FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8225, 142 aa 1>>>pF1KB8225 142 - 142 aa - 142 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.4913+/-0.000355; mu= 12.3341+/- 0.022 mean_var=92.8119+/-18.187, 0's: 0 Z-trim(115.1): 14 B-trim: 262 in 1/52 Lambda= 0.133129 statistics sampled from 25345 (25358) to 25345 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.666), E-opt: 0.2 (0.297), width: 16 Scan time: 4.760 The best scores are: opt bits E(85289) NP_776170 (OMIM: 609768) biogenesis of lysosome-re ( 142) 873 177.0 9.2e-45 NP_001269368 (OMIM: 609768) biogenesis of lysosome ( 141) 855 173.5 1e-43 NP_001001342 (OMIM: 609768) biogenesis of lysosome ( 99) 605 125.3 2.2e-29 NP_001269366 (OMIM: 609768) biogenesis of lysosome ( 99) 605 125.3 2.2e-29 NP_001269367 (OMIM: 609768) biogenesis of lysosome ( 99) 605 125.3 2.2e-29 XP_016871591 (OMIM: 609768) PREDICTED: biogenesis ( 114) 547 114.3 5.5e-26 NP_001269365 (OMIM: 609768) biogenesis of lysosome ( 95) 520 109.0 1.8e-24 >>NP_776170 (OMIM: 609768) biogenesis of lysosome-relate (142 aa) initn: 873 init1: 873 opt: 873 Z-score: 924.6 bits: 177.0 E(85289): 9.2e-45 Smith-Waterman score: 873; 100.0% identity (100.0% similar) in 142 aa overlap (1-142:1-142) 10 20 30 40 50 60 pF1KB8 MAAAAEGVLATRSDEPARDDAAVETAEEAKEPAEADITELCRDMFSKMATYLTGELTATS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_776 MAAAAEGVLATRSDEPARDDAAVETAEEAKEPAEADITELCRDMFSKMATYLTGELTATS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 EDYKLLENMNKLTSLKYLEMKDIAINISRNLKDLNQKYAGLQPYLDQINVIEEQVAALEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_776 EDYKLLENMNKLTSLKYLEMKDIAINISRNLKDLNQKYAGLQPYLDQINVIEEQVAALEQ 70 80 90 100 110 120 130 140 pF1KB8 AAYKLDAYSKKLEAKYKKLEKR :::::::::::::::::::::: NP_776 AAYKLDAYSKKLEAKYKKLEKR 130 140 >>NP_001269368 (OMIM: 609768) biogenesis of lysosome-rel (141 aa) initn: 853 init1: 812 opt: 855 Z-score: 905.9 bits: 173.5 E(85289): 1e-43 Smith-Waterman score: 855; 99.3% identity (99.3% similar) in 142 aa overlap (1-142:1-141) 10 20 30 40 50 60 pF1KB8 MAAAAEGVLATRSDEPARDDAAVETAEEAKEPAEADITELCRDMFSKMATYLTGELTATS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAAAAEGVLATRSDEPARDDAAVETAEEAKEPAEADITELCRDMFSKMATYLTGELTATS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 EDYKLLENMNKLTSLKYLEMKDIAINISRNLKDLNQKYAGLQPYLDQINVIEEQVAALEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EDYKLLENMNKLTSLKYLEMKDIAINISRNLKDLNQKYAGLQPYLDQINVIEEQVAALEQ 70 80 90 100 110 120 130 140 pF1KB8 AAYKLDAYSKKLEAKYKKLEKR :::::::::::: ::::::::: NP_001 AAYKLDAYSKKL-AKYKKLEKR 130 140 >>NP_001001342 (OMIM: 609768) biogenesis of lysosome-rel (99 aa) initn: 605 init1: 605 opt: 605 Z-score: 648.5 bits: 125.3 E(85289): 2.2e-29 Smith-Waterman score: 605; 100.0% identity (100.0% similar) in 99 aa overlap (44-142:1-99) 20 30 40 50 60 70 pF1KB8 DEPARDDAAVETAEEAKEPAEADITELCRDMFSKMATYLTGELTATSEDYKLLENMNKLT :::::::::::::::::::::::::::::: NP_001 MFSKMATYLTGELTATSEDYKLLENMNKLT 10 20 30 80 90 100 110 120 130 pF1KB8 