FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8157, 549 aa 1>>>pF1KB8157 549 - 549 aa - 549 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.5576+/-0.000369; mu= 9.5710+/- 0.023 mean_var=158.3435+/-30.904, 0's: 0 Z-trim(118.3): 21 B-trim: 1400 in 1/54 Lambda= 0.101923 statistics sampled from 31109 (31130) to 31109 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.714), E-opt: 0.2 (0.365), width: 16 Scan time: 10.890 The best scores are: opt bits E(85289) NP_055181 (OMIM: 608011) guanine nucleotide-bindin ( 549) 3571 537.2 5.1e-152 NP_996561 (OMIM: 608011) guanine nucleotide-bindin ( 537) 3495 526.0 1.2e-148 NP_996562 (OMIM: 608011) guanine nucleotide-bindin ( 537) 3495 526.0 1.2e-148 NP_061940 (OMIM: 300873) guanine nucleotide-bindin ( 582) 970 154.7 7.2e-37 NP_001171748 (OMIM: 300873) guanine nucleotide-bin ( 582) 970 154.7 7.2e-37 NP_001310553 (OMIM: 609365) nucleolar GTP-binding ( 548) 356 64.4 1e-09 NP_037417 (OMIM: 609365) nucleolar GTP-binding pro ( 731) 356 64.5 1.3e-09 NP_001310552 (OMIM: 609365) nucleolar GTP-binding ( 799) 340 62.2 7.1e-09 >>NP_055181 (OMIM: 608011) guanine nucleotide-binding pr (549 aa) initn: 3571 init1: 3571 opt: 3571 Z-score: 2850.2 bits: 537.2 E(85289): 5.1e-152 Smith-Waterman score: 3571; 99.5% identity (100.0% similar) in 549 aa overlap (1-549:1-549) 10 20 30 40 50 60 pF1KB8 MKRPKLKKASKRMTCHKRYKIQKKVREHHRKLRKEAKKQGHKKPRKDPGVPNSAPFKEAL ::::::::::::::::::::::::::::::::::::::.::::::::::::::::::::: NP_055 MKRPKLKKASKRMTCHKRYKIQKKVREHHRKLRKEAKKRGHKKPRKDPGVPNSAPFKEAL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 LREAELRKQRLEELKQQQKLDRQKELEKKRKLETNPDIKPSNVEPMEKEFGLCKTENKAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 LREAELRKQRLEELKQQQKLDRQKELEKKRKLETNPDIKPSNVEPMEKEFGLCKTENKAK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 SGKQNSKKLYCQELKKVIEASDVVLEVLDARDPLGCRCPQVEEAIVQSGQKKLVLILNKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 SGKQNSKKLYCQELKKVIEASDVVLEVLDARDPLGCRCPQVEEAIVQSGQKKLVLILNKS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 DLVPKENLESWLNYLKKELPTVVFRASTKPKDKGKITKRVKAKKNAAPFRSEVCFGKEGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 DLVPKENLESWLNYLKKELPTVVFRASTKPKDKGKITKRVKAKKNAAPFRSEVCFGKEGL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 WKLLGGFQETCSKAIRVGVIGFPNVGKSSIINSLKQEQMCNVGVSMGLTRSMQVVPLDKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 