FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8261, 155 aa 1>>>pF1KB8261 155 - 155 aa - 155 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.0362+/-0.000417; mu= 13.6266+/- 0.026 mean_var=61.1193+/-12.936, 0's: 0 Z-trim(109.9): 29 B-trim: 0 in 0/54 Lambda= 0.164053 statistics sampled from 18103 (18126) to 18103 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.561), E-opt: 0.2 (0.213), width: 16 Scan time: 4.880 The best scores are: opt bits E(85289) NP_001685 (OMIM: 108745) V-type proton ATPase 16 k ( 155) 943 231.6 4e-61 NP_001185498 (OMIM: 108745) V-type proton ATPase 1 ( 155) 943 231.6 4e-61 NP_004038 (OMIM: 603717) V-type proton ATPase 21 k ( 205) 207 57.4 1.4e-08 NP_001034546 (OMIM: 603717) V-type proton ATPase 2 ( 158) 204 56.7 1.8e-08 NP_001281262 (OMIM: 603717) V-type proton ATPase 2 ( 261) 202 56.3 3.8e-08 NP_001002258 (OMIM: 602736) ATP synthase F(0) comp ( 142) 123 37.5 0.0098 NP_001680 (OMIM: 602736) ATP synthase F(0) complex ( 142) 123 37.5 0.0098 >>NP_001685 (OMIM: 108745) V-type proton ATPase 16 kDa p (155 aa) initn: 943 init1: 943 opt: 943 Z-score: 1218.4 bits: 231.6 E(85289): 4e-61 Smith-Waterman score: 943; 100.0% identity (100.0% similar) in 155 aa overlap (1-155:1-155) 10 20 30 40 50 60 pF1KB8 MSESKSGPEYASFFAVMGASAAMVFSALGAAYGTAKSGTGIAAMSVMRPEQIMKSIIPVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSESKSGPEYASFFAVMGASAAMVFSALGAAYGTAKSGTGIAAMSVMRPEQIMKSIIPVV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 MAGIIAIYGLVVAVLIANSLNDDISLYKSFLQLGAGLSVGLSGLAAGFAIGIVGDAGVRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAGIIAIYGLVVAVLIANSLNDDISLYKSFLQLGAGLSVGLSGLAAGFAIGIVGDAGVRG 70 80 90 100 110 120 130 140 150 pF1KB8 TAQQPRLFVGMILILIFAEVLGLYGLIVALILSTK ::::::::::::::::::::::::::::::::::: NP_001 TAQQPRLFVGMILILIFAEVLGLYGLIVALILSTK 130 140 150 >>NP_001185498 (OMIM: 108745) V-type proton ATPase 16 kD (155 aa) initn: 943 init1: 943 opt: 943 Z-score: 1218.4 bits: 231.6 E(85289): 4e-61 Smith-Waterman score: 943; 100.0% identity (100.0% similar) in 155 aa overlap (1-155:1-155) 10 20 30 40 50 60 pF1KB8 MSESKSGPEYASFFAVMGASAAMVFSALGAAYGTAKSGTGIAAMSVMRPEQIMKSIIPVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSESKSGPEYASFFAVMGASAAMVFSALGAAYGTAKSGTGIAAMSVMRPEQIMKSIIPVV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 