FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8174, 563 aa 1>>>pF1KB8174 563 - 563 aa - 563 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 9.3342+/-0.000417; mu= 0.0237+/- 0.026 mean_var=201.6644+/-41.821, 0's: 0 Z-trim(117.4): 61 B-trim: 0 in 0/59 Lambda= 0.090315 statistics sampled from 29235 (29296) to 29235 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.694), E-opt: 0.2 (0.343), width: 16 Scan time: 9.350 The best scores are: opt bits E(85289) NP_077808 (OMIM: 604409) glucocorticoid modulatory ( 563) 3613 483.7 6.6e-136 XP_011538823 (OMIM: 604409) PREDICTED: glucocortic ( 563) 3613 483.7 6.6e-136 NP_001306603 (OMIM: 604409) glucocorticoid modulat ( 563) 3613 483.7 6.6e-136 XP_016855576 (OMIM: 604409) PREDICTED: glucocortic ( 573) 3336 447.6 4.9e-125 XP_011538820 (OMIM: 604409) PREDICTED: glucocortic ( 573) 3336 447.6 4.9e-125 NP_006573 (OMIM: 604409) glucocorticoid modulatory ( 573) 3336 447.6 4.9e-125 XP_011538821 (OMIM: 604409) PREDICTED: glucocortic ( 573) 3336 447.6 4.9e-125 XP_011538824 (OMIM: 604409) PREDICTED: glucocortic ( 367) 2296 312.0 2.1e-84 XP_005260259 (OMIM: 607451) PREDICTED: glucocortic ( 530) 695 103.5 1.8e-21 NP_036516 (OMIM: 607451) glucocorticoid modulatory ( 530) 695 103.5 1.8e-21 XP_006723839 (OMIM: 607451) PREDICTED: glucocortic ( 452) 633 95.4 4.2e-19 XP_011527081 (OMIM: 607451) PREDICTED: glucocortic ( 452) 633 95.4 4.2e-19 >>NP_077808 (OMIM: 604409) glucocorticoid modulatory ele (563 aa) initn: 3613 init1: 3613 opt: 3613 Z-score: 2560.9 bits: 483.7 E(85289): 6.6e-136 Smith-Waterman score: 3613; 100.0% identity (100.0% similar) in 563 aa overlap (1-563:1-563) 10 20 30 40 50 60 pF1KB8 MANAEVSVPVGDVVVVPTEGNEGENPEDTKTQVILQLQPVQQGIYEAGSENNTAVVAVET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_077 MANAEVSVPVGDVVVVPTEGNEGENPEDTKTQVILQLQPVQQGIYEAGSENNTAVVAVET 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 HTIHKIEEGIDTGTIEANEDMEIAYPITCGESKAILLWKKFVCPGINVKCVKFNDQLISP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_077 HTIHKIEEGIDTGTIEANEDMEIAYPITCGESKAILLWKKFVCPGINVKCVKFNDQLISP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 KHFVHLAGKSTLKDWKRAIRLGGIMLRKMMDSGQIDFYQHDKVCSNTCRSTKFDLLISSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_077 KHFVHLAGKSTLKDWKRAIRLGGIMLRKMMDSGQIDFYQHDKVCSNTCRSTKFDLLISSA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 RAPVPGQQTSVVQTPTSADGSITQIAISEESMEEAGLEWNSALTAAVTMATEEGVKKDSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_077 RAPVPGQQTSVVQTPTSADGSITQIAISEESMEEAGLEWNSALTAAVTMATEEGVKKDSE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 EISEDTLMFWKGIADVGLMEEVVCNIQKEIEELLRGVQQRLIQAPFQVTDAAVLNNVAHT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_077 EISEDTLMFWKGIADVGLMEEVVCNIQKEIEELLRGVQQRLIQAPFQVTDAAVLNNVAHT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 FGLMDTVKKVLDNRRNQVEQGEEQFLYTLTDLERQLEEQKKQGQDHRLKSQTVQNVVLMP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_077 FGLMDTVKKVLDNRRNQVEQGEEQFLYTLTDLERQLEEQKKQGQDHRLKSQTVQNVVLMP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 VSTPKPPKRPRLQRPASTTVLSPSPPVQQPQFTVISPITITPVGQSFSMGNIPVATLSQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_077 