Result of FASTA (omim) for
pF1KB8143
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB8143, 406 aa
1>>>pF1KB8143 406 - 406 aa - 406 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 9.7928+/-0.000391; mu= -0.1475+/- 0.025
mean_var=358.6307+/-71.460, 0's: 0 Z-trim(123.4): 326 B-trim: 0 in 0/62
Lambda= 0.067725
statistics sampled from 42894 (43264) to 42894 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.806), E-opt: 0.2 (0.507), width: 16
Scan time: 8.550
The best scores are: opt bits E(85289)
NP_005559 (OMIM: 601999) LIM/homeobox protein Lhx1 ( 406) 2863 293.1 8e-79
NP_071758 (OMIM: 605992) LIM/homeobox protein Lhx5 ( 402) 2122 220.7 4.9e-57
NP_203129 (OMIM: 262700,602146) LIM/homeobox prote ( 390) 555 67.6 6e-11
XP_016870657 (OMIM: 221750,600577) PREDICTED: LIM/ ( 373) 535 65.6 2.2e-10
XP_005263467 (OMIM: 221750,600577) PREDICTED: LIM/ ( 386) 535 65.7 2.3e-10
NP_835258 (OMIM: 221750,600577) LIM/homeobox prote ( 397) 535 65.7 2.3e-10
NP_055379 (OMIM: 221750,600577) LIM/homeobox prote ( 402) 535 65.7 2.4e-10
NP_001167618 (OMIM: 161200,602575) LIM homeobox tr ( 402) 477 60.0 1.2e-08
NP_002307 (OMIM: 161200,602575) LIM homeobox trans ( 395) 472 59.5 1.7e-08
NP_001167617 (OMIM: 161200,602575) LIM homeobox tr ( 406) 469 59.2 2.1e-08
XP_011507842 (OMIM: 600298) PREDICTED: LIM homeobo ( 279) 456 57.8 3.9e-08
NP_796372 (OMIM: 600298) LIM homeobox transcriptio ( 382) 456 57.9 4.8e-08
NP_001167540 (OMIM: 600298) LIM homeobox transcrip ( 382) 456 57.9 4.8e-08
NP_001229263 (OMIM: 608215) LIM/homeobox protein L ( 363) 445 56.8 9.8e-08
NP_001229262 (OMIM: 608215) LIM/homeobox protein L ( 366) 445 56.8 9.8e-08
NP_954629 (OMIM: 608215) LIM/homeobox protein Lhx6 ( 377) 445 56.9 1e-07
XP_011516824 (OMIM: 608215) PREDICTED: LIM/homeobo ( 378) 445 56.9 1e-07
NP_055183 (OMIM: 608215) LIM/homeobox protein Lhx6 ( 392) 445 56.9 1e-07
XP_011516823 (OMIM: 608215) PREDICTED: LIM/homeobo ( 407) 445 56.9 1.1e-07
XP_006717386 (OMIM: 603759) PREDICTED: LIM/homeobo ( 314) 433 55.6 2e-07
NP_004780 (OMIM: 603759) LIM/homeobox protein Lhx2 ( 406) 433 55.7 2.4e-07
XP_005251973 (OMIM: 608215) PREDICTED: LIM/homeobo ( 230) 423 54.5 3.2e-07
XP_016857338 (OMIM: 606066) PREDICTED: LIM/homeobo ( 378) 422 54.6 4.8e-07
NP_001014434 (OMIM: 606066) LIM/homeobox protein L ( 388) 422 54.6 4.9e-07
NP_064589 (OMIM: 606066) LIM/homeobox protein Lhx9 ( 397) 422 54.6 4.9e-07
XP_011508083 (OMIM: 606066) PREDICTED: LIM/homeobo ( 403) 422 54.6 5e-07
XP_005245407 (OMIM: 606066) PREDICTED: LIM/homeobo ( 336) 418 54.2 5.8e-07
XP_016877994 (OMIM: 609481) PREDICTED: insulin gen ( 534) 416 54.2 9e-07
NP_665804 (OMIM: 609481) insulin gene enhancer pro ( 359) 409 53.3 1.1e-06
NP_002193 (OMIM: 600366) insulin gene enhancer pro ( 349) 407 53.1 1.2e-06
NP_001243043 (OMIM: 604425) LIM/homeobox protein L ( 346) 405 52.9 1.4e-06
NP_001001933 (OMIM: 604425) LIM/homeobox protein L ( 356) 405 52.9 1.4e-06
XP_016856805 (OMIM: 604425) PREDICTED: LIM/homeobo ( 363) 405 52.9 1.5e-06
XP_016856806 (OMIM: 604425) PREDICTED: LIM/homeobo ( 363) 405 52.9 1.5e-06
XP_011508407 (OMIM: 262700,602146) PREDICTED: LIM/ ( 329) 391 51.5 3.5e-06
