Result of FASTA (omim) for
pF1KB8303
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB8303, 600 aa
1>>>pF1KB8303 600 - 600 aa - 600 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.4346+/-0.000429; mu= 18.5895+/- 0.027
mean_var=71.4278+/-14.698, 0's: 0 Z-trim(109.9): 31 B-trim: 0 in 0/55
Lambda= 0.151754
statistics sampled from 18180 (18208) to 18180 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.574), E-opt: 0.2 (0.213), width: 16
Scan time: 8.630
The best scores are: opt bits E(85289)
NP_060341 (OMIM: 611354) integrator complex subuni ( 600) 4015 888.9 0
NP_001243385 (OMIM: 611354) integrator complex sub ( 606) 3955 875.7 0
XP_011539950 (OMIM: 611354) PREDICTED: integrator ( 622) 3955 875.7 0
XP_011539949 (OMIM: 611354) PREDICTED: integrator ( 660) 3955 875.7 0
NP_001243389 (OMIM: 611354) integrator complex sub ( 571) 3825 847.3 0
XP_011539952 (OMIM: 611354) PREDICTED: integrator ( 476) 3153 700.1 4.4e-201
XP_016857046 (OMIM: 611354) PREDICTED: integrator ( 476) 3153 700.1 4.4e-201
XP_016857047 (OMIM: 611354) PREDICTED: integrator ( 476) 3153 700.1 4.4e-201
NP_001243392 (OMIM: 611354) integrator complex sub ( 499) 3032 673.6 4.3e-193
NP_001243391 (OMIM: 611354) integrator complex sub ( 502) 3020 671.0 2.7e-192
NP_057291 (OMIM: 606029) cleavage and polyadenylat ( 684) 1147 261.0 9.5e-69
NP_001308765 (OMIM: 606029) cleavage and polyadeny ( 688) 1128 256.8 1.7e-67
NP_001308763 (OMIM: 606029) cleavage and polyadeny ( 647) 1039 237.3 1.2e-61
NP_001308762 (OMIM: 606029) cleavage and polyadeny ( 647) 1039 237.3 1.2e-61
NP_001308764 (OMIM: 606029) cleavage and polyadeny ( 545) 781 180.8 1e-44
NP_001309199 (OMIM: 606028) cleavage and polyadeny ( 731) 438 105.8 5.4e-22
NP_059133 (OMIM: 606028) cleavage and polyadenylat ( 782) 438 105.8 5.7e-22
NP_001309201 (OMIM: 606028) cleavage and polyadeny ( 782) 438 105.8 5.7e-22
NP_001309200 (OMIM: 606028) cleavage and polyadeny ( 629) 307 77.1 2e-13
XP_006716420 (OMIM: 611352) PREDICTED: integrator ( 646) 159 44.7 0.0012
XP_011542877 (OMIM: 611352) PREDICTED: integrator ( 652) 159 44.7 0.0012
XP_011542876 (OMIM: 611352) PREDICTED: integrator ( 652) 159 44.7 0.0012
XP_011542875 (OMIM: 611352) PREDICTED: integrator ( 655) 159 44.7 0.0012
NP_060720 (OMIM: 611352) integrator complex subuni ( 658) 159 44.7 0.0012
XP_006716419 (OMIM: 611352) PREDICTED: integrator ( 676) 159 44.7 0.0012
>>NP_060341 (OMIM: 611354) integrator complex subunit 11 (600 aa)
initn: 4015 init1: 4015 opt: 4015 Z-score: 4749.5 bits: 888.9 E(85289): 0
Smith-Waterman score: 4015; 99.8% identity (99.8% similar) in 600 aa overlap (1-600:1-600)
10 20 30 40 50 60
pF1KB8 MPEIRVTPLGAGQDVGRSCILVSIAGKNVMLDCGMHMGFNDDRRFPDFSYITQNGRLTDF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 MPEIRVTPLGAGQDVGRSCILVSIAGKNVMLDCGMHMGFNDDRRFPDFSYITQNGRLTDF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 LDCVIISHFHLDHCGALPYFSEMVGYDGPIYMTHSTQAICPILLEDYRKIAVDKKGEANF
:::::::::::::::::::::::::::::::::: :::::::::::::::::::::::::
NP_060 LDCVIISHFHLDHCGALPYFSEMVGYDGPIYMTHPTQAICPILLEDYRKIAVDKKGEANF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 FTSQMIKDCMKKVVAVHLHQTVQVDDELEIKAYYAGHVLGAAMFQIKVGSESVVYTGDYN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 FTSQMIKDCMKKVVAVHLHQTVQVDDELEIKAYYAGHVLGAAMFQIKVGSESVVYTGDYN
