FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8142, 394 aa 1>>>pF1KB8142 394 - 394 aa - 394 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.0740+/-0.000346; mu= 19.7052+/- 0.022 mean_var=83.5295+/-17.161, 0's: 0 Z-trim(115.7): 75 B-trim: 12 in 1/52 Lambda= 0.140331 statistics sampled from 26187 (26263) to 26187 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.687), E-opt: 0.2 (0.308), width: 16 Scan time: 8.090 The best scores are: opt bits E(85289) XP_011526595 (OMIM: 615334) PREDICTED: ceramide sy ( 394) 2698 555.9 6.1e-158 XP_011526592 (OMIM: 615334) PREDICTED: ceramide sy ( 394) 2698 555.9 6.1e-158 XP_011526596 (OMIM: 615334) PREDICTED: ceramide sy ( 394) 2698 555.9 6.1e-158 XP_011526594 (OMIM: 615334) PREDICTED: ceramide sy ( 394) 2698 555.9 6.1e-158 NP_078828 (OMIM: 615334) ceramide synthase 4 [Homo ( 394) 2698 555.9 6.1e-158 XP_016882794 (OMIM: 615334) PREDICTED: ceramide sy ( 394) 2698 555.9 6.1e-158 XP_011526593 (OMIM: 615334) PREDICTED: ceramide sy ( 394) 2698 555.9 6.1e-158 XP_016882793 (OMIM: 615334) PREDICTED: ceramide sy ( 394) 2698 555.9 6.1e-158 XP_016882792 (OMIM: 615334) PREDICTED: ceramide sy ( 394) 2698 555.9 6.1e-158 XP_011526597 (OMIM: 615334) PREDICTED: ceramide sy ( 394) 2698 555.9 6.1e-158 NP_071358 (OMIM: 606920) ceramide synthase 2 [Homo ( 380) 1288 270.4 5.1e-72 NP_859530 (OMIM: 606920) ceramide synthase 2 [Homo ( 380) 1288 270.4 5.1e-72 XP_011507754 (OMIM: 606920) PREDICTED: ceramide sy ( 380) 1288 270.4 5.1e-72 XP_011507753 (OMIM: 606920) PREDICTED: ceramide sy ( 400) 1288 270.4 5.3e-72 NP_001277271 (OMIM: 615023,615276) ceramide syntha ( 383) 1174 247.3 4.6e-65 NP_001277272 (OMIM: 615023,615276) ceramide syntha ( 383) 1174 247.3 4.6e-65 NP_849164 (OMIM: 615023,615276) ceramide synthase ( 383) 1174 247.3 4.6e-65 XP_016877493 (OMIM: 615023,615276) PREDICTED: cera ( 383) 1174 247.3 4.6e-65 XP_016877492 (OMIM: 615023,615276) PREDICTED: cera ( 383) 1174 247.3 4.6e-65 NP_001277270 (OMIM: 615023,615276) ceramide syntha ( 394) 1174 247.3 4.7e-65 XP_011519660 (OMIM: 615023,615276) PREDICTED: cera ( 394) 1174 247.3 4.7e-65 XP_011519657 (OMIM: 615023,615276) PREDICTED: cera ( 394) 1174 247.3 4.7e-65 XP_011519659 (OMIM: 615023,615276) PREDICTED: cera ( 394) 1174 247.3 4.7e-65 XP_016877491 (OMIM: 615023,615276) PREDICTED: cera ( 394) 1174 247.3 4.7e-65 NP_671723 (OMIM: 615335) ceramide synthase 5 isofo ( 392) 1108 234.0 4.9e-61 NP_982288 (OMIM: 615336) ceramide synthase 6 isofo ( 384) 1081 228.5 2.1e-59 NP_001317999 (OMIM: 615335) ceramide synthase 5 is ( 392) 1073 226.9 6.6e-59 XP_005269277 (OMIM: 615335) PREDICTED: ceramide sy ( 409) 1065 225.3 2.1e-58 NP_001243055 (OMIM: 615336) ceramide synthase 6 is ( 392) 1055 223.2 8.3e-58 NP_001318000 (OMIM: 615335) ceramide synthase 5 is ( 381) 1052 222.6 1.2e-57 NP_001268660 (OMIM: 615335) ceramide synthase 5 is ( 334) 929 197.7 3.5e-50 XP_016875693 (OMIM: 615335) PREDICTED: ceramide sy ( 290) 909 193.6 5.3e-49 XP_016875691 (OMIM: 615335) PREDICTED: ceramide sy ( 334) 894 190.6 4.8e-48 NP_001317998 (OMIM: 615335) ceramide synthase 5 is ( 323) 873 186.3 8.9e-47 NP_001318001 (OMIM: 615335) ceramide synthase 5 is ( 248) 716 154.4 2.7e-37 NP_001318002 (OMIM: 615335) ceramide synthase 5 is ( 237) 660 143.1 6.9e-34 XP_016875694 (OMIM: 615335) PREDICTED: ceramide sy ( 237) 660 143.1 6.9e-34 XP_016859238 (OMIM: 615336) PREDICTED: ceramide sy ( 251) 611 133.2 6.9e-31 XP_005246497 (OMIM: 615336) PREDICTED: ceramide sy ( 200) 475 105.5 1.1e-22 NP_067090 (OMIM: 606919,616230) ceramide synthase ( 350) 268 63.9 7e-10 NP_937850 (OMIM: 606919,616230) ceramide synthase ( 337) 263 62.8 1.4e-09 NP_001277194 (OMIM: 606919,616230) ceramide syntha ( 239) 243 58.6 1.8e-08 XP_011513307 (OMIM: 608485) PREDICTED: translocati ( 333) 206 51.3 4.1e-06 NP_036420 (OMIM: 608485) translocating chain-assoc ( 370) 206 51.3 4.4e-06 XP_016868755 (OMIM: 605190) PREDICTED: translocati ( 278) 188 47.6 4.5e-05 XP_016868756 (OMIM: 605190) PREDICTED: translocati ( 278) 188 47.6 4.5e-05 NP_001304734 (OMIM: 605190) translocating chain-as ( 288) 184 46.8 8.1e-05 NP_001304733 (OMIM: 605190) translocating chain-as ( 343) 184 46.8 9.1e-05 NP_055109 (OMIM: 605190) translocating chain-assoc ( 374) 184 46.9 9.7e-05 >>XP_011526595 (OMIM: 615334) PREDICTED: ceramide syntha (394 aa) initn: 2698 init1: 2698 opt: 2698 Z-score: 2956.5 bits: 555.9 E(85289): 6.1e-158 Smith-Waterman score: 2698; 99.2% identity (99.7% similar) in 394 aa overlap (1-394:1-394) 10 20 30 40 50 60 pF1KB8 MLSSFNEWFWQDRFWLPPNVTWTELEDRDGRVYPHPQDLLAALPLALVLLAMRLAFERFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MLSSFNEWFWQDRFWLPPNVTWTELEDRDGRVYPHPQDLLAALPLALVLLAMRLAFERFI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 GLPLSRWLGVRDQTRRQVKPNATLEKHFLTEGHRPKEPQLSLLAAQCGLTLQQTQRWFRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GLPLSRWLGVRDQTRRQVKPNATLEKHFLTEGHRPKEPQLSLLAAQCGLTLQQTQRWFRR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 RRNQDRPQLTKKFCEASWRFLFYLSSFVGGLSVLYHESWLWAPVMCWDRYPNQTLKPSLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RRNQDRPQLTKKFCEASWRFLFYLSSFVGGLSVLYHESWLWAPVMCWDRYPNQTLKPSLY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 WWYLLELGFYLSLLIRLPFDVKRKDFKEQVIHHFVAVILMTFSYSANLLRIGSLVLLLHD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 WWYLLELGFYLSLLIRLPFDVKRKDFKEQVIHHFVAVILMTFSYSANLLRIGSLVLLLHD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 SSDYLLEACKMVNYMQYQQVCDALFLIFSFVFFYTRLVLFPTQILYTIYYESISNRGPFF ::::::::::::::::::::::::::::::::::::::::::::::: :::::::::::: XP_011 