FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8333, 313 aa 1>>>pF1KB8333 313 - 313 aa - 313 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.0430+/-0.000402; mu= 17.3676+/- 0.025 mean_var=69.5191+/-13.740, 0's: 0 Z-trim(112.9): 110 B-trim: 1234 in 1/49 Lambda= 0.153823 statistics sampled from 21856 (21971) to 21856 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.632), E-opt: 0.2 (0.258), width: 16 Scan time: 4.570 The best scores are: opt bits E(85289) NP_001129522 (OMIM: 610410) dehydrogenase/reductas ( 313) 2085 471.8 7.9e-133 NP_612461 (OMIM: 610410) dehydrogenase/reductase S ( 313) 2085 471.8 7.9e-133 NP_060911 (OMIM: 605843) peroxisomal trans-2-enoyl ( 303) 229 59.9 7.6e-09 NP_055049 (OMIM: 601417) estradiol 17-beta-dehydro ( 261) 228 59.6 7.8e-09 NP_077284 (OMIM: 616159) dehydrogenase/reductase S ( 260) 223 58.5 1.7e-08 NP_001317504 (OMIM: 222745) 2,4-dienoyl-CoA reduct ( 326) 216 57.0 5.9e-08 XP_016868636 (OMIM: 222745) PREDICTED: 2,4-dienoyl ( 326) 216 57.0 5.9e-08 XP_011515182 (OMIM: 222745) PREDICTED: 2,4-dienoyl ( 326) 216 57.0 5.9e-08 XP_016868637 (OMIM: 222745) PREDICTED: 2,4-dienoyl ( 326) 216 57.0 5.9e-08 NP_001350 (OMIM: 222745) 2,4-dienoyl-CoA reductase ( 335) 216 57.0 6e-08 NP_057110 (OMIM: 607849,616108) retinol dehydrogen ( 318) 209 55.5 1.7e-07 NP_689656 (OMIM: 608830,612712) retinol dehydrogen ( 316) 204 54.4 3.7e-07 NP_066284 (OMIM: 611596) dehydrogenase/reductase S ( 278) 199 53.2 7.1e-07 NP_001193670 (OMIM: 600713,614662) corticosteroid ( 292) 197 52.8 1e-06 NP_861420 (OMIM: 600713,614662) corticosteroid 11- ( 292) 197 52.8 1e-06 NP_005516 (OMIM: 600713,614662) corticosteroid 11- ( 292) 197 52.8 1e-06 NP_004744 (OMIM: 612830) short-chain dehydrogenase ( 302) 197 52.8 1e-06 XP_005257715 (OMIM: 616159) PREDICTED: dehydrogena ( 229) 195 52.3 1.1e-06 NP_002026 (OMIM: 136440) 3-ketodihydrosphingosine ( 332) 189 51.0 3.8e-06 XP_005259027 (OMIM: 612832) PREDICTED: 17-beta-hyd ( 140) 184 49.7 4.2e-06 XP_005259026 (OMIM: 612832) PREDICTED: 17-beta-hyd ( 212) 184 49.8 5.8e-06 XP_006720064 (OMIM: 615194) PREDICTED: dehydrogena ( 280) 185 50.1 6.2e-06 NP_005785 (OMIM: 615194) dehydrogenase/reductase S ( 280) 185 50.1 6.2e-06 XP_005267306 (OMIM: 615194) PREDICTED: dehydrogena ( 280) 185 50.1 6.2e-06 NP_057330 (OMIM: 612832) 17-beta-hydroxysteroid de ( 270) 184 49.9 7e-06 NP_000851 (OMIM: 119900,259100,601688) 15-hydroxyp ( 266) 183 49.6 8.1e-06 NP_878912 (OMIM: 615194) dehydrogenase/reductase S ( 300) 182 49.5 