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB8 MTPDRHLGAAWIDKCRPNLLITESTYATTIRDSKRCRERDFLKKVHETVERGGKVLIPVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 MTPDRHLGAAWIDKCRPNLLITESTYATTIRDSKRCRERDFLKKVHETVERGGKVLIPVF
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB8 ALGRAQELCILLETFWERMNLKVPIYFSTGLTEKANHYYKLFIPWTNQKIRKTFVQRNMF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 ALGRAQELCILLETFWERMNLKVPIYFSTGLTEKANHYYKLFIPWTNQKIRKTFVQRNMF
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB8 EFKHIKAFDRAFADNPGPMVVFATPGMLHAGQSLQIFRKWAGNEKNMVIMPGYCVQGTVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 EFKHIKAFDRAFADNPGPMVVFATPGMLHAGQSLQIFRKWAGNEKNMVIMPGYCVQGTVG
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB8 HKILSGQRKLEMEGRQVLEVKMQVEYMSFSAHADAKGIMQLVGQAEPESVLLVHGEAKKM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 HKILSGQRKLEMEGRQVLEVKMQVEYMSFSAHADAKGIMQLVGQAEPESVLLVHGEAKKM
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB8 EFLKQKIEQELRVNCYMPANGETVTLPTSPSIPVGISLGLLKREMAQGLLPEAKKPRLLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 EFLKQKIEQELRVNCYMPANGETVTLPTSPSIPVGISLGLLKREMAQGLLPEAKKPRLLH
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB8 GTLIMKDSNFRLVSSEQALKELGLAEHQLRFTCRVHLHDTRKEQETALRVYSHLKSVLKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 GTLIMKDSNFRLVSSEQALKELGLAEHQLRFTCRVHLHDTRKEQETALRVYSHLKSVLKD
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB8 HCVQHLPDGSVTVESVLLQAAAPSEDPGTKVLLVSWTYQDEELGSFLTSLLKKGLPQAPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 HCVQHLPDGSVTVESVLLQAAAPSEDPGTKVLLVSWTYQDEELGSFLTSLLKKGLPQAPS
550 560 570 580 590 600
>>NP_001243385 (OMIM: 611354) integrator complex subunit (606 aa)
initn: 3955 init1: 3955 opt: 3955 Z-score: 4678.5 bits: 875.7 E(85289): 0
Smith-Waterman score: 3955; 99.8% identity (99.8% similar) in 591 aa overlap (10-600:16-606)
10 20 30 40 50
pF1KB8 MPEIRVTPLGAGQDVGRSCILVSIAGKNVMLDCGMHMGFNDDRRFPDFSYITQN
:::::::::::::::::::::::::::::::::::::::::::::
NP_001 MCGAGFGHFEWLAGGGAGQDVGRSCILVSIAGKNVMLDCGMHMGFNDDRRFPDFSYITQN
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB8 GRLTDFLDCVIISHFHLDHCGALPYFSEMVGYDGPIYMTHSTQAICPILLEDYRKIAVDK
:::::::::::::::::::::::::::::::::::::::: :::::::::::::::::::
NP_001 GRLTDFLDCVIISHFHLDHCGALPYFSEMVGYDGPIYMTHPTQAICPILLEDYRKIAVDK
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB8 KGEANFFTSQMIKDCMKKVVAVHLHQTVQVDDELEIKAYYAGHVLGAAMFQIKVGSESVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KGEANFFTSQMIKDCMKKVVAVHLHQTVQVDDELEIKAYYAGHVLGAAMFQIKVGSESVV
130 140 150 160 170 180
180 190 200 210 220 230
pF1KB8 YTGDYNMTPDRHLGAAWIDKCRPNLLITESTYATTIRDSKRCRERDFLKKVHETVERGGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YTGDYNMTPDRHLGAAWIDKCRPNLLITESTYATTIRDSKRCRERDFLKKVHETVERGGK
190 200 210 220 230 240
240 250 260 270 280 290
pF1KB8 VLIPVFALGRAQELCILLETFWERMNLKVPIYFSTGLTEKANHYYKLFIPWTNQKIRKTF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VLIPVFALGRAQELCILLETFWERMNLKVPIYFSTGLTEKANHYYKLFIPWTNQKIRKTF
250 260 270 280 290 300
300 310 320 330 340 350
pF1KB8 VQRNMFEFKHIKAFDRAFADNPGPMVVFATPGMLHAGQSLQIFRKWAGNEKNMVIMPGYC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VQRNMFEFKHIKAFDRAFADNPGPMVVFATPGMLHAGQSLQIFRKWAGNEKNMVIMPGYC
310 320 330 340 350 360
360 370 380 390 400 410