WKLLGGFQETCSKAIRVGVIGFPNVGKSSIINSLKQEQMCNVGVSMGLTRSMQVVPLDKQ 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 ITIIDSPSFIVSPLNSSSALALRSPASIEVVKPMEAASAILSQADARQVVLKYTVPGYRN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 ITIIDSPSFIVSPLNSSSALALRSPASIEVVKPMEAASAILSQADARQVVLKYTVPGYRN 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 SLEFFTMLAQRRGMHQKGGIPNVEGAAKLLWSEWTGASLAYYCHPPTSWTPPPYFNESIV ::::::.::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 SLEFFTVLAQRRGMHQKGGIPNVEGAAKLLWSEWTGASLAYYCHPPTSWTPPPYFNESIV 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB8 VDMKSGFNLEELEKNNAQSIRAIKGPHLANSILFQSSGLTNGIIEEKDIHEELPKRKERK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 VDMKSGFNLEELEKNNAQSIRAIKGPHLANSILFQSSGLTNGIIEEKDIHEELPKRKERK 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB8 QEEREDDKDSDQETVDEEVDENSSGMFAAEETGEALSEETTAGQQSTRSFILDKIIEEDD :::::::::::::::::::::::::::::::::::::::::::.:::::::::::::::: NP_055 QEEREDDKDSDQETVDEEVDENSSGMFAAEETGEALSEETTAGEQSTRSFILDKIIEEDD 490 500 510 520 530 540 pF1KB8 AYDFSTDYV ::::::::: NP_055 AYDFSTDYV >>NP_996561 (OMIM: 608011) guanine nucleotide-binding pr (537 aa) initn: 3495 init1: 3495 opt: 3495 Z-score: 2790.0 bits: 526.0 E(85289): 1.2e-148 Smith-Waterman score: 3495; 99.4% identity (100.0% similar) in 537 aa overlap (13-549:1-537) 10 20 30 40 50 60 pF1KB8 MKRPKLKKASKRMTCHKRYKIQKKVREHHRKLRKEAKKQGHKKPRKDPGVPNSAPFKEAL ::::::::::::::::::::::::::.::::::::::::::::::::: NP_996 MTCHKRYKIQKKVREHHRKLRKEAKKRGHKKPRKDPGVPNSAPFKEAL 10 20 30 40 70 80 90 100 110 120 pF1KB8 LREAELRKQRLEELKQQQKLDRQKELEKKRKLETNPDIKPSNVEPMEKEFGLCKTENKAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_996 LREAELRKQRLEELKQQQKLDRQKELEKKRKLETNPDIKPSNVEPMEKEFGLCKTENKAK 50 60 70 80 90 100 130 140 150 160 170 180 pF1KB8 SGKQNSKKLYCQELKKVIEASDVVLEVLDARDPLGCRCPQVEEAIVQSGQKKLVLILNKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_996 SGKQNSKKLYCQELKKVIEASDVVLEVLDARDPLGCRCPQVEEAIVQSGQKKLVLILNKS 110 120 130 140 150 160 190 200 210 220 230 240 pF1KB8 DLVPKENLESWLNYLKKELPTVVFRASTKPKDKGKITKRVKAKKNAAPFRSEVCFGKEGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_996 DLVPKENLESWLNYLKKELPTVVFRASTKPKDKGKITKRVKAKKNAAPFRSEVCFGKEGL 170 180 190 200 210 220 250 260 270 280 290 300 pF1KB8 WKLLGGFQETCSKAIRVGVIGFPNVGKSSIINSLKQEQMCNVGVSMGLTRSMQVVPLDKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_996 WKLLGGFQETCSKAIRVGVIGFPNVGKSSIINSLKQEQMCNVGVSMGLTRSMQVVPLDKQ 230 240 250 