Result of FASTA (ccds) for
pF1KB8191
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB8191, 425 aa
1>>>pF1KB8191 425 - 425 aa - 425 aa
Library: human.CCDS.faa
18511270 residues in 32554 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.4848+/-0.000887; mu= 7.2706+/- 0.053
mean_var=128.2560+/-25.647, 0's: 0 Z-trim(111.0): 15 B-trim: 291 in 1/51
Lambda= 0.113249
statistics sampled from 12010 (12024) to 12010 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.733), E-opt: 0.2 (0.369), width: 16
Scan time: 2.160
The best scores are: opt bits E(32554)
CCDS10222.1 SMAD3 gene_id:4088|Hs108|chr15 ( 425) 2990 499.7 2.3e-141
CCDS45288.1 SMAD3 gene_id:4088|Hs108|chr15 ( 381) 2544 426.8 1.8e-119
CCDS11934.1 SMAD2 gene_id:4087|Hs108|chr18 ( 467) 2342 393.8 1.8e-109
CCDS53950.1 SMAD3 gene_id:4088|Hs108|chr15 ( 320) 2261 380.5 1.3e-105
CCDS9360.1 SMAD9 gene_id:4093|Hs108|chr13 ( 430) 1893 320.4 2.1e-87
CCDS53951.1 SMAD3 gene_id:4088|Hs108|chr15 ( 230) 1615 274.9 5.7e-74
CCDS75308.1 SMAD5 gene_id:4090|Hs108|chr5 ( 465) 1218 210.2 3.5e-54
CCDS3765.1 SMAD1 gene_id:4086|Hs108|chr4 ( 465) 1192 205.9 6.6e-53
CCDS45032.1 SMAD9 gene_id:4093|Hs108|chr13 ( 467) 1153 199.5 5.5e-51
CCDS11950.1 SMAD4 gene_id:4089|Hs108|chr18 ( 552) 472 88.3 2e-17
CCDS10221.1 SMAD6 gene_id:4091|Hs108|chr15 ( 496) 386 74.2 3.1e-13
>>CCDS10222.1 SMAD3 gene_id:4088|Hs108|chr15 (425 aa)
initn: 2990 init1: 2990 opt: 2990 Z-score: 2651.5 bits: 499.7 E(32554): 2.3e-141
Smith-Waterman score: 2990; 100.0% identity (100.0% similar) in 425 aa overlap (1-425:1-425)
10 20 30 40 50 60
pF1KB8 MSSILPFTPPIVKRLLGWKKGEQNGQEEKWCEKAVKSLVKKLKKTGQLDELEKAITTQNV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS10 MSSILPFTPPIVKRLLGWKKGEQNGQEEKWCEKAVKSLVKKLKKTGQLDELEKAITTQNV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 NTKCITIPRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELRAMELCEFAFNMKKDEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS10 NTKCITIPRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELRAMELCEFAFNMKKDEV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 CVNPYHYQRVETPVLPPVLVPRHTEIPAEFPPLDDYSHSIPENTNFPAGIEPQSNIPETP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS10 CVNPYHYQRVETPVLPPVLVPRHTEIPAEFPPLDDYSHSIPENTNFPAGIEPQSNIPETP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB8 PPGYLSEDGETSDHQMNHSMDAGSPNLSPNPMSPAHNNLDLQPVTYCEPAFWCSISYYEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS10 PPGYLSEDGETSDHQMNHSMDAGSPNLSPNPMSPAHNNLDLQPVTYCEPAFWCSISYYEL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB8 NQRVGETFHASQPSMTVDGFTDPSNSERFCLGLLSNVNRNAAVELTRRHIGRGVRLYYIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS10 NQRVGETFHASQPSMTVDGFTDPSNSERFCLGLLSNVNRNAAVELTRRHIGRGVRLYYIG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB8 GEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS10 GEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGF
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB8 EAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS10 EAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSIR
370 380 390 400 410 420
pF1KB8 CSSVS
:::::
CCDS10 CSSVS
>>CCDS45288.1 SMAD3 gene_id:4088|Hs108|chr15 (381 aa)
initn: 2540 init1: 2540 opt: 2544 Z-score: 2258.4 bits: 426.8 E(32554): 1.8e-119
Smith-Waterman score: 2544; 98.1% identity (98.6% similar) in 366 aa overlap (60-425:16-381)
30 40 50 60 70 80
pF1KB8 WCEKAVKSLVKKLKKTGQLDELEKAITTQNVNTKCITIPRSLDGRLQVSHRKGLPHVIYC
:. : . :::::::::::::::::::::
CCDS45 MSCLHPRQTWKGAALVHRKAWWMGRSLDGRLQVSHRKGLPHVIYC
10 20 30 40
90 100 110 120 130 140
pF1KB8 RLWRWPDLHSHHELRAMELCEFAFNMKKDEVCVNPYHYQRVETPVLPPVLVPRHTEIPAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS45 RLWRWPDLHSHHELRAMELCEFAFNMKKDEVCVNPYHYQRVETPVLPPVLVPRHTEIPAE
50 60 70 80 90 100
150 160 170 180 190 200
pF1KB8 FPPLDDYSHSIPENTNFPAGIEPQSNIPETPPPGYLSEDGETSDHQMNHSMDAGSPNLSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS45 FPPLDDYSHSIPENTNFPAGIEPQSNIPETPPPGYLSEDGETSDHQMNHSMDAGSPNLSP
110 120 130 140 150 160
210 220 230 240 250 260
pF1KB8 NPMSPAHNNLDLQPVTYCEPAFWCSISYYELNQRVGETFHASQPSMTVDGFTDPSNSERF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS45 NPMSPAHNNLDLQPVTYCEPAFWCSISYYELNQRVGETFHASQPSMTVDGFTDPSNSERF
170 180 190 200 210 220
270 280 290 300 310 320
pF1KB8 CLGLLSNVNRNAAVELTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS45 CLGLLSNVNRNAAVELTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPA
230 240 250 260 270 280
330 340 350 360 370 380
pF1KB8 TVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS45 TVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTV
290 300 310 320 330 340
390 400 410 420
pF1KB8 TSTPCWIELHLNGPLQWLDKVLTQMGSPSIRCSSVS
::::::::::::::::::::::::::::::::::::
CCDS45 TSTPCWIELHLNGPLQWLDKVLTQMGSPSIRCSSVS
350 360 370 380
>>CCDS11934.1 SMAD2 gene_id:4087|Hs108|chr18 (467 aa)
initn: 2301 init1: 1454 opt: 2342 Z-score: 2078.7 bits: 393.8 E(32554): 1.8e-109
Smith-Waterman score: 2608; 83.6% identity (89.7% similar) in 457 aa overlap (11-425:11-467)
10 20 30 40 50
pF1KB8 MSSILPFTPPIVKRLLGWKK----------GEQNGQEEKWCEKAVKSLVKKLKKTGQLDE
.::::::::: ::::::::::::::::::::::::::.:::
CCDS11 MSSILPFTPPVVKRLLGWKKSAGGSGGAGGGEQNGQEEKWCEKAVKSLVKKLKKTGRLDE
10 20 30 40 50 60
60 70 80
pF1KB8 LEKAITTQNVNTKCITIP------------------------------RSLDGRLQVSHR
::::::::: ::::.::: ::::::::::::
CCDS11 LEKAITTQNCNTKCVTIPSTCSEIWGLSTPNTIDQWDTTGLYSFSEQTRSLDGRLQVSHR
70 80 90 100 110 120
90 100 110 120 130 140
pF1KB8 KGLPHVIYCRLWRWPDLHSHHELRAMELCEFAFNMKKDEVCVNPYHYQRVETPVLPPVLV
:::::::::::::::::::::::.:.: ::.:::.:::::::::::::::::::::::::
CCDS11 KGLPHVIYCRLWRWPDLHSHHELKAIENCEYAFNLKKDEVCVNPYHYQRVETPVLPPVLV
130 140 150 160 170 180
150 160 170 180 190
pF1KB8 PRHTEIPAEFPPLDDYSHSIPENTNFPAGIEPQSN-IPETPPPGYLSEDGETSDHQMNHS
:::::: .:.::::::.:::::::::::::::::: :::::::::.::::::::.:.:.:
CCDS11 PRHTEILTELPPLDDYTHSIPENTNFPAGIEPQSNYIPETPPPGYISEDGETSDQQLNQS
190 200 210 220 230 240
200 210 220 230 240 250
pF1KB8 MDAGSP-NLSPNPMSPAHNNLDLQPVTYCEPAFWCSISYYELNQRVGETFHASQPSMTVD
::.::: .:::. .::....:::::::: ::::::::.::::::::::::::::::.:::
CCDS11 MDTGSPAELSPTTLSPVNHSLDLQPVTYSEPAFWCSIAYYELNQRVGETFHASQPSLTVD
