Result of FASTA (omim) for
pF1KB8215
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB8215, 140 aa
1>>>pF1KB8215 140 - 140 aa - 140 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.2507+/-0.00033; mu= 7.2036+/- 0.020
mean_var=131.8653+/-27.770, 0's: 0 Z-trim(119.7): 320 B-trim: 1255 in 2/53
Lambda= 0.111689
statistics sampled from 33493 (33995) to 33493 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.775), E-opt: 0.2 (0.399), width: 16
Scan time: 4.910
The best scores are: opt bits E(85289)
XP_011529275 (OMIM: 300632) PREDICTED: PDZ domain- ( 140) 965 165.8 2.1e-41
NP_057568 (OMIM: 300632) PDZ domain-containing pro ( 140) 965 165.8 2.1e-41
XP_016885057 (OMIM: 300632) PREDICTED: PDZ domain- ( 172) 965 165.9 2.4e-41
NP_001311352 (OMIM: 603380) protein lin-7 homolog ( 162) 223 46.3 2.3e-05
XP_006723386 (OMIM: 612331) PREDICTED: protein lin ( 183) 222 46.2 2.8e-05
NP_004655 (OMIM: 603380) protein lin-7 homolog A i ( 233) 223 46.4 2.9e-05
NP_071448 (OMIM: 612331) protein lin-7 homolog B i ( 207) 222 46.2 3e-05
NP_060832 (OMIM: 612332) protein lin-7 homolog C [ ( 197) 220 45.9 3.6e-05
NP_079171 (OMIM: 276901,605472,612971) PDZ domain- ( 517) 223 46.8 5.1e-05
XP_016872157 (OMIM: 276901,605472,612971) PREDICTE ( 528) 223 46.8 5.2e-05
XP_011538485 (OMIM: 276901,605472,612971) PREDICTE ( 533) 223 46.8 5.2e-05
XP_011538484 (OMIM: 276901,605472,612971) PREDICTE ( 539) 223 46.8 5.3e-05
XP_011538483 (OMIM: 276901,605472,612971) PREDICTE ( 544) 223 46.8 5.3e-05
XP_005270222 (OMIM: 276901,605472,612971) PREDICTE ( 561) 223 46.8 5.4e-05
XP_016872156 (OMIM: 276901,605472,612971) PREDICTE ( 573) 223 46.8 5.5e-05
XP_011538481 (OMIM: 276901,605472,612971) PREDICTE ( 677) 223 46.9 6.2e-05
XP_011538480 (OMIM: 276901,605472,612971) PREDICTE (1032) 223 47.1 8.3e-05
XP_011538479 (OMIM: 276901,605472,612971) PREDICTE (1033) 223 47.1 8.3e-05
NP_001182192 (OMIM: 276901,605472,612971) PDZ doma (1033) 223 47.1 8.3e-05
XP_011516796 (OMIM: 607084,607928,611383) PREDICTE ( 556) 217 45.8 0.0001
XP_011516793 (OMIM: 607084,607928,611383) PREDICTE ( 571) 217 45.9 0.00011
XP_011516794 (OMIM: 607084,607928,611383) PREDICTE ( 571) 217 45.9 0.00011
XP_011516791 (OMIM: 607084,607928,611383) PREDICTE ( 577) 217 45.9 0.00011
XP_011516790 (OMIM: 607084,607928,611383) PREDICTE ( 837) 217 46.0 0.00014
NP_001166896 (OMIM: 607084,607928,611383) whirlin ( 906) 217 46.1 0.00015
NP_056219 (OMIM: 607084,607928,611383) whirlin iso ( 907) 217 46.1 0.00015
XP_011516788 (OMIM: 607084,607928,611383) PREDICTE ( 917) 217 46.1 0.00015
XP_011516787 (OMIM: 607084,607928,611383) PREDICTE ( 918) 217 46.1 0.00015
XP_011516786 (OMIM: 607084,607928,611383) PREDICTE ( 918) 217 46.1 0.00015
XP_016861313 (OMIM: 601014) PREDICTED: disks large ( 519) 200 43.1 0.00067
XP_011510811 (OMIM: 601014) PREDICTED: disks large ( 554) 200 43.1 0.0007
NP_001191317 (OMIM: 601014) disks large homolog 1 ( 788) 200 43.3 0.00089
