FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8210, 376 aa 1>>>pF1KB8210 376 - 376 aa - 376 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.3929+/-0.000914; mu= 15.8066+/- 0.054 mean_var=63.2928+/-13.049, 0's: 0 Z-trim(103.7): 32 B-trim: 0 in 0/50 Lambda= 0.161212 statistics sampled from 7497 (7520) to 7497 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.608), E-opt: 0.2 (0.231), width: 16 Scan time: 1.690 The best scores are: opt bits E(32554) CCDS1277.1 NME7 gene_id:29922|Hs108|chr1 ( 376) 2516 594.1 6.6e-170 CCDS44274.1 NME7 gene_id:29922|Hs108|chr1 ( 340) 2265 535.7 2.3e-152 CCDS4197.1 NME5 gene_id:8382|Hs108|chr5 ( 212) 397 101.2 9.1e-22 CCDS77734.1 NME6 gene_id:10201|Hs108|chr3 ( 186) 317 82.5 3.2e-16 CCDS2763.1 NME6 gene_id:10201|Hs108|chr3 ( 194) 317 82.5 3.4e-16 CCDS3099.1 NME9 gene_id:347736|Hs108|chr3 ( 263) 278 73.5 2.4e-13 CCDS5452.1 NME8 gene_id:51314|Hs108|chr7 ( 588) 273 72.5 1.1e-12 CCDS82767.1 NME6 gene_id:10201|Hs108|chr3 ( 141) 261 69.5 2.1e-12 CCDS10443.1 NME3 gene_id:4832|Hs108|chr16 ( 169) 250 66.9 1.5e-11 CCDS10408.1 NME4 gene_id:4833|Hs108|chr16 ( 187) 250 67.0 1.6e-11 CCDS11579.1 NME1 gene_id:4830|Hs108|chr17 ( 152) 245 65.8 3e-11 CCDS11578.1 NME1 gene_id:4830|Hs108|chr17 ( 177) 245 65.8 3.4e-11 CCDS11580.1 NME2 gene_id:4831|Hs108|chr17 ( 152) 243 65.3 4.1e-11 >>CCDS1277.1 NME7 gene_id:29922|Hs108|chr1 (376 aa) initn: 2516 init1: 2516 opt: 2516 Z-score: 3163.9 bits: 594.1 E(32554): 6.6e-170 Smith-Waterman score: 2516; 100.0% identity (100.0% similar) in 376 aa overlap (1-376:1-376) 10 20 30 40 50 60 pF1KB8 MNHSERFVFIAEWYDPNASLLRRYELLFYPGDGSVEMHDVKNHRTFLKRTKYDNLHLEDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 MNHSERFVFIAEWYDPNASLLRRYELLFYPGDGSVEMHDVKNHRTFLKRTKYDNLHLEDL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 FIGNKVNVFSRQLVLIDYGDQYTARQLGSRKEKTLALIKPDAISKAGEIIEIINKAGFTI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 FIGNKVNVFSRQLVLIDYGDQYTARQLGSRKEKTLALIKPDAISKAGEIIEIINKAGFTI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 TKLKMMMLSRKEALDFHVDHQSRPFFNELIQFITTGPIIAMEILRDDAICEWKRLLGPAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 TKLKMMMLSRKEALDFHVDHQSRPFFNELIQFITTGPIIAMEILRDDAICEWKRLLGPAN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 SGVARTDASESIRALFGTDGIRNAAHGPDSFASAAREMELFFPSSGGCGPANTAKFTNCT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 SGVARTDASESIRALFGTDGIRNAAHGPDSFASAAREMELFFPSSGGCGPANTAKFTNCT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 CCIVKPHAVSEGLLGKILMAIRDAGFEISAMQMFNMDRVNVEEFYEVYKGVVTEYHDMVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 