Result of FASTA (omim) for
pF1KB8269
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB8269, 201 aa
1>>>pF1KB8269 201 - 201 aa - 201 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.1117+/-0.00038; mu= 13.9067+/- 0.024
mean_var=57.1707+/-11.391, 0's: 0 Z-trim(111.5): 38 B-trim: 0 in 0/52
Lambda= 0.169624
statistics sampled from 20114 (20150) to 20114 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.614), E-opt: 0.2 (0.236), width: 16
Scan time: 4.710
The best scores are: opt bits E(85289)
NP_002785 (OMIM: 602175) proteasome subunit beta t ( 201) 1319 331.0 8.1e-91
NP_001186708 (OMIM: 602175) proteasome subunit bet ( 176) 1129 284.4 7.2e-77
NP_001186709 (OMIM: 602175) proteasome subunit bet ( 84) 545 141.4 4e-34
NP_002784 (OMIM: 602017) proteasome subunit beta t ( 241) 223 62.8 5.2e-10
NP_002787 (OMIM: 602177) proteasome subunit beta t ( 264) 186 53.7 3e-07
NP_004150 (OMIM: 177046,256040) proteasome subunit ( 272) 173 50.6 2.8e-06
NP_683720 (OMIM: 177046,256040) proteasome subunit ( 276) 173 50.6 2.8e-06
NP_002788 (OMIM: 600306) proteasome subunit beta t ( 263) 162 47.9 1.7e-05
NP_002792 (OMIM: 176847) proteasome subunit beta t ( 273) 162 47.9 1.8e-05
NP_002791 (OMIM: 177045) proteasome subunit beta t ( 219) 159 47.1 2.5e-05
NP_002786 (OMIM: 602176) proteasome subunit beta t ( 205) 154 45.9 5.5e-05
NP_002789 (OMIM: 600307) proteasome subunit beta t ( 239) 151 45.2 0.0001
NP_001257410 (OMIM: 600307) proteasome subunit bet ( 213) 148 44.4 0.00016
NP_001124197 (OMIM: 600306) proteasome subunit bet ( 160) 138 41.9 0.00067
>>NP_002785 (OMIM: 602175) proteasome subunit beta type- (201 aa)
initn: 1319 init1: 1319 opt: 1319 Z-score: 1751.5 bits: 331.0 E(85289): 8.1e-91
Smith-Waterman score: 1319; 100.0% identity (100.0% similar) in 201 aa overlap (1-201:1-201)
10 20 30 40 50 60
pF1KB8 MEYLIGIQGPDYVLVASDRVAASNIVQMKDDHDKMFKMSEKILLLCVGEAGDTVQFAEYI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MEYLIGIQGPDYVLVASDRVAASNIVQMKDDHDKMFKMSEKILLLCVGEAGDTVQFAEYI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 QKNVQLYKMRNGYELSPTAAANFTRRNLADCLRSRTPYHVNLLLAGYDEHEGPALYYMDY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 QKNVQLYKMRNGYELSPTAAANFTRRNLADCLRSRTPYHVNLLLAGYDEHEGPALYYMDY
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 LAALAKAPFAAHGYGAFLTLSILDRYYTPTISRERAVELLRKCLEELQKRFILNLPTFSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 LAALAKAPFAAHGYGAFLTLSILDRYYTPTISRERAVELLRKCLEELQKRFILNLPTFSV
130 140 150 160 170 180
190 200
pF1KB8 RIIDKNGIHDLDNISFPKQGS
:::::::::::::::::::::
NP_002 RIIDKNGIHDLDNISFPKQGS
190 200
>>NP_001186708 (OMIM: 602175) proteasome subunit beta ty (176 aa)
initn: 1146 init1: 1129 opt: 1129 Z-score: 1501.1 bits: 284.4 E(85289): 7.2e-77