250 260 270 280 290 300
260 270 280 290 300 310
pF1KB8 GFTDPSNSERFCLGLLSNVNRNAAVELTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSP
:::::::::::::::::::::::.::.:::::::::::::::::::::::::::::::::
CCDS11 GFTDPSNSERFCLGLLSNVNRNATVEMTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSP
310 320 330 340 350 360
320 330 340 350 360 370
pF1KB8 NCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS11 NCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVK
370 380 390 400 410 420
380 390 400 410 420
pF1KB8 GWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSIRCSSVS
::::::::::::::::::::::::::::::::::::::::.::::.:
CCDS11 GWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSVRCSSMS
430 440 450 460
>>CCDS53950.1 SMAD3 gene_id:4088|Hs108|chr15 (320 aa)
initn: 2261 init1: 2261 opt: 2261 Z-score: 2009.7 bits: 380.5 E(32554): 1.3e-105
Smith-Waterman score: 2261; 100.0% identity (100.0% similar) in 320 aa overlap (106-425:1-320)
80 90 100 110 120 130
pF1KB8 QVSHRKGLPHVIYCRLWRWPDLHSHHELRAMELCEFAFNMKKDEVCVNPYHYQRVETPVL
::::::::::::::::::::::::::::::
CCDS53 MELCEFAFNMKKDEVCVNPYHYQRVETPVL
10 20 30
140 150 160 170 180 190
pF1KB8 PPVLVPRHTEIPAEFPPLDDYSHSIPENTNFPAGIEPQSNIPETPPPGYLSEDGETSDHQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS53 PPVLVPRHTEIPAEFPPLDDYSHSIPENTNFPAGIEPQSNIPETPPPGYLSEDGETSDHQ
40 50 60 70 80 90
200 210 220 230 240 250
pF1KB8 MNHSMDAGSPNLSPNPMSPAHNNLDLQPVTYCEPAFWCSISYYELNQRVGETFHASQPSM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS53 MNHSMDAGSPNLSPNPMSPAHNNLDLQPVTYCEPAFWCSISYYELNQRVGETFHASQPSM
100 110 120 130 140 150
260 270 280 290 300 310
pF1KB8 TVDGFTDPSNSERFCLGLLSNVNRNAAVELTRRHIGRGVRLYYIGGEVFAECLSDSAIFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS53 TVDGFTDPSNSERFCLGLLSNVNRNAAVELTRRHIGRGVRLYYIGGEVFAECLSDSAIFV
160 170 180 190 200 210
320 330 340 350 360 370
pF1KB8 QSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS53 QSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMS
220 230 240 250 260 270
380 390 400 410 420
pF1KB8 FVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSIRCSSVS
::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS53 FVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSIRCSSVS
280 290 300 310 320
>>CCDS9360.1 SMAD9 gene_id:4093|Hs108|chr13 (430 aa)
initn: 990 init1: 898 opt: 1893 Z-score: 1682.8 bits: 320.4 E(32554): 2.1e-87
Smith-Waterman score: 1893; 64.2% identity (82.6% similar) in 436 aa overlap (1-425:7-430)
10 20 30 40 50
pF1KB8 MSSILPFTPPIVKRLLGWKKGEQNGQEEKWCEKAVKSLVKKLKKT-GQLDELEK
.::.. :: : ::::::::.:.. :::: :::: :::::::: : .::::.
CCDS93 MHSTTPISSLFSFTSPAVKRLLGWKQGDE---EEKWAEKAVDSLVKKLKKKKGAMDELER
10 20 30 40 50
60 70 80 90 100 110
pF1KB8 AITTQNVNTKCITIPRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELRAMELCEFAF
:.. . .::.:::::::::::::::::::::::::.::::::.:::::. .: ::: :
CCDS93 ALSCPGQPSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPF
60 70 80 90 100 110
120 130 140 150 160
pF1KB8 NMKKDEVCVNPYHYQRVETPVLPPVLVPRHTEIPAEFPPLDDYS----HS---IPENTNF
. :. :::.:::::.:::::::::::::::.: .. : . :: .:.:...
