FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8165, 496 aa 1>>>pF1KB8165 496 - 496 aa - 496 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 13.6751+/-0.000584; mu= -24.3970+/- 0.035 mean_var=614.2394+/-135.126, 0's: 0 Z-trim(116.8): 1493 B-trim: 578 in 1/55 Lambda= 0.051749 statistics sampled from 26126 (28321) to 26126 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.679), E-opt: 0.2 (0.332), width: 16 Scan time: 8.650 The best scores are: opt bits E(85289) XP_016885062 (OMIM: 311550) PREDICTED: cyclin-depe ( 496) 3262 259.4 1.8e-68 XP_016885061 (OMIM: 311550) PREDICTED: cyclin-depe ( 496) 3262 259.4 1.8e-68 XP_016885060 (OMIM: 311550) PREDICTED: cyclin-depe ( 496) 3262 259.4 1.8e-68 NP_006192 (OMIM: 311550) cyclin-dependent kinase 1 ( 496) 3262 259.4 1.8e-68 XP_016885059 (OMIM: 311550) PREDICTED: cyclin-depe ( 496) 3262 259.4 1.8e-68 NP_148978 (OMIM: 311550) cyclin-dependent kinase 1 ( 502) 3262 259.4 1.8e-68 XP_016885058 (OMIM: 311550) PREDICTED: cyclin-depe ( 543) 3262 259.4 1.9e-68 NP_001163931 (OMIM: 311550) cyclin-dependent kinas ( 570) 3262 259.4 2e-68 XP_011542229 (OMIM: 311550) PREDICTED: cyclin-depe ( 497) 3180 253.2 1.2e-66 XP_011542230 (OMIM: 311550) PREDICTED: cyclin-depe ( 497) 3180 253.2 1.2e-66 XP_011542227 (OMIM: 311550) PREDICTED: cyclin-depe ( 497) 3180 253.2 1.2e-66 XP_011542226 (OMIM: 311550) PREDICTED: cyclin-depe ( 497) 3180 253.2 1.2e-66 XP_011542228 (OMIM: 311550) PREDICTED: cyclin-depe ( 497) 3180 253.2 1.2e-66 XP_011542225 (OMIM: 311550) PREDICTED: cyclin-depe ( 503) 3180 253.2 1.2e-66 XP_011542224 (OMIM: 311550) PREDICTED: cyclin-depe ( 540) 3180 253.3 1.3e-66 XP_011542223 (OMIM: 311550) PREDICTED: cyclin-depe ( 544) 3180 253.3 1.3e-66 XP_011542222 (OMIM: 311550) PREDICTED: cyclin-depe ( 571) 3180 253.3 1.4e-66 NP_002586 (OMIM: 603440) cyclin-dependent kinase 1 ( 523) 2318 188.9 3e-47 XP_016874895 (OMIM: 603440) PREDICTED: cyclin-depe ( 523) 2318 188.9 3e-47 NP_001163935 (OMIM: 603440) cyclin-dependent kinas ( 523) 2318 188.9 3e-47 XP_016874894 (OMIM: 603440) PREDICTED: cyclin-depe ( 523) 2318 188.9 3e-47 NP_997667 (OMIM: 169190) cyclin-dependent kinase 1 ( 474) 1982 163.8 1e-39 NP_002587 (OMIM: 169190) cyclin-dependent kinase 1 ( 474) 1982 163.8 1e-39 XP_011507904 (OMIM: 169190) PREDICTED: cyclin-depe ( 542) 1982 163.8 1.1e-39 NP_997668 (OMIM: 169190) cyclin-dependent kinase 1 ( 504) 1958 162.0 3.6e-39 XP_016856912 (OMIM: 169190) PREDICTED: cyclin-depe ( 572) 1958 162.1 4e-39 XP_016867811 (OMIM: 610679) PREDICTED: cyclin-depe ( 423) 1237 108.1 5.1e-23 NP_001274065 (OMIM: 610679) cyclin-dependent kinas ( 423) 1237 108.1 5.1e-23 XP_016867809 (OMIM: 610679) PREDICTED: cyclin-depe ( 423) 1237 108.1 5.1e-23 XP_005250495 (OMIM: 610679) PREDICTED: cyclin-depe ( 423) 1237 108.1 5.1e-23 XP_005250496 (OMIM: 610679) PREDICTED: cyclin-depe ( 423) 1237 108.1 5.1e-23 XP_016867810 (OMIM: 610679) PREDICTED: cyclin-depe ( 423) 1237 108.1 5.1e-23 XP_005250493 (OMIM: 610679) PREDICTED: cyclin-depe ( 450) 1237 108.1 5.4e-23 NP_036527 (OMIM: 610679) cyclin-dependent kinase 1 ( 451) 1237 108.1 5.4e-23 XP_011514608 (OMIM: 610679) PREDICTED: cyclin-depe ( 469) 1237 108.1 5.5e-23 NP_001274064 (OMIM: 610679) cyclin-dependent kinas ( 469) 1237 108.1 5.5e-23 XP_016874896 (OMIM: 603440) PREDICTED: