FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8131, 183 aa 1>>>pF1KB8131 183 - 183 aa - 183 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.0553+/-0.000396; mu= 20.5442+/- 0.025 mean_var=78.6901+/-15.482, 0's: 0 Z-trim(113.9): 432 B-trim: 673 in 2/50 Lambda= 0.144582 statistics sampled from 23016 (23519) to 23016 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.669), E-opt: 0.2 (0.276), width: 16 Scan time: 4.390 The best scores are: opt bits E(85289) NP_066361 (OMIM: 179540) ras-related protein Rap-2 ( 183) 1195 258.3 5e-69 NP_002877 (OMIM: 179541) ras-related protein Rap-2 ( 183) 1089 236.2 2.3e-62 NP_001278825 (OMIM: 179520) ras-related protein Ra ( 184) 750 165.5 4.4e-41 XP_016857451 (OMIM: 179520) PREDICTED: ras-related ( 184) 750 165.5 4.4e-41 NP_002875 (OMIM: 179520) ras-related protein Rap-1 ( 184) 750 165.5 4.4e-41 NP_001010935 (OMIM: 179520) ras-related protein Ra ( 184) 750 165.5 4.4e-41 XP_016857453 (OMIM: 179520) PREDICTED: ras-related ( 184) 750 165.5 4.4e-41 XP_016857452 (OMIM: 179520) PREDICTED: ras-related ( 184) 750 165.5 4.4e-41 NP_001010942 (OMIM: 179530) ras-related protein Ra ( 184) 731 161.5 6.9e-40 NP_056461 (OMIM: 179530) ras-related protein Rap-1 ( 184) 731 161.5 6.9e-40 XP_016857450 (OMIM: 179520) PREDICTED: ras-related ( 195) 693 153.6 1.7e-37 XP_016857449 (OMIM: 179520) PREDICTED: ras-related ( 195) 693 153.6 1.7e-37 NP_005334 (OMIM: 109800,137550,162900,163200,18847 ( 189) 584 130.9 1.2e-30 NP_001123914 (OMIM: 109800,137550,162900,163200,18 ( 189) 584 130.9 1.2e-30 NP_008843 (OMIM: 609591,615355) GTP-binding protei ( 219) 581 130.3 2e-30 NP_001243750 (OMIM: 609591,615355) GTP-binding pro ( 236) 581 130.4 2.1e-30 NP_004976 (OMIM: 109800,114480,137215,163200,19007 ( 188) 577 129.4 3.3e-30 XP_011518955 (OMIM: 109800,114480,137215,163200,19 ( 188) 577 129.4 3.3e-30 XP_006719132 (OMIM: 109800,114480,137215,163200,19 ( 189) 571 128.2 7.8e-30 NP_203524 (OMIM: 109800,114480,137215,163200,19007 ( 189) 571 128.2 7.8e-30 XP_016874782 (OMIM: 109800,114480,137215,163200,19 ( 227) 571 128.3 8.7e-30 NP_002921 (OMIM: 609592) GTP-binding protein Rit2 ( 217) 566 127.2 1.7e-29 NP_002515 (OMIM: 114500,137550,162900,163200,16479 ( 189) 560 125.9 3.8e-29 XP_016860111 (OMIM: 179551) PREDICTED: ras-related ( 206) 537 121.1 1.1e-27 XP_005263785 (OMIM: 179551) PREDICTED: ras-related ( 206) 537 121.1 1.1e-27 XP_005263784 (OMIM: 179551) PREDICTED: ras-related ( 206) 537 121.1 1.1e-27 XP_005263786 (OMIM: 179551) PREDICTED: ras-related ( 206) 537 121.1 1.1e-27 NP_002872 (OMIM: 179551) ras-related protein Ral-B ( 206) 537 121.1 1.1e-27 XP_016860110 (OMIM: 179551) PREDICTED: ras-related ( 228) 537 121.2 1.2e-27 XP_005263781 (OMIM: 179551) PREDICTED: ras-related ( 228) 537 121.2 1.2e-27 XP_011509875 (OMIM: 179551) PREDICTED: ras-related ( 229) 537 121.2 1.2e-27 NP_789765 (OMIM: 109800,137550,162900,163200,18847 ( 170) 534 120.4 1.5e-27 NP_036382 (OMIM: 600098) ras-related protein R-Ras ( 204) 534 120.5 1.7e-27 NP_060064 (OMIM: 607863) GTP-binding protein Di-Ra ( 199) 529 119.4 3.5e-27 XP_006715825 (OMIM: 179550) PREDICTED: ras-related ( 206) 527 119.0 4.7e-27 NP_005393 (OMIM: 179550) ras-related protein Ral-A ( 206) 527 119.0 4.7e-27 XP_011513768 (OMIM: 179550) PREDICTED: ras-related ( 206) 527 119.0 4.7e-27 NP_006261 (OMIM: 165090) ras-related protein R-Ras ( 218) 526 118.9 5.7e-27 NP_660156 (OMIM: 607862) GTP-binding protein Di-Ra ( 198) 516 116.7 2.3e-26 XP_011526015 (OMIM: 607862) PREDICTED: GTP-binding ( 232) 516 116.8 2.5e-26 NP_036351 (OMIM: 608435) ras-related protein M-Ras ( 208) 510 115.5 5.6e-26 NP_001239019 (OMIM: 608435) ras-related protein M- ( 208) 510 115.5 5.6e-26 XP_005247285 (OMIM: 608435) PREDICTED: ras-related ( 208) 510 115.5 5.6e-26 NP_001078518 (OMIM: 608435) ras-related protein M- ( 208) 510 115.5 5.6e-26 XP_016861376 (OMIM: 608435) PREDICTED: ras-related ( 208) 510 115.5 5.6e-26 NP_001243749 (OMIM: 609591,615355) GTP-binding pro ( 183) 488 110.8 1.2e-24 NP_001259006 (OMIM: 609592) GTP-binding protein Ri ( 153) 460 104.9 6.4e-23 XP_005247286 (OMIM: 608435) PREDICTED: ras-related ( 170) 448 102.4 3.9e-22 NP_116307 (OMIM: 612664) ras-related and estrogen- ( 199) 439 100.7 1.6e-21 XP_011509876 (OMIM: 179551) PREDICTED: ras-related ( 195) 437 100.2 2.1e-21 >>NP_066361 (OMIM: 179540) ras-related protein Rap-2a pr (183 aa) initn: 1195 init1: 1195 opt: 1195 Z-score: 1360.2 bits: 258.3 E(85289): 5e-69 Smith-Waterman score: 1195; 100.0% identity (100.0% similar) in 183 aa overlap (1-183:1-183) 10 20 30 40 50 60 pF1KB8 MREYKVVVLGSGGVGKSALTVQFVTGTFIEKYDPTIEDFYRKEIEVDSSPSVLEILDTAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_066 MREYKVVVLGSGGVGKSALTVQFVTGTFIEKYDPTIEDFYRKEIEVDSSPSVLEILDTAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 TEQFASMRDLYIKNGQGFILVYSLVNQQSFQDIKPMRDQIIRVKRYEKVPVILVGNKVDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_066 TEQFASMRDLYIKNGQGFILVYSLVNQQSFQDIKPMRDQIIRVKRYEKVPVILVGNKVDL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 ESEREVSSSEGRALAEEWGCPFMETSAKSKTMVDELFAEIVRQMNYAAQPDKDDPCCSAC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_066 ESEREVSSSEGRALAEEWGCPFMETSAKSKTMVDELFAEIVRQMNYAAQPDKDDPCCSAC 130 140 150 160 170 180 pF1KB8 NIQ ::: NP_066 NIQ >>NP_002877 (OMIM: 179541) ras-related protein Rap-2b [H (183 aa) initn: 1106 init1: 1089 opt: 1089 Z-score: 1240.7 bits: 236.2 E(85289): 2.3e-62 Smith-Waterman score: 1089; 91.2% identity (97.3% similar) in 182 aa overlap (1-182:1-182) 10 20 30 40 50 60 pF1KB8 MREYKVVVLGSGGVGKSALTVQFVTGTFIEKYDPTIEDFYRKEIEVDSSPSVLEILDTAG ::::::::::::::::::::::::::.::::::::::::::::::::::::::::::::: NP_002 MREYKVVVLGSGGVGKSALTVQFVTGSFIEKYDPTIEDFYRKEIEVDSSPSVLEILDTAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 