FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8174, 563 aa 1>>>pF1KB8174 563 - 563 aa - 563 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.6769+/-0.00101; mu= 3.7183+/- 0.061 mean_var=172.0862+/-34.641, 0's: 0 Z-trim(109.4): 25 B-trim: 0 in 0/53 Lambda= 0.097769 statistics sampled from 10844 (10861) to 10844 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.686), E-opt: 0.2 (0.334), width: 16 Scan time: 2.240 The best scores are: opt bits E(32554) CCDS328.1 GMEB1 gene_id:10691|Hs108|chr1 ( 563) 3613 522.0 7.4e-148 CCDS327.1 GMEB1 gene_id:10691|Hs108|chr1 ( 573) 3336 483.0 4.3e-136 CCDS13528.1 GMEB2 gene_id:26205|Hs108|chr20 ( 530) 695 110.4 5.5e-24 >>CCDS328.1 GMEB1 gene_id:10691|Hs108|chr1 (563 aa) initn: 3613 init1: 3613 opt: 3613 Z-score: 2768.0 bits: 522.0 E(32554): 7.4e-148 Smith-Waterman score: 3613; 100.0% identity (100.0% similar) in 563 aa overlap (1-563:1-563) 10 20 30 40 50 60 pF1KB8 MANAEVSVPVGDVVVVPTEGNEGENPEDTKTQVILQLQPVQQGIYEAGSENNTAVVAVET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS32 MANAEVSVPVGDVVVVPTEGNEGENPEDTKTQVILQLQPVQQGIYEAGSENNTAVVAVET 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 HTIHKIEEGIDTGTIEANEDMEIAYPITCGESKAILLWKKFVCPGINVKCVKFNDQLISP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS32 HTIHKIEEGIDTGTIEANEDMEIAYPITCGESKAILLWKKFVCPGINVKCVKFNDQLISP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 KHFVHLAGKSTLKDWKRAIRLGGIMLRKMMDSGQIDFYQHDKVCSNTCRSTKFDLLISSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS32 KHFVHLAGKSTLKDWKRAIRLGGIMLRKMMDSGQIDFYQHDKVCSNTCRSTKFDLLISSA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 RAPVPGQQTSVVQTPTSADGSITQIAISEESMEEAGLEWNSALTAAVTMATEEGVKKDSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS32 RAPVPGQQTSVVQTPTSADGSITQIAISEESMEEAGLEWNSALTAAVTMATEEGVKKDSE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 EISEDTLMFWKGIADVGLMEEVVCNIQKEIEELLRGVQQRLIQAPFQVTDAAVLNNVAHT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS32 EISEDTLMFWKGIADVGLMEEVVCNIQKEIEELLRGVQQRLIQAPFQVTDAAVLNNVAHT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 FGLMDTVKKVLDNRRNQVEQGEEQFLYTLTDLERQLEEQKKQGQDHRLKSQTVQNVVLMP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS32 FGLMDTVKKVLDNRRNQVEQGEEQFLYTLTDLERQLEEQKKQGQDHRLKSQTVQNVVLMP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 VSTPKPPKRPRLQRPASTTVLSPSPPVQQPQFTVISPITITPVGQSFSMGNIPVATLSQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS32 VSTPKPPKRPRLQRPASTTVLSPSPPVQQPQFTVISPITITPVGQSFSMGNIPVATLSQG 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB8 SSPVTVHTLPSGPQLFRYATVVSSAKSSSPDTVTIHPSSSLALLSSTAMQDGSTLGNMTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS32 SSPVTVHTLPSGPQLFRYATVVSSAKSSSPDTVTIHPSSSLALLSSTAMQDGSTLGNMTT 