XP_011508408 (OMIM: 262700,602146) PREDICTED: LIM/ ( 329) 391 51.5 3.5e-06
XP_011518401 (OMIM: 186921) PREDICTED: rhombotin-1 ( 145) 379 49.9 4.6e-06
XP_011518400 (OMIM: 186921) PREDICTED: rhombotin-1 ( 145) 379 49.9 4.6e-06
XP_005271348 (OMIM: 603129) PREDICTED: LIM domain ( 165) 380 50.1 4.7e-06
NP_006760 (OMIM: 603129) LIM domain transcription ( 165) 380 50.1 4.7e-06
NP_001257357 (OMIM: 186921) rhombotin-1 isoform b ( 155) 379 50.0 4.9e-06
NP_002306 (OMIM: 186921) rhombotin-1 isoform a [Ho ( 156) 379 50.0 4.9e-06
XP_006718291 (OMIM: 186921) PREDICTED: rhombotin-1 ( 193) 379 50.1 5.6e-06
XP_011519064 (OMIM: 180386) PREDICTED: LIM domain ( 145) 371 49.2 8e-06
NP_061110 (OMIM: 180386) LIM domain only protein 3 ( 145) 371 49.2 8e-06
XP_006719174 (OMIM: 180386) PREDICTED: LIM domain ( 145) 371 49.2 8e-06
XP_011519065 (OMIM: 180386) PREDICTED: LIM domain ( 145) 371 49.2 8e-06
NP_001001395 (OMIM: 180386) LIM domain only protei ( 145) 371 49.2 8e-06
NP_001230539 (OMIM: 180386) LIM domain only protei ( 145) 371 49.2 8e-06
NP_001230538 (OMIM: 180386) LIM domain only protei ( 145) 371 49.2 8e-06
>>NP_005559 (OMIM: 601999) LIM/homeobox protein Lhx1 [Ho (406 aa)
initn: 2863 init1: 2863 opt: 2863 Z-score: 1536.1 bits: 293.1 E(85289): 8e-79
Smith-Waterman score: 2863; 100.0% identity (100.0% similar) in 406 aa overlap (1-406:1-406)
10 20 30 40 50 60
pF1KB8 MVHCAGCKRPILDRFLLNVLDRAWHVKCVQCCECKCNLTEKCFSREGKLYCKNDFFRCFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MVHCAGCKRPILDRFLLNVLDRAWHVKCVQCCECKCNLTEKCFSREGKLYCKNDFFRCFG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 TKCAGCAQGISPSDLVRRARSKVFHLNCFTCMMCNKQLSTGEELYIIDENKFVCKEDYLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 TKCAGCAQGISPSDLVRRARSKVFHLNCFTCMMCNKQLSTGEELYIIDENKFVCKEDYLS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 NSSVAKENSLHSATTGSDPSLSPDSQDPSQDDAKDSESANVSDKEAGSNENDDQNLGAKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 NSSVAKENSLHSATTGSDPSLSPDSQDPSQDDAKDSESANVSDKEAGSNENDDQNLGAKR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB8 RGPRTTIKAKQLETLKAAFAATPKPTRHIREQLAQETGLNMRVIQVWFQNRRSKERRMKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 RGPRTTIKAKQLETLKAAFAATPKPTRHIREQLAQETGLNMRVIQVWFQNRRSKERRMKQ
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB8 LSALGARRHAFFRSPRRMRPLVDRLEPGELIPNGPFSFYGDYQSEYYGPGGNYDFFPQGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 LSALGARRHAFFRSPRRMRPLVDRLEPGELIPNGPFSFYGDYQSEYYGPGGNYDFFPQGP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB8 PSSQAQTPVDLPFVPSSGPSGTPLGGLEHPLPGHHPSSEAQRFTDILAHPPGDSPSPEPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 PSSQAQTPVDLPFVPSSGPSGTPLGGLEHPLPGHHPSSEAQRFTDILAHPPGDSPSPEPS
310 320 330 340 350 360
370 380 390 400
pF1KB8 LPGPLHSMSAEVFGPSPPFSSLSVNGGASYGNHLSHPPEMNEAAVW
::::::::::::::::::::::::::::::::::::::::::::::
NP_005 LPGPLHSMSAEVFGPSPPFSSLSVNGGASYGNHLSHPPEMNEAAVW
370 380 390 400
>>NP_071758 (OMIM: 605992) LIM/homeobox protein Lhx5 [Ho (402 aa)
initn: 1209 init1: 916 opt: 2122 Z-score: 1144.9 bits: 220.7 E(85289): 4.9e-57
