 608715) PREDICTED: gamma-2-syn ( 466) 637 106.9 1.4e-22 XP_016859852 (OMIM: 608715) PREDICTED: gamma-2-syn ( 480) 637 106.9 1.4e-22 NP_061841 (OMIM: 608715) gamma-2-syntrophin [Homo ( 539) 637 106.9 1.5e-22 XP_016859850 (OMIM: 608715) PREDICTED: gamma-2-syn ( 540) 637 106.9 1.5e-22 XP_011515541 (OMIM: 600026) PREDICTED: beta-1-synt ( 382) 296 56.6 1.5e-07 NP_066301 (OMIM: 600026) beta-1-syntrophin [Homo s ( 538) 296 56.8 2e-07 XP_011527310 (OMIM: 601017,612955) PREDICTED: alph ( 495) 282 54.7 7.7e-07 XP_011527309 (OMIM: 601017,612955) PREDICTED: alph ( 496) 282 54.7 7.7e-07 XP_005260574 (OMIM: 601017,612955) PREDICTED: alph ( 504) 282 54.7 7.8e-07 NP_003089 (OMIM: 601017,612955) alpha-1-syntrophin ( 505) 282 54.7 7.8e-07 NP_006741 (OMIM: 600027) beta-2-syntrophin [Homo s ( 540) 278 54.1 1.2e-06 NP_001017408 (OMIM: 606845) Golgi-associated PDZ a ( 454) 222 45.8 0.00033 NP_065132 (OMIM: 606845) Golgi-associated PDZ and ( 462) 222 45.8 0.00033 NP_001288057 (OMIM: 606382) membrane-associated gu (1441) 209 44.4 0.0028 NP_036433 (OMIM: 606382) membrane-associated guany (1455) 209 44.4 0.0028 XP_016868333 (OMIM: 606382) PREDICTED: membrane-as (1498) 209 44.4 0.0029 XP_011532543 (OMIM: 602625) PREDICTED: membrane-as ( 746) 198 42.5 0.0054 XP_011532542 (OMIM: 602625) PREDICTED: membrane-as ( 774) 198 42.5 0.0056 XP_016862995 (OMIM: 602625) PREDICTED: membrane-as (1276) 200 43.0 0.0065 NP_056335 (OMIM: 602625) membrane-associated guany (1287) 200 43.0 0.0065 XP_016862994 (OMIM: 602625) PREDICTED: membrane-as (1288) 200 43.0 0.0065 XP_016862993 (OMIM: 602625) PREDICTED: membrane-as (1288) 200 43.0 0.0065 XP_005265631 (OMIM: 602625) PREDICTED: membrane-as (1288) 200 43.0 0.0065 XP_016862991 (OMIM: 602625) PREDICTED: membrane-as (1289) 200 43.0 0.0065 XP_016862992 (OMIM: 602625) PREDICTED: membrane-as (1289) 200 43.0 0.0065 >>NP_061840 (OMIM: 608714) gamma-1-syntrophin isoform 1 (517 aa) initn: 3483 init1: 3483 opt: 3483 Z-score: 2789.1 bits: 525.7 E(85289): 1.3e-148 Smith-Waterman score: 3483; 100.0% identity (100.0% similar) in 517 aa overlap (1-517:1-517) 10 20 30 40 50 60 pF1KB8 MDFRTACEETKTGICLLQDGNQEPFKVRLHLAKDILMIQEQDVICVSGEPFYSGERTVTI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 MDFRTACEETKTGICLLQDGNQEPFKVRLHLAKDILMIQEQDVICVSGEPFYSGERTVTI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 RRQTVGGFGLSIKGGAEHNIPVVVSKISKEQRAELSGLLFIGDAILQINGINVRKCRHEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 RRQTVGGFGLSIKGGAEHNIPVVVSKISKEQRAELSGLLFIGDAILQINGINVRKCRHEE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 VVQVLRNAGEEVTLTVSFLKRAPAFLKLPLNEDCACAPSDQSSGTSSPLCDSGLHLNYHP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 VVQVLRNAGEEVTLTVSFLKRAPAFLKLPLNEDCACAPSDQSSGTSSPLCDSGLHLNYHP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 NNTDTLSCSSWPTSPGLRWEKRWCDLRLIPLLHSRFSQYVPGTDLSRQNAFQVIAVDGVC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 