FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8348, 479 aa 1>>>pF1KB8348 479 - 479 aa - 479 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.3937+/-0.000339; mu= 9.5276+/- 0.021 mean_var=141.4644+/-28.884, 0's: 0 Z-trim(119.5): 152 B-trim: 1959 in 2/54 Lambda= 0.107833 statistics sampled from 33423 (33577) to 33423 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.738), E-opt: 0.2 (0.394), width: 16 Scan time: 9.720 The best scores are: opt bits E(85289) NP_891548 (OMIM: 165080) transcriptional regulator ( 479) 3340 531.0 2.8e-150 NP_001230357 (OMIM: 165080) transcriptional regula ( 486) 3322 528.2 2e-149 NP_001129626 (OMIM: 165080) transcriptional regula ( 486) 3322 528.2 2e-149 NP_001129627 (OMIM: 165080) transcriptional regula ( 387) 2726 435.4 1.3e-121 NP_001230361 (OMIM: 165080) transcriptional regula ( 317) 2099 337.8 2.6e-92 XP_016883776 (OMIM: 165080) PREDICTED: transcripti ( 459) 1805 292.2 2.1e-78 XP_011527789 (OMIM: 165080) PREDICTED: transcripti ( 259) 1672 271.3 2.2e-72 NP_001278320 (OMIM: 165080) transcriptional regula ( 325) 1672 271.4 2.6e-72 NP_001230358 (OMIM: 165080) transcriptional regula ( 363) 1650 268.0 3.1e-71 XP_016883778 (OMIM: 165080) PREDICTED: transcripti ( 428) 1650 268.1 3.5e-71 XP_011527788 (OMIM: 165080) PREDICTED: transcripti ( 435) 1650 268.1 3.6e-71 NP_001317954 (OMIM: 165080) transcriptional regula ( 455) 1650 268.1 3.7e-71 NP_004440 (OMIM: 165080) transcriptional regulator ( 462) 1650 268.1 3.8e-71 NP_001257939 (OMIM: 193067) Friend leukemia integr ( 386) 1274 209.5 1.3e-53 XP_016872894 (OMIM: 193067) PREDICTED: Friend leuk ( 419) 1274 209.6 1.4e-53 NP_001161153 (OMIM: 193067) Friend leukemia integr ( 419) 1274 209.6 1.4e-53 XP_011541003 (OMIM: 193067) PREDICTED: Friend leuk ( 419) 1274 209.6 1.4e-53 XP_016872895 (OMIM: 193067) PREDICTED: Friend leuk ( 419) 1274 209.6 1.4e-53 NP_002008 (OMIM: 193067) Friend leukemia integrati ( 452) 1274 209.6 1.5e-53 NP_001257941 (OMIM: 193067) Friend leukemia integr ( 259) 1267 208.3 2e-53 XP_011541004 (OMIM: 193067) PREDICTED: Friend leuk ( 410) 1171 193.5 9.2e-49 NP_059991 (OMIM: 607150) protein FEV [Homo sapiens ( 238) 611 106.3 1e-22 NP_001317380 (OMIM: 164720) protein C-ets-1 isofor ( 354) 599 104.5 5e-22 XP_016872806 (OMIM: 164720) PREDICTED: protein C-e ( 398) 599 104.5 5.5e-22 XP_011540953 (OMIM: 164720) PREDICTED: protein C-e ( 432) 599 104.6 5.9e-22 XP_005260992 (OMIM: 164740) PREDICTED: protein C-e ( 469) 453 81.9 4.3e-15 XP_016883779 (OMIM: 164740) PREDICTED: protein C-e ( 469) 453 81.9 4.3e-15 NP_005230 (OMIM: 164740) protein C-ets-2 isoform 1 ( 469) 453 81.9 4.3e-15 NP_001243224 (OMIM: 164740) protein C-ets-2 isofor ( 609) 453 81.9 5.3e-15 NP_001155894 (OMIM: 164720) protein C-ets-1 isofor ( 225) 445 80.4 5.7e-15 XP_016872805 (OMIM: 164720) PREDICTED: protein C-e ( 418) 445 80.6 9.4e-15 NP_005229 (OMIM: 164720) protein C-ets-1 isoform 2 ( 441) 445 80.6 9.8e-15 XP_016872804 (OMIM: 164720) PREDICTED: protein C-e ( 450) 445 80.6 9.9e-15 XP_011540952 (OMIM: 164720) PREDICTED: protein C-e ( 475) 445 80.6 1e-14 NP_001137292 (OMIM: 164720) protein C-ets-1 isofor ( 485) 445 80.6 1.1e-14 XP_016872803 (OMIM: 164720) PREDICTED: protein C-e ( 485) 445 80.6 1.1e-14 XP_011540951 (OMIM: 164720) PREDICTED: protein C-e ( 519) 445 80.7 1.1e-14 XP_016883802 (OMIM: 600609) PREDICTED: GA-binding ( 454) 408 74.9 5.4e-13 XP_011527823 (OMIM: 600609) PREDICTED: GA-binding ( 454) 408 74.9 5.4e-13 XP_011527822 (OMIM: 600609) PREDICTED: GA-binding ( 454) 408 74.9 5.4e-13 NP_002031 (OMIM: 600609) GA-binding protein alpha ( 454) 408 74.9 5.4e-13 XP_005260995 (OMIM: 600609) PREDICTED: GA-binding ( 454) 408 74.9 5.4e-13 NP_001184226 (OMIM: 600609) GA-binding protein alp ( 454) 408 74.9 5.4e-13 NP_006485 (OMIM: 600775,611888) ETS domain-contain ( 548) 407 74.8 7e-13 NP_001156619 (OMIM: 600541) ETS translocation vari ( 454) 405 74.4 7.5e-13 NP_005231 (OMIM: 164873) ETS translocation variant ( 143) 390 71.7 1.5e-12 XP_011524926 (OMIM: 609358) PREDICTED: ETS translo ( 249) 394 72.5 1.5e-12 NP_001287903 (OMIM: 609358) ETS translocation vari ( 249) 394 72.5 1.5e-12 NP_055024 (OMIM: 609358) ETS translocation variant ( 342) 394 72.6 2e-12 XP_016881961 (OMIM: 609358) PREDICTED: ETS translo ( 343) 394 72.6 2e-12 >>NP_891548 (OMIM: 165080) transcriptional regulator ERG (479 aa) initn: 3340 init1: 3340 opt: 3340 Z-score: 2819.1 bits: 531.0 E(85289): 2.8e-150 Smith-Waterman score: 3340; 100.0% identity (100.0% similar) in 479 aa overlap (1-479:1-479) 10 20 30 40 50 60 pF1KB8 MASTIKEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQQDWLSQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_891 MASTIKEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQQDWLSQP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 PARVTIKMECNPSQVNGSRNSPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHMPPPNMTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_891 PARVTIKMECNPSQVNGSRNSPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHMPPPNMTT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 NERRVIVPADPTLWSTDHVRQWLEWAVKEYGLPDVNILLFQNIDGKELCKMTKDDFQRLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_891 NERRVIVPADPTLWSTDHVRQWLEWAVKEYGLPDVNILLFQNIDGKELCKMTKDDFQRLT 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 PSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTGGAAFIFPNTSVYPEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_891 PSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTGGAAFIFPNTSVYPEA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 TQRITTRPDLPYEPPRRSAWTGHGHPTPQSKAAQPSPSTVPKTEDQRPQLDPYQILGPTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_891 TQRITTRPDLPYEPPRRSAWTGHGHPTPQSKAAQPSPSTVPKTEDQRPQLDPYQILGPTS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 SRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKSKPNM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_891 SRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKSKPNM 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 NYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_891 NYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGS 370 380 390 400 410 420 430 440 450 460 470 pF1KB8 YHAHPQKMNFVAPHPPALPVTSSSFFAAPNPYWNSPTGGIYPNTRLPTSHMPSHLGTYY ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_891 YHAHPQKMNFVAPHPPALPVTSSSFFAAPNPYWNSPTGGIYPNTRLPTSHMPSHLGTYY 430 440 450 460 470 >>NP_001230357 (OMIM: 165080) transcriptional regulator (486 aa) initn: 3322 init1: 3322 opt: 3322 Z-score: 2803.8 bits: 528.2 E(85289): 2e-149 Smith-Waterman score: 3322; 99.6% identity (99.8% similar) in 478 aa overlap (2-479:9-486) 10 20 30 40 50 pF1KB8 MASTIKEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQ :. ::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MIQTVPDPAAHIKEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQ 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB8 QDWLSQPPARVTIKMECNPSQVNGSRNSPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QDWLSQPPARVTIKMECNPSQVNGSRNSPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHM 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB8 PPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLPDVNILLFQNIDGKELCKMTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLPDVNILLFQNIDGKELCKMTK 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB8 DDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTGGAAFIFPN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTGGAAFIFPN 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB8 TSVYPEATQRITTRPDLPYEPPRRSAWTGHGHPTPQSKAAQPSPSTVPKTEDQRPQLDPY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TSVYPEATQRITTRPDLPYEPPRRSAWTGHGHPTPQSKAAQPSPSTVPKTEDQRPQLDPY 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB8 QILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGE 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB8 RKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPS 370 380 390 400 410 420 420 430 440 450 460 470 pF1KB8 DLPYMGSYHAHPQKMNFVAPHPPALPVTSSSFFAAPNPYWNSPTGGIYPNTRLPTSHMPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DLPYMGSYHAHPQKMNFVAPHPPALPVTSSSFFAAPNPYWNSPTGGIYPNTRLPTSHMPS 430 440 450 460 470 480 pF1KB8 HLGTYY :::::: NP_001 HLGTYY >>NP_001129626 (OMIM: 165080) transcriptional regulator (486 aa) initn: 3322 init1: 3322 opt: 3322 Z-score: 2803.8 bits: 528.2 E(85289): 2e-149 Smith-Waterman score: 3322; 99.6% identity (99.8% similar) in 478 aa overlap (2-479:9-486) 10 20 30 40 50 pF1KB8 MASTIKEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQ :. ::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MIQTVPDPAAHIKEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQ 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB8 QDWLSQPPARVTIKMECNPSQVNGSRNSPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QDWLSQPPARVTIKMECNPSQVNGSRNSPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHM 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB8 PPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLPDVNILLFQNIDGKELCKMTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLPDVNILLFQNIDGKELCKMTK 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB8 DDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTGGAAFIFPN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTGGAAFIFPN 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB8 TSVYPEATQRITTRPDLPYEPPRRSAWTGHGHPTPQSKAAQPSPSTVPKTEDQRPQLDPY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TSVYPEATQRITTRPDLPYEPPRRSAWTGHGHPTPQSKAAQPSPSTVPKTEDQRPQLDPY 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB8 QILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGE 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB8 RKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPS 370 380 390 400 410 420 420 430 440 450 460 470 pF1KB8 DLPYMGSYHAHPQKMNFVAPHPPALPVTSSSFFAAPNPYWNSPTGGIYPNTRLPTSHMPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DLPYMGSYHAHPQKMNFVAPHPPALPVTSSSFFAAPNPYWNSPTGGIYPNTRLPTSHMPS 430 440 450 460 470 480 pF1KB8 HLGTYY :::::: NP_001 HLGTYY >>NP_001129627 (OMIM: 165080) transcriptional regulator (387 aa) initn: 2726 init1: 2726 opt: 2726 Z-score: 2304.2 bits: 435.4 E(85289): 1.3e-121 Smith-Waterman score: 2726; 100.0% identity (100.0% similar) in 387 aa overlap (93-479:1-387) 70 80 90 100 110 120 pF1KB8 RVTIKMECNPSQVNGSRNSPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHMPPPNMTTNE :::::::::::::::::::::::::::::: NP_001 MVGSPDTVGMNYGSYMEEKHMPPPNMTTNE 10 20 30 130 140 150 160 170 180 pF1KB8 RRVIVPADPTLWSTDHVRQWLEWAVKEYGLPDVNILLFQNIDGKELCKMTKDDFQRLTPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RRVIVPADPTLWSTDHVRQWLEWAVKEYGLPDVNILLFQNIDGKELCKMTKDDFQRLTPS 