FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8353, 347 aa 1>>>pF1KB8353 347 - 347 aa - 347 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.0991+/-0.000353; mu= 17.1595+/- 0.022 mean_var=64.2169+/-12.745, 0's: 0 Z-trim(114.2): 60 B-trim: 213 in 1/55 Lambda= 0.160048 statistics sampled from 23881 (23943) to 23881 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.656), E-opt: 0.2 (0.281), width: 16 Scan time: 6.090 The best scores are: opt bits E(85289) NP_079103 (OMIM: 607226) histone deacetylase 11 is ( 347) 2316 543.5 2.6e-154 XP_011532433 (OMIM: 607226) PREDICTED: histone dea ( 319) 2116 497.3 1.9e-140 XP_005265548 (OMIM: 607226) PREDICTED: histone dea ( 319) 2116 497.3 1.9e-140 NP_001129513 (OMIM: 607226) histone deacetylase 11 ( 296) 1605 379.2 6e-105 XP_011532437 (OMIM: 607226) PREDICTED: histone dea ( 225) 1507 356.5 3.1e-98 XP_011532434 (OMIM: 607226) PREDICTED: histone dea ( 240) 1224 291.2 1.5e-78 NP_001317565 (OMIM: 607226) histone deacetylase 11 ( 268) 1224 291.2 1.7e-78 XP_006713401 (OMIM: 607226) PREDICTED: histone dea ( 268) 908 218.3 1.5e-56 XP_016862723 (OMIM: 607226) PREDICTED: histone dea ( 240) 845 203.7 3.4e-52 NP_001518 (OMIM: 605164) histone deacetylase 2 [Ho ( 488) 305 79.2 2.1e-14 XP_011534090 (OMIM: 605164) PREDICTED: histone dea ( 458) 298 77.6 6e-14 XP_016866288 (OMIM: 605164) PREDICTED: histone dea ( 458) 298 77.6 6e-14 NP_004955 (OMIM: 601241) histone deacetylase 1 [Ho ( 482) 292 76.2 1.6e-13 NP_060956 (OMIM: 300269) histone deacetylase 8 iso ( 377) 278 72.9 1.3e-12 XP_011529289 (OMIM: 300269) PREDICTED: histone dea ( 379) 278 72.9 1.3e-12 XP_011529288 (OMIM: 300269) PREDICTED: histone dea ( 441) 278 72.9 1.4e-12 XP_016885135 (OMIM: 300269) PREDICTED: histone dea ( 274) 247 65.7 1.4e-10 NP_003874 (OMIM: 605166) histone deacetylase 3 [Ho ( 428) 241 64.4 5.2e-10 NP_001159891 (OMIM: 300269) histone deacetylase 8 ( 256) 192 52.9 8.7e-07 NP_001152758 (OMIM: 608544) histone deacetylase 10 ( 649) 194 53.7 1.4e-06 NP_114408 (OMIM: 608544) histone deacetylase 10 is ( 669) 194 53.7 1.4e-06 XP_016885136 (OMIM: 300269) PREDICTED: histone dea ( 268) 175 49.0 1.4e-05 XP_016885130 (OMIM: 300269) PREDICTED: histone dea ( 389) 175 49.1 1.9e-05 XP_016885129 (OMIM: 300269) PREDICTED: histone dea ( 415) 175 49.1 2e-05 NP_001159890 (OMIM: 300269) histone deacetylase 8 ( 286) 157 44.9 0.00026 XP_016885131 (OMIM: 300269) PREDICTED: histone dea ( 350) 157 44.9 0.00031 NP_478056 (OMIM: 606543) histone deacetylase 9 iso (1011) 162 46.4 0.00033 NP_001308826 (OMIM: 606543) histone deacetylase 9 (1025) 162 46.4 0.00033 XP_016868317 (OMIM: 606543) PREDICTED: histone dea (1025) 162 46.4 0.00033 NP_001308806 (OMIM: 606543) histone