FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8212, 134 aa 1>>>pF1KB8212 134 - 134 aa - 134 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.5935+/-0.000285; mu= 11.0934+/- 0.018 mean_var=80.0246+/-15.780, 0's: 0 Z-trim(119.4): 30 B-trim: 50 in 1/52 Lambda= 0.143371 statistics sampled from 33460 (33490) to 33460 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.752), E-opt: 0.2 (0.393), width: 16 Scan time: 4.080 The best scores are: opt bits E(85289) XP_006714979 (OMIM: 127750,602569) PREDICTED: beta ( 134) 846 183.3 9.9e-47 NP_003076 (OMIM: 127750,602569) beta-synuclein iso ( 134) 846 183.3 9.9e-47 NP_001001502 (OMIM: 127750,602569) beta-synuclein ( 134) 846 183.3 9.9e-47 XP_006714978 (OMIM: 127750,602569) PREDICTED: beta ( 152) 781 169.9 1.2e-42 XP_011532942 (OMIM: 127750,602569) PREDICTED: beta ( 152) 781 169.9 1.2e-42 XP_006714977 (OMIM: 127750,602569) PREDICTED: beta ( 152) 781 169.9 1.2e-42 NP_001304963 (OMIM: 127750,602569) beta-synuclein ( 120) 600 132.4 1.9e-31 NP_001304965 (OMIM: 127750,602569) beta-synuclein ( 120) 600 132.4 1.9e-31 NP_001304966 (OMIM: 127750,602569) beta-synuclein ( 104) 578 127.8 3.9e-30 NP_001304964 (OMIM: 127750,602569) beta-synuclein ( 104) 578 127.8 3.9e-30 XP_016864052 (OMIM: 127750,163890,168601,605543) P ( 140) 459 103.3 1.3e-22 NP_001139526 (OMIM: 127750,163890,168601,605543) a ( 140) 459 103.3 1.3e-22 XP_016864051 (OMIM: 127750,163890,168601,605543) P ( 140) 459 103.3 1.3e-22 NP_000336 (OMIM: 127750,163890,168601,605543) alph ( 140) 459 103.3 1.3e-22 NP_001139527 (OMIM: 127750,163890,168601,605543) a ( 140) 459 103.3 1.3e-22 XP_011530510 (OMIM: 127750,163890,168601,605543) P ( 140) 459 103.3 1.3e-22 NP_009292 (OMIM: 127750,163890,168601,605543) alph ( 112) 383 87.5 5.8e-18 XP_011530507 (OMIM: 127750,163890,168601,605543) P ( 170) 383 87.6 8.1e-18 XP_011530508 (OMIM: 127750,163890,168601,605543) P ( 170) 383 87.6 8.1e-18 XP_011530506 (OMIM: 127750,163890,168601,605543) P ( 170) 383 87.6 8.1e-18 XP_011530505 (OMIM: 127750,163890,168601,605543) P ( 170) 383 87.6 8.1e-18 XP_011530509 (OMIM: 127750,163890,168601,605543) P ( 170) 383 87.6 8.1e-18 NP_003078 (OMIM: 602998) gamma-synuclein isoform 1 ( 127) 342 79.1 2.3e-15 NP_001317049 (OMIM: 602998) gamma-synuclein isofor ( 126) 266 63.4 1.2e-10 >>XP_006714979 (OMIM: 127750,602569) PREDICTED: beta-syn (134 aa) initn: 846 init1: 846 opt: 846 Z-score: 960.0 bits: 183.3 E(85289): 9.9e-47 Smith-Waterman score: 846; 100.0% identity (100.0% similar) in 134 aa overlap (1-134:1-134) 10 20 30 40 50 60 pF1KB8 MDVFMKGLSMAKEGVVAAAEKTKQGVTEAAEKTKEGVLYVGSKTREGVVQGVASVAEKTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MDVFMKGLSMAKEGVVAAAEKTKQGVTEAAEKTKEGVLYVGSKTREGVVQGVASVAEKTK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 EQASHLGGAVFSGAGNIAAATGLVKREEFPTDLKPEEVAQEAAEEPLIEPLMEPEGESYE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EQASHLGGAVFSGAGNIAAATGLVKREEFPTDLKPEEVAQEAAEEPLIEPLMEPEGESYE 70 80 90 100 110 120 130 pF1KB8 DPPQEEYQEYEPEA :::::::::::::: XP_006 DPPQEEYQEYEPEA 130 >>NP_003076 (OMIM: 127750,602569) beta-synuclein isoform (134 aa) initn: 846 init1: 846 opt: 846 Z-score: 960.0 bits: 183.3 E(85289): 9.9e-47 Smith-Waterman score: 846; 100.0% identity (100.0% similar) in 134 aa overlap (1-134:1-134) 10 20 30 40 