FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8306, 142 aa 1>>>pF1KB8306 142 - 142 aa - 142 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.7533+/-0.000281; mu= 6.9317+/- 0.018 mean_var=139.2480+/-28.046, 0's: 0 Z-trim(122.3): 13 B-trim: 0 in 0/56 Lambda= 0.108688 statistics sampled from 40224 (40237) to 40224 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.812), E-opt: 0.2 (0.472), width: 16 Scan time: 5.180 The best scores are: opt bits E(85289) NP_001273549 (OMIM: 611110) MAP3K7 C-terminal-like ( 142) 902 151.3 4.8e-37 NP_001273548 (OMIM: 611110) MAP3K7 C-terminal-like ( 142) 902 151.3 4.8e-37 NP_001273546 (OMIM: 611110) MAP3K7 C-terminal-like ( 142) 902 151.3 4.8e-37 NP_001273547 (OMIM: 611110) MAP3K7 C-terminal-like ( 142) 902 151.3 4.8e-37 NP_001273551 (OMIM: 611110) MAP3K7 C-terminal-like ( 136) 768 130.3 9.9e-31 NP_001273563 (OMIM: 611110) MAP3K7 C-terminal-like ( 242) 760 129.3 3.6e-30 NP_064537 (OMIM: 611110) MAP3K7 C-terminal-like pr ( 242) 760 129.3 3.6e-30 NP_001273553 (OMIM: 611110) MAP3K7 C-terminal-like ( 87) 523 91.7 2.6e-19 XP_016866715 (OMIM: 157800,602614,617137) PREDICTE ( 449) 453 81.4 1.8e-15 XP_006715616 (OMIM: 157800,602614,617137) PREDICTE ( 476) 453 81.4 1.8e-15 NP_003179 (OMIM: 157800,602614,617137) mitogen-act ( 579) 453 81.5 2.1e-15 NP_663304 (OMIM: 157800,602614,617137) mitogen-act ( 606) 453 81.5 2.2e-15 >>NP_001273549 (OMIM: 611110) MAP3K7 C-terminal-like pro (142 aa) initn: 902 init1: 902 opt: 902 Z-score: 786.0 bits: 151.3 E(85289): 4.8e-37 Smith-Waterman score: 902; 97.9% identity (99.3% similar) in 142 aa overlap (1-142:1-142) 10 20 30 40 50 60 pF1KB8 MISTARVPADKPVRIAFSLNDASDDTPPEDSIPLVFPELDQQLQPLPPCHDSEESMEVFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::. NP_001 MISTARVPADKPVRIAFSLNDASDDTPPEDSIPLVFPELDQQLQPLPPCHDSEESMEVFK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 QHCQIAEEYLEVKKEITLLEQRKKELIAKLDQAEEEKVDAAELVREFEALTEENRTLRLA ::::::::: ::::::::::::::::::::::::.::::::::::::::::::::::::: NP_001 QHCQIAEEYHEVKKEITLLEQRKKELIAKLDQAEKEKVDAAELVREFEALTEENRTLRLA 70 80 90 100 110 120 130 140 pF1KB8 QSQCVEQLEKLRIQYQKRQGSS :::::::::::::::::::::: NP_001 QSQCVEQLEKLRIQYQKRQGSS 130 140 >>NP_001273548 (OMIM: 611110) MAP3K7 C-terminal-like pro (142 aa) initn: 902 init1: 902 opt: 902 Z-score: 786.0 bits: 151.3 E(85289): 4.8e-37 Smith-Waterman score: 902; 97.9% identity (99.3% similar) in 