1e-05 NP_000405 (OMIM: 233400,261515,601860) peroxisomal ( 736) 185 50.4 1.3e-05 XP_005266734 (OMIM: 136440) PREDICTED: 3-ketodihyd ( 298) 180 49.0 1.4e-05 NP_653284 (OMIM: 616157) dehydrogenase/reductase S ( 377) 180 49.1 1.7e-05 NP_620419 (OMIM: 608989) epidermal retinol dehydro ( 309) 178 48.6 2e-05 NP_001304978 (OMIM: 608989) epidermal retinol dehy ( 318) 178 48.6 2e-05 NP_001243234 (OMIM: 119900,259100,601688) 15-hydro ( 143) 169 46.3 4.3e-05 XP_011530209 (OMIM: 119900,259100,601688) PREDICTE ( 176) 169 46.4 5.1e-05 NP_001139288 (OMIM: 119900,259100,601688) 15-hydro ( 178) 169 46.4 5.1e-05 NP_001317148 (OMIM: 109684) estradiol 17-beta-dehy ( 329) 169 46.6 8.2e-05 NP_932349 (OMIM: 615196) dehydrogenase/reductase S ( 232) 167 46.0 8.5e-05 XP_011523031 (OMIM: 109684) PREDICTED: estradiol 1 ( 384) 169 46.7 9.3e-05 NP_003115 (OMIM: 182125,612716) sepiapterin reduct ( 261) 166 45.9 0.00011 NP_065715 (OMIM: 615839) peroxisomal 2,4-dienoyl-C ( 292) 163 45.2 0.00019 NP_000404 (OMIM: 109684) estradiol 17-beta-dehydro ( 328) 163 45.3 0.00021 NP_057329 (OMIM: 612831) estradiol 17-beta-dehydro ( 300) 162 45.0 0.00022 XP_011523032 (OMIM: 109684) PREDICTED: estradiol 1 ( 383) 163 45.3 0.00023 NP_057226 (OMIM: 609574) very-long-chain 3-oxoacyl ( 312) 161 44.8 0.00027 NP_057113 (OMIM: 612833) dehydrogenase/reductase S ( 339) 161 44.8 0.00029 NP_001239579 (OMIM: 607849,616108) retinol dehydro ( 248) 159 44.3 0.00031 XP_016876857 (OMIM: 612833) PREDICTED: dehydrogena ( 404) 161 44.9 0.00033 NP_001309209 (OMIM: 612833) dehydrogenase/reductas ( 289) 159 44.3 0.00035 NP_001317088 (OMIM: 616160) dehydrogenase/reductas ( 310) 159 44.4 0.00036 XP_016879915 (OMIM: 616160) PREDICTED: dehydrogena ( 325) 159 44.4 0.00038 >>NP_001129522 (OMIM: 610410) dehydrogenase/reductase SD (313 aa) initn: 2085 init1: 2085 opt: 2085 Z-score: 2505.6 bits: 471.8 E(85289): 7.9e-133 Smith-Waterman score: 2085; 99.7% identity (100.0% similar) in 313 aa overlap (1-313:1-313) 10 20 30 40 50 60 pF1KB8 MAAPMNGQVCVVTGASRGIGRGIALQLCKAGATVYITGRHLDTLRVVAQEAQSLGGQCVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAAPMNGQVCVVTGASRGIGRGIALQLCKAGATVYITGRHLDTLRVVAQEAQSLGGQCVP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 VVCDSSQESEVRSLFEQVDREQQGRLDVLVNNAYAGVQTILNTRNKAFWETPASMWDDIN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VVCDSSQESEVRSLFEQVDREQQGRLDVLVNNAYAGVQTILNTRNKAFWETPASMWDDIN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 