50 60 pF1KB8 MDVFMKGLSMAKEGVVAAAEKTKQGVTEAAEKTKEGVLYVGSKTREGVVQGVASVAEKTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 MDVFMKGLSMAKEGVVAAAEKTKQGVTEAAEKTKEGVLYVGSKTREGVVQGVASVAEKTK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 EQASHLGGAVFSGAGNIAAATGLVKREEFPTDLKPEEVAQEAAEEPLIEPLMEPEGESYE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 EQASHLGGAVFSGAGNIAAATGLVKREEFPTDLKPEEVAQEAAEEPLIEPLMEPEGESYE 70 80 90 100 110 120 130 pF1KB8 DPPQEEYQEYEPEA :::::::::::::: NP_003 DPPQEEYQEYEPEA 130 >>NP_001001502 (OMIM: 127750,602569) beta-synuclein isof (134 aa) initn: 846 init1: 846 opt: 846 Z-score: 960.0 bits: 183.3 E(85289): 9.9e-47 Smith-Waterman score: 846; 100.0% identity (100.0% similar) in 134 aa overlap (1-134:1-134) 10 20 30 40 50 60 pF1KB8 MDVFMKGLSMAKEGVVAAAEKTKQGVTEAAEKTKEGVLYVGSKTREGVVQGVASVAEKTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MDVFMKGLSMAKEGVVAAAEKTKQGVTEAAEKTKEGVLYVGSKTREGVVQGVASVAEKTK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 EQASHLGGAVFSGAGNIAAATGLVKREEFPTDLKPEEVAQEAAEEPLIEPLMEPEGESYE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EQASHLGGAVFSGAGNIAAATGLVKREEFPTDLKPEEVAQEAAEEPLIEPLMEPEGESYE 70 80 90 100 110 120 130 pF1KB8 DPPQEEYQEYEPEA :::::::::::::: NP_001 DPPQEEYQEYEPEA 130 >>XP_006714978 (OMIM: 127750,602569) PREDICTED: beta-syn (152 aa) initn: 778 init1: 778 opt: 781 Z-score: 886.5 bits: 169.9 E(85289): 1.2e-42 Smith-Waterman score: 781; 96.9% identity (98.4% similar) in 129 aa overlap (1-129:1-129) 10 20 30 40 50 60 pF1KB8 MDVFMKGLSMAKEGVVAAAEKTKQGVTEAAEKTKEGVLYVGSKTREGVVQGVASVAEKTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MDVFMKGLSMAKEGVVAAAEKTKQGVTEAAEKTKEGVLYVGSKTREGVVQGVASVAEKTK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 EQASHLGGAVFSGAGNIAAATGLVKREEFPTDLKPEEVAQEAAEEPLIEPLMEPEGESYE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EQASHLGGAVFSGAGNIAAATGLVKREEFPTDLKPEEVAQEAAEEPLIEPLMEPEGESYE 70 80 90 100 110 120 130 pF1KB8 DPPQEEYQEYEPEA :::: . :. XP_006 DPPQVRGQQGWAGLWESRMIAAVPSWGGTSLA 130 140 150 >>XP_011532942 (OMIM: 127750,602569) PREDICTED: beta-syn (152 aa) initn: 778 init1: 778 opt: 781 Z-score: 886.5 bits: 169.9 E(85289): 1.2e-42 Smith-Waterman score: 781; 96.9% identity (98.4% similar) in 129 aa overlap (1-129:1-129) 10 20 30 40 50 60 pF1KB8 MDVFMKGLSMAKEGVVAAAEKTKQGVTEAAEKTKEGVLYVGSKTREGVVQGVASVAEKTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MDVFMKGLSMAKEGVVAAAEKTKQGVTEAAEKTKEGVLYVGSKTREGVVQGVASVAEKTK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 EQASHLGGAVFSGAGNIAAATGLVKREEFPTDLKPEEVAQEAAEEPLIEPLMEPEGESYE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EQASHLGGAVFSGAGNIAAATGLVKREEFPTDLKPEEVAQEAAEEPLIEPLMEPEGESYE 70 80 90 100 110 120 130 pF1KB8 DPPQEEYQEYEPEA :::: . :. XP_011 DPPQVRGQQGWAGLWESRMIAAVPSWGGTSLA 130 140 150 >>XP_006714977 (OMIM: 127750,602569) PREDICTED: beta-syn (152 aa) initn: 778 init1: 778 opt: 781 Z-score: 886.5 bits: 169.9 E(85289): 1.2e-42 Smith-Waterman score: 781; 96.9% identity (98.4% similar) in 129 aa overlap (1-129:1-129) 10 20 30 40 50 60 pF1KB8 MDVFMKGLSMAKEGVVAAAEKTKQGVTEAAEKTKEGVLYVGSKTREGVVQGVASVAEKTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MDVFMKGLSMAKEGVVAAAEKTKQGVTEAAEKTKEGVLYVGSKTREGVVQGVASVAEKTK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 