260 270 280 310 320 330 340 350 360 pF1KB8 ITIIDSPSFIVSPLNSSSALALRSPASIEVVKPMEAASAILSQADARQVVLKYTVPGYRN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_996 ITIIDSPSFIVSPLNSSSALALRSPASIEVVKPMEAASAILSQADARQVVLKYTVPGYRN 290 300 310 320 330 340 370 380 390 400 410 420 pF1KB8 SLEFFTMLAQRRGMHQKGGIPNVEGAAKLLWSEWTGASLAYYCHPPTSWTPPPYFNESIV ::::::.::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_996 SLEFFTVLAQRRGMHQKGGIPNVEGAAKLLWSEWTGASLAYYCHPPTSWTPPPYFNESIV 350 360 370 380 390 400 430 440 450 460 470 480 pF1KB8 VDMKSGFNLEELEKNNAQSIRAIKGPHLANSILFQSSGLTNGIIEEKDIHEELPKRKERK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_996 VDMKSGFNLEELEKNNAQSIRAIKGPHLANSILFQSSGLTNGIIEEKDIHEELPKRKERK 410 420 430 440 450 460 490 500 510 520 530 540 pF1KB8 QEEREDDKDSDQETVDEEVDENSSGMFAAEETGEALSEETTAGQQSTRSFILDKIIEEDD :::::::::::::::::::::::::::::::::::::::::::.:::::::::::::::: NP_996 QEEREDDKDSDQETVDEEVDENSSGMFAAEETGEALSEETTAGEQSTRSFILDKIIEEDD 470 480 490 500 510 520 pF1KB8 AYDFSTDYV ::::::::: NP_996 AYDFSTDYV 530 >>NP_996562 (OMIM: 608011) guanine nucleotide-binding pr (537 aa) initn: 3495 init1: 3495 opt: 3495 Z-score: 2790.0 bits: 526.0 E(85289): 1.2e-148 Smith-Waterman score: 3495; 99.4% identity (100.0% similar) in 537 aa overlap (13-549:1-537) 10 20 30 40 50 60 pF1KB8 MKRPKLKKASKRMTCHKRYKIQKKVREHHRKLRKEAKKQGHKKPRKDPGVPNSAPFKEAL ::::::::::::::::::::::::::.::::::::::::::::::::: NP_996 MTCHKRYKIQKKVREHHRKLRKEAKKRGHKKPRKDPGVPNSAPFKEAL 10 20 30 40 70 80 90 100 110 120 pF1KB8 LREAELRKQRLEELKQQQKLDRQKELEKKRKLETNPDIKPSNVEPMEKEFGLCKTENKAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_996 LREAELRKQRLEELKQQQKLDRQKELEKKRKLETNPDIKPSNVEPMEKEFGLCKTENKAK 50 60 70 80 90 100 130 140 150 160 170 180 pF1KB8 SGKQNSKKLYCQELKKVIEASDVVLEVLDARDPLGCRCPQVEEAIVQSGQKKLVLILNKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_996 SGKQNSKKLYCQELKKVIEASDVVLEVLDARDPLGCRCPQVEEAIVQSGQKKLVLILNKS 110 120 130 140 150 160 190 200 210 220 230 240 pF1KB8 DLVPKENLESWLNYLKKELPTVVFRASTKPKDKGKITKRVKAKKNAAPFRSEVCFGKEGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_996 DLVPKENLESWLNYLKKELPTVVFRASTKPKDKGKITKRVKAKKNAAPFRSEVCFGKEGL 170 180 190 200 210 220 250 260 270 280 290 300 pF1KB8 WKLLGGFQETCSKAIRVGVIGFPNVGKSSIINSLKQEQMCNVGVSMGLTRSMQVVPLDKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_996 WKLLGGFQETCSKAIRVGVIGFPNVGKSSIINSLKQEQMCNVGVSMGLTRSMQVVPLDKQ 230 240 250 260 270 280 310 320 330 340 350 