40 50 60 70 80 90 190 200 210 220 230 240 pF1KB8 YNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTGGAAFIFPNTSVYPEATQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTGGAAFIFPNTSVYPEATQ 100 110 120 130 140 150 250 260 270 280 290 300 pF1KB8 RITTRPDLPYEPPRRSAWTGHGHPTPQSKAAQPSPSTVPKTEDQRPQLDPYQILGPTSSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RITTRPDLPYEPPRRSAWTGHGHPTPQSKAAQPSPSTVPKTEDQRPQLDPYQILGPTSSR 160 170 180 190 200 210 310 320 330 340 350 360 pF1KB8 LANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKSKPNMNY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKSKPNMNY 220 230 240 250 260 270 370 380 390 400 410 420 pF1KB8 DKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYH 280 290 300 310 320 330 430 440 450 460 470 pF1KB8 AHPQKMNFVAPHPPALPVTSSSFFAAPNPYWNSPTGGIYPNTRLPTSHMPSHLGTYY ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AHPQKMNFVAPHPPALPVTSSSFFAAPNPYWNSPTGGIYPNTRLPTSHMPSHLGTYY 340 350 360 370 380 >>NP_001230361 (OMIM: 165080) transcriptional regulator (317 aa) initn: 2098 init1: 2098 opt: 2099 Z-score: 1778.2 bits: 337.8 E(85289): 2.6e-92 Smith-Waterman score: 2099; 98.7% identity (99.0% similar) in 309 aa overlap (2-310:9-317) 10 20 30 40 50 pF1KB8 MASTIKEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQ :. ::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MIQTVPDPAAHIKEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQ 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB8 QDWLSQPPARVTIKMECNPSQVNGSRNSPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QDWLSQPPARVTIKMECNPSQVNGSRNSPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHM 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB8 PPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLPDVNILLFQNIDGKELCKMTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLPDVNILLFQNIDGKELCKMTK 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB8 DDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTGGAAFIFPN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTGGAAFIFPN 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB8 TSVYPEATQRITTRPDLPYEPPRRSAWTGHGHPTPQSKAAQPSPSTVPKTEDQRPQLDPY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TSVYPEATQRITTRPDLPYEPPRRSAWTGHGHPTPQSKAAQPSPSTVPKTEDQRPQLDPY 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB8 QILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGE :::::::::::::: : NP_001 QILGPTSSRLANPGWTQ 310 >>XP_016883776 (OMIM: 165080) PREDICTED: transcriptional (459 aa) initn: 3118 init1: 1801 opt: 1805 Z-score: 1528.7 bits: 292.2 E(85289): 2.1e-78 Smith-Waterman score: 3067; 93.7% identity (93.9% similar) in 478 aa overlap (2-479:9-459) 10 20 30 40 50 pF1KB8 MASTIKEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQ :. ::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MIQTVPDPAAHIKEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQ 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB8 QDWLSQPPARVTIKMECNPSQVNGSRNSPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QDWLSQPPARVTIKMECNPSQVNGSRNSPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHM 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB8 PPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLPDVNILLFQNIDGKELCKMTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLPDVNILLFQNIDGKELCKMTK 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB8 DDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTGGAAFIFPN :::::::::::::::::::::::: :::::::: XP_016 