FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8254, 192 aa 1>>>pF1KB8254 192 - 192 aa - 192 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.3000+/-0.000347; mu= 18.9566+/- 0.022 mean_var=75.1477+/-15.439, 0's: 0 Z-trim(117.3): 403 B-trim: 1428 in 2/49 Lambda= 0.147950 statistics sampled from 28770 (29244) to 28770 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.73), E-opt: 0.2 (0.343), width: 16 Scan time: 4.600 The best scores are: opt bits E(85289) NP_008839 (OMIM: 602048) ras-related C3 botulinum ( 192) 1299 285.9 2.6e-77 NP_005043 (OMIM: 602050) ras-related C3 botulinum ( 192) 1232 271.6 5.3e-73 NP_002863 (OMIM: 602049,608203) ras-related C3 bot ( 192) 1211 267.2 1.2e-71 NP_001303236 (OMIM: 602050) ras-related C3 botulin ( 170) 994 220.8 9.6e-58 XP_006724349 (OMIM: 602049,608203) PREDICTED: ras- ( 161) 981 218.0 6.4e-57 NP_001782 (OMIM: 116952,616737) cell division cont ( 191) 945 210.4 1.5e-54 NP_001034891 (OMIM: 116952,616737) cell division c ( 191) 945 210.4 1.5e-54 NP_426359 (OMIM: 116952,616737) cell division cont ( 191) 941 209.5 2.6e-54 NP_001656 (OMIM: 179505) rho-related GTP-binding p ( 191) 936 208.5 5.5e-54 XP_005252973 (OMIM: 179505) PREDICTED: rho-related ( 191) 936 208.5 5.5e-54 XP_016873208 (OMIM: 179505) PREDICTED: rho-related ( 191) 936 208.5 5.5e-54 NP_036381 (OMIM: 605857) rho-related GTP-binding p ( 205) 831 186.1 3.2e-47 NP_061485 (OMIM: 602048) ras-related C3 botulinum ( 211) 796 178.6 5.8e-45 NP_065714 (OMIM: 607653) rho-related GTP-binding p ( 214) 791 177.6 1.2e-44 NP_001655 (OMIM: 165390) transforming protein RhoA ( 193) 735 165.6 4.6e-41 NP_001300870 (OMIM: 165390) transforming protein R ( 193) 735 165.6 4.6e-41 NP_001036144 (OMIM: 165380) rho-related GTP-bindin ( 193) 726 163.6 1.7e-40 NP_001036143 (OMIM: 165380) rho-related GTP-bindin ( 193) 726 163.6 1.7e-40 NP_786886 (OMIM: 165380) rho-related GTP-binding p ( 193) 726 163.6 1.7e-40 NP_067028 (OMIM: 606366) rho-related GTP-binding p ( 258) 715 161.4 1.1e-39 NP_004031 (OMIM: 165370) rho-related GTP-binding p ( 196) 704 159.0 4.5e-39 XP_011531028 (OMIM: 605857) PREDICTED: rho-related ( 192) 675 152.8 3.3e-37 XP_016859205 (OMIM: 605857) PREDICTED: rho-related ( 172) 672 152.1 4.8e-37 NP_055393 (OMIM: 605781) rho-related GTP-binding p ( 210) 668 151.3 9.8e-37 XP_006720277 (OMIM: 607653) PREDICTED: rho-related ( 176) 635 144.2 1.1e-34 NP_001300872 (OMIM: 165390) transforming protein R ( 187) 603 137.4 1.4e-32 NP_005431 (OMIM: 601555) rho-related GTP-binding p ( 227) 573 131.1 1.3e-30 XP_011523618 (OMIM: 601555) PREDICTED: rho-related ( 234) 573 131.1 1.3e-30 NP_005159 (OMIM: 602924) rho-related GTP-binding p ( 244) 569 130.3 2.5e-30 NP_001241667 (OMIM: 602924) rho-related GTP-bindin ( 244) 569 130.3 2.5e-30 XP_011531030 (OMIM: 605857) PREDICTED: rho-related ( 157) 558 127.7 9.5e-30 NP_001265291 (OMIM: 602037) rho-related GTP-bindin ( 191) 532 122.2 5e-28 NP_001265288 (OMIM: 602037) rho-related GTP-bindin ( 191) 532 122.2 5e-28 NP_001265289 (OMIM: 602037) rho-related GTP-bindin ( 191) 532 122.2 5e-28 NP_004301 (OMIM: 602037) rho-related GTP-binding p ( 191) 532 122.2 5e-28 NP_001265294 (OMIM: 602037) rho-related GTP-bindin ( 191) 532 122.2 5e-28 XP_011511994 (OMIM: 602037) PREDICTED: rho-related ( 191) 532 122.2 5e-28 XP_016863677 (OMIM: 602037) PREDICTED: rho-related ( 191) 532 122.2 5e-28 NP_001265296 (OMIM: 602037) rho-related GTP-bindin ( 191) 532 122.2 5e-28 XP_016863678 (OMIM: 602037) PREDICTED: rho-related ( 191) 