FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8320, 129 aa 1>>>pF1KB8320 129 - 129 aa - 129 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.5778+/-0.000388; mu= 15.0844+/- 0.024 mean_var=71.4997+/-15.608, 0's: 0 Z-trim(114.5): 278 B-trim: 2645 in 3/51 Lambda= 0.151678 statistics sampled from 23921 (24311) to 23921 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.678), E-opt: 0.2 (0.285), width: 16 Scan time: 3.660 The best scores are: opt bits E(85289) NP_056358 (OMIM: 179508) ras-related protein Rab-1 ( 129) 830 190.1 8.3e-49 XP_005264525 (OMIM: 179508) PREDICTED: ras-related ( 173) 426 101.8 4.2e-22 NP_004152 (OMIM: 179508) ras-related protein Rab-1 ( 205) 426 101.9 4.7e-22 NP_112243 (OMIM: 612565) ras-related protein Rab-1 ( 201) 390 94.0 1.1e-19 XP_016873867 (OMIM: 612565) PREDICTED: ras-related ( 237) 390 94.1 1.2e-19 XP_011519971 (OMIM: 613532) PREDICTED: ras-related ( 122) 312 76.7 1.1e-14 NP_057614 (OMIM: 613532) ras-related protein Rab-8 ( 207) 312 77.0 1.5e-14 NP_005361 (OMIM: 165040) ras-related protein Rab-8 ( 207) 308 76.1 2.8e-14 XP_011526322 (OMIM: 165040) PREDICTED: ras-related ( 215) 308 76.1 2.9e-14 NP_002861 (OMIM: 602672) ras-related protein Rab-1 ( 203) 298 73.9 1.3e-13 NP_001161078 (OMIM: 604199) ras-related protein Ra ( 152) 295 73.1 1.6e-13 NP_006852 (OMIM: 604199) ras-related protein Rab-3 ( 201) 295 73.2 2e-13 NP_057215 (OMIM: 612672) ras-related protein Rab-1 ( 200) 288 71.7 5.7e-13 NP_002857 (OMIM: 179490) ras-related protein Rab-3 ( 220) 242 61.7 6.5e-10 XP_011526466 (OMIM: 179490) PREDICTED: ras-related ( 220) 242 61.7 6.5e-10 NP_004274 (OMIM: 604350) ras-related protein Rab-3 ( 219) 241 61.5 7.6e-10 NP_001304844 (OMIM: 612829) ras-related protein Ra ( 225) 241 61.5 7.7e-10 NP_612462 (OMIM: 612829) ras-related protein Rab-3 ( 227) 241 61.5 7.8e-10 NP_001193765 (OMIM: 605570) ras-related protein Ra ( 155) 237 60.4 1.1e-09 XP_016857447 (OMIM: 179510) PREDICTED: ras-related ( 219) 238 60.8 1.2e-09 NP_002858 (OMIM: 179510) ras-related protein Rab-3 ( 219) 238 60.8 1.2e-09 NP_004654 (OMIM: 605570) ras-related protein Rab-1 ( 216) 237 60.6 1.4e-09 NP_004209 (OMIM: 604198) ras-related protein Rab-1 ( 218) 237 60.6 1.4e-09 XP_011520750 (OMIM: 605455) PREDICTED: ras-related ( 231) 222 57.3 1.4e-08 NP_055168 (OMIM: 605455) ras-related protein Rab-2 ( 256) 222 57.4 1.5e-08 NP_001272989 (OMIM: 605693) ras-related protein Ra ( 203) 220 56.8 1.7e-08 NP_055303 (OMIM: 605693) ras-related protein Rab-3 ( 203) 220 56.8 1.7e-08 NP_001272988 (OMIM: 605693) ras-related protein Ra ( 203) 220 56.8 1.7e-08 