Smith-Waterman score: 1129; 100.0% identity (100.0% similar) in 171 aa overlap (31-201:6-176)
10 20 30 40 50 60
pF1KB8 MEYLIGIQGPDYVLVASDRVAASNIVQMKDDHDKMFKMSEKILLLCVGEAGDTVQFAEYI
::::::::::::::::::::::::::::::
NP_001 MEYLIDHDKMFKMSEKILLLCVGEAGDTVQFAEYI
10 20 30
70 80 90 100 110 120
pF1KB8 QKNVQLYKMRNGYELSPTAAANFTRRNLADCLRSRTPYHVNLLLAGYDEHEGPALYYMDY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QKNVQLYKMRNGYELSPTAAANFTRRNLADCLRSRTPYHVNLLLAGYDEHEGPALYYMDY
40 50 60 70 80 90
130 140 150 160 170 180
pF1KB8 LAALAKAPFAAHGYGAFLTLSILDRYYTPTISRERAVELLRKCLEELQKRFILNLPTFSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LAALAKAPFAAHGYGAFLTLSILDRYYTPTISRERAVELLRKCLEELQKRFILNLPTFSV
100 110 120 130 140 150
190 200
pF1KB8 RIIDKNGIHDLDNISFPKQGS
:::::::::::::::::::::
NP_001 RIIDKNGIHDLDNISFPKQGS
160 170
>>NP_001186709 (OMIM: 602175) proteasome subunit beta ty (84 aa)
initn: 545 init1: 545 opt: 545 Z-score: 733.7 bits: 141.4 E(85289): 4e-34
Smith-Waterman score: 545; 100.0% identity (100.0% similar) in 84 aa overlap (118-201:1-84)
90 100 110 120 130 140
pF1KB8 LADCLRSRTPYHVNLLLAGYDEHEGPALYYMDYLAALAKAPFAAHGYGAFLTLSILDRYY
::::::::::::::::::::::::::::::
NP_001 MDYLAALAKAPFAAHGYGAFLTLSILDRYY
10 20 30
150 160 170 180 190 200
pF1KB8 TPTISRERAVELLRKCLEELQKRFILNLPTFSVRIIDKNGIHDLDNISFPKQGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TPTISRERAVELLRKCLEELQKRFILNLPTFSVRIIDKNGIHDLDNISFPKQGS
40 50 60 70 80
>>NP_002784 (OMIM: 602017) proteasome subunit beta type- (241 aa)
initn: 175 init1: 107 opt: 223 Z-score: 300.7 bits: 62.8 E(85289): 5.2e-10
Smith-Waterman score: 223; 24.6% identity (56.5% similar) in 207 aa overlap (4-198:40-240)
10 20 30
pF1KB8 MEYLIGIQGPDYVLVASDRVAASNIVQMKDDHD
...: : :...:::: . .. :
NP_002 APGRDLGMEPHRAAGPLQLRFSPYVFNGGTILAIAGEDFAIVASDTRLSEGFSIHTRDSP
10 20 30 40 50 60
40 50 60 70 80 90
pF1KB8 KMFKMSEKILLLCVGEAGDTVQFAEYIQKNVQLYKMRNGYELSPTAAANFTRRNLADCLR
: .:...: .. : : :: . ... :. ...:: :. .. : : . :. :
NP_002 KCYKLTDKTVIGCSGFHGDCLTLTKIIEARLKMYKHSNNKAMTTGAIAAM----LSTILY
70 80 90 100 110 120
100 110 120 130 140
pF1KB8 SRT--PYHVNLLLAGYDEHEGPALYYMDYLAALAKAPFAAHGYGAFLTLSILDRY-----
:: ::.: ...: ::. :.: .: ... . : : : .. . .::
NP_002 SRRFFPYYVYNIIGGLDEEGKGAVYSFDPVGSYQRDSFKAGGSASAMLQPLLDNQVGFKN
130 140 150 160 170 180
150 160 170 180 190 200
pF1KB8 -----YTPTISRERAVELLRKCLEELQKRFILNLPTFSVRIIDKNGIHDLDNISFPKQGS
..: .: .::..:.. . .: . . .. . :. :.::.. ...:. :
NP_002 MQNVEHVP-LSLDRAMRLVKDVFISAAERDVYTGDALRICIVTKEGIRE-ETVSLRKD
190 200 210 220 230 240
>>NP_002787 (OMIM: 602177) proteasome subunit beta type- (264 aa)
initn: 89 init1: 55 opt: 186 Z-score: 251.2 bits: 53.7 E(85289): 3e-07
Smith-Waterman score: 186; 21.2% identity (59.3% similar) in 189 aa overlap (4-188:56-242)
10 20 30
pF1KB8 MEYLIGIQGPDYVLVASDRVAASNIVQMKDDHD
..:.. :..:.: ... . . . .