SSDYLLEACKMVNYMQYQQVCDALFLIFSFVFFYTRLVLFPTQILYTTYYESISNRGPFF 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 GYYFFNGLLMLLQLLHVFWSCLILRMLYSFMKKGQMEKDIRSDVEESDSSEEVAAAQEPL ::::::::::::::::::::::::::::::::::::::::::::::::::::.::::::: XP_011 GYYFFNGLLMLLQLLHVFWSCLILRMLYSFMKKGQMEKDIRSDVEESDSSEEAAAAQEPL 310 320 330 340 350 360 370 380 390 pF1KB8 QLKNGAAGGPRPAPTDGPQSRVAGRLTNRHTTAT ::::::::::::::::::.::::::::::::::: XP_011 QLKNGAAGGPRPAPTDGPRSRVAGRLTNRHTTAT 370 380 390 >>XP_011526592 (OMIM: 615334) PREDICTED: ceramide syntha (394 aa) initn: 2698 init1: 2698 opt: 2698 Z-score: 2956.5 bits: 555.9 E(85289): 6.1e-158 Smith-Waterman score: 2698; 99.2% identity (99.7% similar) in 394 aa overlap (1-394:1-394) 10 20 30 40 50 60 pF1KB8 MLSSFNEWFWQDRFWLPPNVTWTELEDRDGRVYPHPQDLLAALPLALVLLAMRLAFERFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MLSSFNEWFWQDRFWLPPNVTWTELEDRDGRVYPHPQDLLAALPLALVLLAMRLAFERFI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 GLPLSRWLGVRDQTRRQVKPNATLEKHFLTEGHRPKEPQLSLLAAQCGLTLQQTQRWFRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GLPLSRWLGVRDQTRRQVKPNATLEKHFLTEGHRPKEPQLSLLAAQCGLTLQQTQRWFRR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 RRNQDRPQLTKKFCEASWRFLFYLSSFVGGLSVLYHESWLWAPVMCWDRYPNQTLKPSLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RRNQDRPQLTKKFCEASWRFLFYLSSFVGGLSVLYHESWLWAPVMCWDRYPNQTLKPSLY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 WWYLLELGFYLSLLIRLPFDVKRKDFKEQVIHHFVAVILMTFSYSANLLRIGSLVLLLHD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 WWYLLELGFYLSLLIRLPFDVKRKDFKEQVIHHFVAVILMTFSYSANLLRIGSLVLLLHD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 SSDYLLEACKMVNYMQYQQVCDALFLIFSFVFFYTRLVLFPTQILYTIYYESISNRGPFF ::::::::::::::::::::::::::::::::::::::::::::::: :::::::::::: XP_011 SSDYLLEACKMVNYMQYQQVCDALFLIFSFVFFYTRLVLFPTQILYTTYYESISNRGPFF 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 GYYFFNGLLMLLQLLHVFWSCLILRMLYSFMKKGQMEKDIRSDVEESDSSEEVAAAQEPL ::::::::::::::::::::::::::::::::::::::::::::::::::::.::::::: XP_011 GYYFFNGLLMLLQLLHVFWSCLILRMLYSFMKKGQMEKDIRSDVEESDSSEEAAAAQEPL 310 320 330 340 350 360 370 380 390 pF1KB8 QLKNGAAGGPRPAPTDGPQSRVAGRLTNRHTTAT ::::::::::::::::::.::::::::::::::: XP_011 QLKNGAAGGPRPAPTDGPRSRVAGRLTNRHTTAT 370 380 390 >>XP_011526596 (OMIM: 615334) PREDICTED: ceramide syntha (394 aa) initn: 2698 init1: 2698 opt: 2698 Z-score: 2956.5 bits: 555.9 E(85289): 6.1e-158 Smith-Waterman score: 2698; 99.2% identity (99.7% similar) in 394 aa overlap (1-394:1-394) 10 20 30 40 50 60 pF1KB8 MLSSFNEWFWQDRFWLPPNVTWTELEDRDGRVYPHPQDLLAALPLALVLLAMRLAFERFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MLSSFNEWFWQDRFWLPPNVTWTELEDRDGRVYPHPQDLLAALPLALVLLAMRLAFERFI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 