CCDS93 GSKQKEVCINPYHYRRVETPVLPPVLVPRHSEYNPQLSLLAKFRSASLHSEPLMPHNATY
120 130 140 150 160 170
170 180 190 200 210 220
pF1KB8 PAGIE--PQSNIPETPPPGYLSEDGETSDHQMNHSMDAGSPNLSPNPMSPAHNNLDLQPV
: ... : : .: .: .. :.. :... :: :::. .: :: ... :..::
CCDS93 PDSFQQPPCSALPPSPSHAF-SQSPCTASYP--HS--PGSPS---EPESPYQHS-DFRPV
180 190 200 210 220
230 240 250 260 270 280
pF1KB8 TYCEPAFWCSISYYELNQRVGETFHASQPSMTVDGFTDPSNSE-RFCLGLLSNVNRNAAV
: :: :::..:::::.::::::.::. :. .::::::::.. :::::::::::::...
CCDS93 CYEEPQHWCSVAYYELNNRVGETFQASSRSVLIDGFTDPSNNRNRFCLGLLSNVNRNSTI
230 240 250 260 270 280
290 300 310 320 330 340
pF1KB8 ELTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIF
: ::::::.::.:::.::::.:::.:::.::::: ::: ..:.::::::::: ::.::.:
CCDS93 ENTRRHIGKGVHLYYVGGEVYAECVSDSSIFVQSRNCNYQHGFHPATVCKIPSGCSLKVF
290 300 310 320 330 340
350 360 370 380 390 400
pF1KB8 NNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGP
::: :: ::::::..:::.::.::.::::::::::::::::.:: :::::::::.::.::
CCDS93 NNQLFAQLLAQSVHHGFEVVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGP
350 360 370 380 390 400
410 420
pF1KB8 LQWLDKVLTQMGSPSIRCSSVS
:::::::::::::: ::::
CCDS93 LQWLDKVLTQMGSPHNPISSVS
410 420 430
>>CCDS53951.1 SMAD3 gene_id:4088|Hs108|chr15 (230 aa)
initn: 1615 init1: 1615 opt: 1615 Z-score: 1441.5 bits: 274.9 E(32554): 5.7e-74
Smith-Waterman score: 1615; 100.0% identity (100.0% similar) in 230 aa overlap (196-425:1-230)
170 180 190 200 210 220
pF1KB8 FPAGIEPQSNIPETPPPGYLSEDGETSDHQMNHSMDAGSPNLSPNPMSPAHNNLDLQPVT
::::::::::::::::::::::::::::::
CCDS53 MNHSMDAGSPNLSPNPMSPAHNNLDLQPVT
10 20 30
230 240 250 260 270 280
pF1KB8 YCEPAFWCSISYYELNQRVGETFHASQPSMTVDGFTDPSNSERFCLGLLSNVNRNAAVEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS53 YCEPAFWCSISYYELNQRVGETFHASQPSMTVDGFTDPSNSERFCLGLLSNVNRNAAVEL
40 50 60 70 80 90
290 300 310 320 330 340
pF1KB8 TRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS53 TRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNN
100 110 120 130 140 150
350 360 370 380 390 400
pF1KB8 QEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS53 QEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQ
160 170 180 190 200 210
410 420
pF1KB8 WLDKVLTQMGSPSIRCSSVS
::::::::::::::::::::
CCDS53 WLDKVLTQMGSPSIRCSSVS
220 230
>>CCDS75308.1 SMAD5 gene_id:4090|Hs108|chr5 (465 aa)
initn: 1508 init1: 904 opt: 1218 Z-score: 1086.2 bits: 210.2 E(32554): 3.5e-54
Smith-Waterman score: 1870; 61.3% identity (78.6% similar) in 462 aa overlap (7-425:10-465)
10 20 30 40 50
pF1KB8 MSSILPFTPPIVKRLLGWKKGEQNGQEEKWCEKAVKSLVKKLKKT-GQLDELEKAIT
:: : ::::::::.:. .:::: :::: .::::::: : ..:::::..