pF1KB8 VQGTVGHKILSGQRKLEMEGRQVLEVKMQVEYMSFSAHADAKGIMQLVGQAEPESVLLVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VQGTVGHKILSGQRKLEMEGRQVLEVKMQVEYMSFSAHADAKGIMQLVGQAEPESVLLVH
370 380 390 400 410 420
420 430 440 450 460 470
pF1KB8 GEAKKMEFLKQKIEQELRVNCYMPANGETVTLPTSPSIPVGISLGLLKREMAQGLLPEAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GEAKKMEFLKQKIEQELRVNCYMPANGETVTLPTSPSIPVGISLGLLKREMAQGLLPEAK
430 440 450 460 470 480
480 490 500 510 520 530
pF1KB8 KPRLLHGTLIMKDSNFRLVSSEQALKELGLAEHQLRFTCRVHLHDTRKEQETALRVYSHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KPRLLHGTLIMKDSNFRLVSSEQALKELGLAEHQLRFTCRVHLHDTRKEQETALRVYSHL
490 500 510 520 530 540
540 550 560 570 580 590
pF1KB8 KSVLKDHCVQHLPDGSVTVESVLLQAAAPSEDPGTKVLLVSWTYQDEELGSFLTSLLKKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KSVLKDHCVQHLPDGSVTVESVLLQAAAPSEDPGTKVLLVSWTYQDEELGSFLTSLLKKG
550 560 570 580 590 600
600
pF1KB8 LPQAPS
::::::
NP_001 LPQAPS
>>XP_011539950 (OMIM: 611354) PREDICTED: integrator comp (622 aa)
initn: 3955 init1: 3955 opt: 3955 Z-score: 4678.3 bits: 875.7 E(85289): 0
Smith-Waterman score: 3955; 99.8% identity (99.8% similar) in 591 aa overlap (10-600:32-622)
10 20 30
pF1KB8 MPEIRVTPLGAGQDVGRSCILVSIAGKNVMLDCGMHMGF
::::::::::::::::::::::::::::::
XP_011 SSPMAQPLGCGPVILMCGAGFGHFEWLAGGGAGQDVGRSCILVSIAGKNVMLDCGMHMGF
10 20 30 40 50 60
40 50 60 70 80 90
pF1KB8 NDDRRFPDFSYITQNGRLTDFLDCVIISHFHLDHCGALPYFSEMVGYDGPIYMTHSTQAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::: ::::
XP_011 NDDRRFPDFSYITQNGRLTDFLDCVIISHFHLDHCGALPYFSEMVGYDGPIYMTHPTQAI
70 80 90 100 110 120
100 110 120 130 140 150
pF1KB8 CPILLEDYRKIAVDKKGEANFFTSQMIKDCMKKVVAVHLHQTVQVDDELEIKAYYAGHVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CPILLEDYRKIAVDKKGEANFFTSQMIKDCMKKVVAVHLHQTVQVDDELEIKAYYAGHVL
130 140 150 160 170 180
160 170 180 190 200 210
pF1KB8 GAAMFQIKVGSESVVYTGDYNMTPDRHLGAAWIDKCRPNLLITESTYATTIRDSKRCRER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GAAMFQIKVGSESVVYTGDYNMTPDRHLGAAWIDKCRPNLLITESTYATTIRDSKRCRER
190 200 210 220 230 240
220 230 240 250 260 270
pF1KB8 DFLKKVHETVERGGKVLIPVFALGRAQELCILLETFWERMNLKVPIYFSTGLTEKANHYY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DFLKKVHETVERGGKVLIPVFALGRAQELCILLETFWERMNLKVPIYFSTGLTEKANHYY
250 260 270 280 290 300
280 290 300 310 320 330
pF1KB8 KLFIPWTNQKIRKTFVQRNMFEFKHIKAFDRAFADNPGPMVVFATPGMLHAGQSLQIFRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KLFIPWTNQKIRKTFVQRNMFEFKHIKAFDRAFADNPGPMVVFATPGMLHAGQSLQIFRK
310 320 330 340 350 360
340 350 360 370 380 390
pF1KB8 WAGNEKNMVIMPGYCVQGTVGHKILSGQRKLEMEGRQVLEVKMQVEYMSFSAHADAKGIM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WAGNEKNMVIMPGYCVQGTVGHKILSGQRKLEMEGRQVLEVKMQVEYMSFSAHADAKGIM
370 380 390 400 410 420
400 410 420 430 440 450
pF1KB8 QLVGQAEPESVLLVHGEAKKMEFLKQKIEQELRVNCYMPANGETVTLPTSPSIPVGISLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QLVGQAEPESVLLVHGEAKKMEFLKQKIEQELRVNCYMPANGETVTLPTSPSIPVGISLG
430 440 450 460 470 480
460 470 480 490 500 510
pF1KB8 LLKREMAQGLLPEAKKPRLLHGTLIMKDSNFRLVSSEQALKELGLAEHQLRFTCRVHLHD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLKREMAQGLLPEAKKPRLLHGTLIMKDSNFRLVSSEQALKELGLAEHQLRFTCRVHLHD
490 500 510 520 530 540
520 530 540 550 560 570