GLPLSRWLGVRDQTRRQVKPNATLEKHFLTEGHRPKEPQLSLLAAQCGLTLQQTQRWFRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GLPLSRWLGVRDQTRRQVKPNATLEKHFLTEGHRPKEPQLSLLAAQCGLTLQQTQRWFRR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 RRNQDRPQLTKKFCEASWRFLFYLSSFVGGLSVLYHESWLWAPVMCWDRYPNQTLKPSLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RRNQDRPQLTKKFCEASWRFLFYLSSFVGGLSVLYHESWLWAPVMCWDRYPNQTLKPSLY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 WWYLLELGFYLSLLIRLPFDVKRKDFKEQVIHHFVAVILMTFSYSANLLRIGSLVLLLHD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 WWYLLELGFYLSLLIRLPFDVKRKDFKEQVIHHFVAVILMTFSYSANLLRIGSLVLLLHD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 SSDYLLEACKMVNYMQYQQVCDALFLIFSFVFFYTRLVLFPTQILYTIYYESISNRGPFF ::::::::::::::::::::::::::::::::::::::::::::::: :::::::::::: XP_011 SSDYLLEACKMVNYMQYQQVCDALFLIFSFVFFYTRLVLFPTQILYTTYYESISNRGPFF 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 GYYFFNGLLMLLQLLHVFWSCLILRMLYSFMKKGQMEKDIRSDVEESDSSEEVAAAQEPL ::::::::::::::::::::::::::::::::::::::::::::::::::::.::::::: XP_011 GYYFFNGLLMLLQLLHVFWSCLILRMLYSFMKKGQMEKDIRSDVEESDSSEEAAAAQEPL 310 320 330 340 350 360 370 380 390 pF1KB8 QLKNGAAGGPRPAPTDGPQSRVAGRLTNRHTTAT ::::::::::::::::::.::::::::::::::: XP_011 QLKNGAAGGPRPAPTDGPRSRVAGRLTNRHTTAT 370 380 390 >>XP_011526594 (OMIM: 615334) PREDICTED: ceramide syntha (394 aa) initn: 2698 init1: 2698 opt: 2698 Z-score: 2956.5 bits: 555.9 E(85289): 6.1e-158 Smith-Waterman score: 2698; 99.2% identity (99.7% similar) in 394 aa overlap (1-394:1-394) 10 20 30 40 50 60 pF1KB8 MLSSFNEWFWQDRFWLPPNVTWTELEDRDGRVYPHPQDLLAALPLALVLLAMRLAFERFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MLSSFNEWFWQDRFWLPPNVTWTELEDRDGRVYPHPQDLLAALPLALVLLAMRLAFERFI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 GLPLSRWLGVRDQTRRQVKPNATLEKHFLTEGHRPKEPQLSLLAAQCGLTLQQTQRWFRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GLPLSRWLGVRDQTRRQVKPNATLEKHFLTEGHRPKEPQLSLLAAQCGLTLQQTQRWFRR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 RRNQDRPQLTKKFCEASWRFLFYLSSFVGGLSVLYHESWLWAPVMCWDRYPNQTLKPSLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RRNQDRPQLTKKFCEASWRFLFYLSSFVGGLSVLYHESWLWAPVMCWDRYPNQTLKPSLY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 WWYLLELGFYLSLLIRLPFDVKRKDFKEQVIHHFVAVILMTFSYSANLLRIGSLVLLLHD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 WWYLLELGFYLSLLIRLPFDVKRKDFKEQVIHHFVAVILMTFSYSANLLRIGSLVLLLHD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 SSDYLLEACKMVNYMQYQQVCDALFLIFSFVFFYTRLVLFPTQILYTIYYESISNRGPFF ::::::::::::::::::::::::::::::::::::::::::::::: :::::::::::: XP_011 SSDYLLEACKMVNYMQYQQVCDALFLIFSFVFFYTRLVLFPTQILYTTYYESISNRGPFF 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 GYYFFNGLLMLLQLLHVFWSCLILRMLYSFMKKGQMEKDIRSDVEESDSSEEVAAAQEPL ::::::::::::::::::::::::::::::::::::::::::::::::::::.::::::: XP_011 