NNTDTLSCSSWPTSPGLRWEKRWCDLRLIPLLHSRFSQYVPGTDLSRQNAFQVIAVDGVC 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 TGIIQCLSAEDCVDWLQAIATNISNLTKHNIKKINRNFPVNQQIVYMGWCEAREQDPLQD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 TGIIQCLSAEDCVDWLQAIATNISNLTKHNIKKINRNFPVNQQIVYMGWCEAREQDPLQD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 RVYSPTFLALRGSCLYKFLAPPVTTWDWTRAEKTFSVYEIMCKILKDSDLLDRRKQCFTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 RVYSPTFLALRGSCLYKFLAPPVTTWDWTRAEKTFSVYEIMCKILKDSDLLDRRKQCFTV 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 QSESGEDLYFSVELESDLAQWERAFQTATFLEVERIQCKTYACVLESHLMGLTIDFSTGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 QSESGEDLYFSVELESDLAQWERAFQTATFLEVERIQCKTYACVLESHLMGLTIDFSTGF 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB8 ICFDAATKAVLWRYKFSQLKGSSDDGKSKIKFLFQNPDTKQIEAKELEFSNLFAVLHCIH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 ICFDAATKAVLWRYKFSQLKGSSDDGKSKIKFLFQNPDTKQIEAKELEFSNLFAVLHCIH 430 440 450 460 470 480 490 500 510 pF1KB8 SFFAAKVACLDPLFLGNQATASTAASSATTSKAKYTT ::::::::::::::::::::::::::::::::::::: NP_061 SFFAAKVACLDPLFLGNQATASTAASSATTSKAKYTT 490 500 510 >>XP_016869069 (OMIM: 608714) PREDICTED: gamma-1-syntrop (517 aa) initn: 3483 init1: 3483 opt: 3483 Z-score: 2789.1 bits: 525.7 E(85289): 1.3e-148 Smith-Waterman score: 3483; 100.0% identity (100.0% similar) in 517 aa overlap (1-517:1-517) 10 20 30 40 50 60 pF1KB8 MDFRTACEETKTGICLLQDGNQEPFKVRLHLAKDILMIQEQDVICVSGEPFYSGERTVTI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MDFRTACEETKTGICLLQDGNQEPFKVRLHLAKDILMIQEQDVICVSGEPFYSGERTVTI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 RRQTVGGFGLSIKGGAEHNIPVVVSKISKEQRAELSGLLFIGDAILQINGINVRKCRHEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RRQTVGGFGLSIKGGAEHNIPVVVSKISKEQRAELSGLLFIGDAILQINGINVRKCRHEE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 VVQVLRNAGEEVTLTVSFLKRAPAFLKLPLNEDCACAPSDQSSGTSSPLCDSGLHLNYHP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VVQVLRNAGEEVTLTVSFLKRAPAFLKLPLNEDCACAPSDQSSGTSSPLCDSGLHLNYHP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 NNTDTLSCSSWPTSPGLRWEKRWCDLRLIPLLHSRFSQYVPGTDLSRQNAFQVIAVDGVC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NNTDTLSCSSWPTSPGLRWEKRWCDLRLIPLLHSRFSQYVPGTDLSRQNAFQVIAVDGVC 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 TGIIQCLSAEDCVDWLQAIATNISNLTKHNIKKINRNFPVNQQIVYMGWCEAREQDPLQD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TGIIQCLSAEDCVDWLQAIATNISNLTKHNIKKINRNFPVNQQIVYMGWCEAREQDPLQD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 RVYSPTFLALRGSCLYKFLAPPVTTWDWTRAEKTFSVYEIMCKILKDSDLLDRRKQCFTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RVYSPTFLALRGSCLYKFLAPPVTTWDWTRAEKTFSVYEIMCKILKDSDLLDRRKQCFTV 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 QSESGEDLYFSVELESDLAQWERAFQTATFLEVERIQCKTYACVLESHLMGLTIDFSTGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QSESGEDLYFSVELESDLAQWERAFQTATFLEVERIQCKTYACVLESHLMGLTIDFSTGF 