pF1KB8 TRKEQETALRVYSHLKSVLKDHCVQHLPDGSVTVESVLLQAAAPSEDPGTKVLLVSWTYQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TRKEQETALRVYSHLKSVLKDHCVQHLPDGSVTVESVLLQAAAPSEDPGTKVLLVSWTYQ
550 560 570 580 590 600
580 590 600
pF1KB8 DEELGSFLTSLLKKGLPQAPS
:::::::::::::::::::::
XP_011 DEELGSFLTSLLKKGLPQAPS
610 620
>>XP_011539949 (OMIM: 611354) PREDICTED: integrator comp (660 aa)
initn: 3955 init1: 3955 opt: 3955 Z-score: 4677.9 bits: 875.7 E(85289): 0
Smith-Waterman score: 3955; 99.8% identity (99.8% similar) in 591 aa overlap (10-600:70-660)
10 20 30
pF1KB8 MPEIRVTPLGAGQDVGRSCILVSIAGKNVMLDCGMHMGF
::::::::::::::::::::::::::::::
XP_011 HVLPHGPLGCGPVILMCGAGFGHFEWLAGGGAGQDVGRSCILVSIAGKNVMLDCGMHMGF
40 50 60 70 80 90
40 50 60 70 80 90
pF1KB8 NDDRRFPDFSYITQNGRLTDFLDCVIISHFHLDHCGALPYFSEMVGYDGPIYMTHSTQAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::: ::::
XP_011 NDDRRFPDFSYITQNGRLTDFLDCVIISHFHLDHCGALPYFSEMVGYDGPIYMTHPTQAI
100 110 120 130 140 150
100 110 120 130 140 150
pF1KB8 CPILLEDYRKIAVDKKGEANFFTSQMIKDCMKKVVAVHLHQTVQVDDELEIKAYYAGHVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CPILLEDYRKIAVDKKGEANFFTSQMIKDCMKKVVAVHLHQTVQVDDELEIKAYYAGHVL
160 170 180 190 200 210
160 170 180 190 200 210
pF1KB8 GAAMFQIKVGSESVVYTGDYNMTPDRHLGAAWIDKCRPNLLITESTYATTIRDSKRCRER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GAAMFQIKVGSESVVYTGDYNMTPDRHLGAAWIDKCRPNLLITESTYATTIRDSKRCRER
220 230 240 250 260 270
220 230 240 250 260 270
pF1KB8 DFLKKVHETVERGGKVLIPVFALGRAQELCILLETFWERMNLKVPIYFSTGLTEKANHYY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DFLKKVHETVERGGKVLIPVFALGRAQELCILLETFWERMNLKVPIYFSTGLTEKANHYY
280 290 300 310 320 330
280 290 300 310 320 330
pF1KB8 KLFIPWTNQKIRKTFVQRNMFEFKHIKAFDRAFADNPGPMVVFATPGMLHAGQSLQIFRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KLFIPWTNQKIRKTFVQRNMFEFKHIKAFDRAFADNPGPMVVFATPGMLHAGQSLQIFRK
340 350 360 370 380 390
340 350 360 370 380 390
pF1KB8 WAGNEKNMVIMPGYCVQGTVGHKILSGQRKLEMEGRQVLEVKMQVEYMSFSAHADAKGIM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WAGNEKNMVIMPGYCVQGTVGHKILSGQRKLEMEGRQVLEVKMQVEYMSFSAHADAKGIM
400 410 420 430 440 450
400 410 420 430 440 450
pF1KB8 QLVGQAEPESVLLVHGEAKKMEFLKQKIEQELRVNCYMPANGETVTLPTSPSIPVGISLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QLVGQAEPESVLLVHGEAKKMEFLKQKIEQELRVNCYMPANGETVTLPTSPSIPVGISLG
460 470 480 490 500 510
460 470 480 490 500 510
pF1KB8 LLKREMAQGLLPEAKKPRLLHGTLIMKDSNFRLVSSEQALKELGLAEHQLRFTCRVHLHD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLKREMAQGLLPEAKKPRLLHGTLIMKDSNFRLVSSEQALKELGLAEHQLRFTCRVHLHD
520 530 540 550 560 570
520 530 540 550 560 570
pF1KB8 TRKEQETALRVYSHLKSVLKDHCVQHLPDGSVTVESVLLQAAAPSEDPGTKVLLVSWTYQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TRKEQETALRVYSHLKSVLKDHCVQHLPDGSVTVESVLLQAAAPSEDPGTKVLLVSWTYQ
580 590 600 610 620 630
580 590 600
pF1KB8 DEELGSFLTSLLKKGLPQAPS
:::::::::::::::::::::
XP_011 DEELGSFLTSLLKKGLPQAPS
640 650 660
>>NP_001243389 (OMIM: 611354) integrator complex subunit (571 aa)
initn: 3825 init1: 3825 opt: 3825 Z-score: 4525.1 bits: 847.3 E(85289): 0
Smith-Waterman score: 3825; 99.8% identity (99.8% similar) in 571 aa overlap (30-600:1-571)
10 20 30 40 50 60
pF1KB8 MPEIRVTPLGAGQDVGRSCILVSIAGKNVMLDCGMHMGFNDDRRFPDFSYITQNGRLTDF
:::::::::::::::::::::::::::::::
NP_001 MLDCGMHMGFNDDRRFPDFSYITQNGRLTDF
10 20 30
70 80 90 100 110 120