GYYFFNGLLMLLQLLHVFWSCLILRMLYSFMKKGQMEKDIRSDVEESDSSEEAAAAQEPL 310 320 330 340 350 360 370 380 390 pF1KB8 QLKNGAAGGPRPAPTDGPQSRVAGRLTNRHTTAT ::::::::::::::::::.::::::::::::::: XP_011 QLKNGAAGGPRPAPTDGPRSRVAGRLTNRHTTAT 370 380 390 >>NP_078828 (OMIM: 615334) ceramide synthase 4 [Homo sap (394 aa) initn: 2698 init1: 2698 opt: 2698 Z-score: 2956.5 bits: 555.9 E(85289): 6.1e-158 Smith-Waterman score: 2698; 99.2% identity (99.7% similar) in 394 aa overlap (1-394:1-394) 10 20 30 40 50 60 pF1KB8 MLSSFNEWFWQDRFWLPPNVTWTELEDRDGRVYPHPQDLLAALPLALVLLAMRLAFERFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_078 MLSSFNEWFWQDRFWLPPNVTWTELEDRDGRVYPHPQDLLAALPLALVLLAMRLAFERFI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 GLPLSRWLGVRDQTRRQVKPNATLEKHFLTEGHRPKEPQLSLLAAQCGLTLQQTQRWFRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_078 GLPLSRWLGVRDQTRRQVKPNATLEKHFLTEGHRPKEPQLSLLAAQCGLTLQQTQRWFRR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 RRNQDRPQLTKKFCEASWRFLFYLSSFVGGLSVLYHESWLWAPVMCWDRYPNQTLKPSLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_078 RRNQDRPQLTKKFCEASWRFLFYLSSFVGGLSVLYHESWLWAPVMCWDRYPNQTLKPSLY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 WWYLLELGFYLSLLIRLPFDVKRKDFKEQVIHHFVAVILMTFSYSANLLRIGSLVLLLHD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_078 WWYLLELGFYLSLLIRLPFDVKRKDFKEQVIHHFVAVILMTFSYSANLLRIGSLVLLLHD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 SSDYLLEACKMVNYMQYQQVCDALFLIFSFVFFYTRLVLFPTQILYTIYYESISNRGPFF ::::::::::::::::::::::::::::::::::::::::::::::: :::::::::::: NP_078 SSDYLLEACKMVNYMQYQQVCDALFLIFSFVFFYTRLVLFPTQILYTTYYESISNRGPFF 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 GYYFFNGLLMLLQLLHVFWSCLILRMLYSFMKKGQMEKDIRSDVEESDSSEEVAAAQEPL ::::::::::::::::::::::::::::::::::::::::::::::::::::.::::::: NP_078 GYYFFNGLLMLLQLLHVFWSCLILRMLYSFMKKGQMEKDIRSDVEESDSSEEAAAAQEPL 310 320 330 340 350 360 370 380 390 pF1KB8 QLKNGAAGGPRPAPTDGPQSRVAGRLTNRHTTAT ::::::::::::::::::.::::::::::::::: NP_078 QLKNGAAGGPRPAPTDGPRSRVAGRLTNRHTTAT 370 380 390 >>XP_016882794 (OMIM: 615334) PREDICTED: ceramide syntha (394 aa) initn: 2698 init1: 2698 opt: 2698 Z-score: 2956.5 bits: 555.9 E(85289): 6.1e-158 Smith-Waterman score: 2698; 99.2% identity (99.7% similar) in 394 aa overlap (1-394:1-394) 10 20 30 40 50 60 pF1KB8 MLSSFNEWFWQDRFWLPPNVTWTELEDRDGRVYPHPQDLLAALPLALVLLAMRLAFERFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MLSSFNEWFWQDRFWLPPNVTWTELEDRDGRVYPHPQDLLAALPLALVLLAMRLAFERFI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 GLPLSRWLGVRDQTRRQVKPNATLEKHFLTEGHRPKEPQLSLLAAQCGLTLQQTQRWFRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GLPLSRWLGVRDQTRRQVKPNATLEKHFLTEGHRPKEPQLSLLAAQCGLTLQQTQRWFRR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 