MAGIIAIYGLVVAVLIANSLNDDISLYKSFLQLGAGLSVGLSGLAAGFAIGIVGDAGVRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAGIIAIYGLVVAVLIANSLNDDISLYKSFLQLGAGLSVGLSGLAAGFAIGIVGDAGVRG 70 80 90 100 110 120 130 140 150 pF1KB8 TAQQPRLFVGMILILIFAEVLGLYGLIVALILSTK ::::::::::::::::::::::::::::::::::: NP_001 TAQQPRLFVGMILILIFAEVLGLYGLIVALILSTK 130 140 150 >>NP_004038 (OMIM: 603717) V-type proton ATPase 21 kDa p (205 aa) initn: 332 init1: 192 opt: 207 Z-score: 275.1 bits: 57.4 E(85289): 1.4e-08 Smith-Waterman score: 299; 32.9% identity (71.1% similar) in 149 aa overlap (17-155:52-200) 10 20 30 40 pF1KB8 MSESKSGPEYASFFAVMGASAAMVFSALGAAYGTAKSGTGIAAMSV .: . :. .:..:::.: .:..: . .: NP_004 VGVCYTIFDLGFRFDVAWFLTETSPFMWSNLGIGLAISLSVVGAAWGIYITGSSIIGGGV 30 40 50 60 70 80 50 60 70 80 90 pF1KB8 MRPEQIMKSIIPVVMAGIIAIYGLVVAVLIAN-----SLNDDISL-----YKSFLQLGAG :. :... ... .::::...:..:.: : .: .. . .. ..::: NP_004 KAPRIKTKNLVSIIFCEAVAIYGIIMAIVISNMAEPFSATDPKAIGHRNYHAGYSMFGAG 90 100 110 120 130 140 100 110 120 130 140 150 pF1KB8 LSVGLSGLAAGFAIGIVGDAGVRGTAQQPRLFVGMILILIFAEVLGLYGLIVALILSTK :.::::.: : .::::.... . ::.: ::: .... ::. ..::.:.:::.. ... NP_004 LTVGLSNLFCGVCVGIVGSGAALADAQNPSLFVKILIVEIFGSAIGLFGVIVAILQTSRV 150 160 170 180 190 200 NP_004 KMGD >>NP_001034546 (OMIM: 603717) V-type proton ATPase 21 kD (158 aa) initn: 332 init1: 192 opt: 204 Z-score: 273.0 bits: 56.7 E(85289): 1.8e-08 Smith-Waterman score: 299; 32.9% identity (71.1% similar) in 149 aa overlap (17-155:5-153) 10 20 30 40 50 60 pF1KB8 MSESKSGPEYASFFAVMGASAAMVFSALGAAYGTAKSGTGIAAMSVMRPEQIMKSIIPVV .: . :. .:..:::.: .:..: . .: :. :... .. NP_001 MWSNLGIGLAISLSVVGAAWGIYITGSSIIGGGVKAPRIKTKNLVSII 10 20 30 40 70 80 90 100 110 pF1KB8 MAGIIAIYGLVVAVLIAN-----SLNDDISL-----YKSFLQLGAGLSVGLSGLAAGFAI . .::::...:..:.: : .: .. . .. ..::::.::::.: : . NP_001 FCEAVAIYGIIMAIVISNMAEPFSATDPKAIGHRNYHAGYSMFGAGLTVGLSNLFCGVCV 50 60 70 80 90 100 120 130 140 150 pF1KB8 GIVGDAGVRGTAQQPRLFVGMILILIFAEVLGLYGLIVALILSTK ::::.... . ::.: ::: .... ::. ..::.:.:::.. ... NP_001 GIVGSGAALADAQNPSLFVKILIVEIFGSAIGLFGVIVAILQTSRVKMGD 110 120 130 140 150 >>NP_001281262 (OMIM: 603717) V-type proton ATPase 21 kD (261 aa) initn: 327 init1: 187 opt: 202 Z-score: 267.2 bits: 56.3 E(85289): 3.8e-08 Smith-Waterman score: 294; 33.8% identity (71.0% similar) in 145 aa overlap (17-151:52-196) 10 20 30 40 pF1KB8 MSESKSGPEYASFFAVMGASAAMVFSALGAAYGTAKSGTGIAAMSV .: . :. .:..:::.: .:..: . .: NP_001 VGVCYTIFDLGFRFDVAWFLTETSPFMWSNLGIGLAISLSVVGAAWGIYITGSSIIGGGV 