CCDS75 MTSMASLFSFTSPAVKRLLGWKQGD---EEEKWAEKAVDALVKKLKKKKGAMEELEKALS
10 20 30 40 50
60 70 80 90 100 110
pF1KB8 TQNVNTKCITIPRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELRAMELCEFAFNMK
. . .::.:::::::::::::::::::::::::.::::::.:::::. ...::: :. :
CCDS75 SPGQPSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLDICEFPFGSK
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB8 KDEVCVNPYHYQRVETPVLPPVLVPRHTEIPAEFPPLDDY---SHS---IPENTNFPAGI
. :::.:::::.:::.:::::::::::.:. . : .. ::. .:.:..:: ..
CCDS75 QKEVCINPYHYKRVESPVLPPVLVPRHNEFNPQHSLLVQFRNLSHNEPHMPQNATFPDSF
120 130 140 150 160 170
180 190
pF1KB8 EPQSNIP-----------------------------------ETPPPGYLSEDGETSDHQ
. .: : .::::.:. : . . ..
CCDS75 HQPNNTPFPLSPNSPYPPSPASSTYPNSPASSGPGSPFQLPADTPPPAYMPPDDQMG-QD
180 190 200 210 220 230
200 210 220 230 240 250
pF1KB8 MNHSMDAGSPNLSPNPMSPAHNNLDLQPVTYCEPAFWCSISYYELNQRVGETFHASQPSM
.. ::. : :. :. : :. .. :.:::.: :: :::: :::::.::::.::::. :.
CCDS75 NSQPMDT-SNNMIPQIM-PSISSRDVQPVAYEEPKHWCSIVYYELNNRVGEAFHASSTSV
240 250 260 270 280 290
260 270 280 290 300 310
pF1KB8 TVDGFTDPSNSE-RFCLGLLSNVNRNAAVELTRRHIGRGVRLYYIGGEVFAECLSDSAIF
:::::::::.. :::::::::::::...: ::::::.::.:::.::::.:::::::.::
CCDS75 LVDGFTDPSNNKSRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIF
300 310 320 330 340 350
320 330 340 350 360 370
pF1KB8 VQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRM
::: ::: ..:.::.:::::: .:.:::::::::: :::::::.::::::.::.::::::
CCDS75 VQSRNCNFHHGFHPTTVCKIPSSCSLKIFNNQEFAQLLAQSVNHGFEAVYELTKMCTIRM
360 370 380 390 400 410
380 390 400 410 420
pF1KB8 SFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSIRCSSVS
::::::::::.:: :::::::::.::.:::::::::::::::: ::::
CCDS75 SFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPLNPISSVS
420 430 440 450 460
>>CCDS3765.1 SMAD1 gene_id:4086|Hs108|chr4 (465 aa)
initn: 1611 init1: 913 opt: 1192 Z-score: 1063.3 bits: 205.9 E(32554): 6.6e-53
Smith-Waterman score: 1856; 62.0% identity (77.6% similar) in 460 aa overlap (7-425:9-465)
10 20 30 40 50
pF1KB8 MSSILPFTPPIVKRLLGWKKGEQNGQEEKWCEKAVKSLVKKLKKT-GQLDELEKAITT
:: : ::::::::.:. .:::: :::: .::::::: : ..:::::..
CCDS37 MNVTSLFSFTSPAVKRLLGWKQGD---EEEKWAEKAVDALVKKLKKKKGAMEELEKALSC
10 20 30 40 50
60 70 80 90 100 110
pF1KB8 QNVNTKCITIPRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELRAMELCEFAFNMKK
. ..:.:::::::::::::::::::::::::.::::::.:::::. .: ::: :. :.
CCDS37 PGQPSNCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSKQ
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB8 DEVCVNPYHYQRVETPVLPPVLVPRHTEI-P-----AEFPPLDDYSHSIPENTNFPAGIE
:::.:::::.:::.:::::::::::.: : :.: : . .: :..:: ...
CCDS37 KEVCINPYHYKRVESPVLPPVLVPRHSEYNPQHSLLAQFRNLGQNEPHMPLNATFPDSFQ
120 130 140 150 160 170
180 190 200 210
pF1KB8 -PQSN-IPETPPPGYLSEDGETSDHQMNH--SMDAGSPNLSP------------NPMS--
:.:. .:..: .: . : .:. . : : ::: : .::.