CCIVKPHAVSEGLLGKILMAIRDAGFEISAMQMFNMDRVNVEEFYEVYKGVVTEYHDMVT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 EMYSGPCVAMEIQQNNATKTFREFCGPADPEIARHLRPGTLRAIFGKTKIQNAVHCTDLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 EMYSGPCVAMEIQQNNATKTFREFCGPADPEIARHLRPGTLRAIFGKTKIQNAVHCTDLP 310 320 330 340 350 360 370 pF1KB8 EDGLLEVQYFFKILDN :::::::::::::::: CCDS12 EDGLLEVQYFFKILDN 370 >>CCDS44274.1 NME7 gene_id:29922|Hs108|chr1 (340 aa) initn: 2265 init1: 2265 opt: 2265 Z-score: 2849.1 bits: 535.7 E(32554): 2.3e-152 Smith-Waterman score: 2265; 100.0% identity (100.0% similar) in 340 aa overlap (37-376:1-340) 10 20 30 40 50 60 pF1KB8 FVFIAEWYDPNASLLRRYELLFYPGDGSVEMHDVKNHRTFLKRTKYDNLHLEDLFIGNKV :::::::::::::::::::::::::::::: CCDS44 MHDVKNHRTFLKRTKYDNLHLEDLFIGNKV 10 20 30 70 80 90 100 110 120 pF1KB8 NVFSRQLVLIDYGDQYTARQLGSRKEKTLALIKPDAISKAGEIIEIINKAGFTITKLKMM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 NVFSRQLVLIDYGDQYTARQLGSRKEKTLALIKPDAISKAGEIIEIINKAGFTITKLKMM 40 50 60 70 80 90 130 140 150 160 170 180 pF1KB8 MLSRKEALDFHVDHQSRPFFNELIQFITTGPIIAMEILRDDAICEWKRLLGPANSGVART :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 MLSRKEALDFHVDHQSRPFFNELIQFITTGPIIAMEILRDDAICEWKRLLGPANSGVART 100 110 120 130 140 150 190 200 210 220 230 240 pF1KB8 DASESIRALFGTDGIRNAAHGPDSFASAAREMELFFPSSGGCGPANTAKFTNCTCCIVKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 DASESIRALFGTDGIRNAAHGPDSFASAAREMELFFPSSGGCGPANTAKFTNCTCCIVKP 160 170 180 190 200 210 250 260 270 280 290 300 pF1KB8 HAVSEGLLGKILMAIRDAGFEISAMQMFNMDRVNVEEFYEVYKGVVTEYHDMVTEMYSGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 HAVSEGLLGKILMAIRDAGFEISAMQMFNMDRVNVEEFYEVYKGVVTEYHDMVTEMYSGP 220 230 240 250 260 270 310 320 330 340 350 360 pF1KB8 CVAMEIQQNNATKTFREFCGPADPEIARHLRPGTLRAIFGKTKIQNAVHCTDLPEDGLLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 CVAMEIQQNNATKTFREFCGPADPEIARHLRPGTLRAIFGKTKIQNAVHCTDLPEDGLLE 280 290 300 310 320 330 370 pF1KB8 VQYFFKILDN :::::::::: CCDS44 VQYFFKILDN 340 >>CCDS4197.1 NME5 gene_id:8382|Hs108|chr5 (212 aa) initn: 418 init1: 397 opt: 397 Z-score: 504.3 bits: 101.2 E(32554): 9.1e-22 Smith-Waterman score: 397; 44.7% identity (75.0% similar) in 132 aa overlap (92-223:13-144) 70 80 90 100 110 120 pF1KB8 IGNKVNVFSRQLVLIDYGDQYTARQLGSRKEKTLALIKPDAISKAGEIIEIINKAGFTIT :::::.:::: ..: :: .:: ..::::. CCDS41 MEISMPPPQIYVEKTLAIIKPDIVDKEEEIQDIILRSGFTIV 10 20 30 40 130 140 150 160 170 180 pF1KB8 KLKMMMLSRKEALDFHVDHQSRPFFNELIQFITTGPIIAMEILRDDAICEWKRLLGPANS . . . :: .. .:.:.. .. :: .: ....::..:: . : :: : .:::: :: CCDS41 QRRKLRLSPEQCSNFYVEKYGKMFFPNLTAYMSSGPLVAMILARHKAISYWLELLGPNNS 