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB8 MVSPVELVAMESGLTSAIQAVESTSEDGQTIIEIDPAPDPEAEDTEGKAVILETELRTEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS32 MVSPVELVAMESGLTSAIQAVESTSEDGQTIIEIDPAPDPEAEDTEGKAVILETELRTEE 490 500 510 520 530 540 550 560 pF1KB8 KVVAEMEEHQHQVHNVEIVVLED ::::::::::::::::::::::: CCDS32 KVVAEMEEHQHQVHNVEIVVLED 550 560 >>CCDS327.1 GMEB1 gene_id:10691|Hs108|chr1 (573 aa) initn: 3336 init1: 3336 opt: 3336 Z-score: 2556.8 bits: 483.0 E(32554): 4.3e-136 Smith-Waterman score: 3583; 98.3% identity (98.3% similar) in 573 aa overlap (1-563:1-573) 10 20 30 40 50 pF1KB8 MANAEVSVPVGDVVVVPTEGNEGENPEDTKTQVILQLQPVQQG----------IYEAGSE ::::::::::::::::::::::::::::::::::::::::::: ::::::: CCDS32 MANAEVSVPVGDVVVVPTEGNEGENPEDTKTQVILQLQPVQQGLFIDGHFYNRIYEAGSE 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB8 NNTAVVAVETHTIHKIEEGIDTGTIEANEDMEIAYPITCGESKAILLWKKFVCPGINVKC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS32 NNTAVVAVETHTIHKIEEGIDTGTIEANEDMEIAYPITCGESKAILLWKKFVCPGINVKC 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB8 VKFNDQLISPKHFVHLAGKSTLKDWKRAIRLGGIMLRKMMDSGQIDFYQHDKVCSNTCRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS32 VKFNDQLISPKHFVHLAGKSTLKDWKRAIRLGGIMLRKMMDSGQIDFYQHDKVCSNTCRS 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB8 TKFDLLISSARAPVPGQQTSVVQTPTSADGSITQIAISEESMEEAGLEWNSALTAAVTMA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS32 TKFDLLISSARAPVPGQQTSVVQTPTSADGSITQIAISEESMEEAGLEWNSALTAAVTMA 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB8 TEEGVKKDSEEISEDTLMFWKGIADVGLMEEVVCNIQKEIEELLRGVQQRLIQAPFQVTD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS32 TEEGVKKDSEEISEDTLMFWKGIADVGLMEEVVCNIQKEIEELLRGVQQRLIQAPFQVTD 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB8 AAVLNNVAHTFGLMDTVKKVLDNRRNQVEQGEEQFLYTLTDLERQLEEQKKQGQDHRLKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS32 AAVLNNVAHTFGLMDTVKKVLDNRRNQVEQGEEQFLYTLTDLERQLEEQKKQGQDHRLKS 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB8 QTVQNVVLMPVSTPKPPKRPRLQRPASTTVLSPSPPVQQPQFTVISPITITPVGQSFSMG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS32 QTVQNVVLMPVSTPKPPKRPRLQRPASTTVLSPSPPVQQPQFTVISPITITPVGQSFSMG 370 380 390 400 410 420 420 430 440 450 460 470 pF1KB8 NIPVATLSQGSSPVTVHTLPSGPQLFRYATVVSSAKSSSPDTVTIHPSSSLALLSSTAMQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS32 NIPVATLSQGSSPVTVHTLPSGPQLFRYATVVSSAKSSSPDTVTIHPSSSLALLSSTAMQ 430 440 450 460 470 480 480 490 500 510 520 530 pF1KB8 DGSTLGNMTTMVSPVELVAMESGLTSAIQAVESTSEDGQTIIEIDPAPDPEAEDTEGKAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS32 DGSTLGNMTTMVSPVELVAMESGLTSAIQAVESTSEDGQTIIEIDPAPDPEAEDTEGKAV 490 500 510 520 530 540 540 550 560 pF1KB8 