360 pF1KB8 ITIIDSPSFIVSPLNSSSALALRSPASIEVVKPMEAASAILSQADARQVVLKYTVPGYRN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_996 ITIIDSPSFIVSPLNSSSALALRSPASIEVVKPMEAASAILSQADARQVVLKYTVPGYRN 290 300 310 320 330 340 370 380 390 400 410 420 pF1KB8 SLEFFTMLAQRRGMHQKGGIPNVEGAAKLLWSEWTGASLAYYCHPPTSWTPPPYFNESIV ::::::.::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_996 SLEFFTVLAQRRGMHQKGGIPNVEGAAKLLWSEWTGASLAYYCHPPTSWTPPPYFNESIV 350 360 370 380 390 400 430 440 450 460 470 480 pF1KB8 VDMKSGFNLEELEKNNAQSIRAIKGPHLANSILFQSSGLTNGIIEEKDIHEELPKRKERK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_996 VDMKSGFNLEELEKNNAQSIRAIKGPHLANSILFQSSGLTNGIIEEKDIHEELPKRKERK 410 420 430 440 450 460 490 500 510 520 530 540 pF1KB8 QEEREDDKDSDQETVDEEVDENSSGMFAAEETGEALSEETTAGQQSTRSFILDKIIEEDD :::::::::::::::::::::::::::::::::::::::::::.:::::::::::::::: NP_996 QEEREDDKDSDQETVDEEVDENSSGMFAAEETGEALSEETTAGEQSTRSFILDKIIEEDD 470 480 490 500 510 520 pF1KB8 AYDFSTDYV ::::::::: NP_996 AYDFSTDYV 530 >>NP_061940 (OMIM: 300873) guanine nucleotide-binding pr (582 aa) initn: 887 init1: 384 opt: 970 Z-score: 782.9 bits: 154.7 E(85289): 7.2e-37 Smith-Waterman score: 970; 37.5% identity (69.8% similar) in 437 aa overlap (16-443:6-441) 10 20 30 40 50 pF1KB8 MKRPKLKKASKRMTCHKRYKIQKKVREHHR---KLRKEAKKQGHKKPRKDPGVPNSAPFK :: : . . :.. . ::..:.: : :..:. . . NP_061 MMKLRHKNKKPGEGSKGHKKISWPYPQPAKQNGKKATSKVPSAPHFVHPN 10 20 30 40 50 60 70 80 90 100 110 pF1KB8 EALLREAELRKQRLEELKQQQKLDRQKELEKKRKLETN-PDIKPSNVEPMEKEFGLCKTE . :::::.:. .::....:. :..: .:.: .:. :. . : .:: : . . NP_061 DHANREAELKKKWVEEMREKQQAAREQERQKRRTIESYCQDVLRRQEEFEHKEEVLQELN 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB8 NKAKSGKQNSKKLYCQELKKVIEASDVVLEVLDARDPLGCRCPQVEEAIVQS-GQKKLVL . . ..: : .:..::.: :::.:::::::::::::: :.:::.... :.::::: NP_061 MFPQLDDEATRKAYYKEFRKVVEYSDVILEVLDARDPLGCRCFQMEEAVLRAQGNKKLVL 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB8 ILNKSDLVPKENLESWLNYLKKELPTVVFRASTKPKDKGKITKRVKAKKNAAPF-RSEVC .::: :::::: .:.::.::..:::::.:.:::. . :. : . . . . .:..: NP_061 VLNKIDLVPKEVVEKWLDYLRNELPTVAFKASTQHQVKNLNRCSVPVDQASESLLKSKAC 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB8 FGKEGLWKLLGGFQET--CSKAIRVGVIGFPNVGKSSIINSLKQEQMCNVGVSMGLTRSM :: :.: ..::.. . :::::.:.:::::::.:::::. . :.::. :.:. : NP_061 FGAENLMRVLGNYCRLGEVRTHIRVGVVGLPNVGKSSLINSLKRSRACSVGAVPGITKFM 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB8 