FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8172, 140 aa 1>>>pF1KB8172 140 - 140 aa - 140 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.4203+/-0.000346; mu= 11.5948+/- 0.022 mean_var=69.0128+/-14.005, 0's: 0 Z-trim(114.1): 28 B-trim: 251 in 1/51 Lambda= 0.154387 statistics sampled from 23683 (23711) to 23683 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.655), E-opt: 0.2 (0.278), width: 16 Scan time: 4.060 The best scores are: opt bits E(85289) NP_000336 (OMIM: 127750,163890,168601,605543) alph ( 140) 879 204.2 5.8e-53 NP_001139527 (OMIM: 127750,163890,168601,605543) a ( 140) 879 204.2 5.8e-53 NP_001139526 (OMIM: 127750,163890,168601,605543) a ( 140) 879 204.2 5.8e-53 XP_016864052 (OMIM: 127750,163890,168601,605543) P ( 140) 879 204.2 5.8e-53 XP_011530510 (OMIM: 127750,163890,168601,605543) P ( 140) 879 204.2 5.8e-53 XP_016864051 (OMIM: 127750,163890,168601,605543) P ( 140) 879 204.2 5.8e-53 NP_009292 (OMIM: 127750,163890,168601,605543) alph ( 112) 612 144.6 3.8e-35 XP_011530506 (OMIM: 127750,163890,168601,605543) P ( 170) 612 144.7 5.4e-35 XP_011530509 (OMIM: 127750,163890,168601,605543) P ( 170) 612 144.7 5.4e-35 XP_011530508 (OMIM: 127750,163890,168601,605543) P ( 170) 612 144.7 5.4e-35 XP_011530505 (OMIM: 127750,163890,168601,605543) P ( 170) 612 144.7 5.4e-35 XP_011530507 (OMIM: 127750,163890,168601,605543) P ( 170) 612 144.7 5.4e-35 XP_006714979 (OMIM: 127750,602569) PREDICTED: beta ( 134) 459 110.6 8.1e-25 NP_003076 (OMIM: 127750,602569) beta-synuclein iso ( 134) 459 110.6 8.1e-25 NP_001001502 (OMIM: 127750,602569) beta-synuclein ( 134) 459 110.6 8.1e-25 XP_006714978 (OMIM: 127750,602569) PREDICTED: beta ( 152) 407 99.1 2.7e-21 XP_006714977 (OMIM: 127750,602569) PREDICTED: beta ( 152) 407 99.1 2.7e-21 XP_011532942 (OMIM: 127750,602569) PREDICTED: beta ( 152) 407 99.1 2.7e-21 NP_003078 (OMIM: 602998) gamma-synuclein isoform 1 ( 127) 388 94.8 4.4e-20 NP_001304966 (OMIM: 127750,602569) beta-synuclein ( 104) 383 93.6 8.1e-20 NP_001304964 (OMIM: 127750,602569) beta-synuclein ( 104) 383 93.6 8.1e-20 NP_001317049 (OMIM: 602998) gamma-synuclein isofor ( 126) 241 62.0 3.2e-10 NP_001304963 (OMIM: 127750,602569) beta-synuclein ( 120) 235 60.7 7.7e-10 NP_001304965 (OMIM: 127750,602569) beta-synuclein ( 120) 235 60.7 7.7e-10 >>NP_000336 (OMIM: 127750,163890,168601,605543) alpha-sy (140 aa) initn: 879 init1: 879 opt: 879 Z-score: 1071.9 bits: 204.2 E(85289): 5.8e-53 Smith-Waterman score: 879; 100.0% identity (100.0% similar) in 140 aa overlap (1-140:1-140) 10 20 30 40 50 60 pF1KB8 MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 EQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 EQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDP 70 80 90 100 110 120 130 140 pF1KB8 DNEAYEMPSEEGYQDYEPEA :::::::::::::::::::: NP_000 DNEAYEMPSEEGYQDYEPEA 130 140 >>NP_001139527 (OMIM: 127750,163890,168601,605543) alpha (140 aa) initn: 879 init1: 879 opt: 879 Z-score: 1071.9 bits: 204.2 E(85289): 5.8e-53 Smith-Waterman score: 879; 100.0% identity (100.0% similar) in 140 aa overlap (1-140:1-140) 10 20 30 40 50 60 pF1KB8 MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 EQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDP 70 80 90 100 110 120 130 140 pF1KB8 DNEAYEMPSEEGYQDYEPEA :::::::::::::::::::: NP_001 DNEAYEMPSEEGYQDYEPEA 130 140 >>NP_001139526 (OMIM: 127750,163890,168601,605543) alpha (140 aa) initn: 879 init1: 879 opt: 879 Z-score: 1071.9 bits: 204.2 E(85289): 5.8e-53 Smith-Waterman score: 879; 100.0% identity (100.0% similar) in 140 aa overlap (1-140:1-140) 10 20 30 40 50 60 pF1KB8 MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 EQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDP 70 80 90 100 110 120 130 140 pF1KB8 DNEAYEMPSEEGYQDYEPEA :::::::::::::::::::: NP_001 DNEAYEMPSEEGYQDYEPEA 130 140 >>XP_016864052 (OMIM: 127750,163890,168601,605543) PREDI (140 aa) initn: 879 init1: 879 opt: 879 Z-score: 1071.9 bits: 204.2 E(85289): 5.8e-53 Smith-Waterman score: 879; 100.0% identity (100.0% similar) in 