FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8301, 478 aa 1>>>pF1KB8301 478 - 478 aa - 478 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.7765+/-0.000825; mu= 15.2989+/- 0.050 mean_var=73.0682+/-14.305, 0's: 0 Z-trim(107.9): 10 B-trim: 12 in 1/50 Lambda= 0.150041 statistics sampled from 9868 (9874) to 9868 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.69), E-opt: 0.2 (0.303), width: 16 Scan time: 3.090 The best scores are: opt bits E(32554) CCDS77678.1 MIEF1 gene_id:54471|Hs108|chr22 ( 478) 3188 699.4 2.1e-201 CCDS13995.1 MIEF1 gene_id:54471|Hs108|chr22 ( 463) 2866 629.7 2e-180 CCDS11193.1 MIEF2 gene_id:125170|Hs108|chr17 ( 454) 925 209.5 5.9e-54 CCDS45624.1 MIEF2 gene_id:125170|Hs108|chr17 ( 465) 925 209.6 6e-54 CCDS45625.1 MIEF2 gene_id:125170|Hs108|chr17 ( 205) 263 66.1 4e-11 >>CCDS77678.1 MIEF1 gene_id:54471|Hs108|chr22 (478 aa) initn: 3188 init1: 3188 opt: 3188 Z-score: 3729.2 bits: 699.4 E(32554): 2.1e-201 Smith-Waterman score: 3188; 99.6% identity (100.0% similar) in 478 aa overlap (1-478:1-478) 10 20 30 40 50 60 pF1KB8 MAGAGERKGKKDDNGIGTAIDFVLSNARLVLGVGGAAMLGIATLAVKRMYDRAISAPTSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS77 MAGAGERKGKKDDNGIGTAIDFVLSNARLVLGVGGAAMLGIATLAVKRMYDRAISAPTSP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 TRLSHSGKRSWEEPNWMGSPRLLNRDMKTGLSRSLQTLPTDSSTFDTDTFCPPRPKPVAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS77 TRLSHSGKRSWEEPNWMGSPRLLNRDMKTGLSRSLQTLPTDSSTFDTDTFCPPRPKPVAR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 KGQVDLKKSRLRMSLQEKLLTYYRNRAAIPAGEQARAKQAAVDICAELRSFLRAKLPDMP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS77 KGQVDLKKSRLRMSLQEKLLTYYRNRAAIPAGEQARAKQAAVDICAELRSFLRAKLPDMP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 LRDMYLSGSLYDDLQVVTADHIQLIVPLVLEQNLWSCIPGEDTIMNVPGFFLVRRENPEY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS77 LRDMYLSGSLYDDLQVVTADHIQLIVPLVLEQNLWSCIPGEDTIMNVPGFFLVRRENPEY 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 FPRGSSYWDRCVVGGYLSPKTVANTFEKVVAGSINWPAIGSLLDYVIRPAPPPEALTLEV :::::::::::::::::::::::.:::::::::::::::::::::::::::::::::::: CCDS77 FPRGSSYWDRCVVGGYLSPKTVADTFEKVVAGSINWPAIGSLLDYVIRPAPPPEALTLEV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 QYERDKHLFIDFLPSVTLGDTVLVAKPHRLAQYDNLWRLSLRPAETARLRALDQADSGCR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS77 QYERDKHLFIDFLPSVTLGDTVLVAKPHRLAQYDNLWRLSLRPAETARLRALDQADSGCR 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 