ILETELRTEEKVVAEMEEHQHQVHNVEIVVLED ::::::::::::::::::::::::::::::::: CCDS32 ILETELRTEEKVVAEMEEHQHQVHNVEIVVLED 550 560 570 >>CCDS13528.1 GMEB2 gene_id:26205|Hs108|chr20 (530 aa) initn: 1232 init1: 602 opt: 695 Z-score: 544.0 bits: 110.4 E(32554): 5.5e-24 Smith-Waterman score: 1254; 41.2% identity (70.5% similar) in 539 aa overlap (1-521:1-512) 10 20 30 40 50 pF1KB8 MANAEVSVPVGDVVVV--PTEGNEGENPEDTKTQVIL-QLQPVQQGIYEAG--SENNTAV ::. .::: . .:::: : . .: . : .:: .. .: : . : . .:: .:. CCDS13 MATPDVSVHMEEVVVVTTPDTAVDGSGVEGVKTVLVTTNLAPHGGDLTEDNMETENAAAA 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB8 VAVETHTIHKIEEGIDTGTIEANEDME--IAYPITCGESKAILLWKKFVCPGINVKCVKF .:. . ...:.. . : .:..: :.::::::.:.: :.:.::::::::::::.. CCDS13 AAAAFTASSQLKEAVLVKMAEEGENLEAEIVYPITCGDSRANLIWRKFVCPGINVKCVQY 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB8 NDQLISPKHFVHLAGKSTLKDWKRAIRLGGIMLRKMMDSGQIDFYQHDKVCSNTCRSTKF ....::::.::::::::::::::::::..::::::.::::..:::::::::::::::::. CCDS13 DEHVISPKEFVHLAGKSTLKDWKRAIRMNGIMLRKIMDSGELDFYQHDKVCSNTCRSTKI 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB8 DLLISSARAPV--PGQQTSVVQTPTSADGSITQIAISEESMEEAGLEWNSALTAAVTMAT :: :.::. . : . . ::..:: . . .:. :. :. : .:..: CCDS13 DL--SGARVSLSSPTSAEYIPLTPAAADVNGSPATITIETCEDPG-DWTAA--------- 190 200 210 220 240 250 260 270 280 290 pF1KB8 EEGVKKDSEEISEDTLMFWKGIADVGLMEEVVCNIQKEIEELLRGVQQRLIQAPFQVTDA :..::. ::.:. :.::..::. ....:. : .::.:::. . :.:. :: CCDS13 ----------IGDDTFTFWRGLKDAGLLDEVIQEFHQELVETMRGLQQRVQDPPLQLRDA 230 240 250 260 270 300 310 320 330 340 350 pF1KB8 AVLNNVAHTFGLMDTVKKVLDNRRNQVEQGEEQFLYTLTDLERQLEEQKKQGQDHRLKSQ ..:::....::..: ::::: ... :.....::. :. ::.: .:....... . ::: CCDS13 VLLNNIVQNFGMLDLVKKVLASHKCQMDRSREQYARDLAALEQQCDEHRRRAKELKHKSQ 280 290 300 310 320 330 360 370 380 390 400 pF1KB8 TVQNVV--LMPVSTPKPPKRPRLQRPASTTVLSPSPPVQQPQFTVISPITITPVGQSFSM ..::. : ::: : : ::::: : .: . : . : ...: . .: : . CCDS13 HLSNVLMTLTPVSLPPPVKRPRLARATSGPAAMASQVLTQSAQLALGPGVPVPQLTSVPL 340 350 360 370 380 390 410 420 430 440 450 460 pF1KB8 GNI----PVATLSQGSSPVTVHTLPSGPQLFRYATVVSSAKSSSPDTVTIHP-SSSLALL :.. : ..:..:: . . :..: : : ::..:. :. :.:: ::: .:::..: CCDS13 GKVVSTLPSTVLGKGSLQAPPASSPASPLLGGY-TVLASSGSTYPSTVEIHPDASSLTVL 400 410 420 430 440 450 470 480 490 500 510 520 pF1KB8 SSTAMQDGSTLGNMTTMVSPVELVAMESGLTSAIQAVESTSEDGQTIIEIDP--APDPEA :..:.:::::. .:::..:... :: ..: : ..: ..::. . :: :: CCDS13 STAAVQDGSTV---FKVVSPLQLLTLP-GLGPTLQNVAQASPGSSTIVTVPAGAAPGPEE 460 470 480 490 500 510 530 540 550 560 pF1KB8 EDTEGKAVILETELRTEEKVVAEMEEHQHQVHNVEIVVLED CCDS13 HTATIEVAAMAEDHERK 520 530 563 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 10:15:13 2016 done: Fri Nov 4 10:15:13 2016 Total Scan time: 2.240 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]