cyclin-depe ( 502) 1217 106.7 1.6e-22 XP_005246839 (OMIM: 616147) PREDICTED: cyclin-depe ( 384) 1174 103.4 1.3e-21 NP_631897 (OMIM: 616147) cyclin-dependent kinase 1 ( 384) 1174 103.4 1.3e-21 XP_005246838 (OMIM: 616147) PREDICTED: cyclin-depe ( 435) 1174 103.4 1.4e-21 NP_001248364 (OMIM: 616147) cyclin-dependent kinas ( 429) 1149 101.5 4.9e-21 XP_011509952 (OMIM: 616147) PREDICTED: cyclin-depe ( 412) 1146 101.3 5.6e-21 NP_001248365 (OMIM: 616147) cyclin-dependent kinas ( 400) 1141 100.9 7.1e-21 NP_004926 (OMIM: 123831,616342) cyclin-dependent-l ( 292) 1133 100.2 8.6e-21 NP_001274066 (OMIM: 610679) cyclin-dependent kinas ( 340) 1104 98.1 4.3e-20 NP_001249 (OMIM: 123828) cyclin-dependent kinase 3 ( 305) 1082 96.4 1.2e-19 NP_001789 (OMIM: 116953) cyclin-dependent kinase 2 ( 298) 1062 94.9 3.4e-19 XP_005270360 (OMIM: 116940) PREDICTED: cyclin-depe ( 297) 1056 94.4 4.7e-19 NP_001777 (OMIM: 116940) cyclin-dependent kinase 1 ( 297) 1056 94.4 4.7e-19 NP_001307847 (OMIM: 116940) cyclin-dependent kinas ( 297) 1056 94.4 4.7e-19 >>XP_016885062 (OMIM: 311550) PREDICTED: cyclin-dependen (496 aa) initn: 3262 init1: 3262 opt: 3262 Z-score: 1350.4 bits: 259.4 E(85289): 1.8e-68 Smith-Waterman score: 3262; 100.0% identity (100.0% similar) in 496 aa overlap (1-496:1-496) 10 20 30 40 50 60 pF1KB8 MDRMKKIKRQLSMTLRGGRGIDKTNGAPEQIGLDESGGGGGSDPGEAPTRAAPGELRSAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MDRMKKIKRQLSMTLRGGRGIDKTNGAPEQIGLDESGGGGGSDPGEAPTRAAPGELRSAR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 GPLSSAPEIVHEDLKMGSDGESDQASATSSDEVQSPVRVRMRNHPPRKISTEDINKRLSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GPLSSAPEIVHEDLKMGSDGESDQASATSSDEVQSPVRVRMRNHPPRKISTEDINKRLSL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 PADIRLPEGYLEKLTLNSPIFDKPLSRRLRRVSLSEIGFGKLETYIKLDKLGEGTYATVY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PADIRLPEGYLEKLTLNSPIFDKPLSRRLRRVSLSEIGFGKLETYIKLDKLGEGTYATVY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 KGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTEKSLTLVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTEKSLTLVF 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 EYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGEL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 KLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 LFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYNYPKYRAEALLSHAPRLDSDGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYNYPKYRAEALLSHAPRLDSDGA 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB8 DLLTKLLQFEGRNRISAEDAMKHPFFLSLGERIHKLPDTTSIFALKEIQLQKEASLRSSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DLLTKLLQFEGRNRISAEDAMKHPFFLSLGERIHKLPDTTSIFALKEIQLQKEASLRSSS 430 440 450 460 470 480 490 pF1KB8 MPDSGRPAFRVVDTEF :::::::::::::::: XP_016 MPDSGRPAFRVVDTEF 490 >>XP_016885061 (OMIM: 311550) PREDICTED: cyclin-dependen (496 aa) initn: 3262 init1: 3262 opt: 3262 Z-score: 1350.4 bits: 259.4 E(85289): 1.8e-68 Smith-Waterman score: 3262; 100.0% identity (100.0% similar) in 496 aa overlap (1-496:1-496) 10 20 30 40 50 60 pF1KB8 MDRMKKIKRQLSMTLRGGRGIDKTNGAPEQIGLDESGGGGGSDPGEAPTRAAPGELRSAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MDRMKKIKRQLSMTLRGGRGIDKTNGAPEQIGLDESGGGGGSDPGEAPTRAAPGELRSAR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 