142 aa overlap (1-142:1-142) 10 20 30 40 50 60 pF1KB8 MISTARVPADKPVRIAFSLNDASDDTPPEDSIPLVFPELDQQLQPLPPCHDSEESMEVFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::. NP_001 MISTARVPADKPVRIAFSLNDASDDTPPEDSIPLVFPELDQQLQPLPPCHDSEESMEVFK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 QHCQIAEEYLEVKKEITLLEQRKKELIAKLDQAEEEKVDAAELVREFEALTEENRTLRLA ::::::::: ::::::::::::::::::::::::.::::::::::::::::::::::::: NP_001 QHCQIAEEYHEVKKEITLLEQRKKELIAKLDQAEKEKVDAAELVREFEALTEENRTLRLA 70 80 90 100 110 120 130 140 pF1KB8 QSQCVEQLEKLRIQYQKRQGSS :::::::::::::::::::::: NP_001 QSQCVEQLEKLRIQYQKRQGSS 130 140 >>NP_001273546 (OMIM: 611110) MAP3K7 C-terminal-like pro (142 aa) initn: 902 init1: 902 opt: 902 Z-score: 786.0 bits: 151.3 E(85289): 4.8e-37 Smith-Waterman score: 902; 97.9% identity (99.3% similar) in 142 aa overlap (1-142:1-142) 10 20 30 40 50 60 pF1KB8 MISTARVPADKPVRIAFSLNDASDDTPPEDSIPLVFPELDQQLQPLPPCHDSEESMEVFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::. NP_001 MISTARVPADKPVRIAFSLNDASDDTPPEDSIPLVFPELDQQLQPLPPCHDSEESMEVFK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 QHCQIAEEYLEVKKEITLLEQRKKELIAKLDQAEEEKVDAAELVREFEALTEENRTLRLA ::::::::: ::::::::::::::::::::::::.::::::::::::::::::::::::: NP_001 QHCQIAEEYHEVKKEITLLEQRKKELIAKLDQAEKEKVDAAELVREFEALTEENRTLRLA 70 80 90 100 110 120 130 140 pF1KB8 QSQCVEQLEKLRIQYQKRQGSS :::::::::::::::::::::: NP_001 QSQCVEQLEKLRIQYQKRQGSS 130 140 >>NP_001273547 (OMIM: 611110) MAP3K7 C-terminal-like pro (142 aa) initn: 902 init1: 902 opt: 902 Z-score: 786.0 bits: 151.3 E(85289): 4.8e-37 Smith-Waterman score: 902; 97.9% identity (99.3% similar) in 142 aa overlap (1-142:1-142) 10 20 30 40 50 60 pF1KB8 MISTARVPADKPVRIAFSLNDASDDTPPEDSIPLVFPELDQQLQPLPPCHDSEESMEVFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::. NP_001 MISTARVPADKPVRIAFSLNDASDDTPPEDSIPLVFPELDQQLQPLPPCHDSEESMEVFK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 QHCQIAEEYLEVKKEITLLEQRKKELIAKLDQAEEEKVDAAELVREFEALTEENRTLRLA ::::::::: ::::::::::::::::::::::::.::::::::::::::::::::::::: NP_001 QHCQIAEEYHEVKKEITLLEQRKKELIAKLDQAEKEKVDAAELVREFEALTEENRTLRLA 70 80 90 100 110 120 130 140 pF1KB8 QSQCVEQLEKLRIQYQKRQGSS :::::::::::::::::::::: NP_001 QSQCVEQLEKLRIQYQKRQGSS 130 140 >>NP_001273551 (OMIM: 611110) MAP3K7 C-terminal-like pro (136 aa) initn: 772 init1: 760 opt: 768 Z-score: 672.7 bits: 130.3 E(85289): 9.9e-31 Smith-Waterman score: 768; 85.2% identity (90.1% similar) in 142 aa overlap (1-142:2-136) 10 20 30 40 50 pF1KB8 MISTARVPADKPVRIAFSLNDASDDTPPEDSIPLVFPELDQQLQPLPPCHDSEESMEVF ..:.. . ::: : :::::::::::::::::::::::::::::::::::: NP_001 MLVSSSSLTPFPPVRTA-------DDTPPEDSIPLVFPELDQQLQPLPPCHDSEESMEVF 10 20 30 40 50 60 70 80 90 100 110 pF1KB8 RQHCQIAEEYLEVKKEITLLEQRKKELIAKLDQAEEEKVDAAELVREFEALTEENRTLRL .::::::::: ::::::::::::::::::::::::.:::::::::::::::::::::::: NP_001 KQHCQIAEEYHEVKKEITLLEQRKKELIAKLDQAEKEKVDAAELVREFEALTEENRTLRL 60 70 80 90 100 110 120 130 140 pF1KB8 AQSQCVEQLEKLRIQYQKRQGSS ::::::::::::::::::::::: NP_001 AQSQCVEQLEKLRIQYQKRQGSS 120 130 >>NP_001273563 (OMIM: 611110) MAP3K7 C-terminal-like pro (242 aa) initn: 759 init1: 759 opt: 760 Z-score: 662.6 bits: 129.3 E(85289): 3.6e-30 Smith-Waterman score: 760; 91.6% identity (93.9% similar) in 131 aa overlap (12-142:115-242) 10 20 30 40 pF1KB8 MISTARVPADKPVRIAFSLNDASDDTPPEDSIPLVFPELDQ ::.: : :::::::::::::::::: NP_001 SLAMLEDNPKVSKLATGDWMLTLKPKSITVPVEIPSS---PLDDTPPEDSIPLVFPELDQ 90 100 110 120 130 140 50 60 70 80 90 100 pF1KB8 QLQPLPPCHDSEESMEVFRQHCQIAEEYLEVKKEITLLEQRKKELIAKLDQAEEEKVDAA ::::::::::::::::::.::::::::: ::::::::::::::::::::::::.:::::: NP_001 QLQPLPPCHDSEESMEVFKQHCQIAEEYHEVKKEITLLEQRKKELIAKLDQAEKEKVDAA 150 160 170 180 190 200 110 120 130 140 pF1KB8 ELVREFEALTEENRTLRLAQSQCVEQLEKLRIQYQKRQGSS ::::::::::::::::::::::::::::::::::::::::: NP_001 ELVREFEALTEENRTLRLAQSQCVEQLEKLRIQYQKRQGSS 210 220 230 240 >>NP_064537 (OMIM: 611110) MAP3K7 C-terminal-like protei (242 aa) initn: 759 init1: 759 opt: 760 Z-score: 662.6 bits: 129.3 E(85289): 3.6e-30 Smith-Waterman score: 760; 91.6% identity (93.9% similar) in 131 aa overlap (12-142:115-242) 10 20 30 40 pF1KB8 MISTARVPADKPVRIAFSLNDASDDTPPEDSIPLVFPELDQ ::.: : :::::::::::::::::: NP_064 SLAMLEDNPKVSKLATGDWMLTLKPKSITVPVEIPSS---PLDDTPPEDSIPLVFPELDQ 90 100 110 120 130 140 50 60 70 80 90 100 pF1KB8 QLQPLPPCHDSEESMEVFRQHCQIAEEYLEVKKEITLLEQRKKELIAKLDQAEEEKVDAA ::::::::::::::::::.::::::::: ::::::::::::::::::::::::.:::::: NP_064 QLQPLPPCHDSEESMEVFKQHCQIAEEYHEVKKEITLLEQRKKELIAKLDQAEKEKVDAA 150 160 170 180 190 200 110 120 130 140 pF1KB8 ELVREFEALTEENRTLRLAQSQCVEQLEKLRIQYQKRQGSS ::::::::::::::::::::::::::::::::::::::::: NP_064 ELVREFEALTEENRTLRLAQSQCVEQLEKLRIQYQKRQGSS 210 220 230 240 >>NP_001273553 (OMIM: 611110) MAP3K7 C-terminal-like pro (87 aa) initn: 523 init1: 523 opt: 523 Z-score: 467.6 bits: 91.7 