deacetylase 9 (1025) 162 46.4 0.00033 XP_011513948 (OMIM: 606543) PREDICTED: histone dea (1035) 162 46.4 0.00033 XP_011513946 (OMIM: 606543) PREDICTED: histone dea (1038) 162 46.4 0.00033 XP_011513947 (OMIM: 606543) PREDICTED: histone dea (1038) 162 46.4 0.00033 XP_016868316 (OMIM: 606543) PREDICTED: histone dea (1043) 162 46.4 0.00033 XP_011513943 (OMIM: 606543) PREDICTED: histone dea (1043) 162 46.4 0.00033 XP_011513944 (OMIM: 606543) PREDICTED: histone dea (1043) 162 46.4 0.00033 XP_011513936 (OMIM: 606543) PREDICTED: histone dea (1044) 162 46.4 0.00033 NP_001308797 (OMIM: 606543) histone deacetylase 9 (1044) 162 46.4 0.00033 NP_848510 (OMIM: 606543) histone deacetylase 9 iso (1066) 162 46.4 0.00034 XP_016868315 (OMIM: 606543) PREDICTED: histone dea (1066) 162 46.4 0.00034 XP_011513940 (OMIM: 606543) PREDICTED: histone dea (1069) 162 46.4 0.00034 XP_011513941 (OMIM: 606543) PREDICTED: histone dea (1069) 162 46.4 0.00034 NP_848512 (OMIM: 606543) histone deacetylase 9 iso (1069) 162 46.4 0.00034 XP_011513939 (OMIM: 606543) PREDICTED: histone dea (1071) 162 46.4 0.00034 XP_011513938 (OMIM: 606543) PREDICTED: histone dea (1071) 162 46.4 0.00034 XP_011513937 (OMIM: 606543) PREDICTED: histone dea (1074) 162 46.4 0.00034 XP_011513950 (OMIM: 606543) PREDICTED: histone dea (1074) 162 46.4 0.00034 XP_011513951 (OMIM: 606543) PREDICTED: histone dea (1074) 162 46.4 0.00034 XP_011513931 (OMIM: 606543) PREDICTED: histone dea (1088) 162 46.4 0.00035 XP_011513933 (OMIM: 606543) PREDICTED: histone dea (1096) 162 46.4 0.00035 >>NP_079103 (OMIM: 607226) histone deacetylase 11 isofor (347 aa) initn: 2316 init1: 2316 opt: 2316 Z-score: 2891.4 bits: 543.5 E(85289): 2.6e-154 Smith-Waterman score: 2316; 100.0% identity (100.0% similar) in 347 aa overlap (1-347:1-347) 10 20 30 40 50 60 pF1KB8 MLHTTQLYQHVPETRWPIVYSPRYNITFMGLEKLHPFDAGKWGKVINFLKEEKLLSDSML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 MLHTTQLYQHVPETRWPIVYSPRYNITFMGLEKLHPFDAGKWGKVINFLKEEKLLSDSML 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 VEAREASEEDLLVVHTRRYLNELKWSFAVATITEIPPVIFLPNFLVQRKVLRPLRTQTGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 VEAREASEEDLLVVHTRRYLNELKWSFAVATITEIPPVIFLPNFLVQRKVLRPLRTQTGG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 TIMAGKLAVERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 TIMAGKLAVERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 DAHQGNGHERDFMDDKRVYIMDVYNRHIYPGDRFAKQAIRRKVELEWGTEDDEYLDKVER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 DAHQGNGHERDFMDDKRVYIMDVYNRHIYPGDRFAKQAIRRKVELEWGTEDDEYLDKVER 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 NIKKSLQEHLPDVVVYNAGTDILEGDRLGGLSISPAGIVKRDELVFRMVRGRRVPILMVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 