NP_002 STPDSFMDPASALYRGPITRTQNPMVTGTSVLGVKFEGGVVIAADMLGSYGSLARFRNIS
30 40 50 60 70 80
40 50 60 70 80 90
pF1KB8 KMFKMSEKILLLCVGEAGDTVQFAEYI--QKNVQLYKMRNGYELSPTAAANFTRRNLADC
........ .: :. .: :. . . : .. . .:. :: : .. : . .
NP_002 RIMRVNNSTMLGASGDYAD-FQYLKQVLGQMVIDEELLGDGHSYSPRAIHSWLTRAMYSR
90 100 110 120 130 140
100 110 120 130 140
pF1KB8 LRSRTPYHVNLLLAGYDEHEGPALYYMDYLAALAKAPFAAHGYGAFLTLSILDRYYT--P
. .: .....:: . :. : :.:.:.. .:: : ::::.:. .: . :
NP_002 RSKMNPLWNTMVIGGYADGES-FLGYVDMLGVAYEAPSLATGYGAYLAQPLLREVLEKQP
150 160 170 180 190 200
150 160 170 180 190 200
pF1KB8 TISRERAVELLRKCLEELQKRFILNLPTFSVRIIDKNGIHDLDNISFPKQGS
..:. .: .:...:.. : : . :.. . ..:.
NP_002 VLSQTEARDLVERCMRVLYYRDARSYNRFQIATVTEKGVEIEGPLSTETNWDIAHMISGF
210 220 230 240 250 260
NP_002 E
>>NP_004150 (OMIM: 177046,256040) proteasome subunit bet (272 aa)
initn: 86 init1: 52 opt: 173 Z-score: 233.8 bits: 50.6 E(85289): 2.8e-06
Smith-Waterman score: 173; 24.5% identity (59.1% similar) in 159 aa overlap (13-170:80-234)
10 20 30 40
pF1KB8 MEYLIGIQGPDYVLVASD-RVAASNIVQMKDDHDKMFKMSEK
:..: : :..:.. .. .:.....
NP_004 FQSLGGDGERNVQIEMAHGTTTLAFKFQHGVIAAVDSRASAGSYISALRV-NKVIEINPY
50 60 70 80 90 100
50 60 70 80 90 100
pF1KB8 ILLLCVGEAGDTVQFAEYIQKNVQLYKMRNGYELSPTAAANFTRRNLADCLRSRTPYHVN
.: : :.: . . . :. .:: .::: ..: .::... . : ..
NP_004 LLGTMSGCAADCQYWERLLAKECRLYYLRNGERISVSAASKLLSNMM--CQYRGMGLSMG
110 120 130 140 150 160
110 120 130 140 150 160
pF1KB8 LLLAGYDEHEGPALYYMDYLAALAKAPFAAHGYGAFLTLSILDRYYTPTISRERAVELLR
.. :.:. .::.:::.: .. .. . . : : . ...: : :..: :.: .: :
NP_004 SMICGWDK-KGPGLYYVDEHGTRLSGNMFSTGSGNTYAYGVMDSGYRPNLSPEEAYDLGR
170 180 190 200 210 220
170 180 190 200
pF1KB8 KCLEELQKRFILNLPTFSVRIIDKNGIHDLDNISFPKQGS
. . .:
NP_004 RAIAYATHRDSYSGGVVNMYHMKEDGWVKVESTDVSDLLHQYREANQ
230 240 250 260 270
>>NP_683720 (OMIM: 177046,256040) proteasome subunit bet (276 aa)
initn: 86 init1: 52 opt: 173 Z-score: 233.7 bits: 50.6 E(85289): 2.8e-06
Smith-Waterman score: 173; 24.5% identity (59.1% similar) in 159 aa overlap (13-170:84-238)
10 20 30 40
pF1KB8 MEYLIGIQGPDYVLVASD-RVAASNIVQMKDDHDKMFKMSEK
:..: : :..:.. .. .:.....
