Result of FASTA (omim) for
pF1KB8153
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB8153, 413 aa
1>>>pF1KB8153 413 - 413 aa - 413 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.8974+/-0.000343; mu= 7.8068+/- 0.021
mean_var=212.3303+/-42.835, 0's: 0 Z-trim(122.5): 23 B-trim: 1223 in 1/58
Lambda= 0.088017
statistics sampled from 40698 (40725) to 40698 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.787), E-opt: 0.2 (0.477), width: 16
Scan time: 7.780
The best scores are: opt bits E(85289)
NP_001018079 (OMIM: 607378) plasminogen activator ( 393) 919 128.9 2.1e-29
NP_056455 (OMIM: 607378) plasminogen activator inh ( 387) 763 109.1 2e-23
NP_001018077 (OMIM: 607378) plasminogen activator ( 408) 506 76.5 1.3e-13
NP_001018078 (OMIM: 607378) plasminogen activator ( 402) 336 54.9 4.2e-07
NP_958804 (OMIM: 610186) ubiquitin carboxyl-termin ( 530) 257 45.0 0.00053
>>NP_001018079 (OMIM: 607378) plasminogen activator inhi (393 aa)
initn: 593 init1: 190 opt: 919 Z-score: 648.7 bits: 128.9 E(85289): 2.1e-29
Smith-Waterman score: 919; 42.8% identity (64.1% similar) in 418 aa overlap (16-413:5-393)
10 20 30 40 50 60
pF1KB8 MKGALGSPVAAAGAAMQESFGCVVANRFHQLLDDESDPFDILREAERRRQQQLQRKRRDE
.::.:::::.::: ::.:::::::..:. :: ....
NP_001 MPGHLQEGFGCVVTNRFDQLFDDESDPFEVLKAAENKKKE---------
10 20 30 40
70 80 90 100 110
pF1KB8 AAAAAGAGPRGGRSPAGASGHR----AGAGGRRESQKERKS-LPAPVA----QRPDSPGG
:...:.: :..: : :... :: :.::::.::. :: :. .. .:
NP_001 -AGGGGVGGPGAKSAAQAAAQTNSNAAGKQLRKESQKDRKNPLPPSVGVVDKKEETQPPV
50 60 70 80 90
120 130 140 150 160 170
pF1KB8 GLQAPGQKRTPRRGEQQGWNDSRGPEGMLERAERRSYREYRPYETERQADFTAEKFPDEK
.:. : .:. :: .:: .... . .: ::: :: : .: . . .: ..
NP_001 ALKKEGIRRVGRRPDQQLQGEGKIID---RRPERRPPRERR-FEKPLEEKGEGGEFSVDR
100 110 120 130 140 150
180 190 200 210 220
pF1KB8 PGDRFDRDRPLRGRGGPRGGMRGRGRG-GPGNRVFDAFDQRGKREFERYGGNDKIA----
: :::.::::: : ::::: : : :.::.::::::.:..:.:. .
NP_001 P----IIDRPIRGRGGLGRGRGGRGRGMGRG----DGFDSRGKREFDRHSGSDRSSFSHY
160 170 180 190 200
230 240 250 260 270 280
pF1KB8 --VRTEDNMGGCGVRTWGSGKDT-SDVEPTAPMEEPTVVEESQGTPEEESPAKVPELEVE
.. ::. :: : ..::. :: .:.. . :: :: . : .. : :.:
NP_001 SGLKHEDKRGGSGSHNWGTVKDELTDLDQSNVTEETPEGEEHH--PVADTENKENEVEEV
210 220 230 240 250 260
290 300 310 320 330 340
pF1KB8 EETQVQEMTLDEWKNLQEQTRPKPEFNIRKPESTVPS---KAVVIHKSKYRDDMVKDDYE
.: .:::::::: .:.. : : :::::::. . . :. :.:::: .. ..:.
NP_001 KEEGPKEMTLDEWKAIQNKDRAKVEFNIRKPNEGADGQWKKGFVLHKSKSEEAHAEDSVM
270 280 290 300 310 320
350 360 370 380 390 400
pF1KB8 DDSHVFRKPANDITSQLEINFGNLPRPGRGARGGTRGGRGRIRRAENYGPRAEVVMQDVA
: : :::::::::::::::::.: :::::.::: :::::: : : : :.. . :
NP_001 D--HHFRKPANDITSQLEINFGDLGRPGRGGRGG-RGGRGRGGRP-NRGSRTDKSSAS-A
330 340 350 360 370 380
410
pF1KB8 PNPDDPEDFPALS
:. :::: ::::.