GPLSSAPEIVHEDLKMGSDGESDQASATSSDEVQSPVRVRMRNHPPRKISTEDINKRLSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GPLSSAPEIVHEDLKMGSDGESDQASATSSDEVQSPVRVRMRNHPPRKISTEDINKRLSL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 PADIRLPEGYLEKLTLNSPIFDKPLSRRLRRVSLSEIGFGKLETYIKLDKLGEGTYATVY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PADIRLPEGYLEKLTLNSPIFDKPLSRRLRRVSLSEIGFGKLETYIKLDKLGEGTYATVY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 KGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTEKSLTLVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTEKSLTLVF 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 EYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGEL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 KLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 LFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYNYPKYRAEALLSHAPRLDSDGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYNYPKYRAEALLSHAPRLDSDGA 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB8 DLLTKLLQFEGRNRISAEDAMKHPFFLSLGERIHKLPDTTSIFALKEIQLQKEASLRSSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DLLTKLLQFEGRNRISAEDAMKHPFFLSLGERIHKLPDTTSIFALKEIQLQKEASLRSSS 430 440 450 460 470 480 490 pF1KB8 MPDSGRPAFRVVDTEF :::::::::::::::: XP_016 MPDSGRPAFRVVDTEF 490 >>XP_016885060 (OMIM: 311550) PREDICTED: cyclin-dependen (496 aa) initn: 3262 init1: 3262 opt: 3262 Z-score: 1350.4 bits: 259.4 E(85289): 1.8e-68 Smith-Waterman score: 3262; 100.0% identity (100.0% similar) in 496 aa overlap (1-496:1-496) 10 20 30 40 50 60 pF1KB8 MDRMKKIKRQLSMTLRGGRGIDKTNGAPEQIGLDESGGGGGSDPGEAPTRAAPGELRSAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MDRMKKIKRQLSMTLRGGRGIDKTNGAPEQIGLDESGGGGGSDPGEAPTRAAPGELRSAR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 GPLSSAPEIVHEDLKMGSDGESDQASATSSDEVQSPVRVRMRNHPPRKISTEDINKRLSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GPLSSAPEIVHEDLKMGSDGESDQASATSSDEVQSPVRVRMRNHPPRKISTEDINKRLSL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 PADIRLPEGYLEKLTLNSPIFDKPLSRRLRRVSLSEIGFGKLETYIKLDKLGEGTYATVY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PADIRLPEGYLEKLTLNSPIFDKPLSRRLRRVSLSEIGFGKLETYIKLDKLGEGTYATVY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 KGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTEKSLTLVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTEKSLTLVF 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 EYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGEL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 KLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 LFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYNYPKYRAEALLSHAPRLDSDGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYNYPKYRAEALLSHAPRLDSDGA 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB8 DLLTKLLQFEGRNRISAEDAMKHPFFLSLGERIHKLPDTTSIFALKEIQLQKEASLRSSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DLLTKLLQFEGRNRISAEDAMKHPFFLSLGERIHKLPDTTSIFALKEIQLQKEASLRSSS 430 440 450 460 470 480 490 pF1KB8 MPDSGRPAFRVVDTEF :::::::::::::::: XP_016 MPDSGRPAFRVVDTEF 490 >>NP_006192 (OMIM: 311550) cyclin-dependent kinase 16 is (496 aa) initn: 3262 init1: 3262 opt: 3262 Z-score: 1350.4 bits: 259.4 E(85289): 1.8e-68 Smith-Waterman score: 3262; 100.0% identity (100.0% similar) in 496 