Smith-Waterman score: 2122; 74.6% identity (90.0% similar) in 409 aa overlap (1-406:2-402)
10 20 30 40 50
pF1KB8 MVHCAGCKRPILDRFLLNVLDRAWHVKCVQCCECKCNLTEKCFSREGKLYCKNDFFRCF
:::::::.:::::::::::::::::.::::::::: ::.:::::::::::::::::: :
NP_071 MMVHCAGCERPILDRFLLNVLDRAWHIKCVQCCECKTNLSEKCFSREGKLYCKNDFFRRF
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB8 GTKCAGCAQGISPSDLVRRARSKVFHLNCFTCMMCNKQLSTGEELYIIDENKFVCKEDYL
::::::::::::::::::.::::::::::::::.::::::::::::.:::::::::.:::
NP_071 GTKCAGCAQGISPSDLVRKARSKVFHLNCFTCMVCNKQLSTGEELYVIDENKFVCKDDYL
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB8 SNSSVAKENSLHSATTGSDPSLSPDSQDPSQDDAKDSESANVSDKEAGSNENDDQNLGAK
:.::. ::.::.:... .: ::::: :: ::: :...... ::::...:::..:: :.:
NP_071 SSSSL-KEGSLNSVSSCTDRSLSPDLQDALQDDPKETDNSTSSDKETANNENEEQNSGTK
130 140 150 160 170
180 190 200 210 220 230
pF1KB8 RRGPRTTIKAKQLETLKAAFAATPKPTRHIREQLAQETGLNMRVIQVWFQNRRSKERRMK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_071 RRGPRTTIKAKQLETLKAAFAATPKPTRHIREQLAQETGLNMRVIQVWFQNRRSKERRMK
180 190 200 210 220 230
240 250 260 270 280 290
pF1KB8 QLSALGARRHAFFRSPRRMRPLVDRLEPGELIPNGPFSFYGDYQSEYYGPGGNYDFFPQG
:::::::::::::::::::::: ::. .:.. . :...:::::..::.::.::::: .:
NP_071 QLSALGARRHAFFRSPRRMRPLGGRLDESEMLGSTPYTYYGDYQGDYYAPGSNYDFFAHG
240 250 260 270 280 290
300 310 320 330 340 350
pF1KB8 PPSSQAQTPVDLPFVPSSGPSGTPLGGLEHPLPGHHPSSEAQRFTDILAHPPGDSPSPEP
::: :::.:.: :. .:::..::::.:: :: : : ... ::::...:: :.:::::
NP_071 PPS-QAQSPADSSFLAASGPGSTPLGALEPPLAGPH-AADNPRFTDMISHP--DTPSPEP
300 310 320 330 340 350
360 370 380 390 400
pF1KB8 SLPGPLHSMSAEVF--GPSPPFSSLSVNGGASYGNHLSHP-PEMNEAAVW
.::: :: : .::: :::::: ..: ..:.. :::: ::.::::::
NP_071 GLPGTLHPMPGEVFSGGPSPPFP---MSGTSGYSGPLSHPNPELNEAAVW
360 370 380 390 400
>>NP_203129 (OMIM: 262700,602146) LIM/homeobox protein L (390 aa)
initn: 924 init1: 553 opt: 555 Z-score: 317.6 bits: 67.6 E(85289): 6e-11
Smith-Waterman score: 842; 37.0% identity (61.3% similar) in 424 aa overlap (3-398:29-389)
10 20 30
pF1KB8 MVHCAGCKRPILDRFLLNVLDRAWHVKCVQCCEC
.::::.. :::.:.:.:::: :: .:..: .:
NP_203 MMQSATVPAEGAVKGLPEMLGVPMQQIPQCAGCNQHILDKFILKVLDRHWHSSCLKCADC
10 20 30 40 50 60
40 50 60 70 80 90
pF1KB8 KCNLTEKCFSREGKLYCKNDFFRCFGTKCAGCAQGISPSDLVRRARSKVFHLNCFTCMMC
. .:...:::: :..:::.:::. :::::..: ::: :...::.:.. :.::.::.:..:
NP_203 QMQLADRCFSRAGSVYCKEDFFKRFGTKCTACQQGIPPTQVVRKAQDFVYHLHCFACIIC
70 80 90 100 110 120
100 110 120 130 140 150
pF1KB8 NKQLSTGEELYIIDENKFVCKEDYLSNSSVAKENSLHSATTGSDPSLSPDSQDPSQDDAK
:.::.::.:.:.......::::::
NP_203 NRQLATGDEFYLMEDGRLVCKEDY------------------------------------
130 140
160 170 180 190 200 210
pF1KB8 DSESANVSDKEAGSNENDDQNLGAKRRGPRTTIKAKQLETLKAAFAATPKPTRHIREQLA
:.:. .:::.. :::: ::::: :::::::: :. .:::.::.::::.
NP_203 --ETAK---------QNDDSEAGAKR--PRTTITAKQLETLKNAYKNSPKPARHVREQLS
150 160 170 180 190
220 230 240 250 260 270
pF1KB8 QETGLNMRVIQVWFQNRRSKERRMKQLSALGARRHAFFRSPRRMRPLVDRLEPGEL----
.::::.:::.::::::::.::.:.:. .: : :..: .: : . . .
NP_203 SETGLDMRVVQVWFQNRRAKEKRLKK-DAGRHRWGQFYKSVKRSRGSSKQEKESSAEDCG
200 210 220 230 240 250
280 290 300 310
pF1KB8 IPNGPFSFYGD-------YQSEYYG-----PGG---NYDFFPQGPPSSQAQ----TPVDL
. .. .:: : . .. :: :: : .: .: .: . .: .
