FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8275, 306 aa 1>>>pF1KB8275 306 - 306 aa - 306 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.6529+/-0.000443; mu= 13.6149+/- 0.028 mean_var=279.4367+/-62.180, 0's: 0 Z-trim(118.8): 164 B-trim: 1880 in 1/55 Lambda= 0.076724 statistics sampled from 31864 (32098) to 31864 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.72), E-opt: 0.2 (0.376), width: 16 Scan time: 7.260 The best scores are: opt bits E(85289) NP_002129 (OMIM: 601324) heterogeneous nuclear rib ( 306) 2042 239.1 8.6e-63 NP_112738 (OMIM: 601324) heterogeneous nuclear rib ( 355) 1887 222.0 1.4e-57 NP_001003810 (OMIM: 601324) heterogeneous nuclear ( 287) 1487 177.6 2.6e-44 NP_112737 (OMIM: 601324) heterogeneous nuclear rib ( 336) 1332 160.5 4.1e-39 NP_001193929 (OMIM: 607137,609115) heterogeneous n ( 363) 1071 131.7 2.1e-30 NP_004490 (OMIM: 602688) heterogeneous nuclear rib ( 285) 1065 130.9 3e-30 NP_112556 (OMIM: 602688) heterogeneous nuclear rib ( 332) 988 122.5 1.2e-27 NP_112740 (OMIM: 607137,609115) heterogeneous nucl ( 420) 988 122.6 1.3e-27 NP_001317180 (OMIM: 605372) heterogeneous nuclear ( 331) 606 80.2 6.4e-15 NP_001317179 (OMIM: 605372) heterogeneous nuclear ( 331) 606 80.2 6.4e-15 NP_919223 (OMIM: 605372) heterogeneous nuclear rib ( 378) 606 80.3 6.8e-15 NP_001317178 (OMIM: 605372) heterogeneous nuclear ( 378) 606 80.3 6.8e-15 NP_001317177 (OMIM: 605372) heterogeneous nuclear ( 356) 600 79.6 1e-14 NP_001317176 (OMIM: 605372) heterogeneous nuclear ( 356) 600 79.6 1e-14 NP_002128 (OMIM: 600124,615422) heterogeneous nucl ( 341) 576 76.9 6.4e-14 XP_016867598 (OMIM: 600124,615422) PREDICTED: hete ( 341) 576 76.9 6.4e-14 XP_016867599 (OMIM: 600124,615422) PREDICTED: hete ( 341) 576 76.9 6.4e-14 NP_112533 (OMIM: 600124,615422) heterogeneous nucl ( 353) 576 76.9 6.6e-14 XP_005249786 (OMIM: 600124,615422) PREDICTED: hete ( 353) 576 76.9 6.6e-14 XP_016874740 (OMIM: 164017,615424,615426) PREDICTE ( 295) 557 74.7 2.6e-13 NP_002127 (OMIM: 164017,615424,615426) heterogeneo ( 320) 557 74.7 2.7e-13 XP_005268883 (OMIM: 164017,615424,615426) PREDICTE ( 372) 557 74.8 2.9e-13 NP_112420 (OMIM: 164017,615424,615426) heterogeneo ( 372) 557 74.8 2.9e-13 NP_001309180 (OMIM: 607897) RNA-binding protein Mu ( 255) 552 74.0 3.5e-13 XP_016879637 (OMIM: 607897) PREDICTED: RNA-binding ( 295) 552 74.1 3.8e-13 NP_620412 (OMIM: 607897) RNA-binding protein Musas ( 328) 552 74.2 4e-13 XP_005257072 (OMIM: 607897) PREDICTED: RNA-binding ( 346) 552 74.2 4.1e-13 XP_005257071 (OMIM: 607897) PREDICTED: RNA-binding ( 346) 552 74.2 4.1e-13 NP_733839 (OMIM: 607897) RNA-binding protein Musas ( 251) 542 72.9 7.5e-13 NP_001309179 (OMIM: 607897) RNA-binding protein Mu ( 324) 536 72.4 1.4e-12 XP_011536665 (OMIM: 603328) PREDICTED: RNA-binding ( 332) 523 71.0 3.7e-12 XP_011536664 (OMIM: 603328) PREDICTED: RNA-binding ( 343) 523 71.0 3.8e-12 XP_006719466 (OMIM: 603328) PREDICTED: RNA-binding ( 351) 523 71.0 3.8e-12 NP_002433 (OMIM: 603328) RNA-binding protein Musas ( 362) 523 71.0 3.9e-12 XP_011536663 (OMIM: 603328) PREDICTED: RNA-binding ( 362) 523 71.0 3.9e-12 NP_006796 (OMIM: 609409) heterogeneous nuclear rib ( 305) 471 65.2 1.9e-10 XP_016856353 (OMIM: 605078,612069) PREDICTED: TAR ( 414) 386 56.0 1.5e-07 XP_016856357 (OMIM: 605078,612069) PREDICTED: TAR ( 414) 386 56.0 1.5e-07 XP_016856354 (OMIM: 605078,612069) PREDICTED: TAR ( 414) 386 56.0 1.5e-07 XP_016856352 (OMIM: 605078,612069) PREDICTED: TAR ( 414) 386 56.0 1.5e-07 XP_016856356 (OMIM: 605078,612069) PREDICTED: TAR ( 414) 386 56.0 1.5e-07 NP_031401 (OMIM: 605078,612069) TAR DNA-binding pr ( 414) 386 56.0 1.5e-07 XP_016856355 (OMIM: 605078,612069) PREDICTED: TAR ( 414) 386 56.0 1.5e-07 XP_016879636 (OMIM: 607897) PREDICTED: RNA-binding ( 315) 334 50.0 7.2e-06 XP_016882071 (OMIM: 607430) PREDICTED: DAZ-associa ( 327) 290 45.2 0.00021 XP_011526209 (OMIM: 607430) PREDICTED: DAZ-associa ( 548) 293 45.9 0.00022 XP_011526208 (OMIM: 607430) PREDICTED: DAZ-associa ( 549) 293 45.9 0.00022 XP_005259588 (OMIM: 607430) PREDICTED: DAZ-associa ( 406) 290 45.3 0.00024 XP_011526210 (OMIM: 607430) PREDICTED: DAZ-associa ( 521) 290 45.5 0.00027 XP_011526211 (OMIM: 607430) PREDICTED: DAZ-associa ( 521) 290 45.5 0.00027 >>NP_002129 (OMIM: 601324) heterogeneous nuclear ribonuc (306 aa) initn: 2042 init1: 2042 opt: 2042 Z-score: 1248.3 bits: 239.1 E(85289): 8.6e-63 Smith-Waterman score: 2042; 100.0% identity (100.0% similar) in 306 aa overlap (1-306:1-306) 10 20 30 40 50 60 pF1KB8 MSEEQFGGDGAAAAATAAVGGSAGEQEGAMVAATQGAAAAAGSGAGTGGGTASGGTEGGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 MSEEQFGGDGAAAAATAAVGGSAGEQEGAMVAATQGAAAAAGSGAGTGGGTASGGTEGGS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 