NP_001272990 (OMIM: 605693) ras-related protein Ra ( 203) 220 56.8 1.7e-08 NP_002856 (OMIM: 179509) ras-related protein Rab-2 ( 212) 220 56.9 1.8e-08 NP_116235 (OMIM: 607466) ras-related protein Rab-2 ( 216) 220 56.9 1.8e-08 NP_001020471 (OMIM: 616448) ras-related protein Ra ( 244) 215 55.8 4.2e-08 NP_001243341 (OMIM: 602207,614222) ras-related pro ( 142) 211 54.7 5.3e-08 NP_001243340 (OMIM: 602207,614222) ras-related pro ( 197) 211 54.9 6.6e-08 NP_067075 (OMIM: 602207,614222) ras-related protei ( 206) 211 54.9 6.9e-08 NP_001243339 (OMIM: 602207,614222) ras-related pro ( 235) 211 54.9 7.5e-08 NP_057238 (OMIM: 612945) ras-related protein Rab-4 ( 213) 206 53.8 1.5e-07 NP_001006639 (OMIM: 609956) ras-related protein Ra ( 223) 206 53.8 1.5e-07 NP_057406 (OMIM: 612673) ras-related protein Rab-1 ( 215) 199 52.3 4.4e-07 NP_004569 (OMIM: 179511) ras-related protein Rab-4 ( 218) 199 52.3 4.4e-07 NP_112586 (OMIM: 605950,615222) ras-related protei ( 229) 196 51.6 7.2e-07 XP_011530601 (OMIM: 605950,615222) PREDICTED: ras- ( 277) 196 51.7 8.2e-07 NP_001294982 (OMIM: 605455) ras-related protein Ra ( 190) 194 51.1 8.5e-07 NP_004785 (OMIM: 300333) ras-related protein Rab-3 ( 237) 194 51.2 1e-06 XP_011524433 (OMIM: 603869) PREDICTED: ras-related ( 182) 189 50.0 1.8e-06 XP_006722581 (OMIM: 603869) PREDICTED: ras-related ( 182) 189 50.0 1.8e-06 XP_005266790 (OMIM: 603869) PREDICTED: ras-related ( 218) 189 50.1 2e-06 XP_016881402 (OMIM: 603869) PREDICTED: ras-related ( 218) 189 50.1 2e-06 NP_004154 (OMIM: 603869) ras-related protein Rab-2 ( 218) 189 50.1 2e-06 XP_016881403 (OMIM: 603869) PREDICTED: ras-related ( 218) 189 50.1 2e-06 >>NP_056358 (OMIM: 179508) ras-related protein Rab-1A is (129 aa) initn: 830 init1: 830 opt: 830 Z-score: 997.2 bits: 190.1 E(85289): 8.3e-49 Smith-Waterman score: 830; 100.0% identity (100.0% similar) in 129 aa overlap (1-129:1-129) 10 20 30 40 50 60 pF1KB8 MSSMNPEYDYLFKLLLIGDSGVGKSCLLLRFADDTYTESYISTIGVDFKIRTIELDGKTI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 MSSMNPEYDYLFKLLLIGDSGVGKSCLLLRFADDTYTESYISTIGVDFKIRTIELDGKTI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 KLQIEFADSLGIPFLETSAKNATNVEQSFMTMAAEIKKRMGPGATAGGAEKSNVKIQSTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 KLQIEFADSLGIPFLETSAKNATNVEQSFMTMAAEIKKRMGPGATAGGAEKSNVKIQSTP 70 80 90 100 110 120 pF1KB8 VKQSGGGCC ::::::::: NP_056 VKQSGGGCC >>XP_005264525 (OMIM: 179508) PREDICTED: ras-related pro (173 aa) initn: 425 init1: 423 opt: 426 Z-score: 517.8 bits: 101.8 E(85289): 4.2e-22 Smith-Waterman score: 648; 72.7% identity (72.7% similar) in 161 