NP_001 PDVDDPEAFPALA
390
>>NP_056455 (OMIM: 607378) plasminogen activator inhibit (387 aa)
initn: 779 init1: 313 opt: 763 Z-score: 541.7 bits: 109.1 E(85289): 2e-23
Smith-Waterman score: 940; 43.4% identity (65.0% similar) in 412 aa overlap (16-413:5-387)
10 20 30 40 50 60
pF1KB8 MKGALGSPVAAAGAAMQESFGCVVANRFHQLLDDESDPFDILREAERRRQQQLQRKRRDE
.::.:::::.::: ::.:::::::..:. :: ....
NP_056 MPGHLQEGFGCVVTNRFDQLFDDESDPFEVLKAAENKKKE---------
10 20 30 40
70 80 90 100 110
pF1KB8 AAAAAGAGPRGGRSPAGASGHR----AGAGGRRESQKERKS-LPAPVA----QRPDSPGG
:...:.: :..: : :... :: :.::::.::. :: :. .. .:
NP_056 -AGGGGVGGPGAKSAAQAAAQTNSNAAGKQLRKESQKDRKNPLPPSVGVVDKKEETQPPV
50 60 70 80 90
120 130 140 150 160 170
pF1KB8 GLQAPGQKRTPRRGEQQGWNDSRGPEGMLERAERRSYREYRPYETERQADFTAEKFPDEK
.:. : .:. :: .:: .... . .: ::: :: : .: . . .: ..
NP_056 ALKKEGIRRVGRRPDQQLQGEGKIID---RRPERRPPRERR-FEKPLEEKGEGGEFSVDR
100 110 120 130 140 150
180 190 200 210 220 230
pF1KB8 PGDRFDRDRPLRGRGGPRGGMRGRGRG-GPGNRVFDAFDQRGKREFERYGGNDKIAVRTE
: :::.::::: : ::::: : : :.::.::::::.:..:.:. ... :
NP_056 P----IIDRPIRGRGGLGRGRGGRGRGMGRG----DGFDSRGKREFDRHSGSDRSGLKHE
160 170 180 190 200
240 250 260 270 280
pF1KB8 DNMGGCGVRTWGSGKDT-SDVEPTAPMEEPTVVEESQGTPEEESPAKVPELEVEEETQVQ
:. :: : ..::. :: .:.. . :: :: . : .. : :.: .: .
NP_056 DKRGGSGSHNWGTVKDELTDLDQSNVTEETPEGEEHH--PVADTENKENEVEEVKEEGPK
210 220 230 240 250 260
290 300 310 320 330 340
pF1KB8 EMTLDEWKNLQEQTRPKPEFNIRKPESTVPS---KAVVIHKSKYRDDMVKDDYEDDSHVF
:::::::: .:.. : : :::::::. . . :. :.:::: .. ..:. : : :
NP_056 EMTLDEWKAIQNKDRAKVEFNIRKPNEGADGQWKKGFVLHKSKSEEAHAEDSVMD--HHF
270 280 290 300 310 320
350 360 370 380 390 400
pF1KB8 RKPANDITSQLEINFGNLPRPGRGARGGTRGGRGRIRRAENYGPRAEVVMQDVAPNPDDP
::::::::::::::::.: :::::.::: :::::: : : : :.. . ::. :::
NP_056 RKPANDITSQLEINFGDLGRPGRGGRGG-RGGRGRGGRP-NRGSRTDKSSAS-APDVDDP
330 340 350 360 370 380
410
pF1KB8 EDFPALS
: ::::.
NP_056 EAFPALA
>>NP_001018077 (OMIM: 607378) plasminogen activator inhi (408 aa)
initn: 801 init1: 184 opt: 506 Z-score: 365.1 bits: 76.5 E(85289): 1.3e-13
Smith-Waterman score: 898; 41.5% identity (62.9% similar) in 431 aa overlap (16-413:5-408)
10 20 30 40 50 60
pF1KB8 MKGALGSPVAAAGAAMQESFGCVVANRFHQLLDDESDPFDILREAERRRQQQLQRKRRDE
.::.:::::.::: ::.:::::::..:. :: ....