NP_001191316 (OMIM: 601014) disks large homolog 1 ( 800) 200 43.3 0.0009
XP_016861312 (OMIM: 601014) PREDICTED: disks large ( 810) 200 43.3 0.00091
XP_016861311 (OMIM: 601014) PREDICTED: disks large ( 821) 200 43.3 0.00092
XP_016861310 (OMIM: 601014) PREDICTED: disks large ( 843) 200 43.3 0.00094
XP_016861309 (OMIM: 601014) PREDICTED: disks large ( 853) 200 43.3 0.00094
XP_011510808 (OMIM: 601014) PREDICTED: disks large ( 853) 200 43.3 0.00094
XP_011510807 (OMIM: 601014) PREDICTED: disks large ( 871) 200 43.3 0.00096
XP_016861305 (OMIM: 601014) PREDICTED: disks large ( 871) 200 43.3 0.00096
XP_016861307 (OMIM: 601014) PREDICTED: disks large ( 871) 200 43.3 0.00096
XP_016861306 (OMIM: 601014) PREDICTED: disks large ( 871) 200 43.3 0.00096
XP_016861308 (OMIM: 601014) PREDICTED: disks large ( 871) 200 43.3 0.00096
XP_016861304 (OMIM: 601014) PREDICTED: disks large ( 874) 200 43.3 0.00096
XP_016861301 (OMIM: 601014) PREDICTED: disks large ( 875) 200 43.3 0.00096
XP_016861300 (OMIM: 601014) PREDICTED: disks large ( 875) 200 43.3 0.00096
XP_016861303 (OMIM: 601014) PREDICTED: disks large ( 875) 200 43.3 0.00096
XP_016861302 (OMIM: 601014) PREDICTED: disks large ( 875) 200 43.3 0.00096
XP_016861299 (OMIM: 601014) PREDICTED: disks large ( 892) 200 43.3 0.00097
XP_011510805 (OMIM: 601014) PREDICTED: disks large ( 892) 200 43.3 0.00097
>>XP_011529275 (OMIM: 300632) PREDICTED: PDZ domain-cont (140 aa)
initn: 965 init1: 965 opt: 965 Z-score: 864.4 bits: 165.8 E(85289): 2.1e-41
Smith-Waterman score: 965; 100.0% identity (100.0% similar) in 140 aa overlap (1-140:1-140)
10 20 30 40 50 60
pF1KB8 MDSRIPYDDYPVVFLPAYENPPAWIPPHERVHHPDYNNELTQFLPRTITLKKPPGAQLGF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MDSRIPYDDYPVVFLPAYENPPAWIPPHERVHHPDYNNELTQFLPRTITLKKPPGAQLGF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 NIRGGKASQLGIFISKVIPDSDAHRAGLQEGDQVLAVNDVDFQDIEHSKAVEILKTAREI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NIRGGKASQLGIFISKVIPDSDAHRAGLQEGDQVLAVNDVDFQDIEHSKAVEILKTAREI
70 80 90 100 110 120
130 140
pF1KB8 SMRVRFFPYNYHRQKERTVH
::::::::::::::::::::
XP_011 SMRVRFFPYNYHRQKERTVH
130 140
>>NP_057568 (OMIM: 300632) PDZ domain-containing protein (140 aa)
initn: 965 init1: 965 opt: 965 Z-score: 864.4 bits: 165.8 E(85289): 2.1e-41
Smith-Waterman score: 965; 100.0% identity (100.0% similar) in 140 aa overlap (1-140:1-140)
10 20 30 40 50 60
pF1KB8 MDSRIPYDDYPVVFLPAYENPPAWIPPHERVHHPDYNNELTQFLPRTITLKKPPGAQLGF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 MDSRIPYDDYPVVFLPAYENPPAWIPPHERVHHPDYNNELTQFLPRTITLKKPPGAQLGF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 NIRGGKASQLGIFISKVIPDSDAHRAGLQEGDQVLAVNDVDFQDIEHSKAVEILKTAREI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 NIRGGKASQLGIFISKVIPDSDAHRAGLQEGDQVLAVNDVDFQDIEHSKAVEILKTAREI
70 80 90 100 110 120
130 140
pF1KB8 SMRVRFFPYNYHRQKERTVH
::::::::::::::::::::
NP_057 SMRVRFFPYNYHRQKERTVH
130 140