NVGLRGHYFCSVYGARLMVPAGQGLIVVISSPGSLQYMFNVPYGVGKAACDKLAADCAHE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NVGLRGHYFCSVYGARLMVPAGQGLIVVISSPGSLQYMFNVPYGVGKAACDKLAADCAHE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 LRRHGVSCVSLWPGIVQTELLKEHMAKEEVLQDPVLKQFKSAFSSAETTELSGKCVVALA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LRRHGVSCVSLWPGIVQTELLKEHMAKEEVLQDPVLKQFKSAFSSAETTELSGKCVVALA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 TDPNILSLSGKVLPSCDLARRYGLRDVDGRPVQDYLSLSSVLSHVSGLGWLASYLPSFLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TDPNILSLSGKVLPSCDLARRYGLRDVDGRPVQDYLSLSSVLSHVSGLGWLASYLPSFLR 250 260 270 280 290 300 310 pF1KB8 VPRWIIALYTSKF ::.:::::::::: NP_001 VPKWIIALYTSKF 310 >>NP_612461 (OMIM: 610410) dehydrogenase/reductase SDR f (313 aa) initn: 2085 init1: 2085 opt: 2085 Z-score: 2505.6 bits: 471.8 E(85289): 7.9e-133 Smith-Waterman score: 2085; 99.7% identity (100.0% similar) in 313 aa overlap (1-313:1-313) 10 20 30 40 50 60 pF1KB8 MAAPMNGQVCVVTGASRGIGRGIALQLCKAGATVYITGRHLDTLRVVAQEAQSLGGQCVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_612 MAAPMNGQVCVVTGASRGIGRGIALQLCKAGATVYITGRHLDTLRVVAQEAQSLGGQCVP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 VVCDSSQESEVRSLFEQVDREQQGRLDVLVNNAYAGVQTILNTRNKAFWETPASMWDDIN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_612 VVCDSSQESEVRSLFEQVDREQQGRLDVLVNNAYAGVQTILNTRNKAFWETPASMWDDIN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 NVGLRGHYFCSVYGARLMVPAGQGLIVVISSPGSLQYMFNVPYGVGKAACDKLAADCAHE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_612 NVGLRGHYFCSVYGARLMVPAGQGLIVVISSPGSLQYMFNVPYGVGKAACDKLAADCAHE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 LRRHGVSCVSLWPGIVQTELLKEHMAKEEVLQDPVLKQFKSAFSSAETTELSGKCVVALA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_612 LRRHGVSCVSLWPGIVQTELLKEHMAKEEVLQDPVLKQFKSAFSSAETTELSGKCVVALA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 TDPNILSLSGKVLPSCDLARRYGLRDVDGRPVQDYLSLSSVLSHVSGLGWLASYLPSFLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_612 TDPNILSLSGKVLPSCDLARRYGLRDVDGRPVQDYLSLSSVLSHVSGLGWLASYLPSFLR 250 260 270 280 290 300 310 pF1KB8 VPRWIIALYTSKF ::.:::::::::: NP_612 VPKWIIALYTSKF 310 >>NP_060911 (OMIM: 605843) peroxisomal trans-2-enoyl-CoA (303 aa) initn: 125 init1: 125 opt: 229 Z-score: 279.8 bits: 59.9 E(85289): 7.6e-09 Smith-Waterman score: 229; 27.8% identity (59.9% similar) in 212 aa overlap (3-204:12-212) 10 20 30 40 pF1KB8 MAAP--MNGQVCVVTGASRGIGRGIALQLCKAGATVYITGRHLDTLRVVAQ :: ..::: .:::.. :::..:. .: . :..: :..:.:. :. .:. NP_060 