AESEGAKIDASKNEEDEGHSNSSPRHSEAATAQREEWKMFIGGLSWDTTKKDLKDYFSKF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 AESEGAKIDASKNEEDEGHSNSSPRHSEAATAQREEWKMFIGGLSWDTTKKDLKDYFSKF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 GEVVDCTLKLDPITGRSRGFGFVLFKESESVDKVMDQKEHKLNGKVIDPKRAKAMKTKEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 GEVVDCTLKLDPITGRSRGFGFVLFKESESVDKVMDQKEHKLNGKVIDPKRAKAMKTKEP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 VKKIFVGGLSPDTPEEKIREYFGGFGEVESIELPMDNKTNKRRGFCFITFKEEEPVKKIM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 VKKIFVGGLSPDTPEEKIREYFGGFGEVESIELPMDNKTNKRRGFCFITFKEEEPVKKIM 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 EKKYHNVGLSKCEIKVAMSKEQYQQQQQWGSRGGFAGRARGRGGDQQSGYGKVSRRGGHQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 EKKYHNVGLSKCEIKVAMSKEQYQQQQQWGSRGGFAGRARGRGGDQQSGYGKVSRRGGHQ 250 260 270 280 290 300 pF1KB8 NSYKPY :::::: NP_002 NSYKPY >>NP_112738 (OMIM: 601324) heterogeneous nuclear ribonuc (355 aa) initn: 2309 init1: 1886 opt: 1887 Z-score: 1154.9 bits: 222.0 E(85289): 1.4e-57 Smith-Waterman score: 1887; 93.8% identity (96.4% similar) in 307 aa overlap (1-303:1-307) 10 20 30 40 50 60 pF1KB8 MSEEQFGGDGAAAAATAAVGGSAGEQEGAMVAATQGAAAAAGSGAGTGGGTASGGTEGGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_112 MSEEQFGGDGAAAAATAAVGGSAGEQEGAMVAATQGAAAAAGSGAGTGGGTASGGTEGGS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 AESEGAKIDASKNEEDEGHSNSSPRHSEAATAQREEWKMFIGGLSWDTTKKDLKDYFSKF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_112 AESEGAKIDASKNEEDEGHSNSSPRHSEAATAQREEWKMFIGGLSWDTTKKDLKDYFSKF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 GEVVDCTLKLDPITGRSRGFGFVLFKESESVDKVMDQKEHKLNGKVIDPKRAKAMKTKEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_112 GEVVDCTLKLDPITGRSRGFGFVLFKESESVDKVMDQKEHKLNGKVIDPKRAKAMKTKEP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 VKKIFVGGLSPDTPEEKIREYFGGFGEVESIELPMDNKTNKRRGFCFITFKEEEPVKKIM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_112 VKKIFVGGLSPDTPEEKIREYFGGFGEVESIELPMDNKTNKRRGFCFITFKEEEPVKKIM 190 200 210 220 230 240 250 260 270 280 290 pF1KB8 EKKYHNVGLSKCEIKVAMSKEQYQQQQQWGSRGGFAGRARGRGG----DQQSGYGKVSRR :::::::::::::::::::::::::::::::::::::::::::: . ..::.. . NP_112 EKKYHNVGLSKCEIKVAMSKEQYQQQQQWGSRGGFAGRARGRGGGPSQNWNQGYSNYWNQ 