NP_683 FQSLGGDGERNVQIEMAHGTTTLAFKFQHGVIAAVDSRASAGSYISALRV-NKVIEINPY
60 70 80 90 100 110
50 60 70 80 90 100
pF1KB8 ILLLCVGEAGDTVQFAEYIQKNVQLYKMRNGYELSPTAAANFTRRNLADCLRSRTPYHVN
.: : :.: . . . :. .:: .::: ..: .::... . : ..
NP_683 LLGTMSGCAADCQYWERLLAKECRLYYLRNGERISVSAASKLLSNMM--CQYRGMGLSMG
120 130 140 150 160 170
110 120 130 140 150 160
pF1KB8 LLLAGYDEHEGPALYYMDYLAALAKAPFAAHGYGAFLTLSILDRYYTPTISRERAVELLR
.. :.:. .::.:::.: .. .. . . : : . ...: : :..: :.: .: :
NP_683 SMICGWDK-KGPGLYYVDEHGTRLSGNMFSTGSGNTYAYGVMDSGYRPNLSPEEAYDLGR
180 190 200 210 220
170 180 190 200
pF1KB8 KCLEELQKRFILNLPTFSVRIIDKNGIHDLDNISFPKQGS
. . .:
NP_683 RAIAYATHRDSYSGGVVNMYHMKEDGWVKVESTDVSDLLHQYREANQ
230 240 250 260 270
>>NP_002788 (OMIM: 600306) proteasome subunit beta type- (263 aa)
initn: 70 init1: 70 opt: 162 Z-score: 219.4 bits: 47.9 E(85289): 1.7e-05
Smith-Waterman score: 162; 23.6% identity (61.5% similar) in 161 aa overlap (13-170:71-225)
10 20 30 40
pF1KB8 MEYLIGIQGPDYVLVASDRVAASNIVQMKDDHDKMFKMSEKI
:.::.: :... .. :..... .
NP_002 LAAPGWGVPEEPGIEMLHGTTTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYL
50 60 70 80 90 100
50 60 70 80 90 100
pF1KB8 LLLCVGEAGDTVQFAEYIQKNVQLYKMRNGYELSPTAAANFTRRNLADCLRSRTPYHVNL
: .: :.: . . . .. ..:..:: ..: .::... ::. . . . ...
NP_002 LGTMAGGAADCSFWERLLARQCRIYELRNKERISVAAASKL----LANMVYQYKGMGLSM
110 120 130 140 150
110 120 130 140 150
pF1KB8 --LLAGYDEHEGPALYYMDYLAA-LAKAPFAAHGYGAFLTLSILDRYYTPTISRERAVEL
.. :.:.. ::.:::.: . .. : :.. : :. . ...:: :. . :.: .:
NP_002 GTMICGWDKR-GPGLYYVDSEGNRISGATFSV-GSGSVYAYGVMDRGYSYDLEVEQAYDL
160 170 180 190 200 210
160 170 180 190 200
pF1KB8 LRKCLEELQKRFILNLPTFSVRIIDKNGIHDLDNISFPKQGS
:. . . :
NP_002 ARRAIYQATYRDAYSGGAVNLYHVREDGWIRVSSDNVADLHEKYSGSTP
220 230 240 250 260
>>NP_002792 (OMIM: 176847) proteasome subunit beta type- (273 aa)
initn: 90 init1: 90 opt: 162 Z-score: 219.2 bits: 47.9 E(85289): 1.8e-05
Smith-Waterman score: 162; 22.6% identity (58.3% similar) in 199 aa overlap (4-199:42-233)
10 20 30
pF1KB8 MEYLIGIQGPDYVLVASDRVAASNIVQMKDDHD
. :. : :....: :... : . .