MASWAKGRSYLAPGLLQGQVAIVTGGATGIGKAIVKELLELGSNVVIASRKLERLKSAAD 10 20 30 40 50 60 50 60 70 80 90 100 pF1KB8 EAQ-----SLGGQCVPVVCDSSQESEVRSLFEQVDREQQGRLDVLVNNAYAGVQTILNTR : : . .. .:. :. .: :: .: ... . :... ::::. : : . .. NP_060 ELQANLPPTKQARVIPIQCNIRNEEEVNNLVKST-LDTFGKINFLVNNG--GGQFLSPAE 70 80 90 100 110 110 120 130 140 150 160 pF1KB8 NKAFWETPASMWDDINNVGLRG-HYFCSVYGARLMVPAGQGLIVVISSPGSLQYMFNVPY . . .. : . ...: : :.:.. . : : : :: : : . . . : NP_060 HIS-----SKGWHAVLETNLTGTFYMCKAVYSSWMKEHG-GSIVNIIVPTKAGFPLAVHS 120 130 140 150 160 170 170 180 190 200 210 220 pF1KB8 GVGKAACDKLAADCAHELRRHGV--SCVSLWPGIVQTELLKEHMAKEEVLQDPVLKQFKS :...:. .:. . : : :. .::. ::.. .. :. NP_060 GAARAGVYNLTKSLALEWACSGIRINCVA--PGVIYSQTAVENYGSWGQSFFEGSFQKIP 180 190 200 210 220 230 240 250 260 270 280 pF1KB8 AFSSAETTELSGKCVVALATDPNILSLSGKVLPSCDLARRYGLRDVDGRPVQDYLSLSSV NP_060 AKRIGVPEEVSSVVCFLLSPAASFITGQSVDVDGGRSLYTHSYEVPDHDNWPKGAGDLSV 230 240 250 260 270 280 >>NP_055049 (OMIM: 601417) estradiol 17-beta-dehydrogena (261 aa) initn: 181 init1: 91 opt: 228 Z-score: 279.5 bits: 59.6 E(85289): 7.8e-09 Smith-Waterman score: 228; 29.7% identity (57.5% similar) in 212 aa overlap (5-203:9-209) 10 20 30 40 50 pF1KB8 MAAPMNGQVCVVTGASRGIGRGIALQLCKAGATVYITGRHLDTLRVVAQEA-QSLG . . . .::::. ::::.....: :::: : :..:::. . :: NP_055 MASQLQNRLRSALALVTGAGSGIGRAVSVRLAGEGATVAAC----DLDRAAAQETVRLLG 10 20 30 40 50 60 70 80 90 100 pF1KB8 G----QCVP------VVCDSSQESEVRSLFEQVDREQQGRLDVLVNNAYAGVQTILNTRN : . : : :. .: :.:::. . .:.:. : :. :.. NP_055 GPGSKEGPPRGNHAAFQADVSEARAARCLLEQVQACFSRPPSVVVSCA--GI-----TQD 60 70 80 90 100 110 120 130 140 150 160 pF1KB8 KAFWETPASMWDDINNVGLRGHYFCSVYGARLMVPAG-QGLIVVISSP-GSLQYMFNVPY . . . . :: . :.:.: .. . .:. .: : .: :. ::: :.. . .. : NP_055 EFLLHMSEDDWDKVIAVNLKGTFLVTQAAAQALVSNGCRGSIINISSIVGKVGNVGQTNY 110 120 130 140 150 160 170 180 190 200 210 220 pF1KB8 GVGKAACDKLAADCAHELRRHGVSCVSLWPGIVQTELLKEHMAKEEVLQDPVLKQFKSAF ...::. :. :.:: :::. : :. ::.. : . .. NP_055 AASKAGVIGLTQTAARELGRHGIRCNSVLPGFIATPMTQKVPQKVVDKITEMIPMGHLGD 170 180 190 200 210 220 230 240 250 260 270 280 pF1KB8 SSAETTELSGKCVVALATDPNILSLSGKVLPSCDLARRYGLRDVDGRPVQDYLSLSSVLS NP_055 PEDVADVVAFLASEDSGYITGTSVEVTGGLFM 230 240 250 260 >>NP_077284 (OMIM: 616159) dehydrogenase/reductase SDR f (260 aa) initn: 82 init1: 64 opt: 223 Z-score: 273.6 bits: 58.5 E(85289): 1.7e-08 Smith-Waterman score: 223; 29.2% identity (57.9% similar) in 209 aa overlap (8-204:12-210) 10 20 30 40 50 pF1KB8 MAAPMNGQVCVVTGASRGIGRGIALQLCKAGATVYITGRHLDTLRVVAQEAQSLG- .. .::::: ::: ..: : . : : .: . ... .: : .: : NP_077 MARPGMERWRDRLALVTGASGGIGAAVARALVQQGLKVVGCARTVGNIEELAAECKSAGY 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB8 -GQCVPVVCDSSQESEVRSLFEQVDREQQGRLDVLVNNAYAGVQTILNTRNKAFWETPAS : .: :: :.: .. :.: . : :.. .:. .:: ::. .: .. .: NP_077 PGTLIPYRCDLSNEEDILSMFSAI-RSQHSGVDICINN--AGL-----ARPDTLLSGSTS 70 80 90 100 110 120 130 140 150 160 pF1KB8 MWDDINNVGLRGHYFCS--VYGARLMVPAGQGLIVVISSPGSLQYM-FNVP--YGVGKAA : :. ::.. . .:. .: . . .: :. :.: .. . . ..: :.. : : NP_077 GWKDMFNVNVLALSICTREAYQSMKERNVDDGHIININSMSGHRVLPLSVTHFYSATKYA 120 130 140 150 160 170 170 180 190 200 210 220 pF1KB8 CDKLAADCAHELRR---H-GVSCVSLWPGIVQTEL-LKEHMAKEEVLQDPVLKQFKSAFS :. .:::. : ..:.: ::.:.:.. .: : NP_077 VTALTEGLRQELREAQTHIRATCIS--PGVVETQFAFKLHDKDPEKAAATYEQMKCLKPE 180 190 200 210 220 230 230 240 250 260 270 280 pF1KB8 SAETTELSGKCVVALATDPNILSLSGKVLPSCDLARRYGLRDVDGRPVQDYLSLSSVLSH NP_077 DVAEAVIYVLSTPAHIQIGDIQMRPTEQVT 240 250 260 >>NP_001317504 (OMIM: 222745) 2,4-dienoyl-CoA reductase, (326 aa) initn: 101 init1: 61 opt: 216 Z-score: 263.8 bits: 57.0 E(85289): 5.9e-08 Smith-Waterman score: 216; 24.0% identity (58.7% similar) in 196 aa overlap (7-199:50-237) 10 20 30 pF1KB8 MAAPMNGQVCVVTGASRGIGRGIALQLCKAGATVYI :.: .::.. :.:.:.. : . :: : NP_001 TKILYQNTEALQSKFFSPLQKAMLPPNSFQGKVAFITGGGTGLGKGMTTLLSSLGAQCVI 20 30 40 50 60 70 40 50 60 70 80 90 pF1KB8 TGRHLDTLRVVAQEAQSLGGQCVPVV-CDSSQESEVRSLFEQVDREQQGRLDVLVNNAYA ..:..:.:...:.. .: :. : .. :: . . :.. .. . :. ....::: : NP_001 ASRKMDVLKATAEQISSQTGNKVHAIQCDVRDPDMVQNTVSELIKVA-GHPNIVINNA-A 80 90 100 110 120 130 100 110 120 130 140 150 pF1KB8 GVQTILNTRNKAFWETPASMWDDINNVGLRGHYFCSVYGARLMVPAGQG--LIVVISSPG : : . . .: . : :... : : : .. .. .. : .: .. . . . NP_001 G-----NFISPTERLSPNA-WKTITDIVLNGTAFVTLEIGKQLIKAQKGAAFLSITTIYA 140 150 160 170 180 190 160 170 180 190 200 210 pF1KB8 SLQYMFNVPYGVGKAACDKLAADCAHELRRHGVSCVSLWPGIVQTELLKEHMAKEEVLQD : :: . .::. . .. . : : ..:. . :: ..:. NP_001 ETGSGFVVPSASAKAGVEAMSKSLAAEWGKYGMRFNVIQPGPIKTKGAFSRLDPTGTFEK 200 210 220 230 240 250 220 230 240 250 260 270 pF1KB8 PVLKQFKSAFSSAETTELSGKCVVALATDPNILSLSGKVLPSCDLARRYGLRDVDGRPVQ NP_001 EMIGRIPCGRLGTVEELANLAAFLCSDYASWINGAVIKFDGGEEVLISGEFNDLRKVTKE 260 270 280 290 300 310 >>XP_016868636 (OMIM: 222745) PREDICTED: 2,4-dienoyl-CoA (326 aa) initn: 101 init1: 61 opt: 216 Z-score: 263.8 bits: 57.0 E(85289): 5.9e-08 Smith-Waterman score: 216; 24.0% identity (58.7% similar) in 196 aa overlap (7-199:50-237) 10 20 30 pF1KB8 MAAPMNGQVCVVTGASRGIGRGIALQLCKAGATVYI :.: .::.. :.:.:.. : . :: : XP_016 TKILYQNTEALQSKFFSPLQKAMLPPNSFQGKVAFITGGGTGLGKGMTTLLSSLGAQCVI 20 30 40 50 60 70 40 50 60 70 80 90 pF1KB8 TGRHLDTLRVVAQEAQSLGGQCVPVV-CDSSQESEVRSLFEQVDREQQGRLDVLVNNAYA ..:..:.:...:.. .: :. : .. :: . . :.. .. . :. ....::: : XP_016 ASRKMDVLKATAEQISSQTGNKVHAIQCDVRDPDMVQNTVSELIKVA-GHPNIVINNA-A 80 90 100 110 120 130 100 110 120 130 140 150 pF1KB8 GVQTILNTRNKAFWETPASMWDDINNVGLRGHYFCSVYGARLMVPAGQG--LIVVISSPG : : . . .: . : :... : : : .. .. .. : .: .. . . . XP_016 G-----NFISPTERLSPNA-WKTITDIVLNGTAFVTLEIGKQLIKAQKGAAFLSITTIYA 140 150 160 170 180 190 160 170 180 190 200 210 pF1KB8 SLQYMFNVPYGVGKAACDKLAADCAHELRRHGVSCVSLWPGIVQTELLKEHMAKEEVLQD : :: . .::. . .. . : : ..:. . :: ..:. XP_016 ETGSGFVVPSASAKAGVEAMSKSLAAEWGKYGMRFNVIQPGPIKTKGAFSRLDPTGTFEK 200 210 220 230 240 250 220 230 240 250 260 270 pF1KB8 PVLKQFKSAFSSAETTELSGKCVVALATDPNILSLSGKVLPSCDLARRYGLRDVDGRPVQ XP_016 EMIGRIPCGRLGTVEELANLAAFLCSDYASWINGAVIKFDGGEEVLISGEFNDLRKVTKE 260 270 280 290 300 310 >>XP_011515182 (OMIM: 222745) PREDICTED: 2,4-dienoyl-CoA (326 aa) initn: 101 init1: 61 opt: 216 Z-score: 263.8 bits: 57.0 E(85289): 5.9e-08 Smith-Waterman score: 216; 24.0% identity (58.7% similar) in 196 aa overlap (7-199:50-237) 10 20 30 pF1KB8 MAAPMNGQVCVVTGASRGIGRGIALQLCKAGATVYI :.: .::.. :.:.:.. : . :: : XP_011 TKILYQNTEALQSKFFSPLQKAMLPPNSFQGKVAFITGGGTGLGKGMTTLLSSLGAQCVI 20 30 40 50 60 70 40 50 60 70 80 90 pF1KB8 TGRHLDTLRVVAQEAQSLGGQCVPVV-CDSSQESEVRSLFEQVDREQQGRLDVLVNNAYA ..:..:.:...:.. .: :. : .. :: . . :.. .. . :. ....::: : XP_011 ASRKMDVLKATAEQISSQTGNKVHAIQCDVRDPDMVQNTVSELIKVA-GHPNIVINNA-A 80 90 100 110 120 130 100 110 120 130 140 150 pF1KB8 GVQTILNTRNKAFWETPASMWDDINNVGLRGHYFCSVYGARLMVPAGQG--LIVVISSPG : : . . .: . : :... : : : .. .. .. : .: .. . . . XP_011 G-----NFISPTERLSPNA-WKTITDIVLNGTAFVTLEIGKQLIKAQKGAAFLSITTIYA 140 150 160 170 180 190 160 170 180 190 200 210 pF1KB8 SLQYMFNVPYGVGKAACDKLAADCAHELRRHGVSCVSLWPGIVQTELLKEHMAKEEVLQD : :: . .::. . .. . : : ..:. . :: ..:. XP_011 ETGSGFVVPSASAKAGVEAMSKSLAAEWGKYGMRFNVIQPGPIKTKGAFSRLDPTGTFEK 200 210 220 230 240 250 220 230 240 250 260 270 pF1KB8 PVLKQFKSAFSSAETTELSGKCVVALATDPNILSLSGKVLPSCDLARRYGLRDVDGRPVQ XP_011 EMIGRIPCGRLGTVEELANLAAFLCSDYASWINGAVIKFDGGEEVLISGEFNDLRKVTKE 260 270 280 290 300 310 >>XP_016868637 (OMIM: 222745) PREDICTED: 2,4-dienoyl-CoA (326 aa) initn: 101 init1: 61 opt: 216 Z-score: 263.8 bits: 57.0 E(85289): 5.9e-08 Smith-Waterman score: 216; 24.0% identity (58.7% similar) in 196 aa overlap (7-199:50-237) 