FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8360, 168 aa 1>>>pF1KB8360 168 - 168 aa - 168 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.2276+/-0.000295; mu= 14.0603+/- 0.019 mean_var=81.2056+/-15.755, 0's: 0 Z-trim(118.7): 43 B-trim: 0 in 0/51 Lambda= 0.142325 statistics sampled from 31789 (31833) to 31789 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.74), E-opt: 0.2 (0.373), width: 16 Scan time: 4.500 The best scores are: opt bits E(85289) NP_002816 (OMIM: 162095) pleiotrophin isoform 1 pr ( 168) 1167 248.3 4.4e-66 NP_001308315 (OMIM: 162095) pleiotrophin isoform 1 ( 168) 1167 248.3 4.4e-66 NP_001308316 (OMIM: 162095) pleiotrophin isoform 2 ( 167) 1150 244.8 4.9e-65 XP_016867962 (OMIM: 162095) PREDICTED: pleiotrophi ( 167) 1150 244.8 4.9e-65 NP_001257480 (OMIM: 162096) midkine isoform a prec ( 143) 509 113.1 1.8e-25 NP_001012334 (OMIM: 162096) midkine isoform a prec ( 143) 509 113.1 1.8e-25 XP_016873253 (OMIM: 162096) PREDICTED: midkine iso ( 143) 509 113.1 1.8e-25 NP_002382 (OMIM: 162096) midkine isoform a precurs ( 143) 509 113.1 1.8e-25 NP_001012333 (OMIM: 162096) midkine isoform a prec ( 143) 509 113.1 1.8e-25 XP_011518418 (OMIM: 162096) PREDICTED: midkine iso ( 143) 509 113.1 1.8e-25 NP_001257479 (OMIM: 162096) midkine isoform a prec ( 143) 509 113.1 1.8e-25 NP_001257481 (OMIM: 162096) midkine isoform b prec ( 87) 241 57.9 4.7e-09 >>NP_002816 (OMIM: 162095) pleiotrophin isoform 1 precur (168 aa) initn: 1167 init1: 1167 opt: 1167 Z-score: 1307.4 bits: 248.3 E(85289): 4.4e-66 Smith-Waterman score: 1167; 100.0% identity (100.0% similar) in 168 aa overlap (1-168:1-168) 10 20 30 40 50 60 pF1KB8 MQAQQYQQQRRKFAAAFLAFIFILAAVDTAEAGKKEKPEKKVKKSDCGEWQWSVCVPTSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 MQAQQYQQQRRKFAAAFLAFIFILAAVDTAEAGKKEKPEKKVKKSDCGEWQWSVCVPTSG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 DCGLGTREGTRTGAECKQTMKTQRCKIPCNWKKQFGAECKYQFQAWGECDLNTALKTRTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 DCGLGTREGTRTGAECKQTMKTQRCKIPCNWKKQFGAECKYQFQAWGECDLNTALKTRTG 70 80 90 100 110 120 130 140 150 160 pF1KB8 SLKRALHNAECQKTVTISKPCGKLTKPKPQAESKKKKKEGKKQEKMLD :::::::::::::::::::::::::::::::::::::::::::::::: NP_002 SLKRALHNAECQKTVTISKPCGKLTKPKPQAESKKKKKEGKKQEKMLD 130 140 150 160 >>NP_001308315 (OMIM: 162095) pleiotrophin isoform 1 pre (168 aa) initn: 1167 init1: 1167 opt: 1167 Z-score: 1307.4 bits: 248.3 E(85289): 4.4e-66 Smith-Waterman score: 1167; 100.0% identity (100.0% similar) in 168 aa overlap (1-168:1-168) 10 20 30 40 50 60 pF1KB8 