pF1KB8 LDCVIISHFHLDHCGALPYFSEMVGYDGPIYMTHSTQAICPILLEDYRKIAVDKKGEANF
:::::::::::::::::::::::::::::::::: :::::::::::::::::::::::::
NP_001 LDCVIISHFHLDHCGALPYFSEMVGYDGPIYMTHPTQAICPILLEDYRKIAVDKKGEANF
40 50 60 70 80 90
130 140 150 160 170 180
pF1KB8 FTSQMIKDCMKKVVAVHLHQTVQVDDELEIKAYYAGHVLGAAMFQIKVGSESVVYTGDYN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FTSQMIKDCMKKVVAVHLHQTVQVDDELEIKAYYAGHVLGAAMFQIKVGSESVVYTGDYN
100 110 120 130 140 150
190 200 210 220 230 240
pF1KB8 MTPDRHLGAAWIDKCRPNLLITESTYATTIRDSKRCRERDFLKKVHETVERGGKVLIPVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MTPDRHLGAAWIDKCRPNLLITESTYATTIRDSKRCRERDFLKKVHETVERGGKVLIPVF
160 170 180 190 200 210
250 260 270 280 290 300
pF1KB8 ALGRAQELCILLETFWERMNLKVPIYFSTGLTEKANHYYKLFIPWTNQKIRKTFVQRNMF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ALGRAQELCILLETFWERMNLKVPIYFSTGLTEKANHYYKLFIPWTNQKIRKTFVQRNMF
220 230 240 250 260 270
310 320 330 340 350 360
pF1KB8 EFKHIKAFDRAFADNPGPMVVFATPGMLHAGQSLQIFRKWAGNEKNMVIMPGYCVQGTVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EFKHIKAFDRAFADNPGPMVVFATPGMLHAGQSLQIFRKWAGNEKNMVIMPGYCVQGTVG
280 290 300 310 320 330
370 380 390 400 410 420
pF1KB8 HKILSGQRKLEMEGRQVLEVKMQVEYMSFSAHADAKGIMQLVGQAEPESVLLVHGEAKKM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HKILSGQRKLEMEGRQVLEVKMQVEYMSFSAHADAKGIMQLVGQAEPESVLLVHGEAKKM
340 350 360 370 380 390
430 440 450 460 470 480
pF1KB8 EFLKQKIEQELRVNCYMPANGETVTLPTSPSIPVGISLGLLKREMAQGLLPEAKKPRLLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EFLKQKIEQELRVNCYMPANGETVTLPTSPSIPVGISLGLLKREMAQGLLPEAKKPRLLH
400 410 420 430 440 450
490 500 510 520 530 540
pF1KB8 GTLIMKDSNFRLVSSEQALKELGLAEHQLRFTCRVHLHDTRKEQETALRVYSHLKSVLKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GTLIMKDSNFRLVSSEQALKELGLAEHQLRFTCRVHLHDTRKEQETALRVYSHLKSVLKD
460 470 480 490 500 510
550 560 570 580 590 600
pF1KB8 HCVQHLPDGSVTVESVLLQAAAPSEDPGTKVLLVSWTYQDEELGSFLTSLLKKGLPQAPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HCVQHLPDGSVTVESVLLQAAAPSEDPGTKVLLVSWTYQDEELGSFLTSLLKKGLPQAPS
520 530 540 550 560 570
>>XP_011539952 (OMIM: 611354) PREDICTED: integrator comp (476 aa)
initn: 3153 init1: 3153 opt: 3153 Z-score: 3731.1 bits: 700.1 E(85289): 4.4e-201
Smith-Waterman score: 3153; 100.0% identity (100.0% similar) in 476 aa overlap (125-600:1-476)
100 110 120 130 140 150
pF1KB8 STQAICPILLEDYRKIAVDKKGEANFFTSQMIKDCMKKVVAVHLHQTVQVDDELEIKAYY
::::::::::::::::::::::::::::::
XP_011 MIKDCMKKVVAVHLHQTVQVDDELEIKAYY
10 20 30
160 170 180 190 200 210
pF1KB8 AGHVLGAAMFQIKVGSESVVYTGDYNMTPDRHLGAAWIDKCRPNLLITESTYATTIRDSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AGHVLGAAMFQIKVGSESVVYTGDYNMTPDRHLGAAWIDKCRPNLLITESTYATTIRDSK
40 50 60 70 80 90
220 230 240 250 260 270
pF1KB8 RCRERDFLKKVHETVERGGKVLIPVFALGRAQELCILLETFWERMNLKVPIYFSTGLTEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RCRERDFLKKVHETVERGGKVLIPVFALGRAQELCILLETFWERMNLKVPIYFSTGLTEK
100 110 120 130 140 150
280 290 300 310 320 330
pF1KB8 ANHYYKLFIPWTNQKIRKTFVQRNMFEFKHIKAFDRAFADNPGPMVVFATPGMLHAGQSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ANHYYKLFIPWTNQKIRKTFVQRNMFEFKHIKAFDRAFADNPGPMVVFATPGMLHAGQSL
160 170 180 190 200 210
340 350 360 370 380 390
pF1KB8 QIFRKWAGNEKNMVIMPGYCVQGTVGHKILSGQRKLEMEGRQVLEVKMQVEYMSFSAHAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QIFRKWAGNEKNMVIMPGYCVQGTVGHKILSGQRKLEMEGRQVLEVKMQVEYMSFSAHAD