QVVPLDKQITIIDSPSFIVSPLNSSSALALRSPASIE-VVKPMEAASAILSQADARQVVL : : ::: : ..:.:... .: :: . ::. . .. .. :. . .::.. . ... NP_061 QEVYLDKFIRLLDAPGIVPGP-NSEVGTILRNCVHVQKLADPVTPVETILQRCNLEEISN 300 310 320 330 340 360 370 380 390 400 410 pF1KB8 KYTVPGYRNSLEFFTMLAQRRGMHQKGGIPNVEGAAKLLWSEWTGASLAYYCHPPTSWTP : : :.... .:.: .:.: : ..:::. . : ::: . ..:.......: ::.. : NP_061 YYGVSGFQTTEHFLTAVAHRLGKKKKGGLYSQEQAAKAVLADWVSGKISFYIPPPATHTL 350 360 370 380 390 400 420 430 440 450 460 470 pF1KB8 PPYFNESIVVDMKSGFNLEELEKNNAQSIRAIKGPHLANSILFQSSGLTNGIIEEKDIHE : ... :: .: :..:. :. : .... . NP_061 PTHLSAEIVKEMTEVFDIEDTEQANEDTMECLATGESDELLGDTDPLEMEIKLLHSPMTK 410 420 430 440 450 460 480 490 500 510 520 530 pF1KB8 ELPKRKERKQEEREDDKDSDQETVDEEVDENSSGMFAAEETGEALSEETTAGQQSTRSFI NP_061 IADAIENKTTVYKIGDLTGYCTNPNRHQMGWAKRNVDHRPKSNSMVDVCSVDRRSVLQRI 470 480 490 500 510 520 >>NP_001171748 (OMIM: 300873) guanine nucleotide-binding (582 aa) initn: 887 init1: 384 opt: 970 Z-score: 782.9 bits: 154.7 E(85289): 7.2e-37 Smith-Waterman score: 970; 37.5% identity (69.8% similar) in 437 aa overlap (16-443:6-441) 10 20 30 40 50 pF1KB8 MKRPKLKKASKRMTCHKRYKIQKKVREHHR---KLRKEAKKQGHKKPRKDPGVPNSAPFK :: : . . :.. . ::..:.: : :..:. . . NP_001 MMKLRHKNKKPGEGSKGHKKISWPYPQPAKQNGKKATSKVPSAPHFVHPN 10 20 30 40 50 60 70 80 90 100 110 pF1KB8 EALLREAELRKQRLEELKQQQKLDRQKELEKKRKLETN-PDIKPSNVEPMEKEFGLCKTE . :::::.:. .::....:. :..: .:.: .:. :. . : .:: : . . NP_001 DHANREAELKKKWVEEMREKQQAAREQERQKRRTIESYCQDVLRRQEEFEHKEEVLQELN 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB8 NKAKSGKQNSKKLYCQELKKVIEASDVVLEVLDARDPLGCRCPQVEEAIVQS-GQKKLVL . . ..: : .:..::.: :::.:::::::::::::: :.:::.... :.::::: NP_001 MFPQLDDEATRKAYYKEFRKVVEYSDVILEVLDARDPLGCRCFQMEEAVLRAQGNKKLVL 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB8 ILNKSDLVPKENLESWLNYLKKELPTVVFRASTKPKDKGKITKRVKAKKNAAPF-RSEVC .::: :::::: .:.::.::..:::::.:.:::. . :. : . . . . .:..: NP_001 VLNKIDLVPKEVVEKWLDYLRNELPTVAFKASTQHQVKNLNRCSVPVDQASESLLKSKAC 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB8 FGKEGLWKLLGGFQET--CSKAIRVGVIGFPNVGKSSIINSLKQEQMCNVGVSMGLTRSM :: :.: ..::.. . :::::.:.:::::::.:::::. . :.::. :.:. : NP_001 FGAENLMRVLGNYCRLGEVRTHIRVGVVGLPNVGKSSLINSLKRSRACSVGAVPGITKFM 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB8 QVVPLDKQITIIDSPSFIVSPLNSSSALALRSPASIE-VVKPMEAASAILSQADARQVVL : : ::: : ..:.:... .: :: . ::. . .. .. :. . .::.. . ... NP_001 QEVYLDKFIRLLDAPGIVPGP-NSEVGTILRNCVHVQKLADPVTPVETILQRCNLEEISN 