NIKKSLQEHLPDVVVYNAGTDILEGDRLGGLSISPAGIVKRDELVFRMVRGRRVPILMVT 250 260 270 280 290 300 310 320 330 340 pF1KB8 SGGYQKRTARIIADSILNLFGLGLIGPESPSVSAQNSDTPLLPPAVP ::::::::::::::::::::::::::::::::::::::::::::::: NP_079 SGGYQKRTARIIADSILNLFGLGLIGPESPSVSAQNSDTPLLPPAVP 310 320 330 340 >>XP_011532433 (OMIM: 607226) PREDICTED: histone deacety (319 aa) initn: 2116 init1: 2116 opt: 2116 Z-score: 2642.3 bits: 497.3 E(85289): 1.9e-140 Smith-Waterman score: 2116; 100.0% identity (100.0% similar) in 319 aa overlap (29-347:1-319) 10 20 30 40 50 60 pF1KB8 MLHTTQLYQHVPETRWPIVYSPRYNITFMGLEKLHPFDAGKWGKVINFLKEEKLLSDSML :::::::::::::::::::::::::::::::: XP_011 MGLEKLHPFDAGKWGKVINFLKEEKLLSDSML 10 20 30 70 80 90 100 110 120 pF1KB8 VEAREASEEDLLVVHTRRYLNELKWSFAVATITEIPPVIFLPNFLVQRKVLRPLRTQTGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VEAREASEEDLLVVHTRRYLNELKWSFAVATITEIPPVIFLPNFLVQRKVLRPLRTQTGG 40 50 60 70 80 90 130 140 150 160 170 180 pF1KB8 TIMAGKLAVERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TIMAGKLAVERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDL 100 110 120 130 140 150 190 200 210 220 230 240 pF1KB8 DAHQGNGHERDFMDDKRVYIMDVYNRHIYPGDRFAKQAIRRKVELEWGTEDDEYLDKVER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DAHQGNGHERDFMDDKRVYIMDVYNRHIYPGDRFAKQAIRRKVELEWGTEDDEYLDKVER 160 170 180 190 200 210 250 260 270 280 290 300 pF1KB8 NIKKSLQEHLPDVVVYNAGTDILEGDRLGGLSISPAGIVKRDELVFRMVRGRRVPILMVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NIKKSLQEHLPDVVVYNAGTDILEGDRLGGLSISPAGIVKRDELVFRMVRGRRVPILMVT 220 230 240 250 260 270 310 320 330 340 pF1KB8 SGGYQKRTARIIADSILNLFGLGLIGPESPSVSAQNSDTPLLPPAVP ::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SGGYQKRTARIIADSILNLFGLGLIGPESPSVSAQNSDTPLLPPAVP 280 290 300 310 >>XP_005265548 (OMIM: 607226) PREDICTED: histone deacety (319 aa) initn: 2116 init1: 2116 opt: 2116 Z-score: 2642.3 bits: 497.3 E(85289): 1.9e-140 Smith-Waterman score: 2116; 100.0% identity (100.0% similar) in 319 aa overlap (29-347:1-319) 10 20 30 40 50 60 pF1KB8 MLHTTQLYQHVPETRWPIVYSPRYNITFMGLEKLHPFDAGKWGKVINFLKEEKLLSDSML :::::::::::::::::::::::::::::::: XP_005 MGLEKLHPFDAGKWGKVINFLKEEKLLSDSML 10 20 30 70 80 90 100 110 120 pF1KB8 VEAREASEEDLLVVHTRRYLNELKWSFAVATITEIPPVIFLPNFLVQRKVLRPLRTQTGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VEAREASEEDLLVVHTRRYLNELKWSFAVATITEIPPVIFLPNFLVQRKVLRPLRTQTGG 40 50 60 70 80 90 130 140 150 160 170 180 pF1KB8 TIMAGKLAVERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TIMAGKLAVERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDL 100 110 120 130 140 150 190 200 210 220 230 240 pF1KB8 