250 260 270 280 290 300 300 pF1KB8 GGHQNSYKPY : . .: NP_112 GYGNYGYNSQGYGGYGGYDYTGYNNYYGYGDYSNQQSGYGKVSRRGGHQNSYKPY 310 320 330 340 350 >>NP_001003810 (OMIM: 601324) heterogeneous nuclear ribo (287 aa) initn: 1438 init1: 1438 opt: 1487 Z-score: 916.5 bits: 177.6 E(85289): 2.6e-44 Smith-Waterman score: 1863; 93.8% identity (93.8% similar) in 306 aa overlap (1-306:1-287) 10 20 30 40 50 60 pF1KB8 MSEEQFGGDGAAAAATAAVGGSAGEQEGAMVAATQGAAAAAGSGAGTGGGTASGGTEGGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSEEQFGGDGAAAAATAAVGGSAGEQEGAMVAATQGAAAAAGSGAGTGGGTASGGTEGGS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 AESEGAKIDASKNEEDEGHSNSSPRHSEAATAQREEWKMFIGGLSWDTTKKDLKDYFSKF :::::::::::::::::: ::::::::::::::::::::::: NP_001 AESEGAKIDASKNEEDEG-------------------KMFIGGLSWDTTKKDLKDYFSKF 70 80 90 100 130 140 150 160 170 180 pF1KB8 GEVVDCTLKLDPITGRSRGFGFVLFKESESVDKVMDQKEHKLNGKVIDPKRAKAMKTKEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GEVVDCTLKLDPITGRSRGFGFVLFKESESVDKVMDQKEHKLNGKVIDPKRAKAMKTKEP 110 120 130 140 150 160 190 200 210 220 230 240 pF1KB8 VKKIFVGGLSPDTPEEKIREYFGGFGEVESIELPMDNKTNKRRGFCFITFKEEEPVKKIM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VKKIFVGGLSPDTPEEKIREYFGGFGEVESIELPMDNKTNKRRGFCFITFKEEEPVKKIM 170 180 190 200 210 220 250 260 270 280 290 300 pF1KB8 EKKYHNVGLSKCEIKVAMSKEQYQQQQQWGSRGGFAGRARGRGGDQQSGYGKVSRRGGHQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EKKYHNVGLSKCEIKVAMSKEQYQQQQQWGSRGGFAGRARGRGGDQQSGYGKVSRRGGHQ 230 240 250 260 270 280 pF1KB8 NSYKPY :::::: NP_001 NSYKPY >>NP_112737 (OMIM: 601324) heterogeneous nuclear ribonuc (336 aa) initn: 2054 init1: 1269 opt: 1332 Z-score: 823.1 bits: 160.5 E(85289): 4.1e-39 Smith-Waterman score: 1708; 87.6% identity (90.2% similar) in 307 aa overlap (1-303:1-288) 10 20 30 40 50 60 pF1KB8 MSEEQFGGDGAAAAATAAVGGSAGEQEGAMVAATQGAAAAAGSGAGTGGGTASGGTEGGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_112 MSEEQFGGDGAAAAATAAVGGSAGEQEGAMVAATQGAAAAAGSGAGTGGGTASGGTEGGS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 AESEGAKIDASKNEEDEGHSNSSPRHSEAATAQREEWKMFIGGLSWDTTKKDLKDYFSKF :::::::::::::::::: ::::::::::::::::::::::: NP_112 AESEGAKIDASKNEEDEG-------------------KMFIGGLSWDTTKKDLKDYFSKF 70 80 90 100 130 140 150 160 170 180 pF1KB8 GEVVDCTLKLDPITGRSRGFGFVLFKESESVDKVMDQKEHKLNGKVIDPKRAKAMKTKEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_112 