FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8190, 149 aa 1>>>pF1KB8190 149 - 149 aa - 149 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.3109+/-0.000367; mu= 11.0668+/- 0.023 mean_var=58.2310+/-11.649, 0's: 0 Z-trim(112.4): 13 B-trim: 169 in 1/51 Lambda= 0.168073 statistics sampled from 21314 (21324) to 21314 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.636), E-opt: 0.2 (0.25), width: 16 Scan time: 4.860 The best scores are: opt bits E(85289) NP_006692 (OMIM: 608572,611595) thioredoxin-like p ( 142) 379 100.0 1.4e-21 NP_001292486 (OMIM: 608572,611595) thioredoxin-lik ( 134) 351 93.2 1.5e-19 NP_001290400 (OMIM: 608572,611595) thioredoxin-lik ( 103) 216 60.5 8.2e-10 NP_001292492 (OMIM: 608572,611595) thioredoxin-lik ( 71) 175 50.5 5.8e-07 NP_001292493 (OMIM: 608572,611595) thioredoxin-lik ( 71) 175 50.5 5.8e-07 NP_006532 (OMIM: 612754) glutaredoxin-3 isoform 1 ( 335) 132 40.3 0.0032 NP_001186797 (OMIM: 612754) glutaredoxin-3 isoform ( 335) 132 40.3 0.0032 >>NP_006692 (OMIM: 608572,611595) thioredoxin-like prote (142 aa) initn: 436 init1: 369 opt: 379 Z-score: 508.5 bits: 100.0 E(85289): 1.4e-21 Smith-Waterman score: 379; 37.8% identity (77.6% similar) in 143 aa overlap (1-142:1-142) 10 20 30 40 50 60 pF1KB8 MSFLLPKLTSKKEVDQAIKSTAEKVLVLRFGRDEDPVCLQLDDILSKTSSDLSKMAAIYL ::..::.: . .::::: : ..:.:.:::.: ::.:...:..: . . ....:.::: NP_006 MSYMLPHLHNGWQVDQAILSEEDRVVVIRFGHDWDPTCMKMDEVLYSIAEKVKNFAVIYL 10 20 30 40 50 60 70 80 90 100 110 pF1KB8 VDVDQTAVYTQYFDISYIPSTV-FFFNGQHMKVDYGSPDHTKFVGSFKTKQDFIDLIEVI ::. .. ....... : : :: ::: ..:. .: :. ...:. ... ::...:.::.. NP_006 VDITEVPDFNKMYEL-YDPCTVMFFFRNKHIMIDLGTGNNNKINWAMEDKQEMVDIIETV 70 80 90 100 110 120 130 140 pF1KB8 YRGAMRGKLIVQSPIDPKNIPKYDLLYQDI :::: .:. .: :: : .. .: NP_006 YRGARKGRGLVVSPKDYSTKYRY 120 130 140 >>NP_001292486 (OMIM: 608572,611595) thioredoxin-like pr (134 aa) initn: 391 init1: 198 opt: 351 Z-score: 472.2 bits: 93.2 E(85289): 1.5e-19 Smith-Waterman score: 351; 37.1% identity (74.8% similar) in 143 aa overlap (1-142:1-134) 10 20 30 40 50 60 pF1KB8 MSFLLPKLTSKKEVDQAIKSTAEKVLVLRFGRDEDPVCLQLDDILSKTSSDLSKMAAIYL ::..::.: . .::::: : ..:.:.:::.: ::.:...:.. ...:.::: NP_001 MSYMLPHLHNGWQVDQAILSEEDRVVVIRFGHDWDPTCMKMDEV--------KNFAVIYL 10 20 30 40 50 70 80 90 100 110 pF1KB8 VDVDQTAVYTQYFDISYIPSTV-FFFNGQHMKVDYGSPDHTKFVGSFKTKQDFIDLIEVI ::. .. ....... : : :: ::: ..:. .: :. ...:. ... ::...:.::.. NP_001 VDITEVPDFNKMYEL-YDPCTVMFFFRNKHIMIDLGTGNNNKINWAMEDKQEMVDIIETV 60 70 80 90 100 110 120 130 140 pF1KB8 YRGAMRGKLIVQSPIDPKNIPKYDLLYQDI :::: .:. .: :: : .. .: NP_001 YRGARKGRGLVVSPKDYSTKYRY 120 130 >>NP_001290400 (OMIM: 608572,611595) thioredoxin-like pr (103 aa) initn: 241 init1: 198 opt: 216 Z-score: 297.1 bits: 60.5 E(85289): 8.2e-10 Smith-Waterman score: 216; 34.4% identity (77.4% similar) in 93 aa overlap (51-142:12-103) 30 40 50 60 70 80 pF1KB8 TAEKVLVLRFGRDEDPVCLQLDDILSKTSSDLSKMAAIYLVDVDQTAVYTQYFDISYIPS .....:.:::::. .. ....... : : NP_001 MLLARKQILCVNVKNFAVIYLVDITEVPDFNKMYEL-YDPC 10 20 30 40 90 100 110 120 130 pF1KB8 TV-FFFNGQHMKVDYGSPDHTKFVGSFKTKQDFIDLIEVIYRGAMRGKLIVQSPIDPKNI :: ::: ..:. .: :. ...:. ... ::...:.::..:::: .:. .: :: : .. NP_001 TVMFFFRNKHIMIDLGTGNNNKINWAMEDKQEMVDIIETVYRGARKGRGLVVSPKDYSTK 50 60 70 80 90 100 140 pF1KB8 PKYDLLYQDI .: NP_001 YRY >>NP_001292492 (OMIM: 608572,611595) thioredoxin-like pr (71 aa) initn: 205 init1: 162 opt: 175 Z-score: 246.0 bits: 50.5 E(85289): 5.8e-07 Smith-Waterman score: 175; 38.8% identity (74.6% similar) in 67 aa overlap (77-142:5-71) 50 60 70 80 90 100 pF1KB8 KTSSDLSKMAAIYLVDVDQTAVYTQYFDISYIPSTV-FFFNGQHMKVDYGSPDHTKFVGS : : :: ::: ..:. .: :. ...:. . NP_001 MYELYDPCTVMFFFRNKHIMIDLGTGNNNKINWA 10 20 30 110 120 130 140 pF1KB8 FKTKQDFIDLIEVIYRGAMRGKLIVQSPIDPKNIPKYDLLYQDI .. ::...:.::..:::: .:. .: :: : .. .: NP_001 MEDKQEMVDIIETVYRGARKGRGLVVSPKDYSTKYRY 40 50 60 70 >>NP_001292493 (OMIM: 608572,611595) thioredoxin-like pr (71 aa) initn: 205 init1: 162 opt: 175 Z-score: 246.0 bits: 50.5 E(85289): 5.8e-07 Smith-Waterman score: 175; 38.8% identity (74.6% similar) in 67 aa overlap (77-142:5-71) 50 60 70 80 90 100 pF1KB8 KTSSDLSKMAAIYLVDVDQTAVYTQYFDISYIPSTV-FFFNGQHMKVDYGSPDHTKFVGS : : :: ::: ..:. .: :. ...:. . NP_001 MYELYDPCTVMFFFRNKHIMIDLGTGNNNKINWA 10 20 30 110 120 130 140 pF1KB8 FKTKQDFIDLIEVIYRGAMRGKLIVQSPIDPKNIPKYDLLYQDI .. ::...:.::..:::: .:. .: :: : .. .: NP_001 MEDKQEMVDIIETVYRGARKGRGLVVSPKDYSTKYRY 40 50 60 70 >>NP_006532 (OMIM: 612754) glutaredoxin-3 isoform 1 [Hom (335 aa) initn: 51 init1: 51 opt: 132 Z-score: 178.8 bits: 40.3 E(85289): 0.0032 Smith-Waterman score: 132; 21.7% identity (66.0% similar) in 106 aa overlap (10-113:18-122) 10 20 30 40 50 pF1KB8 MSFLLPKLTSKKEVDQAIKSTAEKVLVLRFGRDEDPVCLQLDDILSKTSSDL : . .. .. :...::..: : : :....... ...: NP_006 MAAGAAEAAVAAVEEVGSAGQFEELLRLKAKSLLVVHFWAPWAPQCAQMNEVMAELAKEL 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB8 SKMAAIYLVDVDQTAVYTQYFDISYIPSTVFFFNGQHM-KVDYG-SPDHTKFVGSFKTKQ ... . : ... . .. ..:: .:. .:: :.:.. ..: . .:. :: : .. NP_006 PQVSFVKL-EAEGVPEVSEKYEISSVPTFLFFKNSQKIDRLDGAHAPELTKKVQRHASSG 70 80 90 100 110 120 130 140 pF1KB8 DFIDLIEVIYRGAMRGKLIVQSPIDPKNIPKYDLLYQDI .:. NP_006 SFLPSANEHLKEDLNLRLKKLTHAAPCMLFMKGTPQEPRCGFSKQMVEILHKHNIQFSSF 120 130 140 150 160 170 >>NP_001186797 (OMIM: 612754) glutaredoxin-3 isoform 1 [ (335 aa) initn: 51 init1: 51 opt: 132 Z-score: 178.8 bits: 40.3 E(85289): 0.0032 Smith-Waterman score: 132; 21.7% identity (66.0% similar) in 106 aa overlap (10-113:18-122) 10 20 30 40 50 pF1KB8 MSFLLPKLTSKKEVDQAIKSTAEKVLVLRFGRDEDPVCLQLDDILSKTSSDL : . .. .. :...::..: : : :....... ...: NP_001 MAAGAAEAAVAAVEEVGSAGQFEELLRLKAKSLLVVHFWAPWAPQCAQMNEVMAELAKEL 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB8 SKMAAIYLVDVDQTAVYTQYFDISYIPSTVFFFNGQHM-KVDYG-SPDHTKFVGSFKTKQ ... . : ... . .. ..:: .:. .:: :.:.. ..: . .:. :: : .. NP_001 PQVSFVKL-EAEGVPEVSEKYEISSVPTFLFFKNSQKIDRLDGAHAPELTKKVQRHASSG 70 80 90 100 110 120 130 140 pF1KB8 DFIDLIEVIYRGAMRGKLIVQSPIDPKNIPKYDLLYQDI .:. NP_001 SFLPSANEHLKEDLNLRLKKLTHAAPCMLFMKGTPQEPRCGFSKQMVEILHKHNIQFSSF 120 130 140 150 160 170 149 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 10:22:12 2016 done: Fri Nov 4 10:22:12 2016 Total Scan time: 4.860 Total Display time: -0.040 Function used was FASTA [36.3.4 Apr, 2011]