50 60 70 80 90 100 190 200 210 220 230 240 pF1KB8 GVARTDASESIRALFGTDGIRNAAHGPDSFASAAREMELFFPSSGGCGPANTAKFTNCTC ::. .:.::..::: .::: :: ..::.: ::....:: CCDS41 LVAKETHPDSLRAIYGTDDLRNALHGSNDFAAAEREIRFMFPEVIVEPIPIGQAAKDYLN 110 120 130 140 150 160 250 260 270 280 290 300 pF1KB8 CIVKPHAVSEGLLGKILMAIRDAGFEISAMQMFNMDRVNVEEFYEVYKGVVTEYHDMVTE CCDS41 LHIMPTLLEGLTELCKQKPADPLIWLADWLLKNNPNKPKLCHHPIVEEPY 170 180 190 200 210 >>CCDS77734.1 NME6 gene_id:10201|Hs108|chr3 (186 aa) initn: 315 init1: 253 opt: 317 Z-score: 404.6 bits: 82.5 E(32554): 3.2e-16 Smith-Waterman score: 317; 38.1% identity (68.7% similar) in 134 aa overlap (94-223:14-146) 70 80 90 100 110 pF1KB8 NKVNVFSRQLVLIDYGDQYTARQLGSRKEKTLALIKPDAISKAGEIIEIINKA----GFT :::::::::... :.: ... : CCDS77 MASILRSPQALQLTLALIKPDAVAHP-LILEAVHQQILSNKFL 10 20 30 40 120 130 140 150 160 170 pF1KB8 ITKLKMMMLSRKEALDFHVDHQSRPFFNELIQFITTGPIIAMEILRDDAICEWKRLLGPA :.... .. ... :. .:..: :...:..:...::: :. . . ::: :. :.::. CCDS77 IVRMRELLWRKEDCQRFYREHEGRFFYQRLVEFMASGPIRAYILAHKDAIQLWRTLMGPT 50 60 70 80 90 100 180 190 200 210 220 230 pF1KB8 NSGVARTDASESIRALFGTDGIRNAAHGPDSFASAAREMELFFPSSGGCGPANTAKFTNC :: : .:::. :: ::..:: :: .::.::. ::: CCDS77 RVFRARHVAPDSIRGSFGLTDTRNTTHGSDSVVSASREIAAFFPDFSEQRWYEEEEPQLR 110 120 130 140 150 160 240 250 260 270 280 290 pF1KB8 TCCIVKPHAVSEGLLGKILMAIRDAGFEISAMQMFNMDRVNVEEFYEVYKGVVTEYHDMV CCDS77 CGPVCYSPEGGVHYVAGTGGLGPA 170 180 >>CCDS2763.1 NME6 gene_id:10201|Hs108|chr3 (194 aa) initn: 298 init1: 253 opt: 317 Z-score: 404.3 bits: 82.5 E(32554): 3.4e-16 Smith-Waterman score: 317; 38.1% identity (68.7% similar) in 134 aa overlap (94-223:22-154) 70 80 90 100 110 pF1KB8 NKVNVFSRQLVLIDYGDQYTARQLGSRKEKTLALIKPDAISKAGEIIEIINKA----GFT :::::::::... :.: ... : CCDS27 MTQNLGSEMASILRSPQALQLTLALIKPDAVAHP-LILEAVHQQILSNKFL 10 20 30 40 50 120 130 140 150 160 170 pF1KB8 ITKLKMMMLSRKEALDFHVDHQSRPFFNELIQFITTGPIIAMEILRDDAICEWKRLLGPA :.... .. ... :. .:..: :...:..:...::: :. . . ::: :. :.::. CCDS27 IVRMRELLWRKEDCQRFYREHEGRFFYQRLVEFMASGPIRAYILAHKDAIQLWRTLMGPT 60 70 80 90 100 110 180 190 200 210 220 230 pF1KB8 NSGVARTDASESIRALFGTDGIRNAAHGPDSFASAAREMELFFPSSGGCGPANTAKFTNC :: : .:::. :: ::..:: :: .::.::. ::: CCDS27 RVFRARHVAPDSIRGSFGLTDTRNTTHGSDSVVSASREIAAFFPDFSEQRWYEEEEPQLR 120 130 140 150 160 170 240 250 260 270 280 290 pF1KB8 TCCIVKPHAVSEGLLGKILMAIRDAGFEISAMQMFNMDRVNVEEFYEVYKGVVTEYHDMV CCDS27 CGPVCYSPEGGVHYVAGTGGLGPA 180 190 >>CCDS3099.1 NME9 gene_id:347736|Hs108|chr3 (263 aa) initn: 271 init1: 169 opt: 278 Z-score: 353.2 bits: 73.5 E(32554): 2.4e-13 Smith-Waterman score: 278; 31.2% identity (62.4% similar) in 173 aa