10 20 30 pF1KB8 MAAPMNGQVCVVTGASRGIGRGIALQLCKAGATVYI :.: .::.. :.:.:.. : . :: : XP_016 TKILYQNTEALQSKFFSPLQKAMLPPNSFQGKVAFITGGGTGLGKGMTTLLSSLGAQCVI 20 30 40 50 60 70 40 50 60 70 80 90 pF1KB8 TGRHLDTLRVVAQEAQSLGGQCVPVV-CDSSQESEVRSLFEQVDREQQGRLDVLVNNAYA ..:..:.:...:.. .: :. : .. :: . . :.. .. . :. ....::: : XP_016 ASRKMDVLKATAEQISSQTGNKVHAIQCDVRDPDMVQNTVSELIKVA-GHPNIVINNA-A 80 90 100 110 120 130 100 110 120 130 140 150 pF1KB8 GVQTILNTRNKAFWETPASMWDDINNVGLRGHYFCSVYGARLMVPAGQG--LIVVISSPG : : . . .: . : :... : : : .. .. .. : .: .. . . . XP_016 G-----NFISPTERLSPNA-WKTITDIVLNGTAFVTLEIGKQLIKAQKGAAFLSITTIYA 140 150 160 170 180 190 160 170 180 190 200 210 pF1KB8 SLQYMFNVPYGVGKAACDKLAADCAHELRRHGVSCVSLWPGIVQTELLKEHMAKEEVLQD : :: . .::. . .. . : : ..:. . :: ..:. XP_016 ETGSGFVVPSASAKAGVEAMSKSLAAEWGKYGMRFNVIQPGPIKTKGAFSRLDPTGTFEK 200 210 220 230 240 250 220 230 240 250 260 270 pF1KB8 PVLKQFKSAFSSAETTELSGKCVVALATDPNILSLSGKVLPSCDLARRYGLRDVDGRPVQ XP_016 EMIGRIPCGRLGTVEELANLAAFLCSDYASWINGAVIKFDGGEEVLISGEFNDLRKVTKE 260 270 280 290 300 310 >>NP_001350 (OMIM: 222745) 2,4-dienoyl-CoA reductase, mi (335 aa) initn: 101 init1: 61 opt: 216 Z-score: 263.6 bits: 57.0 E(85289): 6e-08 Smith-Waterman score: 216; 24.0% identity (58.7% similar) in 196 aa overlap (7-199:59-246) 10 20 30 pF1KB8 MAAPMNGQVCVVTGASRGIGRGIALQLCKAGATVYI :.: .::.. :.:.:.. : . :: : NP_001 TKILYQNTEALQSKFFSPLQKAMLPPNSFQGKVAFITGGGTGLGKGMTTLLSSLGAQCVI 30 40 50 60 70 80 40 50 60 70 80 90 pF1KB8 TGRHLDTLRVVAQEAQSLGGQCVPVV-CDSSQESEVRSLFEQVDREQQGRLDVLVNNAYA ..:..:.:...:.. .: :. : .. :: . . :.. .. . :. ....::: : NP_001 ASRKMDVLKATAEQISSQTGNKVHAIQCDVRDPDMVQNTVSELIKVA-GHPNIVINNA-A 90 100 110 120 130 140 100 110 120 130 140 150 pF1KB8 GVQTILNTRNKAFWETPASMWDDINNVGLRGHYFCSVYGARLMVPAGQG--LIVVISSPG : : . . .: . : :... : : : .. .. .. : .: .. . . . NP_001 G-----NFISPTERLSPNA-WKTITDIVLNGTAFVTLEIGKQLIKAQKGAAFLSITTIYA 150 160 170 180 190 200 160 170 180 190 200 210 pF1KB8 SLQYMFNVPYGVGKAACDKLAADCAHELRRHGVSCVSLWPGIVQTELLKEHMAKEEVLQD : :: . .::. . .. . : : ..:. . :: ..:. NP_001 ETGSGFVVPSASAKAGVEAMSKSLAAEWGKYGMRFNVIQPGPIKTKGAFSRLDPTGTFEK 210 220 230 240 250 260 220 230 240 250 260 270 pF1KB8 PVLKQFKSAFSSAETTELSGKCVVALATDPNILSLSGKVLPSCDLARRYGLRDVDGRPVQ NP_001 EMIGRIPCGRLGTVEELANLAAFLCSDYASWINGAVIKFDGGEEVLISGEFNDLRKVTKE 270 280 290 300 310 320 313 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 11:51:03 2016 done: Fri Nov 4 11:51:04 2016 Total Scan time: 4.570 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]