aa overlap (1-496:1-496) 10 20 30 40 50 60 pF1KB8 MDRMKKIKRQLSMTLRGGRGIDKTNGAPEQIGLDESGGGGGSDPGEAPTRAAPGELRSAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 MDRMKKIKRQLSMTLRGGRGIDKTNGAPEQIGLDESGGGGGSDPGEAPTRAAPGELRSAR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 GPLSSAPEIVHEDLKMGSDGESDQASATSSDEVQSPVRVRMRNHPPRKISTEDINKRLSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 GPLSSAPEIVHEDLKMGSDGESDQASATSSDEVQSPVRVRMRNHPPRKISTEDINKRLSL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 PADIRLPEGYLEKLTLNSPIFDKPLSRRLRRVSLSEIGFGKLETYIKLDKLGEGTYATVY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 PADIRLPEGYLEKLTLNSPIFDKPLSRRLRRVSLSEIGFGKLETYIKLDKLGEGTYATVY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 KGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTEKSLTLVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 KGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTEKSLTLVF 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 EYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 EYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGEL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 KLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 KLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 LFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYNYPKYRAEALLSHAPRLDSDGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 LFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYNYPKYRAEALLSHAPRLDSDGA 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB8 DLLTKLLQFEGRNRISAEDAMKHPFFLSLGERIHKLPDTTSIFALKEIQLQKEASLRSSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 DLLTKLLQFEGRNRISAEDAMKHPFFLSLGERIHKLPDTTSIFALKEIQLQKEASLRSSS 430 440 450 460 470 480 490 pF1KB8 MPDSGRPAFRVVDTEF :::::::::::::::: NP_006 MPDSGRPAFRVVDTEF 490 >>XP_016885059 (OMIM: 311550) PREDICTED: cyclin-dependen (496 aa) initn: 3262 init1: 3262 opt: 3262 Z-score: 1350.4 bits: 259.4 E(85289): 1.8e-68 Smith-Waterman score: 3262; 100.0% identity (100.0% similar) in 496 aa overlap (1-496:1-496) 10 20 30 40 50 60 pF1KB8 MDRMKKIKRQLSMTLRGGRGIDKTNGAPEQIGLDESGGGGGSDPGEAPTRAAPGELRSAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MDRMKKIKRQLSMTLRGGRGIDKTNGAPEQIGLDESGGGGGSDPGEAPTRAAPGELRSAR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 GPLSSAPEIVHEDLKMGSDGESDQASATSSDEVQSPVRVRMRNHPPRKISTEDINKRLSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GPLSSAPEIVHEDLKMGSDGESDQASATSSDEVQSPVRVRMRNHPPRKISTEDINKRLSL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 PADIRLPEGYLEKLTLNSPIFDKPLSRRLRRVSLSEIGFGKLETYIKLDKLGEGTYATVY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PADIRLPEGYLEKLTLNSPIFDKPLSRRLRRVSLSEIGFGKLETYIKLDKLGEGTYATVY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 KGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTEKSLTLVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTEKSLTLVF 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 EYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGEL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 KLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 LFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYNYPKYRAEALLSHAPRLDSDGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYNYPKYRAEALLSHAPRLDSDGA 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB8 