overlap (60-224:64-236) 30 40 50 60 70 80 pF1KB8 PGDGSVEMHDVKNHRTFLKRTKYDNLHLEDLFIGNKVNVFSRQLVLIDYGDQYTARQ--L :: . : ...: . ...: . . . CCDS30 VGLDLLHFALAEADRLDVLEKYRGKCEPTFLFYAIKDEALSDEDECVSHGKNNGEDEDMV 40 50 60 70 80 90 90 100 110 120 130 140 pF1KB8 GSRKEKTLALIKPDAIS--KAGEIIEIINKAGFTITKLKMMMLSRKEALDFHVDHQSRPF .:.. :::.:::::.. :. ::: :..::: : . ... :. :. . .. CCDS30 SSERTCTLAIIKPDAVAHGKTDEIIMKIQEAGFEILTNEERTMTEAEVRLFYQHKAGEEA 100 110 120 130 140 150 150 160 170 180 190 200 pF1KB8 FNELIQFITTGPIIAMEILR----DDAICEWKRLLGPANSGVARTDASESIRALFGTDGI :..:.. . .:: . . : .:.. :. ..:: . .::: . ::.:: .::. CCDS30 FEKLVHHMCSGPSHLLILTRTEGFEDVVTTWRTVMGPRDPNVARREQPESLRAQYGTEMP 160 170 180 190 200 210 210 220 230 240 250 260 pF1KB8 RNAAHGPDSFASAAREMELFFPSSGGCGPANTAKFTNCTCCIVKPHAVSEGLLGKILMAI ::.:: . .: ::. :.::: CCDS30 FNAVHGSRDREDADRELALLFPSLKFSDKDTEAPQGESSTQPRLKITDLD 220 230 240 250 260 >>CCDS5452.1 NME8 gene_id:51314|Hs108|chr7 (588 aa) initn: 443 init1: 233 opt: 273 Z-score: 341.5 bits: 72.5 E(32554): 1.1e-12 Smith-Waterman score: 454; 32.1% identity (63.5% similar) in 252 aa overlap (105-355:330-566) 80 90 100 110 120 130 pF1KB8 LIDYGDQYTARQLGSRKEKTLALIKPDAISKAGEIIEIINKAGFTITKLKMMMLSRKEAL . ....::. : : . ....::.::: CCDS54 MDAFFPDFKKMKSMKLEKTLALLRPNLFHERKDDVLRIIKDEDFKILEQRQVVLSEKEAQ 300 310 320 330 340 350 140 150 160 170 180 190 pF1KB8 DFHVDHQSRPFFNELIQFITTGPIIAMEILRDDAICEWKRLLGPANSGVARTDASESIRA . ..... .::.::. .:.:: .:. .:::... ::.:::: . : ::. : CCDS54 ALCKEYENEDYFNKLIENMTSGPSLALVLLRDNGLQYWKQLLGPRTVEEAIEYFPESLCA 360 370 380 390 400 410 200 210 220 230 240 250 pF1KB8 LFGTDGIR-NAAHGPDSFASAAREMELFFPSSGGCGPANTAKFTNCTCCIVKPHAVSEGL :. :.. : .: ::. .: ::.. ::: .. : ..::::.:: CCDS54 QFAMDSLPVNQLYGSDSLETAEREIQHFFPLQSTLG-------------LIKPHATSEQR 420 430 440 450 460 260 270 280 290 300 310 pF1KB8 LGKILMAIRDAGFEISAMQMFNMDRVNVEEFYEVYKGVVTEYHDMVTEMYSGPCVAMEIQ .:: ...:::... .. . . ..:..: : :.:.. . :: ..: . CCDS54 E-QILKIVKEAGFDLTQVKKMFLTPEQIEKIYPKVTGK-DFYKDLLEMLSVGPSMVMILT 470 480 490 500 510 520 320 330 340 350 360 370 pF1KB8 QNNATKTFREFCGPADPEIARHLRPGTLRAIFGKTKIQNAVHCTDLPEDGLLEVQYFFKI . ::. .:.. ::.::: :. : : ..:: :: .:..: :: CCDS54 KWNAVAEWRRLMGPTDPEEAKLLSPDSIRAQFGISKLKNIVHGASNAYEAKEVVNRLFED 530 540 550 560 570 580 pF1KB8 LDN CCDS54 PEEN >>CCDS82767.1 NME6 gene_id:10201|Hs108|chr3 (141 aa) initn: 270 init1: 253 opt: 261 Z-score: 336.1 bits: 69.5 E(32554): 2.1e-12 Smith-Waterman score: 261; 37.6% identity (69.3% similar) in 101 aa overlap (123-223:1-101) 100 110 120 130 140 150 pF1KB8 KTLALIKPDAISKAGEIIEIINKAGFTITKLKMMMLSRKEALDFHVDHQSRPFFNELIQF .. .. ... :. .:..: :...:..: CCDS82 