NP_203 VSDSELSFREDQILSELGHTNRIYGNVGDVTGGQLMNGSFSMDGTGQSYQDLRDGSPYGI
260 270 280 290 300 310
320 330 340 350 360
pF1KB8 PFVPSSG---PSGTPL-GGLEHPLPGHHPSSEAQRFTDILAHP-PGDSPSPEPSLPGPLH
: ::: :: .:: .::.. . .. :.:: : : . . ::
NP_203 PQSPSSISSLPSHAPLLNGLDYTVDSN---------LGIIAHAGQGVSQTLRAMAGGPTS
320 330 340 350 360
370 380 390 400
pF1KB8 SMSAEVFGPSPPFSSLSVNGGASYGNHLSHPPEMNEAAVW
..:. : : . .. .. : :. ....:::
NP_203 DIST---GSSVGYPDFPTSPG-SWLDEMDHPPF
370 380 390
>>XP_016870657 (OMIM: 221750,600577) PREDICTED: LIM/home (373 aa)
initn: 903 init1: 531 opt: 535 Z-score: 307.3 bits: 65.6 E(85289): 2.2e-10
Smith-Waterman score: 815; 39.5% identity (59.8% similar) in 403 aa overlap (4-400:7-334)
10 20 30 40 50
pF1KB8 MVHCAGCKRPILDRFLLNVLDRAWHVKCVQCCECKCNLTEKCFSREGKLYCKNDFFR
:::: . :::::.:..::: :: ::..: .:. :.:.:::: ..:::.:::.
XP_016 MQQIPLCAGCDQHILDRFILKALDRHWHSKCLKCSDCHTPLAERCFSRGESVYCKDDFFK
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB8 CFGTKCAGCAQGISPSDLVRRARSKVFHLNCFTCMMCNKQLSTGEELYIIDENKFVCKED
::::::.: :: :...::::.. :.::.::.:..:..::.::.:.:.......::: :
XP_016 RFGTKCAACQLGIPPTQVVRRAQDFVYHLHCFACVVCKRQLATGDEFYLMEDSRLVCKAD
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB8 YLSNSSVAKENSLHSATTGSDPSLSPDSQDPSQDDAKDSESANVSDKEAGSNENDDQNLG
: :.:. . ::
XP_016 Y--------------------------------------ETAKQREAEA----------T
130
180 190 200 210 220 230
pF1KB8 AKRRGPRTTIKAKQLETLKAAFAATPKPTRHIREQLAQETGLNMRVIQVWFQNRRSKERR
::: ::::: ::::::::.:. ..:::.::.::::..::::.:::.::::::::.::.:
XP_016 AKR--PRTTITAKQLETLKSAYNTSPKPARHVREQLSSETGLDMRVVQVWFQNRRAKEKR
140 150 160 170 180 190
240 250 260 270 280 290
pF1KB8 MKQLSALGARRHAFFRSPRRMRPLV----DRLEPGELIPNGPFSFYGDYQSEYYGPGGNY
.:. .: : .::. .: : : .. :. .. :: . . .::. :
XP_016 LKK-DAGRQRWGQYFRNMKRSRGGSKSDKDSVQEGQD-SDAEVSFPDEPSLAEMGPA-NG
200 210 220 230 240
300 310 320 330 340 350
pF1KB8 DFFPQGPPSSQAQTPVDLPFVPSSGPSGTPLGGLEHP-LPGHHPSSEAQRFTDILAHPPG
. : :.. : :: :. .::: : : . : : . . ::
XP_016 LYGSLGEPTQALGRP--------SGALGNF--SLEHGGLAGPEQYREL-RPGSPYGVPP-
250 260 270 280 290
360 370 380 390 400
pF1KB8 DSPSPEPSLPGPLHSMSAEVFGPSPPFSSLS-VNGGASYGNHLSHPPEMNEAAVW
::. ::::: .:. :. : .::. : .:: : :: :
XP_016 -SPAAPQSLPGPQPLLSSLVY----PDTSLGLVPSGAPGG-----PPPMRVLAGNGPSSD
300 310 320 330 340
XP_016 LSTGSSGGYPDFPASPASWLDEVDHAQF
350 360 370
>>XP_005263467 (OMIM: 221750,600577) PREDICTED: LIM/home (386 aa)
initn: 903 init1: 531 opt: 535 Z-score: 307.1 bits: 65.7 E(85289): 2.3e-10
Smith-Waterman score: 815; 39.5% identity (59.8% similar) in 403 aa overlap (4-400:20-347)
10 20 30 40
pF1KB8 MVHCAGCKRPILDRFLLNVLDRAWHVKCVQCCECKCNLTEKCFS
:::: . :::::.:..::: :: ::..: .:. :.:.:::
XP_005 MTLNMKETRWGAPAPEIPLCAGCDQHILDRFILKALDRHWHSKCLKCSDCHTPLAERCFS
10 20 30 40 50 60
50 60 70 80 90 100
pF1KB8 REGKLYCKNDFFRCFGTKCAGCAQGISPSDLVRRARSKVFHLNCFTCMMCNKQLSTGEEL
: ..:::.:::. ::::::.: :: :...::::.. :.::.::.:..:..::.::.:.