>>XP_016885057 (OMIM: 300632) PREDICTED: PDZ domain-cont (172 aa)
initn: 965 init1: 965 opt: 965 Z-score: 863.2 bits: 165.9 E(85289): 2.4e-41
Smith-Waterman score: 965; 100.0% identity (100.0% similar) in 140 aa overlap (1-140:33-172)
10 20 30
pF1KB8 MDSRIPYDDYPVVFLPAYENPPAWIPPHER
::::::::::::::::::::::::::::::
XP_016 WSCCLKLAGLLSLLNHFLSVLIHSSRALPEMDSRIPYDDYPVVFLPAYENPPAWIPPHER
10 20 30 40 50 60
40 50 60 70 80 90
pF1KB8 VHHPDYNNELTQFLPRTITLKKPPGAQLGFNIRGGKASQLGIFISKVIPDSDAHRAGLQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VHHPDYNNELTQFLPRTITLKKPPGAQLGFNIRGGKASQLGIFISKVIPDSDAHRAGLQE
70 80 90 100 110 120
100 110 120 130 140
pF1KB8 GDQVLAVNDVDFQDIEHSKAVEILKTAREISMRVRFFPYNYHRQKERTVH
::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GDQVLAVNDVDFQDIEHSKAVEILKTAREISMRVRFFPYNYHRQKERTVH
130 140 150 160 170
>>NP_001311352 (OMIM: 603380) protein lin-7 homolog A is (162 aa)
initn: 197 init1: 111 opt: 223 Z-score: 217.4 bits: 46.3 E(85289): 2.3e-05
Smith-Waterman score: 223; 41.1% identity (72.6% similar) in 95 aa overlap (45-137:35-128)
20 30 40 50 60 70
pF1KB8 LPAYENPPAWIPPHERVHHPDYNNELTQFLPRTITLKKPPGAQLGFNIRGGKASQLGIFI
::.. : : ::::. ::: .. :.:
NP_001 ITVNGCPEFRARATAKATVAAFAASEGHSHPRVVELPKTD-EGLGFNVMGGKEQNSPIYI
10 20 30 40 50 60
80 90 100 110 120 130
pF1KB8 SKVIPDSDAHR-AGLQEGDQVLAVNDVDFQDIEHSKAVEILKTARE-ISMRVRFFPYNYH
:..:: . :.: .::..:::.:.:: :. . .: ::::.::.:.. ... ::. : .
NP_001 SRIIPGGVAERHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAAKDSVKLVVRYTPKVLE
70 80 90 100 110 120
140
pF1KB8 RQKERTVH
... :
NP_001 EMEARFEKLRTARRRQQQQLLIQQQQQQQQQQTQQNHMS
130 140 150 160
>>XP_006723386 (OMIM: 612331) PREDICTED: protein lin-7 h (183 aa)
initn: 199 init1: 109 opt: 222 Z-score: 215.9 bits: 46.2 E(85289): 2.8e-05
Smith-Waterman score: 222; 43.2% identity (70.5% similar) in 95 aa overlap (45-137:67-160)
20 30 40 50 60 70
pF1KB8 LPAYENPPAWIPPHERVHHPDYNNELTQFLPRTITLKKPPGAQLGFNIRGGKASQLGIFI
::.. : : ::::: ::: .. :.:
XP_006 ALQRVLQSRFCSAIREATVAAFTASEGHAHPRVVELPKTD-EGLGFNIMGGKEQNSPIYI
40 50 60 70 80 90
80 90 100 110 120 130
pF1KB8 SKVIPDSDAHR-AGLQEGDQVLAVNDVDFQDIEHSKAVEILKTAR-EISMRVRFFPYNYH
:.::: . : : .::..:::.:.:: :. . .: ::::.::.:. ... ::. : .
XP_006 SRVIPGGVADRHGGLKRGDQLLSVNGVSVEGEQHEKAVELLKAAQGSVKLVVRYTPRVLE
100 110 120 130 140 150
140
pF1KB8 RQKERTVH
... :
XP_006 EMEARFEKMRSARRRQQHQSYSSLESRG
160 170 180
>>NP_004655 (OMIM: 603380) protein lin-7 homolog A isofo (233 aa)
initn: 197 init1: 111 opt: 223 Z-score: 215.4 bits: 46.4 E(85289): 2.9e-05
Smith-Waterman score: 223; 41.1% identity (72.6% similar) in 95 aa overlap (45-137:106-199)
20 30 40 50 60 70
pF1KB8 LPAYENPPAWIPPHERVHHPDYNNELTQFLPRTITLKKPPGAQLGFNIRGGKASQLGIFI
::.. : : ::::. ::: .. :.:
NP_004 ITVNGCPEFRARATAKATVAAFAASEGHSHPRVVELPKTD-EGLGFNVMGGKEQNSPIYI
80 90 100 110 120 130
80 90 100 110 120 130
pF1KB8 SKVIPDSDAHR-AGLQEGDQVLAVNDVDFQDIEHSKAVEILKTARE-ISMRVRFFPYNYH
:..:: . :.: .::..:::.:.:: :. . .: ::::.::.:.. ... ::. : .