SLCLKILKAICKSTPALGHLTASQLTNVILHLAQEEADWSPDMLADRFLQALRGLISYLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS77 SLCLKILKAICKSTPALGHLTASQLTNVILHLAQEEADWSPDMLADRFLQALRGLISYLE 370 380 390 400 410 420 430 440 450 460 470 pF1KB8 AGVLPSALNPKDKALKERSLRYQVRMMEVDSRLNVSWKIQSLVGVWWPCFLPRQALLF :::::::::::::::::::::.:::::::::::::::::::::::::::::::::::: CCDS77 AGVLPSALNPKDKALKERSLRHQVRMMEVDSRLNVSWKIQSLVGVWWPCFLPRQALLF 430 440 450 460 470 >>CCDS13995.1 MIEF1 gene_id:54471|Hs108|chr22 (463 aa) initn: 2866 init1: 2866 opt: 2866 Z-score: 3352.8 bits: 629.7 E(32554): 2e-180 Smith-Waterman score: 2866; 99.8% identity (100.0% similar) in 431 aa overlap (1-431:1-431) 10 20 30 40 50 60 pF1KB8 MAGAGERKGKKDDNGIGTAIDFVLSNARLVLGVGGAAMLGIATLAVKRMYDRAISAPTSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 MAGAGERKGKKDDNGIGTAIDFVLSNARLVLGVGGAAMLGIATLAVKRMYDRAISAPTSP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 TRLSHSGKRSWEEPNWMGSPRLLNRDMKTGLSRSLQTLPTDSSTFDTDTFCPPRPKPVAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 TRLSHSGKRSWEEPNWMGSPRLLNRDMKTGLSRSLQTLPTDSSTFDTDTFCPPRPKPVAR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 KGQVDLKKSRLRMSLQEKLLTYYRNRAAIPAGEQARAKQAAVDICAELRSFLRAKLPDMP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 KGQVDLKKSRLRMSLQEKLLTYYRNRAAIPAGEQARAKQAAVDICAELRSFLRAKLPDMP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 LRDMYLSGSLYDDLQVVTADHIQLIVPLVLEQNLWSCIPGEDTIMNVPGFFLVRRENPEY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 LRDMYLSGSLYDDLQVVTADHIQLIVPLVLEQNLWSCIPGEDTIMNVPGFFLVRRENPEY 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 FPRGSSYWDRCVVGGYLSPKTVANTFEKVVAGSINWPAIGSLLDYVIRPAPPPEALTLEV :::::::::::::::::::::::.:::::::::::::::::::::::::::::::::::: CCDS13 FPRGSSYWDRCVVGGYLSPKTVADTFEKVVAGSINWPAIGSLLDYVIRPAPPPEALTLEV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 QYERDKHLFIDFLPSVTLGDTVLVAKPHRLAQYDNLWRLSLRPAETARLRALDQADSGCR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 QYERDKHLFIDFLPSVTLGDTVLVAKPHRLAQYDNLWRLSLRPAETARLRALDQADSGCR 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 SLCLKILKAICKSTPALGHLTASQLTNVILHLAQEEADWSPDMLADRFLQALRGLISYLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 SLCLKILKAICKSTPALGHLTASQLTNVILHLAQEEADWSPDMLADRFLQALRGLISYLE 370 380 390 400 410 420 430 440 450 460 470 pF1KB8 AGVLPSALNPKDKALKERSLRYQVRMMEVDSRLNVSWKIQSLVGVWWPCFLPRQALLF ::::::::::: CCDS13 AGVLPSALNPKVNLFAELTPEEIDELGYTLYCSLSEPEVLLQT 430 440 450 460 >>CCDS11193.1 MIEF2 gene_id:125170|Hs108|chr17 (454 aa) initn: 1090 init1: 585 opt: 925 Z-score: 1082.2 bits: 209.5 