FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8310, 403 aa 1>>>pF1KB8310 403 - 403 aa - 403 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 10.2561+/-0.000529; mu= -6.2590+/- 0.032 mean_var=498.4319+/-111.608, 0's: 0 Z-trim(118.3): 2038 B-trim: 33 in 1/52 Lambda= 0.057448 statistics sampled from 28503 (31191) to 28503 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.726), E-opt: 0.2 (0.366), width: 16 Scan time: 5.760 The best scores are: opt bits E(85289) NP_003591 (OMIM: 603072) aurora kinase A [Homo sap ( 403) 2700 238.8 1.8e-62 NP_001310234 (OMIM: 603072) aurora kinase A [Homo ( 403) 2700 238.8 1.8e-62 NP_940836 (OMIM: 603072) aurora kinase A [Homo sap ( 403) 2700 238.8 1.8e-62 NP_940835 (OMIM: 603072) aurora kinase A [Homo sap ( 403) 2700 238.8 1.8e-62 NP_001310233 (OMIM: 603072) aurora kinase A [Homo ( 403) 2700 238.8 1.8e-62 NP_940838 (OMIM: 603072) aurora kinase A [Homo sap ( 403) 2700 238.8 1.8e-62 NP_940837 (OMIM: 603072) aurora kinase A [Homo sap ( 403) 2700 238.8 1.8e-62 NP_940839 (OMIM: 603072) aurora kinase A [Homo sap ( 403) 2700 238.8 1.8e-62 XP_016883524 (OMIM: 603072) PREDICTED: aurora kina ( 403) 2700 238.8 1.8e-62 NP_001310232 (OMIM: 603072) aurora kinase A [Homo ( 403) 2700 238.8 1.8e-62 XP_016883523 (OMIM: 603072) PREDICTED: aurora kina ( 437) 2700 238.8 1.9e-62 NP_001300881 (OMIM: 604970) aurora kinase B isofor ( 304) 1351 126.8 7e-29 NP_001271455 (OMIM: 604970) aurora kinase B isofor ( 345) 1351 126.9 7.5e-29 NP_001300880 (OMIM: 604970) aurora kinase B isofor ( 303) 1348 126.6 8.3e-29 NP_001243763 (OMIM: 604970) aurora kinase B isofor ( 303) 1348 126.6 8.3e-29 XP_011522374 (OMIM: 604970) PREDICTED: aurora kina ( 303) 1348 126.6 8.3e-29 XP_016880796 (OMIM: 604970) PREDICTED: aurora kina ( 303) 1348 126.6 8.3e-29 NP_004208 (OMIM: 604970) aurora kinase B isoform 1 ( 344) 1348 126.6 8.9e-29 NP_001300879 (OMIM: 604970) aurora kinase B isofor ( 344) 1348 126.6 8.9e-29 NP_001015878 (OMIM: 243060,603495) aurora kinase C ( 309) 1316 123.9 5.3e-28 NP_001015879 (OMIM: 243060,603495) aurora kinase C ( 290) 1311 123.5 6.8e-28 NP_003151 (OMIM: 243060,603495) aurora kinase C is ( 275) 1309 123.3 7.3e-28 XP_016880797 (OMIM: 604970) PREDICTED: aurora kina ( 271) 1004 98.0 3e-20 NP_001300882 (OMIM: 604970) aurora kinase B isofor ( 312) 1004 98.1 3.2e-20 XP_011522372 (OMIM: 604970) PREDICTED: aurora kina ( 312) 1004 98.1 3.2e-20 NP_001300883 (OMIM: 604970) aurora kinase B isofor ( 192) 796 80.5 3.7e-15 XP_016880799 (OMIM: 604970) PREDICTED: aurora kina ( 192) 796 80.5 3.7e-15 XP_016880798 (OMIM: 604970) PREDICTED: aurora kina ( 192) 796 80.5 3.7e-15 XP_016880800 (OMIM: 604970) PREDICTED: aurora kina ( 192) 796 80.5 3.7e-15 NP_001300884 (OMIM: 604970) aurora kinase B isofor ( 176) 779 79.1 9.4e-15 XP_005262758 (OMIM: 605031,616171) PREDICTED: seri ( 936) 663 70.5 2e-11 XP_016863152 (OMIM: 605031,616171) PREDICTED: seri ( 937) 663 70.5 2e-11 NP_055079 (OMIM: 605031,616171) serine/threonine-p ( 970) 663 70.5 2e-11 XP_016863151 (OMIM: 605031,616171) PREDICTED: seri ( 971) 663 70.5 2e-11 NP_001094064 (OMIM: 612760) SNF-related serine/thr ( 765) 593 64.5 9.8e-10 XP_005265302 (OMIM: 612760) PREDICTED: SNF-related ( 765) 593 64.5 9.8e-10 NP_060189 (OMIM: 612760) SNF-related serine/threon ( 765) 593 64.5 9.8e-10 NP_001271293 (OMIM: 613472) serine/threonine-prote ( 470) 580 63.2 1.6e-09 NP_001092906 (OMIM: 613472) serine/threonine-prote ( 472) 580 63.2 1.6e-09 NP_003943 (OMIM: 608939) ribosomal protein S6 kina ( 482) 576 62.9 2e-09 NP_001156769 (OMIM: 600526) serine/threonine-prote ( 709) 579 63.3 2.1e-09 NP_001156768 (OMIM: 600526) serine/threonine-prote ( 719) 579 63.3 2.1e-09 NP_004945 (OMIM: 600526) serine/threonine-protein ( 724) 579 63.3 2.1e-09 XP_016872799 (OMIM: 600526) PREDICTED: serine/thre ( 763) 579 63.4 2.2e-09 NP_001034558 (OMIM: 600526) serine/threonine-prote ( 788) 579 63.4 2.2e-09 NP_001248745 (OMIM: 605213) 3-phosphoinositide-dep ( 454) 572 62.5 2.4e-09 XP_005267700 (OMIM: 602678) PREDICTED: MAP/microtu ( 643) 575 62.9 2.5e-09 NP_113605 (OMIM: 606495) MAP/microtubule affinity- ( 688) 575 63.0 2.6e-09 XP_016876782 (OMIM: 602678) PREDICTED: MAP/microtu ( 708) 575 63.0 2.6e-09 NP_001122392 (OMIM: 602678) MAP/microtubule affini ( 713) 575 63.0 2.6e-09 >>NP_003591 (OMIM: 603072) aurora kinase A [Homo sapiens (403 aa) initn: 2700 init1: 2700 opt: 2700 Z-score: 1242.5 bits: 238.8 E(85289): 1.8e-62 Smith-Waterman score: 2700; 99.8% identity (100.0% similar) in 403 aa overlap (1-403:1-403) 10 20 30 40 50 60 pF1KB8 MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRVPLQ ::::::::::::::::::::::::::::::::::::::::::::::::::::::::.::: NP_003 MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRIPLQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 AQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 AQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 EESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 EESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 EVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 EVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITEL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 ANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 ANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEM 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 IEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 IEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLI 310 320 330 340 350 360 370 380 390 400 pF1KB8 SRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQS ::::::::::::::::::::::::::::::::::::::::::: NP_003 SRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQS 370 380 390 400 >>NP_001310234 (OMIM: 603072) aurora kinase A [Homo sapi (403 aa) initn: 2700 init1: 2700 opt: 2700 Z-score: 1242.5 bits: 238.8 E(85289): 1.8e-62 Smith-Waterman score: 2700; 