XP_005 RGESVYCKDDFFKRFGTKCAACQLGIPPTQVVRRAQDFVYHLHCFACVVCKRQLATGDEF
70 80 90 100 110 120
110 120 130 140 150 160
pF1KB8 YIIDENKFVCKEDYLSNSSVAKENSLHSATTGSDPSLSPDSQDPSQDDAKDSESANVSDK
:.......::: :: :.:. .
XP_005 YLMEDSRLVCKADY--------------------------------------ETAKQREA
130 140
170 180 190 200 210 220
pF1KB8 EAGSNENDDQNLGAKRRGPRTTIKAKQLETLKAAFAATPKPTRHIREQLAQETGLNMRVI
:: ::: ::::: ::::::::.:. ..:::.::.::::..::::.:::.
XP_005 EA----------TAKR--PRTTITAKQLETLKSAYNTSPKPARHVREQLSSETGLDMRVV
150 160 170 180 190
230 240 250 260 270 280
pF1KB8 QVWFQNRRSKERRMKQLSALGARRHAFFRSPRRMRPLV----DRLEPGELIPNGPFSFYG
::::::::.::.:.:. .: : .::. .: : : .. :. .. ::
XP_005 QVWFQNRRAKEKRLKK-DAGRQRWGQYFRNMKRSRGGSKSDKDSVQEGQD-SDAEVSFPD
200 210 220 230 240
290 300 310 320 330
pF1KB8 DYQSEYYGPGGNYDFFPQGPPSSQAQTPVDLPFVPSSGPSGTPLGGLEHP-LPGHHPSSE
. . .::. : . : :.. : :: :. .::: : : . :
XP_005 EPSLAEMGPA-NGLYGSLGEPTQALGRP--------SGALGNF--SLEHGGLAGPEQYRE
250 260 270 280 290
340 350 360 370 380 390
pF1KB8 AQRFTDILAHPPGDSPSPEPSLPGPLHSMSAEVFGPSPPFSSLS-VNGGASYGNHLSHPP
: . . :: ::. ::::: .:. :. : .::. : .:: : ::
XP_005 L-RPGSPYGVPP--SPAAPQSLPGPQPLLSSLVY----PDTSLGLVPSGAPGG-----PP
300 310 320 330 340
400
pF1KB8 EMNEAAVW
:
XP_005 PMRVLAGNGPSSDLSTGSSGGYPDFPASPASWLDEVDHAQF
350 360 370 380
>>NP_835258 (OMIM: 221750,600577) LIM/homeobox protein L (397 aa)
initn: 903 init1: 531 opt: 535 Z-score: 306.9 bits: 65.7 E(85289): 2.3e-10
Smith-Waterman score: 815; 39.5% identity (59.8% similar) in 403 aa overlap (4-400:31-358)
10 20 30
pF1KB8 MVHCAGCKRPILDRFLLNVLDRAWHVKCVQCCE
:::: . :::::.:..::: :: ::..: .
NP_835 MLLETGLERDRARPGAAAVCTLGGTREIPLCAGCDQHILDRFILKALDRHWHSKCLKCSD
10 20 30 40 50 60
40 50 60 70 80 90
pF1KB8 CKCNLTEKCFSREGKLYCKNDFFRCFGTKCAGCAQGISPSDLVRRARSKVFHLNCFTCMM
:. :.:.:::: ..:::.:::. ::::::.: :: :...::::.. :.::.::.:..
NP_835 CHTPLAERCFSRGESVYCKDDFFKRFGTKCAACQLGIPPTQVVRRAQDFVYHLHCFACVV
70 80 90 100 110 120
100 110 120 130 140 150
pF1KB8 CNKQLSTGEELYIIDENKFVCKEDYLSNSSVAKENSLHSATTGSDPSLSPDSQDPSQDDA
:..::.::.:.:.......::: ::
NP_835 CKRQLATGDEFYLMEDSRLVCKADY-----------------------------------
130 140
160 170 180 190 200 210
pF1KB8 KDSESANVSDKEAGSNENDDQNLGAKRRGPRTTIKAKQLETLKAAFAATPKPTRHIREQL
:.:. . :: ::: ::::: ::::::::.:. ..:::.::.::::
NP_835 ---ETAKQREAEA----------TAKR--PRTTITAKQLETLKSAYNTSPKPARHVREQL
150 160 170 180 190
220 230 240 250 260
pF1KB8 AQETGLNMRVIQVWFQNRRSKERRMKQLSALGARRHAFFRSPRRMRPLV----DRLEPGE
..::::.:::.::::::::.::.:.:. .: : .::. .: : : .. :.