MRELLWRKEDCQRFYREHEGRFFYQRLVEF 10 20 30 160 170 180 190 200 210 pF1KB8 ITTGPIIAMEILRDDAICEWKRLLGPANSGVARTDASESIRALFGTDGIRNAAHGPDSFA ...::: :. . . ::: :. :.::. :: : .:::. :: ::..:: :: . CCDS82 MASGPIRAYILAHKDAIQLWRTLMGPTRVFRARHVAPDSIRGSFGLTDTRNTTHGSDSVV 40 50 60 70 80 90 220 230 240 250 260 270 pF1KB8 SAAREMELFFPSSGGCGPANTAKFTNCTCCIVKPHAVSEGLLGKILMAIRDAGFEISAMQ ::.::. ::: CCDS82 SASREIAAFFPDFSEQRWYEEEEPQLRCGPVCYSPEGGVHYVAGTGGLGPA 100 110 120 130 140 >>CCDS10443.1 NME3 gene_id:4832|Hs108|chr16 (169 aa) initn: 216 init1: 136 opt: 250 Z-score: 321.0 bits: 66.9 E(32554): 1.5e-11 Smith-Waterman score: 250; 30.1% identity (65.4% similar) in 153 aa overlap (73-222:4-151) 50 60 70 80 90 100 pF1KB8 HRTFLKRTKYDNLHLEDLFIGNKVNVFSRQLVLIDYGDQYTARQLGSRKEKTLALIKPDA ::: ... . : :.. :.:. .:::. CCDS10 MICLVLTIFANLFPAACTGAH-ERTFLAVKPDG 10 20 30 110 120 130 140 150 160 pF1KB8 ISK--AGEIIEIINKAGFTITKLKMMMLSRKEALDFHVDHQSRPFFNELIQFITTGPIIA ... .:::.. ... :: .. ::... :.. . ... . :::...:......::..: CCDS10 VQRRLVGEIVRRFERKGFKLVALKLVQASEELLREHYAELRERPFYGRLVKYMASGPVVA 40 50 60 70 80 90 170 180 190 200 210 pF1KB8 MEILRDDAICEWKRLLGPANSGVARTDASE-SIRALFGTDGIRNAAHGPDSFASAAREME : :.. . :.: .: . :: .::. : . .: :: :: :: ::. CCDS10 MVWQGLDVVRTSRALIGATNPA----DAPPGTIRGDFCIEVGKNLIHGSDSVESARREIA 100 110 120 130 140 220 230 240 250 260 270 pF1KB8 LFFPSSGGCGPANTAKFTNCTCCIVKPHAVSEGLLGKILMAIRDAGFEISAMQMFNMDRV :.: CCDS10 LWFRADELLCWEDSAGHWLYE 150 160 >>CCDS10408.1 NME4 gene_id:4833|Hs108|chr16 (187 aa) initn: 249 init1: 134 opt: 250 Z-score: 320.3 bits: 67.0 E(32554): 1.6e-11 Smith-Waterman score: 250; 29.9% identity (68.6% similar) in 137 aa overlap (91-225:37-170) 70 80 90 100 110 pF1KB8 FIGNKVNVFSRQLVLIDYGDQYTARQLGSRKEKTLALIKPDAISK--AGEIIEIINKAGF .:.::. .:::.... .:..:. ... :: CCDS10 RSALRGLRCGPRAPGPSLLVRHGSGGPSWTRERTLVAVKPDGVQRRLVGDVIQRFERRGF 10 20 30 40 50 60 120 130 140 150 160 170 pF1KB8 TITKLKMMMLSRKEALDFHVDHQSRPFFNELIQFITTGPIIAMEILRDDAICEWKRLLGP :.. .::.. .. . . : . .::. ::.....::..:: ... . ..: CCDS10 TLVGMKMLQAPESVLAEHYQDLRRKPFYPALIRYMSSGPVVAMVWEGYNVVRASRAMIGH 70 80 90 100 110 120 180 190 200 210 220 230 pF1KB8 ANSGVARTDASESIRALFGTDGIRNAAHGPDSFASAAREMELFFPSSGGCGPANTAKFTN ..:. : : .::. :.. ::. :. :: .: ::..:.: :: CCDS10 TDSAEA---APGTIRGDFSVHISRNVIHASDSVEGAQREIQLWFQSSELVSWADGGQHSS 130 140 150 160 170 180 240 250 260 270 280 290 pF1KB8 CTCCIVKPHAVSEGLLGKILMAIRDAGFEISAMQMFNMDRVNVEEFYEVYKGVVTEYHDM CCDS10 IHPA 376 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 10:36:10 2016 done: Fri Nov 4 10:36:10 2016 Total Scan time: 1.690 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]