99.8% identity (100.0% similar) in 403 aa overlap (1-403:1-403) 10 20 30 40 50 60 pF1KB8 MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRVPLQ ::::::::::::::::::::::::::::::::::::::::::::::::::::::::.::: NP_001 MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRIPLQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 AQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 EESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 EVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITEL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 ANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEM 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 IEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLI 310 320 330 340 350 360 370 380 390 400 pF1KB8 SRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQS ::::::::::::::::::::::::::::::::::::::::::: NP_001 SRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQS 370 380 390 400 >>NP_940836 (OMIM: 603072) aurora kinase A [Homo sapiens (403 aa) initn: 2700 init1: 2700 opt: 2700 Z-score: 1242.5 bits: 238.8 E(85289): 1.8e-62 Smith-Waterman score: 2700; 99.8% identity (100.0% similar) in 403 aa overlap (1-403:1-403) 10 20 30 40 50 60 pF1KB8 MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRVPLQ ::::::::::::::::::::::::::::::::::::::::::::::::::::::::.::: NP_940 MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRIPLQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 AQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_940 AQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 EESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_940 EESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 EVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_940 EVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITEL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 ANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_940 ANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEM 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 IEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_940 IEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLI 310 320 330 340 350 360 370 380 390 400 pF1KB8 SRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQS ::::::::::::::::::::::::::::::::::::::::::: NP_940 SRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQS 370 380 390 400 >>NP_940835 (OMIM: 603072) aurora kinase A [Homo sapiens (403 aa) initn: 2700 init1: 2700 opt: 2700 Z-score: 1242.5 bits: 238.8 E(85289): 1.8e-62 Smith-Waterman score: 2700; 99.8% identity (100.0% similar) in 403 aa overlap (1-403:1-403) 10 20 30 40 50 60 pF1KB8 MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRVPLQ ::::::::::::::::::::::::::::::::::::::::::::::::::::::::.::: NP_940 MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRIPLQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 AQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_940 AQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 EESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_940 EESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 EVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_940 EVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITEL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 ANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_940 ANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEM 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 IEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_940 IEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLI 310 320 330 340 350 360 370 380 390 400 pF1KB8 SRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQS ::::::::::::::::::::::::::::::::::::::::::: NP_940 SRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQS 370 380 390 400 >>NP_001310233 (OMIM: 603072) aurora kinase A [Homo sapi (403 aa) initn: 2700 init1: 2700 opt: 2700 Z-score: 1242.5 bits: 238.8 E(85289): 1.8e-62 Smith-Waterman score: 2700; 99.8% identity (100.0% similar) in 403 aa overlap (1-403:1-403) 10 20 30 40 50 60 pF1KB8 MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRVPLQ ::::::::::::::::::::::::::::::::::::::::::::::::::::::::.::: NP_001 MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRIPLQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 AQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 EESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 EVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITEL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 ANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEM 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 IEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLI 310 320 330 340 350 360 370 380 390 400 pF1KB8 SRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQS ::::::::::::::::::::::::::::::::::::::::::: NP_001 SRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQS 370 380 390 400 >>NP_940838 (OMIM: 603072) aurora kinase A [Homo sapiens (403 aa) initn: 2700 init1: 2700 opt: 2700 Z-score: 1242.5 bits: 238.8 E(85289): 1.8e-62 Smith-Waterman score: 2700; 99.8% identity (100.0% similar) in 403 aa overlap (1-403:1-403) 10 20 30 40 50 60 pF1KB8 MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRVPLQ ::::::::::::::::::::::::::::::::::::::::::::::::::::::::.::: NP_940 MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRIPLQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 AQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_940 AQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 EESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_940 EESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 EVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_940 EVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITEL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 ANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_940 ANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEM 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 IEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_940 IEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLI 310 320 330 340 350 360 370 380 390 400 pF1KB8 SRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQS ::::::::::::::::::::::::::::::::::::::::::: NP_940 SRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQS 370 380 390 400 >>NP_940837 (OMIM: 603072) aurora kinase A [Homo sapiens (403 aa) initn: 2700 init1: 2700 opt: 2700 Z-score: 1242.5 bits: 238.8 E(85289): 1.8e-62 Smith-Waterman score: 2700; 99.8% identity (100.0% similar) in 403 aa overlap (1-403:1-403) 10 20 30 40 50 60 pF1KB8 MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRVPLQ ::::::::::::::::::::::::::::::::::::::::::::::::::::::::.::: NP_940 MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRIPLQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 AQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_940 AQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 EESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_940 EESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 EVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_940 EVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITEL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 ANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_940 ANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEM 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 IEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_940 IEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLI 310 320 330 340 350 360 370 380 390 400 pF1KB8 SRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQS ::::::::::::::::::::::::::::::::::::::::::: NP_940 SRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQS 370 380 390 400 >>NP_940839 (OMIM: 603072) aurora kinase A [Homo sapiens (403 aa) initn: 2700 init1: 2700 opt: 2700 Z-score: 1242.5 bits: 238.8 E(85289): 1.8e-62 Smith-Waterman score: 2700; 99.8% identity (100.0% similar) in 403 aa overlap (1-403:1-403) 10 20 30 40 50 60 pF1KB8 MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRVPLQ ::::::::::::::::::::::::::::::::::::::::::::::::::::::::.::: NP_940 MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRIPLQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 AQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_940 AQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 EESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_940 EESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 EVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_940 EVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITEL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 ANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_940 ANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEM 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 IEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_940 IEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLI 310 320 330 340 350 360 370 380 390 400 pF1KB8 SRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQS ::::::::::::::::::::::::::::::::::::::::::: NP_940 SRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQS 370 380 390 400 >>XP_016883524 (OMIM: 603072) PREDICTED: aurora kinase A (403 aa) initn: 2700 init1: 2700 opt: 2700 Z-score: 1242.5 bits: 238.8 E(85289): 1.8e-62 Smith-Waterman score: 2700; 99.8% identity (100.0% similar) in 403 aa overlap (1-403:1-403) 10 20 30 40 50 60 pF1KB8 MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRVPLQ ::::::::::::::::::::::::::::::::::::::::::::::::::::::::.::: XP_016 MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRIPLQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 AQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 EESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 EVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITEL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 ANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEM 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 IEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLI 310 320 330 340 350 360 370 380 390 400 pF1KB8 SRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQS ::::::::::::::::::::::::::::::::::::::::::: XP_016 SRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQS 370 380 390 400 >>NP_001310232 (OMIM: 603072) aurora kinase A [Homo sapi (403 aa) initn: 2700 init1: 2700 opt: 2700 Z-score: 1242.5 bits: 238.8 E(85289): 1.8e-62 Smith-Waterman score: 2700; 99.8% identity (100.0% similar) in 403 aa overlap (1-403:1-403) 10 20 30 40 50 60 pF1KB8 MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRVPLQ ::::::::::::::::::::::::::::::::::::::::::::::::::::::::.::: NP_001 MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRIPLQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 AQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 EESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 EVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITEL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 ANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEM 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 IEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLI 310 320 330 340 350 360 370 380 390 400 pF1KB8 SRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQS ::::::::::::::::::::::::::::::::::::::::::: NP_001 SRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQS 370 380 390 400 403 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 11:36:39 2016 done: Fri Nov 4 11:36:40 2016 Total Scan time: 5.760 Total Display time: 0.020 Function used was FASTA [36.3.4 Apr, 2011]