NP_835 SSETGLDMRVVQVWFQNRRAKEKRLKK-DAGRQRWGQYFRNMKRSRGGSKSDKDSVQEGQ
200 210 220 230 240
270 280 290 300 310 320
pF1KB8 LIPNGPFSFYGDYQSEYYGPGGNYDFFPQGPPSSQAQTPVDLPFVPSSGPSGTPLGGLEH
.. :: . . .::. : . : :.. : :: :. .:::
NP_835 D-SDAEVSFPDEPSLAEMGPA-NGLYGSLGEPTQALGRP--------SGALGNF--SLEH
250 260 270 280 290
330 340 350 360 370 380
pF1KB8 P-LPGHHPSSEAQRFTDILAHPPGDSPSPEPSLPGPLHSMSAEVFGPSPPFSSLS-VNGG
: : . : : . . :: ::. ::::: .:. :. : .::. : .:
NP_835 GGLAGPEQYREL-RPGSPYGVPP--SPAAPQSLPGPQPLLSSLVY----PDTSLGLVPSG
300 310 320 330 340 350
390 400
pF1KB8 ASYGNHLSHPPEMNEAAVW
: : :: :
NP_835 APGG-----PPPMRVLAGNGPSSDLSTGSSGGYPDFPASPASWLDEVDHAQF
360 370 380 390
>>NP_055379 (OMIM: 221750,600577) LIM/homeobox protein L (402 aa)
initn: 903 init1: 531 opt: 535 Z-score: 306.9 bits: 65.7 E(85289): 2.4e-10
Smith-Waterman score: 815; 39.5% identity (59.8% similar) in 403 aa overlap (4-400:36-363)
10 20 30
pF1KB8 MVHCAGCKRPILDRFLLNVLDRAWHVKCVQCCE
:::: . :::::.:..::: :: ::..: .
NP_055 ELGPARESAGGDLLLALLARRADLRREIPLCAGCDQHILDRFILKALDRHWHSKCLKCSD
10 20 30 40 50 60
40 50 60 70 80 90
pF1KB8 CKCNLTEKCFSREGKLYCKNDFFRCFGTKCAGCAQGISPSDLVRRARSKVFHLNCFTCMM
:. :.:.:::: ..:::.:::. ::::::.: :: :...::::.. :.::.::.:..
NP_055 CHTPLAERCFSRGESVYCKDDFFKRFGTKCAACQLGIPPTQVVRRAQDFVYHLHCFACVV
70 80 90 100 110 120
100 110 120 130 140 150
pF1KB8 CNKQLSTGEELYIIDENKFVCKEDYLSNSSVAKENSLHSATTGSDPSLSPDSQDPSQDDA
:..::.::.:.:.......::: ::
NP_055 CKRQLATGDEFYLMEDSRLVCKADY-----------------------------------
130 140 150
160 170 180 190 200 210
pF1KB8 KDSESANVSDKEAGSNENDDQNLGAKRRGPRTTIKAKQLETLKAAFAATPKPTRHIREQL
:.:. . :: ::: ::::: ::::::::.:. ..:::.::.::::
NP_055 ---ETAKQREAEA----------TAKR--PRTTITAKQLETLKSAYNTSPKPARHVREQL
160 170 180 190
220 230 240 250 260
pF1KB8 AQETGLNMRVIQVWFQNRRSKERRMKQLSALGARRHAFFRSPRRMRPLV----DRLEPGE
..::::.:::.::::::::.::.:.:. .: : .::. .: : : .. :.
NP_055 SSETGLDMRVVQVWFQNRRAKEKRLKK-DAGRQRWGQYFRNMKRSRGGSKSDKDSVQEGQ
200 210 220 230 240 250
270 280 290 300 310 320
pF1KB8 LIPNGPFSFYGDYQSEYYGPGGNYDFFPQGPPSSQAQTPVDLPFVPSSGPSGTPLGGLEH
.. :: . . .::. : . : :.. : :: :. .:::
NP_055 D-SDAEVSFPDEPSLAEMGPA-NGLYGSLGEPTQALGRP--------SGALGNF--SLEH
260 270 280 290 300
330 340 350 360 370 380
pF1KB8 P-LPGHHPSSEAQRFTDILAHPPGDSPSPEPSLPGPLHSMSAEVFGPSPPFSSLS-VNGG
: : . : : . . :: ::. ::::: .:. :. : .::. : .:
NP_055 GGLAGPEQYREL-RPGSPYGVPP--SPAAPQSLPGPQPLLSSLVY----PDTSLGLVPSG
310 320 330 340 350
390 400
pF1KB8 ASYGNHLSHPPEMNEAAVW
: : :: :
NP_055 APGG-----PPPMRVLAGNGPSSDLSTGSSGGYPDFPASPASWLDEVDHAQF
360 370 380 390 400
>>NP_001167618 (OMIM: 161200,602575) LIM homeobox transc (402 aa)
initn: 618 init1: 392 opt: 477 Z-score: 276.2 bits: 60.0 E(85289): 1.2e-08
Smith-Waterman score: 691; 34.1% identity (60.8% similar) in 390 aa overlap (4-389:56-402)
10 20 30
pF1KB8 MVHCAGCKRPILDRFLLNVLDRAWHVKCVQCCE
: ::.::: ::::. : . .:: .:.::
NP_001 DGIKMEEHALRPGPATLGVLLGSDCPHPAVCEGCQRPISDRFLMRVNESSWHEECLQCAA
30 40 50 60 70 80
40 50 60 70 80 90
pF1KB8 CKCNLTEKCFSREGKLYCKNDFFRCFGTKCAGCAQGISPSDLVRRARSKVFHLNCFTCMM
:. :: .:. :. :::::.:. . :..::.:: . :.:...: :: :.::.:: : .