aa overlap (13-129:13-173) 10 20 30 40 50 60 pF1KB8 MSSMNPEYDYLFKLLLIGDSGVGKSCLLLRFADDTYTESYISTIGVDFKIRTIELDGKTI :::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MSSMNPEYDYLFKLLLIGDSGVGKSCLLLRFADDTYTESYISTIGVDFKIRTIELDGKTI 10 20 30 40 50 60 70 pF1KB8 KLQIE--------------------------------------------FADSLGIPFLE ::::: ::::::::::: XP_005 KLQIESFNNVKQWLQEIDRYASENVNKLLVGNKCDLTTKKVVDYTTAKEFADSLGIPFLE 70 80 90 100 110 120 80 90 100 110 120 pF1KB8 TSAKNATNVEQSFMTMAAEIKKRMGPGATAGGAEKSNVKIQSTPVKQSGGGCC ::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TSAKNATNVEQSFMTMAAEIKKRMGPGATAGGAEKSNVKIQSTPVKQSGGGCC 130 140 150 160 170 >>NP_004152 (OMIM: 179508) ras-related protein Rab-1A is (205 aa) initn: 816 init1: 423 opt: 426 Z-score: 516.9 bits: 101.9 E(85289): 4.7e-22 Smith-Waterman score: 426; 71.0% identity (84.0% similar) in 100 aa overlap (30-129:111-205) 10 20 30 40 50 pF1KB8 MSSMNPEYDYLFKLLLIGDSGVGKSCLLLRFADDTYTESYISTIGVDFKIRTIELDGKT :.:... .. ... :. . . .: : NP_004 YRGAHGIIVVYDVTDQESFNNVKQWLQEIDRYASENVNKLLVGN-KCDLTTKKV-VDYTT 90 100 110 120 130 60 70 80 90 100 110 pF1KB8 IKLQIEFADSLGIPFLETSAKNATNVEQSFMTMAAEIKKRMGPGATAGGAEKSNVKIQST : ::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 AK---EFADSLGIPFLETSAKNATNVEQSFMTMAAEIKKRMGPGATAGGAEKSNVKIQST 140 150 160 170 180 190 120 pF1KB8 PVKQSGGGCC :::::::::: NP_004 PVKQSGGGCC 200 >-- initn: 416 init1: 407 opt: 407 Z-score: 494.5 bits: 97.8 E(85289): 8.4e-21 Smith-Waterman score: 407; 100.0% identity (100.0% similar) in 64 aa overlap (1-64:1-64) 10 20 30 40 50 60 pF1KB8 MSSMNPEYDYLFKLLLIGDSGVGKSCLLLRFADDTYTESYISTIGVDFKIRTIELDGKTI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 MSSMNPEYDYLFKLLLIGDSGVGKSCLLLRFADDTYTESYISTIGVDFKIRTIELDGKTI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 KLQIEFADSLGIPFLETSAKNATNVEQSFMTMAAEIKKRMGPGATAGGAEKSNVKIQSTP :::: NP_004 KLQIWDTAGQERFRTITSSYYRGAHGIIVVYDVTDQESFNNVKQWLQEIDRYASENVNKL 70 80 90 100 110 120 >>NP_112243 (OMIM: 612565) ras-related protein Rab-1B [H (201 aa) initn: 641 init1: 390 opt: 390 Z-score: 474.5 bits: 94.0 E(85289): 1.1e-19 Smith-Waterman score: 390; 100.0% identity (100.0% similar) in 61 aa overlap (4-64:1-61) 10 20 30 40 50 60 pF1KB8 MSSMNPEYDYLFKLLLIGDSGVGKSCLLLRFADDTYTESYISTIGVDFKIRTIELDGKTI ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_112 MNPEYDYLFKLLLIGDSGVGKSCLLLRFADDTYTESYISTIGVDFKIRTIELDGKTI 10 20 30 40 50 70 80 90 100 110 120 pF1KB8 KLQIEFADSLGIPFLETSAKNATNVEQSFMTMAAEIKKRMGPGATAGGAEKSNVKIQSTP :::: NP_112 KLQIWDTAGQERFRTITSSYYRGAHGIIVVYDVTDQESYANVKQWLQEIDRYASENVNKL 60 70 80 90 100 110 >-- initn: 275 init1: 