220 230 240 250 260 270
400 410 420 430 440 450
pF1KB8 AKGIMQLVGQAEPESVLLVHGEAKKMEFLKQKIEQELRVNCYMPANGETVTLPTSPSIPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AKGIMQLVGQAEPESVLLVHGEAKKMEFLKQKIEQELRVNCYMPANGETVTLPTSPSIPV
280 290 300 310 320 330
460 470 480 490 500 510
pF1KB8 GISLGLLKREMAQGLLPEAKKPRLLHGTLIMKDSNFRLVSSEQALKELGLAEHQLRFTCR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GISLGLLKREMAQGLLPEAKKPRLLHGTLIMKDSNFRLVSSEQALKELGLAEHQLRFTCR
340 350 360 370 380 390
520 530 540 550 560 570
pF1KB8 VHLHDTRKEQETALRVYSHLKSVLKDHCVQHLPDGSVTVESVLLQAAAPSEDPGTKVLLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VHLHDTRKEQETALRVYSHLKSVLKDHCVQHLPDGSVTVESVLLQAAAPSEDPGTKVLLV
400 410 420 430 440 450
580 590 600
pF1KB8 SWTYQDEELGSFLTSLLKKGLPQAPS
::::::::::::::::::::::::::
XP_011 SWTYQDEELGSFLTSLLKKGLPQAPS
460 470
>>XP_016857046 (OMIM: 611354) PREDICTED: integrator comp (476 aa)
initn: 3153 init1: 3153 opt: 3153 Z-score: 3731.1 bits: 700.1 E(85289): 4.4e-201
Smith-Waterman score: 3153; 100.0% identity (100.0% similar) in 476 aa overlap (125-600:1-476)
100 110 120 130 140 150
pF1KB8 STQAICPILLEDYRKIAVDKKGEANFFTSQMIKDCMKKVVAVHLHQTVQVDDELEIKAYY
::::::::::::::::::::::::::::::
XP_016 MIKDCMKKVVAVHLHQTVQVDDELEIKAYY
10 20 30
160 170 180 190 200 210
pF1KB8 AGHVLGAAMFQIKVGSESVVYTGDYNMTPDRHLGAAWIDKCRPNLLITESTYATTIRDSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AGHVLGAAMFQIKVGSESVVYTGDYNMTPDRHLGAAWIDKCRPNLLITESTYATTIRDSK
40 50 60 70 80 90
220 230 240 250 260 270
pF1KB8 RCRERDFLKKVHETVERGGKVLIPVFALGRAQELCILLETFWERMNLKVPIYFSTGLTEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RCRERDFLKKVHETVERGGKVLIPVFALGRAQELCILLETFWERMNLKVPIYFSTGLTEK
100 110 120 130 140 150
280 290 300 310 320 330
pF1KB8 ANHYYKLFIPWTNQKIRKTFVQRNMFEFKHIKAFDRAFADNPGPMVVFATPGMLHAGQSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ANHYYKLFIPWTNQKIRKTFVQRNMFEFKHIKAFDRAFADNPGPMVVFATPGMLHAGQSL
160 170 180 190 200 210
340 350 360 370 380 390
pF1KB8 QIFRKWAGNEKNMVIMPGYCVQGTVGHKILSGQRKLEMEGRQVLEVKMQVEYMSFSAHAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QIFRKWAGNEKNMVIMPGYCVQGTVGHKILSGQRKLEMEGRQVLEVKMQVEYMSFSAHAD
220 230 240 250 260 270
400 410 420 430 440 450
pF1KB8 AKGIMQLVGQAEPESVLLVHGEAKKMEFLKQKIEQELRVNCYMPANGETVTLPTSPSIPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AKGIMQLVGQAEPESVLLVHGEAKKMEFLKQKIEQELRVNCYMPANGETVTLPTSPSIPV
280 290 300 310 320 330
460 470 480 490 500 510
pF1KB8 GISLGLLKREMAQGLLPEAKKPRLLHGTLIMKDSNFRLVSSEQALKELGLAEHQLRFTCR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GISLGLLKREMAQGLLPEAKKPRLLHGTLIMKDSNFRLVSSEQALKELGLAEHQLRFTCR
340 350 360 370 380 390
520 530 540 550 560 570
pF1KB8 VHLHDTRKEQETALRVYSHLKSVLKDHCVQHLPDGSVTVESVLLQAAAPSEDPGTKVLLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VHLHDTRKEQETALRVYSHLKSVLKDHCVQHLPDGSVTVESVLLQAAAPSEDPGTKVLLV
400 410 420 430 440 450
580 590 600
pF1KB8 SWTYQDEELGSFLTSLLKKGLPQAPS
::::::::::::::::::::::::::
XP_016 SWTYQDEELGSFLTSLLKKGLPQAPS
460 470
>>XP_016857047 (OMIM: 611354) PREDICTED: integrator comp (476 aa)
initn: 3153 init1: 3153 opt: 3153 Z-score: 3731.1 bits: 700.1 E(85289): 4.4e-201
Smith-Waterman score: 3153; 100.0% identity (100.0% similar) in 476 aa overlap (125-600:1-476)
100 110 120 130 140 150