RRNQDRPQLTKKFCEASWRFLFYLSSFVGGLSVLYHESWLWAPVMCWDRYPNQTLKPSLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RRNQDRPQLTKKFCEASWRFLFYLSSFVGGLSVLYHESWLWAPVMCWDRYPNQTLKPSLY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 WWYLLELGFYLSLLIRLPFDVKRKDFKEQVIHHFVAVILMTFSYSANLLRIGSLVLLLHD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 WWYLLELGFYLSLLIRLPFDVKRKDFKEQVIHHFVAVILMTFSYSANLLRIGSLVLLLHD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 SSDYLLEACKMVNYMQYQQVCDALFLIFSFVFFYTRLVLFPTQILYTIYYESISNRGPFF ::::::::::::::::::::::::::::::::::::::::::::::: :::::::::::: XP_016 SSDYLLEACKMVNYMQYQQVCDALFLIFSFVFFYTRLVLFPTQILYTTYYESISNRGPFF 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 GYYFFNGLLMLLQLLHVFWSCLILRMLYSFMKKGQMEKDIRSDVEESDSSEEVAAAQEPL ::::::::::::::::::::::::::::::::::::::::::::::::::::.::::::: XP_016 GYYFFNGLLMLLQLLHVFWSCLILRMLYSFMKKGQMEKDIRSDVEESDSSEEAAAAQEPL 310 320 330 340 350 360 370 380 390 pF1KB8 QLKNGAAGGPRPAPTDGPQSRVAGRLTNRHTTAT ::::::::::::::::::.::::::::::::::: XP_016 QLKNGAAGGPRPAPTDGPRSRVAGRLTNRHTTAT 370 380 390 >>XP_011526593 (OMIM: 615334) PREDICTED: ceramide syntha (394 aa) initn: 2698 init1: 2698 opt: 2698 Z-score: 2956.5 bits: 555.9 E(85289): 6.1e-158 Smith-Waterman score: 2698; 99.2% identity (99.7% similar) in 394 aa overlap (1-394:1-394) 10 20 30 40 50 60 pF1KB8 MLSSFNEWFWQDRFWLPPNVTWTELEDRDGRVYPHPQDLLAALPLALVLLAMRLAFERFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MLSSFNEWFWQDRFWLPPNVTWTELEDRDGRVYPHPQDLLAALPLALVLLAMRLAFERFI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 GLPLSRWLGVRDQTRRQVKPNATLEKHFLTEGHRPKEPQLSLLAAQCGLTLQQTQRWFRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GLPLSRWLGVRDQTRRQVKPNATLEKHFLTEGHRPKEPQLSLLAAQCGLTLQQTQRWFRR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 RRNQDRPQLTKKFCEASWRFLFYLSSFVGGLSVLYHESWLWAPVMCWDRYPNQTLKPSLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RRNQDRPQLTKKFCEASWRFLFYLSSFVGGLSVLYHESWLWAPVMCWDRYPNQTLKPSLY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 WWYLLELGFYLSLLIRLPFDVKRKDFKEQVIHHFVAVILMTFSYSANLLRIGSLVLLLHD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 WWYLLELGFYLSLLIRLPFDVKRKDFKEQVIHHFVAVILMTFSYSANLLRIGSLVLLLHD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 SSDYLLEACKMVNYMQYQQVCDALFLIFSFVFFYTRLVLFPTQILYTIYYESISNRGPFF ::::::::::::::::::::::::::::::::::::::::::::::: :::::::::::: XP_011 SSDYLLEACKMVNYMQYQQVCDALFLIFSFVFFYTRLVLFPTQILYTTYYESISNRGPFF 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 GYYFFNGLLMLLQLLHVFWSCLILRMLYSFMKKGQMEKDIRSDVEESDSSEEVAAAQEPL ::::::::::::::::::::::::::::::::::::::::::::::::::::.::::::: XP_011 GYYFFNGLLMLLQLLHVFWSCLILRMLYSFMKKGQMEKDIRSDVEESDSSEEAAAAQEPL 310 320 330 340 350 360 370 380 390 pF1KB8 QLKNGAAGGPRPAPTDGPQSRVAGRLTNRHTTAT ::::::::::::::::::.::::::::::::::: XP_011 