CCDS37 QPNSHPFPHSPNSSYPNSPGSSSSTYPHSPTSSDPGSPFQMPADTPPPAYLPPEDPMTQD
180 190 200 210 220 230
220 230 240 250
pF1KB8 ---PAHNNL------------DLQPVTYCEPAFWCSISYYELNQRVGETFHASQPSMTVD
: .:. :.: :.: :: :::: :::::.::::.::::. :. ::
CCDS37 GSQPMDTNMMAPPLPSEINRGDVQAVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVD
240 250 260 270 280 290
260 270 280 290 300 310
pF1KB8 GFTDPSNSE-RFCLGLLSNVNRNAAVELTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQS
:::::::.. :::::::::::::...: ::::::.::.:::.::::.:::::::.:::::
CCDS37 GFTDPSNNKNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQS
300 310 320 330 340 350
320 330 340 350 360 370
pF1KB8 PNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFV
::: ..:.::.:::::: ::.:::::::::: :::::::.:::.::.::.:::::::::
CCDS37 RNCNYHHGFHPTTVCKIPSGCSLKIFNNQEFAQLLAQSVNHGFETVYELTKMCTIRMSFV
360 370 380 390 400 410
380 390 400 410 420
pF1KB8 KGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSIRCSSVS
:::::::.:: :::::::::.::.:::::::::::::::: ::::
CCDS37 KGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS
420 430 440 450 460
>>CCDS45032.1 SMAD9 gene_id:4093|Hs108|chr13 (467 aa)
initn: 1559 init1: 898 opt: 1153 Z-score: 1028.8 bits: 199.5 E(32554): 5.5e-51
Smith-Waterman score: 1838; 61.0% identity (77.8% similar) in 459 aa overlap (7-425:13-467)
10 20 30 40 50
pF1KB8 MSSILPFTPPIVKRLLGWKKGEQNGQEEKWCEKAVKSLVKKLKKT-GQLDELEK
:: : ::::::::.:. .:::: :::: :::::::: : .::::.
CCDS45 MHSTTPISSLFSFTSPAVKRLLGWKQGD---EEEKWAEKAVDSLVKKLKKKKGAMDELER
10 20 30 40 50
60 70 80 90 100 110
pF1KB8 AITTQNVNTKCITIPRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELRAMELCEFAF
:.. . .::.:::::::::::::::::::::::::.::::::.:::::. .: ::: :
CCDS45 ALSCPGQPSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPF
60 70 80 90 100 110
120 130 140 150 160
pF1KB8 NMKKDEVCVNPYHYQRVETPVLPPVLVPRHTEIPAEFPPLDDYS----HS---IPENTNF
. :. :::.:::::.:::::::::::::::.: .. : . :: .:.:...
CCDS45 GSKQKEVCINPYHYRRVETPVLPPVLVPRHSEYNPQLSLLAKFRSASLHSEPLMPHNATY
120 130 140 150 160 170
170 180 190 200
pF1KB8 PAGIE--PQSNIPETP-------P--------PGYLSEDGETSDHQMN------HSMDAG
: ... : : .: .: : :: :: .:... :. .:
CCDS45 PDSFQQPPCSALPPSPSHAFSQSPCTASYPHSPGSPSEPESPYQHSVDTPPLPYHATEA-
180 190 200 210 220 230
210 220 230 240 250
pF1KB8 SPNLSPNPMSPAHN--------NLDLQPVTYCEPAFWCSISYYELNQRVGETFHASQPSM
: . : .:.. . . : :..:: : :: :::..:::::.::::::.::. :.