140 aa overlap (1-140:1-140) 10 20 30 40 50 60 pF1KB8 MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 EQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDP 70 80 90 100 110 120 130 140 pF1KB8 DNEAYEMPSEEGYQDYEPEA :::::::::::::::::::: XP_016 DNEAYEMPSEEGYQDYEPEA 130 140 >>XP_011530510 (OMIM: 127750,163890,168601,605543) PREDI (140 aa) initn: 879 init1: 879 opt: 879 Z-score: 1071.9 bits: 204.2 E(85289): 5.8e-53 Smith-Waterman score: 879; 100.0% identity (100.0% similar) in 140 aa overlap (1-140:1-140) 10 20 30 40 50 60 pF1KB8 MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 EQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDP 70 80 90 100 110 120 130 140 pF1KB8 DNEAYEMPSEEGYQDYEPEA :::::::::::::::::::: XP_011 DNEAYEMPSEEGYQDYEPEA 130 140 >>XP_016864051 (OMIM: 127750,163890,168601,605543) PREDI (140 aa) initn: 879 init1: 879 opt: 879 Z-score: 1071.9 bits: 204.2 E(85289): 5.8e-53 Smith-Waterman score: 879; 100.0% identity (100.0% similar) in 140 aa overlap (1-140:1-140) 10 20 30 40 50 60 pF1KB8 MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 EQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDP 70 80 90 100 110 120 130 140 pF1KB8 DNEAYEMPSEEGYQDYEPEA :::::::::::::::::::: XP_016 DNEAYEMPSEEGYQDYEPEA 130 140 >>NP_009292 (OMIM: 127750,163890,168601,605543) alpha-sy (112 aa) initn: 612 init1: 612 opt: 612 Z-score: 751.9 bits: 144.6 E(85289): 3.8e-35 Smith-Waterman score: 618; 80.0% identity (80.0% similar) in 140 aa overlap (1-140:1-112) 10 20 30 40 50 60 pF1KB8 MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_009 MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 EQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDP :::::::::::::::::::::::::::::::::::::::::: NP_009 EQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGK------------------ 70 80 90 100 130 140 pF1KB8 DNEAYEMPSEEGYQDYEPEA :::::::::: NP_009 ----------EGYQDYEPEA 110 >>XP_011530506 (OMIM: 127750,163890,168601,605543) PREDI (170 aa) initn: 612 init1: 612 opt: 612 Z-score: 749.2 bits: 144.7 E(85289): 5.4e-35 Smith-Waterman score: 612; 100.0% identity (100.0% similar) in 102 aa overlap (1-102:1-102) 10 20 30 40 50 60 pF1KB8 MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 EQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDP :::::::::::::::::::::::::::::::::::::::::: XP_011 EQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKKHPKYKPSKRQENVVMFL 70 80 90 100 110 120 130 140 pF1KB8 DNEAYEMPSEEGYQDYEPEA XP_011 VQVKKICFPQVGKPFSFLRFFSSFFFQVKAFWRSQYPSLKVARSHVYICN 130 140 150 160 170 >>XP_011530509 (OMIM: 127750,163890,168601,605543) PREDI (170 aa) initn: 612 init1: 612 opt: 612 Z-score: 749.2 bits: 144.7 E(85289): 5.4e-35 Smith-Waterman score: 612; 100.0% identity (100.0% similar) in 102 aa overlap (1-102:1-102) 10 20 30 40 50 60 pF1KB8 MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 EQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDP :::::::::::::::::::::::::::::::::::::::::: XP_011 EQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKKHPKYKPSKRQENVVMFL 70 80 90 100 110 120 130 140 pF1KB8 DNEAYEMPSEEGYQDYEPEA XP_011 VQVKKICFPQVGKPFSFLRFFSSFFFQVKAFWRSQYPSLKVARSHVYICN 130 140 150 160 170 >>XP_011530508 (OMIM: 127750,163890,168601,605543) PREDI (170 aa) initn: 612 init1: 612 opt: 612 Z-score: 749.2 bits: 144.7 E(85289): 5.4e-35 Smith-Waterman score: 612; 100.0% identity (100.0% similar) in 102 aa overlap (1-102:1-102) 10 20 30 40 50 60 pF1KB8 MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 EQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDP :::::::::::::::::::::::::::::::::::::::::: XP_011 EQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKKHPKYKPSKRQENVVMFL 70 80 90 100 110 120 130 140 pF1KB8 DNEAYEMPSEEGYQDYEPEA XP_011 VQVKKICFPQVGKPFSFLRFFSSFFFQVKAFWRSQYPSLKVARSHVYICN 130 140 150 160 170 140 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 10:14:03 2016 done: Fri Nov 4 10:14:03 2016 Total Scan time: 4.060 Total Display time: -0.020 Function used was FASTA [36.3.4 Apr, 2011]