EQASHLGGAVFSGAGNIAAATGLVKREEFPTDLKPEEVAQEAAEEPLIEPLMEPEGESYE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EQASHLGGAVFSGAGNIAAATGLVKREEFPTDLKPEEVAQEAAEEPLIEPLMEPEGESYE 70 80 90 100 110 120 130 pF1KB8 DPPQEEYQEYEPEA :::: . :. XP_006 DPPQVRGQQGWAGLWESRMIAAVPSWGGTSLA 130 140 150 >>NP_001304963 (OMIM: 127750,602569) beta-synuclein isof (120 aa) initn: 747 init1: 521 opt: 600 Z-score: 685.7 bits: 132.4 E(85289): 1.9e-31 Smith-Waterman score: 723; 89.6% identity (89.6% similar) in 134 aa overlap (1-134:1-120) 10 20 30 40 50 60 pF1KB8 MDVFMKGLSMAKEGVVAAAEKTKQGVTEAAEKTKEGVLYVGSKTREGVVQGVASVAEKTK :::::::::::::::::::::::::::::::::::::::: :::::: NP_001 MDVFMKGLSMAKEGVVAAAEKTKQGVTEAAEKTKEGVLYV--------------VAEKTK 10 20 30 40 70 80 90 100 110 120 pF1KB8 EQASHLGGAVFSGAGNIAAATGLVKREEFPTDLKPEEVAQEAAEEPLIEPLMEPEGESYE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EQASHLGGAVFSGAGNIAAATGLVKREEFPTDLKPEEVAQEAAEEPLIEPLMEPEGESYE 50 60 70 80 90 100 130 pF1KB8 DPPQEEYQEYEPEA :::::::::::::: NP_001 DPPQEEYQEYEPEA 110 120 >>NP_001304965 (OMIM: 127750,602569) beta-synuclein isof (120 aa) initn: 747 init1: 521 opt: 600 Z-score: 685.7 bits: 132.4 E(85289): 1.9e-31 Smith-Waterman score: 723; 89.6% identity (89.6% similar) in 134 aa overlap (1-134:1-120) 10 20 30 40 50 60 pF1KB8 MDVFMKGLSMAKEGVVAAAEKTKQGVTEAAEKTKEGVLYVGSKTREGVVQGVASVAEKTK :::::::::::::::::::::::::::::::::::::::: :::::: NP_001 MDVFMKGLSMAKEGVVAAAEKTKQGVTEAAEKTKEGVLYV--------------VAEKTK 10 20 30 40 70 80 90 100 110 120 pF1KB8 EQASHLGGAVFSGAGNIAAATGLVKREEFPTDLKPEEVAQEAAEEPLIEPLMEPEGESYE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EQASHLGGAVFSGAGNIAAATGLVKREEFPTDLKPEEVAQEAAEEPLIEPLMEPEGESYE 50 60 70 80 90 100 130 pF1KB8 DPPQEEYQEYEPEA :::::::::::::: NP_001 DPPQEEYQEYEPEA 110 120 >>NP_001304966 (OMIM: 127750,602569) beta-synuclein isof (104 aa) initn: 654 init1: 578 opt: 578 Z-score: 662.0 bits: 127.8 E(85289): 3.9e-30 Smith-Waterman score: 578; 99.0% identity (99.0% similar) in 96 aa overlap (1-96:1-96) 10 20 30 40 50 60 pF1KB8 MDVFMKGLSMAKEGVVAAAEKTKQGVTEAAEKTKEGVLYVGSKTREGVVQGVASVAEKTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MDVFMKGLSMAKEGVVAAAEKTKQGVTEAAEKTKEGVLYVGSKTREGVVQGVASVAEKTK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 EQASHLGGAVFSGAGNIAAATGLVKREEFPTDLKPEEVAQEAAEEPLIEPLMEPEGESYE :::::::::::::::::::::::::::::::::: : NP_001 EQASHLGGAVFSGAGNIAAATGLVKREEFPTDLKEEYQEYEPEA 70 80 90 100 130 pF1KB8 DPPQEEYQEYEPEA >>NP_001304964 (OMIM: 127750,602569) beta-synuclein isof (104 aa) initn: 654 init1: 578 opt: 578 Z-score: 662.0 bits: 127.8 E(85289): 3.9e-30 Smith-Waterman score: 578; 99.0% identity (99.0% similar) in 96 aa overlap (1-96:1-96) 10 20 30 40 50 60 pF1KB8 MDVFMKGLSMAKEGVVAAAEKTKQGVTEAAEKTKEGVLYVGSKTREGVVQGVASVAEKTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MDVFMKGLSMAKEGVVAAAEKTKQGVTEAAEKTKEGVLYVGSKTREGVVQGVASVAEKTK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 EQASHLGGAVFSGAGNIAAATGLVKREEFPTDLKPEEVAQEAAEEPLIEPLMEPEGESYE :::::::::::::::::::::::::::::::::: : NP_001 EQASHLGGAVFSGAGNIAAATGLVKREEFPTDLKEEYQEYEPEA 70 80 90 100 130 pF1KB8 DPPQEEYQEYEPEA 134 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 10:37:16 2016 done: Fri Nov 4 10:37:17 2016 Total Scan time: 4.080 Total Display time: -0.030 Function used was FASTA [36.3.4 Apr, 2011]