265 opt: 367 Z-score: 447.3 bits: 89.0 E(85289): 3.6e-18 Smith-Waterman score: 367; 61.0% identity (83.0% similar) in 100 aa overlap (30-129:108-201) 10 20 30 40 50 pF1KB8 MSSMNPEYDYLFKLLLIGDSGVGKSCLLLRFADDTYTESYISTIGVDFKIRTIELDGKT :.:... .. ... . :. . . .:. : NP_112 YRGAHGIIVVYDVTDQESYANVKQWLQEIDRYASENVNKLLVGNKS-DLTTKKV-VDNTT 80 90 100 110 120 130 60 70 80 90 100 110 pF1KB8 IKLQIEFADSLGIPFLETSAKNATNVEQSFMTMAAEIKKRMGPGATAGGAEKSNVKIQST : :::::::::::::::::::::::.::::::::::::::::..:: :. :.::.:: NP_112 AK---EFADSLGIPFLETSAKNATNVEQAFMTMAAEIKKRMGPGAASGG-ERPNLKIDST 140 150 160 170 180 190 120 pF1KB8 PVKQSGGGCC ::: .::::: NP_112 PVKPAGGGCC 200 >>XP_016873867 (OMIM: 612565) PREDICTED: ras-related pro (237 aa) initn: 641 init1: 390 opt: 390 Z-score: 473.6 bits: 94.1 E(85289): 1.2e-19 Smith-Waterman score: 390; 100.0% identity (100.0% similar) in 61 aa overlap (4-64:1-61) 10 20 30 40 50 60 pF1KB8 MSSMNPEYDYLFKLLLIGDSGVGKSCLLLRFADDTYTESYISTIGVDFKIRTIELDGKTI ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MNPEYDYLFKLLLIGDSGVGKSCLLLRFADDTYTESYISTIGVDFKIRTIELDGKTI 10 20 30 40 50 70 80 90 100 110 120 pF1KB8 KLQIEFADSLGIPFLETSAKNATNVEQSFMTMAAEIKKRMGPGATAGGAEKSNVKIQSTP :::: XP_016 KLQIWDTAGQERFRTITSSYYRGAHGIIVVYDVTDQESYANVKQWLQEIDRYASENVNKL 60 70 80 90 100 110 >-- initn: 275 init1: 265 opt: 361 Z-score: 439.3 bits: 87.8 E(85289): 9.9e-18 Smith-Waterman score: 361; 84.6% identity (95.4% similar) in 65 aa overlap (65-129:174-237) 40 50 60 70 80 90 pF1KB8 TYTESYISTIGVDFKIRTIELDGKTIKLQIEFADSLGIPFLETSAKNATNVEQSFMTMAA :::::::::::::::::::::::.:::::: XP_016 CPGSGRWGLLPLTCSPLLFSPLLFSPLPCQEFADSLGIPFLETSAKNATNVEQAFMTMAA 150 160 170 180 190 200 100 110 120 pF1KB8 EIKKRMGPGATAGGAEKSNVKIQSTPVKQSGGGCC ::::::::::..:: :. :.::.::::: .::::: XP_016 EIKKRMGPGAASGG-ERPNLKIDSTPVKPAGGGCC 210 220 230 >>XP_011519971 (OMIM: 613532) PREDICTED: ras-related pro (122 aa) initn: 324 init1: 312 opt: 312 Z-score: 384.9 bits: 76.7 E(85289): 1.1e-14 Smith-Waterman score: 312; 75.4% identity (91.8% similar) in 61 aa overlap (4-64:1-61) 10 20 30 40 50 60 pF1KB8 MSSMNPEYDYLFKLLLIGDSGVGKSCLLLRFADDTYTESYISTIGVDFKIRTIELDGKTI : :::::::::::::::::.:::.::..:... ..:::::.:::::::::::: : XP_011 MAKTYDYLFKLLLIGDSGVGKTCLLFRFSEDAFNTTFISTIGIDFKIRTIELDGKKI 10 20 30 40 50 70 80 90 100 110 120 pF1KB8 KLQIEFADSLGIPFLETSAKNATNVEQSFMTMAAEIKKRMGPGATAGGAEKSNVKIQSTP :::: XP_011 KLQIWDTAGQERFRTITTAYYRGAMPCHHYLLPHHLHNIHCCGSSPCHPPDHHSASWPER 60 70 80 90 100 110 >>NP_057614 (OMIM: 613532) ras-related protein Rab-8B [H (207 aa) initn: 402 init1: 312 opt: 312 Z-score: 382.1 bits: 77.0 E(85289): 1.5e-14 