E(32554): 5.9e-54 Smith-Waterman score: 1115; 45.2% identity (71.6% similar) in 436 aa overlap (1-430:1-423) 10 20 30 40 50 pF1KB8 MAGAGERKGKK-DDNGIGTAIDFVLSNARLVLGVGGAAMLGIATLAVKRMYDRAISAPTS :: ....::. .:.:.:. .::.:.::::::::::::.::::::::::. ::: :: CCDS11 MAEFSQKRGKRRSDEGLGSMVDFLLANARLVLGVGGAAVLGIATLAVKRFIDRA----TS 10 20 30 40 50 60 70 80 90 100 110 pF1KB8 PTRLSHSGKRSWEEPNWM-GSPRLLNRDMKTGLSRSLQTLPTDSSTFDTDTFCPPRPKPV : . . ::.: . . ..:.: : ..::. . : .::. . . :. : CCDS11 PRDEDDTKADSWKELSLLKATPHLQPRPPPAALSQPVLPLAPSSSAPEGPAETDPEVTP- 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB8 ARKGQVDLKKSRLRMSLQEKLLTYYRNRAAIPAGEQARAKQAAVDICAELRSFLRAKLPD :.. . . : ..:::.::.. :.:..:::.. : ::: : :: ::....:.:.:. CCDS11 ----QLS-SPAPLCLTLQERLLAFERDRVTIPAAQVALAKQLAGDIALELQAYFRSKFPE 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB8 MPLRDMYLSGSLYDDLQVVTADHIQLIVPLVLEQNLWSCIPGEDTIMNVPGFFLVRRENP .:. . .: ::: ::. .:::..:.:::::: .::: .:: ::. : . ::: . CCDS11 LPFGAFVPGGPLYDGLQAGAADHVRLLVPLVLEPGLWSLVPGVDTVARDPRCWAVRRTQL 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB8 EYFPRGSSYWDRCVVGGYLSPKTVANTFEKVVAGSINWPAIGSLLDYVIRPAPPPEALTL :. ::::: ::: .:::::: ... . ..:..:.:.::::::::: .:::. : : : CCDS11 EFCPRGSSPWDRFLVGGYLSSRVLLELLRKALAASVNWPAIGSLLGCLIRPSMASEELLL 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB8 EVQYERDKHLFIDFL---PSVTLGDTVLVAKPHR-LAQYDNLWRLSLRPAETARLRALDQ :::.:: . : . : :.: : .:.: : . :: ::: .: :.:.:::::::. CCDS11 EVQHERLE-LTVAVLVAVPGVDADDRLLLAWPLEGLA--GNLWLQDLYPVEAARLRALDD 300 310 320 330 340 360 370 380 390 400 410 pF1KB8 ADSGCRSLCLKILKAICKSTPALGHLTASQLTNVILHLAQEEADWSPDMLADRFLQALRG :.: : : .: :.:.. :::.: ..::.:.:.:.....::. . :..::::::. CCDS11 HDAGTRRRLLLLLCAVCRGCSALGQLGRGHLTQVVLRLGEDNVDWTEEALGERFLQALEL 350 360 370 380 390 400 420 430 440 450 460 470 pF1KB8 LISYLEAGVLPSALNPKDKALKERSLRYQVRMMEVDSRLNVSWKIQSLVGVWWPCFLPRQ ::. :: . :: .:: CCDS11 LIGSLEQASLPCHFNPSVNLFSSLREEEIDDIGYALYSGLQEPEGLL 410 420 430 440 450 >>CCDS45624.1 MIEF2 gene_id:125170|Hs108|chr17 (465 aa) initn: 1090 init1: 585 opt: 925 Z-score: 1082.0 bits: 209.6 E(32554): 6e-54 Smith-Waterman score: 1115; 45.2% identity (71.6% similar) in 436 aa overlap (1-430:12-434) 10 20 30 40 pF1KB8 MAGAGERKGKK-DDNGIGTAIDFVLSNARLVLGVGGAAMLGIATLAVKR :: ....::. .:.:.:. .::.:.::::::::::::.:::::::::: CCDS45 MGLSPNLDRQTMAEFSQKRGKRRSDEGLGSMVDFLLANARLVLGVGGAAVLGIATLAVKR 10 20 30 40 50 60 50 60 70 80 90 100 pF1KB8 MYDRAISAPTSPTRLSHSGKRSWEEPNWM-GSPRLLNRDMKTGLSRSLQTLPTDSSTFDT . ::: ::: . . ::.: . . ..:.: : ..::. . : .::. . CCDS45 