GEVVDCTLKLDPITGRSRGFGFVLFKESESVDKVMDQKEHKLNGKVIDPKRAKAMKTKEP 110 120 130 140 150 160 190 200 210 220 230 240 pF1KB8 VKKIFVGGLSPDTPEEKIREYFGGFGEVESIELPMDNKTNKRRGFCFITFKEEEPVKKIM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_112 VKKIFVGGLSPDTPEEKIREYFGGFGEVESIELPMDNKTNKRRGFCFITFKEEEPVKKIM 170 180 190 200 210 220 250 260 270 280 290 pF1KB8 EKKYHNVGLSKCEIKVAMSKEQYQQQQQWGSRGGFAGRARGRGG----DQQSGYGKVSRR :::::::::::::::::::::::::::::::::::::::::::: . ..::.. . NP_112 EKKYHNVGLSKCEIKVAMSKEQYQQQQQWGSRGGFAGRARGRGGGPSQNWNQGYSNYWNQ 230 240 250 260 270 280 300 pF1KB8 GGHQNSYKPY : . .: NP_112 GYGNYGYNSQGYGGYGGYDYTGYNNYYGYGDYSNQQSGYGKVSRRGGHQNSYKPY 290 300 310 320 330 >>NP_001193929 (OMIM: 607137,609115) heterogeneous nucle (363 aa) initn: 1145 init1: 934 opt: 1071 Z-score: 666.7 bits: 131.7 E(85289): 2.1e-30 Smith-Waterman score: 1081; 65.6% identity (82.8% similar) in 250 aa overlap (63-306:133-363) 40 50 60 70 80 90 pF1KB8 ATQGAAAAAGSGAGTGGGTASGGTEGGSAESEGAKIDASKNEEDEGHSNSSPRHSEAATA .::.::.::::..:.: NP_001 AATRTARQHPPADSSVTMEDMNEYSNIEEFAEGSKINASKNQQDDG-------------- 110 120 130 140 100 110 120 130 140 150 pF1KB8 QREEWKMFIGGLSWDTTKKDLKDYFSKFGEVVDCTLKLDPITGRSRGFGFVLFKESESVD :::::::::::.:::: .:.:.::::::::.: ::.:::::::::::::.. ::: NP_001 -----KMFIGGLSWDTSKKDLTEYLSRFGEVVDCTIKTDPVTGRSRGFGFVLFKDAASVD 150 160 170 180 190 200 160 170 180 190 200 210 pF1KB8 KVMDQKEHKLNGKVIDPKRAKAMKTKEPVKKIFVGGLSPDTPEEKIREYFGGFGEVESIE ::.. :::::.::.::::::::.: ::: ::.::::::::: ::.:.::::.:::.:.:: NP_001 KVLELKEHKLDGKLIDPKRAKALKGKEPPKKVFVGGLSPDTSEEQIKEYFGAFGEIENIE 210 220 230 240 250 260 220 230 240 250 260 270 pF1KB8 LPMDNKTNKRRGFCFITFKEEEPVKKIMEKKYHNVGLSKCEIKVAMSKEQY--QQQQQWG ::::.:::.::::::::. .::::::..:..::..: .:::::::. :: : ::::: : NP_001 LPMDTKTNERRGFCFITYTDEEPVKKLLESRYHQIGSGKCEIKVAQPKEVYRQQQQQQKG 270 280 290 300 310 320 280 290 300 pF1KB8 SRGGFAGR---ARGRGGDQQSGYGKVSRRGG-HQNSYKPY .::. :: .:::: ::: :::.:: :: :::.:.:: NP_001 GRGAAAGGRGGTRGRGRGQQSTYGKASRGGGNHQNNYQPY 330 340 350 360 >>NP_004490 (OMIM: 602688) heterogeneous nuclear ribonuc (285 aa) initn: 1075 init1: 474 opt: 1065 Z-score: 664.1 bits: 130.9 E(85289): 3e-30 Smith-Waterman score: 1124; 60.5% identity (79.4% similar) in 296 aa overlap (22-306:12-285) 10 20 30 40 50 pF1KB8 MSEEQFGGDGAAAAATAAVGGSAGEQEGAMVAATQGAA-AAAGSGAGTGGGTASGGTEGG ..: :.. :. .: . :.::.::..:.: :... .: NP_004 MSEAGEEQPMETTGATENGHEAVPEGESPAGAGTGAAAGAGGATAAPPSG 10 20 30 40 50 60 70 80 90 100 110 pF1KB8 SAE-SEGAKIDASKNEEDEGHSNSSPRHSEAATAQREEWKMFIGGLSWDTTKKDLKDYFS . . .:: .:.::::::: : :::.:::::::.::::::::. NP_004 NQNGAEGDQINASKNEEDAG-------------------KMFVGGLSWDTSKKDLKDYFT 60 70 80 90 120 130 140 150 160 170 pF1KB8 KFGEVVDCTLKLDPITGRSRGFGFVLFKESESVDKVMDQKEHKLNGKVIDPKRAKAMKTK :::::::::.:.:: :::::::::.:::.. ::.::.:::::.:.:.:::::.: ::: : NP_004 KFGEVVDCTIKMDPNTGRSRGFGFILFKDAASVEKVLDQKEHRLDGRVIDPKKAMAMK-K 100 110 120 130 140 150 180 190 200 210 220 230 pF1KB8 EPVKKIFVGGLSPDTPEEKIREYFGGFGEVESIELPMDNKTNKRRGFCFITFKEEEPVKK .::::::::::.:.. ::::::::: :::.:.:::::: : :::::: :::::::::::: NP_004 DPVKKIFVGGLNPEATEEKIREYFGEFGEIEAIELPMDPKLNKRRGFVFITFKEEEPVKK 160 170 180 190 200 210 240 250 260 270 280 pF1KB8 IMEKKYHNVGLSKCEIKVAMSKEQYQQQQQWGSRGGFAGRARGR---------GGDQQSG ..:::.:.:. ::::::::. :: ::::: .:: :: ..: :: ::. ... NP_004 VLEKKFHTVSGSKCEIKVAQPKEVYQQQQ-YGS-GGRGNRNRGNRGSGGGGGGGGQGSTN 220 230 240 250 260 290 300 pF1KB8 YGKVSRRGGHQNSYKPY ::: .:::::::.:::: NP_004 YGKSQRRGGHQNNYKPY 270 280 >>NP_112556 (OMIM: 602688) heterogeneous nuclear ribonuc (332 aa) initn: 1105 init1: 474 opt: 988 Z-score: 617.4 bits: 122.5 E(85289): 1.2e-27 Smith-Waterman score: 1061; 58.5% identity (77.6% similar) in 299 aa overlap (22-305:12-288) 10 20 30 40 50 pF1KB8 MSEEQFGGDGAAAAATAAVGGSAGEQEGAMVAATQGAA-AAAGSGAGTGGGTASGGTEGG ..: :.. :. .: . :.::.::..:.: :... .: NP_112 MSEAGEEQPMETTGATENGHEAVPEGESPAGAGTGAAAGAGGATAAPPSG 10 20 30 40 50 60 70 80 90 100 110 pF1KB8 SAE-SEGAKIDASKNEEDEGHSNSSPRHSEAATAQREEWKMFIGGLSWDTTKKDLKDYFS . . .:: .:.::::::: : :::.:::::::.::::::::. NP_112 NQNGAEGDQINASKNEEDAG-------------------KMFVGGLSWDTSKKDLKDYFT 60 70 80 90 120 130 140 150 160 170 pF1KB8 KFGEVVDCTLKLDPITGRSRGFGFVLFKESESVDKVMDQKEHKLNGKVIDPKRAKAMKTK :::::::::.:.:: :::::::::.:::.. ::.::.:::::.:.:.:::::.: ::: : NP_112 KFGEVVDCTIKMDPNTGRSRGFGFILFKDAASVEKVLDQKEHRLDGRVIDPKKAMAMK-K 100 110 120 130 140 150 180 190 200 210 220 230 pF1KB8 EPVKKIFVGGLSPDTPEEKIREYFGGFGEVESIELPMDNKTNKRRGFCFITFKEEEPVKK .::::::::::.:.. ::::::::: :::.:.:::::: : :::::: :::::::::::: NP_112 DPVKKIFVGGLNPEATEEKIREYFGEFGEIEAIELPMDPKLNKRRGFVFITFKEEEPVKK 160 170 180 190 200 210 240 250 260 270 280 pF1KB8 