FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8179, 434 aa 1>>>pF1KB8179 434 - 434 aa - 434 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.8905+/-0.000878; mu= 14.5515+/- 0.052 mean_var=76.3373+/-15.422, 0's: 0 Z-trim(106.9): 22 B-trim: 367 in 1/50 Lambda= 0.146793 statistics sampled from 9253 (9268) to 9253 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.67), E-opt: 0.2 (0.285), width: 16 Scan time: 2.910 The best scores are: opt bits E(32554) CCDS75382.1 RMND5B gene_id:64777|Hs108|chr5 ( 380) 2038 441.1 8.9e-124 CCDS4431.1 RMND5B gene_id:64777|Hs108|chr5 ( 393) 2038 441.1 9.2e-124 CCDS1991.1 RMND5A gene_id:64795|Hs108|chr2 ( 391) 1480 322.9 3.4e-88 CCDS77888.1 MAEA gene_id:10296|Hs108|chr4 ( 348) 283 69.4 6.3e-12 CCDS75090.1 MAEA gene_id:10296|Hs108|chr4 ( 395) 283 69.4 7e-12 CCDS33936.1 MAEA gene_id:10296|Hs108|chr4 ( 396) 283 69.4 7.1e-12 >>CCDS75382.1 RMND5B gene_id:64777|Hs108|chr5 (380 aa) initn: 2038 init1: 2038 opt: 2038 Z-score: 2335.7 bits: 441.1 E(32554): 8.9e-124 Smith-Waterman score: 2258; 89.4% identity (89.4% similar) in 388 aa overlap (47-434:34-380) 20 30 40 50 60 70 pF1KB8 KFLTYGQHCERSLEELLHYVGQLRAELASAALQGTPLSATLSLVMSQCCRKIKDTVQKLA :::::::::::::::::::::::::::::: CCDS75 CSLDLPGSSSPPSHLSLLRSWDHRRVPPCPALQGTPLSATLSLVMSQCCRKIKDTVQKLA 10 20 30 40 50 60 80 90 100 110 120 130 pF1KB8 SDHKDIHSSVSRVGKAIDRVSTWPAPGVGWEHPEAGMYKDSKESQQECPHHQALSLLLRQ ::::::::::::::::::: CCDS75 SDHKDIHSSVSRVGKAIDR----------------------------------------- 70 80 140 150 160 170 180 190 pF1KB8 NFDSEICGVVSDAVWDAREQQQQILQMAIVEHLYQQGMLSVAEELCQESTLNVDLDFKQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS75 NFDSEICGVVSDAVWDAREQQQQILQMAIVEHLYQQGMLSVAEELCQESTLNVDLDFKQP 90 100 110 120 130 140 200 210 220 230 240 250 pF1KB8 FLELNRILEALHEQDLGPALEWAVSHRQRLLELNSSLEFKLHRLHFIRLLAGGPAKQLEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS75 FLELNRILEALHEQDLGPALEWAVSHRQRLLELNSSLEFKLHRLHFIRLLAGGPAKQLEA 150 160 170 180 190 200 260 270 280 290 300 310 pF1KB8 LSYARHFQPFARLHQREIQVMMGSLVYLRLGLEKSPYCHLLDSSHWAEICETFTRDACSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS75 LSYARHFQPFARLHQREIQVMMGSLVYLRLGLEKSPYCHLLDSSHWAEICETFTRDACSL 210 220 230 240 250 260 320 330 340 350 360 370 pF1KB8 LGLSVESPLSVSFASGCVALPVLMNIKAVIEQRQCTGVWNHKDELPIEIELGMKCWYHSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS75 LGLSVESPLSVSFASGCVALPVLMNIKAVIEQRQCTGVWNHKDELPIEIELGMKCWYHSV 270 280 290 300 310 320 380 390 400 410 420 430 pF1KB8 FACPILRQQTSDSNPPIKLICGHVISRDALNKLINGGKLKCPYCPMEQNPADGKRIIF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS75 FACPILRQQTSDSNPPIKLICGHVISRDALNKLINGGKLKCPYCPMEQNPADGKRIIF 330 340 350 360 370 380 >>CCDS4431.1 RMND5B gene_id:64777|Hs108|chr5 (393 aa) initn: 2038 init1: 2038 opt: 2038 