NP_004 SRIIPGGVAERHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAAKDSVKLVVRYTPKVLE
140 150 160 170 180 190
140
pF1KB8 RQKERTVH
... :
NP_004 EMEARFEKLRTARRRQQQQLLIQQQQQQQQQQTQQNHMS
200 210 220 230
>>NP_071448 (OMIM: 612331) protein lin-7 homolog B isofo (207 aa)
initn: 199 init1: 109 opt: 222 Z-score: 215.2 bits: 46.2 E(85289): 3e-05
Smith-Waterman score: 222; 43.2% identity (70.5% similar) in 95 aa overlap (45-137:91-184)
20 30 40 50 60 70
pF1KB8 LPAYENPPAWIPPHERVHHPDYNNELTQFLPRTITLKKPPGAQLGFNIRGGKASQLGIFI
::.. : : ::::: ::: .. :.:
NP_071 LDITGSAEIRAHATAKATVAAFTASEGHAHPRVVELPKTD-EGLGFNIMGGKEQNSPIYI
70 80 90 100 110
80 90 100 110 120 130
pF1KB8 SKVIPDSDAHR-AGLQEGDQVLAVNDVDFQDIEHSKAVEILKTAR-EISMRVRFFPYNYH
:.::: . : : .::..:::.:.:: :. . .: ::::.::.:. ... ::. : .
NP_071 SRVIPGGVADRHGGLKRGDQLLSVNGVSVEGEQHEKAVELLKAAQGSVKLVVRYTPRVLE
120 130 140 150 160 170
140
pF1KB8 RQKERTVH
... :
NP_071 EMEARFEKMRSARRRQQHQSYSSLESRG
180 190 200
>>NP_060832 (OMIM: 612332) protein lin-7 homolog C [Homo (197 aa)
initn: 218 init1: 107 opt: 220 Z-score: 213.7 bits: 45.9 E(85289): 3.6e-05
Smith-Waterman score: 220; 42.1% identity (71.6% similar) in 95 aa overlap (45-137:91-184)
20 30 40 50 60 70
pF1KB8 LPAYENPPAWIPPHERVHHPDYNNELTQFLPRTITLKKPPGAQLGFNIRGGKASQLGIFI
::.. : : ::::: ::: .. :.:
NP_060 VDISSSPEVRANATAKATVAAFAASEGHSHPRVVELPKTE-EGLGFNIMGGKEQNSPIYI
70 80 90 100 110
80 90 100 110 120 130
pF1KB8 SKVIPDSDAHR-AGLQEGDQVLAVNDVDFQDIEHSKAVEILKTAR-EISMRVRFFPYNYH
:..:: . : : .::..:::.:.:: :. . .: ::::.::.:. .... ::. : .
NP_060 SRIIPGGIADRHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAAQGKVKLVVRYTPKVLE
120 130 140 150 160 170
140
pF1KB8 RQKERTVH
... :
NP_060 EMESRFEKMRSAKRRQQT
180 190
>>NP_079171 (OMIM: 276901,605472,612971) PDZ domain-cont (517 aa)
initn: 244 init1: 223 opt: 223 Z-score: 211.1 bits: 46.8 E(85289): 5.1e-05
Smith-Waterman score: 223; 52.9% identity (75.0% similar) in 68 aa overlap (58-125:222-289)
30 40 50 60 70 80
pF1KB8 HERVHHPDYNNELTQFLPRTITLKKPPGAQLGFNIRGGKASQLGIFISKVIPDSDAHRAG
::::::::: :::..::: . :.. :
NP_079 EKCGSTPSDTSSEDGVRRIVHLYTTSDDFCLGFNIRGGKEFGLGIYVSKVDHGGLAEENG
200 210 220 230 240 250
90 100 110 120 130 140
pF1KB8 LQEGDQVLAVNDVDFQDIEHSKAVEILKTAREISMRVRFFPYNYHRQKERTVH
.. ::::::.: : :.:: ::.:::.:: .: . ..