532 122.2 5e-28 NP_001265293 (OMIM: 602037) rho-related GTP-bindin ( 191) 532 122.2 5e-28 NP_001265297 (OMIM: 602037) rho-related GTP-bindin ( 191) 532 122.2 5e-28 NP_001265298 (OMIM: 602037) rho-related GTP-bindin ( 191) 532 122.2 5e-28 NP_001265295 (OMIM: 602037) rho-related GTP-bindin ( 191) 532 122.2 5e-28 NP_001265292 (OMIM: 602037) rho-related GTP-bindin ( 191) 532 122.2 5e-28 NP_001265290 (OMIM: 602037) rho-related GTP-bindin ( 191) 532 122.2 5e-28 NP_055285 (OMIM: 609038) rho-related GTP-binding p ( 232) 495 114.4 1.4e-25 XP_011523619 (OMIM: 601555) PREDICTED: rho-related ( 206) 484 112.0 6.4e-25 NP_001300873 (OMIM: 165390) transforming protein R ( 173) 471 109.2 3.9e-24 NP_001300874 (OMIM: 165390) transforming protein R ( 112) 361 85.4 3.5e-17 >>NP_008839 (OMIM: 602048) ras-related C3 botulinum toxi (192 aa) initn: 1299 init1: 1299 opt: 1299 Z-score: 1508.9 bits: 285.9 E(85289): 2.6e-77 Smith-Waterman score: 1299; 100.0% identity (100.0% similar) in 192 aa overlap (1-192:1-192) 10 20 30 40 50 60 pF1KB8 MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_008 MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 QEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVRHHCPNTPIILVGTKLDLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_008 QEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVRHHCPNTPIILVGTKLDLR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 DDKDTIEKLKEKKLTPITYPQGLAMAKEIGAVKYLECSALTQRGLKTVFDEAIRAVLCPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_008 DDKDTIEKLKEKKLTPITYPQGLAMAKEIGAVKYLECSALTQRGLKTVFDEAIRAVLCPP 130 140 150 160 170 180 190 pF1KB8 PVKKRKRKCLLL :::::::::::: NP_008 PVKKRKRKCLLL 190 >>NP_005043 (OMIM: 602050) ras-related C3 botulinum toxi (192 aa) initn: 1268 init1: 1232 opt: 1232 Z-score: 1431.6 bits: 271.6 E(85289): 5.3e-73 Smith-Waterman score: 1232; 92.7% identity (98.4% similar) in 192 aa overlap (1-192:1-192) 10 20 30 40 50 60 pF1KB8 MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 QEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVRHHCPNTPIILVGTKLDLR ::::::::::::::::::::::::::::::::::::::::::::::.:::.::::::::: NP_005 QEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVRHHCPHTPILLVGTKLDLR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 DDKDTIEKLKEKKLTPITYPQGLAMAKEIGAVKYLECSALTQRGLKTVFDEAIRAVLCPP :::::::.:..:::.:::::::::::.:::.::::::::::::::::::::::::::::: NP_005 DDKDTIERLRDKKLAPITYPQGLAMAREIGSVKYLECSALTQRGLKTVFDEAIRAVLCPP 130 140 150 160 170 180 190 pF1KB8 PVKKRKRKCLLL :::: .:: .. NP_005 PVKKPGKKCTVF 190 >>NP_002863 (OMIM: 602049,608203) ras-related C3 botulin (192 aa) initn: 1211 init1: 1211 opt: 1211 Z-score: 1407.4 bits: 267.2 E(85289): 1.2e-71 Smith-Waterman score: 1211; 92.2% identity (97.9% similar) in 192 aa overlap (1-192:1-192) 10 20 30 40 50 60 pF1KB8 MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAG :::::::::::::::::::::::::::::::::::::::::::::::.:::::::::::: NP_002 MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDSKPVNLGLWDTAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 QEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVRHHCPNTPIILVGTKLDLR :::::::::::::::::::::::::::::.:::::::.::::::::.::::::::::::: NP_002 QEDYDRLRPLSYPQTDVFLICFSLVSPASYENVRAKWFPEVRHHCPSTPIILVGTKLDLR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 DDKDTIEKLKEKKLTPITYPQGLAMAKEIGAVKYLECSALTQRGLKTVFDEAIRAVLCPP ::::::::::::::.:::::::::.:::: .:::::::::::::::::::::::::::: NP_002 DDKDTIEKLKEKKLAPITYPQGLALAKEIDSVKYLECSALTQRGLKTVFDEAIRAVLCPQ 