DAHQGNGHERDFMDDKRVYIMDVYNRHIYPGDRFAKQAIRRKVELEWGTEDDEYLDKVER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DAHQGNGHERDFMDDKRVYIMDVYNRHIYPGDRFAKQAIRRKVELEWGTEDDEYLDKVER 160 170 180 190 200 210 250 260 270 280 290 300 pF1KB8 NIKKSLQEHLPDVVVYNAGTDILEGDRLGGLSISPAGIVKRDELVFRMVRGRRVPILMVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NIKKSLQEHLPDVVVYNAGTDILEGDRLGGLSISPAGIVKRDELVFRMVRGRRVPILMVT 220 230 240 250 260 270 310 320 330 340 pF1KB8 SGGYQKRTARIIADSILNLFGLGLIGPESPSVSAQNSDTPLLPPAVP ::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SGGYQKRTARIIADSILNLFGLGLIGPESPSVSAQNSDTPLLPPAVP 280 290 300 310 >>NP_001129513 (OMIM: 607226) histone deacetylase 11 iso (296 aa) initn: 1605 init1: 1605 opt: 1605 Z-score: 2005.1 bits: 379.2 E(85289): 6e-105 Smith-Waterman score: 1906; 92.8% identity (92.8% similar) in 319 aa overlap (29-347:1-296) 10 20 30 40 50 60 pF1KB8 MLHTTQLYQHVPETRWPIVYSPRYNITFMGLEKLHPFDAGKWGKVINFLKEEKLLSDSML :::::::::::::::::::::::::::::::: NP_001 MGLEKLHPFDAGKWGKVINFLKEEKLLSDSML 10 20 30 70 80 90 100 110 120 pF1KB8 VEAREASEEDLLVVHTRRYLNELKWSFAVATITEIPPVIFLPNFLVQRKVLRPLRTQTGG :::::::::::::::::::::::: ::::::::::::: NP_001 VEAREASEEDLLVVHTRRYLNELK-----------------------RKVLRPLRTQTGG 40 50 60 130 140 150 160 170 180 pF1KB8 TIMAGKLAVERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TIMAGKLAVERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDL 70 80 90 100 110 120 190 200 210 220 230 240 pF1KB8 DAHQGNGHERDFMDDKRVYIMDVYNRHIYPGDRFAKQAIRRKVELEWGTEDDEYLDKVER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DAHQGNGHERDFMDDKRVYIMDVYNRHIYPGDRFAKQAIRRKVELEWGTEDDEYLDKVER 130 140 150 160 170 180 250 260 270 280 290 300 pF1KB8 NIKKSLQEHLPDVVVYNAGTDILEGDRLGGLSISPAGIVKRDELVFRMVRGRRVPILMVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NIKKSLQEHLPDVVVYNAGTDILEGDRLGGLSISPAGIVKRDELVFRMVRGRRVPILMVT 190 200 210 220 230 240 310 320 330 340 pF1KB8 SGGYQKRTARIIADSILNLFGLGLIGPESPSVSAQNSDTPLLPPAVP ::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SGGYQKRTARIIADSILNLFGLGLIGPESPSVSAQNSDTPLLPPAVP 250 260 270 280 290 >>XP_011532437 (OMIM: 607226) PREDICTED: histone deacety (225 aa) initn: 1507 init1: 1507 opt: 1507 Z-score: 1884.6 bits: 356.5 E(85289): 3.1e-98 Smith-Waterman score: 1507; 100.0% identity (100.0% similar) in 225 aa overlap (123-347:1-225) 100 110 120 130 140 150 pF1KB8 TEIPPVIFLPNFLVQRKVLRPLRTQTGGTIMAGKLAVERGWAINVGGGFHHCSSDRGGGF :::::::::::::::::::::::::::::: XP_011 MAGKLAVERGWAINVGGGFHHCSSDRGGGF 10 20 30 160 170 180 190 200 210 pF1KB8 CAYADITLAIKFLFERVEGISRATIIDLDAHQGNGHERDFMDDKRVYIMDVYNRHIYPGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CAYADITLAIKFLFERVEGISRATIIDLDAHQGNGHERDFMDDKRVYIMDVYNRHIYPGD 40 50 60 70 80 90 220 230 240 250 260 270 pF1KB8 