QLKNGAAGGPRPAPTDGPRSRVAGRLTNRHTTAT 370 380 390 >>XP_016882793 (OMIM: 615334) PREDICTED: ceramide syntha (394 aa) initn: 2698 init1: 2698 opt: 2698 Z-score: 2956.5 bits: 555.9 E(85289): 6.1e-158 Smith-Waterman score: 2698; 99.2% identity (99.7% similar) in 394 aa overlap (1-394:1-394) 10 20 30 40 50 60 pF1KB8 MLSSFNEWFWQDRFWLPPNVTWTELEDRDGRVYPHPQDLLAALPLALVLLAMRLAFERFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MLSSFNEWFWQDRFWLPPNVTWTELEDRDGRVYPHPQDLLAALPLALVLLAMRLAFERFI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 GLPLSRWLGVRDQTRRQVKPNATLEKHFLTEGHRPKEPQLSLLAAQCGLTLQQTQRWFRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GLPLSRWLGVRDQTRRQVKPNATLEKHFLTEGHRPKEPQLSLLAAQCGLTLQQTQRWFRR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 RRNQDRPQLTKKFCEASWRFLFYLSSFVGGLSVLYHESWLWAPVMCWDRYPNQTLKPSLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RRNQDRPQLTKKFCEASWRFLFYLSSFVGGLSVLYHESWLWAPVMCWDRYPNQTLKPSLY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 WWYLLELGFYLSLLIRLPFDVKRKDFKEQVIHHFVAVILMTFSYSANLLRIGSLVLLLHD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 WWYLLELGFYLSLLIRLPFDVKRKDFKEQVIHHFVAVILMTFSYSANLLRIGSLVLLLHD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 SSDYLLEACKMVNYMQYQQVCDALFLIFSFVFFYTRLVLFPTQILYTIYYESISNRGPFF ::::::::::::::::::::::::::::::::::::::::::::::: :::::::::::: XP_016 SSDYLLEACKMVNYMQYQQVCDALFLIFSFVFFYTRLVLFPTQILYTTYYESISNRGPFF 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 GYYFFNGLLMLLQLLHVFWSCLILRMLYSFMKKGQMEKDIRSDVEESDSSEEVAAAQEPL ::::::::::::::::::::::::::::::::::::::::::::::::::::.::::::: XP_016 GYYFFNGLLMLLQLLHVFWSCLILRMLYSFMKKGQMEKDIRSDVEESDSSEEAAAAQEPL 310 320 330 340 350 360 370 380 390 pF1KB8 QLKNGAAGGPRPAPTDGPQSRVAGRLTNRHTTAT ::::::::::::::::::.::::::::::::::: XP_016 QLKNGAAGGPRPAPTDGPRSRVAGRLTNRHTTAT 370 380 390 >>XP_016882792 (OMIM: 615334) PREDICTED: ceramide syntha (394 aa) initn: 2698 init1: 2698 opt: 2698 Z-score: 2956.5 bits: 555.9 E(85289): 6.1e-158 Smith-Waterman score: 2698; 99.2% identity (99.7% similar) in 394 aa overlap (1-394:1-394) 10 20 30 40 50 60 pF1KB8 MLSSFNEWFWQDRFWLPPNVTWTELEDRDGRVYPHPQDLLAALPLALVLLAMRLAFERFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MLSSFNEWFWQDRFWLPPNVTWTELEDRDGRVYPHPQDLLAALPLALVLLAMRLAFERFI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 GLPLSRWLGVRDQTRRQVKPNATLEKHFLTEGHRPKEPQLSLLAAQCGLTLQQTQRWFRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GLPLSRWLGVRDQTRRQVKPNATLEKHFLTEGHRPKEPQLSLLAAQCGLTLQQTQRWFRR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 RRNQDRPQLTKKFCEASWRFLFYLSSFVGGLSVLYHESWLWAPVMCWDRYPNQTLKPSLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RRNQDRPQLTKKFCEASWRFLFYLSSFVGGLSVLYHESWLWAPVMCWDRYPNQTLKPSLY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 