VSTPKPPKRPRLQRPASTTVLSPSPPVQQPQFTVISPITITPVGQSFSMGNIPVATLSQG 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB8 SSPVTVHTLPSGPQLFRYATVVSSAKSSSPDTVTIHPSSSLALLSSTAMQDGSTLGNMTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_077 SSPVTVHTLPSGPQLFRYATVVSSAKSSSPDTVTIHPSSSLALLSSTAMQDGSTLGNMTT 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB8 MVSPVELVAMESGLTSAIQAVESTSEDGQTIIEIDPAPDPEAEDTEGKAVILETELRTEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_077 MVSPVELVAMESGLTSAIQAVESTSEDGQTIIEIDPAPDPEAEDTEGKAVILETELRTEE 490 500 510 520 530 540 550 560 pF1KB8 KVVAEMEEHQHQVHNVEIVVLED ::::::::::::::::::::::: NP_077 KVVAEMEEHQHQVHNVEIVVLED 550 560 >>XP_011538823 (OMIM: 604409) PREDICTED: glucocorticoid (563 aa) initn: 3613 init1: 3613 opt: 3613 Z-score: 2560.9 bits: 483.7 E(85289): 6.6e-136 Smith-Waterman score: 3613; 100.0% identity (100.0% similar) in 563 aa overlap (1-563:1-563) 10 20 30 40 50 60 pF1KB8 MANAEVSVPVGDVVVVPTEGNEGENPEDTKTQVILQLQPVQQGIYEAGSENNTAVVAVET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MANAEVSVPVGDVVVVPTEGNEGENPEDTKTQVILQLQPVQQGIYEAGSENNTAVVAVET 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 HTIHKIEEGIDTGTIEANEDMEIAYPITCGESKAILLWKKFVCPGINVKCVKFNDQLISP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HTIHKIEEGIDTGTIEANEDMEIAYPITCGESKAILLWKKFVCPGINVKCVKFNDQLISP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 KHFVHLAGKSTLKDWKRAIRLGGIMLRKMMDSGQIDFYQHDKVCSNTCRSTKFDLLISSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KHFVHLAGKSTLKDWKRAIRLGGIMLRKMMDSGQIDFYQHDKVCSNTCRSTKFDLLISSA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 RAPVPGQQTSVVQTPTSADGSITQIAISEESMEEAGLEWNSALTAAVTMATEEGVKKDSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RAPVPGQQTSVVQTPTSADGSITQIAISEESMEEAGLEWNSALTAAVTMATEEGVKKDSE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 EISEDTLMFWKGIADVGLMEEVVCNIQKEIEELLRGVQQRLIQAPFQVTDAAVLNNVAHT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EISEDTLMFWKGIADVGLMEEVVCNIQKEIEELLRGVQQRLIQAPFQVTDAAVLNNVAHT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 FGLMDTVKKVLDNRRNQVEQGEEQFLYTLTDLERQLEEQKKQGQDHRLKSQTVQNVVLMP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FGLMDTVKKVLDNRRNQVEQGEEQFLYTLTDLERQLEEQKKQGQDHRLKSQTVQNVVLMP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 VSTPKPPKRPRLQRPASTTVLSPSPPVQQPQFTVISPITITPVGQSFSMGNIPVATLSQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VSTPKPPKRPRLQRPASTTVLSPSPPVQQPQFTVISPITITPVGQSFSMGNIPVATLSQG 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB8 SSPVTVHTLPSGPQLFRYATVVSSAKSSSPDTVTIHPSSSLALLSSTAMQDGSTLGNMTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SSPVTVHTLPSGPQLFRYATVVSSAKSSSPDTVTIHPSSSLALLSSTAMQDGSTLGNMTT 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB8 MVSPVELVAMESGLTSAIQAVESTSEDGQTIIEIDPAPDPEAEDTEGKAVILETELRTEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MVSPVELVAMESGLTSAIQAVESTSEDGQTIIEIDPAPDPEAEDTEGKAVILETELRTEE 490 500 510 520 530 540 550 560 pF1KB8 KVVAEMEEHQHQVHNVEIVVLED ::::::::::::::::::::::: XP_011 KVVAEMEEHQHQVHNVEIVVLED 550 560 >>NP_001306603 (OMIM: 604409) glucocorticoid modulatory (563 aa) initn: 