130 140 150 160 170 180 190 pF1KB8 PVKKRKRKCLLL :....:: : :: NP_002 PTRQQKRACSLL 190 >>NP_001303236 (OMIM: 602050) ras-related C3 botulinum t (170 aa) initn: 1030 init1: 994 opt: 994 Z-score: 1157.6 bits: 220.8 E(85289): 9.6e-58 Smith-Waterman score: 994; 94.1% identity (100.0% similar) in 152 aa overlap (1-152:1-152) 10 20 30 40 50 60 pF1KB8 MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 QEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVRHHCPNTPIILVGTKLDLR ::::::::::::::::::::::::::::::::::::::::::::::.:::.::::::::: NP_001 QEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVRHHCPHTPILLVGTKLDLR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 DDKDTIEKLKEKKLTPITYPQGLAMAKEIGAVKYLECSALTQRGLKTVFDEAIRAVLCPP :::::::.:..:::.:::::::::::.:::.. NP_001 DDKDTIERLRDKKLAPITYPQGLAMAREIGGLCEIPGVLSPDPAGPEDSV 130 140 150 160 170 190 pF1KB8 PVKKRKRKCLLL >>XP_006724349 (OMIM: 602049,608203) PREDICTED: ras-rela (161 aa) initn: 981 init1: 981 opt: 981 Z-score: 1142.9 bits: 218.0 E(85289): 6.4e-57 Smith-Waterman score: 981; 96.0% identity (100.0% similar) in 149 aa overlap (1-149:1-149) 10 20 30 40 50 60 pF1KB8 MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAG :::::::::::::::::::::::::::::::::::::::::::::::.:::::::::::: XP_006 MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDSKPVNLGLWDTAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 QEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVRHHCPNTPIILVGTKLDLR :::::::::::::::::::::::::::::.:::::::.::::::::.::::::::::::: XP_006 QEDYDRLRPLSYPQTDVFLICFSLVSPASYENVRAKWFPEVRHHCPSTPIILVGTKLDLR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 DDKDTIEKLKEKKLTPITYPQGLAMAKEIGAVKYLECSALTQRGLKTVFDEAIRAVLCPP ::::::::::::::.:::::::::.:::: XP_006 DDKDTIEKLKEKKLAPITYPQGLALAKEIEKHQNSRPPSTD 130 140 150 160 >>NP_001782 (OMIM: 116952,616737) cell division control (191 aa) initn: 938 init1: 938 opt: 945 Z-score: 1100.5 bits: 210.4 E(85289): 1.5e-54 Smith-Waterman score: 945; 70.8% identity (89.1% similar) in 192 aa overlap (1-192:1-191) 10 20 30 40 50 60 pF1KB8 MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAG ::.::::::::::::::::::::::: ::.::.:::::::...::. :.: .:::.:::: NP_001 MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 QEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVRHHCPNTPIILVGTKLDLR :::::::::::::::::::.:::.:::.:::::. :: ::. ::::.::..::::..::: NP_001 QEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVGTQIDLR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 DDKDTIEKLKEKKLTPITYPQGLAMAKEIGAVKYLECSALTQRGLKTVFDEAIRAVLCPP :: .::::: ..: ::: . .:... ::::.:::::::.:::.:::::: :.: :: NP_001 DDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQKGLKNVFDEAILAALEPP 130 140 150 160 170 180 190 pF1KB8 PVKKRKRKCLLL :: .:.:.:: NP_001 EPKK-SRRCVLL 190 >>NP_001034891 (OMIM: 116952,616737) cell division contr (191 aa) initn: 938 init1: 938 opt: 945 Z-score: 1100.5 bits: 210.4 E(85289): 1.5e-54 Smith-Waterman score: 945; 70.8% identity (89.1% similar) in 192 aa overlap (1-192:1-191) 10 20 30 40 50 60 pF1KB8 MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAG ::.::::::::::::::::::::::: ::.::.:::::::...::. :.: .:::.:::: NP_001 MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 QEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVRHHCPNTPIILVGTKLDLR :::::::::::::::::::.:::.:::.:::::. :: ::. ::::.::..::::..::: NP_001 QEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVGTQIDLR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 