NP_001 CQQALTTSCYFRDRKLYCKQDYQQLFAAKCSGCMEKIAPTEFVMRALECVYHLGCFCCCV
90 100 110 120 130 140
100 110 120 130 140 150
pF1KB8 CNKQLSTGEELYIIDENKFVCKEDYLSNSSVAKENSLHSATTGSDPSLSPDSQDPSQDDA
:..:: :.: ... :....:: :: ::..: : :.::: .: ...
NP_001 CERQLRKGDE-FVLKEGQLLCKGDY------EKEKDLLS-------SVSPDESDSVKSED
150 160 170 180 190
160 170 180 190 200 210
pF1KB8 KDSESANVSDKEAGSNENDDQNLGAKR-RGPRTTIKAKQLETLKAAFAATPKPTRHIREQ
.:.. .. . . :. . :.. .: . ::: . ..: ...::.: .. :: :..::
NP_001 EDGDMKPAKGQGSQSKGSGDDGKDPRRPKRPRTILTTQQRRAFKASFEVSSKPCRKVRET
200 210 220 230 240 250
220 230 240 250 260 270
pF1KB8 LAQETGLNMRVIQVWFQNRRSKERRMKQLSALGARRHAFFRSPRRMRPLVDRLEPGELIP
:: ::::..::.::::::.:.: ::.: :::: . .. . .:: :. .
NP_001 LAAETGLSVRVVQVWFQNQRAK---MKKL----ARRH----QQQQEQQNSQRL--GQEV-
260 270 280 290
280 290 300 310 320 330
pF1KB8 NGPFSFYGDYQSEYYGPGGNYDFFPQGPPSSQAQTPVDLPFVPSSGPSGTPLGGLEHP-L
.:.. : ..: : .::..: . . :. : : :: : .
NP_001 ---------LSSRMEGMMASYT--PLAPPQQQIVAMEQSPY----GSSDPFQQGLTPPQM
300 310 320 330 340
340 350 360 370 380
pF1KB8 PGHH--PSSEAQRFTDILAHPPGDSPSPEPSLPGPLHSMSAEVFGPSPPFSSLSVNGGAS
:: : : .. . : :: . : : . . :..:.: .: . :.. . ::
NP_001 PGDHMNPYGNDSIFHDIDSDTSLTSLSDCFLGSSDVGSLQARVGNPIDRLYSMQSSYFAS
350 360 370 380 390 400
390 400
pF1KB8 YGNHLSHPPEMNEAAVW
>>NP_002307 (OMIM: 161200,602575) LIM homeobox transcrip (395 aa)
initn: 605 init1: 404 opt: 472 Z-score: 273.7 bits: 59.5 E(85289): 1.7e-08
Smith-Waterman score: 683; 37.5% identity (65.1% similar) in 307 aa overlap (4-301:56-340)
10 20 30
pF1KB8 MVHCAGCKRPILDRFLLNVLDRAWHVKCVQCCE
: ::.::: ::::. : . .:: .:.::
NP_002 DGIKMEEHALRPGPATLGVLLGSDCPHPAVCEGCQRPISDRFLMRVNESSWHEECLQCAA
30 40 50 60 70 80
40 50 60 70 80 90
pF1KB8 CKCNLTEKCFSREGKLYCKNDFFRCFGTKCAGCAQGISPSDLVRRARSKVFHLNCFTCMM
:. :: .:. :. :::::.:. . :..::.:: . :.:...: :: :.::.:: : .
NP_002 CQQALTTSCYFRDRKLYCKQDYQQLFAAKCSGCMEKIAPTEFVMRALECVYHLGCFCCCV
90 100 110 120 130 140
100 110 120 130 140 150
pF1KB8 CNKQLSTGEELYIIDENKFVCKEDYLSNSSVAKENSLHSATTGSDPSLSPDSQDPSQDDA
:..:: :.: ... :....:: :: ::..: : :.::: .: ...