NP_002 FSFENCQRNASLERVLPGLKVPHARKTGTTIAGLVFQDGVILGADTRATNDSVVADKSCE
20 30 40 50 60 70
40 50 60 70 80 90
pF1KB8 KMFKMSEKILLLCVGEAGDTVQFAEYIQKNVQLYKMRNGYELSPTAAANFTRRNLADCLR
:. .. :: .: :.:. . .... ....:. . .: : .... . :..: .:
NP_002 KIHFIAPKIYCCGAGVAADAEMTTRMVASKMELHALSTGREPRVATVTRILRQTL---FR
80 90 100 110 120
100 110 120 130 140 150
pF1KB8 SRTPYHVNLLLAGYDEHEGPALYYMDYLAALAKAPFAAHGYGAFLTLSILDRYYTPTISR
. ..:...: : :: :: . .. .. ::.: : : .:..:. . :...
NP_002 YQGHVGASLIVGGVDL-TGPQLYGVHPHGSYSRLPFTALGSGQDAALAVLEDRFQPNMTL
130 140 150 160 170 180
160 170 180 190 200
pF1KB8 ERAVELLRKCLEELQKRFILNLPT---FSVRIIDKNGIHDLDNISFPKQGS
: : :: .: . .. .: . .. .: :.: . : ..: : .
NP_002 EAAQGLL---VEAVTAGILGDLGSGGNVDACVITKTGAKLLRTLSSPTEPVKRSGRYHFV
190 200 210 220 230 240
NP_002 PGTTAVLTQTVKPLTLELVEETVQAMEVE
250 260 270
>>NP_002791 (OMIM: 177045) proteasome subunit beta type- (219 aa)
initn: 92 init1: 61 opt: 159 Z-score: 216.7 bits: 47.1 E(85289): 2.5e-05
Smith-Waterman score: 159; 27.9% identity (57.8% similar) in 154 aa overlap (4-154:23-169)
10 20 30 40
pF1KB8 MEYLIGIQGPDYVLVASD-RVAASNIVQMKDDHDKMFKMSE
..... :...:: ::.:.. : .. ::. . :
NP_002 MLRAGAPTGDLPRAGEVHTGTTIMAVEFDGGVVMGSDSRVSAGEAV-VNRVFDKLSPLHE
10 20 30 40 50
50 60 70 80 90
pF1KB8 KILLLCVGEAGDTVQFAEYIQKNVQLYKMRNGYELSPT--AAANFTRRNLADCLRSRTPY
.: : :.:. :.. ...:. .. : : :::: .: :.. . :
NP_002 RIYCALSGSAADAQAVADMAAYQLELHGIE--LEEPPLVLAAANVVR-NIS--YKYREDL
60 70 80 90 100 110
100 110 120 130 140 150
pF1KB8 HVNLLLAGYDEHEGPALYYMDYLAALAKAPFAAHGYGAFLTLSILDRYYTPTISRERAVE
..:..::.:..:: .: . :.. ::: : :. . . .: : : .: :
NP_002 SAHLMVAGWDQREGGQVYGT-LGGMLTRQPFAIGGSGSTFIYGYVDAAYKPGMSPEECRR
120 130 140 150 160 170
160 170 180 190 200
pF1KB8 LLRKCLEELQKRFILNLPTFSVRIIDKNGIHDLDNISFPKQGS
NP_002 FTTDAIALAMSRDGSSGGVIYLVTITAAGVDHRVILGNELPKFYDE
180 190 200 210
201 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 11:14:17 2016 done: Fri Nov 4 11:14:18 2016
Total Scan time: 4.710 Total Display time: 0.000
Function used was FASTA [36.3.4 Apr, 2011]