300 310 320 330 340 360 370 380 390 400 410 pF1KB8 KYTVPGYRNSLEFFTMLAQRRGMHQKGGIPNVEGAAKLLWSEWTGASLAYYCHPPTSWTP : : :.... .:.: .:.: : ..:::. . : ::: . ..:.......: ::.. : NP_001 YYGVSGFQTTEHFLTAVAHRLGKKKKGGLYSQEQAAKAVLADWVSGKISFYIPPPATHTL 350 360 370 380 390 400 420 430 440 450 460 470 pF1KB8 PPYFNESIVVDMKSGFNLEELEKNNAQSIRAIKGPHLANSILFQSSGLTNGIIEEKDIHE : ... :: .: :..:. :. : .... . NP_001 PTHLSAEIVKEMTEVFDIEDTEQANEDTMECLATGESDELLGDTDPLEMEIKLLHSPMTK 410 420 430 440 450 460 480 490 500 510 520 530 pF1KB8 ELPKRKERKQEEREDDKDSDQETVDEEVDENSSGMFAAEETGEALSEETTAGQQSTRSFI NP_001 IADAIENKTTVYKIGDLTGYCTNPNRHQMGWAKRNVDHRPKSNSMVDVCSVDRRSVLQRI 470 480 490 500 510 520 >>NP_001310553 (OMIM: 609365) nucleolar GTP-binding prot (548 aa) initn: 584 init1: 177 opt: 356 Z-score: 295.3 bits: 64.4 E(85289): 1e-09 Smith-Waterman score: 585; 29.8% identity (60.1% similar) in 426 aa overlap (109-502:3-405) 80 90 100 110 120 130 pF1KB8 KLDRQKELEKKRKLETNPDIKPSNVEPMEKEFGLCKTENKAKSGKQNSKKLYCQELKKVI : :: . .. : .::... :: ::: NP_001 MIESGLINEAQEEIYKKGQSKRIW-GELYKVI 10 20 30 140 150 160 170 180 190 pF1KB8 EASDVVLEVLDARDPLGCRCPQVEEAIVQ-SGQKKLVLILNKSDLVPKENLESWLNYLKK ..::::..:::::::.: : :..: . . . :.:...::: :::: . :. :.. NP_001 DSSDVVVQVLDARDPMGTRSPHIETYLKKEKPWKHLIFVLNKCDLVPTWATKRWVAVLSQ 40 50 60 70 80 90 200 210 220 230 240 250 pF1KB8 ELPTVVFRAS-TKPKDKGKITKRVKAKKNAAPFRSEVCFGKEGLWKLLGGFQETCSKAIR . ::..:.:: :.: :: . . .. ::: .: .: : NP_001 DYPTLAFHASLTNPFGKGAFIQLLRQ------------FGK----------LHTDKKQIS 100 110 120 260 270 280 290 300 310 pF1KB8 VGVIGFPNVGKSSIINSLKQEQMCNVGVSMGLTRSMQVVPLDKQITIIDSPSFIVSPLNS :: ::.:::::::.::.:.....:::. : :. : . : ..: .:: :. . .: NP_001 VGFIGYPNVGKSSVINTLRSKKVCNVAPIAGETKVWQYITLMRRIFLIDCPGVVYPSEDS 130 140 150 160 170 180 320 330 340 350 360 370 pF1KB8 SSALALRSPASIEVVK-PMEAASAILSQADARQVVLKYTVPGYRNSLEFFTMLAQRRGMH . ..:.. ...: .: : . .:.: .: . . : . ...:. .:. :: : : NP_001 ETDIVLKGVVQVEKIKSPEDHIGAVLERAKPEYISKTYKIDSWENAEDFLEKLAFRTGKL 190 200 210 220 230 240 380 390 400 410 420 430 pF1KB8 QKGGIPNVEGAAKLLWSEWTGASLAYYCHPPTS--WTPP---PYFNESIVVDMKSGFNLE ::: :... ..:.. ..: . . .. .::.. . : : . .: . .. : NP_001 LKGGEPDLQTVGKMVLNDWQRGRIPFFVKPPNAEPLVAPQLLPSSSLEVVPEAAQNNPGE 250 260 270 280 290 300 440 450 460 pF1KB8 ELEKNNAQSIRAI------KGPHL-ANS----ILF---QSSGLTNGI----------IEE :. .. ... ..: .. : ::. :: :. : : . .: NP_001 EVTETAGEGSESIIKEETEENSHCDANTEMQQILTRVRQNFGKINVVPQFSGDDLVPVEV 