pF1KB8 STQAICPILLEDYRKIAVDKKGEANFFTSQMIKDCMKKVVAVHLHQTVQVDDELEIKAYY
::::::::::::::::::::::::::::::
XP_016 MIKDCMKKVVAVHLHQTVQVDDELEIKAYY
10 20 30
160 170 180 190 200 210
pF1KB8 AGHVLGAAMFQIKVGSESVVYTGDYNMTPDRHLGAAWIDKCRPNLLITESTYATTIRDSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AGHVLGAAMFQIKVGSESVVYTGDYNMTPDRHLGAAWIDKCRPNLLITESTYATTIRDSK
40 50 60 70 80 90
220 230 240 250 260 270
pF1KB8 RCRERDFLKKVHETVERGGKVLIPVFALGRAQELCILLETFWERMNLKVPIYFSTGLTEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RCRERDFLKKVHETVERGGKVLIPVFALGRAQELCILLETFWERMNLKVPIYFSTGLTEK
100 110 120 130 140 150
280 290 300 310 320 330
pF1KB8 ANHYYKLFIPWTNQKIRKTFVQRNMFEFKHIKAFDRAFADNPGPMVVFATPGMLHAGQSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ANHYYKLFIPWTNQKIRKTFVQRNMFEFKHIKAFDRAFADNPGPMVVFATPGMLHAGQSL
160 170 180 190 200 210
340 350 360 370 380 390
pF1KB8 QIFRKWAGNEKNMVIMPGYCVQGTVGHKILSGQRKLEMEGRQVLEVKMQVEYMSFSAHAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QIFRKWAGNEKNMVIMPGYCVQGTVGHKILSGQRKLEMEGRQVLEVKMQVEYMSFSAHAD
220 230 240 250 260 270
400 410 420 430 440 450
pF1KB8 AKGIMQLVGQAEPESVLLVHGEAKKMEFLKQKIEQELRVNCYMPANGETVTLPTSPSIPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AKGIMQLVGQAEPESVLLVHGEAKKMEFLKQKIEQELRVNCYMPANGETVTLPTSPSIPV
280 290 300 310 320 330
460 470 480 490 500 510
pF1KB8 GISLGLLKREMAQGLLPEAKKPRLLHGTLIMKDSNFRLVSSEQALKELGLAEHQLRFTCR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GISLGLLKREMAQGLLPEAKKPRLLHGTLIMKDSNFRLVSSEQALKELGLAEHQLRFTCR
340 350 360 370 380 390
520 530 540 550 560 570
pF1KB8 VHLHDTRKEQETALRVYSHLKSVLKDHCVQHLPDGSVTVESVLLQAAAPSEDPGTKVLLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VHLHDTRKEQETALRVYSHLKSVLKDHCVQHLPDGSVTVESVLLQAAAPSEDPGTKVLLV
400 410 420 430 440 450
580 590 600
pF1KB8 SWTYQDEELGSFLTSLLKKGLPQAPS
::::::::::::::::::::::::::
XP_016 SWTYQDEELGSFLTSLLKKGLPQAPS
460 470
>>NP_001243392 (OMIM: 611354) integrator complex subunit (499 aa)
initn: 3306 init1: 3026 opt: 3032 Z-score: 3587.6 bits: 673.6 E(85289): 4.3e-193
Smith-Waterman score: 3108; 83.2% identity (83.2% similar) in 600 aa overlap (1-600:1-499)
10 20 30 40 50 60
pF1KB8 MPEIRVTPLGAGQDVGRSCILVSIAGKNVMLDCGMHMGFNDDRRFPDFSYITQNGRLTDF
::::::::::::::::::::::::::::::::::::::::::
NP_001 MPEIRVTPLGAGQDVGRSCILVSIAGKNVMLDCGMHMGFNDD------------------
10 20 30 40
70 80 90 100 110 120
pF1KB8 LDCVIISHFHLDHCGALPYFSEMVGYDGPIYMTHSTQAICPILLEDYRKIAVDKKGEANF
NP_001 ------------------------------------------------------------
130 140 150 160 170 180
pF1KB8 FTSQMIKDCMKKVVAVHLHQTVQVDDELEIKAYYAGHVLGAAMFQIKVGSESVVYTGDYN
:::::::::::::::::::::::::::::::::::::
NP_001 -----------------------VDDELEIKAYYAGHVLGAAMFQIKVGSESVVYTGDYN
50 60 70
190 200 210 220 230 240
pF1KB8 MTPDRHLGAAWIDKCRPNLLITESTYATTIRDSKRCRERDFLKKVHETVERGGKVLIPVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MTPDRHLGAAWIDKCRPNLLITESTYATTIRDSKRCRERDFLKKVHETVERGGKVLIPVF
80 90 100 110 120 130
250 260 270 280 290 300
pF1KB8 ALGRAQELCILLETFWERMNLKVPIYFSTGLTEKANHYYKLFIPWTNQKIRKTFVQRNMF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ALGRAQELCILLETFWERMNLKVPIYFSTGLTEKANHYYKLFIPWTNQKIRKTFVQRNMF
140 150 160 170 180 190
310 320 330 340 350 360
pF1KB8 EFKHIKAFDRAFADNPGPMVVFATPGMLHAGQSLQIFRKWAGNEKNMVIMPGYCVQGTVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EFKHIKAFDRAFADNPGPMVVFATPGMLHAGQSLQIFRKWAGNEKNMVIMPGYCVQGTVG