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB8 ICFDAATKAVLWRYKFSQLKGSSDDGKSKIKFLFQNPDTKQIEAKELEFSNLFAVLHCIH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ICFDAATKAVLWRYKFSQLKGSSDDGKSKIKFLFQNPDTKQIEAKELEFSNLFAVLHCIH 430 440 450 460 470 480 490 500 510 pF1KB8 SFFAAKVACLDPLFLGNQATASTAASSATTSKAKYTT ::::::::::::::::::::::::::::::::::::: XP_016 SFFAAKVACLDPLFLGNQATASTAASSATTSKAKYTT 490 500 510 >>XP_016869068 (OMIM: 608714) PREDICTED: gamma-1-syntrop (517 aa) initn: 3483 init1: 3483 opt: 3483 Z-score: 2789.1 bits: 525.7 E(85289): 1.3e-148 Smith-Waterman score: 3483; 100.0% identity (100.0% similar) in 517 aa overlap (1-517:1-517) 10 20 30 40 50 60 pF1KB8 MDFRTACEETKTGICLLQDGNQEPFKVRLHLAKDILMIQEQDVICVSGEPFYSGERTVTI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MDFRTACEETKTGICLLQDGNQEPFKVRLHLAKDILMIQEQDVICVSGEPFYSGERTVTI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 RRQTVGGFGLSIKGGAEHNIPVVVSKISKEQRAELSGLLFIGDAILQINGINVRKCRHEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RRQTVGGFGLSIKGGAEHNIPVVVSKISKEQRAELSGLLFIGDAILQINGINVRKCRHEE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 VVQVLRNAGEEVTLTVSFLKRAPAFLKLPLNEDCACAPSDQSSGTSSPLCDSGLHLNYHP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VVQVLRNAGEEVTLTVSFLKRAPAFLKLPLNEDCACAPSDQSSGTSSPLCDSGLHLNYHP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 NNTDTLSCSSWPTSPGLRWEKRWCDLRLIPLLHSRFSQYVPGTDLSRQNAFQVIAVDGVC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NNTDTLSCSSWPTSPGLRWEKRWCDLRLIPLLHSRFSQYVPGTDLSRQNAFQVIAVDGVC 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 TGIIQCLSAEDCVDWLQAIATNISNLTKHNIKKINRNFPVNQQIVYMGWCEAREQDPLQD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TGIIQCLSAEDCVDWLQAIATNISNLTKHNIKKINRNFPVNQQIVYMGWCEAREQDPLQD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 RVYSPTFLALRGSCLYKFLAPPVTTWDWTRAEKTFSVYEIMCKILKDSDLLDRRKQCFTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RVYSPTFLALRGSCLYKFLAPPVTTWDWTRAEKTFSVYEIMCKILKDSDLLDRRKQCFTV 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 QSESGEDLYFSVELESDLAQWERAFQTATFLEVERIQCKTYACVLESHLMGLTIDFSTGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QSESGEDLYFSVELESDLAQWERAFQTATFLEVERIQCKTYACVLESHLMGLTIDFSTGF 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB8 ICFDAATKAVLWRYKFSQLKGSSDDGKSKIKFLFQNPDTKQIEAKELEFSNLFAVLHCIH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ICFDAATKAVLWRYKFSQLKGSSDDGKSKIKFLFQNPDTKQIEAKELEFSNLFAVLHCIH 430 440 450 460 470 480 490 500 510 pF1KB8 SFFAAKVACLDPLFLGNQATASTAASSATTSKAKYTT ::::::::::::::::::::::::::::::::::::: XP_016 SFFAAKVACLDPLFLGNQATASTAASSATTSKAKYTT 490 500 510 >>NP_001308702 (OMIM: 608714) gamma-1-syntrophin isoform (517 aa) initn: 3483 init1: 3483 opt: 3483 Z-score: 2789.1 bits: 525.7 E(85289): 1.3e-148 Smith-Waterman score: 3483; 100.0% identity (100.0% similar) in 517 aa overlap (1-517:1-517) 10 20 30 40 50 60 pF1KB8 MDFRTACEETKTGICLLQDGNQEPFKVRLHLAKDILMIQEQDVICVSGEPFYSGERTVTI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MDFRTACEETKTGICLLQDGNQEPFKVRLHLAKDILMIQEQDVICVSGEPFYSGERTVTI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 RRQTVGGFGLSIKGGAEHNIPVVVSKISKEQRAELSGLLFIGDAILQINGINVRKCRHEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RRQTVGGFGLSIKGGAEHNIPVVVSKISKEQRAELSGLLFIGDAILQINGINVRKCRHEE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 VVQVLRNAGEEVTLTVSFLKRAPAFLKLPLNEDCACAPSDQSSGTSSPLCDSGLHLNYHP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VVQVLRNAGEEVTLTVSFLKRAPAFLKLPLNEDCACAPSDQSSGTSSPLCDSGLHLNYHP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 NNTDTLSCSSWPTSPGLRWEKRWCDLRLIPLLHSRFSQYVPGTDLSRQNAFQVIAVDGVC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NNTDTLSCSSWPTSPGLRWEKRWCDLRLIPLLHSRFSQYVPGTDLSRQNAFQVIAVDGVC 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 TGIIQCLSAEDCVDWLQAIATNISNLTKHNIKKINRNFPVNQQIVYMGWCEAREQDPLQD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TGIIQCLSAEDCVDWLQAIATNISNLTKHNIKKINRNFPVNQQIVYMGWCEAREQDPLQD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 RVYSPTFLALRGSCLYKFLAPPVTTWDWTRAEKTFSVYEIMCKILKDSDLLDRRKQCFTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RVYSPTFLALRGSCLYKFLAPPVTTWDWTRAEKTFSVYEIMCKILKDSDLLDRRKQCFTV 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 QSESGEDLYFSVELESDLAQWERAFQTATFLEVERIQCKTYACVLESHLMGLTIDFSTGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QSESGEDLYFSVELESDLAQWERAFQTATFLEVERIQCKTYACVLESHLMGLTIDFSTGF 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB8 ICFDAATKAVLWRYKFSQLKGSSDDGKSKIKFLFQNPDTKQIEAKELEFSNLFAVLHCIH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ICFDAATKAVLWRYKFSQLKGSSDDGKSKIKFLFQNPDTKQIEAKELEFSNLFAVLHCIH 430 440 450 460 470 480 490 500 510 pF1KB8 SFFAAKVACLDPLFLGNQATASTAASSATTSKAKYTT ::::::::::::::::::::::::::::::::::::: NP_001 SFFAAKVACLDPLFLGNQATASTAASSATTSKAKYTT 490 500 510 >>NP_001274742 (OMIM: 608714) gamma-1-syntrophin isoform (517 aa) initn: 3483 init1: 3483 opt: 3483 Z-score: 2789.1 bits: 525.7 E(85289): 1.3e-148 Smith-Waterman score: 3483; 100.0% identity (100.0% similar) in 517 aa overlap (1-517:1-517) 10 20 30 40 50 60 pF1KB8 MDFRTACEETKTGICLLQDGNQEPFKVRLHLAKDILMIQEQDVICVSGEPFYSGERTVTI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MDFRTACEETKTGICLLQDGNQEPFKVRLHLAKDILMIQEQDVICVSGEPFYSGERTVTI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 RRQTVGGFGLSIKGGAEHNIPVVVSKISKEQRAELSGLLFIGDAILQINGINVRKCRHEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RRQTVGGFGLSIKGGAEHNIPVVVSKISKEQRAELSGLLFIGDAILQINGINVRKCRHEE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 VVQVLRNAGEEVTLTVSFLKRAPAFLKLPLNEDCACAPSDQSSGTSSPLCDSGLHLNYHP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VVQVLRNAGEEVTLTVSFLKRAPAFLKLPLNEDCACAPSDQSSGTSSPLCDSGLHLNYHP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 