SLKYLEMKDIAINISRNLKDLNQKYAGLQPYLDQINVIEEQVAALEQAAYKLDAYSKKLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SLKYLEMKDIAINISRNLKDLNQKYAGLQPYLDQINVIEEQVAALEQAAYKLDAYSKKLE 40 50 60 70 80 90 140 pF1KB8 AKYKKLEKR ::::::::: NP_001 AKYKKLEKR >>NP_001269366 (OMIM: 609768) biogenesis of lysosome-rel (99 aa) initn: 605 init1: 605 opt: 605 Z-score: 648.5 bits: 125.3 E(85289): 2.2e-29 Smith-Waterman score: 605; 100.0% identity (100.0% similar) in 99 aa overlap (44-142:1-99) 20 30 40 50 60 70 pF1KB8 DEPARDDAAVETAEEAKEPAEADITELCRDMFSKMATYLTGELTATSEDYKLLENMNKLT :::::::::::::::::::::::::::::: NP_001 MFSKMATYLTGELTATSEDYKLLENMNKLT 10 20 30 80 90 100 110 120 130 pF1KB8 SLKYLEMKDIAINISRNLKDLNQKYAGLQPYLDQINVIEEQVAALEQAAYKLDAYSKKLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SLKYLEMKDIAINISRNLKDLNQKYAGLQPYLDQINVIEEQVAALEQAAYKLDAYSKKLE 40 50 60 70 80 90 140 pF1KB8 AKYKKLEKR ::::::::: NP_001 AKYKKLEKR >>NP_001269367 (OMIM: 609768) biogenesis of lysosome-rel (99 aa) initn: 605 init1: 605 opt: 605 Z-score: 648.5 bits: 125.3 E(85289): 2.2e-29 Smith-Waterman score: 605; 100.0% identity (100.0% similar) in 99 aa overlap (44-142:1-99) 20 30 40 50 60 70 pF1KB8 DEPARDDAAVETAEEAKEPAEADITELCRDMFSKMATYLTGELTATSEDYKLLENMNKLT :::::::::::::::::::::::::::::: NP_001 MFSKMATYLTGELTATSEDYKLLENMNKLT 10 20 30 80 90 100 110 120 130 pF1KB8 SLKYLEMKDIAINISRNLKDLNQKYAGLQPYLDQINVIEEQVAALEQAAYKLDAYSKKLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SLKYLEMKDIAINISRNLKDLNQKYAGLQPYLDQINVIEEQVAALEQAAYKLDAYSKKLE 40 50 60 70 80 90 140 pF1KB8 AKYKKLEKR ::::::::: NP_001 AKYKKLEKR >>XP_016871591 (OMIM: 609768) PREDICTED: biogenesis of l (114 aa) initn: 547 init1: 547 opt: 547 Z-score: 587.4 bits: 114.3 E(85289): 5.5e-26 Smith-Waterman score: 547; 95.7% identity (97.8% similar) in 93 aa overlap (44-136:1-93) 20 30 40 50 60 70 pF1KB8 DEPARDDAAVETAEEAKEPAEADITELCRDMFSKMATYLTGELTATSEDYKLLENMNKLT :::::::::::::::::::::::::::::: XP_016 MFSKMATYLTGELTATSEDYKLLENMNKLT 10 20 30 80 90 100 110 120 130 pF1KB8 SLKYLEMKDIAINISRNLKDLNQKYAGLQPYLDQINVIEEQVAALEQAAYKLDAYSKKLE ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SLKYLEMKDIAINISRNLKDLNQKYAGLQPYLDQINVIEEQVAALEQAAYKLDAYSKKLG 40 50 60 70 80 90 140 pF1KB8 AKYKKLEKR .. XP_016 NRFYFCFDVIKTASCQHILSKHNS 100 110 >>NP_001269365 (OMIM: 609768) biogenesis of lysosome-rel (95 aa) initn: 520 init1: 520 opt: 520 Z-score: 560.5 bits: 109.0 E(85289): 1.8e-24 Smith-Waterman score: 520; 100.0% identity (100.0% similar) in 85 aa overlap (58-142:11-95) 30 40 50 60 70 80 pF1KB8 EAKEPAEADITELCRDMFSKMATYLTGELTATSEDYKLLENMNKLTSLKYLEMKDIAINI :::::::::::::::::::::::::::::: NP_001 MRLPRKSLEVATSEDYKLLENMNKLTSLKYLEMKDIAINI 10 20 30 40 90 100 110 120 130 140 pF1KB8 SRNLKDLNQKYAGLQPYLDQINVIEEQVAALEQAAYKLDAYSKKLEAKYKKLEKR ::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SRNLKDLNQKYAGLQPYLDQINVIEEQVAALEQAAYKLDAYSKKLEAKYKKLEKR 50 60 70 80 90 142 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 10:43:46 2016 done: Fri Nov 4 10:43:47 2016 Total Scan time: 4.760 Total Display time: -0.020 Function used was FASTA [36.3.4 Apr, 2011]