Smith-Waterman score: 312; 75.4% identity (91.8% similar) in 61 aa overlap (4-64:1-61) 10 20 30 40 50 60 pF1KB8 MSSMNPEYDYLFKLLLIGDSGVGKSCLLLRFADDTYTESYISTIGVDFKIRTIELDGKTI : :::::::::::::::::.:::.::..:... ..:::::.:::::::::::: : NP_057 MAKTYDYLFKLLLIGDSGVGKTCLLFRFSEDAFNTTFISTIGIDFKIRTIELDGKKI 10 20 30 40 50 70 80 90 100 110 120 pF1KB8 KLQIEFADSLGIPFLETSAKNATNVEQSFMTMAAEIKKRMGPGATAGGAEKSNVKIQSTP :::: NP_057 KLQIWDTAGQERFRTITTAYYRGAMGIMLVYDITNEKSFDNIKNWIRNIEEHASSDVERM 60 70 80 90 100 110 >>NP_005361 (OMIM: 165040) ras-related protein Rab-8A [H (207 aa) initn: 423 init1: 308 opt: 308 Z-score: 377.3 bits: 76.1 E(85289): 2.8e-14 Smith-Waterman score: 308; 73.8% identity (91.8% similar) in 61 aa overlap (4-64:1-61) 10 20 30 40 50 60 pF1KB8 MSSMNPEYDYLFKLLLIGDSGVGKSCLLLRFADDTYTESYISTIGVDFKIRTIELDGKTI : :::::::::::::::::.:.:.::..:... ..:::::.:::::::::::: : NP_005 MAKTYDYLFKLLLIGDSGVGKTCVLFRFSEDAFNSTFISTIGIDFKIRTIELDGKRI 10 20 30 40 50 70 80 90 100 110 120 pF1KB8 KLQIEFADSLGIPFLETSAKNATNVEQSFMTMAAEIKKRMGPGATAGGAEKSNVKIQSTP :::: NP_005 KLQIWDTAGQERFRTITTAYYRGAMGIMLVYDITNEKSFDNIRNWIRNIEEHASADVEKM 60 70 80 90 100 110 >>XP_011526322 (OMIM: 165040) PREDICTED: ras-related pro (215 aa) initn: 401 init1: 308 opt: 308 Z-score: 377.1 bits: 76.1 E(85289): 2.9e-14 Smith-Waterman score: 308; 73.8% identity (91.8% similar) in 61 aa overlap (4-64:1-61) 10 20 30 40 50 60 pF1KB8 MSSMNPEYDYLFKLLLIGDSGVGKSCLLLRFADDTYTESYISTIGVDFKIRTIELDGKTI : :::::::::::::::::.:.:.::..:... ..:::::.:::::::::::: : XP_011 MAKTYDYLFKLLLIGDSGVGKTCVLFRFSEDAFNSTFISTIGIDFKIRTIELDGKRI 10 20 30 40 50 70 80 90 100 110 120 pF1KB8 KLQIEFADSLGIPFLETSAKNATNVEQSFMTMAAEIKKRMGPGATAGGAEKSNVKIQSTP :::: XP_011 KLQIWDTAGQERFRTITTAYYRGAMGIMLVYDITNEKSFDNIRNWIRNIEEHASADVEKM 60 70 80 90 100 110 >>NP_002861 (OMIM: 602672) ras-related protein Rab-13 is (203 aa) initn: 365 init1: 294 opt: 298 Z-score: 365.6 bits: 73.9 E(85289): 1.3e-13 Smith-Waterman score: 298; 67.2% identity (93.4% similar) in 61 aa overlap (4-64:1-61) 10 20 30 40 50 60 pF1KB8 MSSMNPEYDYLFKLLLIGDSGVGKSCLLLRFADDTYTESYISTIGVDFKIRTIELDGKTI : ::.::::::::::::::.::..:::.:.....::::::.::::::....:: : NP_002 MAKAYDHLFKLLLIGDSGVGKTCLIIRFAEDNFNNTYISTIGIDFKIRTVDIEGKKI 10 20 30 40 50 70 80 90 100 110 120 pF1KB8 KLQIEFADSLGIPFLETSAKNATNVEQSFMTMAAEIKKRMGPGATAGGAEKSNVKIQSTP :::. NP_002 KLQVWDTAGQERFKTITTAYYRGAMGIILVYDITDEKSFENIQNWMKSIKENASAGVERL 60 70 80 90 100 110 129 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 11:43:18 2016 done: Fri Nov 4 11:43:19 2016 Total Scan time: 3.660 Total Display time: -0.020 Function used was FASTA [36.3.4 Apr, 2011]