3613 init1: 3613 opt: 3613 Z-score: 2560.9 bits: 483.7 E(85289): 6.6e-136 Smith-Waterman score: 3613; 100.0% identity (100.0% similar) in 563 aa overlap (1-563:1-563) 10 20 30 40 50 60 pF1KB8 MANAEVSVPVGDVVVVPTEGNEGENPEDTKTQVILQLQPVQQGIYEAGSENNTAVVAVET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MANAEVSVPVGDVVVVPTEGNEGENPEDTKTQVILQLQPVQQGIYEAGSENNTAVVAVET 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 HTIHKIEEGIDTGTIEANEDMEIAYPITCGESKAILLWKKFVCPGINVKCVKFNDQLISP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HTIHKIEEGIDTGTIEANEDMEIAYPITCGESKAILLWKKFVCPGINVKCVKFNDQLISP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 KHFVHLAGKSTLKDWKRAIRLGGIMLRKMMDSGQIDFYQHDKVCSNTCRSTKFDLLISSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KHFVHLAGKSTLKDWKRAIRLGGIMLRKMMDSGQIDFYQHDKVCSNTCRSTKFDLLISSA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 RAPVPGQQTSVVQTPTSADGSITQIAISEESMEEAGLEWNSALTAAVTMATEEGVKKDSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RAPVPGQQTSVVQTPTSADGSITQIAISEESMEEAGLEWNSALTAAVTMATEEGVKKDSE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 EISEDTLMFWKGIADVGLMEEVVCNIQKEIEELLRGVQQRLIQAPFQVTDAAVLNNVAHT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EISEDTLMFWKGIADVGLMEEVVCNIQKEIEELLRGVQQRLIQAPFQVTDAAVLNNVAHT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 FGLMDTVKKVLDNRRNQVEQGEEQFLYTLTDLERQLEEQKKQGQDHRLKSQTVQNVVLMP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FGLMDTVKKVLDNRRNQVEQGEEQFLYTLTDLERQLEEQKKQGQDHRLKSQTVQNVVLMP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 VSTPKPPKRPRLQRPASTTVLSPSPPVQQPQFTVISPITITPVGQSFSMGNIPVATLSQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VSTPKPPKRPRLQRPASTTVLSPSPPVQQPQFTVISPITITPVGQSFSMGNIPVATLSQG 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB8 SSPVTVHTLPSGPQLFRYATVVSSAKSSSPDTVTIHPSSSLALLSSTAMQDGSTLGNMTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SSPVTVHTLPSGPQLFRYATVVSSAKSSSPDTVTIHPSSSLALLSSTAMQDGSTLGNMTT 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB8 MVSPVELVAMESGLTSAIQAVESTSEDGQTIIEIDPAPDPEAEDTEGKAVILETELRTEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MVSPVELVAMESGLTSAIQAVESTSEDGQTIIEIDPAPDPEAEDTEGKAVILETELRTEE 490 500 510 520 530 540 550 560 pF1KB8 KVVAEMEEHQHQVHNVEIVVLED ::::::::::::::::::::::: NP_001 KVVAEMEEHQHQVHNVEIVVLED 550 560 >>XP_016855576 (OMIM: 604409) PREDICTED: glucocorticoid (573 aa) initn: 3336 init1: 3336 opt: 3336 Z-score: 2365.7 bits: 447.6 E(85289): 4.9e-125 Smith-Waterman score: 3583; 98.3% identity (98.3% similar) in 573 aa overlap (1-563:1-573) 10 20 30 40 50 pF1KB8 MANAEVSVPVGDVVVVPTEGNEGENPEDTKTQVILQLQPVQQG----------IYEAGSE ::::::::::::::::::::::::::::::::::::::::::: ::::::: XP_016 MANAEVSVPVGDVVVVPTEGNEGENPEDTKTQVILQLQPVQQGLFIDGHFYNRIYEAGSE 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB8 NNTAVVAVETHTIHKIEEGIDTGTIEANEDMEIAYPITCGESKAILLWKKFVCPGINVKC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NNTAVVAVETHTIHKIEEGIDTGTIEANEDMEIAYPITCGESKAILLWKKFVCPGINVKC 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB8 VKFNDQLISPKHFVHLAGKSTLKDWKRAIRLGGIMLRKMMDSGQIDFYQHDKVCSNTCRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VKFNDQLISPKHFVHLAGKSTLKDWKRAIRLGGIMLRKMMDSGQIDFYQHDKVCSNTCRS 