CCDS45 SETQSGQPVDATADRHVVLSIPNGDFRPVCYEEPQHWCSVAYYELNNRVGETFQASSRSV
240 250 260 270 280 290
260 270 280 290 300 310
pF1KB8 TVDGFTDPSNSE-RFCLGLLSNVNRNAAVELTRRHIGRGVRLYYIGGEVFAECLSDSAIF
.::::::::.. :::::::::::::...: ::::::.::.:::.::::.:::.:::.::
CCDS45 LIDGFTDPSNNRNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECVSDSSIF
300 310 320 330 340 350
320 330 340 350 360 370
pF1KB8 VQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRM
::: ::: ..:.::::::::: ::.::.:::: :: ::::::..:::.::.::.::::::
CCDS45 VQSRNCNYQHGFHPATVCKIPSGCSLKVFNNQLFAQLLAQSVHHGFEVVYELTKMCTIRM
360 370 380 390 400 410
380 390 400 410 420
pF1KB8 SFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSIRCSSVS
::::::::::.:: :::::::::.::.:::::::::::::::: ::::
CCDS45 SFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS
420 430 440 450 460
>>CCDS11950.1 SMAD4 gene_id:4089|Hs108|chr18 (552 aa)
initn: 766 init1: 229 opt: 472 Z-score: 426.4 bits: 88.3 E(32554): 2e-17
Smith-Waterman score: 782; 39.1% identity (60.5% similar) in 425 aa overlap (11-344:19-439)
10 20 30 40 50
pF1KB8 MSSILPFTPPIVKRLLGWKKGEQNGQEEKWCEKAVKSLVKKLK-KTGQLDEL
::. :. ..: :. : . ..:..::::::: : .:: :
CCDS11 MDNMSITNTPTSNDACLSIVHSLMCHRQG---GESETFAKRAIESLVKKLKEKKDELDSL
10 20 30 40 50
60 70 80 90 100 110
pF1KB8 EKAITTQNVN-TKCITIPRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELRAMELCE
::::.... .::.:: :.:::::::. :::.::::: :::::::::.. ::. .. :.
CCDS11 ITAITTNGAHPSKCVTIQRTLDGRLQVAGRKGFPHVIYARLWRWPDLHKN-ELKHVKYCQ
60 70 80 90 100 110
120 130 140 150
pF1KB8 FAFNMKKDEVCVNPYHYQRVETPVLPPVLVPRHTEIPA------EF-------PPLDDYS
.::..: : ::::::::.:: .: . . ... :. :. : :. .
CCDS11 YAFDLKCDSVCVNPYHYERVVSPGIDLSGLTLQSNAPSSMMVKDEYVHDFEGQPSLSTEG
120 130 140 150 160 170
160 170 180
pF1KB8 HSI------PENT------NFPAGIEPQ-------SNIPETP------PPGYL----SE-
::: : : . :: . :. .:.:. : : . : ::
CCDS11 HSIQTIQHPPSNRASTETYSTPALLAPSESNATSTANFPNIPVASTSQPASILGGSHSEG
180 190 200 210 220 230
190 200
pF1KB8 -----DGETSDHQMN----------HSMDA---GS------PNLS--------------P
.: .:.: :. . :: ::: :
CCDS11 LLQIASGPQPGQQQNGFTGQPATYHHNSTTTWTGSRTAPYTPNLPHHQNGHLQHHPPMPP
240 250 260 270 280 290
210 220 230 240 250 260
pF1KB8 NPMS--PAHNNLDLQPVTYCEPA--FWCSISYYELNQRVGETFH--ASQPSMTVDGFTDP
.: :.::.: .:: .:: .::::.:.:.. .:::::. .: : .::::..::
CCDS11 HPGHYWPVHNELAFQPPISNHPAPEYWCSIAYFEMDVQVGETFKVPSSCPIVTVDGYVDP
300 310 320 330 340 350
270 280 290 300 310 320
pF1KB8 SNSERFCLGLLSNVNRNAAVELTRRHIGRGVRLYYIG-GEVFAECLSDSAIFVQSPNCNQ
:...::::: ::::.:. :.: .: :::.::.: : :.:...:::: :.:::: ..
CCDS11 SGGDRFCLGQLSNVHRTEAIERARLHIGKGVQLECKGEGDVWVRCLSDHAVFVQSYYLDR
360 370 380 390 400 410
330 340 350 360 370 380
pF1KB8 RYGWHPA-TVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWG
. : :. .: :: :. .:.:.
CCDS11 EAGRAPGDAVHKIYPSAYIKVFDLRQCHRQMQQQAATAQAAAAAQAAAVAGNIPGPGSVG
420 430 440 450 460 470
425 residues in 1 query sequences
18511270 residues in 32554 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 10:22:46 2016 done: Fri Nov 4 10:22:47 2016
Total Scan time: 2.160 Total Display time: 0.040
Function used was FASTA [36.3.4 Apr, 2011]