NNTDTLSCSSWPTSPGLRWEKRWCDLRLIPLLHSRFSQYVPGTDLSRQNAFQVIAVDGVC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NNTDTLSCSSWPTSPGLRWEKRWCDLRLIPLLHSRFSQYVPGTDLSRQNAFQVIAVDGVC 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 TGIIQCLSAEDCVDWLQAIATNISNLTKHNIKKINRNFPVNQQIVYMGWCEAREQDPLQD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TGIIQCLSAEDCVDWLQAIATNISNLTKHNIKKINRNFPVNQQIVYMGWCEAREQDPLQD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 RVYSPTFLALRGSCLYKFLAPPVTTWDWTRAEKTFSVYEIMCKILKDSDLLDRRKQCFTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RVYSPTFLALRGSCLYKFLAPPVTTWDWTRAEKTFSVYEIMCKILKDSDLLDRRKQCFTV 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 QSESGEDLYFSVELESDLAQWERAFQTATFLEVERIQCKTYACVLESHLMGLTIDFSTGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QSESGEDLYFSVELESDLAQWERAFQTATFLEVERIQCKTYACVLESHLMGLTIDFSTGF 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB8 ICFDAATKAVLWRYKFSQLKGSSDDGKSKIKFLFQNPDTKQIEAKELEFSNLFAVLHCIH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ICFDAATKAVLWRYKFSQLKGSSDDGKSKIKFLFQNPDTKQIEAKELEFSNLFAVLHCIH 430 440 450 460 470 480 490 500 510 pF1KB8 SFFAAKVACLDPLFLGNQATASTAASSATTSKAKYTT ::::::::::::::::::::::::::::::::::::: NP_001 SFFAAKVACLDPLFLGNQATASTAASSATTSKAKYTT 490 500 510 >>XP_011515850 (OMIM: 608714) PREDICTED: gamma-1-syntrop (472 aa) initn: 3112 init1: 3112 opt: 3112 Z-score: 2494.6 bits: 471.1 E(85289): 3.3e-132 Smith-Waterman score: 3112; 100.0% identity (100.0% similar) in 463 aa overlap (55-517:10-472) 30 40 50 60 70 80 pF1KB8 FKVRLHLAKDILMIQEQDVICVSGEPFYSGERTVTIRRQTVGGFGLSIKGGAEHNIPVVV :::::::::::::::::::::::::::::: XP_011 MDFRTACEEERTVTIRRQTVGGFGLSIKGGAEHNIPVVV 10 20 30 90 100 110 120 130 140 pF1KB8 SKISKEQRAELSGLLFIGDAILQINGINVRKCRHEEVVQVLRNAGEEVTLTVSFLKRAPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SKISKEQRAELSGLLFIGDAILQINGINVRKCRHEEVVQVLRNAGEEVTLTVSFLKRAPA 40 50 60 70 80 90 150 160 170 180 190 200 pF1KB8 FLKLPLNEDCACAPSDQSSGTSSPLCDSGLHLNYHPNNTDTLSCSSWPTSPGLRWEKRWC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FLKLPLNEDCACAPSDQSSGTSSPLCDSGLHLNYHPNNTDTLSCSSWPTSPGLRWEKRWC 100 110 120 130 140 150 210 220 230 240 250 260 pF1KB8 DLRLIPLLHSRFSQYVPGTDLSRQNAFQVIAVDGVCTGIIQCLSAEDCVDWLQAIATNIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DLRLIPLLHSRFSQYVPGTDLSRQNAFQVIAVDGVCTGIIQCLSAEDCVDWLQAIATNIS 160 170 180 190 200 210 270 280 290 300 310 320 pF1KB8 NLTKHNIKKINRNFPVNQQIVYMGWCEAREQDPLQDRVYSPTFLALRGSCLYKFLAPPVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NLTKHNIKKINRNFPVNQQIVYMGWCEAREQDPLQDRVYSPTFLALRGSCLYKFLAPPVT 220 230 240 250 260 270 330 340 350 360 370 380 pF1KB8 TWDWTRAEKTFSVYEIMCKILKDSDLLDRRKQCFTVQSESGEDLYFSVELESDLAQWERA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TWDWTRAEKTFSVYEIMCKILKDSDLLDRRKQCFTVQSESGEDLYFSVELESDLAQWERA 280 290 300 310 320 330 390 400 410 420 430 440 pF1KB8 