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB8 TKFDLLISSARAPVPGQQTSVVQTPTSADGSITQIAISEESMEEAGLEWNSALTAAVTMA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TKFDLLISSARAPVPGQQTSVVQTPTSADGSITQIAISEESMEEAGLEWNSALTAAVTMA 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB8 TEEGVKKDSEEISEDTLMFWKGIADVGLMEEVVCNIQKEIEELLRGVQQRLIQAPFQVTD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TEEGVKKDSEEISEDTLMFWKGIADVGLMEEVVCNIQKEIEELLRGVQQRLIQAPFQVTD 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB8 AAVLNNVAHTFGLMDTVKKVLDNRRNQVEQGEEQFLYTLTDLERQLEEQKKQGQDHRLKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AAVLNNVAHTFGLMDTVKKVLDNRRNQVEQGEEQFLYTLTDLERQLEEQKKQGQDHRLKS 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB8 QTVQNVVLMPVSTPKPPKRPRLQRPASTTVLSPSPPVQQPQFTVISPITITPVGQSFSMG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QTVQNVVLMPVSTPKPPKRPRLQRPASTTVLSPSPPVQQPQFTVISPITITPVGQSFSMG 370 380 390 400 410 420 420 430 440 450 460 470 pF1KB8 NIPVATLSQGSSPVTVHTLPSGPQLFRYATVVSSAKSSSPDTVTIHPSSSLALLSSTAMQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NIPVATLSQGSSPVTVHTLPSGPQLFRYATVVSSAKSSSPDTVTIHPSSSLALLSSTAMQ 430 440 450 460 470 480 480 490 500 510 520 530 pF1KB8 DGSTLGNMTTMVSPVELVAMESGLTSAIQAVESTSEDGQTIIEIDPAPDPEAEDTEGKAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DGSTLGNMTTMVSPVELVAMESGLTSAIQAVESTSEDGQTIIEIDPAPDPEAEDTEGKAV 490 500 510 520 530 540 540 550 560 pF1KB8 ILETELRTEEKVVAEMEEHQHQVHNVEIVVLED ::::::::::::::::::::::::::::::::: XP_016 ILETELRTEEKVVAEMEEHQHQVHNVEIVVLED 550 560 570 >>XP_011538820 (OMIM: 604409) PREDICTED: glucocorticoid (573 aa) initn: 3336 init1: 3336 opt: 3336 Z-score: 2365.7 bits: 447.6 E(85289): 4.9e-125 Smith-Waterman score: 3583; 98.3% identity (98.3% similar) in 573 aa overlap (1-563:1-573) 10 20 30 40 50 pF1KB8 MANAEVSVPVGDVVVVPTEGNEGENPEDTKTQVILQLQPVQQG----------IYEAGSE ::::::::::::::::::::::::::::::::::::::::::: ::::::: XP_011 MANAEVSVPVGDVVVVPTEGNEGENPEDTKTQVILQLQPVQQGLFIDGHFYNRIYEAGSE 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB8 NNTAVVAVETHTIHKIEEGIDTGTIEANEDMEIAYPITCGESKAILLWKKFVCPGINVKC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NNTAVVAVETHTIHKIEEGIDTGTIEANEDMEIAYPITCGESKAILLWKKFVCPGINVKC 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB8 VKFNDQLISPKHFVHLAGKSTLKDWKRAIRLGGIMLRKMMDSGQIDFYQHDKVCSNTCRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VKFNDQLISPKHFVHLAGKSTLKDWKRAIRLGGIMLRKMMDSGQIDFYQHDKVCSNTCRS 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB8 TKFDLLISSARAPVPGQQTSVVQTPTSADGSITQIAISEESMEEAGLEWNSALTAAVTMA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TKFDLLISSARAPVPGQQTSVVQTPTSADGSITQIAISEESMEEAGLEWNSALTAAVTMA 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB8 TEEGVKKDSEEISEDTLMFWKGIADVGLMEEVVCNIQKEIEELLRGVQQRLIQAPFQVTD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TEEGVKKDSEEISEDTLMFWKGIADVGLMEEVVCNIQKEIEELLRGVQQRLIQAPFQVTD 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB8 AAVLNNVAHTFGLMDTVKKVLDNRRNQVEQGEEQFLYTLTDLERQLEEQKKQGQDHRLKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AAVLNNVAHTFGLMDTVKKVLDNRRNQVEQGEEQFLYTLTDLERQLEEQKKQGQDHRLKS 