IMEKKYHNVGLSKCEIKVAMSKEQYQQQQQWGSRGGFAGRARGR---------GGDQQS- ..:::.:.:. ::::::::. :: ::::: .:: :: ..: :: ::..:: NP_112 VLEKKFHTVSGSKCEIKVAQPKEVYQQQQ-YGS-GGRGNRNRGNRGSGGGGGGGGQSQSW 220 230 240 250 260 290 300 pF1KB8 --GYGKVSRRG-GHQNSYKPY :::. .: :.:..: : NP_112 NQGYGNYWNQGYGYQQGYGPGYGGYDYSPYGYYGYGPGYDYSQGSTNYGKSQRRGGHQNN 270 280 290 300 310 320 >>NP_112740 (OMIM: 607137,609115) heterogeneous nuclear (420 aa) initn: 1107 init1: 934 opt: 988 Z-score: 616.5 bits: 122.6 E(85289): 1.3e-27 Smith-Waterman score: 1007; 60.8% identity (80.4% similar) in 250 aa overlap (63-302:133-363) 40 50 60 70 80 90 pF1KB8 ATQGAAAAAGSGAGTGGGTASGGTEGGSAESEGAKIDASKNEEDEGHSNSSPRHSEAATA .::.::.::::..:.: NP_112 AATRTARQHPPADSSVTMEDMNEYSNIEEFAEGSKINASKNQQDDG-------------- 110 120 130 140 100 110 120 130 140 150 pF1KB8 QREEWKMFIGGLSWDTTKKDLKDYFSKFGEVVDCTLKLDPITGRSRGFGFVLFKESESVD :::::::::::.:::: .:.:.::::::::.: ::.:::::::::::::.. ::: NP_112 -----KMFIGGLSWDTSKKDLTEYLSRFGEVVDCTIKTDPVTGRSRGFGFVLFKDAASVD 150 160 170 180 190 200 160 170 180 190 200 210 pF1KB8 KVMDQKEHKLNGKVIDPKRAKAMKTKEPVKKIFVGGLSPDTPEEKIREYFGGFGEVESIE ::.. :::::.::.::::::::.: ::: ::.::::::::: ::.:.::::.:::.:.:: NP_112 KVLELKEHKLDGKLIDPKRAKALKGKEPPKKVFVGGLSPDTSEEQIKEYFGAFGEIENIE 210 220 230 240 250 260 220 230 240 250 260 pF1KB8 LPMDNKTNKRRGFCFITFKEEEPVKKIMEKKYHNVGLSKCEIKVAMSKEQYQQQQQW--- ::::.:::.::::::::. .::::::..:..::..: .:::::::. :: :.:::: NP_112 LPMDTKTNERRGFCFITYTDEEPVKKLLESRYHQIGSGKCEIKVAQPKEVYRQQQQQQKG 270 280 290 300 310 320 270 280 290 300 pF1KB8 ------GSRGGFAGRARGRGGDQQSGYGKVSRRG-GHQNSYKPY :.::: ::.::.: . ..:... .: :. :: NP_112 GRGAAAGGRGGTRGRGRGQGQNWNQGFNNYYDQGYGNYNSAYGGDQNYSGYGGYDYTGYN 330 340 350 360 370 380 NP_112 YGNYGYGQGYADYSGQQSTYGKASRGGGNHQNNYQPY 390 400 410 420 >>NP_001317180 (OMIM: 605372) heterogeneous nuclear ribo (331 aa) initn: 675 init1: 333 opt: 606 Z-score: 388.9 bits: 80.2 E(85289): 6.4e-15 Smith-Waterman score: 606; 39.5% identity (70.8% similar) in 243 aa overlap (69-303:13-249) 40 50 60 70 80 90 pF1KB8 AAAGSGAGTGGGTASGGTEGGSAESEGAKIDASKNEEDEGHSNSSPRHSEAATAQREEWK :... .. .:. . .:.. : : NP_001 MEVKPPPGRPQPDSGRRRRRRGEEGHDPKEPEQLR------K 10 20 30 100 110 120 130 140 150 pF1KB8 MFIGGLSWDTTKKDLKDYFSKFGEVVDCTLKLDPITGRSRGFGFVLFKESESVDKVMDQK .::::::..:: .:...: :.: ..::.. :: : :::::::: .. : :: .: . NP_001 LFIGGLSFETTDDSLREHFEKWGTLTDCVVMRDPQTKRSRGFGFVTYSCVEEVDAAMCAR 