RFAKQAIRRKVELEWGTEDDEYLDKVERNIKKSLQEHLPDVVVYNAGTDILEGDRLGGLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RFAKQAIRRKVELEWGTEDDEYLDKVERNIKKSLQEHLPDVVVYNAGTDILEGDRLGGLS 100 110 120 130 140 150 280 290 300 310 320 330 pF1KB8 ISPAGIVKRDELVFRMVRGRRVPILMVTSGGYQKRTARIIADSILNLFGLGLIGPESPSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ISPAGIVKRDELVFRMVRGRRVPILMVTSGGYQKRTARIIADSILNLFGLGLIGPESPSV 160 170 180 190 200 210 340 pF1KB8 SAQNSDTPLLPPAVP ::::::::::::::: XP_011 SAQNSDTPLLPPAVP 220 >>XP_011532434 (OMIM: 607226) PREDICTED: histone deacety (240 aa) initn: 1224 init1: 1224 opt: 1224 Z-score: 1531.0 bits: 291.2 E(85289): 1.5e-78 Smith-Waterman score: 1408; 75.2% identity (75.2% similar) in 319 aa overlap (29-347:1-240) 10 20 30 40 50 60 pF1KB8 MLHTTQLYQHVPETRWPIVYSPRYNITFMGLEKLHPFDAGKWGKVINFLKEEKLLSDSML :::::::::::::::::::::::::::::::: XP_011 MGLEKLHPFDAGKWGKVINFLKEEKLLSDSML 10 20 30 70 80 90 100 110 120 pF1KB8 VEAREASEEDLLVVHTRRYLNELKWSFAVATITEIPPVIFLPNFLVQRKVLRPLRTQTGG :::::::::::::::::::::::: XP_011 VEAREASEEDLLVVHTRRYLNELK------------------------------------ 40 50 130 140 150 160 170 180 pF1KB8 TIMAGKLAVERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDL ::::::::::::::::: XP_011 -------------------------------------------FLFERVEGISRATIIDL 60 70 190 200 210 220 230 240 pF1KB8 DAHQGNGHERDFMDDKRVYIMDVYNRHIYPGDRFAKQAIRRKVELEWGTEDDEYLDKVER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DAHQGNGHERDFMDDKRVYIMDVYNRHIYPGDRFAKQAIRRKVELEWGTEDDEYLDKVER 80 90 100 110 120 130 250 260 270 280 290 300 pF1KB8 NIKKSLQEHLPDVVVYNAGTDILEGDRLGGLSISPAGIVKRDELVFRMVRGRRVPILMVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NIKKSLQEHLPDVVVYNAGTDILEGDRLGGLSISPAGIVKRDELVFRMVRGRRVPILMVT 140 150 160 170 180 190 310 320 330 340 pF1KB8 SGGYQKRTARIIADSILNLFGLGLIGPESPSVSAQNSDTPLLPPAVP ::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SGGYQKRTARIIADSILNLFGLGLIGPESPSVSAQNSDTPLLPPAVP 200 210 220 230 240 >>NP_001317565 (OMIM: 607226) histone deacetylase 11 iso (268 aa) initn: 1224 init1: 1224 opt: 1224 Z-score: 1530.3 bits: 291.2 E(85289): 1.7e-78 Smith-Waterman score: 1608; 77.2% identity (77.2% similar) in 347 aa overlap (1-347:1-268) 10 20 30 40 50 60 pF1KB8 MLHTTQLYQHVPETRWPIVYSPRYNITFMGLEKLHPFDAGKWGKVINFLKEEKLLSDSML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MLHTTQLYQHVPETRWPIVYSPRYNITFMGLEKLHPFDAGKWGKVINFLKEEKLLSDSML 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 VEAREASEEDLLVVHTRRYLNELKWSFAVATITEIPPVIFLPNFLVQRKVLRPLRTQTGG :::::::::::::::::::::::: NP_001 VEAREASEEDLLVVHTRRYLNELK------------------------------------ 70 80 130 140 150 160 170 180 pF1KB8 TIMAGKLAVERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDL ::::::::::::::::: NP_001 -------------------------------------------FLFERVEGISRATIIDL 90 100 190 200 210 220 230 240 pF1KB8 DAHQGNGHERDFMDDKRVYIMDVYNRHIYPGDRFAKQAIRRKVELEWGTEDDEYLDKVER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DAHQGNGHERDFMDDKRVYIMDVYNRHIYPGDRFAKQAIRRKVELEWGTEDDEYLDKVER 110 120 130 140 150 160 250 260 270 280 290 300 pF1KB8 NIKKSLQEHLPDVVVYNAGTDILEGDRLGGLSISPAGIVKRDELVFRMVRGRRVPILMVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NIKKSLQEHLPDVVVYNAGTDILEGDRLGGLSISPAGIVKRDELVFRMVRGRRVPILMVT 170 180 190 200 210 220 310 320 330 340 pF1KB8 SGGYQKRTARIIADSILNLFGLGLIGPESPSVSAQNSDTPLLPPAVP ::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SGGYQKRTARIIADSILNLFGLGLIGPESPSVSAQNSDTPLLPPAVP 230 240 250 260 >>XP_006713401 (OMIM: 607226) PREDICTED: histone deacety (268 aa) initn: 1739 init1: 908 opt: 908 Z-score: 1136.0 bits: 218.3 E(85289): 1.5e-56 Smith-Waterman score: 1585; 76.9% identity (77.2% similar) in 347 aa overlap (1-347:1-268) 10 20 30 40 50 60 pF1KB8 MLHTTQLYQHVPETRWPIVYSPRYNITFMGLEKLHPFDAGKWGKVINFLKEEKLLSDSML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MLHTTQLYQHVPETRWPIVYSPRYNITFMGLEKLHPFDAGKWGKVINFLKEEKLLSDSML 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 VEAREASEEDLLVVHTRRYLNELKWSFAVATITEIPPVIFLPNFLVQRKVLRPLRTQTGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VEAREASEEDLLVVHTRRYLNELKWSFAVATITEIPPVIFLPNFLVQRKVLRPLRTQTGG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 TIMAGKLAVERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDL ::::::::::::::::: XP_006 TIMAGKLAVERGWAINV------------------------------------------- 130 190 200 210 220 230 240 pF1KB8 DAHQGNGHERDFMDDKRVYIMDVYNRHIYPGDRFAKQAIRRKVELEWGTEDDEYLDKVER .::::::::::::::::::::::: XP_006 ------------------------------------EAIRRKVELEWGTEDDEYLDKVER 140 150 160 250 260 270 280 290 300 pF1KB8 NIKKSLQEHLPDVVVYNAGTDILEGDRLGGLSISPAGIVKRDELVFRMVRGRRVPILMVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 NIKKSLQEHLPDVVVYNAGTDILEGDRLGGLSISPAGIVKRDELVFRMVRGRRVPILMVT 170 180 190 200 210 220 310 320 330 340 pF1KB8 SGGYQKRTARIIADSILNLFGLGLIGPESPSVSAQNSDTPLLPPAVP ::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SGGYQKRTARIIADSILNLFGLGLIGPESPSVSAQNSDTPLLPPAVP 230 240 250 260 >>XP_016862723 (OMIM: 607226) PREDICTED: histone deacety (240 aa) initn: 1539 init1: 845 opt: 845 Z-score: 1058.1 bits: 203.7 E(85289): 3.4e-52 Smith-Waterman score: 1385; 74.9% identity (75.2% similar) in 319 aa overlap (29-347:1-240) 10 20 30 40 50 60 pF1KB8 MLHTTQLYQHVPETRWPIVYSPRYNITFMGLEKLHPFDAGKWGKVINFLKEEKLLSDSML :::::::::::::::::::::::::::::::: XP_016 MGLEKLHPFDAGKWGKVINFLKEEKLLSDSML 10 20 30 70 80 90 100 110 120 pF1KB8 