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB8 QTVQNVVLMPVSTPKPPKRPRLQRPASTTVLSPSPPVQQPQFTVISPITITPVGQSFSMG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QTVQNVVLMPVSTPKPPKRPRLQRPASTTVLSPSPPVQQPQFTVISPITITPVGQSFSMG 370 380 390 400 410 420 420 430 440 450 460 470 pF1KB8 NIPVATLSQGSSPVTVHTLPSGPQLFRYATVVSSAKSSSPDTVTIHPSSSLALLSSTAMQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NIPVATLSQGSSPVTVHTLPSGPQLFRYATVVSSAKSSSPDTVTIHPSSSLALLSSTAMQ 430 440 450 460 470 480 480 490 500 510 520 530 pF1KB8 DGSTLGNMTTMVSPVELVAMESGLTSAIQAVESTSEDGQTIIEIDPAPDPEAEDTEGKAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DGSTLGNMTTMVSPVELVAMESGLTSAIQAVESTSEDGQTIIEIDPAPDPEAEDTEGKAV 490 500 510 520 530 540 540 550 560 pF1KB8 ILETELRTEEKVVAEMEEHQHQVHNVEIVVLED ::::::::::::::::::::::::::::::::: XP_011 ILETELRTEEKVVAEMEEHQHQVHNVEIVVLED 550 560 570 >>NP_006573 (OMIM: 604409) glucocorticoid modulatory ele (573 aa) initn: 3336 init1: 3336 opt: 3336 Z-score: 2365.7 bits: 447.6 E(85289): 4.9e-125 Smith-Waterman score: 3583; 98.3% identity (98.3% similar) in 573 aa overlap (1-563:1-573) 10 20 30 40 50 pF1KB8 MANAEVSVPVGDVVVVPTEGNEGENPEDTKTQVILQLQPVQQG----------IYEAGSE ::::::::::::::::::::::::::::::::::::::::::: ::::::: NP_006 MANAEVSVPVGDVVVVPTEGNEGENPEDTKTQVILQLQPVQQGLFIDGHFYNRIYEAGSE 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB8 NNTAVVAVETHTIHKIEEGIDTGTIEANEDMEIAYPITCGESKAILLWKKFVCPGINVKC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 NNTAVVAVETHTIHKIEEGIDTGTIEANEDMEIAYPITCGESKAILLWKKFVCPGINVKC 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB8 VKFNDQLISPKHFVHLAGKSTLKDWKRAIRLGGIMLRKMMDSGQIDFYQHDKVCSNTCRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 VKFNDQLISPKHFVHLAGKSTLKDWKRAIRLGGIMLRKMMDSGQIDFYQHDKVCSNTCRS 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB8 TKFDLLISSARAPVPGQQTSVVQTPTSADGSITQIAISEESMEEAGLEWNSALTAAVTMA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 TKFDLLISSARAPVPGQQTSVVQTPTSADGSITQIAISEESMEEAGLEWNSALTAAVTMA 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB8 TEEGVKKDSEEISEDTLMFWKGIADVGLMEEVVCNIQKEIEELLRGVQQRLIQAPFQVTD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 TEEGVKKDSEEISEDTLMFWKGIADVGLMEEVVCNIQKEIEELLRGVQQRLIQAPFQVTD 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB8 AAVLNNVAHTFGLMDTVKKVLDNRRNQVEQGEEQFLYTLTDLERQLEEQKKQGQDHRLKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 AAVLNNVAHTFGLMDTVKKVLDNRRNQVEQGEEQFLYTLTDLERQLEEQKKQGQDHRLKS 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB8 QTVQNVVLMPVSTPKPPKRPRLQRPASTTVLSPSPPVQQPQFTVISPITITPVGQSFSMG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 QTVQNVVLMPVSTPKPPKRPRLQRPASTTVLSPSPPVQQPQFTVISPITITPVGQSFSMG 370 380 390 400 410 420 420 430 440 450 460 470 pF1KB8 NIPVATLSQGSSPVTVHTLPSGPQLFRYATVVSSAKSSSPDTVTIHPSSSLALLSSTAMQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 NIPVATLSQGSSPVTVHTLPSGPQLFRYATVVSSAKSSSPDTVTIHPSSSLALLSSTAMQ 430 440 450 460 470 480 480 490 500 510 520 530 pF1KB8 DGSTLGNMTTMVSPVELVAMESGLTSAIQAVESTSEDGQTIIEIDPAPDPEAEDTEGKAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 