WWYLLELGFYLSLLIRLPFDVKRKDFKEQVIHHFVAVILMTFSYSANLLRIGSLVLLLHD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 WWYLLELGFYLSLLIRLPFDVKRKDFKEQVIHHFVAVILMTFSYSANLLRIGSLVLLLHD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 SSDYLLEACKMVNYMQYQQVCDALFLIFSFVFFYTRLVLFPTQILYTIYYESISNRGPFF ::::::::::::::::::::::::::::::::::::::::::::::: :::::::::::: XP_016 SSDYLLEACKMVNYMQYQQVCDALFLIFSFVFFYTRLVLFPTQILYTTYYESISNRGPFF 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 GYYFFNGLLMLLQLLHVFWSCLILRMLYSFMKKGQMEKDIRSDVEESDSSEEVAAAQEPL ::::::::::::::::::::::::::::::::::::::::::::::::::::.::::::: XP_016 GYYFFNGLLMLLQLLHVFWSCLILRMLYSFMKKGQMEKDIRSDVEESDSSEEAAAAQEPL 310 320 330 340 350 360 370 380 390 pF1KB8 QLKNGAAGGPRPAPTDGPQSRVAGRLTNRHTTAT ::::::::::::::::::.::::::::::::::: XP_016 QLKNGAAGGPRPAPTDGPRSRVAGRLTNRHTTAT 370 380 390 >>XP_011526597 (OMIM: 615334) PREDICTED: ceramide syntha (394 aa) initn: 2698 init1: 2698 opt: 2698 Z-score: 2956.5 bits: 555.9 E(85289): 6.1e-158 Smith-Waterman score: 2698; 99.2% identity (99.7% similar) in 394 aa overlap (1-394:1-394) 10 20 30 40 50 60 pF1KB8 MLSSFNEWFWQDRFWLPPNVTWTELEDRDGRVYPHPQDLLAALPLALVLLAMRLAFERFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MLSSFNEWFWQDRFWLPPNVTWTELEDRDGRVYPHPQDLLAALPLALVLLAMRLAFERFI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 GLPLSRWLGVRDQTRRQVKPNATLEKHFLTEGHRPKEPQLSLLAAQCGLTLQQTQRWFRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GLPLSRWLGVRDQTRRQVKPNATLEKHFLTEGHRPKEPQLSLLAAQCGLTLQQTQRWFRR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 RRNQDRPQLTKKFCEASWRFLFYLSSFVGGLSVLYHESWLWAPVMCWDRYPNQTLKPSLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RRNQDRPQLTKKFCEASWRFLFYLSSFVGGLSVLYHESWLWAPVMCWDRYPNQTLKPSLY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 WWYLLELGFYLSLLIRLPFDVKRKDFKEQVIHHFVAVILMTFSYSANLLRIGSLVLLLHD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 WWYLLELGFYLSLLIRLPFDVKRKDFKEQVIHHFVAVILMTFSYSANLLRIGSLVLLLHD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 SSDYLLEACKMVNYMQYQQVCDALFLIFSFVFFYTRLVLFPTQILYTIYYESISNRGPFF ::::::::::::::::::::::::::::::::::::::::::::::: :::::::::::: XP_011 SSDYLLEACKMVNYMQYQQVCDALFLIFSFVFFYTRLVLFPTQILYTTYYESISNRGPFF 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 GYYFFNGLLMLLQLLHVFWSCLILRMLYSFMKKGQMEKDIRSDVEESDSSEEVAAAQEPL ::::::::::::::::::::::::::::::::::::::::::::::::::::.::::::: XP_011 GYYFFNGLLMLLQLLHVFWSCLILRMLYSFMKKGQMEKDIRSDVEESDSSEEAAAAQEPL 310 320 330 340 350 360 370 380 390 pF1KB8 QLKNGAAGGPRPAPTDGPQSRVAGRLTNRHTTAT ::::::::::::::::::.::::::::::::::: XP_011 QLKNGAAGGPRPAPTDGPRSRVAGRLTNRHTTAT 370 380 390 394 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 09:57:39 2016 done: Fri Nov 4 09:57:40 2016 Total Scan time: 8.090 Total Display time: 0.060 Function used was FASTA [36.3.4 Apr, 2011]