E(85289): 2.6e-19 Smith-Waterman score: 523; 96.6% identity (98.9% similar) in 87 aa overlap (56-142:1-87) 30 40 50 60 70 80 pF1KB8 TPPEDSIPLVFPELDQQLQPLPPCHDSEESMEVFRQHCQIAEEYLEVKKEITLLEQRKKE ::::.::::::::: ::::::::::::::: NP_001 MEVFKQHCQIAEEYHEVKKEITLLEQRKKE 10 20 30 90 100 110 120 130 140 pF1KB8 LIAKLDQAEEEKVDAAELVREFEALTEENRTLRLAQSQCVEQLEKLRIQYQKRQGSS :::::::::.::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LIAKLDQAEKEKVDAAELVREFEALTEENRTLRLAQSQCVEQLEKLRIQYQKRQGSS 40 50 60 70 80 >>XP_016866715 (OMIM: 157800,602614,617137) PREDICTED: m (449 aa) initn: 450 init1: 410 opt: 453 Z-score: 398.9 bits: 81.4 E(85289): 1.8e-15 Smith-Waterman score: 453; 46.9% identity (79.0% similar) in 143 aa overlap (1-142:307-449) 10 20 pF1KB8 MISTARVPADKPVRI-AFSLNDASDDTPPE ::.:. ..::.: .. .:..: . . XP_016 QPRRRSIQDLTVTGTEPGQVSSRSSSPSVRMITTSGPTSEKPTRSHPWTPDDSTDTNGSD 280 290 300 310 320 330 30 40 50 60 70 80 pF1KB8 DSIPLVFPELDQQLQPLPPCHDSEESMEVFRQHCQIAEEYLEVKKEITLLEQRKKELIAK .:::... ::.::::: :: .:.::: ::.:::..:.::..:. ::.:: :::.::.:. XP_016 NSIPMAYLTLDHQLQPLAPCPNSKESMAVFEQHCKMAQEYMKVQTEIALLLQRKQELVAE 340 350 360 370 380 390 90 100 110 120 130 140 pF1KB8 LDQAEEEKVDAAELVREFEALTEENRTLRLAQSQCVEQLEKLRIQYQKRQGSS ::: :... ....::.: . : .::..: .:: .::: .: : :::::.: XP_016 LDQDEKDQQNTSRLVQEHKKLLDENKSLSTYYQQCKKQLEVIRSQQQKRQGTS 400 410 420 430 440 >>XP_006715616 (OMIM: 157800,602614,617137) PREDICTED: m (476 aa) initn: 450 init1: 410 opt: 453 Z-score: 398.6 bits: 81.4 E(85289): 1.8e-15 Smith-Waterman score: 453; 46.9% identity (79.0% similar) in 143 aa overlap (1-142:334-476) 10 20 pF1KB8 MISTARVPADKPVRI-AFSLNDASDDTPPE ::.:. ..::.: .. .:..: . . XP_006 QPRRRSIQDLTVTGTEPGQVSSRSSSPSVRMITTSGPTSEKPTRSHPWTPDDSTDTNGSD 310 320 330 340 350 360 30 40 50 60 70 80 pF1KB8 DSIPLVFPELDQQLQPLPPCHDSEESMEVFRQHCQIAEEYLEVKKEITLLEQRKKELIAK .:::... ::.::::: :: .:.::: ::.:::..:.::..:. ::.:: :::.::.:. XP_006 NSIPMAYLTLDHQLQPLAPCPNSKESMAVFEQHCKMAQEYMKVQTEIALLLQRKQELVAE 370 380 390 400 410 420 90 100 110 120 130 140 pF1KB8 LDQAEEEKVDAAELVREFEALTEENRTLRLAQSQCVEQLEKLRIQYQKRQGSS ::: :... ....::.: . : .::..: .:: .::: .: : :::::.: XP_006 LDQDEKDQQNTSRLVQEHKKLLDENKSLSTYYQQCKKQLEVIRSQQQKRQGTS 430 440 450 460 470 142 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 11:35:36 2016 done: Fri Nov 4 11:35:37 2016 Total Scan time: 5.180 Total Display time: -0.020 Function used was FASTA [36.3.4 Apr, 2011]