DGSTLGNMTTMVSPVELVAMESGLTSAIQAVESTSEDGQTIIEIDPAPDPEAEDTEGKAV 490 500 510 520 530 540 540 550 560 pF1KB8 ILETELRTEEKVVAEMEEHQHQVHNVEIVVLED ::::::::::::::::::::::::::::::::: NP_006 ILETELRTEEKVVAEMEEHQHQVHNVEIVVLED 550 560 570 >>XP_011538821 (OMIM: 604409) PREDICTED: glucocorticoid (573 aa) initn: 3336 init1: 3336 opt: 3336 Z-score: 2365.7 bits: 447.6 E(85289): 4.9e-125 Smith-Waterman score: 3583; 98.3% identity (98.3% similar) in 573 aa overlap (1-563:1-573) 10 20 30 40 50 pF1KB8 MANAEVSVPVGDVVVVPTEGNEGENPEDTKTQVILQLQPVQQG----------IYEAGSE ::::::::::::::::::::::::::::::::::::::::::: ::::::: XP_011 MANAEVSVPVGDVVVVPTEGNEGENPEDTKTQVILQLQPVQQGLFIDGHFYNRIYEAGSE 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB8 NNTAVVAVETHTIHKIEEGIDTGTIEANEDMEIAYPITCGESKAILLWKKFVCPGINVKC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NNTAVVAVETHTIHKIEEGIDTGTIEANEDMEIAYPITCGESKAILLWKKFVCPGINVKC 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB8 VKFNDQLISPKHFVHLAGKSTLKDWKRAIRLGGIMLRKMMDSGQIDFYQHDKVCSNTCRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VKFNDQLISPKHFVHLAGKSTLKDWKRAIRLGGIMLRKMMDSGQIDFYQHDKVCSNTCRS 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB8 TKFDLLISSARAPVPGQQTSVVQTPTSADGSITQIAISEESMEEAGLEWNSALTAAVTMA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TKFDLLISSARAPVPGQQTSVVQTPTSADGSITQIAISEESMEEAGLEWNSALTAAVTMA 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB8 TEEGVKKDSEEISEDTLMFWKGIADVGLMEEVVCNIQKEIEELLRGVQQRLIQAPFQVTD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TEEGVKKDSEEISEDTLMFWKGIADVGLMEEVVCNIQKEIEELLRGVQQRLIQAPFQVTD 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB8 AAVLNNVAHTFGLMDTVKKVLDNRRNQVEQGEEQFLYTLTDLERQLEEQKKQGQDHRLKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AAVLNNVAHTFGLMDTVKKVLDNRRNQVEQGEEQFLYTLTDLERQLEEQKKQGQDHRLKS 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB8 QTVQNVVLMPVSTPKPPKRPRLQRPASTTVLSPSPPVQQPQFTVISPITITPVGQSFSMG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QTVQNVVLMPVSTPKPPKRPRLQRPASTTVLSPSPPVQQPQFTVISPITITPVGQSFSMG 370 380 390 400 410 420 420 430 440 450 460 470 pF1KB8 NIPVATLSQGSSPVTVHTLPSGPQLFRYATVVSSAKSSSPDTVTIHPSSSLALLSSTAMQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NIPVATLSQGSSPVTVHTLPSGPQLFRYATVVSSAKSSSPDTVTIHPSSSLALLSSTAMQ 430 440 450 460 470 480 480 490 500 510 520 530 pF1KB8 DGSTLGNMTTMVSPVELVAMESGLTSAIQAVESTSEDGQTIIEIDPAPDPEAEDTEGKAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DGSTLGNMTTMVSPVELVAMESGLTSAIQAVESTSEDGQTIIEIDPAPDPEAEDTEGKAV 490 500 510 520 530 540 540 550 560 pF1KB8 ILETELRTEEKVVAEMEEHQHQVHNVEIVVLED ::::::::::::::::::::::::::::::::: XP_011 ILETELRTEEKVVAEMEEHQHQVHNVEIVVLED 550 560 570 >>XP_011538824 (OMIM: 604409) PREDICTED: glucocorticoid (367 aa) initn: 2296 init1: 2296 opt: 2296 Z-score: 1636.3 bits: 312.0 E(85289): 2.1e-84 Smith-Waterman score: 2296; 100.0% identity (100.0% similar) in 364 aa overlap (200-563:4-367) 170 180 190 200 210 220 pF1KB8 STKFDLLISSARAPVPGQQTSVVQTPTSADGSITQIAISEESMEEAGLEWNSALTAAVTM :::::::::::::::::::::::::::::: XP_011 MVGGSITQIAISEESMEEAGLEWNSALTAAVTM 10 20 30 230 240 250 260 270 280 pF1KB8 