200 210 220 230 240 250
370 380 390 400 410 420
pF1KB8 HKILSGQRKLEMEGRQVLEVKMQVEYMSFSAHADAKGIMQLVGQAEPESVLLVHGEAKKM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HKILSGQRKLEMEGRQVLEVKMQVEYMSFSAHADAKGIMQLVGQAEPESVLLVHGEAKKM
260 270 280 290 300 310
430 440 450 460 470 480
pF1KB8 EFLKQKIEQELRVNCYMPANGETVTLPTSPSIPVGISLGLLKREMAQGLLPEAKKPRLLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EFLKQKIEQELRVNCYMPANGETVTLPTSPSIPVGISLGLLKREMAQGLLPEAKKPRLLH
320 330 340 350 360 370
490 500 510 520 530 540
pF1KB8 GTLIMKDSNFRLVSSEQALKELGLAEHQLRFTCRVHLHDTRKEQETALRVYSHLKSVLKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GTLIMKDSNFRLVSSEQALKELGLAEHQLRFTCRVHLHDTRKEQETALRVYSHLKSVLKD
380 390 400 410 420 430
550 560 570 580 590 600
pF1KB8 HCVQHLPDGSVTVESVLLQAAAPSEDPGTKVLLVSWTYQDEELGSFLTSLLKKGLPQAPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HCVQHLPDGSVTVESVLLQAAAPSEDPGTKVLLVSWTYQDEELGSFLTSLLKKGLPQAPS
440 450 460 470 480 490
>>NP_001243391 (OMIM: 611354) integrator complex subunit (502 aa)
initn: 3081 init1: 3020 opt: 3020 Z-score: 3573.4 bits: 671.0 E(85289): 2.7e-192
Smith-Waterman score: 3020; 99.8% identity (100.0% similar) in 457 aa overlap (144-600:46-502)
120 130 140 150 160 170
pF1KB8 KKGEANFFTSQMIKDCMKKVVAVHLHQTVQVDDELEIKAYYAGHVLGAAMFQIKVGSESV
:.::::::::::::::::::::::::::::
NP_001 SWNLVLPPGRGSRAPSSTDTRTGFHVLPHGVNDELEIKAYYAGHVLGAAMFQIKVGSESV
20 30 40 50 60 70
180 190 200 210 220 230
pF1KB8 VYTGDYNMTPDRHLGAAWIDKCRPNLLITESTYATTIRDSKRCRERDFLKKVHETVERGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VYTGDYNMTPDRHLGAAWIDKCRPNLLITESTYATTIRDSKRCRERDFLKKVHETVERGG
80 90 100 110 120 130
240 250 260 270 280 290
pF1KB8 KVLIPVFALGRAQELCILLETFWERMNLKVPIYFSTGLTEKANHYYKLFIPWTNQKIRKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KVLIPVFALGRAQELCILLETFWERMNLKVPIYFSTGLTEKANHYYKLFIPWTNQKIRKT
140 150 160 170 180 190
300 310 320 330 340 350
pF1KB8 FVQRNMFEFKHIKAFDRAFADNPGPMVVFATPGMLHAGQSLQIFRKWAGNEKNMVIMPGY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FVQRNMFEFKHIKAFDRAFADNPGPMVVFATPGMLHAGQSLQIFRKWAGNEKNMVIMPGY
200 210 220 230 240 250
360 370 380 390 400 410
pF1KB8 CVQGTVGHKILSGQRKLEMEGRQVLEVKMQVEYMSFSAHADAKGIMQLVGQAEPESVLLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CVQGTVGHKILSGQRKLEMEGRQVLEVKMQVEYMSFSAHADAKGIMQLVGQAEPESVLLV
260 270 280 290 300 310
420 430 440 450 460 470
pF1KB8 HGEAKKMEFLKQKIEQELRVNCYMPANGETVTLPTSPSIPVGISLGLLKREMAQGLLPEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HGEAKKMEFLKQKIEQELRVNCYMPANGETVTLPTSPSIPVGISLGLLKREMAQGLLPEA
320 330 340 350 360 370
480 490 500 510 520 530
pF1KB8 KKPRLLHGTLIMKDSNFRLVSSEQALKELGLAEHQLRFTCRVHLHDTRKEQETALRVYSH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KKPRLLHGTLIMKDSNFRLVSSEQALKELGLAEHQLRFTCRVHLHDTRKEQETALRVYSH
380 390 400 410 420 430
540 550 560 570 580 590
pF1KB8 LKSVLKDHCVQHLPDGSVTVESVLLQAAAPSEDPGTKVLLVSWTYQDEELGSFLTSLLKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LKSVLKDHCVQHLPDGSVTVESVLLQAAAPSEDPGTKVLLVSWTYQDEELGSFLTSLLKK
440 450 460 470 480 490
600
pF1KB8 GLPQAPS
:::::::
NP_001 GLPQAPS
500
600 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 11:33:09 2016 done: Fri Nov 4 11:33:10 2016
Total Scan time: 8.630 Total Display time: 0.120
Function used was FASTA [36.3.4 Apr, 2011]