DDFQRLTPSYNADILLSHLHYLRER---------------------------GAAFIFPN 190 200 210 240 250 260 270 280 290 pF1KB8 TSVYPEATQRITTRPDLPYEPPRRSAWTGHGHPTPQSKAAQPSPSTVPKTEDQRPQLDPY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TSVYPEATQRITTRPDLPYEPPRRSAWTGHGHPTPQSKAAQPSPSTVPKTEDQRPQLDPY 220 230 240 250 260 270 300 310 320 330 340 350 pF1KB8 QILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGE 280 290 300 310 320 330 360 370 380 390 400 410 pF1KB8 RKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPS 340 350 360 370 380 390 420 430 440 450 460 470 pF1KB8 DLPYMGSYHAHPQKMNFVAPHPPALPVTSSSFFAAPNPYWNSPTGGIYPNTRLPTSHMPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DLPYMGSYHAHPQKMNFVAPHPPALPVTSSSFFAAPNPYWNSPTGGIYPNTRLPTSHMPS 400 410 420 430 440 450 pF1KB8 HLGTYY :::::: XP_016 HLGTYY >>XP_011527789 (OMIM: 165080) PREDICTED: transcriptional (259 aa) initn: 1672 init1: 1672 opt: 1672 Z-score: 1420.5 bits: 271.3 E(85289): 2.2e-72 Smith-Waterman score: 1672; 99.2% identity (99.6% similar) in 247 aa overlap (2-248:9-255) 10 20 30 40 50 pF1KB8 MASTIKEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQ :. ::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MIQTVPDPAAHIKEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQ 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB8 QDWLSQPPARVTIKMECNPSQVNGSRNSPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QDWLSQPPARVTIKMECNPSQVNGSRNSPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHM 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB8 PPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLPDVNILLFQNIDGKELCKMTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLPDVNILLFQNIDGKELCKMTK 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB8 DDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTGGAAFIFPN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTGGAAFIFPN 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB8 TSVYPEATQRITTRPDLPYEPPRRSAWTGHGHPTPQSKAAQPSPSTVPKTEDQRPQLDPY ::::::::::::::: XP_011 TSVYPEATQRITTRPVSYR 250 >>NP_001278320 (OMIM: 165080) transcriptional regulator (325 aa) initn: 1672 init1: 1672 opt: 1672 Z-score: 1419.1 bits: 271.4 E(85289): 2.6e-72 Smith-Waterman score: 1672; 99.2% identity (99.6% similar) in 247 aa overlap (2-248:9-255) 10 20 30 40 50 pF1KB8 MASTIKEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQ :. ::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MIQTVPDPAAHIKEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQ 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB8 QDWLSQPPARVTIKMECNPSQVNGSRNSPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QDWLSQPPARVTIKMECNPSQVNGSRNSPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHM 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB8 PPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLPDVNILLFQNIDGKELCKMTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLPDVNILLFQNIDGKELCKMTK 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB8 DDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTGGAAFIFPN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTGGAAFIFPN 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB8 TSVYPEATQRITTRPDLPYEPPRRSAWTGHGHPTPQSKAAQPSPSTVPKTEDQRPQLDPY ::::::::::::::: NP_001 TSVYPEATQRITTRPGTKTPLCDLFIERHPRCPAEIRALSHVIQRELIPELKPVPDSLIL 250 260 270 280 290 300 >>NP_001230358 (OMIM: 165080) transcriptional regulator (363 aa) initn: 2553 init1: 1650 opt: 1650 Z-score: 1399.9 bits: 268.0 E(85289): 3.1e-71 Smith-Waterman score: 2509; 93.8% identity (93.8% similar) in 387 aa overlap (93-479:1-363) 70 80 90 100 110 120 pF1KB8 RVTIKMECNPSQVNGSRNSPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHMPPPNMTTNE :::::::::::::::::::::::::::::: NP_001 MVGSPDTVGMNYGSYMEEKHMPPPNMTTNE 10 20 30 130 140 150 160 170 180 pF1KB8 RRVIVPADPTLWSTDHVRQWLEWAVKEYGLPDVNILLFQNIDGKELCKMTKDDFQRLTPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RRVIVPADPTLWSTDHVRQWLEWAVKEYGLPDVNILLFQNIDGKELCKMTKDDFQRLTPS 40 50 60 70 80 90 190 200 210 220 230 240 pF1KB8 YNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTGGAAFIFPNTSVYPEATQ :::::::::::::::::::::::::::::::::::::::::: NP_001 YNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNT------------------ 100 110 120 130 250 260 270 280 290 300 pF1KB8 RITTRPDLPYEPPRRSAWTGHGHPTPQSKAAQPSPSTVPKTEDQRPQLDPYQILGPTSSR :::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ------DLPYEPPRRSAWTGHGHPTPQSKAAQPSPSTVPKTEDQRPQLDPYQILGPTSSR 140 150 160 170 180 310 320 330 340 350 360 pF1KB8 LANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKSKPNMNY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKSKPNMNY 190 200 210 220 230 240 370 380 390 400 410 420 pF1KB8 DKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYH 250 260 270 280 290 300 430 440 450 460 470 pF1KB8 AHPQKMNFVAPHPPALPVTSSSFFAAPNPYWNSPTGGIYPNTRLPTSHMPSHLGTYY ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AHPQKMNFVAPHPPALPVTSSSFFAAPNPYWNSPTGGIYPNTRLPTSHMPSHLGTYY 310 320 330 340 350 360 >>XP_016883778 (OMIM: 165080) PREDICTED: transcriptional (428 aa) initn: 1650 init1: 1650 opt: 1650 Z-score: 1398.9 bits: 268.1 E(85289): 3.5e-71 Smith-Waterman score: 2881; 89.1% identity (89.4% similar) in 479 aa overlap (1-479:1-428) 10 20 30 40 50 60 pF1KB8 MASTIKEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQQDWLSQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MASTIKEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQQDWLSQP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 PARVTIKMECNPSQVNGSRNSPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHMPPPNMTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PARVTIKMECNPSQVNGSRNSPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHMPPPNMTT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 NERRVIVPADPTLWSTDHVRQWLEWAVKEYGLPDVNILLFQNIDGKELCKMTKDDFQRLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NERRVIVPADPTLWSTDHVRQWLEWAVKEYGLPDVNILLFQNIDGKELCKMTKDDFQRLT 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 PSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTGGAAFIFPNTSVYPEA ::::::::::::::::: XP_016 PSYNADILLSHLHYLRE------------------------------------------- 190 250 260 270 280 290 300 pF1KB8 TQRITTRPDLPYEPPRRSAWTGHGHPTPQSKAAQPSPSTVPKTEDQRPQLDPYQILGPTS .::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 --------NLPYEPPRRSAWTGHGHPTPQSKAAQPSPSTVPKTEDQRPQLDPYQILGPTS 200 210 220 230 240 310 320 330 340 350 360 pF1KB8 SRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKSKPNM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKSKPNM 250 260 270 280 290 300 370 380 390 400 410 420 pF1KB8 NYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGS 310 320 330 340 350 360 430 440 450 460 470 pF1KB8 YHAHPQKMNFVAPHPPALPVTSSSFFAAPNPYWNSPTGGIYPNTRLPTSHMPSHLGTYY ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YHAHPQKMNFVAPHPPALPVTSSSFFAAPNPYWNSPTGGIYPNTRLPTSHMPSHLGTYY 370 380 390 400 410 420 479 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 02:10:57 2016 done: Sat Nov 5 02:10:59 2016 Total Scan time: 9.720 Total Display time: 0.070 Function used was FASTA [36.3.4 Apr, 2011]