ATEEGVKKDSEEISEDTLMFWKGIADVGLMEEVVCNIQKEIEELLRGVQQRLIQAPFQVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ATEEGVKKDSEEISEDTLMFWKGIADVGLMEEVVCNIQKEIEELLRGVQQRLIQAPFQVT 40 50 60 70 80 90 290 300 310 320 330 340 pF1KB8 DAAVLNNVAHTFGLMDTVKKVLDNRRNQVEQGEEQFLYTLTDLERQLEEQKKQGQDHRLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DAAVLNNVAHTFGLMDTVKKVLDNRRNQVEQGEEQFLYTLTDLERQLEEQKKQGQDHRLK 100 110 120 130 140 150 350 360 370 380 390 400 pF1KB8 SQTVQNVVLMPVSTPKPPKRPRLQRPASTTVLSPSPPVQQPQFTVISPITITPVGQSFSM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SQTVQNVVLMPVSTPKPPKRPRLQRPASTTVLSPSPPVQQPQFTVISPITITPVGQSFSM 160 170 180 190 200 210 410 420 430 440 450 460 pF1KB8 GNIPVATLSQGSSPVTVHTLPSGPQLFRYATVVSSAKSSSPDTVTIHPSSSLALLSSTAM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GNIPVATLSQGSSPVTVHTLPSGPQLFRYATVVSSAKSSSPDTVTIHPSSSLALLSSTAM 220 230 240 250 260 270 470 480 490 500 510 520 pF1KB8 QDGSTLGNMTTMVSPVELVAMESGLTSAIQAVESTSEDGQTIIEIDPAPDPEAEDTEGKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QDGSTLGNMTTMVSPVELVAMESGLTSAIQAVESTSEDGQTIIEIDPAPDPEAEDTEGKA 280 290 300 310 320 330 530 540 550 560 pF1KB8 VILETELRTEEKVVAEMEEHQHQVHNVEIVVLED :::::::::::::::::::::::::::::::::: XP_011 VILETELRTEEKVVAEMEEHQHQVHNVEIVVLED 340 350 360 >>XP_005260259 (OMIM: 607451) PREDICTED: glucocorticoid (530 aa) initn: 1232 init1: 602 opt: 695 Z-score: 506.5 bits: 103.5 E(85289): 1.8e-21 Smith-Waterman score: 1254; 41.2% identity (70.5% similar) in 539 aa overlap (1-521:1-512) 10 20 30 40 50 pF1KB8 MANAEVSVPVGDVVVV--PTEGNEGENPEDTKTQVIL-QLQPVQQGIYEAG--SENNTAV ::. .::: . .:::: : . .: . : .:: .. .: : . : . .:: .:. XP_005 MATPDVSVHMEEVVVVTTPDTAVDGSGVEGVKTVLVTTNLAPHGGDLTEDNMETENAAAA 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB8 VAVETHTIHKIEEGIDTGTIEANEDME--IAYPITCGESKAILLWKKFVCPGINVKCVKF .:. . ...:.. . : .:..: :.::::::.:.: :.:.::::::::::::.. XP_005 AAAAFTASSQLKEAVLVKMAEEGENLEAEIVYPITCGDSRANLIWRKFVCPGINVKCVQY 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB8 NDQLISPKHFVHLAGKSTLKDWKRAIRLGGIMLRKMMDSGQIDFYQHDKVCSNTCRSTKF ....::::.::::::::::::::::::..::::::.::::..:::::::::::::::::. XP_005 DEHVISPKEFVHLAGKSTLKDWKRAIRMNGIMLRKIMDSGELDFYQHDKVCSNTCRSTKI 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB8 DLLISSARAPV--PGQQTSVVQTPTSADGSITQIAISEESMEEAGLEWNSALTAAVTMAT :: :.::. . : . . ::..:: . . .:. :. :. : .:..: XP_005 DL--SGARVSLSSPTSAEYIPLTPAAADVNGSPATITIETCEDPG-DWTAA--------- 190 200 210 220 240 250 260 270 280 290 pF1KB8 EEGVKKDSEEISEDTLMFWKGIADVGLMEEVVCNIQKEIEELLRGVQQRLIQAPFQVTDA :..::. ::.:. :.::..::. ....:. : .::.:::. . :.:. :: XP_005 ----------IGDDTFTFWRGLKDAGLLDEVIQEFHQELVETMRGLQQRVQDPPLQLRDA 230 240 250 260 270 300 310 320 330 340 350 pF1KB8 AVLNNVAHTFGLMDTVKKVLDNRRNQVEQGEEQFLYTLTDLERQLEEQKKQGQDHRLKSQ ..:::....::..: ::::: ... :.....::. :. ::.: .:....... . ::: XP_005 VLLNNIVQNFGMLDLVKKVLASHKCQMDRSREQYARDLAALEQQCDEHRRRAKELKHKSQ 280 290 300 310 320 330 360 370 380 390 400 pF1KB8 TVQNVV--LMPVSTPKPPKRPRLQRPASTTVLSPSPPVQQPQFTVISPITITPVGQSFSM ..::. : ::: : : ::::: : .: . : . : ...: . .: : . XP_005 HLSNVLMTLTPVSLPPPVKRPRLARATSGPAAMASQVLTQSAQLALGPGVPVPQLTSVPL 340 350 360 370 380 390 410 420 430 440 450 460 pF1KB8 GNI----PVATLSQGSSPVTVHTLPSGPQLFRYATVVSSAKSSSPDTVTIHP-SSSLALL :.. : ..:..:: . . :..: : : ::..:. :. :.:: ::: .:::..: XP_005 GKVVSTLPSTVLGKGSLQAPPASSPASPLLGGY-TVLASSGSTYPSTVEIHPDASSLTVL 400 410 420 430 440 450 470 480 490 500 510 520 pF1KB8 SSTAMQDGSTLGNMTTMVSPVELVAMESGLTSAIQAVESTSEDGQTIIEIDP--APDPEA :..:.:::::. .:::..:... :: ..: : ..: ..::. . :: :: XP_005 STAAVQDGSTV---FKVVSPLQLLTLP-GLGPTLQNVAQASPGSSTIVTVPAGAAPGPEE 460 470 480 490 500 510 530 540 550 560 pF1KB8 EDTEGKAVILETELRTEEKVVAEMEEHQHQVHNVEIVVLED XP_005 HTATIEVAAMAEDHERK 520 530 >>NP_036516 (OMIM: 607451) glucocorticoid modulatory ele (530 aa) initn: 1232 init1: 602 opt: 695 Z-score: 506.5 bits: 103.5 E(85289): 1.8e-21 Smith-Waterman score: 1254; 41.2% identity (70.5% similar) in 539 aa overlap (1-521:1-512) 10 20 30 40 50 pF1KB8 MANAEVSVPVGDVVVV--PTEGNEGENPEDTKTQVIL-QLQPVQQGIYEAG--SENNTAV ::. .::: . .:::: : . .: . : .:: .. .: : . : . .:: .:. NP_036 MATPDVSVHMEEVVVVTTPDTAVDGSGVEGVKTVLVTTNLAPHGGDLTEDNMETENAAAA 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB8 VAVETHTIHKIEEGIDTGTIEANEDME--IAYPITCGESKAILLWKKFVCPGINVKCVKF .:. . ...:.. . : .:..: :.::::::.:.: :.:.::::::::::::.. NP_036 AAAAFTASSQLKEAVLVKMAEEGENLEAEIVYPITCGDSRANLIWRKFVCPGINVKCVQY 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB8 NDQLISPKHFVHLAGKSTLKDWKRAIRLGGIMLRKMMDSGQIDFYQHDKVCSNTCRSTKF ....::::.::::::::::::::::::..::::::.::::..:::::::::::::::::. NP_036 DEHVISPKEFVHLAGKSTLKDWKRAIRMNGIMLRKIMDSGELDFYQHDKVCSNTCRSTKI 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB8 DLLISSARAPV--PGQQTSVVQTPTSADGSITQIAISEESMEEAGLEWNSALTAAVTMAT :: :.::. . : . . ::..:: . . .:. :. :. : .:..: NP_036 DL--SGARVSLSSPTSAEYIPLTPAAADVNGSPATITIETCEDPG-DWTAA--------- 190 200 210 220 240 250 260 270 280 290 pF1KB8 EEGVKKDSEEISEDTLMFWKGIADVGLMEEVVCNIQKEIEELLRGVQQRLIQAPFQVTDA :..::. ::.:. :.::..::. ....:. : .::.:::. . :.:. :: NP_036 ----------IGDDTFTFWRGLKDAGLLDEVIQEFHQELVETMRGLQQRVQDPPLQLRDA 230 240 250 260 270 300 310 320 330 340 350 pF1KB8 AVLNNVAHTFGLMDTVKKVLDNRRNQVEQGEEQFLYTLTDLERQLEEQKKQGQDHRLKSQ ..:::....::..: ::::: ... :.....::. :. ::.: .:....... . ::: NP_036 VLLNNIVQNFGMLDLVKKVLASHKCQMDRSREQYARDLAALEQQCDEHRRRAKELKHKSQ 280 290 300 310 320 330 360 370 380 390 400 pF1KB8 TVQNVV--LMPVSTPKPPKRPRLQRPASTTVLSPSPPVQQPQFTVISPITITPVGQSFSM ..::. : ::: : : ::::: : .: . : . : ...: . .: : . NP_036 HLSNVLMTLTPVSLPPPVKRPRLARATSGPAAMASQVLTQSAQLALGPGVPVPQLTSVPL 340 350 360 370 380 390 410 420 430 440 450 460 pF1KB8 GNI----PVATLSQGSSPVTVHTLPSGPQLFRYATVVSSAKSSSPDTVTIHP-SSSLALL :.. : ..:..:: . . :..: : : ::..:. :. :.:: ::: .:::..: NP_036 GKVVSTLPSTVLGKGSLQAPPASSPASPLLGGY-TVLASSGSTYPSTVEIHPDASSLTVL 400 410 420 430 440 450 470 480 490 500 510 520 pF1KB8 SSTAMQDGSTLGNMTTMVSPVELVAMESGLTSAIQAVESTSEDGQTIIEIDP--APDPEA :..:.:::::. .:::..:... :: ..: : ..: ..::. . :: :: NP_036 STAAVQDGSTV---FKVVSPLQLLTLP-GLGPTLQNVAQASPGSSTIVTVPAGAAPGPEE 460 470 480 490 500 510 530 540 550 560 pF1KB8 EDTEGKAVILETELRTEEKVVAEMEEHQHQVHNVEIVVLED NP_036 HTATIEVAAMAEDHERK 520 530 563 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 10:15:14 2016 done: Fri Nov 4 10:15:15 2016 Total Scan time: 9.350 Total Display time: 0.100 Function used was FASTA [36.3.4 Apr, 2011]