NP_001 MPGHLQEGFGCVVTNRFDQLFDDESDPFEVLKAAENKKKE---------
10 20 30 40
70 80 90 100 110
pF1KB8 AAAAAGAGPRGGRSPAGASGHR----AGAGGRRESQKERKS-LPAPVA----QRPDSPGG
:...:.: :..: : :... :: :.::::.::. :: :. .. .:
NP_001 -AGGGGVGGPGAKSAAQAAAQTNSNAAGKQLRKESQKDRKNPLPPSVGVVDKKEETQPPV
50 60 70 80 90
120 130 140 150 160 170
pF1KB8 GLQAPGQKRTPRRGEQQGWNDSRGPEGMLERAERRSYREYRPYETERQADFTAEKFPDEK
.:. : .:. :: .:: .... . .: ::: :: : .: . . .: ..
NP_001 ALKKEGIRRVGRRPDQQLQGEGKIID---RRPERRPPRERR-FEKPLEEKGEGGEFSVDR
100 110 120 130 140 150
180 190 200 210 220
pF1KB8 PGDRFDRDRPLRGRGGPRGGMRGRGRG-GPGNRVFDAFDQRGKREFERYGGNDKIA----
: :::.::::: : ::::: : : :.::.::::::.:..:.:. .
NP_001 P----IIDRPIRGRGGLGRGRGGRGRGMGRG----DGFDSRGKREFDRHSGSDRSSFSHY
160 170 180 190 200
230 240 250 260 270
pF1KB8 --VRTEDNMGGCGVRTWGSGKDTSDVEPT----------APMEEPTVVEES-QGT---PE
.. ::. :: : ..::. :: : . ... .:.::. .: :
NP_001 SGLKHEDKRGGSGSHNWGTVKDELTESPKYIQKQISYNYSDLDQSNVTEETPEGEEHHPV
210 220 230 240 250 260
280 290 300 310 320
pF1KB8 EESPAKVPELEVEEETQVQEMTLDEWKNLQEQTRPKPEFNIRKPESTVPS---KAVVIHK
.. : :.: .: .:::::::: .:.. : : :::::::. . . :. :.::
NP_001 ADTENKENEVEEVKEEGPKEMTLDEWKAIQNKDRAKVEFNIRKPNEGADGQWKKGFVLHK
270 280 290 300 310 320
330 340 350 360 370 380
pF1KB8 SKYRDDMVKDDYEDDSHVFRKPANDITSQLEINFGNLPRPGRGARGGTRGGRGRIRRAEN
:: .. ..:. : : :::::::::::::::::.: :::::.::: :::::: : :
NP_001 SKSEEAHAEDSVMD--HHFRKPANDITSQLEINFGDLGRPGRGGRGG-RGGRGRGGRP-N
330 340 350 360 370 380
390 400 410
pF1KB8 YGPRAEVVMQDVAPNPDDPEDFPALS
: :.. . ::. :::: ::::.
NP_001 RGSRTDKSSAS-APDVDDPEAFPALA
390 400
>>NP_001018078 (OMIM: 607378) plasminogen activator inhi (402 aa)
initn: 638 init1: 194 opt: 336 Z-score: 248.5 bits: 54.9 E(85289): 4.2e-07
Smith-Waterman score: 919; 42.1% identity (63.8% similar) in 425 aa overlap (16-413:5-402)
10 20 30 40 50 60
pF1KB8 MKGALGSPVAAAGAAMQESFGCVVANRFHQLLDDESDPFDILREAERRRQQQLQRKRRDE
.::.:::::.::: ::.:::::::..:. :: ....
NP_001 MPGHLQEGFGCVVTNRFDQLFDDESDPFEVLKAAENKKKE---------
10 20 30 40
70 80 90 100 110
pF1KB8 AAAAAGAGPRGGRSPAGASGHR----AGAGGRRESQKERKS-LPAPVA----QRPDSPGG
:...:.: :..: : :... :: :.::::.::. :: :. .. .:
NP_001 -AGGGGVGGPGAKSAAQAAAQTNSNAAGKQLRKESQKDRKNPLPPSVGVVDKKEETQPPV
50 60 70 80 90
120 130 140 150 160 170
pF1KB8 GLQAPGQKRTPRRGEQQGWNDSRGPEGMLERAERRSYREYRPYETERQADFTAEKFPDEK
.:. : .:. :: .:: .... . .: ::: :: : .: . . .: ..