30 40 50 60 70 80 50 60 70 80 90 pF1KB8 MRPEQIMKSIIPVVMAGIIAIYGLVVAVLIAN-----SLNDDISL-----YKSFLQLGAG :. :... ... .::::...:..:.: : .: .. . .. ..::: NP_001 KAPRIKTKNLVSIIFCEAVAIYGIIMAIVISNMAEPFSATDPKAIGHRNYHAGYSMFGAG 90 100 110 120 130 140 100 110 120 130 140 150 pF1KB8 LSVGLSGLAAGFAIGIVGDAGVRGTAQQPRLFVGMILILIFAEVLGLYGLIVALILSTK :.::::.: : .::::.... . ::.: ::: .... ::. ..::.:.:::.. NP_001 LTVGLSNLFCGVCVGIVGSGAALADAQNPSLFVKILIVEIFGSAIGLFGVIVAILQVMNP 150 160 170 180 190 200 NP_001 LGKPLCPCPQPSLTLLLEKLKCSPSLPITIDSPKQLPPPHFHLLVFSYRGSLFLSLIWCH 210 220 230 240 250 260 >>NP_001002258 (OMIM: 602736) ATP synthase F(0) complex (142 aa) initn: 116 init1: 78 opt: 123 Z-score: 170.1 bits: 37.5 E(85289): 0.0098 Smith-Waterman score: 123; 27.0% identity (56.7% similar) in 141 aa overlap (17-152:1-138) 10 20 30 40 50 60 pF1KB8 MSESKSGPEYASFFAVMGASAAMVFSALGAAYGTAKSGTGIAAMSVMRPEQIMKSIIPVV : : : .. . :. . :.: . ::: . .: NP_001 MFACAKLACTPSLIRAGSRVAYRPISASVLSRPEASRTGEGSTV 10 20 30 40 70 80 90 100 110 pF1KB8 MAGII-AIYGLVVAVLIANSLNDDISLYKSFLQLGAGLSVGLSGLAAGFAIGIVGDAGVR . : .. :. . ..... ::. .:. ::. .::..: .:: :: : . . NP_001 FNGAQNGVSQLIQREFQTSAISRDIDTAAKFIGAGAA-TVGVAGSGAG--IGTVFGSLII 50 60 70 80 90 100 120 130 140 150 pF1KB8 GTAQQP----RLFVGMILILIFAEVLGLYGLIVALILSTK : :..: .:: :: . ..:..::. :.::... NP_001 GYARNPSLKQQLFSYAILGFALSEAMGLFCLMVAFLILFAM 110 120 130 140 >>NP_001680 (OMIM: 602736) ATP synthase F(0) complex sub (142 aa) initn: 116 init1: 78 opt: 123 Z-score: 170.1 bits: 37.5 E(85289): 0.0098 Smith-Waterman score: 123; 27.0% identity (56.7% similar) in 141 aa overlap (17-152:1-138) 10 20 30 40 50 60 pF1KB8 MSESKSGPEYASFFAVMGASAAMVFSALGAAYGTAKSGTGIAAMSVMRPEQIMKSIIPVV : : : .. . :. . :.: . ::: . .: NP_001 MFACAKLACTPSLIRAGSRVAYRPISASVLSRPEASRTGEGSTV 10 20 30 40 70 80 90 100 110 pF1KB8 MAGII-AIYGLVVAVLIANSLNDDISLYKSFLQLGAGLSVGLSGLAAGFAIGIVGDAGVR . : .. :. . ..... ::. .:. ::. .::..: .:: :: : . . NP_001 FNGAQNGVSQLIQREFQTSAISRDIDTAAKFIGAGAA-TVGVAGSGAG--IGTVFGSLII 50 60 70 80 90 100 120 130 140 150 pF1KB8 GTAQQP----RLFVGMILILIFAEVLGLYGLIVALILSTK : :..: .:: :: . ..:..::. :.::... NP_001 GYARNPSLKQQLFSYAILGFALSEAMGLFCLMVAFLILFAM 110 120 130 140 155 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 11:07:13 2016 done: Fri Nov 4 11:07:14 2016 Total Scan time: 4.880 Total Display time: -0.020 Function used was FASTA [36.3.4 Apr, 2011]