Z-score: 2335.4 bits: 441.1 E(32554): 9.2e-124 Smith-Waterman score: 2565; 90.6% identity (90.6% similar) in 434 aa overlap (1-434:1-393) 10 20 30 40 50 60 pF1KB8 MEQCACVERELDKVLQKFLTYGQHCERSLEELLHYVGQLRAELASAALQGTPLSATLSLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 MEQCACVERELDKVLQKFLTYGQHCERSLEELLHYVGQLRAELASAALQGTPLSATLSLV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 MSQCCRKIKDTVQKLASDHKDIHSSVSRVGKAIDRVSTWPAPGVGWEHPEAGMYKDSKES ::::::::::::::::::::::::::::::::::: CCDS44 MSQCCRKIKDTVQKLASDHKDIHSSVSRVGKAIDR------------------------- 70 80 90 130 140 150 160 170 180 pF1KB8 QQECPHHQALSLLLRQNFDSEICGVVSDAVWDAREQQQQILQMAIVEHLYQQGMLSVAEE :::::::::::::::::::::::::::::::::::::::::::: CCDS44 ----------------NFDSEICGVVSDAVWDAREQQQQILQMAIVEHLYQQGMLSVAEE 100 110 120 130 190 200 210 220 230 240 pF1KB8 LCQESTLNVDLDFKQPFLELNRILEALHEQDLGPALEWAVSHRQRLLELNSSLEFKLHRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 LCQESTLNVDLDFKQPFLELNRILEALHEQDLGPALEWAVSHRQRLLELNSSLEFKLHRL 140 150 160 170 180 190 250 260 270 280 290 300 pF1KB8 HFIRLLAGGPAKQLEALSYARHFQPFARLHQREIQVMMGSLVYLRLGLEKSPYCHLLDSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 HFIRLLAGGPAKQLEALSYARHFQPFARLHQREIQVMMGSLVYLRLGLEKSPYCHLLDSS 200 210 220 230 240 250 310 320 330 340 350 360 pF1KB8 HWAEICETFTRDACSLLGLSVESPLSVSFASGCVALPVLMNIKAVIEQRQCTGVWNHKDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 HWAEICETFTRDACSLLGLSVESPLSVSFASGCVALPVLMNIKAVIEQRQCTGVWNHKDE 260 270 280 290 300 310 370 380 390 400 410 420 pF1KB8 LPIEIELGMKCWYHSVFACPILRQQTSDSNPPIKLICGHVISRDALNKLINGGKLKCPYC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 LPIEIELGMKCWYHSVFACPILRQQTSDSNPPIKLICGHVISRDALNKLINGGKLKCPYC 320 330 340 350 360 370 430 pF1KB8 PMEQNPADGKRIIF :::::::::::::: CCDS44 PMEQNPADGKRIIF 380 390 >>CCDS1991.1 RMND5A gene_id:64795|Hs108|chr2 (391 aa) initn: 1859 init1: 1418 opt: 1480 Z-score: 1696.8 bits: 322.9 E(32554): 3.4e-88 Smith-Waterman score: 1816; 63.4% identity (81.8% similar) in 434 aa overlap (1-434:1-391) 10 20 30 40 50 60 pF1KB8 MEQCACVERELDKVLQKFLTYGQHCERSLEELLHYVGQLRAELASAALQGTPLSATLSLV :.::. :::::.:::.:: ::: :::.::::. :.: :. :. .. : . ::.::::: CCDS19 MDQCVTVERELEKVLHKFSGYGQLCERGLEELIDYTGGLKHEILQSHGQDAELSGTLSLV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 MSQCCRKIKDTVQKLASDHKDIHSSVSRVGKAIDRVSTWPAPGVGWEHPEAGMYKDSKES ..:::..:::::::::::::::::::::::::::. CCDS19 LTQCCKRIKDTVQKLASDHKDIHSSVSRVGKAIDK------------------------- 70 80 90 130 140 150 160 170 180 pF1KB8 QQECPHHQALSLLLRQNFDSEICGVVSDAVWDAREQQQQILQMAIVEHLYQQGMLSVAEE ::::.: .: :. :.: ..:..:. ..:::...::::.:::: CCDS19 ----------------NFDSDISSVGIDGCWQA--DSQRLLNEVMVEHFFRQGMLDVAEE 100 110 120 130 190 200 210 220 230 240 pF1KB8 LCQESTLNVDLDFKQPFLELNRILEALHEQDLGPALEWAVSHRQRLLELNSSLEFKLHRL ::::: :.:: . :.::.:::::::::. . : ::::::::.:. :. ::::::::::: CCDS19 LCQESGLSVDPSQKEPFVELNRILEALKVRVLRPALEWAVSNREMLIAQNSSLEFKLHRL 140 150 160 170 180 190 250 260 270 280 290 300 pF1KB8 HFIRLLAGGPAKQLEALSYARHFQPFARLHQREIQVMMGSLVYLRLGLEKSPYCHLLDSS .:: :: :: ..: :::.::..::::: ::..:::.:::::::: :.:.::: ::::.. CCDS19 YFISLLMGGTTNQREALQYAKNFQPFALNHQKDIQVLMGSLVYLRQGIENSPYVHLLDAN 200 210 220 230 240 250 310 320 330 340 350 360 pF1KB8 HWAEICETFTRDACSLLGLSVESPLSVSFASGCVALPVLMNIKAVIEQRQCTGVWNHKDE .::.::. ::::::.::::::::::::::..::::::.:.::::::::::::::::.::: CCDS19 QWADICDIFTRDACALLGLSVESPLSVSFSAGCVALPALINIKAVIEQRQCTGVWNQKDE 260 270 280 290 300 310 370 380 390 400 410 420 pF1KB8 LPIEIELGMKCWYHSVFACPILRQQTSDSNPPIKLICGHVISRDALNKLINGGKLKCPYC ::::..:: ::::::.::::::::::.:.:::.::.:::.::::::::..::.::::::: CCDS19 LPIEVDLGKKCWYHSIFACPILRQQTTDNNPPMKLVCGHIISRDALNKMFNGSKLKCPYC 320 330 340 350 360 370 430 pF1KB8 PMEQNPADGKRIIF ::::.:.:.:.:.: CCDS19 PMEQSPGDAKQIFF 380 390 >>CCDS77888.1 MAEA gene_id:10296|Hs108|chr4 (348 aa) initn: 264 init1: 97 opt: 283 Z-score: 327.6 bits: 69.4 E(32554): 6.3e-12 Smith-Waterman score: 283; 25.8% identity (58.5% similar) in 275 aa overlap (147-418:63-331) 120 130 140 150 160 170 pF1KB8 SKESQQECPHHQALSLLLRQNFDSEICGVVSDAVWDAREQQQQILQMAIVEHLYQQGMLS :: : ... .. .:::: . :. . CCDS77 LKRKAVESIQAEDESAKLCKRRIEHLKEHSSDQPAAASVWKRKRMDRMMVEHLLRCGYYN 40 50 60 70 80 90 180 190 200 210 220 230 pF1KB8 VAEELCQESTLNVDLDFKQPFLELNRILEALHEQDLGPALEWAVSHRQRLLELNSSLEFK .: .: ..: .. :: . :: ... :.:.... . : : ....:: ...: :::. CCDS77 TAVKLARQSGIE-DLVNIEMFLTAKEVEESLERRETATCLAWCHDNKSRLRKMKSCLEFS 100 110 120 130 140 150 240 250 260 270 280 290 pF1KB8 LHRLHFIRLLAGGPAKQLEALSYAR-HFQPFARLHQREIQVMMGSLVYLRLGLEKSPYCH :. .::.:. . :.:.:. .:: ::. . :.. :: :.. . ::: CCDS77 LRIQEFIELIRQN--KRLDAVRHARKHFSQAEGSQLDEVRQAMGMLAF-PPDTHISPYKD 160 170 180 190 200 300 310 320 330 340 350 pF1KB8 LLDSSHWAEICETFTRDACSLLGLSVESPLSVSFASGCVAL--PVLMNIKAVIEQRQCTG ::: ..: . . : : : :. .: ..... .: :. : .. . .. .: CCDS77 LLDPARWRMLIQQFRYDNYRLHQLGNNSVFTLTLQAGLSAIKTPQCYKEDGSSKSPDCPV 210 220 230 240 250 260 360 370 380 390 400 410 pF1KB8 VWNHKDELPIEIELGMKCWYHSVFACPILRQQTSDSNPPIKLICGHVISRDALNKLINGG ..: . .. .: .: ..: : . ...:::. : :.: . ..: .. . CCDS77 CSRSLNKLAQPLPMA-HC-ANSRLVCKISGDVMNENNPPMMLPNGYVYGYNSLLSIRQDD 270 280 290 300 310 320 420 430 pF1KB8 KLKCPYCPMEQNPADGKRIIF :. :: CCDS77 KVVCPRTKEVFHFSQAEKVYIM 330 340 >>CCDS75090.1 MAEA gene_id:10296|Hs108|chr4 (395 aa) initn: 264 init1: 97 opt: 283 Z-score: 326.7 bits: 69.4 E(32554): 7e-12 Smith-Waterman score: 283; 25.8% identity (58.5% similar) in 275 aa overlap (147-418:110-378) 120 130 140 150 160 170 pF1KB8 SKESQQECPHHQALSLLLRQNFDSEICGVVSDAVWDAREQQQQILQMAIVEHLYQQGMLS :: : ... .. .:::: . :. . CCDS75 