DDKDTIEKLKEKKLTPITYPQGLAMAKEIGAVKYLECSALTQRGLKTVFDEAIRAVLCPP :: .::::: ..: ::: . .:... ::::.:::::::.:::.:::::: :.: :: NP_001 DDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQKGLKNVFDEAILAALEPP 130 140 150 160 170 180 190 pF1KB8 PVKKRKRKCLLL :: .:.:.:: NP_001 EPKK-SRRCVLL 190 >>NP_426359 (OMIM: 116952,616737) cell division control (191 aa) initn: 1011 init1: 941 opt: 941 Z-score: 1095.9 bits: 209.5 E(85289): 2.6e-54 Smith-Waterman score: 941; 69.1% identity (89.0% similar) in 191 aa overlap (1-191:1-191) 10 20 30 40 50 60 pF1KB8 MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAG ::.::::::::::::::::::::::: ::.::.:::::::...::. :.: .:::.:::: NP_426 MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 QEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVRHHCPNTPIILVGTKLDLR :::::::::::::::::::.:::.:::.:::::. :: ::. ::::.::..::::..::: NP_426 QEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVGTQIDLR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 DDKDTIEKLKEKKLTPITYPQGLAMAKEIGAVKYLECSALTQRGLKTVFDEAIRAVLCPP :: .::::: ..: ::: . .:... ::::.:::::::::::.:::::: :.: :: NP_426 DDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQRGLKNVFDEAILAALEPP 130 140 150 160 170 180 190 pF1KB8 PVKKRKRKCLLL .. ... :.. NP_426 ETQPKRKCCIF 190 >>NP_001656 (OMIM: 179505) rho-related GTP-binding prote (191 aa) initn: 918 init1: 918 opt: 936 Z-score: 1090.2 bits: 208.5 E(85289): 5.5e-54 Smith-Waterman score: 936; 71.9% identity (86.5% similar) in 192 aa overlap (1-192:1-191) 10 20 30 40 50 60 pF1KB8 MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAG ::.:::::::::::::::::: ::::::: ::::::::::::. :::. :::.:::::: NP_001 MQSIKCVVVGDGAVGKTCLLICYTTNAFPKEYIPTVFDNYSAQSAVDGRTVNLNLWDTAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 QEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVRHHCPNTPIILVGTKLDLR ::.::::: ::::::.::.::::..:: :.:::: ::.::: ::::..::.::::: ::: NP_001 QEEYDRLRTLSYPQTNVFVICFSIASPPSYENVRHKWHPEVCHHCPDVPILLVGTKKDLR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 DDKDTIEKLKEKKLTPITYPQGLAMAKEIGAVKYLECSALTQRGLKTVFDEAIRAVLCPP . ::...:::. .::: :: :.::.: ::.::::::: : :.: :: ::.:::: : NP_001 AQPDTLRRLKEQGQAPITPQQGQALAKQIHAVRYLECSALQQDGVKEVFAEAVRAVLNPT 130 140 150 160 170 180 190 pF1KB8 PVKKRKRKCLLL :.: : :.:.:: NP_001 PIK-RGRSCILL 190 >>XP_005252973 (OMIM: 179505) PREDICTED: rho-related GTP (191 aa) initn: 918 init1: 918 opt: 936 Z-score: 1090.2 bits: 208.5 E(85289): 5.5e-54 Smith-Waterman score: 936; 71.9% identity (86.5% similar) in 192 aa overlap (1-192:1-191) 10 20 30 40 50 60 pF1KB8 MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAG ::.:::::::::::::::::: ::::::: ::::::::::::. :::. :::.:::::: XP_005 MQSIKCVVVGDGAVGKTCLLICYTTNAFPKEYIPTVFDNYSAQSAVDGRTVNLNLWDTAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 QEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVRHHCPNTPIILVGTKLDLR ::.::::: ::::::.::.::::..:: :.:::: ::.::: ::::..::.::::: ::: XP_005 QEEYDRLRTLSYPQTNVFVICFSIASPPSYENVRHKWHPEVCHHCPDVPILLVGTKKDLR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 DDKDTIEKLKEKKLTPITYPQGLAMAKEIGAVKYLECSALTQRGLKTVFDEAIRAVLCPP . ::...:::. .::: :: :.::.: ::.::::::: : :.: :: ::.:::: : XP_005 AQPDTLRRLKEQGQAPITPQQGQALAKQIHAVRYLECSALQQDGVKEVFAEAVRAVLNPT 130 140 150 160 170 180 190 pF1KB8 PVKKRKRKCLLL :.: : :.:.:: XP_005 PIK-RGRSCILL 190 192 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 11:03:38 2016 done: Fri Nov 4 11:03:39 2016 Total Scan time: 4.600 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]