310 320 330 340 350 360 470 480 490 500 510 520 pF1KB8 KDIHEELPKRKERKQEEREDDKDSDQETVDEEVDENSSGMFAAEETGEALSEETTAGQQS .:..::: . .....::.:...:. .:. .: .:: NP_001 SDLEEELESFSDEEEEEQEQQRDDAEESSSEPEEENVGNDTKAVIKALDEKIAKYQKFLD 370 380 390 400 410 420 530 540 pF1KB8 TRSFILDKIIEEDDAYDFSTDYV NP_001 KAKAKKFSAVRISKGLSEKIFAKPEEQRKTLEEDVDDRAPSKKGKKRKAQREEEQEHSNK 430 440 450 460 470 480 >>NP_037417 (OMIM: 609365) nucleolar GTP-binding protein (731 aa) initn: 584 init1: 177 opt: 356 Z-score: 293.6 bits: 64.5 E(85289): 1.3e-09 Smith-Waterman score: 580; 30.1% identity (60.7% similar) in 412 aa overlap (123-502:200-588) 100 110 120 130 140 150 pF1KB8 ETNPDIKPSNVEPMEKEFGLCKTENKAKSGKQNSKKLYCQELKKVIEASDVVLEVLDARD : .::... :: :::..::::..:::::: NP_037 STESYDQGKDRDLVTEDTGVRNEAQEEIYKKGQSKRIW-GELYKVIDSSDVVVQVLDARD 170 180 190 200 210 220 160 170 180 190 200 210 pF1KB8 PLGCRCPQVEEAIVQ-SGQKKLVLILNKSDLVPKENLESWLNYLKKELPTVVFRAS-TKP :.: : :..: . . . :.:...::: :::: . :. :... ::..:.:: :.: NP_037 PMGTRSPHIETYLKKEKPWKHLIFVLNKCDLVPTWATKRWVAVLSQDYPTLAFHASLTNP 230 240 250 260 270 280 220 230 240 250 260 270 pF1KB8 KDKGKITKRVKAKKNAAPFRSEVCFGKEGLWKLLGGFQETCSKAIRVGVIGFPNVGKSSI :: . . .. ::: .: .: : :: ::.:::::::. NP_037 FGKGAFIQLLRQ------------FGK----------LHTDKKQISVGFIGYPNVGKSSV 290 300 310 320 280 290 300 310 320 330 pF1KB8 INSLKQEQMCNVGVSMGLTRSMQVVPLDKQITIIDSPSFIVSPLNSSSALALRSPASIEV ::.:.....:::. : :. : . : ..: .:: :. . .: . ..:.. ...: NP_037 INTLRSKKVCNVAPIAGETKVWQYITLMRRIFLIDCPGVVYPSEDSETDIVLKGVVQVEK 330 340 350 360 370 380 340 350 360 370 380 pF1KB8 VK-PMEAASAILSQADARQVVLKYTVPGYRNSLEFFTMLAQRRGMHQKGGIPNVEGAAKL .: : . .:.: .: . . : . ...:. .:. :: : : ::: :... ..:. NP_037 IKSPEDHIGAVLERAKPEYISKTYKIDSWENAEDFLEKLAFRTGKLLKGGEPDLQTVGKM 390 400 410 420 430 440 390 400 410 420 430 440 pF1KB8 LWSEWTGASLAYYCHPPTS--WTPP---PYFNESIVVDMKSGFNLEELEKNNAQSIRAI- . ..: . . .. .::.. . : : . .: . .. ::. .. ... ..: NP_037 VLNDWQRGRIPFFVKPPNAEPLVAPQLLPSSSLEVVPEAAQNNPGEEVTETAGEGSESII 450 460 470 480 490 500 450 460 470 480 pF1KB8 -----KGPHL-ANS----ILF---QSSGLTNGI----------IEEKDIHEELPKRKERK .. : ::. :: :. : : . .: .:..::: . .... NP_037 KEETEENSHCDANTEMQQILTRVRQNFGKINVVPQFSGDDLVPVEVSDLEEELESFSDEE 510 520 530 540 550 560 490 500 510 520 530 540 pF1KB8 QEEREDDKDSDQETVDEEVDENSSGMFAAEETGEALSEETTAGQQSTRSFILDKIIEEDD .::.:...:. .:. .: .:: NP_037 EEEQEQQRDDAEESSSEPEEENVGNDTKAVIKALDEKIAKYQKFLDKAKAKKFSAVRISK 570 580 590 600 610 