NP_001 ALKKEGIRRVGRRPDQQLQGEGKIID---RRPERRPPRERR-FEKPLEEKGEGGEFSVDR
100 110 120 130 140 150
180 190 200 210 220 230
pF1KB8 PGDRFDRDRPLRGRGGPRGGMRGRGRG-GPGNRVFDAFDQRGKREFERYGGNDKIAVRTE
: :::.::::: : ::::: : : :.::.::::::.:..:.:. ... :
NP_001 P----IIDRPIRGRGGLGRGRGGRGRGMGRG----DGFDSRGKREFDRHSGSDRSGLKHE
160 170 180 190 200
240 250 260 270
pF1KB8 DNMGGCGVRTWGSGKDTSDVEPT----------APMEEPTVVEES-QGT---PEEESPAK
:. :: : ..::. :: : . ... .:.::. .: : .. :
NP_001 DKRGGSGSHNWGTVKDELTESPKYIQKQISYNYSDLDQSNVTEETPEGEEHHPVADTENK
210 220 230 240 250 260
280 290 300 310 320 330
pF1KB8 VPELEVEEETQVQEMTLDEWKNLQEQTRPKPEFNIRKPESTVPS---KAVVIHKSKYRDD
:.: .: .:::::::: .:.. : : :::::::. . . :. :.:::: ..
NP_001 ENEVEEVKEEGPKEMTLDEWKAIQNKDRAKVEFNIRKPNEGADGQWKKGFVLHKSKSEEA
270 280 290 300 310 320
340 350 360 370 380 390
pF1KB8 MVKDDYEDDSHVFRKPANDITSQLEINFGNLPRPGRGARGGTRGGRGRIRRAENYGPRAE
..:. : : :::::::::::::::::.: :::::.::: :::::: : : : :..
NP_001 HAEDSVMD--HHFRKPANDITSQLEINFGDLGRPGRGGRGG-RGGRGRGGRP-NRGSRTD
330 340 350 360 370 380
400 410
pF1KB8 VVMQDVAPNPDDPEDFPALS
. ::. :::: ::::.
NP_001 KSSAS-APDVDDPEAFPALA
390 400
>>NP_958804 (OMIM: 610186) ubiquitin carboxyl-terminal h (530 aa)
initn: 214 init1: 181 opt: 257 Z-score: 192.8 bits: 45.0 E(85289): 0.00053
Smith-Waterman score: 257; 36.9% identity (63.1% similar) in 149 aa overlap (251-397:390-530)
230 240 250 260 270
pF1KB8 GNDKIAVRTEDNMGGCGVRTWGSGKDTSDVEPTAPMEEPTVVEESQGTPEEESPA-KVPE
:: : : : . .:: ... : ..::
NP_958 TSVLSQQAYVLFYIQKSEWERHSESVSRGREPRALGAEDTDRRATQGELKRDHPCLQAPE
360 370 380 390 400 410
280 290 300 310 320 330
pF1KB8 L-EVEEETQVQEMTLDEWKNLQEQTRPKPEFNIRKPESTVPSKAVVIHKSKYRDDMVKDD
: : : .:: :::.:: :::.. :::::.:: :.:.: ...:::.:::. : .
NP_958 LDERLVERATQESTLDHWKFPQEQNKTKPEFNVRKVEGTLPPNVLVIHQSKYKCGMKNHH
420 430 440 450 460 470
340 350 360 370 380 390
pF1KB8 YEDDSHVFRKPANDITSQLEINFGNLPRPGRGARGGTRGGRGRIRRAENYGPRAEVVMQD
:..: .. .. :.: .: :.: . .: :: ..:. .... :: .: :
NP_958 PEQQSSLLNLSSTTRTDQESVNTGTLA----SLQGRTRRSKGKNKHSK----RALLVCQ
480 490 500 510 520 530
400 410
pF1KB8 VAPNPDDPEDFPALS
413 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 10:02:21 2016 done: Fri Nov 4 10:02:22 2016
Total Scan time: 7.780 Total Display time: 0.000
Function used was FASTA [36.3.4 Apr, 2011]