NP_002 CERQLRKGDE-FVLKEGQLLCKGDY------EKEKDLLS-------SVSPDESDSVKSED
150 160 170 180 190
160 170 180 190 200 210
pF1KB8 KDSESANVSDKEAGSNENDDQNLGAKR-RGPRTTIKAKQLETLKAAFAATPKPTRHIREQ
.:.. .. . . :. . :.. .: . ::: . ..: ...::.: .. :: :..::
NP_002 EDGDMKPAKGQGSQSKGSGDDGKDPRRPKRPRTILTTQQRRAFKASFEVSSKPCRKVRET
200 210 220 230 240 250
220 230 240 250 260
pF1KB8 LAQETGLNMRVIQVWFQNRRSKERRMKQLSALGARRHA---FFRSPRRM--RPLVDRLEP
:: ::::..::.::::::.:.: ::.: :::: .. .:. . : .:.:
NP_002 LAAETGLSVRVVQVWFQNQRAK---MKKL----ARRHQQQQEQQNSQRLGQEVLSSRME-
260 270 280 290 300
270 280 290 300 310 320
pF1KB8 GELIPNGPFSF-YGDYQSEYYGPGGNYDFFPQG--PPSSQAQTPVDLPFVPSSGPSGTPL
: . :.. . . .: :. : : :: ::
NP_002 GMMASYTPLAPPQQQIVAMEQSPYGSSDPFQQGLTPPQMPGNDSIFHDIDSDTSLTSLSD
310 320 330 340 350 360
330 340 350 360 370 380
pF1KB8 GGLEHPLPGHHPSSEAQRFTDILAHPPGDSPSPEPSLPGPLHSMSAEVFGPSPPFSSLSV
NP_002 CFLGSSDVGSLQARVGNPIDRLYSMQSSYFAS
370 380 390
>>NP_001167617 (OMIM: 161200,602575) LIM homeobox transc (406 aa)
initn: 630 init1: 404 opt: 469 Z-score: 272.0 bits: 59.2 E(85289): 2.1e-08
Smith-Waterman score: 706; 36.6% identity (63.1% similar) in 333 aa overlap (4-334:56-356)
10 20 30
pF1KB8 MVHCAGCKRPILDRFLLNVLDRAWHVKCVQCCE
: ::.::: ::::. : . .:: .:.::
NP_001 DGIKMEEHALRPGPATLGVLLGSDCPHPAVCEGCQRPISDRFLMRVNESSWHEECLQCAA
30 40 50 60 70 80
40 50 60 70 80 90
pF1KB8 CKCNLTEKCFSREGKLYCKNDFFRCFGTKCAGCAQGISPSDLVRRARSKVFHLNCFTCMM
:. :: .:. :. :::::.:. . :..::.:: . :.:...: :: :.::.:: : .
NP_001 CQQALTTSCYFRDRKLYCKQDYQQLFAAKCSGCMEKIAPTEFVMRALECVYHLGCFCCCV
90 100 110 120 130 140
100 110 120 130 140 150
pF1KB8 CNKQLSTGEELYIIDENKFVCKEDYLSNSSVAKENSLHSATTGSDPSLSPDSQDPSQDDA
:..:: :.: ... :....:: :: ::..: : :.::: .: ...
NP_001 CERQLRKGDE-FVLKEGQLLCKGDY------EKEKDLLS-------SVSPDESDSVKSED
150 160 170 180 190
160 170 180 190 200 210
pF1KB8 KDSESANVSDKEAGSNENDDQNLGAKR-RGPRTTIKAKQLETLKAAFAATPKPTRHIREQ
.:.. .. . . :. . :.. .: . ::: . ..: ...::.: .. :: :..::
NP_001 EDGDMKPAKGQGSQSKGSGDDGKDPRRPKRPRTILTTQQRRAFKASFEVSSKPCRKVRET
200 210 220 230 240 250
220 230 240 250 260 270
pF1KB8 LAQETGLNMRVIQVWFQNRRSKERRMKQLSALGARRHAFFRSPRRMRPLVDRLEPGELIP
:: ::::..::.::::::.:.: ::.: :::: . .. . .:: :: :
NP_001 LAAETGLSVRVVQVWFQNQRAK---MKKL----ARRH----QQQQEQQNSQRLGQGE--P
260 270 280 290
280 290 300 310 320 330
pF1KB8 NGPFSFYGDYQSEYYGPGGNYDFFPQGPPSSQAQTPVDLPFVPSSGPSGTPLGGLEHP-L
:: . :. : .. : .::..: . . :. : : :: : .
NP_001 -GPGQGLGQEVLSSRMEGMMASYTPLAPPQQQIVAMEQSPY----GSSDPFQQGLTPPQM
300 310 320 330 340 350
340 350 360 370 380 390
pF1KB8 PGHHPSSEAQRFTDILAHPPGDSPSPEPSLPGPLHSMSAEVFGPSPPFSSLSVNGGASYG
::.
NP_001 PGNDSIFHDIDSDTSLTSLSDCFLGSSDVGSLQARVGNPIDRLYSMQSSYFAS
360 370 380 390 400
406 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 09:58:28 2016 done: Fri Nov 4 09:58:29 2016
Total Scan time: 8.550 Total Display time: 0.040
Function used was FASTA [36.3.4 Apr, 2011]