620 >>NP_001310552 (OMIM: 609365) nucleolar GTP-binding prot (799 aa) initn: 584 init1: 177 opt: 340 Z-score: 280.3 bits: 62.2 E(85289): 7.1e-09 Smith-Waterman score: 537; 27.9% identity (56.8% similar) in 458 aa overlap (123-502:200-656) 100 110 120 130 140 150 pF1KB8 ETNPDIKPSNVEPMEKEFGLCKTENKAKSGKQNSKKLYCQELKKVIEASDVVLEVLDARD : .::... :: :::..::::..:::::: NP_001 STESYDQGKDRDLVTEDTGVRNEAQEEIYKKGQSKRIW-GELYKVIDSSDVVVQVLDARD 170 180 190 200 210 220 160 170 180 190 200 210 pF1KB8 PLGCRCPQVEEAIVQ-SGQKKLVLILNKSDLVPKENLESWLNYLKKELPTVVFRAS-TKP :.: : :..: . . . :.:...::: :::: . :. :... ::..:.:: :.: NP_001 PMGTRSPHIETYLKKEKPWKHLIFVLNKCDLVPTWATKRWVAVLSQDYPTLAFHASLTNP 230 240 250 260 270 280 220 230 240 pF1KB8 KDKGKITKRVKAKKNAAPFRSEVCFGKEGL------W-----------KLLGGFQ----- :: . . .. . . .. .: :: : . : :. NP_001 FGKGAFIQLLRQFGKPWHLTFHALLGFPGLLCILCPWSPCSFYVLWLERALPKFKLQIPG 290 300 310 320 330 340 250 260 270 280 pF1KB8 -------------------ETCS-----KAIRVGVIGFPNVGKSSIINSLKQEQMCNVGV .:: : : :: ::.:::::::.::.:.....:::. NP_001 QTSAPEGSRGTRLPYQILKASCSLHTDKKQISVGFIGYPNVGKSSVINTLRSKKVCNVAP 350 360 370 380 390 400 290 300 310 320 330 340 pF1KB8 SMGLTRSMQVVPLDKQITIIDSPSFIVSPLNSSSALALRSPASIEVVK-PMEAASAILSQ : :. : . : ..: .:: :. . .: . ..:.. ...: .: : . .:.: . NP_001 IAGETKVWQYITLMRRIFLIDCPGVVYPSEDSETDIVLKGVVQVEKIKSPEDHIGAVLER 410 420 430 440 450 460 350 360 370 380 390 400 pF1KB8 ADARQVVLKYTVPGYRNSLEFFTMLAQRRGMHQKGGIPNVEGAAKLLWSEWTGASLAYYC : . . : . ...:. .:. :: : : ::: :... ..:.. ..: . . .. NP_001 AKPEYISKTYKIDSWENAEDFLEKLAFRTGKLLKGGEPDLQTVGKMVLNDWQRGRIPFFV 470 480 490 500 510 520 410 420 430 440 450 pF1KB8 HPPTS--WTPP---PYFNESIVVDMKSGFNLEELEKNNAQSIRAI------KGPHL-ANS .::.. . : : . .: . .. ::. .. ... ..: .. : ::. NP_001 KPPNAEPLVAPQLLPSSSLEVVPEAAQNNPGEEVTETAGEGSESIIKEETEENSHCDANT 530 540 550 560 570 580 460 470 480 490 pF1KB8 ----ILF---QSSGLTNGI----------IEEKDIHEELPKRKERKQEEREDDKDSDQET :: :. : : . .: .:..::: . .....::.:...:. .:. NP_001 EMQQILTRVRQNFGKINVVPQFSGDDLVPVEVSDLEEELESFSDEEEEEQEQQRDDAEES 590 600 610 620 630 640 500 510 520 530 540 pF1KB8 VDEEVDENSSGMFAAEETGEALSEETTAGQQSTRSFILDKIIEEDDAYDFSTDYV .: .:: NP_001 SSEPEEENVGNDTKAVIKALDEKIAKYQKFLDKAKAKKFSAVRISKGLSEKIFAKPEEQR 650 660 670 680 690 700 549 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 10:05:10 2016 done: Fri Nov 4 10:05:11 2016 Total Scan time: 10.890 Total Display time: 0.060 Function used was FASTA [36.3.4 Apr, 2011]