FIDRA----TSPRDEDDTKADSWKELSLLKATPHLQPRPPPAALSQPVLPLAPSSSAPEG 70 80 90 100 110 110 120 130 140 150 160 pF1KB8 DTFCPPRPKPVARKGQVDLKKSRLRMSLQEKLLTYYRNRAAIPAGEQARAKQAAVDICAE . :. : :.. . . : ..:::.::.. :.:..:::.. : ::: : :: : CCDS45 PAETDPEVTP-----QLS-SPAPLCLTLQERLLAFERDRVTIPAAQVALAKQLAGDIALE 120 130 140 150 160 170 170 180 190 200 210 220 pF1KB8 LRSFLRAKLPDMPLRDMYLSGSLYDDLQVVTADHIQLIVPLVLEQNLWSCIPGEDTIMNV :....:.:.:..:. . .: ::: ::. .:::..:.:::::: .::: .:: ::. CCDS45 LQAYFRSKFPELPFGAFVPGGPLYDGLQAGAADHVRLLVPLVLEPGLWSLVPGVDTVARD 180 190 200 210 220 230 230 240 250 260 270 280 pF1KB8 PGFFLVRRENPEYFPRGSSYWDRCVVGGYLSPKTVANTFEKVVAGSINWPAIGSLLDYVI : . ::: . :. ::::: ::: .:::::: ... . ..:..:.:.::::::::: .: CCDS45 PRCWAVRRTQLEFCPRGSSPWDRFLVGGYLSSRVLLELLRKALAASVNWPAIGSLLGCLI 240 250 260 270 280 290 290 300 310 320 330 340 pF1KB8 RPAPPPEALTLEVQYERDKHLFIDFL---PSVTLGDTVLVAKPHR-LAQYDNLWRLSLRP ::. : : ::::.:: . : . : :.: : .:.: : . :: ::: .: : CCDS45 RPSMASEELLLEVQHERLE-LTVAVLVAVPGVDADDRLLLAWPLEGLA--GNLWLQDLYP 300 310 320 330 340 350 360 370 380 390 400 pF1KB8 AETARLRALDQADSGCRSLCLKILKAICKSTPALGHLTASQLTNVILHLAQEEADWSPDM .:.:::::::. :.: : : .: :.:.. :::.: ..::.:.:.:.....::. . CCDS45 VEAARLRALDDHDAGTRRRLLLLLCAVCRGCSALGQLGRGHLTQVVLRLGEDNVDWTEEA 350 360 370 380 390 400 410 420 430 440 450 460 pF1KB8 LADRFLQALRGLISYLEAGVLPSALNPKDKALKERSLRYQVRMMEVDSRLNVSWKIQSLV :..::::::. ::. :: . :: .:: CCDS45 LGERFLQALELLIGSLEQASLPCHFNPSVNLFSSLREEEIDDIGYALYSGLQEPEGLL 410 420 430 440 450 460 >>CCDS45625.1 MIEF2 gene_id:125170|Hs108|chr17 (205 aa) initn: 273 init1: 217 opt: 263 Z-score: 313.1 bits: 66.1 E(32554): 4e-11 Smith-Waterman score: 263; 46.7% identity (72.4% similar) in 105 aa overlap (1-103:1-101) 10 20 30 40 50 pF1KB8 MAGAGERKGKK-DDNGIGTAIDFVLSNARLVLGVGGAAMLGIATLAVKRMYDRAISAPTS :: ....::. .:.:.:. .::.:.::::::::::::.::::::::::. ::: :: CCDS45 MAEFSQKRGKRRSDEGLGSMVDFLLANARLVLGVGGAAVLGIATLAVKRFIDRA----TS 10 20 30 40 50 60 70 80 90 100 110 pF1KB8 PTRLSHSGKRSWEEPNWM-GSPRLLNRDMKTGLSRSLQTLPTDSSTFDTDTFCPPRPKPV : . . ::.: . . ..:.: : ..::. . : .:: CCDS45 PRDEDDTKADSWKELSLLKATPHLQPRPPPAALSQPVLPLAPSSSAPGEAAGLRAGPCDH 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB8 ARKGQVDLKKSRLRMSLQEKLLTYYRNRAAIPAGEQARAKQAAVDICAELRSFLRAKLPD CCDS45 PSSPGGFGQTAGWRHRPGAAGLLSEQVPGTALWGIRAWGAALRRAAGGGCGPCASPGATG 120 130 140 150 160 170 478 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 11:32:02 2016 done: Fri Nov 4 11:32:03 2016 Total Scan time: 3.090 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]