VEAREASEEDLLVVHTRRYLNELKWSFAVATITEIPPVIFLPNFLVQRKVLRPLRTQTGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VEAREASEEDLLVVHTRRYLNELKWSFAVATITEIPPVIFLPNFLVQRKVLRPLRTQTGG 40 50 60 70 80 90 130 140 150 160 170 180 pF1KB8 TIMAGKLAVERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDL ::::::::::::::::: XP_016 TIMAGKLAVERGWAINV------------------------------------------- 100 190 200 210 220 230 240 pF1KB8 DAHQGNGHERDFMDDKRVYIMDVYNRHIYPGDRFAKQAIRRKVELEWGTEDDEYLDKVER .::::::::::::::::::::::: XP_016 ------------------------------------EAIRRKVELEWGTEDDEYLDKVER 110 120 130 250 260 270 280 290 300 pF1KB8 NIKKSLQEHLPDVVVYNAGTDILEGDRLGGLSISPAGIVKRDELVFRMVRGRRVPILMVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NIKKSLQEHLPDVVVYNAGTDILEGDRLGGLSISPAGIVKRDELVFRMVRGRRVPILMVT 140 150 160 170 180 190 310 320 330 340 pF1KB8 SGGYQKRTARIIADSILNLFGLGLIGPESPSVSAQNSDTPLLPPAVP ::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SGGYQKRTARIIADSILNLFGLGLIGPESPSVSAQNSDTPLLPPAVP 200 210 220 230 240 >>NP_001518 (OMIM: 605164) histone deacetylase 2 [Homo s (488 aa) initn: 200 init1: 103 opt: 305 Z-score: 379.7 bits: 79.2 E(85289): 2.1e-14 Smith-Waterman score: 305; 27.4% identity (56.9% similar) in 288 aa overlap (35-307:29-307) 10 20 30 40 50 60 pF1KB8 TQLYQHVPETRWPIVYSPRYNITFMGLEKLHPFDAGKWGKVINFLKEEKLLSDSMLVEAR ::. . . :.: . : . . . NP_001 MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPH 10 20 30 40 50 70 80 90 100 110 120 pF1KB8 EASEEDLLVVHTRRYLNELKWSFAVATITEIPPVIFLPNFLVQRKVLRPL----RTQTGG .:. :.. :. .:.. :. :. ...: . : . :. : . .::: NP_001 KATAEEMTKYHSDEYIKFLR-SIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGG 60 70 80 90 100 110 130 140 150 160 170 pF1KB8 TIMAGKLAVER---GWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATI .. :: . ..: :.: .::.:: ......::: ::.::: .: .. .:. NP_001 SV-AGAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAI---LELLKYHQRVLY 120 130 140 150 160 170 180 190 200 210 220 pF1KB8 IDLDAHQGNGHERDFMDDKRVYIMDVYNR-HIYPG-----DRFAKQAIRRKVELEW--GT ::.: :.:.: :. :. ::. .. .. . .:: : : .. :.. : NP_001 IDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGI 180 190 200 210 220 230 230 240 250 260 270 280 pF1KB8 EDDEYLDKVERNIKKSLQEHLPDVVVYNAGTDILEGDRLGGLSISPAGIVKRDELVFRMV .:. : . . :.: .. . :..:: . :.: : ::::: .... : .: :.: NP_001 DDESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVV---- 240 250 260 270 280 290 300 310 320 330 340 pF1KB8 RGRRVPILMVTSGGYQKRTARIIADSILNLFGLGLIGPESPSVSAQNSDTPLLPPAVP . .:.::. .::: : NP_001 KTFNLPLLMLGGGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPS 290 300 310 320 330 340 347 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 12:00:55 2016 done: Fri Nov 4 12:00:55 2016 Total Scan time: 6.090 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]