MQAQQYQQQRRKFAAAFLAFIFILAAVDTAEAGKKEKPEKKVKKSDCGEWQWSVCVPTSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MQAQQYQQQRRKFAAAFLAFIFILAAVDTAEAGKKEKPEKKVKKSDCGEWQWSVCVPTSG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 DCGLGTREGTRTGAECKQTMKTQRCKIPCNWKKQFGAECKYQFQAWGECDLNTALKTRTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DCGLGTREGTRTGAECKQTMKTQRCKIPCNWKKQFGAECKYQFQAWGECDLNTALKTRTG 70 80 90 100 110 120 130 140 150 160 pF1KB8 SLKRALHNAECQKTVTISKPCGKLTKPKPQAESKKKKKEGKKQEKMLD :::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SLKRALHNAECQKTVTISKPCGKLTKPKPQAESKKKKKEGKKQEKMLD 130 140 150 160 >>NP_001308316 (OMIM: 162095) pleiotrophin isoform 2 pre (167 aa) initn: 1130 init1: 1079 opt: 1150 Z-score: 1288.6 bits: 244.8 E(85289): 4.9e-65 Smith-Waterman score: 1150; 99.4% identity (99.4% similar) in 168 aa overlap (1-168:1-167) 10 20 30 40 50 60 pF1KB8 MQAQQYQQQRRKFAAAFLAFIFILAAVDTAEAGKKEKPEKKVKKSDCGEWQWSVCVPTSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MQAQQYQQQRRKFAAAFLAFIFILAAVDTAEAGKKEKPEKKVKKSDCGEWQWSVCVPTSG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 DCGLGTREGTRTGAECKQTMKTQRCKIPCNWKKQFGAECKYQFQAWGECDLNTALKTRTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DCGLGTREGTRTGAECKQTMKTQRCKIPCNWKKQFGAECKYQFQAWGECDLNTALKTRTG 70 80 90 100 110 120 130 140 150 160 pF1KB8 SLKRALHNAECQKTVTISKPCGKLTKPKPQAESKKKKKEGKKQEKMLD :::::::::::::::::::::::::::::: ::::::::::::::::: NP_001 SLKRALHNAECQKTVTISKPCGKLTKPKPQ-ESKKKKKEGKKQEKMLD 130 140 150 160 >>XP_016867962 (OMIM: 162095) PREDICTED: pleiotrophin is (167 aa) initn: 1130 init1: 1079 opt: 1150 Z-score: 1288.6 bits: 244.8 E(85289): 4.9e-65 Smith-Waterman score: 1150; 99.4% identity (99.4% similar) in 168 aa overlap (1-168:1-167) 10 20 30 40 50 60 pF1KB8 MQAQQYQQQRRKFAAAFLAFIFILAAVDTAEAGKKEKPEKKVKKSDCGEWQWSVCVPTSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MQAQQYQQQRRKFAAAFLAFIFILAAVDTAEAGKKEKPEKKVKKSDCGEWQWSVCVPTSG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 DCGLGTREGTRTGAECKQTMKTQRCKIPCNWKKQFGAECKYQFQAWGECDLNTALKTRTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DCGLGTREGTRTGAECKQTMKTQRCKIPCNWKKQFGAECKYQFQAWGECDLNTALKTRTG 70 80 90 100 110 120 130 140 150 160 pF1KB8 SLKRALHNAECQKTVTISKPCGKLTKPKPQAESKKKKKEGKKQEKMLD :::::::::::::::::::::::::::::: ::::::::::::::::: XP_016 SLKRALHNAECQKTVTISKPCGKLTKPKPQ-ESKKKKKEGKKQEKMLD 130 140 150 160 >>NP_001257480 (OMIM: 162096) midkine isoform a precurso (143 aa) initn: 538 init1: 333 opt: 509 Z-score: 578.1 bits: 113.1 E(85289): 1.8e-25 Smith-Waterman score: 509; 48.4% identity (72.5% similar) in 153 aa overlap (9-161:2-142) 10 20 30 40 50 60 pF1KB8 MQAQQYQQQRRKFAAAFLAFIFILAAVDTAEAGKKEKPEKKVKKSDCGEWQWSVCVPTSG :.: : .: .. : :. .: : ::.: .: :.:.:: :. :.:.: NP_001 MQHRGF---LLLTLLALLALTSAVAKKKDKVKKGGPGSECAEWAWGPCTPSSK 10 20 30 40 50 70 80 90 100 110 120 pF1KB8 DCGLGTREGTRTGAECKQTMKTQRCKIPCNWKKQFGAECKYQFQAWGECDLNTALKTRTG :::.: :::: :: ::.. ::..::::::.:::.:::.:. :: :: .:. :.: : NP_001 DCGVGFREGT-CGA---QTQRI-RCRVPCNWKKEFGADCKYKFENWGACDGGTGTKVRQG 60 70 80 90 100 130 140 150 160 pF1KB8 SLKRALHNAECQKTVTISKPCGKLTKPKPQAESKKKKKEGKKQEKMLD .::.: .::.::.:. ..::: :: .:..: :: .:: NP_001 TLKKARYNAQCQETIRVTKPC----TPKTKAKAKAKKGKGKD 110 120 130 140 >>NP_001012334 (OMIM: 162096) midkine isoform a precurso (143 aa) initn: 538 init1: 333 opt: 509 Z-score: 578.1 bits: 113.1 E(85289): 1.8e-25 Smith-Waterman score: 509; 48.4% identity (72.5% similar) in 153 aa overlap (9-161:2-142) 10 20 30 40 50 60 pF1KB8 MQAQQYQQQRRKFAAAFLAFIFILAAVDTAEAGKKEKPEKKVKKSDCGEWQWSVCVPTSG :.: : .: .. : :. .: : ::.: .: :.:.:: :. :.:.: NP_001 MQHRGF---LLLTLLALLALTSAVAKKKDKVKKGGPGSECAEWAWGPCTPSSK 10 20 30 40 50 70 80 90 100 110 120 pF1KB8 DCGLGTREGTRTGAECKQTMKTQRCKIPCNWKKQFGAECKYQFQAWGECDLNTALKTRTG :::.: :::: :: ::.. ::..::::::.:::.:::.:. :: :: .:. :.: : NP_001 DCGVGFREGT-CGA---QTQRI-RCRVPCNWKKEFGADCKYKFENWGACDGGTGTKVRQG 60 70 80 90 100 130 140 150 160 pF1KB8 SLKRALHNAECQKTVTISKPCGKLTKPKPQAESKKKKKEGKKQEKMLD .::.: .::.::.:. ..::: :: .:..: :: .:: NP_001 TLKKARYNAQCQETIRVTKPC----TPKTKAKAKAKKGKGKD 110 120 130 140 >>XP_016873253 (OMIM: 162096) PREDICTED: midkine isoform (143 aa) initn: 538 init1: 333 opt: 509 Z-score: 578.1 bits: 113.1 E(85289): 1.8e-25 Smith-Waterman score: 509; 48.4% identity (72.5% similar) in 153 aa overlap (9-161:2-142) 10 20 30 40 50 60 pF1KB8 MQAQQYQQQRRKFAAAFLAFIFILAAVDTAEAGKKEKPEKKVKKSDCGEWQWSVCVPTSG :.: : .: .. : :. .: : ::.: .: :.:.:: :. :.:.: XP_016 MQHRGF---LLLTLLALLALTSAVAKKKDKVKKGGPGSECAEWAWGPCTPSSK 10 20 30 40 50 70 80 90 100 110 120 pF1KB8 DCGLGTREGTRTGAECKQTMKTQRCKIPCNWKKQFGAECKYQFQAWGECDLNTALKTRTG :::.: :::: :: ::.. ::..::::::.:::.:::.:. :: :: .:. :.: : XP_016 DCGVGFREGT-CGA---QTQRI-RCRVPCNWKKEFGADCKYKFENWGACDGGTGTKVRQG 60 70 80 90 100 130 140 150 160 pF1KB8 SLKRALHNAECQKTVTISKPCGKLTKPKPQAESKKKKKEGKKQEKMLD .::.: .::.::.:. ..::: :: .:..: :: .:: XP_016 TLKKARYNAQCQETIRVTKPC----TPKTKAKAKAKKGKGKD 110 120 130 140 >>NP_002382 (OMIM: 162096) midkine isoform a precursor [ (143 aa) initn: 538 init1: 333 opt: 509 Z-score: 578.1 bits: 113.1 E(85289): 1.8e-25 Smith-Waterman score: 509; 48.4% identity (72.5% similar) in 153 aa overlap (9-161:2-142) 10 20 30 40 50 60 pF1KB8 MQAQQYQQQRRKFAAAFLAFIFILAAVDTAEAGKKEKPEKKVKKSDCGEWQWSVCVPTSG :.: : .: .. : :. .: : ::.: .: :.:.:: :. :.:.: NP_002 MQHRGF---LLLTLLALLALTSAVAKKKDKVKKGGPGSECAEWAWGPCTPSSK 10 20 30 40 50 70 80 90 100 110 120 pF1KB8 DCGLGTREGTRTGAECKQTMKTQRCKIPCNWKKQFGAECKYQFQAWGECDLNTALKTRTG :::.: :::: :: ::.. ::..::::::.:::.:::.:. :: :: .:. :.: : NP_002 DCGVGFREGT-CGA---QTQRI-RCRVPCNWKKEFGADCKYKFENWGACDGGTGTKVRQG 60 70 80 90 100 130 140 150 160 pF1KB8 SLKRALHNAECQKTVTISKPCGKLTKPKPQAESKKKKKEGKKQEKMLD .::.: .::.::.:. ..::: :: .:..: :: .:: NP_002 TLKKARYNAQCQETIRVTKPC----TPKTKAKAKAKKGKGKD 110 120 130 140 >>NP_001012333 (OMIM: 162096) midkine isoform a precurso (143 aa) initn: 538 init1: 333 opt: 509 Z-score: 578.1 bits: 113.1 E(85289): 1.8e-25 Smith-Waterman score: 509; 48.4% identity (72.5% similar) in 153 aa overlap (9-161:2-142) 10 20 30 40 50 60 pF1KB8 MQAQQYQQQRRKFAAAFLAFIFILAAVDTAEAGKKEKPEKKVKKSDCGEWQWSVCVPTSG :.: : .: .. : :. .: : ::.: .: :.:.:: :. :.:.: NP_001 MQHRGF---LLLTLLALLALTSAVAKKKDKVKKGGPGSECAEWAWGPCTPSSK 10 20 30 40 50 70 80 90 100 110 120 pF1KB8 DCGLGTREGTRTGAECKQTMKTQRCKIPCNWKKQFGAECKYQFQAWGECDLNTALKTRTG :::.: :::: :: ::.. ::..::::::.:::.:::.:. :: :: .:. :.: : NP_001 DCGVGFREGT-CGA---QTQRI-RCRVPCNWKKEFGADCKYKFENWGACDGGTGTKVRQG 60 70 80 90 100 130 140 150 160 pF1KB8 SLKRALHNAECQKTVTISKPCGKLTKPKPQAESKKKKKEGKKQEKMLD .::.: .::.::.:. ..::: :: .:..: :: .:: NP_001 TLKKARYNAQCQETIRVTKPC----TPKTKAKAKAKKGKGKD 110 120 130 140 >>XP_011518418 (OMIM: 162096) PREDICTED: midkine isoform (143 aa) initn: 538 init1: 333 opt: 509 Z-score: 578.1 bits: 113.1 E(85289): 1.8e-25 Smith-Waterman score: 509; 48.4% identity (72.5% similar) in 153 aa overlap (9-161:2-142) 10 20 30 40 50 60 pF1KB8 MQAQQYQQQRRKFAAAFLAFIFILAAVDTAEAGKKEKPEKKVKKSDCGEWQWSVCVPTSG :.: : .: .. : :. .: : ::.: .: :.:.:: :. :.:.: XP_011 MQHRGF---LLLTLLALLALTSAVAKKKDKVKKGGPGSECAEWAWGPCTPSSK 10 20 30 40 50 70 80 90 100 110 120 pF1KB8 DCGLGTREGTRTGAECKQTMKTQRCKIPCNWKKQFGAECKYQFQAWGECDLNTALKTRTG :::.: :::: :: ::.. ::..::::::.:::.:::.:. :: :: .:. :.: : XP_011 DCGVGFREGT-CGA---QTQRI-RCRVPCNWKKEFGADCKYKFENWGACDGGTGTKVRQG 60 70 80 90 100 130 140 150 160 pF1KB8 SLKRALHNAECQKTVTISKPCGKLTKPKPQAESKKKKKEGKKQEKMLD .::.: .::.::.:. ..::: :: .:..: :: .:: XP_011 TLKKARYNAQCQETIRVTKPC----TPKTKAKAKAKKGKGKD 110 120 130 140 168 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 12:06:44 2016 done: Fri Nov 4 12:06:45 2016 Total Scan time: 4.500 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]