LKRKAVESIQAEDESAKLCKRRIEHLKEHSSDQPAAASVWKRKRMDRMMVEHLLRCGYYN 80 90 100 110 120 130 180 190 200 210 220 230 pF1KB8 VAEELCQESTLNVDLDFKQPFLELNRILEALHEQDLGPALEWAVSHRQRLLELNSSLEFK .: .: ..: .. :: . :: ... :.:.... . : : ....:: ...: :::. CCDS75 TAVKLARQSGIE-DLVNIEMFLTAKEVEESLERRETATCLAWCHDNKSRLRKMKSCLEFS 140 150 160 170 180 190 240 250 260 270 280 290 pF1KB8 LHRLHFIRLLAGGPAKQLEALSYAR-HFQPFARLHQREIQVMMGSLVYLRLGLEKSPYCH :. .::.:. . :.:.:. .:: ::. . :.. :: :.. . ::: CCDS75 LRIQEFIELIRQN--KRLDAVRHARKHFSQAEGSQLDEVRQAMGMLAF-PPDTHISPYKD 200 210 220 230 240 250 300 310 320 330 340 350 pF1KB8 LLDSSHWAEICETFTRDACSLLGLSVESPLSVSFASGCVAL--PVLMNIKAVIEQRQCTG ::: ..: . . : : : :. .: ..... .: :. : .. . .. .: CCDS75 LLDPARWRMLIQQFRYDNYRLHQLGNNSVFTLTLQAGLSAIKTPQCYKEDGSSKSPDCPV 260 270 280 290 300 310 360 370 380 390 400 410 pF1KB8 VWNHKDELPIEIELGMKCWYHSVFACPILRQQTSDSNPPIKLICGHVISRDALNKLINGG ..: . .. .: .: ..: : . ...:::. : :.: . ..: .. . CCDS75 CSRSLNKLAQPLPMA-HC-ANSRLVCKISGDVMNENNPPMMLPNGYVYGYNSLLSIRQDD 320 330 340 350 360 370 420 430 pF1KB8 KLKCPYCPMEQNPADGKRIIF :. :: CCDS75 KVVCPRTKEVFHFSQAEKVYIM 380 390 >>CCDS33936.1 MAEA gene_id:10296|Hs108|chr4 (396 aa) initn: 264 init1: 97 opt: 283 Z-score: 326.7 bits: 69.4 E(32554): 7.1e-12 Smith-Waterman score: 283; 25.8% identity (58.5% similar) in 275 aa overlap (147-418:111-379) 120 130 140 150 160 170 pF1KB8 SKESQQECPHHQALSLLLRQNFDSEICGVVSDAVWDAREQQQQILQMAIVEHLYQQGMLS :: : ... .. .:::: . :. . CCDS33 LKRKAVESIQAEDESAKLCKRRIEHLKEHSSDQPAAASVWKRKRMDRMMVEHLLRCGYYN 90 100 110 120 130 140 180 190 200 210 220 230 pF1KB8 VAEELCQESTLNVDLDFKQPFLELNRILEALHEQDLGPALEWAVSHRQRLLELNSSLEFK .: .: ..: .. :: . :: ... :.:.... . : : ....:: ...: :::. CCDS33 TAVKLARQSGIE-DLVNIEMFLTAKEVEESLERRETATCLAWCHDNKSRLRKMKSCLEFS 150 160 170 180 190 240 250 260 270 280 290 pF1KB8 LHRLHFIRLLAGGPAKQLEALSYAR-HFQPFARLHQREIQVMMGSLVYLRLGLEKSPYCH :. .::.:. . :.:.:. .:: ::. . :.. :: :.. . ::: CCDS33 LRIQEFIELIRQN--KRLDAVRHARKHFSQAEGSQLDEVRQAMGMLAF-PPDTHISPYKD 200 210 220 230 240 250 300 310 320 330 340 350 pF1KB8 LLDSSHWAEICETFTRDACSLLGLSVESPLSVSFASGCVAL--PVLMNIKAVIEQRQCTG ::: ..: . . : : : :. .: ..... .: :. : .. . .. .: CCDS33 LLDPARWRMLIQQFRYDNYRLHQLGNNSVFTLTLQAGLSAIKTPQCYKEDGSSKSPDCPV 260 270 280 290 300 310 360 370 380 390 400 410 pF1KB8 VWNHKDELPIEIELGMKCWYHSVFACPILRQQTSDSNPPIKLICGHVISRDALNKLINGG ..: . .. .: .: ..: : . ...:::. : :.: . ..: .. . CCDS33 CSRSLNKLAQPLPMA-HC-ANSRLVCKISGDVMNENNPPMMLPNGYVYGYNSLLSIRQDD 320 330 340 350 360 370 420 430 pF1KB8 KLKCPYCPMEQNPADGKRIIF :. :: CCDS33 KVVCPRTKEVFHFSQAEKVYIM 380 390 434 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 10:17:14 2016 done: Fri Nov 4 10:17:15 2016 Total Scan time: 2.910 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]