DLLTKLLQFEGRNRISAEDAMKHPFFLSLGERIHKLPDTTSIFALKEIQLQKEASLRSSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DLLTKLLQFEGRNRISAEDAMKHPFFLSLGERIHKLPDTTSIFALKEIQLQKEASLRSSS 430 440 450 460 470 480 490 pF1KB8 MPDSGRPAFRVVDTEF :::::::::::::::: XP_016 MPDSGRPAFRVVDTEF 490 >>NP_148978 (OMIM: 311550) cyclin-dependent kinase 16 is (502 aa) initn: 3262 init1: 3262 opt: 3262 Z-score: 1350.3 bits: 259.4 E(85289): 1.8e-68 Smith-Waterman score: 3262; 100.0% identity (100.0% similar) in 496 aa overlap (1-496:7-502) 10 20 30 40 50 pF1KB8 MDRMKKIKRQLSMTLRGGRGIDKTNGAPEQIGLDESGGGGGSDPGEAPTRAAPG :::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_148 MQSEIAMDRMKKIKRQLSMTLRGGRGIDKTNGAPEQIGLDESGGGGGSDPGEAPTRAAPG 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB8 ELRSARGPLSSAPEIVHEDLKMGSDGESDQASATSSDEVQSPVRVRMRNHPPRKISTEDI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_148 ELRSARGPLSSAPEIVHEDLKMGSDGESDQASATSSDEVQSPVRVRMRNHPPRKISTEDI 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB8 NKRLSLPADIRLPEGYLEKLTLNSPIFDKPLSRRLRRVSLSEIGFGKLETYIKLDKLGEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_148 NKRLSLPADIRLPEGYLEKLTLNSPIFDKPLSRRLRRVSLSEIGFGKLETYIKLDKLGEG 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB8 TYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_148 TYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTEK 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB8 SLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_148 SLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLI 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB8 NERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_148 NERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYE 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB8 MATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYNYPKYRAEALLSHAPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_148 MATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYNYPKYRAEALLSHAPR 370 380 390 400 410 420 420 430 440 450 460 470 pF1KB8 LDSDGADLLTKLLQFEGRNRISAEDAMKHPFFLSLGERIHKLPDTTSIFALKEIQLQKEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_148 LDSDGADLLTKLLQFEGRNRISAEDAMKHPFFLSLGERIHKLPDTTSIFALKEIQLQKEA 430 440 450 460 470 480 480 490 pF1KB8 SLRSSSMPDSGRPAFRVVDTEF :::::::::::::::::::::: NP_148 SLRSSSMPDSGRPAFRVVDTEF 490 500 >>XP_016885058 (OMIM: 311550) PREDICTED: cyclin-dependen (543 aa) initn: 3262 init1: 3262 opt: 3262 Z-score: 1349.9 bits: 259.4 E(85289): 1.9e-68 Smith-Waterman score: 3262; 100.0% identity (100.0% similar) in 496 aa overlap (1-496:48-543) 10 20 30 pF1KB8 MDRMKKIKRQLSMTLRGGRGIDKTNGAPEQ :::::::::::::::::::::::::::::: XP_016 SHYSRSSGYSRDLNTEIYPGGADLLVVAIAMDRMKKIKRQLSMTLRGGRGIDKTNGAPEQ 20 30 40 50 60 70 40 50 60 70 80 90 pF1KB8 IGLDESGGGGGSDPGEAPTRAAPGELRSARGPLSSAPEIVHEDLKMGSDGESDQASATSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IGLDESGGGGGSDPGEAPTRAAPGELRSARGPLSSAPEIVHEDLKMGSDGESDQASATSS 80 90 100 110 120 130 100 110 120 130 140 150 pF1KB8 DEVQSPVRVRMRNHPPRKISTEDINKRLSLPADIRLPEGYLEKLTLNSPIFDKPLSRRLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DEVQSPVRVRMRNHPPRKISTEDINKRLSLPADIRLPEGYLEKLTLNSPIFDKPLSRRLR 140 150 160 170 180 190 160 170 180 190 200 210 pF1KB8 RVSLSEIGFGKLETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RVSLSEIGFGKLETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIR 200 210 220 230 240 250 220 230 240 250 260 270 pF1KB8 EVSLLKDLKHANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EVSLLKDLKHANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQL 260 270 280 290 300 310 280 290 300 310 320 330 pF1KB8 LRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPP 320 330 340 350 360 370 340 350 360 370 380 390 pF1KB8 DILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGIL 380 390 400 410 420 430 400 410 420 430 440 450 pF1KB8 SNEEFKTYNYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFFLSLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SNEEFKTYNYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFFLSLG 440 450 460 470 480 490 460 470 480 490 pF1KB8 ERIHKLPDTTSIFALKEIQLQKEASLRSSSMPDSGRPAFRVVDTEF :::::::::::::::::::::::::::::::::::::::::::::: XP_016 ERIHKLPDTTSIFALKEIQLQKEASLRSSSMPDSGRPAFRVVDTEF 500 510 520 530 540 >>NP_001163931 (OMIM: 311550) cyclin-dependent kinase 16 (570 aa) initn: 3262 init1: 3262 opt: 3262 Z-score: 1349.6 bits: 259.4 E(85289): 2e-68 Smith-Waterman score: 3262; 100.0% identity (100.0% similar) in 496 aa overlap (1-496:75-570) 10 20 30 pF1KB8 MDRMKKIKRQLSMTLRGGRGIDKTNGAPEQ :::::::::::::::::::::::::::::: NP_001 CSGAFPLDPNNPSLGPLPSISHLNLRTQIAMDRMKKIKRQLSMTLRGGRGIDKTNGAPEQ 50 60 70 80 90 100 40 50 60 70 80 90 pF1KB8 IGLDESGGGGGSDPGEAPTRAAPGELRSARGPLSSAPEIVHEDLKMGSDGESDQASATSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IGLDESGGGGGSDPGEAPTRAAPGELRSARGPLSSAPEIVHEDLKMGSDGESDQASATSS 110 120 130 140 150 160 100 110 120 130 140 150 pF1KB8 DEVQSPVRVRMRNHPPRKISTEDINKRLSLPADIRLPEGYLEKLTLNSPIFDKPLSRRLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DEVQSPVRVRMRNHPPRKISTEDINKRLSLPADIRLPEGYLEKLTLNSPIFDKPLSRRLR 170 180 190 200 210 220 160 170 180 190 200 210 pF1KB8 RVSLSEIGFGKLETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RVSLSEIGFGKLETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIR 230 240 250 260 270 280 220 230 240 250 260 270 pF1KB8 EVSLLKDLKHANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EVSLLKDLKHANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQL 290 300 310 320 330 340 280 290 300 310 320 330 pF1KB8 LRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPP 350 360 370 380 390 400 340 350 360 370 380 390 pF1KB8 DILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGIL 410 420 430 440 450 460 400 410 420 430 440 450 pF1KB8 SNEEFKTYNYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFFLSLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SNEEFKTYNYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFFLSLG 470 480 490 500 510 520 460 470 480 490 pF1KB8 ERIHKLPDTTSIFALKEIQLQKEASLRSSSMPDSGRPAFRVVDTEF :::::::::::::::::::::::::::::::::::::::::::::: NP_001 ERIHKLPDTTSIFALKEIQLQKEASLRSSSMPDSGRPAFRVVDTEF 530 540 550 560 570 >>XP_011542229 (OMIM: 311550) PREDICTED: cyclin-dependen (497 aa) initn: 3180 init1: 3180 opt: 3180 Z-score: 1317.3 bits: 253.2 E(85289): 1.2e-66 Smith-Waterman score: 3180; 100.0% identity (100.0% similar) in 484 aa overlap (1-484:1-484) 10 20 30 40 50 60 pF1KB8 MDRMKKIKRQLSMTLRGGRGIDKTNGAPEQIGLDESGGGGGSDPGEAPTRAAPGELRSAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MDRMKKIKRQLSMTLRGGRGIDKTNGAPEQIGLDESGGGGGSDPGEAPTRAAPGELRSAR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 