NP_079 IKVGDQVLAANGVRFDDISHSQAVEVLKGQTHIMLTIKETGRYPAYKEMVSEYCWLDRLS
260 270 280 290 300 310
NP_079 NGVLQQLSPASESSSSVSSCASSAPYSSGSLPSDRMDICLGQEEPGSRGPGWGRADTAMQ
320 330 340 350 360 370
>--
initn: 208 init1: 208 opt: 211 Z-score: 200.6 bits: 44.8 E(85289): 0.00019
Smith-Waterman score: 211; 35.1% identity (64.0% similar) in 111 aa overlap (21-125:54-164)
10 20 30 40
pF1KB8 MDSRIPYDDYPVVFLPAYENPPAWI---PPHERV---HHPDYNNELTQFL
:: : : :: . : : . .
NP_079 SLSSRGHLGSDSGSTATRYLLRKQQRLLNGPPRGIRASSPMGRVILINSPIEANSDESDI
30 40 50 60 70 80
50 60 70 80 90 100
pF1KB8 PRTITLKKPPGAQLGFNIRGGKASQLGIFISKVIPDSDAHRAGLQEGDQVLAVNDVDFQD
... ..: :...:::..:::. ::::.::: :.:.:::: ::.. :: .....
NP_079 IHSVRVEKSPAGRLGFSVRGGSEHGLGIFVSKVEEGSSAERAGLCVGDKITEVNGLSLES
90 100 110 120 130 140
110 120 130 140
pF1KB8 IEHSKAVEILKTAREISMRVRFFPYNYHRQKERTVH
..::..: .. .. : ::
NP_079 TTMGSAVKVLTSSSRLHMMVRRMGRVPGIKFSKEKTTWVDVVNRRLVVEKCGSTPSDTSS
150 160 170 180 190 200
>>XP_016872157 (OMIM: 276901,605472,612971) PREDICTED: P (528 aa)
initn: 244 init1: 223 opt: 223 Z-score: 211.0 bits: 46.8 E(85289): 5.2e-05
Smith-Waterman score: 223; 52.9% identity (75.0% similar) in 68 aa overlap (58-125:222-289)
30 40 50 60 70 80
pF1KB8 HERVHHPDYNNELTQFLPRTITLKKPPGAQLGFNIRGGKASQLGIFISKVIPDSDAHRAG
::::::::: :::..::: . :.. :
XP_016 EKCGSTPSDTSSEDGVRRIVHLYTTSDDFCLGFNIRGGKEFGLGIYVSKVDHGGLAEENG
200 210 220 230 240 250
90 100 110 120 130 140
pF1KB8 LQEGDQVLAVNDVDFQDIEHSKAVEILKTAREISMRVRFFPYNYHRQKERTVH
.. ::::::.: : :.:: ::.:::.:: .: . ..
XP_016 IKVGDQVLAANGVRFDDISHSQAVEVLKGQTHIMLTIKETGRYPAYKEMVSEYCWLDRLS
260 270 280 290 300 310
XP_016 NGVLQQLSPASESSSSVSSCASSAPYSSGSLPSDRMDICLGQEEPGSRGPGWGRADTAMQ
320 330 340 350 360 370
>--
initn: 208 init1: 208 opt: 211 Z-score: 200.5 bits: 44.9 E(85289): 0.0002
Smith-Waterman score: 211; 35.1% identity (64.0% similar) in 111 aa overlap (21-125:54-164)
10 20 30 40
pF1KB8 MDSRIPYDDYPVVFLPAYENPPAWI---PPHERV---HHPDYNNELTQFL
:: : : :: . : : . .
XP_016 SLSSRGHLGSDSGSTATRYLLRKQQRLLNGPPRGIRASSPMGRVILINSPIEANSDESDI
30 40 50 60 70 80
50 60 70 80 90 100
pF1KB8 PRTITLKKPPGAQLGFNIRGGKASQLGIFISKVIPDSDAHRAGLQEGDQVLAVNDVDFQD
... ..: :...:::..:::. ::::.::: :.:.:::: ::.. :: .....
XP_016 IHSVRVEKSPAGRLGFSVRGGSEHGLGIFVSKVEEGSSAERAGLCVGDKITEVNGLSLES
90 100 110 120 130 140
110 120 130 140
pF1KB8 IEHSKAVEILKTAREISMRVRFFPYNYHRQKERTVH
..::..: .. .. : ::
XP_016 TTMGSAVKVLTSSSRLHMMVRRMGRVPGIKFSKEKTTWVDVVNRRLVVEKCGSTPSDTSS
150 160 170 180 190 200
140 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 22:00:30 2016 done: Fri Nov 4 22:00:30 2016
Total Scan time: 4.910 Total Display time: 0.000
Function used was FASTA [36.3.4 Apr, 2011]