40 50 60 70 80 90 160 170 180 190 200 210 pF1KB8 EHKLNGKVIDPKRAKAMKTK-EP-----VKKIFVGGLSPDTPEEKIREYFGGFGEVESIE ::..:.:..:::: . . . .: ::::::::.. :: : ..:.:: .:..:.:: NP_001 PHKVDGRVVEPKRAVSREDSVKPGAHLTVKKIFVGGIKEDTEEYNLRDYFEKYGKIETIE 100 110 120 130 140 150 220 230 240 250 260 270 pF1KB8 LPMDNKTNKRRGFCFITFKEEEPVKKIMEKKYHNVGLSKCEIKVAMSKEQYQQQQQWGSR . : ...:.::: :.:: ... : ::. .:::... .::.: :.::...:. . .: NP_001 VMEDRQSGKKRGFAFVTFDDHDTVDKIVVQKYHTINGHNCEVKKALSKQEMQSAGSQRGR 160 170 180 190 200 210 280 290 300 pF1KB8 GGFAGRARGRGGDQQSGYGKVSRRG--GHQNSYKPY :: .: ::::. .: :. .: : : ...: NP_001 GGGSGNFMGRGGNFGGGGGNFGRGGNFGGRGGYGGGGGGSRGSYGGGDGGYNGFGGDGNY 220 230 240 250 260 270 NP_001 GGGGNYNDFGNYSGQQQSNYGPMKGGSFGGRSSGSPYGGGYGSGGGSGGYGSRRF 280 290 300 310 320 330 >>NP_001317179 (OMIM: 605372) heterogeneous nuclear ribo (331 aa) initn: 675 init1: 333 opt: 606 Z-score: 388.9 bits: 80.2 E(85289): 6.4e-15 Smith-Waterman score: 606; 39.5% identity (70.8% similar) in 243 aa overlap (69-303:13-249) 40 50 60 70 80 90 pF1KB8 AAAGSGAGTGGGTASGGTEGGSAESEGAKIDASKNEEDEGHSNSSPRHSEAATAQREEWK :... .. .:. . .:.. : : NP_001 MEVKPPPGRPQPDSGRRRRRRGEEGHDPKEPEQLR------K 10 20 30 100 110 120 130 140 150 pF1KB8 MFIGGLSWDTTKKDLKDYFSKFGEVVDCTLKLDPITGRSRGFGFVLFKESESVDKVMDQK .::::::..:: .:...: :.: ..::.. :: : :::::::: .. : :: .: . NP_001 LFIGGLSFETTDDSLREHFEKWGTLTDCVVMRDPQTKRSRGFGFVTYSCVEEVDAAMCAR 40 50 60 70 80 90 160 170 180 190 200 210 pF1KB8 EHKLNGKVIDPKRAKAMKTK-EP-----VKKIFVGGLSPDTPEEKIREYFGGFGEVESIE ::..:.:..:::: . . . .: ::::::::.. :: : ..:.:: .:..:.:: NP_001 PHKVDGRVVEPKRAVSREDSVKPGAHLTVKKIFVGGIKEDTEEYNLRDYFEKYGKIETIE 100 110 120 130 140 150 220 230 240 250 260 270 pF1KB8 LPMDNKTNKRRGFCFITFKEEEPVKKIMEKKYHNVGLSKCEIKVAMSKEQYQQQQQWGSR . : ...:.::: :.:: ... : ::. .:::... .::.: :.::...:. . .: NP_001 VMEDRQSGKKRGFAFVTFDDHDTVDKIVVQKYHTINGHNCEVKKALSKQEMQSAGSQRGR 160 170 180 190 200 210 280 290 300 pF1KB8 GGFAGRARGRGGDQQSGYGKVSRRG--GHQNSYKPY :: .: ::::. .: :. .: : : ...: NP_001 GGGSGNFMGRGGNFGGGGGNFGRGGNFGGRGGYGGGGGGSRGSYGGGDGGYNGFGGDGNY 220 230 240 250 260 270 NP_001 GGGGNYNDFGNYSGQQQSNYGPMKGGSFGGRSSGSPYGGGYGSGGGSGGYGSRRF 280 290 300 310 320 330 306 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 11:18:24 2016 done: Fri Nov 4 11:18:25 2016 Total Scan time: 7.260 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]