FQTATFLEVERIQCKTYACVLESHLMGLTIDFSTGFICFDAATKAVLWRYKFSQLKGSSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FQTATFLEVERIQCKTYACVLESHLMGLTIDFSTGFICFDAATKAVLWRYKFSQLKGSSD 340 350 360 370 380 390 450 460 470 480 490 500 pF1KB8 DGKSKIKFLFQNPDTKQIEAKELEFSNLFAVLHCIHSFFAAKVACLDPLFLGNQATASTA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DGKSKIKFLFQNPDTKQIEAKELEFSNLFAVLHCIHSFFAAKVACLDPLFLGNQATASTA 400 410 420 430 440 450 510 pF1KB8 ASSATTSKAKYTT ::::::::::::: XP_011 ASSATTSKAKYTT 460 470 >>NP_001274743 (OMIM: 608714) gamma-1-syntrophin isoform (480 aa) initn: 2912 init1: 2912 opt: 2915 Z-score: 2337.8 bits: 442.1 E(85289): 1.8e-123 Smith-Waterman score: 3154; 92.8% identity (92.8% similar) in 517 aa overlap (1-517:1-480) 10 20 30 40 50 60 pF1KB8 MDFRTACEETKTGICLLQDGNQEPFKVRLHLAKDILMIQEQDVICVSGEPFYSGERTVTI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MDFRTACEETKTGICLLQDGNQEPFKVRLHLAKDILMIQEQDVICVSGEPFYSGERTVTI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 RRQTVGGFGLSIKGGAEHNIPVVVSKISKEQRAELSGLLFIGDAILQINGINVRKCRHEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RRQTVGGFGLSIKGGAEHNIPVVVSKISKEQRAELSGLLFIGDAILQINGINVRKCRHEE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 VVQVLRNAGEEVTLTVSFLKRAPAFLKLPLNEDCACAPSDQSSGTSSPLCDSGLHLNYHP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VVQVLRNAGEEVTLTVSFLKRAPAFLKLPLNEDCACAPSDQSSGTSSPLCDSGLHLNYHP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 NNTDTLSCSSWPTSPGLRWEKRWCDLRLIPLLHSRFSQYVPGTDLSRQNAFQVIAVDGVC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NNTDTLSCSSWPTSPGLRWEKRWCDLRLIPLLHSRFSQYVPGTDLSRQNAFQVIAVDGVC 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 TGIIQCLSAEDCVDWLQAIATNISNLTKHNIKKINRNFPVNQQIVYMGWCEAREQDPLQD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TGIIQCLSAEDCVDWLQAIATNISNLTKHNIKKINRNFPVNQQIVYMGWCEAREQDPLQD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 RVYSPTFLALRGSCLYKFLAPPVTTWDWTRAEKTFSVYEIMCKILKDSDLLDRRKQCFTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RVYSPTFLALRGSCLYKFLAPPVTTWDWTRAEKTFSVYEIMCKILKDSDLLDRRKQCFTV 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 QSESGEDLYFSVELESDLAQWERAFQTATFLEVERIQCKTYACVLESHLMGLTIDFSTGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QSESGEDLYFSVELESDLAQWERAFQTATFLEVERIQCKTYACVLESHLMGLTIDFSTGF 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB8 ICFDAATKAVLWRYKFSQLKGSSDDGKSKIKFLFQNPDTKQIEAKELEFSNLFAVLHCIH :::::::: ::::::::::::::: NP_001 ICFDAATK-------------------------------------ELEFSNLFAVLHCIH 430 440 490 500 510 pF1KB8 SFFAAKVACLDPLFLGNQATASTAASSATTSKAKYTT ::::::::::::::::::::::::::::::::::::: NP_001 SFFAAKVACLDPLFLGNQATASTAASSATTSKAKYTT 450 460 470 480 >>NP_001308706 (OMIM: 608714) gamma-1-syntrophin isoform (435 aa) initn: 2913 init1: 2913 opt: 2913 Z-score: 2336.8 bits: 441.7 E(85289): 2e-123 Smith-Waterman score: 2913; 99.5% identity (100.0% similar) in 430 aa overlap (1-430:1-430) 10 20 30 40 50 60 