GPLSSAPEIVHEDLKMGSDGESDQASATSSDEVQSPVRVRMRNHPPRKISTEDINKRLSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GPLSSAPEIVHEDLKMGSDGESDQASATSSDEVQSPVRVRMRNHPPRKISTEDINKRLSL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 PADIRLPEGYLEKLTLNSPIFDKPLSRRLRRVSLSEIGFGKLETYIKLDKLGEGTYATVY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PADIRLPEGYLEKLTLNSPIFDKPLSRRLRRVSLSEIGFGKLETYIKLDKLGEGTYATVY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 KGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTEKSLTLVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTEKSLTLVF 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 EYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGEL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 KLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 LFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYNYPKYRAEALLSHAPRLDSDGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYNYPKYRAEALLSHAPRLDSDGA 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB8 DLLTKLLQFEGRNRISAEDAMKHPFFLSLGERIHKLPDTTSIFALKEIQLQKEASLRSSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DLLTKLLQFEGRNRISAEDAMKHPFFLSLGERIHKLPDTTSIFALKEIQLQKEASLRSSS 430 440 450 460 470 480 490 pF1KB8 MPDSGRPAFRVVDTEF :::: XP_011 MPDSVAGGQHGRASLPH 490 >>XP_011542230 (OMIM: 311550) PREDICTED: cyclin-dependen (497 aa) initn: 3180 init1: 3180 opt: 3180 Z-score: 1317.3 bits: 253.2 E(85289): 1.2e-66 Smith-Waterman score: 3180; 100.0% identity (100.0% similar) in 484 aa overlap (1-484:1-484) 10 20 30 40 50 60 pF1KB8 MDRMKKIKRQLSMTLRGGRGIDKTNGAPEQIGLDESGGGGGSDPGEAPTRAAPGELRSAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MDRMKKIKRQLSMTLRGGRGIDKTNGAPEQIGLDESGGGGGSDPGEAPTRAAPGELRSAR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 GPLSSAPEIVHEDLKMGSDGESDQASATSSDEVQSPVRVRMRNHPPRKISTEDINKRLSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GPLSSAPEIVHEDLKMGSDGESDQASATSSDEVQSPVRVRMRNHPPRKISTEDINKRLSL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 PADIRLPEGYLEKLTLNSPIFDKPLSRRLRRVSLSEIGFGKLETYIKLDKLGEGTYATVY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PADIRLPEGYLEKLTLNSPIFDKPLSRRLRRVSLSEIGFGKLETYIKLDKLGEGTYATVY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 KGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTEKSLTLVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTEKSLTLVF 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 EYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGEL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 KLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 LFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYNYPKYRAEALLSHAPRLDSDGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYNYPKYRAEALLSHAPRLDSDGA 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB8 DLLTKLLQFEGRNRISAEDAMKHPFFLSLGERIHKLPDTTSIFALKEIQLQKEASLRSSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DLLTKLLQFEGRNRISAEDAMKHPFFLSLGERIHKLPDTTSIFALKEIQLQKEASLRSSS 430 440 450 460 470 480 490 pF1KB8 MPDSGRPAFRVVDTEF :::: XP_011 MPDSVAGGQHGRASLPH 490 496 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 10:09:52 2016 done: Fri Nov 4 10:09:54 2016 Total Scan time: 8.650 Total Display time: 0.070 Function used was FASTA [36.3.4 Apr, 2011]