TEQFASMRDLYIKNGQGFILVYSLVNQQSFQDIKPMRDQIIRVKRYEKVPVILVGNKVDL :::::::::::::::::::::::::::::::::::::::::::::::.::.::::::::: NP_002 TEQFASMRDLYIKNGQGFILVYSLVNQQSFQDIKPMRDQIIRVKRYERVPMILVGNKVDL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 ESEREVSSSEGRALAEEWGCPFMETSAKSKTMVDELFAEIVRQMNYAAQPDKDDPCCSAC :.::::: .::.::::::.:::::::::.:. ::::::::::::::::::. :. ::::: NP_002 EGEREVSYGEGKALAEEWSCPFMETSAKNKASVDELFAEIVRQMNYAAQPNGDEGCCSAC 130 140 150 160 170 180 pF1KB8 NIQ : NP_002 VIL >>NP_001278825 (OMIM: 179520) ras-related protein Rap-1A (184 aa) initn: 699 init1: 636 opt: 750 Z-score: 858.5 bits: 165.5 E(85289): 4.4e-41 Smith-Waterman score: 750; 62.4% identity (84.0% similar) in 181 aa overlap (1-180:1-181) 10 20 30 40 50 60 pF1KB8 MREYKVVVLGSGGVGKSALTVQFVTGTFIEKYDPTIEDFYRKEIEVDSSPSVLEILDTAG :::::.:::::::::::::::::: : :.::::::::: :::..::: . .:::::::: NP_001 MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDCQQCMLEILDTAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 TEQFASMRDLYIKNGQGFILVYSLVNQQSFQDIKPMRDQIIRVKRYEKVPVILVGNKVDL ::::..:::::.:::::: ::::.. :..:.:.. .:.::.::: : ::.:::::: :: NP_001 TEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTEDVPMILVGNKCDL 70 80 90 100 110 120 130 140 150 160 170 pF1KB8 ESEREVSSSEGRALAEEW-GCPFMETSAKSKTMVDELFAEIVRQMNYAAQPDKDDPCCSA :.:: :.. .:. ::..: .: :.:.::::: :.:.: ..:::.: . .: : .. NP_001 EDERVVGKEQGQNLARQWCNCAFLESSAKSKINVNEIFYDLVRQINRKTPVEKKKPKKKS 130 140 150 160 170 180 180 pF1KB8 CNIQ : NP_001 CLLL >>XP_016857451 (OMIM: 179520) PREDICTED: ras-related pro (184 aa) initn: 699 init1: 636 opt: 750 Z-score: 858.5 bits: 165.5 E(85289): 4.4e-41 Smith-Waterman score: 750; 62.4% identity (84.0% similar) in 181 aa overlap (1-180:1-181) 10 20 30 40 50 60 pF1KB8 MREYKVVVLGSGGVGKSALTVQFVTGTFIEKYDPTIEDFYRKEIEVDSSPSVLEILDTAG :::::.:::::::::::::::::: : :.::::::::: :::..::: . .:::::::: XP_016 MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDCQQCMLEILDTAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 TEQFASMRDLYIKNGQGFILVYSLVNQQSFQDIKPMRDQIIRVKRYEKVPVILVGNKVDL ::::..:::::.:::::: ::::.. :..:.:.. .:.::.::: : ::.:::::: :: XP_016 TEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTEDVPMILVGNKCDL 70 80 90 100 110 120 130 140 150 160 170 pF1KB8 ESEREVSSSEGRALAEEW-GCPFMETSAKSKTMVDELFAEIVRQMNYAAQPDKDDPCCSA :.:: :.. .:. ::..: .: :.:.::::: :.:.: ..:::.: . .: : .. XP_016 EDERVVGKEQGQNLARQWCNCAFLESSAKSKINVNEIFYDLVRQINRKTPVEKKKPKKKS 130 140 150 160 170 180 180 pF1KB8 CNIQ : XP_016 CLLL >>NP_002875 (OMIM: 179520) ras-related protein Rap-1A pr (184 aa) initn: 699 init1: 636 opt: 750 Z-score: 858.5 bits: 165.5 E(85289): 4.4e-41 Smith-Waterman score: 750; 62.4% identity (84.0% similar) in 181 aa overlap (1-180:1-181) 10 20 30 40 50 60 pF1KB8 MREYKVVVLGSGGVGKSALTVQFVTGTFIEKYDPTIEDFYRKEIEVDSSPSVLEILDTAG :::::.:::::::::::::::::: : :.::::::::: :::..::: . .:::::::: NP_002 MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDCQQCMLEILDTAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 TEQFASMRDLYIKNGQGFILVYSLVNQQSFQDIKPMRDQIIRVKRYEKVPVILVGNKVDL ::::..:::::.:::::: ::::.. :..:.:.. .:.::.::: : ::.:::::: :: NP_002 TEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTEDVPMILVGNKCDL 70 80 90 100 110 120 130 140 150 160 170 pF1KB8 ESEREVSSSEGRALAEEW-GCPFMETSAKSKTMVDELFAEIVRQMNYAAQPDKDDPCCSA :.:: :.. .:. ::..: .: :.:.::::: :.:.: ..:::.: . .: : .. NP_002 EDERVVGKEQGQNLARQWCNCAFLESSAKSKINVNEIFYDLVRQINRKTPVEKKKPKKKS 130 140 150 160 170 180 180 pF1KB8 CNIQ : NP_002 CLLL >>NP_001010935 (OMIM: 179520) ras-related protein Rap-1A (184 aa) initn: 699 init1: 636 opt: 750 Z-score: 858.5 bits: 165.5 E(85289): 4.4e-41 Smith-Waterman score: 750; 62.4% identity (84.0% similar) in 181 aa overlap (1-180:1-181) 10 20 30 40 50 60 pF1KB8 MREYKVVVLGSGGVGKSALTVQFVTGTFIEKYDPTIEDFYRKEIEVDSSPSVLEILDTAG :::::.:::::::::::::::::: : :.::::::::: :::..::: . .:::::::: NP_001 MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDCQQCMLEILDTAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 TEQFASMRDLYIKNGQGFILVYSLVNQQSFQDIKPMRDQIIRVKRYEKVPVILVGNKVDL ::::..:::::.:::::: ::::.. :..:.:.. .:.::.::: : ::.:::::: :: NP_001 TEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTEDVPMILVGNKCDL 70 80 90 100 110 120 130 140 150 160 170 pF1KB8 ESEREVSSSEGRALAEEW-GCPFMETSAKSKTMVDELFAEIVRQMNYAAQPDKDDPCCSA :.:: :.. .:. ::..: .: :.:.::::: :.:.: ..:::.: . .: : .. NP_001 EDERVVGKEQGQNLARQWCNCAFLESSAKSKINVNEIFYDLVRQINRKTPVEKKKPKKKS 130 140 150 160 170 180 180 pF1KB8 CNIQ : NP_001 CLLL >>XP_016857453 (OMIM: 179520) PREDICTED: ras-related pro (184 aa) initn: 699 init1: 636 opt: 750 Z-score: 858.5 bits: 165.5 E(85289): 4.4e-41 Smith-Waterman score: 750; 62.4% identity (84.0% similar) in 181 aa overlap (1-180:1-181) 10 20 30 40 50 60 pF1KB8 MREYKVVVLGSGGVGKSALTVQFVTGTFIEKYDPTIEDFYRKEIEVDSSPSVLEILDTAG :::::.:::::::::::::::::: : :.::::::::: :::..::: . .:::::::: XP_016 MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDCQQCMLEILDTAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 TEQFASMRDLYIKNGQGFILVYSLVNQQSFQDIKPMRDQIIRVKRYEKVPVILVGNKVDL ::::..:::::.:::::: ::::.. :..:.:.. .:.::.::: : ::.:::::: :: XP_016 TEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTEDVPMILVGNKCDL 70 80 90 100 110 120 130 140 150 160 170 pF1KB8 ESEREVSSSEGRALAEEW-GCPFMETSAKSKTMVDELFAEIVRQMNYAAQPDKDDPCCSA :.:: :.. .:. ::..: .: :.:.::::: :.:.: ..:::.: . .: : .. XP_016 EDERVVGKEQGQNLARQWCNCAFLESSAKSKINVNEIFYDLVRQINRKTPVEKKKPKKKS 130 140 150 160 170 180 180 pF1KB8 CNIQ : XP_016 CLLL >>XP_016857452 (OMIM: 179520) PREDICTED: ras-related pro (184 aa) initn: 699 init1: 636 opt: 750 Z-score: 858.5 bits: 165.5 E(85289): 4.4e-41 Smith-Waterman score: 750; 62.4% identity (84.0% similar) in 181 aa overlap (1-180:1-181) 10 20 30 40 50 60 pF1KB8 MREYKVVVLGSGGVGKSALTVQFVTGTFIEKYDPTIEDFYRKEIEVDSSPSVLEILDTAG :::::.:::::::::::::::::: : :.::::::::: :::..::: . .:::::::: XP_016 MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDCQQCMLEILDTAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 TEQFASMRDLYIKNGQGFILVYSLVNQQSFQDIKPMRDQIIRVKRYEKVPVILVGNKVDL ::::..:::::.:::::: ::::.. :..:.:.. .:.::.::: : ::.:::::: :: XP_016 TEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTEDVPMILVGNKCDL 70 80 90 100 110 120 130 140 150 160 170 pF1KB8 ESEREVSSSEGRALAEEW-GCPFMETSAKSKTMVDELFAEIVRQMNYAAQPDKDDPCCSA :.:: :.. .:. ::..: .: :.:.::::: :.:.: ..:::.: . .: : .. XP_016 EDERVVGKEQGQNLARQWCNCAFLESSAKSKINVNEIFYDLVRQINRKTPVEKKKPKKKS 130 140 150 160 170 180 180 pF1KB8 CNIQ : XP_016 CLLL >>NP_001010942 (OMIM: 179530) ras-related protein Rap-1b (184 aa) initn: 697 init1: 634 opt: 731 Z-score: 837.1 bits: 161.5 E(85289): 6.9e-40 Smith-Waterman score: 731; 61.4% identity (83.7% similar) in 184 aa overlap (1-182:1-183) 10 20 30 40 50 60 pF1KB8 MREYKVVVLGSGGVGKSALTVQFVTGTFIEKYDPTIEDFYRKEIEVDSSPSVLEILDTAG :::::.:::::::::::::::::: : :.::::::::: :::..:::.. .:::::::: NP_001 MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDAQQCMLEILDTAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 TEQFASMRDLYIKNGQGFILVYSLVNQQSFQDIKPMRDQIIRVKRYEKVPVILVGNKVDL ::::..:::::.:::::: ::::.. :..:.:.. .:.::.::: . ::.:::::: :: NP_001 TEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTDDVPMILVGNKCDL 70 80 90 100 110 120 130 140 150 160 170 pF1KB8 ESEREVSSSEGRALAEEWG-CPFMETSAKSKTMVDELFAEIVRQMNYAAQ-PDKDDPCCS :.:: :.. .:. ::..:. : :.:.::::: :.:.: ..:::.: . : : : NP_001 EDERVVGKEQGQNLARQWNNCAFLESSAKSKINVNEIFYDLVRQINRKTPVPGKARKK-S 130 140 150 160 170 180 pF1KB8 ACNIQ .:.. NP_001 SCQLL 180 >>NP_056461 (OMIM: 179530) ras-related protein Rap-1b is (184 aa) initn: 697 init1: 634 opt: 731 Z-score: 837.1 bits: 161.5 E(85289): 6.9e-40 Smith-Waterman score: 731; 61.4% identity (83.7% similar) in 184 aa overlap (1-182:1-183) 10 20 30 40 50 60 pF1KB8 MREYKVVVLGSGGVGKSALTVQFVTGTFIEKYDPTIEDFYRKEIEVDSSPSVLEILDTAG :::::.:::::::::::::::::: : :.::::::::: :::..:::.. .:::::::: NP_056 MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDAQQCMLEILDTAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 TEQFASMRDLYIKNGQGFILVYSLVNQQSFQDIKPMRDQIIRVKRYEKVPVILVGNKVDL ::::..:::::.:::::: ::::.. :..:.:.. .:.::.::: . ::.:::::: :: NP_056 TEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTDDVPMILVGNKCDL 70 80 90 100 110 120 130 140 150 160 170 pF1KB8 ESEREVSSSEGRALAEEWG-CPFMETSAKSKTMVDELFAEIVRQMNYAAQ-PDKDDPCCS :.:: :.. .:. ::..:. : :.:.::::: :.:.: ..:::.: . : : : NP_056 EDERVVGKEQGQNLARQWNNCAFLESSAKSKINVNEIFYDLVRQINRKTPVPGKARKK-S 130 140 150 160 170 180 pF1KB8 ACNIQ .:.. NP_056 SCQLL 180 183 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 09:49:47 2016 done: Fri Nov 4 09:49:47 2016 Total Scan time: 4.390 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]