pF1KB8 MDFRTACEETKTGICLLQDGNQEPFKVRLHLAKDILMIQEQDVICVSGEPFYSGERTVTI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MDFRTACEETKTGICLLQDGNQEPFKVRLHLAKDILMIQEQDVICVSGEPFYSGERTVTI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 RRQTVGGFGLSIKGGAEHNIPVVVSKISKEQRAELSGLLFIGDAILQINGINVRKCRHEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RRQTVGGFGLSIKGGAEHNIPVVVSKISKEQRAELSGLLFIGDAILQINGINVRKCRHEE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 VVQVLRNAGEEVTLTVSFLKRAPAFLKLPLNEDCACAPSDQSSGTSSPLCDSGLHLNYHP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VVQVLRNAGEEVTLTVSFLKRAPAFLKLPLNEDCACAPSDQSSGTSSPLCDSGLHLNYHP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 NNTDTLSCSSWPTSPGLRWEKRWCDLRLIPLLHSRFSQYVPGTDLSRQNAFQVIAVDGVC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NNTDTLSCSSWPTSPGLRWEKRWCDLRLIPLLHSRFSQYVPGTDLSRQNAFQVIAVDGVC 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 TGIIQCLSAEDCVDWLQAIATNISNLTKHNIKKINRNFPVNQQIVYMGWCEAREQDPLQD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TGIIQCLSAEDCVDWLQAIATNISNLTKHNIKKINRNFPVNQQIVYMGWCEAREQDPLQD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 RVYSPTFLALRGSCLYKFLAPPVTTWDWTRAEKTFSVYEIMCKILKDSDLLDRRKQCFTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RVYSPTFLALRGSCLYKFLAPPVTTWDWTRAEKTFSVYEIMCKILKDSDLLDRRKQCFTV 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 QSESGEDLYFSVELESDLAQWERAFQTATFLEVERIQCKTYACVLESHLMGLTIDFSTGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QSESGEDLYFSVELESDLAQWERAFQTATFLEVERIQCKTYACVLESHLMGLTIDFSTGF 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB8 ICFDAATKAVLWRYKFSQLKGSSDDGKSKIKFLFQNPDTKQIEAKELEFSNLFAVLHCIH ::::::::.. NP_001 ICFDAATKVMCSGQL 430 >>NP_001308705 (OMIM: 608714) gamma-1-syntrophin isoform (435 aa) initn: 2913 init1: 2913 opt: 2913 Z-score: 2336.8 bits: 441.7 E(85289): 2e-123 Smith-Waterman score: 2913; 99.5% identity (100.0% similar) in 430 aa overlap (1-430:1-430) 10 20 30 40 50 60 pF1KB8 MDFRTACEETKTGICLLQDGNQEPFKVRLHLAKDILMIQEQDVICVSGEPFYSGERTVTI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MDFRTACEETKTGICLLQDGNQEPFKVRLHLAKDILMIQEQDVICVSGEPFYSGERTVTI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 RRQTVGGFGLSIKGGAEHNIPVVVSKISKEQRAELSGLLFIGDAILQINGINVRKCRHEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RRQTVGGFGLSIKGGAEHNIPVVVSKISKEQRAELSGLLFIGDAILQINGINVRKCRHEE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 VVQVLRNAGEEVTLTVSFLKRAPAFLKLPLNEDCACAPSDQSSGTSSPLCDSGLHLNYHP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VVQVLRNAGEEVTLTVSFLKRAPAFLKLPLNEDCACAPSDQSSGTSSPLCDSGLHLNYHP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 NNTDTLSCSSWPTSPGLRWEKRWCDLRLIPLLHSRFSQYVPGTDLSRQNAFQVIAVDGVC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NNTDTLSCSSWPTSPGLRWEKRWCDLRLIPLLHSRFSQYVPGTDLSRQNAFQVIAVDGVC 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 TGIIQCLSAEDCVDWLQAIATNISNLTKHNIKKINRNFPVNQQIVYMGWCEAREQDPLQD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TGIIQCLSAEDCVDWLQAIATNISNLTKHNIKKINRNFPVNQQIVYMGWCEAREQDPLQD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 RVYSPTFLALRGSCLYKFLAPPVTTWDWTRAEKTFSVYEIMCKILKDSDLLDRRKQCFTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RVYSPTFLALRGSCLYKFLAPPVTTWDWTRAEKTFSVYEIMCKILKDSDLLDRRKQCFTV 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 QSESGEDLYFSVELESDLAQWERAFQTATFLEVERIQCKTYACVLESHLMGLTIDFSTGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QSESGEDLYFSVELESDLAQWERAFQTATFLEVERIQCKTYACVLESHLMGLTIDFSTGF 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB8 ICFDAATKAVLWRYKFSQLKGSSDDGKSKIKFLFQNPDTKQIEAKELEFSNLFAVLHCIH ::::::::.. NP_001 ICFDAATKVMCSGQL 430 >>NP_001308704 (OMIM: 608714) gamma-1-syntrophin isoform (435 aa) initn: 2913 init1: 2913 opt: 2913 Z-score: 2336.8 bits: 441.7 E(85289): 2e-123 Smith-Waterman score: 2913; 99.5% identity (100.0% similar) in 430 aa overlap (1-430:1-430) 10 20 30 40 50 60 pF1KB8 MDFRTACEETKTGICLLQDGNQEPFKVRLHLAKDILMIQEQDVICVSGEPFYSGERTVTI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MDFRTACEETKTGICLLQDGNQEPFKVRLHLAKDILMIQEQDVICVSGEPFYSGERTVTI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 RRQTVGGFGLSIKGGAEHNIPVVVSKISKEQRAELSGLLFIGDAILQINGINVRKCRHEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RRQTVGGFGLSIKGGAEHNIPVVVSKISKEQRAELSGLLFIGDAILQINGINVRKCRHEE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 VVQVLRNAGEEVTLTVSFLKRAPAFLKLPLNEDCACAPSDQSSGTSSPLCDSGLHLNYHP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VVQVLRNAGEEVTLTVSFLKRAPAFLKLPLNEDCACAPSDQSSGTSSPLCDSGLHLNYHP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 NNTDTLSCSSWPTSPGLRWEKRWCDLRLIPLLHSRFSQYVPGTDLSRQNAFQVIAVDGVC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NNTDTLSCSSWPTSPGLRWEKRWCDLRLIPLLHSRFSQYVPGTDLSRQNAFQVIAVDGVC 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 TGIIQCLSAEDCVDWLQAIATNISNLTKHNIKKINRNFPVNQQIVYMGWCEAREQDPLQD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TGIIQCLSAEDCVDWLQAIATNISNLTKHNIKKINRNFPVNQQIVYMGWCEAREQDPLQD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 RVYSPTFLALRGSCLYKFLAPPVTTWDWTRAEKTFSVYEIMCKILKDSDLLDRRKQCFTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RVYSPTFLALRGSCLYKFLAPPVTTWDWTRAEKTFSVYEIMCKILKDSDLLDRRKQCFTV 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 QSESGEDLYFSVELESDLAQWERAFQTATFLEVERIQCKTYACVLESHLMGLTIDFSTGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QSESGEDLYFSVELESDLAQWERAFQTATFLEVERIQCKTYACVLESHLMGLTIDFSTGF 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB8 ICFDAATKAVLWRYKFSQLKGSSDDGKSKIKFLFQNPDTKQIEAKELEFSNLFAVLHCIH ::::::::.. NP_001 ICFDAATKVMCSGQL 430 517 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 09:44:35 2016 done: Fri Nov 4 09:44:36 2016 Total Scan time: 7.790 Total Display time: 0.080 Function used was FASTA [36.3.4 Apr, 2011]